SIMILAR PATTERNS OF AMINO ACIDS FOR 1YC5_A_NCAA2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dus MJ0882

(Methanocaldococcus
jannaschii)
PF05175
(MTS)
4 ASP A  31
ASN A  86
ILE A  90
ASP A  84
None
1.01A 1yc5A-1dusA:
3.3
1yc5A-1dusA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 ALA A 466
SER A 463
ILE A 445
ASP A 441
None
0.88A 1yc5A-1g8kA:
3.1
1yc5A-1g8kA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i78 PROTEASE VII

(Escherichia
coli)
PF01278
(Omptin)
4 ILE A 219
ASP A 214
ASN A 269
ASP A 267
None
0.91A 1yc5A-1i78A:
undetectable
1yc5A-1i78A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im8 YECO

(Haemophilus
influenzae)
PF13649
(Methyltransf_25)
4 ALA A  69
SER A  72
ASP A  61
ILE A  41
SAI  A 302 ( 3.9A)
None
SAI  A 302 ( 4.8A)
None
0.94A 1yc5A-1im8A:
3.2
1yc5A-1im8A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jru P47 PROTEIN

(Rattus
norvegicus)
PF00789
(UBX)
4 SER A 284
ILE A 287
ILE A 321
ASP A 320
None
0.93A 1yc5A-1jruA:
undetectable
1yc5A-1jruA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT


(Klebsiella
pneumoniae)
PF08841
(DDR)
4 ALA A  17
SER A  31
ASN A 594
ILE A 586
None
0.89A 1yc5A-1nbwA:
2.6
1yc5A-1nbwA:
17.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q14 HST2 PROTEIN

(Saccharomyces
cerevisiae)
PF02146
(SIR2)
5 ALA A  33
SER A  36
ASN A 116
ILE A 117
ASP A 118
None
0.21A 1yc5A-1q14A:
23.5
1yc5A-1q14A:
34.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae)
PF02146
(SIR2)
6 ALA A  33
SER A  36
ILE A  41
ASN A 116
ILE A 117
ASP A 118
OAD  A1001 (-3.9A)
None
None
None
OAD  A1001 ( 4.4A)
None
0.20A 1yc5A-1q1aA:
25.4
1yc5A-1q1aA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae)
PF02146
(SIR2)
4 SER A  36
ILE A  41
ASP A  43
ASP A 118
None
None
OAD  A1001 (-3.8A)
None
0.84A 1yc5A-1q1aA:
25.4
1yc5A-1q1aA:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s5p NAD-DEPENDENT
DEACETYLASE


(Escherichia
coli)
PF02146
(SIR2)
6 ALA A  49
SER A  52
ILE A  57
ASN A 130
ILE A 131
ASP A 132
None
0.34A 1yc5A-1s5pA:
20.2
1yc5A-1s5pA:
33.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s7g NAD-DEPENDENT
DEACETYLASE 2


(Archaeoglobus
fulgidus)
PF02146
(SIR2)
6 ALA A  24
SER A  27
ILE A  32
ASN A 101
ILE A 102
ASP A 103
NAD  A 703 (-3.8A)
None
1PE  A 504 ( 4.7A)
None
None
None
0.29A 1yc5A-1s7gA:
27.6
1yc5A-1s7gA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tba TRANSCRIPTION
INITIATION FACTOR
IID 230K CHAIN
TRANSCRIPTION
INITIATION FACTOR
TFIID


(Drosophila
melanogaster;
Saccharomyces
cerevisiae)
PF09247
(TBP-binding)
PF00352
(TBP)
4 ALA B 113
ILE B 103
ILE A  28
ASP A  29
None
1.02A 1yc5A-1tbaB:
undetectable
1yc5A-1tbaB:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG


(Bacillus
subtilis)
PF05690
(ThiG)
4 ALA A 285
ILE A 287
ASP A 284
ILE A 264
PO4  A1400 (-3.8A)
None
None
None
0.97A 1yc5A-1tygA:
undetectable
1yc5A-1tygA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE


(Ruminiclostridium
thermocellum)
PF00331
(Glyco_hydro_10)
4 ALA A 700
SER A 698
ILE A 691
ILE A 705
None
0.99A 1yc5A-1xyzA:
undetectable
1yc5A-1xyzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT


(Methylococcus
capsulatus)
PF02461
(AMO)
4 ALA B 122
ASP B  49
ASN B 160
ILE B 164
None
0.99A 1yc5A-1yewB:
undetectable
1yc5A-1yewB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT


(Homo sapiens)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
4 SER A 363
ILE A 362
ASP A 382
ASP A 360
None
0.84A 1yc5A-1z68A:
undetectable
1yc5A-1z68A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT


(Klebsiella
oxytoca)
PF08841
(DDR)
4 ALA A  17
SER A  32
ASN A 592
ILE A 584
None
0.88A 1yc5A-2d0oA:
2.5
1yc5A-2d0oA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpk SODIUM/CALCIUM
EXCHANGER 1


(Canis lupus)
PF03160
(Calx-beta)
4 ILE A 496
ASP A 499
ILE A 445
ASP A 421
None
CA  A4001 (-2.7A)
None
CA  A1001 ( 2.5A)
0.85A 1yc5A-2dpkA:
undetectable
1yc5A-2dpkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgn PHOSPHOLIPASE C

(Bacillus cereus)
PF00882
(Zn_dep_PLPC)
4 ALA A   3
ILE A  51
ASP A  55
ILE A  17
None
None
ZN  A 246 (-2.6A)
None
0.78A 1yc5A-2fgnA:
undetectable
1yc5A-2fgnA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2


(Saccharomyces
cerevisiae)
PF02146
(SIR2)
PF04574
(DUF592)
6 ALA A 263
SER A 266
ILE A 271
ASN A 345
ILE A 346
ASP A 347
XYQ  A1222 (-3.4A)
None
NCA  A 900 (-4.6A)
None
NCA  A 900 (-4.6A)
None
0.51A 1yc5A-2hjhA:
20.2
1yc5A-2hjhA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2


(Saccharomyces
cerevisiae)
PF02146
(SIR2)
PF04574
(DUF592)
4 SER A 266
ILE A 271
ASP A 273
ASP A 347
None
NCA  A 900 (-4.6A)
XYQ  A1222 (-3.7A)
None
0.79A 1yc5A-2hjhA:
20.2
1yc5A-2hjhA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL


(Homo sapiens)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
4 ALA A 129
SER A 132
ILE A 133
ILE A  86
None
0.70A 1yc5A-2iikA:
undetectable
1yc5A-2iikA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjp PYROPHOSPHATASE

(Methanocaldococcus
jannaschii)
PF01725
(Ham1p_like)
4 ALA A 150
SER A 153
ASN A  98
ILE A 101
None
0.86A 1yc5A-2mjpA:
undetectable
1yc5A-2mjpA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5j MAJOR CAPSID PROTEIN
L1


(Alphapapillomavirus
9)
PF00500
(Late_protein_L1)
4 ALA A 345
SER A 347
ASN A 357
ASP A 350
None
0.90A 1yc5A-2r5jA:
undetectable
1yc5A-2r5jA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E


(Fusarium
graminearum)
PF02458
(Transferase)
4 ALA A  95
ILE A 144
ASP A  92
ILE A 116
None
1.00A 1yc5A-2rkvA:
undetectable
1yc5A-2rkvA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyk PROTEIN TDCF

(Escherichia
coli)
PF01042
(Ribonuc_L-PSP)
4 ALA A  50
SER A  53
ILE A 121
ILE A  78
None
0.87A 1yc5A-2uykA:
undetectable
1yc5A-2uykA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v15 DNA PROTECTION
DURING STARVATION
PROTEIN


(Streptococcus
suis)
PF00210
(Ferritin)
4 ALA A 151
SER A 154
ILE A 155
ILE A  69
None
0.71A 1yc5A-2v15A:
undetectable
1yc5A-2v15A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xok ATP SYNTHASE SUBUNIT
GAMMA, MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF00231
(ATP-synt)
4 ALA G 215
SER G 143
ILE G 146
ILE G 164
None
1.01A 1yc5A-2xokG:
undetectable
1yc5A-2xokG:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrl KIAA1837 PROTEIN

(Homo sapiens)
PF00801
(PKD)
4 ALA A   9
SER A  32
ILE A  37
ASP A  79
None
0.98A 1yc5A-2yrlA:
undetectable
1yc5A-2yrlA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brz TODX

(Pseudomonas
putida)
PF03349
(Toluene_X)
4 ALA A 237
SER A  21
ILE A 299
ASP A 298
None
0.96A 1yc5A-3brzA:
undetectable
1yc5A-3brzA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpr DIHYDRODIPICOLINATE
SYNTHETASE


(Corynebacterium
glutamicum)
PF00701
(DHDPS)
4 ALA A 285
SER A 263
ILE A 283
ASP A 278
None
0.95A 1yc5A-3cprA:
undetectable
1yc5A-3cprA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE


(Desulfitobacterium
hafniense)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 ALA A 323
SER A 326
ASP A 109
ILE A  92
None
0.95A 1yc5A-3db2A:
3.1
1yc5A-3db2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE


(Bacteroides
thetaiotaomicron)
PF13419
(HAD_2)
4 SER A  68
ILE A  67
ASN A  54
ILE A  57
GOL  A 235 ( 4.9A)
None
None
None
0.84A 1yc5A-3ddhA:
5.1
1yc5A-3ddhA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g14 NITROREDUCTASE
FAMILY PROTEIN


(Clostridium
novyi)
PF00881
(Nitroreductase)
4 ALA A 135
ILE A 132
ASP A  58
ILE A  48
None
1.02A 1yc5A-3g14A:
undetectable
1yc5A-3g14A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE


(Clostridioides
difficile)
PF01380
(SIS)
4 SER A 113
ILE A 129
ASP A 127
ASP A 123
None
1.01A 1yc5A-3g68A:
4.4
1yc5A-3g68A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
4 ILE A 201
ASN A 157
ILE A 158
ASP A 159
None
0.87A 1yc5A-3gwjA:
undetectable
1yc5A-3gwjA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgo 12-OXOPHYTODIENOATE
REDUCTASE 3


(Solanum
lycopersicum)
PF00724
(Oxidored_FMN)
4 SER A 134
ILE A 133
ILE A 200
ASP A 246
None
1.02A 1yc5A-3hgoA:
undetectable
1yc5A-3hgoA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuo ATP-DEPENDENT DNA
HELICASE RECQ


(Porphyromonas
gingivalis)
no annotation 4 ALA A 637
ILE A 641
ASP A 639
ILE A 668
None
0.91A 1yc5A-3iuoA:
undetectable
1yc5A-3iuoA:
22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jr3 NAD-DEPENDENT
DEACETYLASE


(Thermotoga
maritima)
PF02146
(SIR2)
7 ALA A  22
SER A  25
ILE A  30
ASP A  32
ASN A  99
ILE A 100
ASP A 101
None
0.25A 1yc5A-3jr3A:
40.5
1yc5A-3jr3A:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js6 UNCHARACTERIZED PARM
PROTEIN


(Staphylococcus
aureus)
no annotation 4 SER A 187
ILE A 294
ASP A 292
ILE A 288
None
0.96A 1yc5A-3js6A:
undetectable
1yc5A-3js6A:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jwp TRANSCRIPTIONAL
REGULATORY PROTEIN
SIR2 HOMOLOGUE


(Plasmodium
falciparum)
PF02146
(SIR2)
4 SER A  32
ILE A  37
ASN A 107
ASP A 109
None
0.37A 1yc5A-3jwpA:
19.9
1yc5A-3jwpA:
31.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll9 ISOPENTENYL
PHOSPHATE KINASE


(Methanothermobacter
thermautotrophicus)
PF00696
(AA_kinase)
4 ALA A 243
ASN A  25
ILE A  11
ASP A  22
None
0.78A 1yc5A-3ll9A:
3.6
1yc5A-3ll9A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6


(Homo sapiens)
PF02146
(SIR2)
5 ALA A  51
SER A  54
ILE A  59
ASN A 112
ASP A 114
A2N  A1000 (-3.5A)
None
None
None
None
0.43A 1yc5A-3pkjA:
24.7
1yc5A-3pkjA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6


(Homo sapiens)
PF02146
(SIR2)
4 SER A  54
ILE A  59
ASP A  61
ASP A 114
None
None
A2N  A1000 (-4.0A)
None
0.82A 1yc5A-3pkjA:
24.7
1yc5A-3pkjA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb5 NA/CA EXCHANGE
PROTEIN


(Drosophila
melanogaster)
PF03160
(Calx-beta)
4 ALA A 474
ILE A 442
ILE A 470
ASP A 469
None
0.93A 1yc5A-3rb5A:
undetectable
1yc5A-3rb5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE


(Methanocaldococcus
jannaschii)
PF00171
(Aldedh)
4 SER A 286
ILE A 287
ASP A 289
ASP A 284
None
1.00A 1yc5A-3rhdA:
3.8
1yc5A-3rhdA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE


(Synechocystis
sp. PCC 6803)
PF03320
(FBPase_glpX)
4 ALA A 204
SER A 206
ILE A 214
ILE A 196
None
0.87A 1yc5A-3rplA:
undetectable
1yc5A-3rplA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3


(Thermococcus
kodakarensis)
PF01876
(RNase_P_p30)
4 ALA A 205
SER A 208
ILE A 175
ILE A 198
None
0.76A 1yc5A-3wyzA:
undetectable
1yc5A-3wyzA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6


(Homo sapiens)
PF02146
(SIR2)
5 ALA A  51
SER A  54
ILE A  59
ASN A 112
ASP A 114
APR  A1296 (-3.7A)
None
None
None
None
0.36A 1yc5A-3zg6A:
23.7
1yc5A-3zg6A:
34.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6


(Homo sapiens)
PF02146
(SIR2)
4 SER A  54
ILE A  59
ASP A  61
ASP A 114
None
None
GOL  A1299 ( 3.1A)
None
0.81A 1yc5A-3zg6A:
23.7
1yc5A-3zg6A:
34.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE


(Streptococcus
pneumoniae)
PF00728
(Glyco_hydro_20)
4 ALA A 245
SER A 236
ASP A 248
ASP A 234
None
0.90A 1yc5A-4az7A:
undetectable
1yc5A-4az7A:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL


(Homo sapiens)
PF02146
(SIR2)
5 ALA A 146
SER A 149
ASN A 229
ILE A 230
ASP A 231
CNA  A1395 (-3.1A)
CNA  A1395 (-4.3A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
0.37A 1yc5A-4bn5A:
24.6
1yc5A-4bn5A:
36.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL


(Homo sapiens)
PF02146
(SIR2)
5 ALA A 146
SER A 149
ILE A 154
ASN A 229
ASP A 231
CNA  A1395 (-3.1A)
CNA  A1395 (-4.3A)
CNA  A1395 (-3.8A)
CNA  A1395 (-3.7A)
CNA  A1395 (-3.5A)
0.39A 1yc5A-4bn5A:
24.6
1yc5A-4bn5A:
36.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cn8 PROXIMAL THREAD
MATRIX PROTEIN 1


(Mytilus
galloprovincialis)
PF00092
(VWA)
4 SER A  62
ILE A  65
ILE A 201
ASP A 173
None
0.97A 1yc5A-4cn8A:
5.2
1yc5A-4cn8A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN


(Plasmodium
falciparum)
PF00092
(VWA)
4 SER A  56
ILE A  59
ILE A 190
ASP A 162
None
1.00A 1yc5A-4f1kA:
4.5
1yc5A-4f1kA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A


(Catenulispora
acidiphila)
PF13768
(VWA_3)
4 ALA A 132
ASP A  67
ILE A  60
ASP A  61
None
None
None
NA  A 501 ( 3.8A)
0.95A 1yc5A-4fx5A:
4.8
1yc5A-4fx5A:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL


(Homo sapiens)
PF02146
(SIR2)
5 ALA A  59
SER A  62
ASN A 141
ILE A 142
ASP A 143
CNA  A 402 (-3.0A)
CNA  A 402 ( 4.1A)
CNA  A 402 (-4.1A)
CNA  A 402 (-4.7A)
CNA  A 402 (-3.7A)
0.27A 1yc5A-4g1cA:
24.9
1yc5A-4g1cA:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE


(Escherichia
coli)
PF13649
(Methyltransf_25)
4 ALA A  70
SER A  73
ASP A  62
ILE A  42
GEK  A 302 ( 4.1A)
None
GEK  A 302 ( 4.5A)
None
0.93A 1yc5A-4gekA:
2.8
1yc5A-4gekA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis)
no annotation 4 ALA A  43
ILE A 113
ASN A  45
ILE A  46
None
0.92A 1yc5A-4gk9A:
undetectable
1yc5A-4gk9A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9


(Saccharomyces
cerevisiae)
PF00022
(Actin)
4 ILE B  73
ASP B  75
ILE B 126
ASP B 123
None
0.90A 1yc5A-4i6mB:
undetectable
1yc5A-4i6mB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2


(Saccharomyces
cerevisiae)
PF02146
(SIR2)
PF04574
(DUF592)
6 ALA A 263
SER A 266
ILE A 271
ASN A 345
ILE A 346
ASP A 347
APR  A 602 (-3.3A)
None
None
None
None
None
0.48A 1yc5A-4iaoA:
20.9
1yc5A-4iaoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2


(Saccharomyces
cerevisiae)
PF02146
(SIR2)
PF04574
(DUF592)
4 SER A 266
ILE A 271
ASP A 273
ASP A 347
None
None
APR  A 602 (-3.9A)
None
0.84A 1yc5A-4iaoA:
20.9
1yc5A-4iaoA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1


(Homo sapiens)
PF02146
(SIR2)
5 ALA A 262
SER A 265
ASN A 346
ILE A 347
ASP A 348
None
0.27A 1yc5A-4ig9A:
21.8
1yc5A-4ig9A:
34.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1


(Homo sapiens)
PF02146
(SIR2)
5 SER A 265
ILE A 270
ASN A 346
ILE A 347
ASP A 348
None
0.62A 1yc5A-4ig9A:
21.8
1yc5A-4ig9A:
34.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB
YENC2


(Yersinia
entomophaga;
Yersinia
entomophaga)
PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
no annotation
4 ILE A1088
ASN B  77
ILE B  79
ASP B  73
None
1.00A 1yc5A-4iglA:
undetectable
1yc5A-4iglA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius)
PF00437
(T2SSE)
4 ALA A  77
SER A  79
ILE A  80
ILE A  96
None
0.91A 1yc5A-4ihqA:
2.6
1yc5A-4ihqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivf PUTATIVE
UNCHARACTERIZED
PROTEIN


(Lodderomyces
elongisporus)
PF00043
(GST_C)
PF02798
(GST_N)
4 ILE A   8
ASP A  31
ASN A  65
ASP A  63
None
0.98A 1yc5A-4ivfA:
undetectable
1yc5A-4ivfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE


(Escherichia
coli)
PF13649
(Methyltransf_25)
4 ALA A  70
SER A  73
ASP A  62
ILE A  42
GEK  A 301 ( 4.1A)
None
GEK  A 301 ( 4.5A)
None
0.88A 1yc5A-4iwnA:
2.9
1yc5A-4iwnA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE


(Coxiella
burnetii)
PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase)
4 ALA A 589
ILE A 600
ASP A 591
ILE A 582
None
0.99A 1yc5A-4nbqA:
undetectable
1yc5A-4nbqA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5f TYPE III
PANTOTHENATE KINASE


(Burkholderia
thailandensis)
PF03309
(Pan_kinase)
4 ALA A  60
ILE A  15
ASN A  54
ILE A  52
None
0.96A 1yc5A-4o5fA:
undetectable
1yc5A-4o5fA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens)
PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
4 ALA A1958
SER A1942
ASP A1956
ASP A1961
None
0.85A 1yc5A-4o9xA:
undetectable
1yc5A-4o9xA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okr MICRONEMAL PROTEIN
MIC2


(Toxoplasma
gondii)
PF00090
(TSP_1)
PF00092
(VWA)
4 SER A  84
ILE A  87
ILE A  81
ASP A  82
None
0.99A 1yc5A-4okrA:
3.8
1yc5A-4okrA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oku MICRONEMAL PROTEIN
MIC2


(Toxoplasma
gondii)
PF00090
(TSP_1)
PF00092
(VWA)
4 SER A  84
ILE A  87
ILE A  81
ASP A  82
None
1.00A 1yc5A-4okuA:
3.7
1yc5A-4okuA:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1


(Archaeoglobus
fulgidus)
PF02146
(SIR2)
5 ALA A  21
SER A  24
ILE A  29
ASN A  99
ASP A 101
None
0.49A 1yc5A-4twiA:
27.9
1yc5A-4twiA:
40.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB


(Lactococcus
lactis)
PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C)
4 SER A 552
ASN A 535
ILE A 536
ASP A 550
None
0.89A 1yc5A-4wd9A:
undetectable
1yc5A-4wd9A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8i LYSYL AMINOPEPTIDASE

(Pyrococcus
furiosus)
PF05343
(Peptidase_M42)
4 ALA A 214
ASN A  46
ILE A  48
ASP A  42
None
0.99A 1yc5A-4x8iA:
undetectable
1yc5A-4x8iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
4 ALA A 472
SER A 474
ILE A 427
ASP A 431
None
0.85A 1yc5A-4xriA:
undetectable
1yc5A-4xriA:
15.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2


(Homo sapiens)
PF02146
(SIR2)
7 ALA A  85
SER A  88
ILE A  93
ASP A  95
ASN A 168
ILE A 169
ASP A 170
None
0.38A 1yc5A-4y6oA:
10.7
1yc5A-4y6oA:
34.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
4 ALA A 401
SER A 443
ILE A 444
ILE A 448
None
0.87A 1yc5A-4ypjA:
undetectable
1yc5A-4ypjA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1


(Homo sapiens)
PF02146
(SIR2)
5 ALA A 262
SER A 265
ASN A 346
ILE A 347
ASP A 348
None
0.27A 1yc5A-4zzhA:
20.9
1yc5A-4zzhA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1


(Homo sapiens)
PF02146
(SIR2)
5 SER A 265
ILE A 270
ASN A 346
ILE A 347
ASP A 348
None
0.53A 1yc5A-4zzhA:
20.9
1yc5A-4zzhA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE


(Vesicular
stomatitis
virus)
PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap)
4 SER A1771
ILE A1774
ASN A1807
ILE A1811
None
0.89A 1yc5A-5a22A:
2.6
1yc5A-5a22A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3c SIR2 FAMILY PROTEIN

(Streptococcus
pyogenes)
no annotation 4 ALA A  34
SER A  37
ASN A 118
ASP A 120
NAD  A1294 (-3.3A)
NAD  A1294 ( 4.1A)
NAD  A1294 (-3.9A)
NAD  A1294 (-3.9A)
0.31A 1yc5A-5a3cA:
13.1
1yc5A-5a3cA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1


(Homo sapiens)
PF02146
(SIR2)
6 ALA A 262
SER A 265
ILE A 270
ASN A 346
ILE A 347
ASP A 348
None
0.29A 1yc5A-5btrA:
20.7
1yc5A-5btrA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT


(Azospira oryzae)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 ALA A 753
ILE A 501
ILE A 505
ASP A 504
None
0.99A 1yc5A-5chcA:
3.8
1yc5A-5chcA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29)
PF16838
(Caud_tail_N)
4 ASP A 311
ASN A 354
ILE A 352
ASP A 377
None
0.64A 1yc5A-5feiA:
undetectable
1yc5A-5feiA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron)
PF12771
(SusD-like_2)
4 SER A 310
ILE A 311
ILE A 307
ASP A 308
None
1.01A 1yc5A-5fq6A:
undetectable
1yc5A-5fq6A:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2


(Homo sapiens)
PF02146
(SIR2)
7 ALA A  85
SER A  88
ILE A  93
ASP A  95
ASN A 168
ILE A 169
ASP A 170
SO4  A1357 ( 4.1A)
None
None
SO4  A1357 ( 4.8A)
None
None
None
0.25A 1yc5A-5fyqA:
22.0
1yc5A-5fyqA:
30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7r PUTATIVE LIPOPROTEIN

(Clostridium
perfringens)
PF10646
(Germane)
4 SER A 146
ILE A 144
ILE A  42
ASP A  72
None
0.85A 1yc5A-5j7rA:
undetectable
1yc5A-5j7rA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE


(Xenopus
tropicalis)
no annotation 5 ALA A  62
SER A  65
ILE A  70
ASN A 143
ASP A 145
AR6  A 401 (-3.6A)
None
None
None
None
0.30A 1yc5A-5oj7A:
8.9
1yc5A-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE


(Xenopus
tropicalis)
no annotation 5 SER A  65
ILE A  70
ASP A  72
ASN A 143
ASP A 145
None
None
AR6  A 401 (-3.7A)
None
None
0.76A 1yc5A-5oj7A:
8.9
1yc5A-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oji DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4


(Caenorhabditis
elegans)
no annotation 4 ALA A 231
ILE A  22
ASP A 228
ILE A 252
None
NAP  A 301 (-3.5A)
None
None
1.02A 1yc5A-5ojiA:
4.1
1yc5A-5ojiA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2


(Leishmania
infantum)
no annotation 6 ALA A  40
SER A  43
ILE A  48
ASN A 125
ILE A 126
ASP A 127
None
0.28A 1yc5A-5ol0A:
9.4
1yc5A-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7


(Saccharomyces
cerevisiae)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
4 ALA 7 567
ASP 7 527
ILE 7 523
ASP 7 524
None
0.99A 1yc5A-5v8f7:
undetectable
1yc5A-5v8f7:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj2 NON-STRUCTURAL
PROTEIN 1


(Respiratory
syncytial virus)
PF03438
(Pneumo_NS1)
4 ALA A  40
SER A  63
ILE A  65
ILE A  35
None
CL  A 205 (-2.9A)
None
None
0.92A 1yc5A-5vj2A:
undetectable
1yc5A-5vj2A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT


(Oryctolagus
cuniculus)
no annotation 4 ALA B 265
SER B 301
ASP B 296
ASN B 335
None
0.74A 1yc5A-5w7aB:
undetectable
1yc5A-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2


(Leptotrichia
shahii)
no annotation 4 SER A 841
ILE A 877
ASN A 622
ILE A 623
None
0.95A 1yc5A-5wtkA:
undetectable
1yc5A-5wtkA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3


(Homo sapiens)
PF00557
(Peptidase_M24)
PF05195
(AMP_N)
4 SER A 489
ILE A 487
ILE A 450
ASP A 476
None
0.94A 1yc5A-5x49A:
undetectable
1yc5A-5x49A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6enx NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL


(Danio rerio)
no annotation 5 ALA A  55
SER A  58
ASN A 137
ILE A 138
ASP A 139
BJW  A 303 (-3.5A)
None
None
BJW  A 303 (-3.9A)
None
0.32A 1yc5A-6enxA:
24.0
1yc5A-6enxA:
32.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gmb HYDROXYACID OXIDASE
1


(Homo sapiens)
no annotation 4 SER A 216
ILE A 217
ILE A 213
ASP A 214
None
0.99A 1yc5A-6gmbA:
undetectable
1yc5A-6gmbA:
undetectable