SIMILAR PATTERNS OF AMINO ACIDS FOR 1YC2_D_NCAD510

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avb ARCELIN-1

(Phaseolus
vulgaris)
PF00139
(Lectin_legB)
4 PHE A 225
ASN A  55
ILE A  54
ASP A 194
None
1.17A 1yc2D-1avbA:
undetectable
1yc2D-1avbA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3y DNA TOPOISOMERASE VI
A SUBUNIT


(Methanocaldococcus
jannaschii)
PF04406
(TP6A_N)
4 ALA A 118
PHE A 113
ASN A 121
ILE A 123
NA  A 370 ( 3.7A)
None
None
None
1.15A 1yc2D-1d3yA:
2.1
1yc2D-1d3yA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE


(Desulfovibrio
desulfuricans)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
4 ALA A 877
PHE A 544
ASN A 881
ASP A 551
None
1.06A 1yc2D-1dgjA:
undetectable
1yc2D-1dgjA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eke RIBONUCLEASE HII

(Methanocaldococcus
jannaschii)
PF01351
(RNase_HII)
4 ALA A 113
PHE A 121
ILE A   6
ASP A   7
None
1.02A 1yc2D-1ekeA:
undetectable
1yc2D-1ekeA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum)
PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim)
4 ALA A 366
PHE A 418
ILE A  83
ASP A 102
None
0.88A 1yc2D-1fohA:
2.4
1yc2D-1fohA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gdh D-GLYCERATE
DEHYDROGENASE


(Hyphomicrobium
methylovorum)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
4 ALA A  19
ASN A 304
ILE A 307
ASP A 308
None
1.13A 1yc2D-1gdhA:
3.4
1yc2D-1gdhA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT
II


(Salmonella
enterica)
PF00117
(GATase)
4 ALA B 155
PHE B 166
ASN B 146
ASP B 114
None
1.13A 1yc2D-1i1qB:
3.3
1yc2D-1i1qB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q TRPG

(Serratia
marcescens)
PF00117
(GATase)
4 ALA B 158
PHE B 169
ASN B 149
ASP B 116
None
1.14A 1yc2D-1i7qB:
4.3
1yc2D-1i7qB:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q14 HST2 PROTEIN

(Saccharomyces
cerevisiae)
PF02146
(SIR2)
4 ALA A  33
ASN A 116
ILE A 117
ASP A 118
None
0.24A 1yc2D-1q14A:
19.0
1yc2D-1q14A:
30.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae)
PF02146
(SIR2)
5 ALA A  33
PHE A  44
ASN A 116
ILE A 117
ASP A 118
OAD  A1001 (-3.9A)
OAD  A1001 (-3.5A)
None
OAD  A1001 ( 4.4A)
None
0.60A 1yc2D-1q1aA:
20.1
1yc2D-1q1aA:
33.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE


(Oryctolagus
cuniculus)
PF00248
(Aldo_ket_red)
4 ALA A 137
PHE A 139
ILE A 312
ASP A 309
None
0.93A 1yc2D-1q5mA:
undetectable
1yc2D-1q5mA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnr ENDO-1,4-B-D-MANNANA
SE


(Trichoderma
reesei)
PF00150
(Cellulase)
4 ALA A 163
PHE A 162
ILE A   7
ASP A 236
None
1.13A 1yc2D-1qnrA:
undetectable
1yc2D-1qnrA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s5p NAD-DEPENDENT
DEACETYLASE


(Escherichia
coli)
PF02146
(SIR2)
4 ALA A  49
ASN A 130
ILE A 131
ASP A 132
None
0.39A 1yc2D-1s5pA:
21.6
1yc2D-1s5pA:
39.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s7g NAD-DEPENDENT
DEACETYLASE 2


(Archaeoglobus
fulgidus)
PF02146
(SIR2)
4 ALA A  24
ASN A 101
ILE A 102
ASP A 103
NAD  A 703 (-3.8A)
None
None
None
0.17A 1yc2D-1s7gA:
40.2
1yc2D-1s7gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens)
PF00069
(Pkinase)
4 ALA A 168
PHE A 165
ILE A 145
ASP A 202
None
1.02A 1yc2D-1tkiA:
undetectable
1yc2D-1tkiA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhe AEROBIC RESPIRATION
CONTROL PROTEIN ARCA


(Escherichia
coli)
PF00072
(Response_reg)
4 ALA A 114
PHE A  23
ILE A 101
ASP A  99
None
1.17A 1yc2D-1xheA:
5.4
1yc2D-1xheA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0y FRV OPERON PROTEIN
FRVX


(Pyrococcus
horikoshii)
PF05343
(Peptidase_M42)
4 ALA A 219
ASN A  51
ILE A  53
ASP A  47
None
0.98A 1yc2D-1y0yA:
undetectable
1yc2D-1y0yA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akk PHNA-LIKE PROTEIN

(Rhodopseudomonas
palustris)
PF03831
(PhnA)
4 ALA A  72
ASN A  18
ILE A  43
ASP A  17
None
1.13A 1yc2D-2akkA:
undetectable
1yc2D-2akkA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN


(Escherichia
coli)
PF00185
(OTCace)
PF02729
(OTCace_N)
4 ALA A 127
PHE A  59
ASN A 126
ILE A   9
None
1.07A 1yc2D-2atcA:
4.3
1yc2D-2atcA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cit ENDOGLUCANASE H

(Ruminiclostridium
thermocellum)
PF02156
(Glyco_hydro_26)
4 ALA A 147
PHE A 142
ASN A 149
ILE A 102
None
1.17A 1yc2D-2citA:
undetectable
1yc2D-2citA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT


(Klebsiella
oxytoca)
PF08841
(DDR)
4 ALA A  76
ASN A  74
ILE A   7
ASP A   8
None
None
None
MG  A1003 ( 4.1A)
1.18A 1yc2D-2d0oA:
undetectable
1yc2D-2d0oA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfe RIBONUCLEASE HII

(Thermococcus
kodakarensis)
PF01351
(RNase_HII)
4 ALA A 106
PHE A 114
ILE A   6
ASP A   7
None
1.02A 1yc2D-2dfeA:
undetectable
1yc2D-2dfeA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE


(Bacillus
subtilis)
PF12710
(HAD)
4 PHE A 104
ASN A  21
ILE A  22
ASP A  13
None
EDO  A1305 (-3.4A)
EDO  A1306 ( 3.8A)
None
1.11A 1yc2D-2feaA:
5.4
1yc2D-2feaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)


(Homo sapiens)
PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP)
4 ALA A 150
ASN A 146
ILE A 145
ASP A 127
GSH  A 503 (-4.8A)
MG  A 501 ( 2.7A)
None
SO4  A 505 ( 4.8A)
1.18A 1yc2D-2hgsA:
undetectable
1yc2D-2hgsA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2


(Saccharomyces
cerevisiae)
PF02146
(SIR2)
PF04574
(DUF592)
5 ALA A 263
PHE A 274
ASN A 345
ILE A 346
ASP A 347
XYQ  A1222 (-3.4A)
NCA  A 900 ( 3.9A)
None
NCA  A 900 (-4.6A)
None
0.56A 1yc2D-2hjhA:
19.3
1yc2D-2hjhA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4v UNCHARACTERIZED
PROTEIN PA1076


(Pseudomonas
aeruginosa)
PF16703
(DUF5064)
4 PHE A  54
ASN A  24
ILE A  23
ASP A  22
None
0.93A 1yc2D-2k4vA:
undetectable
1yc2D-2k4vA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2v ALPHA-2,3-SIALYLTRAN
SFERASE


(Campylobacter
jejuni)
PF06002
(CST-I)
4 ALA A 181
PHE A 196
ILE A 258
ASP A 257
None
CSF  A1001 (-3.5A)
None
None
1.14A 1yc2D-2p2vA:
undetectable
1yc2D-2p2vA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 ALA A 500
ASN A 473
ILE A 471
ASP A 447
None
None
None
MG  A1001 ( 2.8A)
0.98A 1yc2D-2q27A:
13.8
1yc2D-2q27A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA


(Bacillus sp.
TA2.A1)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
4 ALA D  75
ASN D  28
ILE D  30
ASP D  72
None
1.12A 1yc2D-2qe7D:
undetectable
1yc2D-2qe7D:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpq PROTEIN BUG27

(Bordetella
pertussis)
PF03401
(TctC)
4 ALA A 100
ASN A  98
ILE A  97
ASP A 273
None
1.00A 1yc2D-2qpqA:
undetectable
1yc2D-2qpqA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei)
PF00303
(Thymidylat_synt)
4 ALA A 220
PHE A 255
ASN A 229
ILE A 230
None
None
UFP  A 529 (-3.7A)
None
1.00A 1yc2D-2tddA:
undetectable
1yc2D-2tddA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsi FAD SYNTHETASE

(Saccharomyces
cerevisiae)
PF01507
(PAPS_reduct)
4 ALA A  33
ASN A 201
ILE A 202
ASP A 198
None
1.09A 1yc2D-2wsiA:
2.4
1yc2D-2wsiA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyr COBALT-ACTIVATED
PEPTIDASE TET1


(Pyrococcus
horikoshii)
PF05343
(Peptidase_M42)
4 ALA A 211
ASN A  44
ILE A  46
ASP A  40
None
0.92A 1yc2D-2wyrA:
undetectable
1yc2D-2wyrA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1


(Arabidopsis
thaliana)
PF07859
(Abhydrolase_3)
4 ALA A 262
PHE A 251
ASN A 199
ILE A 196
None
0.88A 1yc2D-2zsiA:
2.2
1yc2D-2zsiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asp CAPSID PROTEIN

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
4 ALA A 444
ASN A 440
ILE A 398
ASP A 397
None
1.14A 1yc2D-3aspA:
undetectable
1yc2D-3aspA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b13 DEDICATOR OF
CYTOKINESIS PROTEIN
2


(Homo sapiens)
PF06920
(DHR-2)
4 ALA A1549
PHE A1550
ASN A1457
ASP A1454
None
1.17A 1yc2D-3b13A:
undetectable
1yc2D-3b13A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6a TERMINASE LARGE
SUBUNIT


(Escherichia
virus RB49)
PF17289
(Terminase_6C)
4 ALA A 560
PHE A 556
ILE A 413
ASP A 414
None
1.11A 1yc2D-3c6aA:
undetectable
1yc2D-3c6aA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co8 ALANINE RACEMASE

(Oenococcus oeni)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 PHE A 164
ASN A 134
ILE A 136
ASP A 130
None
0.99A 1yc2D-3co8A:
undetectable
1yc2D-3co8A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Streptococcus
pneumoniae)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
4 ALA A 580
ASN A 579
ILE A 591
ASP A 588
None
CA  A2000 (-2.8A)
None
CA  A2000 (-2.3A)
0.99A 1yc2D-3ecqA:
undetectable
1yc2D-3ecqA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE


(Desulfovibrio
gigas)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
4 ALA A 877
PHE A 542
ASN A 881
ASP A 549
None
1.11A 1yc2D-3fahA:
undetectable
1yc2D-3fahA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb0 PEPTIDASE T

(Bacillus cereus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 ALA A 147
ASN A  57
ILE A  59
ASP A  45
None
0.97A 1yc2D-3gb0A:
undetectable
1yc2D-3gb0A:
24.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jr3 NAD-DEPENDENT
DEACETYLASE


(Thermotoga
maritima)
PF02146
(SIR2)
4 ALA A  22
ASN A  99
ILE A 100
ASP A 101
None
0.19A 1yc2D-3jr3A:
26.7
1yc2D-3jr3A:
42.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3b ES1 FAMILY PROTEIN

(Ehrlichia
chaffeensis)
PF01965
(DJ-1_PfpI)
4 ALA A 151
ASN A 186
ILE A 188
ASP A 183
None
0.98A 1yc2D-3l3bA:
5.6
1yc2D-3l3bA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll9 ISOPENTENYL
PHOSPHATE KINASE


(Methanothermobacter
thermautotrophicus)
PF00696
(AA_kinase)
4 ALA A 243
ASN A  25
ILE A  11
ASP A  22
None
0.77A 1yc2D-3ll9A:
4.0
1yc2D-3ll9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH


(Actinoplanes
sp. SE50/110)
PF01547
(SBP_bac_1)
4 ALA A 229
PHE A 171
ASN A 230
ASP A 381
None
1.09A 1yc2D-3oo9A:
undetectable
1yc2D-3oo9A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN


(Pseudomonas
fluorescens)
PF00563
(EAL)
PF00990
(GGDEF)
4 ALA A 358
ASN A 394
ILE A 362
ASP A 342
EDO  A   5 (-3.3A)
EDO  A   5 (-3.5A)
None
None
1.07A 1yc2D-3pjxA:
undetectable
1yc2D-3pjxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6


(Homo sapiens)
PF02146
(SIR2)
4 ALA A  51
PHE A  62
ASN A 112
ASP A 114
A2N  A1000 (-3.5A)
A2N  A1000 (-3.8A)
None
None
0.67A 1yc2D-3pkjA:
22.7
1yc2D-3pkjA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9j MEMBER OF DUF4221
FAMILY


(Bacteroides
vulgatus)
PF13970
(DUF4221)
4 ALA A 161
ASN A 160
ILE A 295
ASP A 229
None
1.10A 1yc2D-3s9jA:
undetectable
1yc2D-3s9jA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uiw GLUTAREDOXIN 2

(Danio rerio)
PF00462
(Glutaredoxin)
4 ALA A  43
PHE A  47
ILE A  91
ASP A  96
None
1.16A 1yc2D-3uiwA:
undetectable
1yc2D-3uiwA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6


(Homo sapiens)
PF02146
(SIR2)
4 ALA A  51
PHE A  62
ASN A 112
ASP A 114
APR  A1296 (-3.7A)
APR  A1296 (-3.6A)
None
None
0.67A 1yc2D-3zg6A:
21.8
1yc2D-3zg6A:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq1 SBSB PROTEIN

(Geobacillus
stearothermophilus)
no annotation 4 ALA C 737
PHE C 845
ILE C 814
ASP C 808
None
1.13A 1yc2D-4aq1C:
undetectable
1yc2D-4aq1C:
13.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL


(Homo sapiens)
PF02146
(SIR2)
4 ALA A 146
ASN A 229
ILE A 230
ASP A 231
CNA  A1395 (-3.1A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
0.34A 1yc2D-4bn5A:
20.6
1yc2D-4bn5A:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpx DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT,
DNA PRIMASE LARGE
SUBUNIT


(Homo sapiens)
PF04104
(DNA_primase_lrg)
4 ALA B 224
ASN B 220
ILE B 217
ASP B 193
None
1.11A 1yc2D-4bpxB:
undetectable
1yc2D-4bpxB:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus)
PF00303
(Thymidylat_synt)
4 ALA A 223
PHE A 258
ASN A 232
ILE A 233
UMP  A 501 (-4.2A)
None
UMP  A 501 (-2.7A)
None
0.95A 1yc2D-4dq1A:
undetectable
1yc2D-4dq1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1


(Homo sapiens)
PF00069
(Pkinase)
4 ALA A 161
PHE A 158
ILE A 136
ASP A 203
None
1.17A 1yc2D-4euuA:
undetectable
1yc2D-4euuA:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL


(Homo sapiens)
PF02146
(SIR2)
4 ALA A  59
ASN A 141
ILE A 142
ASP A 143
CNA  A 402 (-3.0A)
CNA  A 402 (-4.1A)
CNA  A 402 (-4.7A)
CNA  A 402 (-3.7A)
0.38A 1yc2D-4g1cA:
25.2
1yc2D-4g1cA:
39.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL


(Homo sapiens)
PF02146
(SIR2)
4 ALA A  59
PHE A  70
ILE A 142
ASP A 143
CNA  A 402 (-3.0A)
CNA  A 402 (-3.2A)
CNA  A 402 (-4.7A)
CNA  A 402 (-3.7A)
1.09A 1yc2D-4g1cA:
25.2
1yc2D-4g1cA:
39.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Salipiger
bermudensis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ALA A 192
PHE A 215
ILE A 173
ASP A 172
None
1.12A 1yc2D-4h2hA:
undetectable
1yc2D-4h2hA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2


(Saccharomyces
cerevisiae)
PF02146
(SIR2)
PF04574
(DUF592)
5 ALA A 263
PHE A 274
ASN A 345
ILE A 346
ASP A 347
APR  A 602 (-3.3A)
APR  A 602 (-3.5A)
None
None
None
0.59A 1yc2D-4iaoA:
23.7
1yc2D-4iaoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF00171
(Aldedh)
4 PHE A 406
ASN A 364
ILE A 359
ASP A 361
None
1.13A 1yc2D-4idmA:
4.0
1yc2D-4idmA:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1


(Homo sapiens)
PF02146
(SIR2)
4 ALA A 262
ASN A 346
ILE A 347
ASP A 348
None
0.34A 1yc2D-4ig9A:
24.1
1yc2D-4ig9A:
32.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN


(Ruegeria sp.
TM1040)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ALA A  34
ASN A  58
ILE A  62
ASP A  11
None
0.96A 1yc2D-4ip4A:
undetectable
1yc2D-4ip4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv5 ASPARTATE
CARBAMOYLTRANSFERASE
, PUTATIVE


(Trypanosoma
cruzi)
PF00185
(OTCace)
PF02729
(OTCace_N)
4 ALA A 134
PHE A  69
ASN A 133
ILE A  15
None
1.14A 1yc2D-4iv5A:
4.6
1yc2D-4iv5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN


(Desulfitobacterium
hafniense)
PF02310
(B12-binding)
PF02607
(B12-binding_2)
4 ALA A  73
PHE A  42
ASN A  20
ASP A  24
None
1.00A 1yc2D-4jgiA:
5.2
1yc2D-4jgiA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans)
PF00343
(Phosphorylase)
4 ALA A 110
PHE A  59
ASN A 278
ILE A  55
None
1.10A 1yc2D-4l22A:
4.9
1yc2D-4l22A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhp GLUTAMINYL CYCLASE,
PUTATIVE


(Ixodes
scapularis)
PF04389
(Peptidase_M28)
4 PHE A 302
ASN A 110
ILE A 112
ASP A  95
None
1.17A 1yc2D-4mhpA:
undetectable
1yc2D-4mhpA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR


(Desulfitobacterium
hafniense)
PF13458
(Peripla_BP_6)
4 ALA A 201
PHE A 199
ILE A 126
ASP A 123
None
1.13A 1yc2D-4mlcA:
4.7
1yc2D-4mlcA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6y AMINOPEPTIDASE

(Thermotoga
maritima)
PF05343
(Peptidase_M42)
4 ALA A 204
ASN A  43
ILE A  45
ASP A  39
None
0.92A 1yc2D-4p6yA:
undetectable
1yc2D-4p6yA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN


(Legionella
pneumophila)
PF13855
(LRR_8)
4 ALA A  22
PHE A  19
ASN A  28
ILE A  59
None
1.17A 1yc2D-4q62A:
undetectable
1yc2D-4q62A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE


(Thermococcus
kodakarensis)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
4 ALA B 745
ASN B 743
ILE B 742
ASP B 911
None
1.14A 1yc2D-4qiwB:
undetectable
1yc2D-4qiwB:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Dictyostelium
purpureum)
PF05450
(Nicastrin)
4 ALA A 380
PHE A 390
ILE A 448
ASP A 447
None
0.77A 1yc2D-4r12A:
undetectable
1yc2D-4r12A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqk LECTIN 2

(Agrocybe
aegerita)
PF13517
(VCBS)
4 ALA A  36
ASN A  35
ILE A  22
ASP A  21
None
1.12A 1yc2D-4tqkA:
undetectable
1yc2D-4tqkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR


(Bacillus
subtilis)
PF00155
(Aminotran_1_2)
PF00392
(GntR)
4 ALA A 269
ASN A 303
ILE A 276
ASP A 299
None
0.89A 1yc2D-4tv7A:
3.5
1yc2D-4tv7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides)
PF02324
(Glyco_hydro_70)
4 ALA A1802
PHE A1816
ILE A1809
ASP A2073
None
None
None
TYI  A2075 (-3.9A)
1.15A 1yc2D-4tvcA:
undetectable
1yc2D-4tvcA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8i LYSYL AMINOPEPTIDASE

(Pyrococcus
furiosus)
PF05343
(Peptidase_M42)
4 ALA A 214
ASN A  46
ILE A  48
ASP A  42
None
0.88A 1yc2D-4x8iA:
undetectable
1yc2D-4x8iA:
24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2


(Homo sapiens)
PF02146
(SIR2)
4 ALA A  85
ASN A 168
ILE A 169
ASP A 170
None
0.31A 1yc2D-4y6oA:
20.0
1yc2D-4y6oA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN


(Agrobacterium
vitis)
PF13407
(Peripla_BP_4)
4 ALA A 211
ASN A 212
ILE A 215
ASP A 214
None
1.14A 1yc2D-4y9tA:
5.7
1yc2D-4y9tA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzt CELLULOSE HYDROLASE

(Bacillus
licheniformis)
PF00150
(Cellulase)
PF03442
(CBM_X2)
4 ALA A 419
ASN A 333
ILE A 335
ASP A 285
None
1.16A 1yc2D-4yztA:
undetectable
1yc2D-4yztA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1


(Homo sapiens)
PF02146
(SIR2)
4 ALA A 262
ASN A 346
ILE A 347
ASP A 348
None
0.35A 1yc2D-4zzhA:
23.6
1yc2D-4zzhA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3m CEA1

(Komagataella
pastoris)
PF10528
(GLEYA)
4 ALA A 207
PHE A  89
ASN A 202
ASP A 137
None
None
CA  A 500 (-3.0A)
NAG  A 501 ( 2.5A)
1.14A 1yc2D-5a3mA:
undetectable
1yc2D-5a3mA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Streptococcus
pneumoniae)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
4 ALA A 580
ASN A 579
ILE A 591
ASP A 588
None
CA  A2419 (-3.0A)
None
CA  A2419 (-2.2A)
1.02A 1yc2D-5a55A:
undetectable
1yc2D-5a55A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1


(Homo sapiens)
PF02146
(SIR2)
4 ALA A 262
ASN A 346
ILE A 347
ASP A 348
None
0.34A 1yc2D-5btrA:
23.7
1yc2D-5btrA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 SULPHATE TRANSPORTER

(Deinococcus
geothermalis)
PF00916
(Sulfate_transp)
PF01740
(STAS)
4 ALA A 476
PHE A 445
ILE A 438
ASP A 439
None
1.04A 1yc2D-5da0A:
undetectable
1yc2D-5da0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE


(Bacillus
megaterium)
PF00067
(p450)
4 ALA A  99
ASN A 253
ILE A 254
ASP A 250
None
1.16A 1yc2D-5e78A:
undetectable
1yc2D-5e78A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2


(Homo sapiens)
PF02146
(SIR2)
5 ALA A  85
PHE A  96
ASN A 168
ILE A 169
ASP A 170
SO4  A1357 ( 4.1A)
None
None
None
None
1.03A 1yc2D-5fyqA:
20.1
1yc2D-5fyqA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii)
no annotation 4 ALA A 124
PHE A 171
ILE A 157
ASP A 154
None
None
None
GDP  A 501 (-2.8A)
1.11A 1yc2D-5h7kA:
undetectable
1yc2D-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hg0 PANTOTHENATE
SYNTHETASE


(Francisella
tularensis)
PF02569
(Pantoate_ligase)
4 ALA A   4
ASN A   6
ILE A   7
ASP A  96
None
1.14A 1yc2D-5hg0A:
undetectable
1yc2D-5hg0A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu7 COATOMER SUBUNIT
BETA


(Chaetomium
thermophilum)
PF01602
(Adaptin_N)
4 ALA A 204
PHE A 193
ILE A 230
ASP A 233
None
1.11A 1yc2D-5mu7A:
undetectable
1yc2D-5mu7A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mw5 PROTEIN JAGGED-2

(Homo sapiens)
PF01414
(DSL)
PF07657
(MNNL)
4 ALA A 205
ASN A 173
ILE A 172
ASP A 176
None
1.18A 1yc2D-5mw5A:
undetectable
1yc2D-5mw5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE


(Trypanosoma
brucei)
PF00883
(Peptidase_M17)
4 ALA A 345
ASN A 344
ILE A 291
ASP A 294
None
None
None
MN  A 602 (-2.3A)
1.09A 1yc2D-5nsqA:
undetectable
1yc2D-5nsqA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nth PUTATIVE
AMINOPEPTIDASE


(Leishmania
major)
PF00883
(Peptidase_M17)
4 ALA A 363
ASN A 362
ILE A 301
ASP A 304
None
None
None
MN  A 603 (-2.6A)
1.04A 1yc2D-5nthA:
undetectable
1yc2D-5nthA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2


(Leishmania
infantum)
no annotation 4 ALA A  40
ASN A 125
ILE A 126
ASP A 127
None
0.26A 1yc2D-5ol0A:
23.3
1yc2D-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron)
no annotation 4 ALA A 272
PHE A 266
ILE A 226
ASP A 252
None
1.12A 1yc2D-5olpA:
undetectable
1yc2D-5olpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR


(synthetic
construct)
no annotation 4 ALA A  53
ASN A  64
ILE A  63
ASP A  87
None
1.14A 1yc2D-5w7qA:
3.8
1yc2D-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR


(synthetic
construct)
no annotation 4 ALA A  97
ASN A  14
ILE A  15
ASP A 100
None
1.18A 1yc2D-5w7qA:
3.8
1yc2D-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4r S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus)
no annotation 4 ALA A 336
PHE A 323
ILE A  48
ASP A  54
None
1.10A 1yc2D-5x4rA:
undetectable
1yc2D-5x4rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus)
PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
4 ALA A 336
PHE A 323
ILE A  48
ASP A  54
None
1.09A 1yc2D-5x59A:
undetectable
1yc2D-5x59A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y09 PROTEASE DO-LIKE 9

(Arabidopsis
thaliana)
no annotation 4 ALA A 293
ASN A 167
ILE A 201
ASP A 200
None
1.03A 1yc2D-5y09A:
undetectable
1yc2D-5y09A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6auj THYMIDYLATE SYNTHASE

(Elizabethkingia
anophelis)
PF00303
(Thymidylat_synt)
4 ALA A 176
PHE A 211
ASN A 185
ILE A 186
None
None
PGE  A 301 ( 4.9A)
None
0.92A 1yc2D-6aujA:
undetectable
1yc2D-6aujA:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6enx NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL


(Danio rerio)
no annotation 5 ALA A  55
PHE A  66
ASN A 137
ILE A 138
ASP A 139
BJW  A 303 (-3.5A)
BJW  A 303 (-3.6A)
None
BJW  A 303 (-3.9A)
None
0.67A 1yc2D-6enxA:
24.0
1yc2D-6enxA:
40.29