SIMILAR PATTERNS OF AMINO ACIDS FOR 1YVP_A_ACTA2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR

(Escherichia
coli) 		PF12849
(PBP_like_2) 		4 TYR A 193
SER A 139
SER A 142
ASN A 177
 None
PO4  A 322 ( 2.6A)
None
PO4  A 322 ( 4.6A)
 1.31A 1yvpA-1a40A:
undetectable		 1yvpA-1a40A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00266
(Aminotran_5) 		4 TYR A 339
SER A 337
THR A 153
ASN A 151
 LLP  A 198 ( 3.5A)
None
LLP  A 198 ( 3.5A)
None
 1.40A 1yvpA-1bjnA:
undetectable		 1yvpA-1bjnA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		4 TYR A 339
SER A 337
THR A 153
ASN A 151
 None
None
PLP  A 363 (-3.3A)
None
 1.43A 1yvpA-1bt4A:
undetectable		 1yvpA-1bt4A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		4 SER A 160
SER A 159
THR A 290
ASN A 291
 None
 1.42A 1yvpA-1crlA:
undetectable		 1yvpA-1crlA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdp ATRIAL NATRIURETIC
PEPTIDE CLEARANCE
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 TYR A 271
SER A 256
THR A 276
ASN A 243
 None
 1.29A 1yvpA-1jdpA:
5.2		 1yvpA-1jdpA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE
AMINE DEHYDROGENASE

(Pseudomonas
putida;
Pseudomonas
putida) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII)
no annotation 		4 TYR A 135
SER B  96
THR B 109
ASN B 111
 None
 1.19A 1yvpA-1jmzA:
undetectable		 1yvpA-1jmzA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0p COMPLEMENT FACTOR B

(Homo sapiens) 		PF00092
(VWA) 		4 SER A 253
SER A 255
THR A 328
ASN A 368
 MN  A 500 (-2.1A)
MN  A 500 (-2.1A)
MN  A 500 (-2.8A)
None
 0.24A 1yvpA-1q0pA:
11.0		 1yvpA-1q0pA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtk COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 SER A 253
SER A 255
THR A 328
ASN A 368
 MG  A 749 (-2.3A)
MG  A 749 (-2.4A)
MG  A 749 (-2.9A)
None
 0.31A 1yvpA-1rtkA:
12.1		 1yvpA-1rtkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		4 TYR A 481
SER A 449
THR A 461
ASN A 465
 None
 1.25A 1yvpA-1thgA:
undetectable		 1yvpA-1thgA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 SER A 268
SER A 270
THR A 243
ASN A 291
 None
 1.41A 1yvpA-1vkoA:
2.6		 1yvpA-1vkoA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1u SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 5A

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 SER A 620
SER A 622
THR A 628
ASN A 642
 None
 1.44A 1yvpA-1y1uA:
4.1		 1yvpA-1y1uA:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		5 TYR A  47
SER A 378
SER A 380
THR A 445
ASN A 473
 None
MG  A1001 ( 2.2A)
MG  A1001 ( 2.1A)
MG  A1001 ( 2.9A)
ACT  A2001 (-3.1A)
 0.00A 1yvpA-1yvpA:
67.3		 1yvpA-1yvpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 TYR A 480
SER A 478
THR A 686
ASN A 689
 None
 1.20A 1yvpA-2np0A:
undetectable		 1yvpA-2np0A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 SER A 242
SER A 244
THR A 317
ASN A 360
 MG  A 901 (-1.9A)
MG  A 901 (-2.2A)
MG  A 901 (-2.6A)
None
 0.22A 1yvpA-2odpA:
11.7		 1yvpA-2odpA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		4 SER A1113
SER A1199
THR A1156
ASN A1194
 None
 1.20A 1yvpA-2oxfA:
undetectable		 1yvpA-2oxfA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN

(Escherichia
coli) 		PF03349
(Toluene_X) 		4 SER A  97
SER A  31
THR A  99
ASN A 101
 None
 1.07A 1yvpA-2r8aA:
undetectable		 1yvpA-2r8aA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d) 		4 TYR A 162
SER A 160
THR A 171
ASN A 142
 None
 1.44A 1yvpA-2rhqA:
undetectable		 1yvpA-2rhqA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ver AFIMBRIAL ADHESIN
AFA-III
ARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 5

(Escherichia
coli;
Homo sapiens) 		PF04619
(Adhesin_Dr)
PF07686
(V-set) 		4 TYR N  34
SER N  32
THR A  95
ASN A  74
 None
None
MTN  N1111 ( 4.7A)
None
 1.40A 1yvpA-2verN:
undetectable		 1yvpA-2verN:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhl BOTULINUM NEUROTOXIN
B HEAVY CHAIN

(Clostridium
botulinum) 		PF07952
(Toxin_trans) 		4 TYR B 496
SER B 494
THR B 702
ASN B 705
 None
 1.30A 1yvpA-2xhlB:
2.2		 1yvpA-2xhlB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT FACTOR B

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA) 		4 SER F 253
SER F 255
THR F 328
ASN F 368
 MG  F1742 (-2.0A)
MG  F1742 (-2.0A)
MG  F1742 (-2.1A)
None
 0.49A 1yvpA-2xwbF:
9.5		 1yvpA-2xwbF:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 TYR A 245
SER A 243
THR A 365
ASN A 375
 None
 1.36A 1yvpA-2yd0A:
undetectable		 1yvpA-2yd0A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG

(Escherichia
coli) 		PF05368
(NmrA) 		4 TYR A 140
SER A  73
THR A 102
ASN A 137
 NDP  A 400 (-3.8A)
NDP  A 400 (-3.4A)
None
None
 1.38A 1yvpA-2zcvA:
undetectable		 1yvpA-2zcvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anv D-SERINE DEHYDRATASE

(Gallus gallus) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 SER A 226
SER A 255
THR A 222
ASN A 242
 None
None
PLP  A 401 (-3.7A)
None
 1.36A 1yvpA-3anvA:
undetectable		 1yvpA-3anvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvm ENTEROTOXIN TYPE C-3

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 TYR A  77
SER A 153
THR A 222
ASN A 220
 None
 1.28A 1yvpA-3bvmA:
undetectable		 1yvpA-3bvmA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju7 PUTATIVE
PLP-DEPENDENT
AMINOTRANSFERASE

(Bacillus cereus) 		PF01041
(DegT_DnrJ_EryC1) 		4 SER A  84
SER A 321
THR A 339
ASN A 340
 None
 1.34A 1yvpA-3ju7A:
2.0		 1yvpA-3ju7A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5u PHOSPHOSERINE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00266
(Aminotran_5) 		4 TYR A 335
SER A 333
THR A 148
ASN A 146
 None
None
MES  A 362 (-3.9A)
None
 1.42A 1yvpA-3m5uA:
2.1		 1yvpA-3m5uA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myu HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
genitalium) 		PF06646
(Mycoplasma_p37) 		4 TYR A 176
SER A 216
SER A 218
ASN A  95
 VIB  A 500 (-3.8A)
None
None
VIB  A 500 ( 4.8A)
 1.07A 1yvpA-3myuA:
undetectable		 1yvpA-3myuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbo PHOSPHOSERINE
AMINOTRANSFERASE

(Yersinia pestis) 		PF00266
(Aminotran_5) 		4 TYR A 338
SER A 336
THR A 153
ASN A 151
 None
None
PLP  A 501 (-2.9A)
None
 1.44A 1yvpA-3qboA:
undetectable		 1yvpA-3qboA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		4 TYR A 213
SER A 155
SER A 158
ASN A 238
 None
 1.22A 1yvpA-3qfhA:
4.4		 1yvpA-3qfhA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm2 PHOSPHOSERINE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		4 TYR A 339
SER A 337
THR A 153
ASN A 151
 None
 1.37A 1yvpA-3qm2A:
3.6		 1yvpA-3qm2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 TYR A 360
SER A 394
THR A 401
ASN A 354
 None
 1.20A 1yvpA-3wa1A:
undetectable		 1yvpA-3wa1A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 SER A 578
SER A 523
THR A 580
ASN A 623
 None
 1.46A 1yvpA-3zz1A:
4.4		 1yvpA-3zz1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjj TRANSCRIPTION FACTOR
TAU SUBUNIT SFC1
TRANSCRIPTION FACTOR
TAU SUBUNIT SFC7

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF09734
(Tau95)
PF10419
(TFIIIC_sub6) 		4 TYR A  11
SER A   7
SER A  91
ASN B  72
 None
 1.19A 1yvpA-4bjjA:
undetectable		 1yvpA-4bjjA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3e MAOC DOMAIN PROTEIN
DEHYDRATASE

(Chloroflexus
aurantiacus) 		PF01575
(MaoC_dehydratas) 		4 TYR A 143
SER A 110
SER A 130
THR A  77
 None
 1.11A 1yvpA-4e3eA:
undetectable		 1yvpA-4e3eA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
NAD-BINDING

(Dyadobacter
fermentans) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 TYR A 115
SER A  94
SER A  92
ASN A 168
 None
 1.29A 1yvpA-4gbjA:
4.1		 1yvpA-4gbjA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 TYR A 227
SER A 193
SER A 196
THR A 189
 None
 1.49A 1yvpA-4gpgA:
undetectable		 1yvpA-4gpgA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqn SPOROZOITE SURFACE
PROTEIN 2

(Plasmodium
vivax) 		PF00090
(TSP_1)
PF00092
(VWA) 		4 SER A  52
SER A  54
THR A 127
ASN A 162
 MN  A 301 (-2.2A)
MN  A 301 (-2.1A)
MN  A 301 ( 2.7A)
CL  A 304 (-4.8A)
 0.90A 1yvpA-4hqnA:
11.4		 1yvpA-4hqnA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Kitasatospora
aureofaciens;
Influenza A
virus) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		4 SER A  35
SER A  38
THR A 189
ASN A 185
 None
 1.28A 1yvpA-4iq4A:
4.0		 1yvpA-4iq4A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF05431
(Toxin_10) 		4 TYR A   8
SER A 139
THR A 142
ASN A   5
 None
 1.45A 1yvpA-4jp0A:
undetectable		 1yvpA-4jp0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		4 TYR A 101
SER A  78
THR A  66
ASN A  93
 None
 1.47A 1yvpA-4krgA:
undetectable		 1yvpA-4krgA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		4 TYR A 250
SER A 258
THR A 260
ASN A 261
 None
 1.03A 1yvpA-4nkyA:
undetectable		 1yvpA-4nkyA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST

(Escherichia
coli) 		PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N) 		4 SER A 519
SER A 498
THR A 501
ASN A 436
 None
None
4NS  A 601 (-4.2A)
4NS  A 601 (-3.3A)
 1.40A 1yvpA-4p05A:
undetectable		 1yvpA-4p05A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		4 SER A 110
SER A 196
THR A 153
ASN A 191
 None
 1.31A 1yvpA-4r2wA:
2.8		 1yvpA-4r2wA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvi AMINOTRANSFERASE,
CLASS IV

(Brucella
abortus) 		PF01063
(Aminotran_4) 		4 SER A 210
SER A 267
THR A 207
ASN A 194
 None
 1.40A 1yvpA-4tviA:
undetectable		 1yvpA-4tviA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk1 PHOSPHOSERINE
AMINOTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		4 TYR A 338
SER A 336
THR A 153
ASN A 151
 LLP  A 197 ( 4.0A)
None
LLP  A 197 ( 3.0A)
None
 1.38A 1yvpA-4xk1A:
undetectable		 1yvpA-4xk1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 SER A 370
SER A 342
THR A 367
ASN A 295
 None
None
None
EDO  A 607 ( 3.9A)
 1.33A 1yvpA-4z2aA:
4.0		 1yvpA-4z2aA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		4 SER A  55
SER A  52
THR A 421
ASN A 422
 None
 1.30A 1yvpA-5ck7A:
4.1		 1yvpA-5ck7A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Homo sapiens) 		PF00903
(Glyoxalase)
PF13669
(Glyoxalase_4) 		4 TYR A 160
SER A  72
SER A  59
THR A  23
 TYR  A 160 ( 1.3A)
SER  A  72 ( 0.0A)
SER  A  59 ( 0.0A)
THR  A  23 ( 0.8A)
 1.19A 1yvpA-5ec3A:
undetectable		 1yvpA-5ec3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8v AMINOTRANSFERASE,
CLASS V FAMILY
PROTEIN

(Trichomonas
vaginalis) 		PF00266
(Aminotran_5) 		4 TYR A 350
SER A 348
THR A 158
ASN A 156
 LLP  A 202 ( 4.0A)
None
LLP  A 202 ( 3.0A)
None
 1.35A 1yvpA-5f8vA:
undetectable		 1yvpA-5f8vA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 TYR B 360
SER B 394
THR B 401
ASN B 354
 None
 1.11A 1yvpA-5fozB:
undetectable		 1yvpA-5fozB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 TYR A 285
SER A 544
THR A 472
ASN A 453
 None
 1.50A 1yvpA-5hqbA:
undetectable		 1yvpA-5hqbA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i84 PHOSPHATE-BINDING
PROTEIN PSTS

(Xanthomonas
citri) 		PF12849
(PBP_like_2) 		4 TYR A 217
SER A 163
SER A 166
ASN A 201
 None
 1.42A 1yvpA-5i84A:
undetectable		 1yvpA-5i84A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 TYR A 255
SER A 238
THR A 202
ASN A 242
 None
 1.49A 1yvpA-5ihrA:
undetectable		 1yvpA-5ihrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8n EXODEOXYRIBONUCLEASE
III

(Methanosarcina
mazei) 		PF03372
(Exo_endo_phos) 		4 TYR A 241
SER A 237
SER A 239
ASN A   6
 None
 1.36A 1yvpA-5j8nA:
undetectable		 1yvpA-5j8nA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		4 SER A 112
SER A 198
THR A 155
ASN A 193
 None
 1.28A 1yvpA-5lhvA:
undetectable		 1yvpA-5lhvA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 4 TYR A 192
SER A 200
SER A 196
THR A 120
 None
AQD  A1201 (-3.6A)
AQD  A1201 (-2.8A)
AQD  A1201 (-4.4A)
 1.32A 1yvpA-5wivA:
undetectable		 1yvpA-5wivA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnn PHOSPHATE-BINDING
PROTEIN PSTS

(Burkholderia
pseudomallei) 		PF12849
(PBP_like_2) 		4 TYR A 213
SER A 159
SER A 162
ASN A 197
 None
PO4  A 400 (-2.5A)
None
PO4  A 400 ( 4.6A)
 1.30A 1yvpA-5wnnA:
undetectable		 1yvpA-5wnnA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvs GDP/UDP-N,N'-DIACETY
LBACILLOSAMINE
2-EPIMERASE
(HYDROLYZING)

(Acinetobacter
baumannii) 		no annotation 4 TYR A 275
SER A 289
SER A 291
THR A 208
 UDP  A 402 (-4.0A)
UDP  A 402 (-3.7A)
UDP  A 402 (-3.3A)
UDP  A 402 ( 4.5A)
 1.43A 1yvpA-5xvsA:
4.7		 1yvpA-5xvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 4 TYR A 258
SER A 303
SER A 290
ASN A 396
 None
 1.11A 1yvpA-6a8mA:
undetectable		 1yvpA-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3p AMY13K

([Eubacterium]
rectale) 		no annotation 4 SER A 362
SER A 364
THR A 182
ASN A 184
 None
FMT  A 422 (-3.2A)
None
None
 1.12A 1yvpA-6b3pA:
undetectable		 1yvpA-6b3pA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 ANTIBODY FAB LIGHT
CHAIN

(Mus musculus) 		no annotation 4 SER B  34
SER B  70
THR B  30
ASN B  28
 None
 1.17A 1yvpA-6c08B:
undetectable		 1yvpA-6c08B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 TYR A 407
SER A 405
THR A 221
ASN A 219
 LLP  A 265 ( 3.7A)
None
LLP  A 265 ( 2.9A)
None
 1.39A 1yvpA-6czxA:
undetectable		 1yvpA-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6er3 BNR/ASP-BOX REPEAT
PROTEIN

([Ruminococcus]
gnavus) 		no annotation 4 SER A  45
SER A 113
THR A 115
ASN A 132
 None
 1.40A 1yvpA-6er3A:
undetectable		 1yvpA-6er3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ged PRGB

(Enterococcus
faecalis) 		no annotation 4 SER A 383
SER A 381
THR A 404
ASN A 389
 None
 1.46A 1yvpA-6gedA:
undetectable		 1yvpA-6gedA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ged PRGB

(Enterococcus
faecalis) 		no annotation 4 SER A 383
SER A 385
THR A 404
ASN A 389
 None
 1.10A 1yvpA-6gedA:
undetectable		 1yvpA-6gedA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8pch CATHEPSIN H

(Sus scrofa) 		PF00112
(Peptidase_C1) 		4 TYR A 149
SER A 153
SER A 151
THR A 138
 None
 1.16A 1yvpA-8pchA:
undetectable		 1yvpA-8pchA:
16.85