SIMILAR PATTERNS OF AMINO ACIDS FOR 1YNN_C_RFPC1120

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		5 ARG A  93
SER A 173
LEU A 209
PRO A  68
ILE A  70
 None
 1.17A 1ynnC-1ac5A:
0.0		 1ynnC-1ac5A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE

(Populus tremula) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		5 GLN A 102
GLN A 115
ASP A 269
LEU A 101
ILE A 148
 None
 1.30A 1ynnC-1un1A:
0.0		 1ynnC-1un1A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h01 2-CYS PEROXIREDOXIN

(Plasmodium
yoelii) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 ASP A  71
HIS A  76
LEU A  51
PRO A  45
ILE A  48
 None
 1.20A 1ynnC-2h01A:
0.7		 1ynnC-2h01A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 PHE A 591
ASP A 592
ARG A 783
SER A 777
LEU A 717
 None
 1.36A 1ynnC-2jgdA:
0.0		 1ynnC-2jgdA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsc TRANSCRIPTIONAL
REGULATOR
RV1994C/MT2050

(Mycobacterium
tuberculosis) 		PF01022
(HTH_5) 		5 GLN A  39
ASP A  32
HIS A  43
LEU A  55
ILE A  26
 None
 1.21A 1ynnC-2jscA:
undetectable		 1ynnC-2jscA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 ARG A 829
PHE A 882
ASP A 812
SER A 547
ILE A 543
 None
 1.48A 1ynnC-2pi5A:
0.0		 1ynnC-2pi5A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		5 ARG A 402
SER A 594
LEU A 591
PRO A 552
ILE A 398
 None
 1.47A 1ynnC-3ayxA:
0.4		 1ynnC-3ayxA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLN B 412
ASP B 415
HIS B 425
ARG B 428
PRO B 459
 None
 0.92A 1ynnC-3hkzB:
21.7		 1ynnC-3hkzB:
29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs3 RIBOSE OPERON
REPRESSOR

(Lactobacillus
acidophilus) 		PF13377
(Peripla_BP_3) 		5 ASP A 279
ARG A 315
SER A 317
LEU A 259
ILE A 275
 None
 1.26A 1ynnC-3hs3A:
undetectable		 1ynnC-3hs3A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Listeria
monocytogenes) 		PF02350
(Epimerase_2) 		5 PHE A 377
ASP A 376
ARG A 373
LEU A  95
ILE A 148
 None
 1.46A 1ynnC-3ot5A:
0.0		 1ynnC-3ot5A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvo NMRA FAMILY PROTEIN

(Shigella
flexneri) 		PF13460
(NAD_binding_10) 		5 PHE A 129
ASP A  80
SER A 139
LEU A 141
ILE A  87
 None
 1.08A 1ynnC-3qvoA:
undetectable		 1ynnC-3qvoA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		5 ARG L 403
SER L 601
LEU L 598
PRO L 559
ILE L 399
 None
 1.44A 1ynnC-3rgwL:
0.3		 1ynnC-3rgwL:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugg SUCROSE:(SUCROSE/FRU
CTAN)
6-FRUCTOSYLTRANSFERA
SE

(Pachysandra
terminalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 GLN A 464
PHE A 468
ARG A 325
SER A 502
LEU A 306
 None
 1.38A 1ynnC-3uggA:
undetectable		 1ynnC-3uggA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ASP A 236
ARG A 169
HIS A 159
ARG A 125
LEU A  64
 None
 1.32A 1ynnC-3zz1A:
undetectable		 1ynnC-3zz1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		5 ARG A 405
SER A 583
LEU A 580
PRO A 541
ILE A 401
 None
 1.47A 1ynnC-4c3oA:
undetectable		 1ynnC-4c3oA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 ARG B  67
GLN B  82
GLN B  79
ARG B 143
LEU B 145
 None
 1.48A 1ynnC-4cakB:
undetectable		 1ynnC-4cakB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw1 UNCHARACTERIZED
PROTEIN

([Clostridium]
leptum) 		no annotation 5 GLN A 166
ASP A 168
SER A 248
LEU A  50
ILE A 255
 None
 1.01A 1ynnC-4pw1A:
undetectable		 1ynnC-4pw1A:
13.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ARG B 166
GLN B 425
ASP B 428
HIS B 438
ARG B 441
 None
 0.93A 1ynnC-4qiwB:
27.0		 1ynnC-4qiwB:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twl DIOSCORIN 5

(Dioscorea
japonica) 		PF00194
(Carb_anhydrase) 		5 GLN A 114
PHE A  96
ASP A  70
HIS A  97
SER A  35
 ASC  A 303 (-4.1A)
None
ASC  A 303 (-3.5A)
ASC  A 303 (-4.4A)
None
 1.35A 1ynnC-4twlA:
undetectable		 1ynnC-4twlA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udj UHGB_MP

(uncultured
organism) 		PF04041
(Glyco_hydro_130) 		5 ARG A  14
SER A 246
LEU A 227
PRO A 217
ILE A 229
 None
 1.45A 1ynnC-4udjA:
1.6		 1ynnC-4udjA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN

(Coprinopsis
cinerea) 		PF03664
(Glyco_hydro_62) 		5 ASP A 268
ARG A 273
ARG A 305
SER A 306
LEU A 319
 None
 1.41A 1ynnC-5b6tA:
undetectable		 1ynnC-5b6tA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		5 GLN A 314
SER A 319
LEU A 315
PRO A 222
ILE A 321
 None
 1.46A 1ynnC-5d4kA:
undetectable		 1ynnC-5d4kA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		5 ASP A 403
SER A 371
LEU A 368
PRO A 418
ILE A 407
 None
 1.24A 1ynnC-5fhzA:
0.9		 1ynnC-5fhzA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ASP A 281
ARG A 201
HIS A 191
ARG A 157
LEU A  96
 EDO  A1881 (-3.9A)
None
None
None
None
 1.29A 1ynnC-5fjiA:
0.0		 1ynnC-5fjiA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ASP A 281
ARG A 201
HIS A 191
ARG A 157
LEU A  96
 None
 1.32A 1ynnC-5fjjA:
undetectable		 1ynnC-5fjjA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 GLN A 593
ASP A 736
SER A 610
PRO A 751
ILE A 613
 None
CA  A 903 (-1.9A)
None
None
None
 1.47A 1ynnC-5gz4A:
undetectable		 1ynnC-5gz4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ASP A 277
ARG A 200
HIS A 190
ARG A 156
LEU A  95
 BGC  A 946 (-2.8A)
BGC  A 946 (-3.9A)
BGC  A 946 (-3.7A)
BGC  A 946 (-2.9A)
None
 1.27A 1ynnC-5ju6A:
undetectable		 1ynnC-5ju6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 5 ASP A 276
ARG A 196
HIS A 186
ARG A 152
LEU A  91
 None
 1.28A 1ynnC-5nbsA:
undetectable		 1ynnC-5nbsA:
5.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		11 ARG C 164
GLN C 426
GLN C 429
ASP C 432
ARG C 604
HIS C 442
ARG C 445
SER C 447
LEU C 449
PRO C 480
ILE C 488
 None
 1.11A 1ynnC-5tw1C:
40.7		 1ynnC-5tw1C:
50.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		6 GLN C 429
PHE C 430
HIS C 442
ARG C 445
PRO C 480
ILE C 488
 None
 1.04A 1ynnC-5tw1C:
40.7		 1ynnC-5tw1C:
50.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 5 ASP B   8
SER B 201
LEU B 193
PRO B 209
ILE B 204
 None
 1.24A 1ynnC-6czaB:
undetectable		 1ynnC-6czaB:
undetectable