SIMILAR PATTERNS OF AMINO ACIDS FOR 1YC2_D_NCAD510_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1avb | ARCELIN-1 (Phaseolusvulgaris) |
PF00139(Lectin_legB) | 4 | PHE A 225ASN A 55ILE A 54ASP A 194 | None | 1.17A | 1yc2D-1avbA:undetectable | 1yc2D-1avbA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d3y | DNA TOPOISOMERASE VIA SUBUNIT (Methanocaldococcusjannaschii) |
PF04406(TP6A_N) | 4 | ALA A 118PHE A 113ASN A 121ILE A 123 | NA A 370 ( 3.7A)NoneNoneNone | 1.15A | 1yc2D-1d3yA:2.1 | 1yc2D-1d3yA:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dgj | ALDEHYDEOXIDOREDUCTASE (Desulfovibriodesulfuricans) |
PF00111(Fer2)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2) | 4 | ALA A 877PHE A 544ASN A 881ASP A 551 | None | 1.06A | 1yc2D-1dgjA:undetectable | 1yc2D-1dgjA:14.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eke | RIBONUCLEASE HII (Methanocaldococcusjannaschii) |
PF01351(RNase_HII) | 4 | ALA A 113PHE A 121ILE A 6ASP A 7 | None | 1.02A | 1yc2D-1ekeA:undetectable | 1yc2D-1ekeA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1foh | PHENOL HYDROXYLASE (Cutaneotrichosporoncutaneum) |
PF01494(FAD_binding_3)PF07976(Phe_hydrox_dim) | 4 | ALA A 366PHE A 418ILE A 83ASP A 102 | None | 0.88A | 1yc2D-1fohA:2.4 | 1yc2D-1fohA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gdh | D-GLYCERATEDEHYDROGENASE (Hyphomicrobiummethylovorum) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | ALA A 19ASN A 304ILE A 307ASP A 308 | None | 1.13A | 1yc2D-1gdhA:3.4 | 1yc2D-1gdhA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i1q | ANTHRANILATESYNTHASE COMPONENTII (Salmonellaenterica) |
PF00117(GATase) | 4 | ALA B 155PHE B 166ASN B 146ASP B 114 | None | 1.13A | 1yc2D-1i1qB:3.3 | 1yc2D-1i1qB:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i7q | TRPG (Serratiamarcescens) |
PF00117(GATase) | 4 | ALA B 158PHE B 169ASN B 149ASP B 116 | None | 1.14A | 1yc2D-1i7qB:4.3 | 1yc2D-1i7qB:22.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q14 | HST2 PROTEIN (Saccharomycescerevisiae) |
PF02146(SIR2) | 4 | ALA A 33ASN A 116ILE A 117ASP A 118 | None | 0.24A | 1yc2D-1q14A:19.0 | 1yc2D-1q14A:30.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q1a | HST2 PROTEIN (Saccharomycescerevisiae) |
PF02146(SIR2) | 5 | ALA A 33PHE A 44ASN A 116ILE A 117ASP A 118 | OAD A1001 (-3.9A)OAD A1001 (-3.5A)NoneOAD A1001 ( 4.4A)None | 0.60A | 1yc2D-1q1aA:20.1 | 1yc2D-1q1aA:33.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5m | PROSTAGLANDIN-E29-REDUCTASE (Oryctolaguscuniculus) |
PF00248(Aldo_ket_red) | 4 | ALA A 137PHE A 139ILE A 312ASP A 309 | None | 0.93A | 1yc2D-1q5mA:undetectable | 1yc2D-1q5mA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qnr | ENDO-1,4-B-D-MANNANASE (Trichodermareesei) |
PF00150(Cellulase) | 4 | ALA A 163PHE A 162ILE A 7ASP A 236 | None | 1.13A | 1yc2D-1qnrA:undetectable | 1yc2D-1qnrA:20.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1s5p | NAD-DEPENDENTDEACETYLASE (Escherichiacoli) |
PF02146(SIR2) | 4 | ALA A 49ASN A 130ILE A 131ASP A 132 | None | 0.39A | 1yc2D-1s5pA:21.6 | 1yc2D-1s5pA:39.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1s7g | NAD-DEPENDENTDEACETYLASE 2 (Archaeoglobusfulgidus) |
PF02146(SIR2) | 4 | ALA A 24ASN A 101ILE A 102ASP A 103 | NAD A 703 (-3.8A)NoneNoneNone | 0.17A | 1yc2D-1s7gA:40.2 | 1yc2D-1s7gA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tki | TITIN (Homo sapiens) |
PF00069(Pkinase) | 4 | ALA A 168PHE A 165ILE A 145ASP A 202 | None | 1.02A | 1yc2D-1tkiA:undetectable | 1yc2D-1tkiA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhe | AEROBIC RESPIRATIONCONTROL PROTEIN ARCA (Escherichiacoli) |
PF00072(Response_reg) | 4 | ALA A 114PHE A 23ILE A 101ASP A 99 | None | 1.17A | 1yc2D-1xheA:5.4 | 1yc2D-1xheA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y0y | FRV OPERON PROTEINFRVX (Pyrococcushorikoshii) |
PF05343(Peptidase_M42) | 4 | ALA A 219ASN A 51ILE A 53ASP A 47 | None | 0.98A | 1yc2D-1y0yA:undetectable | 1yc2D-1y0yA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2akk | PHNA-LIKE PROTEIN (Rhodopseudomonaspalustris) |
PF03831(PhnA) | 4 | ALA A 72ASN A 18ILE A 43ASP A 17 | None | 1.13A | 1yc2D-2akkA:undetectable | 1yc2D-2akkA:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2atc | ASPARTATECARBAMOYLTRANSFERASE, CATALYTIC CHAIN (Escherichiacoli) |
PF00185(OTCace)PF02729(OTCace_N) | 4 | ALA A 127PHE A 59ASN A 126ILE A 9 | None | 1.07A | 1yc2D-2atcA:4.3 | 1yc2D-2atcA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cit | ENDOGLUCANASE H (Ruminiclostridiumthermocellum) |
PF02156(Glyco_hydro_26) | 4 | ALA A 147PHE A 142ASN A 149ILE A 102 | None | 1.17A | 1yc2D-2citA:undetectable | 1yc2D-2citA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0o | DIOLDEHYDRATASE-REACTIVATING FACTOR LARGESUBUNIT (Klebsiellaoxytoca) |
PF08841(DDR) | 4 | ALA A 76ASN A 74ILE A 7ASP A 8 | NoneNoneNone MG A1003 ( 4.1A) | 1.18A | 1yc2D-2d0oA:undetectable | 1yc2D-2d0oA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dfe | RIBONUCLEASE HII (Thermococcuskodakarensis) |
PF01351(RNase_HII) | 4 | ALA A 106PHE A 114ILE A 6ASP A 7 | None | 1.02A | 1yc2D-2dfeA:undetectable | 1yc2D-2dfeA:24.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fea | 2-HYDROXY-3-KETO-5-METHYLTHIOPENTENYL-1-PHOSPHATEPHOSPHATASE (Bacillussubtilis) |
PF12710(HAD) | 4 | PHE A 104ASN A 21ILE A 22ASP A 13 | NoneEDO A1305 (-3.4A)EDO A1306 ( 3.8A)None | 1.11A | 1yc2D-2feaA:5.4 | 1yc2D-2feaA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hgs | PROTEIN (GLUTATHIONESYNTHETASE) (Homo sapiens) |
PF03199(GSH_synthase)PF03917(GSH_synth_ATP) | 4 | ALA A 150ASN A 146ILE A 145ASP A 127 | GSH A 503 (-4.8A) MG A 501 ( 2.7A)NoneSO4 A 505 ( 4.8A) | 1.18A | 1yc2D-2hgsA:undetectable | 1yc2D-2hgsA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hjh | NAD-DEPENDENTHISTONE DEACETYLASESIR2 (Saccharomycescerevisiae) |
PF02146(SIR2)PF04574(DUF592) | 5 | ALA A 263PHE A 274ASN A 345ILE A 346ASP A 347 | XYQ A1222 (-3.4A)NCA A 900 ( 3.9A)NoneNCA A 900 (-4.6A)None | 0.56A | 1yc2D-2hjhA:19.3 | 1yc2D-2hjhA:25.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k4v | UNCHARACTERIZEDPROTEIN PA1076 (Pseudomonasaeruginosa) |
PF16703(DUF5064) | 4 | PHE A 54ASN A 24ILE A 23ASP A 22 | None | 0.93A | 1yc2D-2k4vA:undetectable | 1yc2D-2k4vA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p2v | ALPHA-2,3-SIALYLTRANSFERASE (Campylobacterjejuni) |
PF06002(CST-I) | 4 | ALA A 181PHE A 196ILE A 258ASP A 257 | NoneCSF A1001 (-3.5A)NoneNone | 1.14A | 1yc2D-2p2vA:undetectable | 1yc2D-2p2vA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q27 | OXALYL-COADECARBOXYLASE (Escherichiacoli) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | ALA A 500ASN A 473ILE A 471ASP A 447 | NoneNoneNone MG A1001 ( 2.8A) | 0.98A | 1yc2D-2q27A:13.8 | 1yc2D-2q27A:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qe7 | ATP SYNTHASE SUBUNITBETA (Bacillus sp.TA2.A1) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N) | 4 | ALA D 75ASN D 28ILE D 30ASP D 72 | None | 1.12A | 1yc2D-2qe7D:undetectable | 1yc2D-2qe7D:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qpq | PROTEIN BUG27 (Bordetellapertussis) |
PF03401(TctC) | 4 | ALA A 100ASN A 98ILE A 97ASP A 273 | None | 1.00A | 1yc2D-2qpqA:undetectable | 1yc2D-2qpqA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2tdd | THYMIDYLATE SYNTHASE (Lactobacilluscasei) |
PF00303(Thymidylat_synt) | 4 | ALA A 220PHE A 255ASN A 229ILE A 230 | NoneNoneUFP A 529 (-3.7A)None | 1.00A | 1yc2D-2tddA:undetectable | 1yc2D-2tddA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsi | FAD SYNTHETASE (Saccharomycescerevisiae) |
PF01507(PAPS_reduct) | 4 | ALA A 33ASN A 201ILE A 202ASP A 198 | None | 1.09A | 1yc2D-2wsiA:2.4 | 1yc2D-2wsiA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wyr | COBALT-ACTIVATEDPEPTIDASE TET1 (Pyrococcushorikoshii) |
PF05343(Peptidase_M42) | 4 | ALA A 211ASN A 44ILE A 46ASP A 40 | None | 0.92A | 1yc2D-2wyrA:undetectable | 1yc2D-2wyrA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsi | PROBABLE GIBBERELLINRECEPTOR GID1L1 (Arabidopsisthaliana) |
PF07859(Abhydrolase_3) | 4 | ALA A 262PHE A 251ASN A 199ILE A 196 | None | 0.88A | 1yc2D-2zsiA:2.2 | 1yc2D-2zsiA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3asp | CAPSID PROTEIN (Norwalk virus) |
PF00915(Calici_coat)PF08435(Calici_coat_C) | 4 | ALA A 444ASN A 440ILE A 398ASP A 397 | None | 1.14A | 1yc2D-3aspA:undetectable | 1yc2D-3aspA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b13 | DEDICATOR OFCYTOKINESIS PROTEIN2 (Homo sapiens) |
PF06920(DHR-2) | 4 | ALA A1549PHE A1550ASN A1457ASP A1454 | None | 1.17A | 1yc2D-3b13A:undetectable | 1yc2D-3b13A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c6a | TERMINASE LARGESUBUNIT (Escherichiavirus RB49) |
PF17289(Terminase_6C) | 4 | ALA A 560PHE A 556ILE A 413ASP A 414 | None | 1.11A | 1yc2D-3c6aA:undetectable | 1yc2D-3c6aA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3co8 | ALANINE RACEMASE (Oenococcus oeni) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 4 | PHE A 164ASN A 134ILE A 136ASP A 130 | None | 0.99A | 1yc2D-3co8A:undetectable | 1yc2D-3co8A:24.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ecq | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Streptococcuspneumoniae) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 4 | ALA A 580ASN A 579ILE A 591ASP A 588 | None CA A2000 (-2.8A)None CA A2000 (-2.3A) | 0.99A | 1yc2D-3ecqA:undetectable | 1yc2D-3ecqA:9.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fah | ALDEHYDEOXIDOREDUCTASE (Desulfovibriogigas) |
PF00111(Fer2)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2) | 4 | ALA A 877PHE A 542ASN A 881ASP A 549 | None | 1.11A | 1yc2D-3fahA:undetectable | 1yc2D-3fahA:14.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gb0 | PEPTIDASE T (Bacillus cereus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | ALA A 147ASN A 57ILE A 59ASP A 45 | None | 0.97A | 1yc2D-3gb0A:undetectable | 1yc2D-3gb0A:24.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3jr3 | NAD-DEPENDENTDEACETYLASE (Thermotogamaritima) |
PF02146(SIR2) | 4 | ALA A 22ASN A 99ILE A 100ASP A 101 | None | 0.19A | 1yc2D-3jr3A:26.7 | 1yc2D-3jr3A:42.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l3b | ES1 FAMILY PROTEIN (Ehrlichiachaffeensis) |
PF01965(DJ-1_PfpI) | 4 | ALA A 151ASN A 186ILE A 188ASP A 183 | None | 0.98A | 1yc2D-3l3bA:5.6 | 1yc2D-3l3bA:25.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ll9 | ISOPENTENYLPHOSPHATE KINASE (Methanothermobacterthermautotrophicus) |
PF00696(AA_kinase) | 4 | ALA A 243ASN A 25ILE A 11ASP A 22 | None | 0.77A | 1yc2D-3ll9A:4.0 | 1yc2D-3ll9A:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oo9 | ABC TRANSPORTERBINDING PROTEIN ACBH (Actinoplanessp. SE50/110) |
PF01547(SBP_bac_1) | 4 | ALA A 229PHE A 171ASN A 230ASP A 381 | None | 1.09A | 1yc2D-3oo9A:undetectable | 1yc2D-3oo9A:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pjx | CYCLIC DIMERIC GMPBINDING PROTEIN (Pseudomonasfluorescens) |
PF00563(EAL)PF00990(GGDEF) | 4 | ALA A 358ASN A 394ILE A 362ASP A 342 | EDO A 5 (-3.3A)EDO A 5 (-3.5A)NoneNone | 1.07A | 1yc2D-3pjxA:undetectable | 1yc2D-3pjxA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pkj | NAD-DEPENDENTDEACETYLASESIRTUIN-6 (Homo sapiens) |
PF02146(SIR2) | 4 | ALA A 51PHE A 62ASN A 112ASP A 114 | A2N A1000 (-3.5A)A2N A1000 (-3.8A)NoneNone | 0.67A | 1yc2D-3pkjA:22.7 | 1yc2D-3pkjA:26.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s9j | MEMBER OF DUF4221FAMILY (Bacteroidesvulgatus) |
PF13970(DUF4221) | 4 | ALA A 161ASN A 160ILE A 295ASP A 229 | None | 1.10A | 1yc2D-3s9jA:undetectable | 1yc2D-3s9jA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uiw | GLUTAREDOXIN 2 (Danio rerio) |
PF00462(Glutaredoxin) | 4 | ALA A 43PHE A 47ILE A 91ASP A 96 | None | 1.16A | 1yc2D-3uiwA:undetectable | 1yc2D-3uiwA:22.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zg6 | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-6 (Homo sapiens) |
PF02146(SIR2) | 4 | ALA A 51PHE A 62ASN A 112ASP A 114 | APR A1296 (-3.7A)APR A1296 (-3.6A)NoneNone | 0.67A | 1yc2D-3zg6A:21.8 | 1yc2D-3zg6A:30.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aq1 | SBSB PROTEIN (Geobacillusstearothermophilus) |
no annotation | 4 | ALA C 737PHE C 845ILE C 814ASP C 808 | None | 1.13A | 1yc2D-4aq1C:undetectable | 1yc2D-4aq1C:13.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4bn5 | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-3,MITOCHONDRIAL (Homo sapiens) |
PF02146(SIR2) | 4 | ALA A 146ASN A 229ILE A 230ASP A 231 | CNA A1395 (-3.1A)CNA A1395 (-3.7A)SR7 A1396 (-4.8A)CNA A1395 (-3.5A) | 0.34A | 1yc2D-4bn5A:20.6 | 1yc2D-4bn5A:31.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bpx | DNA POLYMERASE ALPHACATALYTIC SUBUNIT,DNA PRIMASE LARGESUBUNIT (Homo sapiens) |
PF04104(DNA_primase_lrg) | 4 | ALA B 224ASN B 220ILE B 217ASP B 193 | None | 1.11A | 1yc2D-4bpxB:undetectable | 1yc2D-4bpxB:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dq1 | THYMIDYLATE SYNTHASE (Staphylococcusaureus) |
PF00303(Thymidylat_synt) | 4 | ALA A 223PHE A 258ASN A 232ILE A 233 | UMP A 501 (-4.2A)NoneUMP A 501 (-2.7A)None | 0.95A | 1yc2D-4dq1A:undetectable | 1yc2D-4dq1A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4euu | SERINE/THREONINE-PROTEIN KINASE TBK1 (Homo sapiens) |
PF00069(Pkinase) | 4 | ALA A 161PHE A 158ILE A 136ASP A 203 | None | 1.17A | 1yc2D-4euuA:undetectable | 1yc2D-4euuA:22.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g1c | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Homo sapiens) |
PF02146(SIR2) | 4 | ALA A 59ASN A 141ILE A 142ASP A 143 | CNA A 402 (-3.0A)CNA A 402 (-4.1A)CNA A 402 (-4.7A)CNA A 402 (-3.7A) | 0.38A | 1yc2D-4g1cA:25.2 | 1yc2D-4g1cA:39.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g1c | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Homo sapiens) |
PF02146(SIR2) | 4 | ALA A 59PHE A 70ILE A 142ASP A 143 | CNA A 402 (-3.0A)CNA A 402 (-3.2A)CNA A 402 (-4.7A)CNA A 402 (-3.7A) | 1.09A | 1yc2D-4g1cA:25.2 | 1yc2D-4g1cA:39.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h2h | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Salipigerbermudensis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ALA A 192PHE A 215ILE A 173ASP A 172 | None | 1.12A | 1yc2D-4h2hA:undetectable | 1yc2D-4h2hA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iao | NAD-DEPENDENTHISTONE DEACETYLASESIR2 (Saccharomycescerevisiae) |
PF02146(SIR2)PF04574(DUF592) | 5 | ALA A 263PHE A 274ASN A 345ILE A 346ASP A 347 | APR A 602 (-3.3A)APR A 602 (-3.5A)NoneNoneNone | 0.59A | 1yc2D-4iaoA:23.7 | 1yc2D-4iaoA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4idm | DELTA-1-PYRROLINE-5-CARBOXYLATEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF00171(Aldedh) | 4 | PHE A 406ASN A 364ILE A 359ASP A 361 | None | 1.13A | 1yc2D-4idmA:4.0 | 1yc2D-4idmA:18.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ig9 | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 4 | ALA A 262ASN A 346ILE A 347ASP A 348 | None | 0.34A | 1yc2D-4ig9A:24.1 | 1yc2D-4ig9A:32.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ip4 | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME-LIKE PROTEIN (Ruegeria sp.TM1040) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ALA A 34ASN A 58ILE A 62ASP A 11 | None | 0.96A | 1yc2D-4ip4A:undetectable | 1yc2D-4ip4A:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iv5 | ASPARTATECARBAMOYLTRANSFERASE, PUTATIVE (Trypanosomacruzi) |
PF00185(OTCace)PF02729(OTCace_N) | 4 | ALA A 134PHE A 69ASN A 133ILE A 15 | None | 1.14A | 1yc2D-4iv5A:4.6 | 1yc2D-4iv5A:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jgi | PUTATIVEUNCHARACTERIZEDPROTEIN (Desulfitobacteriumhafniense) |
PF02310(B12-binding)PF02607(B12-binding_2) | 4 | ALA A 73PHE A 42ASN A 20ASP A 24 | None | 1.00A | 1yc2D-4jgiA:5.2 | 1yc2D-4jgiA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l22 | PHOSPHORYLASE (Streptococcusmutans) |
PF00343(Phosphorylase) | 4 | ALA A 110PHE A 59ASN A 278ILE A 55 | None | 1.10A | 1yc2D-4l22A:4.9 | 1yc2D-4l22A:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mhp | GLUTAMINYL CYCLASE,PUTATIVE (Ixodesscapularis) |
PF04389(Peptidase_M28) | 4 | PHE A 302ASN A 110ILE A 112ASP A 95 | None | 1.17A | 1yc2D-4mhpA:undetectable | 1yc2D-4mhpA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mlc | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Desulfitobacteriumhafniense) |
PF13458(Peripla_BP_6) | 4 | ALA A 201PHE A 199ILE A 126ASP A 123 | None | 1.13A | 1yc2D-4mlcA:4.7 | 1yc2D-4mlcA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6y | AMINOPEPTIDASE (Thermotogamaritima) |
PF05343(Peptidase_M42) | 4 | ALA A 204ASN A 43ILE A 45ASP A 39 | None | 0.92A | 1yc2D-4p6yA:undetectable | 1yc2D-4p6yA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q62 | LEUCINE-RICHREPEAT-AND COILEDCOIL-CONTAININGPROTEIN (Legionellapneumophila) |
PF13855(LRR_8) | 4 | ALA A 22PHE A 19ASN A 28ILE A 59 | None | 1.17A | 1yc2D-4q62A:undetectable | 1yc2D-4q62A:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qiw | DNA-DIRECTED RNAPOLYMERASE (Thermococcuskodakarensis) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 4 | ALA B 745ASN B 743ILE B 742ASP B 911 | None | 1.14A | 1yc2D-4qiwB:undetectable | 1yc2D-4qiwB:12.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r12 | PUTATIVEUNCHARACTERIZEDPROTEIN (Dictyosteliumpurpureum) |
PF05450(Nicastrin) | 4 | ALA A 380PHE A 390ILE A 448ASP A 447 | None | 0.77A | 1yc2D-4r12A:undetectable | 1yc2D-4r12A:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqk | LECTIN 2 (Agrocybeaegerita) |
PF13517(VCBS) | 4 | ALA A 36ASN A 35ILE A 22ASP A 21 | None | 1.12A | 1yc2D-4tqkA:undetectable | 1yc2D-4tqkA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tv7 | HTH-TYPETRANSCRIPTIONALREGULATORY PROTEINGABR (Bacillussubtilis) |
PF00155(Aminotran_1_2)PF00392(GntR) | 4 | ALA A 269ASN A 303ILE A 276ASP A 299 | None | 0.89A | 1yc2D-4tv7A:3.5 | 1yc2D-4tv7A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tvc | DEXTRANSUCRASE (Leuconostocmesenteroides) |
PF02324(Glyco_hydro_70) | 4 | ALA A1802PHE A1816ILE A1809ASP A2073 | NoneNoneNoneTYI A2075 (-3.9A) | 1.15A | 1yc2D-4tvcA:undetectable | 1yc2D-4tvcA:11.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8i | LYSYL AMINOPEPTIDASE (Pyrococcusfuriosus) |
PF05343(Peptidase_M42) | 4 | ALA A 214ASN A 46ILE A 48ASP A 42 | None | 0.88A | 1yc2D-4x8iA:undetectable | 1yc2D-4x8iA:24.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4y6o | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 4 | ALA A 85ASN A 168ILE A 169ASP A 170 | None | 0.31A | 1yc2D-4y6oA:20.0 | 1yc2D-4y6oA:30.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y9t | ABC TRANSPORTER,SOLUTE BINDINGPROTEIN (Agrobacteriumvitis) |
PF13407(Peripla_BP_4) | 4 | ALA A 211ASN A 212ILE A 215ASP A 214 | None | 1.14A | 1yc2D-4y9tA:5.7 | 1yc2D-4y9tA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzt | CELLULOSE HYDROLASE (Bacilluslicheniformis) |
PF00150(Cellulase)PF03442(CBM_X2) | 4 | ALA A 419ASN A 333ILE A 335ASP A 285 | None | 1.16A | 1yc2D-4yztA:undetectable | 1yc2D-4yztA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zzh | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 4 | ALA A 262ASN A 346ILE A 347ASP A 348 | None | 0.35A | 1yc2D-4zzhA:23.6 | 1yc2D-4zzhA:27.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a3m | CEA1 (Komagataellapastoris) |
PF10528(GLEYA) | 4 | ALA A 207PHE A 89ASN A 202ASP A 137 | NoneNone CA A 500 (-3.0A)NAG A 501 ( 2.5A) | 1.14A | 1yc2D-5a3mA:undetectable | 1yc2D-5a3mA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a55 | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Streptococcuspneumoniae) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 4 | ALA A 580ASN A 579ILE A 591ASP A 588 | None CA A2419 (-3.0A)None CA A2419 (-2.2A) | 1.02A | 1yc2D-5a55A:undetectable | 1yc2D-5a55A:11.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5btr | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 4 | ALA A 262ASN A 346ILE A 347ASP A 348 | None | 0.34A | 1yc2D-5btrA:23.7 | 1yc2D-5btrA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5da0 | SULPHATE TRANSPORTER (Deinococcusgeothermalis) |
PF00916(Sulfate_transp)PF01740(STAS) | 4 | ALA A 476PHE A 445ILE A 438ASP A 439 | None | 1.04A | 1yc2D-5da0A:undetectable | 1yc2D-5da0A:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e78 | BIFUNCTIONALP-450/NADPH-P450REDUCTASE (Bacillusmegaterium) |
PF00067(p450) | 4 | ALA A 99ASN A 253ILE A 254ASP A 250 | None | 1.16A | 1yc2D-5e78A:undetectable | 1yc2D-5e78A:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fyq | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 85PHE A 96ASN A 168ILE A 169ASP A 170 | SO4 A1357 ( 4.1A)NoneNoneNoneNone | 1.03A | 1yc2D-5fyqA:20.1 | 1yc2D-5fyqA:26.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h7k | ELONGATION FACTOR 2 (Pyrococcushorikoshii) |
no annotation | 4 | ALA A 124PHE A 171ILE A 157ASP A 154 | NoneNoneNoneGDP A 501 (-2.8A) | 1.11A | 1yc2D-5h7kA:undetectable | 1yc2D-5h7kA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hg0 | PANTOTHENATESYNTHETASE (Francisellatularensis) |
PF02569(Pantoate_ligase) | 4 | ALA A 4ASN A 6ILE A 7ASP A 96 | None | 1.14A | 1yc2D-5hg0A:undetectable | 1yc2D-5hg0A:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mu7 | COATOMER SUBUNITBETA (Chaetomiumthermophilum) |
PF01602(Adaptin_N) | 4 | ALA A 204PHE A 193ILE A 230ASP A 233 | None | 1.11A | 1yc2D-5mu7A:undetectable | 1yc2D-5mu7A:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mw5 | PROTEIN JAGGED-2 (Homo sapiens) |
PF01414(DSL)PF07657(MNNL) | 4 | ALA A 205ASN A 173ILE A 172ASP A 176 | None | 1.18A | 1yc2D-5mw5A:undetectable | 1yc2D-5mw5A:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nsq | AMINOPEPTIDASE,PUTATIVE (Trypanosomabrucei) |
PF00883(Peptidase_M17) | 4 | ALA A 345ASN A 344ILE A 291ASP A 294 | NoneNoneNone MN A 602 (-2.3A) | 1.09A | 1yc2D-5nsqA:undetectable | 1yc2D-5nsqA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nth | PUTATIVEAMINOPEPTIDASE (Leishmaniamajor) |
PF00883(Peptidase_M17) | 4 | ALA A 363ASN A 362ILE A 301ASP A 304 | NoneNoneNone MN A 603 (-2.6A) | 1.04A | 1yc2D-5nthA:undetectable | 1yc2D-5nthA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ol0 | PUTATIVE SILENTINFORMATIONREGULATOR 2,PUTATIVESILENT INFORMATIONREGULATOR 2 (Leishmaniainfantum) |
no annotation | 4 | ALA A 40ASN A 125ILE A 126ASP A 127 | None | 0.26A | 1yc2D-5ol0A:23.3 | 1yc2D-5ol0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5olp | PECTATE LYASE (Bacteroidesthetaiotaomicron) |
no annotation | 4 | ALA A 272PHE A 266ILE A 226ASP A 252 | None | 1.12A | 1yc2D-5olpA:undetectable | 1yc2D-5olpA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7q | CONSENSUS ELONGATIONFACTOR (syntheticconstruct) |
no annotation | 4 | ALA A 53ASN A 64ILE A 63ASP A 87 | None | 1.14A | 1yc2D-5w7qA:3.8 | 1yc2D-5w7qA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7q | CONSENSUS ELONGATIONFACTOR (syntheticconstruct) |
no annotation | 4 | ALA A 97ASN A 14ILE A 15ASP A 100 | None | 1.18A | 1yc2D-5w7qA:3.8 | 1yc2D-5w7qA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x4r | S PROTEIN (Middle Eastrespiratorysyndrome-relatedcoronavirus) |
no annotation | 4 | ALA A 336PHE A 323ILE A 48ASP A 54 | None | 1.10A | 1yc2D-5x4rA:undetectable | 1yc2D-5x4rA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x59 | S PROTEIN (Middle Eastrespiratorysyndrome-relatedcoronavirus) |
PF01601(Corona_S2)PF09408(Spike_rec_bind) | 4 | ALA A 336PHE A 323ILE A 48ASP A 54 | None | 1.09A | 1yc2D-5x59A:undetectable | 1yc2D-5x59A:10.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y09 | PROTEASE DO-LIKE 9 (Arabidopsisthaliana) |
no annotation | 4 | ALA A 293ASN A 167ILE A 201ASP A 200 | None | 1.03A | 1yc2D-5y09A:undetectable | 1yc2D-5y09A:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6auj | THYMIDYLATE SYNTHASE (Elizabethkingiaanophelis) |
PF00303(Thymidylat_synt) | 4 | ALA A 176PHE A 211ASN A 185ILE A 186 | NoneNonePGE A 301 ( 4.9A)None | 0.92A | 1yc2D-6aujA:undetectable | 1yc2D-6aujA:22.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6enx | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Danio rerio) |
no annotation | 5 | ALA A 55PHE A 66ASN A 137ILE A 138ASP A 139 | BJW A 303 (-3.5A)BJW A 303 (-3.6A)NoneBJW A 303 (-3.9A)None | 0.67A | 1yc2D-6enxA:24.0 | 1yc2D-6enxA:40.29 |