SIMILAR PATTERNS OF AMINO ACIDS FOR 1YVP_B_ACTB2002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fb5 ORNITHINE
TRANSCARBAMOYLASE

(Ovis aries) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 TYR A 284
ALA A 217
THR A 247
ASN A 248
 None
 1.19A 1yvpB-1fb5A:
undetectable		 1yvpB-1fb5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		4 TYR A 467
SER A 436
THR A 447
ASN A 451
 None
 1.10A 1yvpB-1gz7A:
undetectable		 1yvpB-1gz7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		4 TYR A 256
SER A 250
ALA A 251
SER A 252
 U  D 913 ( 4.0A)
A  D 914 ( 3.5A)
G  D 915 ( 2.9A)
A  D 914 ( 4.0A)
 1.00A 1yvpB-1j2bA:
undetectable		 1yvpB-1j2bA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE
AMINE DEHYDROGENASE

(Pseudomonas
putida;
Pseudomonas
putida) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII)
no annotation 		4 TYR A 135
SER B  96
THR B 109
ASN B 111
 None
 1.03A 1yvpB-1jmzA:
undetectable		 1yvpB-1jmzA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE

(Staphylococcus
aureus) 		PF02388
(FemAB) 		4 TYR A 327
SER A 314
ALA A 315
THR A 332
 None
 0.85A 1yvpB-1lrzA:
2.3		 1yvpB-1lrzA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbx ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLP A

(Escherichia
coli) 		PF02861
(Clp_N) 		4 ALA A  40
SER A  39
THR A 104
ASN A   3
 None
 0.98A 1yvpB-1mbxA:
undetectable		 1yvpB-1mbxA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mcw IMMUNOGLOBULIN WEIR
(LIGHT CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER W  74
ALA W  73
SER W  67
THR W  19
 None
 1.21A 1yvpB-1mcwW:
undetectable		 1yvpB-1mcwW:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 TYR C 420
SER C  16
ALA C  15
THR C  19
 None
 1.13A 1yvpB-1n8yC:
undetectable		 1yvpB-1n8yC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		4 ALA A 135
SER A 136
THR A 204
ASN A 202
 NAI  A 301 (-3.7A)
None
NAI  A 301 (-4.4A)
None
 1.07A 1yvpB-1o9bA:
undetectable		 1yvpB-1o9bA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oul STRINGENT STARVATION
PROTEIN B HOMOLOG

(Haemophilus
influenzae) 		PF04386
(SspB) 		4 SER A  55
ALA A  56
SER A  57
THR A  26
 None
 0.75A 1yvpB-1oulA:
undetectable		 1yvpB-1oulA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0p COMPLEMENT FACTOR B

(Homo sapiens) 		PF00092
(VWA) 		4 SER A 253
SER A 255
THR A 328
ASN A 368
 MN  A 500 (-2.1A)
MN  A 500 (-2.1A)
MN  A 500 (-2.8A)
None
 0.26A 1yvpB-1q0pA:
7.9		 1yvpB-1q0pA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh7 RESISTIN-LIKE BETA

(Mus musculus) 		PF06954
(Resistin) 		4 SER A  75
ALA A  76
SER A  28
THR A  30
 None
 1.17A 1yvpB-1rh7A:
undetectable		 1yvpB-1rh7A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtk COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 SER A 253
SER A 255
THR A 328
ASN A 368
 MG  A 749 (-2.3A)
MG  A 749 (-2.4A)
MG  A 749 (-2.9A)
None
 0.39A 1yvpB-1rtkA:
12.0		 1yvpB-1rtkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sml PROTEIN
(PENICILLINASE)

(Stenotrophomonas
maltophilia) 		PF00753
(Lactamase_B) 		4 TYR A 233
SER A 229
ALA A 243
THR A 223
 None
 1.18A 1yvpB-1smlA:
undetectable		 1yvpB-1smlA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		4 TYR A 481
SER A 449
THR A 461
ASN A 465
 None
 1.14A 1yvpB-1thgA:
undetectable		 1yvpB-1thgA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twb STRINGENT STARVATION
PROTEIN B HOMOLOG

(Haemophilus
influenzae) 		PF04386
(SspB) 		4 SER A  55
ALA A  56
SER A  57
THR A  26
 None
 0.79A 1yvpB-1twbA:
undetectable		 1yvpB-1twbA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8s GLYCINE CLEAVAGE
SYSTEM
TRANSCRIPTIONAL
REPRESSOR, PUTATIVE

(Vibrio cholerae) 		PF13740
(ACT_6) 		4 SER A 146
ALA A 122
THR A  93
ASN A 180
 None
 1.00A 1yvpB-1u8sA:
undetectable		 1yvpB-1u8sA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		4 ALA A 657
SER A 400
THR A 660
ASN A 661
 None
 1.00A 1yvpB-1w7cA:
undetectable		 1yvpB-1w7cA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 TYR A 269
ALA A 300
SER A 297
ASN A 238
 NAD  A 600 (-3.8A)
None
None
NAD  A 600 (-3.1A)
 1.10A 1yvpB-1x87A:
undetectable		 1yvpB-1x87A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Helicobacter
pylori) 		PF02540
(NAD_synthase) 		4 SER A 102
ALA A 101
THR A 104
ASN A 108
 None
None
DND  A 301 (-4.0A)
DND  A 301 (-3.2A)
 1.04A 1yvpB-1xngA:
undetectable		 1yvpB-1xngA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C) 		4 SER A 102
ALA A 101
SER A 187
THR A 105
 None
 1.14A 1yvpB-1yjkA:
undetectable		 1yvpB-1yjkA:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		6 TYR A  47
SER A 378
ALA A 379
SER A 380
THR A 445
ASN A 473
 None
MG  A1001 ( 2.2A)
ACT  A2001 (-4.0A)
MG  A1001 ( 2.1A)
MG  A1001 ( 2.9A)
ACT  A2001 (-3.1A)
 0.27A 1yvpB-1yvpA:
58.4		 1yvpB-1yvpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzu FIBER PROTEIN 2

(Human
mastadenovirus
F) 		PF00541
(Adeno_knob) 		4 SER A 367
ALA A 283
THR A 348
ASN A 338
 None
 1.14A 1yvpB-2bzuA:
undetectable		 1yvpB-2bzuA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgq OUTER MEMBRANE PORIN
PROTEIN 32

(Delftia
acidovorans) 		PF13609
(Porin_4) 		4 SER X 184
ALA X 185
SER X 186
ASN X 149
 None
 0.87A 1yvpB-2fgqX:
undetectable		 1yvpB-2fgqX:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipf (3(17)ALPHA-HYDROXYS
TEROID
DEHYDROGENASE)

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 TYR A  81
ALA A  52
SER A  51
THR A  57
 None
 1.20A 1yvpB-2ipfA:
undetectable		 1yvpB-2ipfA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 SER A  85
ALA A  86
SER A 127
THR A  23
 None
 1.21A 1yvpB-2ldxA:
undetectable		 1yvpB-2ldxA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 SER A 242
SER A 244
THR A 317
ASN A 360
 MG  A 901 (-1.9A)
MG  A 901 (-2.2A)
MG  A 901 (-2.6A)
None
 0.22A 1yvpB-2odpA:
11.7		 1yvpB-2odpA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		4 SER A1113
ALA A1200
SER A1199
THR A1156
 None
 0.89A 1yvpB-2oxfA:
undetectable		 1yvpB-2oxfA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		4 SER A1113
SER A1199
THR A1156
ASN A1194
 None
 1.10A 1yvpB-2oxfA:
undetectable		 1yvpB-2oxfA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6p GLYCOSYL TRANSFERASE

(Streptomyces
fradiae) 		PF06722
(DUF1205) 		4 SER A  95
ALA A  92
THR A  54
ASN A  36
 None
 1.14A 1yvpB-2p6pA:
3.7		 1yvpB-2p6pA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN

(Escherichia
coli) 		PF03349
(Toluene_X) 		4 SER A  97
SER A  31
THR A  99
ASN A 101
 None
 1.03A 1yvpB-2r8aA:
undetectable		 1yvpB-2r8aA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT FACTOR B

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA) 		4 SER F 253
SER F 255
THR F 328
ASN F 368
 MG  F1742 (-2.0A)
MG  F1742 (-2.0A)
MG  F1742 (-2.1A)
None
 0.53A 1yvpB-2xwbF:
9.3		 1yvpB-2xwbF:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		4 SER A 190
ALA A 191
THR A 199
ASN A 278
 None
 1.03A 1yvpB-2zwvA:
2.5		 1yvpB-2zwvA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvm ENTEROTOXIN TYPE C-3

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 TYR A  77
SER A 153
THR A 222
ASN A 220
 None
 1.17A 1yvpB-3bvmA:
undetectable		 1yvpB-3bvmA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2

(Actinoplanes
teichomyceticus) 		PF02585
(PIG-L) 		4 TYR A 229
SER A  14
ALA A  20
THR A  42
 None
 0.89A 1yvpB-3dffA:
2.0		 1yvpB-3dffA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21

(Actinoplanes
teichomyceticus) 		PF02585
(PIG-L) 		4 TYR A 226
SER A  14
ALA A  20
THR A  42
 None
 0.85A 1yvpB-3dfiA:
undetectable		 1yvpB-3dfiA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		4 SER A 145
ALA A 146
SER A 147
THR A 129
 None
GOL  A 500 ( 4.2A)
GOL  A 500 (-3.5A)
None
 1.03A 1yvpB-3eafA:
4.7		 1yvpB-3eafA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evn OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
agalactiae) 		PF01408
(GFO_IDH_MocA) 		4 TYR A 316
SER A 213
ALA A 202
THR A 175
 None
 1.18A 1yvpB-3evnA:
undetectable		 1yvpB-3evnA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		4 TYR A  75
SER A 121
ALA A 100
SER A 101
 None
 1.10A 1yvpB-3jroA:
undetectable		 1yvpB-3jroA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 TYR A 456
ALA A 511
SER A 510
ASN A 247
 None
 1.20A 1yvpB-3kjrA:
undetectable		 1yvpB-3kjrA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lso PUTATIVE MEMBRANE
ANCHORED PROTEIN

(Corynebacterium
diphtheriae) 		PF16640
(Big_3_5) 		4 SER B 345
ALA B 346
SER B 347
ASN B 378
 None
 1.05A 1yvpB-3lsoB:
undetectable		 1yvpB-3lsoB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwd 6-PHOSPHOGLUCONOLACT
ONASE

(Chromohalobacter
salexigens) 		PF01182
(Glucosamine_iso) 		4 SER A 174
ALA A 175
SER A 176
THR A 154
 None
 1.04A 1yvpB-3lwdA:
undetectable		 1yvpB-3lwdA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 SER A 313
ALA A 315
SER A 316
ASN A 286
 None
 1.16A 1yvpB-3p5pA:
2.3		 1yvpB-3p5pA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qye TBC1 DOMAIN FAMILY
MEMBER 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 TYR A 874
SER A 881
ALA A 879
THR A 842
 None
 1.09A 1yvpB-3qyeA:
undetectable		 1yvpB-3qyeA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rag UNCHARACTERIZED
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00092
(VWA) 		4 SER A 141
ALA A 142
SER A 143
ASN A  19
 NA  A 240 (-2.6A)
None
NA  A 240 (-2.5A)
None
 0.66A 1yvpB-3ragA:
4.1		 1yvpB-3ragA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rag UNCHARACTERIZED
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00092
(VWA) 		4 SER A 141
ALA A 142
THR A 209
ASN A  19
 NA  A 240 (-2.6A)
None
NA  A 240 ( 4.6A)
None
 0.55A 1yvpB-3ragA:
4.1		 1yvpB-3ragA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rap PROTEIN (G PROTEIN
RAP2A)

(Homo sapiens) 		PF00071
(Ras) 		4 TYR R   4
SER R  49
SER R  51
ASN R 165
 None
 1.15A 1yvpB-3rapR:
undetectable		 1yvpB-3rapR:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 TYR A 349
SER A 522
ALA A 157
ASN A 409
 None
 1.14A 1yvpB-3rx8A:
undetectable		 1yvpB-3rx8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum) 		PF00696
(AA_kinase)
PF01842
(ACT) 		4 SER A  11
ALA A  14
SER A  12
ASN A 266
 None
 1.21A 1yvpB-3tviA:
2.8		 1yvpB-3tviA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 SER A  23
ALA A  22
THR A  25
ASN A  29
 None
 1.05A 1yvpB-3uk1A:
3.1		 1yvpB-3uk1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E

(Homo sapiens) 		PF00067
(p450) 		4 SER A 358
ALA A 359
SER A 360
ASN A 289
 None
None
0GV  A 602 ( 3.1A)
HEM  A 601 (-4.1A)
 0.85A 1yvpB-3v8dA:
undetectable		 1yvpB-3v8dA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 TYR A 360
SER A 394
THR A 401
ASN A 354
 None
 1.17A 1yvpB-3wa1A:
undetectable		 1yvpB-3wa1A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		4 TYR A 595
ALA A 626
SER A 586
ASN A 580
 None
 1.17A 1yvpB-3wajA:
2.2		 1yvpB-3wajA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		4 ALA A 548
SER A 547
THR A 515
ASN A 506
 None
 0.98A 1yvpB-3wfzA:
undetectable		 1yvpB-3wfzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjj TRANSCRIPTION FACTOR
TAU SUBUNIT SFC1
TRANSCRIPTION FACTOR
TAU SUBUNIT SFC7

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF09734
(Tau95)
PF10419
(TFIIIC_sub6) 		4 TYR A  11
SER A   7
SER A  91
ASN B  72
 None
 1.16A 1yvpB-4bjjA:
undetectable		 1yvpB-4bjjA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 SER A  88
ALA A  89
SER A  61
THR A 185
 NO3  A1305 ( 4.6A)
None
NO3  A1305 (-2.3A)
NO3  A1305 ( 4.8A)
 1.16A 1yvpB-4bkmA:
2.2		 1yvpB-4bkmA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		4 TYR A  48
SER A  55
ALA A  53
ASN A 342
 None
 1.13A 1yvpB-4c1tA:
undetectable		 1yvpB-4c1tA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE

(Chloroflexus
aurantiacus) 		PF01575
(MaoC_dehydratas) 		4 TYR A 143
SER A 110
SER A 130
THR A  77
 None
 1.11A 1yvpB-4e3eA:
undetectable		 1yvpB-4e3eA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuk METHIONINE
AMINOPEPTIDASE

(Trypanosoma
brucei) 		PF00557
(Peptidase_M24) 		4 TYR A 178
SER A 100
ALA A  99
SER A  98
 None
 0.96A 1yvpB-4fukA:
undetectable		 1yvpB-4fukA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE

(Thermothelomyces
thermophila) 		no annotation 4 SER A 112
ALA A 113
SER A  97
THR A  99
 None
None
None
EDO  A 502 (-4.7A)
 1.21A 1yvpB-4g4iA:
2.4		 1yvpB-4g4iA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyq PHOSPHOLIPASE A1

(Streptomyces
albidoflavus) 		PF13472
(Lipase_GDSL_2) 		4 ALA A  46
SER A  47
THR A  73
ASN A  70
 None
 0.99A 1yvpB-4hyqA:
undetectable		 1yvpB-4hyqA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4s NUCLEOCAPSID PROTEIN

(SFTS
phlebovirus) 		PF05733
(Tenui_N) 		4 SER A 189
ALA A 188
THR A 191
ASN A 195
 None
 1.07A 1yvpB-4j4sA:
undetectable		 1yvpB-4j4sA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwo PHOSPHATE BINDING
PROTEIN

(Planctopirus
limnophila) 		PF12727
(PBP_like) 		4 SER A  65
ALA A 112
SER A 113
THR A  67
 SO4  A 401 (-2.9A)
None
SO4  A 401 (-2.2A)
SO4  A 401 ( 4.9A)
 1.15A 1yvpB-4jwoA:
undetectable		 1yvpB-4jwoA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nap EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Desulfovibrio
alaskensis) 		PF03480
(DctP) 		4 SER A 212
ALA A 151
SER A 150
THR A 211
 DTR  A 401 (-3.3A)
None
DTR  A 401 ( 4.6A)
DTR  A 401 (-3.0A)
 1.21A 1yvpB-4napA:
undetectable		 1yvpB-4napA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		4 TYR A 250
SER A 258
THR A 260
ASN A 261
 None
 0.80A 1yvpB-4nkyA:
undetectable		 1yvpB-4nkyA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Shewanella
benthica) 		PF00701
(DHDPS) 		4 SER A 125
ALA A 123
THR A  89
ASN A  77
 None
 1.16A 1yvpB-4pfmA:
undetectable		 1yvpB-4pfmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8k ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		4 ALA A 231
SER A 346
THR A 235
ASN A 322
 None
 1.19A 1yvpB-4q8kA:
undetectable		 1yvpB-4q8kA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8l ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		4 ALA A  64
SER A 179
THR A  68
ASN A 155
 None
 1.13A 1yvpB-4q8lA:
undetectable		 1yvpB-4q8lA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C) 		4 SER A 264
ALA A 263
THR A 265
ASN A 267
 None
 0.90A 1yvpB-4qi4A:
2.3		 1yvpB-4qi4A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi6 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		4 SER A 264
ALA A 263
THR A 265
ASN A 267
 None
 0.94A 1yvpB-4qi6A:
undetectable		 1yvpB-4qi6A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 4 TYR A 462
ALA A 450
SER A 451
ASN A 417
 None
 1.06A 1yvpB-4qnlA:
4.2		 1yvpB-4qnlA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 4 SER H 770
ALA H 765
SER H 777
ASN H 803
 None
 1.17A 1yvpB-4qslH:
3.6		 1yvpB-4qslH:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		4 SER A 110
ALA A 197
SER A 196
THR A 153
 None
 0.82A 1yvpB-4r2wA:
2.8		 1yvpB-4r2wA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuj GLYCOSIDE HYDROLASE
FAMILY 15, CELLULOSE
SIGNALING ASSOCIATED
PROTEIN ENVOY

(Trichoderma
reesei) 		PF13426
(PAS_9) 		4 TYR A 114
SER A  68
ALA A  69
SER A  70
 None
 0.92A 1yvpB-4wujA:
undetectable		 1yvpB-4wujA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybn FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN

(Mycolicibacterium
smegmatis) 		PF12900
(Pyridox_ox_2) 		4 SER A 105
ALA A 106
SER A  83
THR A  85
 None
 1.15A 1yvpB-4ybnA:
undetectable		 1yvpB-4ybnA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 SER A 305
ALA A 306
SER A 307
THR A 317
 None
 0.73A 1yvpB-4ymkA:
undetectable		 1yvpB-4ymkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 SER A 309
ALA A 310
SER A 311
THR A 321
 None
 0.70A 1yvpB-4zyoA:
undetectable		 1yvpB-4zyoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		4 SER A 441
ALA A 440
THR A 387
ASN A 384
 None
 1.12A 1yvpB-5b1qA:
undetectable		 1yvpB-5b1qA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnc HEME BINDING PROTEIN
MSMEG_6519

(Mycolicibacterium
smegmatis) 		PF10615
(DUF2470)
PF13883
(Pyrid_oxidase_2) 		4 ALA A  57
SER A  58
THR A  48
ASN A  82
 None
EPE  A 302 ( 4.8A)
None
None
 1.13A 1yvpB-5bncA:
undetectable		 1yvpB-5bncA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 TYR A 727
ALA A 572
SER A 573
ASN A 563
 None
NA  A 903 ( 4.0A)
None
None
 1.04A 1yvpB-5dmyA:
undetectable		 1yvpB-5dmyA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 TYR A 199
SER A 169
ALA A 347
SER A 346
 None
 1.06A 1yvpB-5e6kA:
undetectable		 1yvpB-5e6kA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Homo sapiens) 		PF00903
(Glyoxalase)
PF13669
(Glyoxalase_4) 		4 TYR A 160
SER A  72
SER A  59
THR A  23
 TYR  A 160 ( 1.3A)
SER  A  72 ( 0.0A)
SER  A  59 ( 0.0A)
THR  A  23 ( 0.8A)
 1.17A 1yvpB-5ec3A:
undetectable		 1yvpB-5ec3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 TYR B 360
SER B 394
THR B 401
ASN B 354
 None
 1.05A 1yvpB-5fozB:
undetectable		 1yvpB-5fozB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h05 AMYP

(marine
metagenome) 		PF00128
(Alpha-amylase) 		4 TYR A 217
ALA A  62
THR A 337
ASN A 290
 None
 1.17A 1yvpB-5h05A:
undetectable		 1yvpB-5h05A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE

(Streptomyces
toxytricini) 		PF04820
(Trp_halogenase) 		4 TYR A 394
SER A 356
ALA A 351
SER A 344
 None
 0.99A 1yvpB-5hy5A:
undetectable		 1yvpB-5hy5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8n EXODEOXYRIBONUCLEASE
III

(Methanosarcina
mazei) 		PF03372
(Exo_endo_phos) 		4 SER A 239
ALA A 238
SER A 237
ASN A   6
 None
 0.98A 1yvpB-5j8nA:
undetectable		 1yvpB-5j8nA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		4 SER A 112
ALA A 199
SER A 198
THR A 155
 None
 0.87A 1yvpB-5lhvA:
undetectable		 1yvpB-5lhvA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		4 SER A 112
SER A 198
THR A 155
ASN A 193
 None
 1.18A 1yvpB-5lhvA:
undetectable		 1yvpB-5lhvA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 SER A 422
ALA A 424
SER A 425
THR A 458
 None
 0.88A 1yvpB-5ltaA:
undetectable		 1yvpB-5ltaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		4 TYR A 390
SER A 352
ALA A 347
SER A 340
 None
 1.02A 1yvpB-5lv9A:
2.8		 1yvpB-5lv9A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtj TYROSINE-PROTEIN
KINASE YES
MONOBODY MB(YES_1)

(Mus musculus;
Homo sapiens) 		PF00017
(SH2)
PF00041
(fn3) 		4 TYR B  82
SER A 158
ALA A 164
THR A 160
 None
SO4  A 301 (-2.7A)
None
SO4  A 301 (-2.7A)
 1.14A 1yvpB-5mtjB:
undetectable		 1yvpB-5mtjB:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 TYR A 453
ALA A 508
SER A 509
THR A 482
 None
 1.06A 1yvpB-5nz7A:
undetectable		 1yvpB-5nz7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 4 TYR C 419
SER C  16
ALA C  15
THR C  19
 None
 1.10A 1yvpB-5o4gC:
undetectable		 1yvpB-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oei UNCHARACTERIZED
PROTEIN FAMILY
UPF0065:TAT PATHWAY
SIGNAL

(Rhodopseudomonas
palustris) 		no annotation 4 SER A 169
ALA A 170
SER A 173
ASN A 216
 OOG  A 401 (-3.0A)
OOG  A 401 ( 4.8A)
OOG  A 401 (-4.6A)
OOG  A 401 (-3.1A)
 1.10A 1yvpB-5oeiA:
undetectable		 1yvpB-5oeiA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubu PUTATIVE
ACETAMIDASE/FORMAMID
ASE

(Yersinia
enterocolitica) 		PF03069
(FmdA_AmdA) 		4 SER A 266
ALA A 267
THR A 317
ASN A 310
 None
 1.07A 1yvpB-5ubuA:
undetectable		 1yvpB-5ubuA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0x TIP41-LIKE PROTEIN

(Mus musculus) 		no annotation 4 TYR A 202
SER A 177
ALA A 205
SER A 178
 None
 1.16A 1yvpB-5w0xA:
undetectable		 1yvpB-5w0xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwq FUNGAL CHITINASE
FROM RHIZOMUCOR
MIEHEI (NATIVE
PROTEIN)

(Rhizomucor
miehei) 		no annotation 4 TYR A 389
SER A 323
ALA A 322
THR A 324
 None
 1.08A 1yvpB-5xwqA:
undetectable		 1yvpB-5xwqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3p AMY13K

([Eubacterium]
rectale) 		no annotation 4 SER A 362
SER A 364
THR A 182
ASN A 184
 None
FMT  A 422 (-3.2A)
None
None
 1.09A 1yvpB-6b3pA:
undetectable		 1yvpB-6b3pA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ged PRGB

(Enterococcus
faecalis) 		no annotation 4 SER A 383
SER A 385
THR A 404
ASN A 389
 None
 1.02A 1yvpB-6gedA:
undetectable		 1yvpB-6gedA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8pch CATHEPSIN H

(Sus scrofa) 		PF00112
(Peptidase_C1) 		4 TYR A 149
SER A 153
SER A 151
THR A 138
 None
 1.15A 1yvpB-8pchA:
undetectable		 1yvpB-8pchA:
16.85