SIMILAR PATTERNS OF AMINO ACIDS FOR 1YVM_A_TMGA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exf EXFOLIATVE TOXIN A

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		4 TYR A 183
TYR A 184
HIS A 219
TRP A   3
 None
 1.30A 1yvmA-1exfA:
undetectable		 1yvmA-1exfA:
23.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o0x METHIONINE
AMINOPEPTIDASE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24) 		6 TYR A  65
TYR A  68
CYH A  73
HIS A  82
HIS A 181
TRP A 224
 None
 0.47A 1yvmA-1o0xA:
39.3		 1yvmA-1o0xA:
41.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qxy METHIONYL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00557
(Peptidase_M24) 		4 CYH A  67
HIS A  76
HIS A 175
TRP A 219
 M2C  A3001 ( 4.0A)
M2C  A3001 ( 4.5A)
CO  A1003 ( 3.3A)
None
 0.49A 1yvmA-1qxyA:
35.8		 1yvmA-1qxyA:
34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rie RIESKE IRON-SULFUR
PROTEIN

(Bos taurus) 		PF00355
(Rieske) 		4 CYH A 158
TYR A 157
TYR A 165
CYH A 139
 FES  A 200 ( 2.2A)
None
None
FES  A 200 ( 2.2A)
 1.33A 1yvmA-1rieA:
undetectable		 1yvmA-1rieA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjw ALCOHOL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 CYH A  98
TYR A  97
CYH A  92
HIS A 108
 ZN  A 401 ( 2.3A)
None
ZN  A 401 ( 2.2A)
None
 1.29A 1yvmA-1rjwA:
undetectable		 1yvmA-1rjwA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 CYH A 480
TYR A 484
HIS A 468
TRP A 509
 None
 1.24A 1yvmA-1z6tA:
undetectable		 1yvmA-1z6tA:
18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gtx METHIONINE
AMINOPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		6 CYH A  59
TYR A  62
TYR A  65
CYH A  70
HIS A  79
HIS A 178
 NLP  A3808 ( 3.8A)
NLP  A3808 ( 4.8A)
NLP  A3808 ( 4.0A)
NLP  A3808 ( 3.7A)
NLP  A3808 (-3.8A)
NLP  A3808 (-3.9A)
 0.60A 1yvmA-2gtxA:
47.9		 1yvmA-2gtxA:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gtx METHIONINE
AMINOPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		6 CYH A  59
TYR A  65
CYH A  70
HIS A  79
HIS A 178
TRP A 221
 NLP  A3808 ( 3.8A)
NLP  A3808 ( 4.0A)
NLP  A3808 ( 3.7A)
NLP  A3808 (-3.8A)
NLP  A3808 (-3.9A)
None
 0.58A 1yvmA-2gtxA:
47.9		 1yvmA-2gtxA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9w HYPOTHETICAL PROTEIN

(Psychrobacter
arcticus) 		PF02810
(SEC-C) 		4 CYH A  10
TYR A  60
CYH A  29
HIS A  33
 ZN  A 200 (-2.3A)
None
ZN  A 200 (-2.3A)
None
 1.48A 1yvmA-2i9wA:
undetectable		 1yvmA-2i9wA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzz APOLIPOPROTEIN B
MRNA-EDITING ENZYME,
CATALYTIC
POLYPEPTIDE-LIKE 3G
VARIANT

(synthetic
construct) 		PF08210
(APOBEC_N) 		4 CYH A  25
TYR A  26
TYR A  79
CYH A 144
 None
 1.40A 1yvmA-2mzzA:
undetectable		 1yvmA-2mzzA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7h PUTATIVE D-ALANINE
N-ACETYLTRANSFERASE
OF GNAT FAMILY

(Desulfovibrio
alaskensis) 		PF00583
(Acetyltransf_1) 		4 CYH A  83
TYR A  84
TYR A  67
HIS A  58
 None
 1.22A 1yvmA-2r7hA:
undetectable		 1yvmA-2r7hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d89 RIESKE
DOMAIN-CONTAINING
PROTEIN

(Mus musculus) 		PF13806
(Rieske_2) 		4 CYH A  57
TYR A 145
CYH A  80
HIS A  83
 FES  A 201 (-2.3A)
None
FES  A 201 (-2.3A)
FES  A 201 (-3.2A)
 1.23A 1yvmA-3d89A:
undetectable		 1yvmA-3d89A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1i CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL

(Gallus gallus) 		PF00355
(Rieske)
PF02921
(UCR_TM) 		4 CYH E 158
TYR E 157
TYR E 165
CYH E 139
 FES  E 501 (-2.2A)
None
None
FES  E 501 (-2.2A)
 1.27A 1yvmA-3h1iE:
undetectable		 1yvmA-3h1iE:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzd DPH2

(Pyrococcus
horikoshii) 		PF01866
(Diphthamide_syn) 		4 CYH A 163
TYR A 165
CYH A 287
HIS A 184
 SF4  A 343 (-2.3A)
None
SF4  A 343 (-2.3A)
SO4  A 344 (-4.2A)
 1.40A 1yvmA-3lzdA:
undetectable		 1yvmA-3lzdA:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mr1 METHIONINE
AMINOPEPTIDASE

(Rickettsia
prowazekii) 		PF00557
(Peptidase_M24) 		4 CYH A  68
HIS A  77
HIS A 175
TRP A 219
 None
PO4  A 252 (-4.2A)
PO4  A 252 (-3.7A)
None
 0.82A 1yvmA-3mr1A:
40.7		 1yvmA-3mr1A:
52.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mr1 METHIONINE
AMINOPEPTIDASE

(Rickettsia
prowazekii) 		PF00557
(Peptidase_M24) 		4 TYR A  60
CYH A  68
HIS A  77
HIS A 175
 None
None
PO4  A 252 (-4.2A)
PO4  A 252 (-3.7A)
 0.36A 1yvmA-3mr1A:
40.7		 1yvmA-3mr1A:
52.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s6b METHIONINE
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24) 		4 CYH A 167
HIS A 176
HIS A 277
TRP A 320
 None
 0.71A 1yvmA-3s6bA:
37.0		 1yvmA-3s6bA:
31.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s6b METHIONINE
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24) 		4 TYR A 159
CYH A 167
HIS A 176
HIS A 277
 None
 0.45A 1yvmA-3s6bA:
37.0		 1yvmA-3s6bA:
31.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tav METHIONINE
AMINOPEPTIDASE

(Mycobacteroides
abscessus) 		PF00557
(Peptidase_M24) 		5 TYR A  69
CYH A  77
HIS A  86
HIS A 191
TRP A 234
 LMR  A 271 ( 4.9A)
LMR  A 271 (-3.6A)
LMR  A 271 (-3.9A)
LMR  A 271 (-4.4A)
None
 0.45A 1yvmA-3tavA:
36.9		 1yvmA-3tavA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tb5 METHIONINE
AMINOPEPTIDASE

(Enterococcus
faecalis) 		PF00557
(Peptidase_M24) 		4 TYR A  60
TYR A  63
CYH A  68
HIS A  77
 CIT  A 265 (-4.0A)
None
CIT  A 265 ( 4.5A)
CIT  A 265 (-3.4A)
 0.59A 1yvmA-3tb5A:
40.4		 1yvmA-3tb5A:
38.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tb5 METHIONINE
AMINOPEPTIDASE

(Enterococcus
faecalis) 		PF00557
(Peptidase_M24) 		4 TYR A  63
CYH A  68
HIS A  77
TRP A 218
 None
CIT  A 265 ( 4.5A)
CIT  A 265 (-3.4A)
None
 0.49A 1yvmA-3tb5A:
40.4		 1yvmA-3tb5A:
38.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF16420
(ATG7_N) 		4 CYH A 488
CYH A 572
HIS A 472
HIS A 547
 ZN  A 701 (-2.1A)
ZN  A 701 (-2.1A)
None
None
 1.43A 1yvmA-3vh1A:
undetectable		 1yvmA-3vh1A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vk6 E3 UBIQUITIN-PROTEIN
LIGASE HAKAI

(Mus musculus) 		no annotation 4 CYH A  25
TYR A  14
CYH A   7
HIS A   2
 ZN  A 103 (-2.3A)
None
ZN  A 103 (-2.3A)
None
 1.43A 1yvmA-3vk6A:
undetectable		 1yvmA-3vk6A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 TYR A 106
HIS A  67
HIS A 332
TRP A 102
 None
 1.45A 1yvmA-3w6qA:
undetectable		 1yvmA-3w6qA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvz E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF00628
(PHD) 		4 CYH B 336
CYH B 363
HIS B 319
TRP B 358
 ZN  B 434 (-2.3A)
ZN  B 434 (-2.3A)
None
None
 1.50A 1yvmA-3zvzB:
undetectable		 1yvmA-3zvzB:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aay AROB

(Rhizobium sp.
NT-26) 		PF00355
(Rieske) 		4 CYH B 103
TYR B 168
CYH B 121
HIS B 124
 FES  B2006 (-2.3A)
None
FES  B2006 (-2.2A)
FES  B2006 (-3.0A)
 1.38A 1yvmA-4aayB:
undetectable		 1yvmA-4aayB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 TYR A1323
HIS A1293
HIS A1428
TRP A1319
 None
CUO  A9004 (-3.2A)
CUO  A9004 (-3.4A)
None
 1.46A 1yvmA-4bedA:
undetectable		 1yvmA-4bedA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 TYR B1737
HIS B1705
HIS B1851
TRP B1733
 None
CUO  B9005 (-3.2A)
CUO  B9005 (-3.2A)
None
 1.45A 1yvmA-4bedB:
undetectable		 1yvmA-4bedB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni) 		no annotation 4 TYR A 301
TYR A 300
CYH A 298
HIS A  23
 None
 1.17A 1yvmA-4bg2A:
undetectable		 1yvmA-4bg2A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF01128
(IspD) 		4 CYH A 229
TYR A 226
TYR A 247
HIS A 127
 None
None
None
MG  A1452 (-4.2A)
 1.40A 1yvmA-4cvhA:
undetectable		 1yvmA-4cvhA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fas HYDROXYLAMINE
OXIDOREDUCTASE

(Nitrosomonas
europaea) 		PF13447
(Multi-haem_cyto) 		4 CYH A 172
CYH A 239
HIS A 243
HIS A  99
 HEC  A 603 ( 1.8A)
HEC  A 604 ( 1.8A)
HEC  A 604 (-3.3A)
HEC  A 603 ( 3.2A)
 1.46A 1yvmA-4fasA:
undetectable		 1yvmA-4fasA:
17.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fo7 METHIONINE
AMINOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF00557
(Peptidase_M24) 		5 TYR A  62
CYH A  70
HIS A  79
HIS A 177
TRP A 220
 None
 0.55A 1yvmA-4fo7A:
35.7		 1yvmA-4fo7A:
60.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fuk METHIONINE
AMINOPEPTIDASE

(Trypanosoma
brucei) 		PF00557
(Peptidase_M24) 		5 TYR A 177
CYH A 185
HIS A 194
HIS A 292
TRP A 335
 None
UNX  A 404 ( 3.8A)
None
None
None
 0.73A 1yvmA-4fukA:
36.5		 1yvmA-4fukA:
35.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hxx METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 TYR A 195
CYH A 203
HIS A 212
HIS A 310
TRP A 353
 1AY  A 405 (-4.3A)
1AY  A 405 ( 3.9A)
CO  A 403 ( 3.3A)
1AY  A 405 (-3.4A)
None
 0.65A 1yvmA-4hxxA:
38.5		 1yvmA-4hxxA:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iu6 METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 CYH A 203
HIS A 212
HIS A 310
TRP A 353
 FZ1  A 405 (-3.5A)
CO  A 403 ( 3.1A)
FZ1  A 405 (-3.4A)
None
 0.73A 1yvmA-4iu6A:
38.7		 1yvmA-4iu6A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iu6 METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 TYR A 195
CYH A 203
HIS A 212
HIS A 310
 FZ1  A 405 (-4.4A)
FZ1  A 405 (-3.5A)
CO  A 403 ( 3.1A)
FZ1  A 405 (-3.4A)
 0.44A 1yvmA-4iu6A:
38.7		 1yvmA-4iu6A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4km3 METHIONINE
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF00557
(Peptidase_M24) 		4 TYR A  67
CYH A  72
HIS A  81
TRP A 250
 None
 0.40A 1yvmA-4km3A:
32.5		 1yvmA-4km3A:
35.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7s BTRN

(Bacillus
circulans) 		PF13186
(SPASM) 		4 CYH A  16
CYH A  20
HIS A 117
HIS A  60
 SF4  A 502 (-2.4A)
SF4  A 502 (-2.3A)
SF4  A 502 (-3.8A)
SF4  A 502 ( 4.9A)
 1.22A 1yvmA-4m7sA:
undetectable		 1yvmA-4m7sA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9c BACTERIAL
TRANSFERASE
HEXAPEPTIDE (THREE
REPEATS) FAMILY
PROTEIN

(Acinetobacter
baumannii) 		PF00132
(Hexapep) 		4 CYH A 154
TYR A 135
CYH A 140
HIS A 138
 None
 1.40A 1yvmA-4m9cA:
undetectable		 1yvmA-4m9cA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhb PUTATIVE ALDO/KETO
REDUCTASE

(Yersinia pestis) 		PF00248
(Aldo_ket_red) 		4 TYR A 124
HIS A 121
HIS A 281
TRP A  90
 None
 1.16A 1yvmA-4mhbA:
undetectable		 1yvmA-4mhbA:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		4 CYH A 105
HIS A 114
HIS A 212
TRP A 255
 None
CO  A 303 (-3.4A)
None
None
 0.73A 1yvmA-4ookA:
38.0		 1yvmA-4ookA:
44.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		4 TYR A  97
CYH A 105
HIS A 114
HIS A 212
 None
None
CO  A 303 (-3.4A)
None
 0.53A 1yvmA-4ookA:
38.0		 1yvmA-4ookA:
44.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 CYH A 103
TYR A 102
CYH A  97
HIS A 113
 ZN  A 402 (-2.3A)
None
ZN  A 402 (-2.2A)
None
 1.30A 1yvmA-4w6zA:
undetectable		 1yvmA-4w6zA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xac EVDO2

(Micromonospora
carbonacea) 		PF05721
(PhyH) 		4 TYR A 162
HIS A 129
HIS A 209
TRP A 128
 None
NI  A 301 (-3.3A)
AKG  A 303 (-4.4A)
None
 1.24A 1yvmA-4xacA:
undetectable		 1yvmA-4xacA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpw PRO CATHEPSIN B S9

(Trypanosoma
congolense) 		PF00112
(Peptidase_C1) 		4 TYR A 248
CYH A 300
HIS A 250
TRP A  27
 None
 1.50A 1yvmA-5fpwA:
undetectable		 1yvmA-5fpwA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		4 TYR A  72
HIS A  42
HIS A 208
TRP A  68
 None
ZN  A 301 ( 3.2A)
HQE  A 303 ( 3.0A)
None
 1.45A 1yvmA-5i3aA:
undetectable		 1yvmA-5i3aA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
SMALL SUBUNIT AIOB
RIESKE [2FE-2S]
CLUSTER

(Rhizobium sp.
NT-26) 		no annotation 4 CYH B 103
TYR B 168
CYH B 121
HIS B 124
 FES  B 201 (-2.2A)
None
FES  B 201 (-2.1A)
FES  B 201 (-3.3A)
 1.45A 1yvmA-5nqdB:
undetectable		 1yvmA-5nqdB:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE

(Cupriavidus
metallidurans) 		PF00724
(Oxidored_FMN) 		4 CYH A  25
TYR A  27
HIS A  38
TRP A 114
 FMN  A 401 (-3.1A)
None
None
None
 1.29A 1yvmA-5ocsA:
undetectable		 1yvmA-5ocsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH

(Brachybacterium
faecium) 		PF01636
(APH) 		4 TYR A 246
CYH A 261
HIS A 131
TRP A 254
 None
 1.41A 1yvmA-5uxbA:
undetectable		 1yvmA-5uxbA:
22.33