SIMILAR PATTERNS OF AMINO ACIDS FOR 1YC5_A_NCAA2001
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dus | MJ0882 (Methanocaldococcusjannaschii) |
PF05175(MTS) | 4 | ASP A 31ASN A 86ILE A 90ASP A 84 | None | 1.01A | 1yc5A-1dusA:3.3 | 1yc5A-1dusA:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8k | ARSENITE OXIDASE (Alcaligenesfaecalis) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | ALA A 466SER A 463ILE A 445ASP A 441 | None | 0.88A | 1yc5A-1g8kA:3.1 | 1yc5A-1g8kA:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i78 | PROTEASE VII (Escherichiacoli) |
PF01278(Omptin) | 4 | ILE A 219ASP A 214ASN A 269ASP A 267 | None | 0.91A | 1yc5A-1i78A:undetectable | 1yc5A-1i78A:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1im8 | YECO (Haemophilusinfluenzae) |
PF13649(Methyltransf_25) | 4 | ALA A 69SER A 72ASP A 61ILE A 41 | SAI A 302 ( 3.9A)NoneSAI A 302 ( 4.8A)None | 0.94A | 1yc5A-1im8A:3.2 | 1yc5A-1im8A:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jru | P47 PROTEIN (Rattusnorvegicus) |
PF00789(UBX) | 4 | SER A 284ILE A 287ILE A 321ASP A 320 | None | 0.93A | 1yc5A-1jruA:undetectable | 1yc5A-1jruA:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nbw | GLYCEROL DEHYDRATASEREACTIVASE ALPHASUBUNIT (Klebsiellapneumoniae) |
PF08841(DDR) | 4 | ALA A 17SER A 31ASN A 594ILE A 586 | None | 0.89A | 1yc5A-1nbwA:2.6 | 1yc5A-1nbwA:17.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q14 | HST2 PROTEIN (Saccharomycescerevisiae) |
PF02146(SIR2) | 5 | ALA A 33SER A 36ASN A 116ILE A 117ASP A 118 | None | 0.21A | 1yc5A-1q14A:23.5 | 1yc5A-1q14A:34.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q1a | HST2 PROTEIN (Saccharomycescerevisiae) |
PF02146(SIR2) | 6 | ALA A 33SER A 36ILE A 41ASN A 116ILE A 117ASP A 118 | OAD A1001 (-3.9A)NoneNoneNoneOAD A1001 ( 4.4A)None | 0.20A | 1yc5A-1q1aA:25.4 | 1yc5A-1q1aA:37.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q1a | HST2 PROTEIN (Saccharomycescerevisiae) |
PF02146(SIR2) | 4 | SER A 36ILE A 41ASP A 43ASP A 118 | NoneNoneOAD A1001 (-3.8A)None | 0.84A | 1yc5A-1q1aA:25.4 | 1yc5A-1q1aA:37.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1s5p | NAD-DEPENDENTDEACETYLASE (Escherichiacoli) |
PF02146(SIR2) | 6 | ALA A 49SER A 52ILE A 57ASN A 130ILE A 131ASP A 132 | None | 0.34A | 1yc5A-1s5pA:20.2 | 1yc5A-1s5pA:33.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1s7g | NAD-DEPENDENTDEACETYLASE 2 (Archaeoglobusfulgidus) |
PF02146(SIR2) | 6 | ALA A 24SER A 27ILE A 32ASN A 101ILE A 102ASP A 103 | NAD A 703 (-3.8A)None1PE A 504 ( 4.7A)NoneNoneNone | 0.29A | 1yc5A-1s7gA:27.6 | 1yc5A-1s7gA:42.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tba | TRANSCRIPTIONINITIATION FACTORIID 230K CHAINTRANSCRIPTIONINITIATION FACTORTFIID (Drosophilamelanogaster;Saccharomycescerevisiae) |
PF09247(TBP-binding)PF00352(TBP) | 4 | ALA B 113ILE B 103ILE A 28ASP A 29 | None | 1.02A | 1yc5A-1tbaB:undetectable | 1yc5A-1tbaB:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tyg | THIAZOLEBIOSYNTHESIS PROTEINTHIG (Bacillussubtilis) |
PF05690(ThiG) | 4 | ALA A 285ILE A 287ASP A 284ILE A 264 | PO4 A1400 (-3.8A)NoneNoneNone | 0.97A | 1yc5A-1tygA:undetectable | 1yc5A-1tygA:24.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xyz | 1,4-BETA-D-XYLAN-XYLANOHYDROLASE (Ruminiclostridiumthermocellum) |
PF00331(Glyco_hydro_10) | 4 | ALA A 700SER A 698ILE A 691ILE A 705 | None | 0.99A | 1yc5A-1xyzA:undetectable | 1yc5A-1xyzA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yew | PARTICULATE METHANEMONOOXYGENASE, ASUBUNIT (Methylococcuscapsulatus) |
PF02461(AMO) | 4 | ALA B 122ASP B 49ASN B 160ILE B 164 | None | 0.99A | 1yc5A-1yewB:undetectable | 1yc5A-1yewB:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z68 | FIBROBLASTACTIVATION PROTEIN,ALPHA SUBUNIT (Homo sapiens) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 4 | SER A 363ILE A 362ASP A 382ASP A 360 | None | 0.84A | 1yc5A-1z68A:undetectable | 1yc5A-1z68A:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0o | DIOLDEHYDRATASE-REACTIVATING FACTOR LARGESUBUNIT (Klebsiellaoxytoca) |
PF08841(DDR) | 4 | ALA A 17SER A 32ASN A 592ILE A 584 | None | 0.88A | 1yc5A-2d0oA:2.5 | 1yc5A-2d0oA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpk | SODIUM/CALCIUMEXCHANGER 1 (Canis lupus) |
PF03160(Calx-beta) | 4 | ILE A 496ASP A 499ILE A 445ASP A 421 | None CA A4001 (-2.7A)None CA A1001 ( 2.5A) | 0.85A | 1yc5A-2dpkA:undetectable | 1yc5A-2dpkA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fgn | PHOSPHOLIPASE C (Bacillus cereus) |
PF00882(Zn_dep_PLPC) | 4 | ALA A 3ILE A 51ASP A 55ILE A 17 | NoneNone ZN A 246 (-2.6A)None | 0.78A | 1yc5A-2fgnA:undetectable | 1yc5A-2fgnA:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hjh | NAD-DEPENDENTHISTONE DEACETYLASESIR2 (Saccharomycescerevisiae) |
PF02146(SIR2)PF04574(DUF592) | 6 | ALA A 263SER A 266ILE A 271ASN A 345ILE A 346ASP A 347 | XYQ A1222 (-3.4A)NoneNCA A 900 (-4.6A)NoneNCA A 900 (-4.6A)None | 0.51A | 1yc5A-2hjhA:20.2 | 1yc5A-2hjhA:27.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hjh | NAD-DEPENDENTHISTONE DEACETYLASESIR2 (Saccharomycescerevisiae) |
PF02146(SIR2)PF04574(DUF592) | 4 | SER A 266ILE A 271ASP A 273ASP A 347 | NoneNCA A 900 (-4.6A)XYQ A1222 (-3.7A)None | 0.79A | 1yc5A-2hjhA:20.2 | 1yc5A-2hjhA:27.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iik | 3-KETOACYL-COATHIOLASE,PEROXISOMAL (Homo sapiens) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 4 | ALA A 129SER A 132ILE A 133ILE A 86 | None | 0.70A | 1yc5A-2iikA:undetectable | 1yc5A-2iikA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mjp | PYROPHOSPHATASE (Methanocaldococcusjannaschii) |
PF01725(Ham1p_like) | 4 | ALA A 150SER A 153ASN A 98ILE A 101 | None | 0.86A | 1yc5A-2mjpA:undetectable | 1yc5A-2mjpA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r5j | MAJOR CAPSID PROTEINL1 (Alphapapillomavirus9) |
PF00500(Late_protein_L1) | 4 | ALA A 345SER A 347ASN A 357ASP A 350 | None | 0.90A | 1yc5A-2r5jA:undetectable | 1yc5A-2r5jA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rkv | TRICHOTHECENE3-O-ACETYLTRANSFERASE (Fusariumgraminearum) |
PF02458(Transferase) | 4 | ALA A 95ILE A 144ASP A 92ILE A 116 | None | 1.00A | 1yc5A-2rkvA:undetectable | 1yc5A-2rkvA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uyk | PROTEIN TDCF (Escherichiacoli) |
PF01042(Ribonuc_L-PSP) | 4 | ALA A 50SER A 53ILE A 121ILE A 78 | None | 0.87A | 1yc5A-2uykA:undetectable | 1yc5A-2uykA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v15 | DNA PROTECTIONDURING STARVATIONPROTEIN (Streptococcussuis) |
PF00210(Ferritin) | 4 | ALA A 151SER A 154ILE A 155ILE A 69 | None | 0.71A | 1yc5A-2v15A:undetectable | 1yc5A-2v15A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xok | ATP SYNTHASE SUBUNITGAMMA, MITOCHONDRIAL (Saccharomycescerevisiae) |
PF00231(ATP-synt) | 4 | ALA G 215SER G 143ILE G 146ILE G 164 | None | 1.01A | 1yc5A-2xokG:undetectable | 1yc5A-2xokG:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yrl | KIAA1837 PROTEIN (Homo sapiens) |
PF00801(PKD) | 4 | ALA A 9SER A 32ILE A 37ASP A 79 | None | 0.98A | 1yc5A-2yrlA:undetectable | 1yc5A-2yrlA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3brz | TODX (Pseudomonasputida) |
PF03349(Toluene_X) | 4 | ALA A 237SER A 21ILE A 299ASP A 298 | None | 0.96A | 1yc5A-3brzA:undetectable | 1yc5A-3brzA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cpr | DIHYDRODIPICOLINATESYNTHETASE (Corynebacteriumglutamicum) |
PF00701(DHDPS) | 4 | ALA A 285SER A 263ILE A 283ASP A 278 | None | 0.95A | 1yc5A-3cprA:undetectable | 1yc5A-3cprA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3db2 | PUTATIVENADPH-DEPENDENTOXIDOREDUCTASE (Desulfitobacteriumhafniense) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | ALA A 323SER A 326ASP A 109ILE A 92 | None | 0.95A | 1yc5A-3db2A:3.1 | 1yc5A-3db2A:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddh | PUTATIVE HALOACIDDEHALOGENASE-LIKEFAMILY HYDROLASE (Bacteroidesthetaiotaomicron) |
PF13419(HAD_2) | 4 | SER A 68ILE A 67ASN A 54ILE A 57 | GOL A 235 ( 4.9A)NoneNoneNone | 0.84A | 1yc5A-3ddhA:5.1 | 1yc5A-3ddhA:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g14 | NITROREDUCTASEFAMILY PROTEIN (Clostridiumnovyi) |
PF00881(Nitroreductase) | 4 | ALA A 135ILE A 132ASP A 58ILE A 48 | None | 1.02A | 1yc5A-3g14A:undetectable | 1yc5A-3g14A:23.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g68 | PUTATIVEPHOSPHOSUGARISOMERASE (Clostridioidesdifficile) |
PF01380(SIS) | 4 | SER A 113ILE A 129ASP A 127ASP A 123 | None | 1.01A | 1yc5A-3g68A:4.4 | 1yc5A-3g68A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gwj | ARYLPHORIN (Antheraeapernyi) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 4 | ILE A 201ASN A 157ILE A 158ASP A 159 | None | 0.87A | 1yc5A-3gwjA:undetectable | 1yc5A-3gwjA:16.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hgo | 12-OXOPHYTODIENOATEREDUCTASE 3 (Solanumlycopersicum) |
PF00724(Oxidored_FMN) | 4 | SER A 134ILE A 133ILE A 200ASP A 246 | None | 1.02A | 1yc5A-3hgoA:undetectable | 1yc5A-3hgoA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iuo | ATP-DEPENDENT DNAHELICASE RECQ (Porphyromonasgingivalis) |
no annotation | 4 | ALA A 637ILE A 641ASP A 639ILE A 668 | None | 0.91A | 1yc5A-3iuoA:undetectable | 1yc5A-3iuoA:22.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3jr3 | NAD-DEPENDENTDEACETYLASE (Thermotogamaritima) |
PF02146(SIR2) | 7 | ALA A 22SER A 25ILE A 30ASP A 32ASN A 99ILE A 100ASP A 101 | None | 0.25A | 1yc5A-3jr3A:40.5 | 1yc5A-3jr3A:99.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3js6 | UNCHARACTERIZED PARMPROTEIN (Staphylococcusaureus) |
no annotation | 4 | SER A 187ILE A 294ASP A 292ILE A 288 | None | 0.96A | 1yc5A-3js6A:undetectable | 1yc5A-3js6A:22.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3jwp | TRANSCRIPTIONALREGULATORY PROTEINSIR2 HOMOLOGUE (Plasmodiumfalciparum) |
PF02146(SIR2) | 4 | SER A 32ILE A 37ASN A 107ASP A 109 | None | 0.37A | 1yc5A-3jwpA:19.9 | 1yc5A-3jwpA:31.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ll9 | ISOPENTENYLPHOSPHATE KINASE (Methanothermobacterthermautotrophicus) |
PF00696(AA_kinase) | 4 | ALA A 243ASN A 25ILE A 11ASP A 22 | None | 0.78A | 1yc5A-3ll9A:3.6 | 1yc5A-3ll9A:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pkj | NAD-DEPENDENTDEACETYLASESIRTUIN-6 (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 51SER A 54ILE A 59ASN A 112ASP A 114 | A2N A1000 (-3.5A)NoneNoneNoneNone | 0.43A | 1yc5A-3pkjA:24.7 | 1yc5A-3pkjA:27.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pkj | NAD-DEPENDENTDEACETYLASESIRTUIN-6 (Homo sapiens) |
PF02146(SIR2) | 4 | SER A 54ILE A 59ASP A 61ASP A 114 | NoneNoneA2N A1000 (-4.0A)None | 0.82A | 1yc5A-3pkjA:24.7 | 1yc5A-3pkjA:27.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rb5 | NA/CA EXCHANGEPROTEIN (Drosophilamelanogaster) |
PF03160(Calx-beta) | 4 | ALA A 474ILE A 442ILE A 470ASP A 469 | None | 0.93A | 1yc5A-3rb5A:undetectable | 1yc5A-3rb5A:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rhd | LACTALDEHYDEDEHYDROGENASE (Methanocaldococcusjannaschii) |
PF00171(Aldedh) | 4 | SER A 286ILE A 287ASP A 289ASP A 284 | None | 1.00A | 1yc5A-3rhdA:3.8 | 1yc5A-3rhdA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rpl | D-FRUCTOSE1,6-BISPHOSPHATASECLASS2/SEDOHEPTULOSE1,7-BISPHOSPHATASE (Synechocystissp. PCC 6803) |
PF03320(FBPase_glpX) | 4 | ALA A 204SER A 206ILE A 214ILE A 196 | None | 0.87A | 1yc5A-3rplA:undetectable | 1yc5A-3rplA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wyz | RIBONUCLEASE PPROTEIN COMPONENT 3 (Thermococcuskodakarensis) |
PF01876(RNase_P_p30) | 4 | ALA A 205SER A 208ILE A 175ILE A 198 | None | 0.76A | 1yc5A-3wyzA:undetectable | 1yc5A-3wyzA:20.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zg6 | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-6 (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 51SER A 54ILE A 59ASN A 112ASP A 114 | APR A1296 (-3.7A)NoneNoneNoneNone | 0.36A | 1yc5A-3zg6A:23.7 | 1yc5A-3zg6A:34.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zg6 | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-6 (Homo sapiens) |
PF02146(SIR2) | 4 | SER A 54ILE A 59ASP A 61ASP A 114 | NoneNoneGOL A1299 ( 3.1A)None | 0.81A | 1yc5A-3zg6A:23.7 | 1yc5A-3zg6A:34.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4az7 | BETA-N-ACETYLHEXOSAMINIDASE (Streptococcuspneumoniae) |
PF00728(Glyco_hydro_20) | 4 | ALA A 245SER A 236ASP A 248ASP A 234 | None | 0.90A | 1yc5A-4az7A:undetectable | 1yc5A-4az7A:19.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4bn5 | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-3,MITOCHONDRIAL (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 146SER A 149ASN A 229ILE A 230ASP A 231 | CNA A1395 (-3.1A)CNA A1395 (-4.3A)CNA A1395 (-3.7A)SR7 A1396 (-4.8A)CNA A1395 (-3.5A) | 0.37A | 1yc5A-4bn5A:24.6 | 1yc5A-4bn5A:36.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4bn5 | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-3,MITOCHONDRIAL (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 146SER A 149ILE A 154ASN A 229ASP A 231 | CNA A1395 (-3.1A)CNA A1395 (-4.3A)CNA A1395 (-3.8A)CNA A1395 (-3.7A)CNA A1395 (-3.5A) | 0.39A | 1yc5A-4bn5A:24.6 | 1yc5A-4bn5A:36.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cn8 | PROXIMAL THREADMATRIX PROTEIN 1 (Mytilusgalloprovincialis) |
PF00092(VWA) | 4 | SER A 62ILE A 65ILE A 201ASP A 173 | None | 0.97A | 1yc5A-4cn8A:5.2 | 1yc5A-4cn8A:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f1k | THROMBOSPONDINRELATED ANONYMOUSPROTEIN (Plasmodiumfalciparum) |
PF00092(VWA) | 4 | SER A 56ILE A 59ILE A 190ASP A 162 | None | 1.00A | 1yc5A-4f1kA:4.5 | 1yc5A-4f1kA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fx5 | VON WILLEBRANDFACTOR TYPE A (Catenulisporaacidiphila) |
PF13768(VWA_3) | 4 | ALA A 132ASP A 67ILE A 60ASP A 61 | NoneNoneNone NA A 501 ( 3.8A) | 0.95A | 1yc5A-4fx5A:4.8 | 1yc5A-4fx5A:21.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g1c | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 59SER A 62ASN A 141ILE A 142ASP A 143 | CNA A 402 (-3.0A)CNA A 402 ( 4.1A)CNA A 402 (-4.1A)CNA A 402 (-4.7A)CNA A 402 (-3.7A) | 0.27A | 1yc5A-4g1cA:24.9 | 1yc5A-4g1cA:30.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gek | TRNA(CMO5U34)-METHYLTRANSFERASE (Escherichiacoli) |
PF13649(Methyltransf_25) | 4 | ALA A 70SER A 73ASP A 62ILE A 42 | GEK A 302 ( 4.1A)NoneGEK A 302 ( 4.5A)None | 0.93A | 1yc5A-4gekA:2.8 | 1yc5A-4gekA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gk9 | AGGLUTININ (BOA) (Burkholderiaoklahomensis) |
no annotation | 4 | ALA A 43ILE A 113ASN A 45ILE A 46 | None | 0.92A | 1yc5A-4gk9A:undetectable | 1yc5A-4gk9A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6m | ACTIN-LIKE PROTEINARP9 (Saccharomycescerevisiae) |
PF00022(Actin) | 4 | ILE B 73ASP B 75ILE B 126ASP B 123 | None | 0.90A | 1yc5A-4i6mB:undetectable | 1yc5A-4i6mB:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iao | NAD-DEPENDENTHISTONE DEACETYLASESIR2 (Saccharomycescerevisiae) |
PF02146(SIR2)PF04574(DUF592) | 6 | ALA A 263SER A 266ILE A 271ASN A 345ILE A 346ASP A 347 | APR A 602 (-3.3A)NoneNoneNoneNoneNone | 0.48A | 1yc5A-4iaoA:20.9 | 1yc5A-4iaoA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iao | NAD-DEPENDENTHISTONE DEACETYLASESIR2 (Saccharomycescerevisiae) |
PF02146(SIR2)PF04574(DUF592) | 4 | SER A 266ILE A 271ASP A 273ASP A 347 | NoneNoneAPR A 602 (-3.9A)None | 0.84A | 1yc5A-4iaoA:20.9 | 1yc5A-4iaoA:21.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ig9 | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 262SER A 265ASN A 346ILE A 347ASP A 348 | None | 0.27A | 1yc5A-4ig9A:21.8 | 1yc5A-4ig9A:34.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ig9 | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 5 | SER A 265ILE A 270ASN A 346ILE A 347ASP A 348 | None | 0.62A | 1yc5A-4ig9A:21.8 | 1yc5A-4ig9A:34.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igl | YENBYENC2 (Yersiniaentomophaga;Yersiniaentomophaga) |
PF03534(SpvB)PF12255(TcdB_toxin_midC)PF12256(TcdB_toxin_midN)no annotation | 4 | ILE A1088ASN B 77ILE B 79ASP B 73 | None | 1.00A | 1yc5A-4iglA:undetectable | 1yc5A-4iglA:10.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ihq | FLAI ATPASE (Sulfolobusacidocaldarius) |
PF00437(T2SSE) | 4 | ALA A 77SER A 79ILE A 80ILE A 96 | None | 0.91A | 1yc5A-4ihqA:2.6 | 1yc5A-4ihqA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ivf | PUTATIVEUNCHARACTERIZEDPROTEIN (Lodderomyceselongisporus) |
PF00043(GST_C)PF02798(GST_N) | 4 | ILE A 8ASP A 31ASN A 65ASP A 63 | None | 0.98A | 1yc5A-4ivfA:undetectable | 1yc5A-4ivfA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iwn | TRNA(CMO5U34)-METHYLTRANSFERASE (Escherichiacoli) |
PF13649(Methyltransf_25) | 4 | ALA A 70SER A 73ASP A 62ILE A 42 | GEK A 301 ( 4.1A)NoneGEK A 301 ( 4.5A)None | 0.88A | 1yc5A-4iwnA:2.9 | 1yc5A-4iwnA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nbq | POLYRIBONUCLEOTIDENUCLEOTIDYLTRANSFERASE (Coxiellaburnetii) |
PF00013(KH_1)PF00575(S1)PF01138(RNase_PH)PF03725(RNase_PH_C)PF03726(PNPase) | 4 | ALA A 589ILE A 600ASP A 591ILE A 582 | None | 0.99A | 1yc5A-4nbqA:undetectable | 1yc5A-4nbqA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o5f | TYPE IIIPANTOTHENATE KINASE (Burkholderiathailandensis) |
PF03309(Pan_kinase) | 4 | ALA A 60ILE A 15ASN A 54ILE A 52 | None | 0.96A | 1yc5A-4o5fA:undetectable | 1yc5A-4o5fA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9x | TCDB2, TCCC3 (Photorhabdusluminescens) |
PF03534(SpvB)PF12255(TcdB_toxin_midC)PF12256(TcdB_toxin_midN) | 4 | ALA A1958SER A1942ASP A1956ASP A1961 | None | 0.85A | 1yc5A-4o9xA:undetectable | 1yc5A-4o9xA:8.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4okr | MICRONEMAL PROTEINMIC2 (Toxoplasmagondii) |
PF00090(TSP_1)PF00092(VWA) | 4 | SER A 84ILE A 87ILE A 81ASP A 82 | None | 0.99A | 1yc5A-4okrA:3.8 | 1yc5A-4okrA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oku | MICRONEMAL PROTEINMIC2 (Toxoplasmagondii) |
PF00090(TSP_1)PF00092(VWA) | 4 | SER A 84ILE A 87ILE A 81ASP A 82 | None | 1.00A | 1yc5A-4okuA:3.7 | 1yc5A-4okuA:22.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4twi | NAD-DEPENDENTPROTEIN DEACYLASE 1 (Archaeoglobusfulgidus) |
PF02146(SIR2) | 5 | ALA A 21SER A 24ILE A 29ASN A 99ASP A 101 | None | 0.49A | 1yc5A-4twiA:27.9 | 1yc5A-4twiA:40.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wd9 | NISIN BIOSYNTHESISPROTEIN NISB (Lactococcuslactis) |
PF04738(Lant_dehydr_N)PF14028(Lant_dehydr_C) | 4 | SER A 552ASN A 535ILE A 536ASP A 550 | None | 0.89A | 1yc5A-4wd9A:undetectable | 1yc5A-4wd9A:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8i | LYSYL AMINOPEPTIDASE (Pyrococcusfuriosus) |
PF05343(Peptidase_M42) | 4 | ALA A 214ASN A 46ILE A 48ASP A 42 | None | 0.99A | 1yc5A-4x8iA:undetectable | 1yc5A-4x8iA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xri | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 4 | ALA A 472SER A 474ILE A 427ASP A 431 | None | 0.85A | 1yc5A-4xriA:undetectable | 1yc5A-4xriA:15.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4y6o | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 7 | ALA A 85SER A 88ILE A 93ASP A 95ASN A 168ILE A 169ASP A 170 | None | 0.38A | 1yc5A-4y6oA:10.7 | 1yc5A-4y6oA:34.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypj | BETA GALACTOSIDASE (Bacilluscirculans) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 4 | ALA A 401SER A 443ILE A 444ILE A 448 | None | 0.87A | 1yc5A-4ypjA:undetectable | 1yc5A-4ypjA:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zzh | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 262SER A 265ASN A 346ILE A 347ASP A 348 | None | 0.27A | 1yc5A-4zzhA:20.9 | 1yc5A-4zzhA:28.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zzh | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 5 | SER A 265ILE A 270ASN A 346ILE A 347ASP A 348 | None | 0.53A | 1yc5A-4zzhA:20.9 | 1yc5A-4zzhA:28.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a22 | VESICULAR STOMATITISVIRUS L POLYMERASE (Vesicularstomatitisvirus) |
PF00946(Mononeg_RNA_pol)PF14314(Methyltrans_Mon)PF14318(Mononeg_mRNAcap) | 4 | SER A1771ILE A1774ASN A1807ILE A1811 | None | 0.89A | 1yc5A-5a22A:2.6 | 1yc5A-5a22A:8.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a3c | SIR2 FAMILY PROTEIN (Streptococcuspyogenes) |
no annotation | 4 | ALA A 34SER A 37ASN A 118ASP A 120 | NAD A1294 (-3.3A)NAD A1294 ( 4.1A)NAD A1294 (-3.9A)NAD A1294 (-3.9A) | 0.31A | 1yc5A-5a3cA:13.1 | 1yc5A-5a3cA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5btr | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 6 | ALA A 262SER A 265ILE A 270ASN A 346ILE A 347ASP A 348 | None | 0.29A | 1yc5A-5btrA:20.7 | 1yc5A-5btrA:29.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5chc | DMSO REDUCTASEFAMILY TYPE IIENZYME,MOLYBDOPTERINSUBUNIT (Azospira oryzae) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | ALA A 753ILE A 501ILE A 505ASP A 504 | None | 0.99A | 1yc5A-5chcA:3.8 | 1yc5A-5chcA:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fei | DISTAL TUBE PROTEIN (Bacillus virusphi29) |
PF16838(Caud_tail_N) | 4 | ASP A 311ASN A 354ILE A 352ASP A 377 | None | 0.64A | 1yc5A-5feiA:undetectable | 1yc5A-5feiA:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fq6 | PUTATIVE LIPOPROTEIN (Bacteroidesthetaiotaomicron) |
PF12771(SusD-like_2) | 4 | SER A 310ILE A 311ILE A 307ASP A 308 | None | 1.01A | 1yc5A-5fq6A:undetectable | 1yc5A-5fq6A:18.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fyq | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 7 | ALA A 85SER A 88ILE A 93ASP A 95ASN A 168ILE A 169ASP A 170 | SO4 A1357 ( 4.1A)NoneNoneSO4 A1357 ( 4.8A)NoneNoneNone | 0.25A | 1yc5A-5fyqA:22.0 | 1yc5A-5fyqA:30.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j7r | PUTATIVE LIPOPROTEIN (Clostridiumperfringens) |
PF10646(Germane) | 4 | SER A 146ILE A 144ILE A 42ASP A 72 | None | 0.85A | 1yc5A-5j7rA:undetectable | 1yc5A-5j7rA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oj7 | NAD-DEPENDENTPROTEIN DEACYLASE (Xenopustropicalis) |
no annotation | 5 | ALA A 62SER A 65ILE A 70ASN A 143ASP A 145 | AR6 A 401 (-3.6A)NoneNoneNoneNone | 0.30A | 1yc5A-5oj7A:8.9 | 1yc5A-5oj7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oj7 | NAD-DEPENDENTPROTEIN DEACYLASE (Xenopustropicalis) |
no annotation | 5 | SER A 65ILE A 70ASP A 72ASN A 143ASP A 145 | NoneNoneAR6 A 401 (-3.7A)NoneNone | 0.76A | 1yc5A-5oj7A:8.9 | 1yc5A-5oj7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oji | DEHYDROGENASE/REDUCTASE SDR FAMILYMEMBER 4 (Caenorhabditiselegans) |
no annotation | 4 | ALA A 231ILE A 22ASP A 228ILE A 252 | NoneNAP A 301 (-3.5A)NoneNone | 1.02A | 1yc5A-5ojiA:4.1 | 1yc5A-5ojiA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ol0 | PUTATIVE SILENTINFORMATIONREGULATOR 2,PUTATIVESILENT INFORMATIONREGULATOR 2 (Leishmaniainfantum) |
no annotation | 6 | ALA A 40SER A 43ILE A 48ASN A 125ILE A 126ASP A 127 | None | 0.28A | 1yc5A-5ol0A:9.4 | 1yc5A-5ol0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v8f | DNA REPLICATIONLICENSING FACTORMCM7 (Saccharomycescerevisiae) |
PF00493(MCM)PF14551(MCM_N)PF17207(MCM_OB) | 4 | ALA 7 567ASP 7 527ILE 7 523ASP 7 524 | None | 0.99A | 1yc5A-5v8f7:undetectable | 1yc5A-5v8f7:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vj2 | NON-STRUCTURALPROTEIN 1 (Respiratorysyncytial virus) |
PF03438(Pneumo_NS1) | 4 | ALA A 40SER A 63ILE A 65ILE A 35 | None CL A 205 (-2.9A)NoneNone | 0.92A | 1yc5A-5vj2A:undetectable | 1yc5A-5vj2A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7a | ACYLOXYACYLHYDROLASE LARGESUBUNIT (Oryctolaguscuniculus) |
no annotation | 4 | ALA B 265SER B 301ASP B 296ASN B 335 | None | 0.74A | 1yc5A-5w7aB:undetectable | 1yc5A-5w7aB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wtk | CRISPR-ASSOCIATEDENDORIBONUCLEASEC2C2 (Leptotrichiashahii) |
no annotation | 4 | SER A 841ILE A 877ASN A 622ILE A 623 | None | 0.95A | 1yc5A-5wtkA:undetectable | 1yc5A-5wtkA:10.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x49 | PROBABLE XAA-PROAMINOPEPTIDASE 3 (Homo sapiens) |
PF00557(Peptidase_M24)PF05195(AMP_N) | 4 | SER A 489ILE A 487ILE A 450ASP A 476 | None | 0.94A | 1yc5A-5x49A:undetectable | 1yc5A-5x49A:20.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6enx | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Danio rerio) |
no annotation | 5 | ALA A 55SER A 58ASN A 137ILE A 138ASP A 139 | BJW A 303 (-3.5A)NoneNoneBJW A 303 (-3.9A)None | 0.32A | 1yc5A-6enxA:24.0 | 1yc5A-6enxA:32.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gmb | HYDROXYACID OXIDASE1 (Homo sapiens) |
no annotation | 4 | SER A 216ILE A 217ILE A 213ASP A 214 | None | 0.99A | 1yc5A-6gmbA:undetectable | 1yc5A-6gmbA:undetectable |