SIMILAR PATTERNS OF AMINO ACIDS FOR 1YC2_A_NCAA506_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ae1 | TROPINONEREDUCTASE-I (Daturastramonium) |
PF13561(adh_short_C2) | 4 | SER A 148PHE A 96ASN A 101ILE A 102 | None | 1.01A | 1yc2A-1ae1A:5.0 | 1yc2A-1ae1A:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aso | ASCORBATE OXIDASE (Cucurbita pepo) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | ALA A 72SER A 79PHE A 93ILE A 59 | None | 1.01A | 1yc2A-1asoA:undetectable | 1yc2A-1asoA:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ea6 | PMS1 PROTEIN HOMOLOG2 (Homo sapiens) |
PF01119(DNA_mis_repair)PF13589(HATPase_c_3) | 4 | ALA A 196SER A 220ASN A 226ILE A 227 | None | 0.78A | 1yc2A-1ea6A:undetectable | 1yc2A-1ea6A:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eke | RIBONUCLEASE HII (Methanocaldococcusjannaschii) |
PF01351(RNase_HII) | 4 | ALA A 113PHE A 121ILE A 6ASP A 7 | None | 1.04A | 1yc2A-1ekeA:undetectable | 1yc2A-1ekeA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eyw | PHOSPHOTRIESTERASE (Brevundimonasdiminuta) |
PF02126(PTE) | 4 | PHE A 72ASN A 312ILE A 313ASP A 315 | None | 0.96A | 1yc2A-1eywA:undetectable | 1yc2A-1eywA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8k | ARSENITE OXIDASE (Alcaligenesfaecalis) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | ALA A 466SER A 463ILE A 445ASP A 441 | None | 0.90A | 1yc2A-1g8kA:3.1 | 1yc2A-1g8kA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h65 | CHLOROPLAST OUTERENVELOPE PROTEINOEP34 (Pisum sativum) |
PF04548(AIG1) | 4 | SER A 81PHE A 87ASN A 90ILE A 42 | None | 1.01A | 1yc2A-1h65A:undetectable | 1yc2A-1h65A:24.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1it2 | HEMOGLOBIN (Eptatretusburgeri) |
PF00042(Globin) | 4 | ALA A 48SER A 51PHE A 45ILE A 112 | ALA A 48 ( 0.0A)SER A 51 (-0.0A)PHE A 45 ( 1.3A)ILE A 112 ( 0.4A) | 1.01A | 1yc2A-1it2A:undetectable | 1yc2A-1it2A:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jl5 | OUTER PROTEIN YOPM (Yersinia pestis) |
PF12468(TTSSLRR) | 4 | ALA A1304SER A1285ASN A1303ASP A1283 | None | 0.97A | 1yc2A-1jl5A:undetectable | 1yc2A-1jl5A:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js8 | HEMOCYANIN (Enteroctopusdofleini) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 4 | ALA A2673SER A2676PHE A2646ASP A2809 | None | 0.95A | 1yc2A-1js8A:undetectable | 1yc2A-1js8A:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nbw | GLYCEROL DEHYDRATASEREACTIVASE ALPHASUBUNIT (Klebsiellapneumoniae) |
PF08841(DDR) | 4 | ALA A 17SER A 31ASN A 594ILE A 586 | None | 0.88A | 1yc2A-1nbwA:3.7 | 1yc2A-1nbwA:17.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q14 | HST2 PROTEIN (Saccharomycescerevisiae) |
PF02146(SIR2) | 5 | ALA A 33SER A 36ASN A 116ILE A 117ASP A 118 | None | 0.15A | 1yc2A-1q14A:19.2 | 1yc2A-1q14A:30.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q1a | HST2 PROTEIN (Saccharomycescerevisiae) |
PF02146(SIR2) | 6 | ALA A 33SER A 36PHE A 44ASN A 116ILE A 117ASP A 118 | OAD A1001 (-3.9A)NoneOAD A1001 (-3.5A)NoneOAD A1001 ( 4.4A)None | 0.70A | 1yc2A-1q1aA:20.4 | 1yc2A-1q1aA:33.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 4 | ALA A 193SER A 147PHE A 108ILE A 165 | None | 1.02A | 1yc2A-1q5aA:undetectable | 1yc2A-1q5aA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r47 | ALPHA-GALACTOSIDASEA (Homo sapiens) |
PF16499(Melibiase_2)PF17450(Melibiase_2_C) | 4 | ALA A 348SER A 345ILE A 319ASP A 322 | None | 1.04A | 1yc2A-1r47A:undetectable | 1yc2A-1r47A:21.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1s5p | NAD-DEPENDENTDEACETYLASE (Escherichiacoli) |
PF02146(SIR2) | 5 | ALA A 49SER A 52ASN A 130ILE A 131ASP A 132 | None | 0.35A | 1yc2A-1s5pA:21.9 | 1yc2A-1s5pA:39.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1s7g | NAD-DEPENDENTDEACETYLASE 2 (Archaeoglobusfulgidus) |
PF02146(SIR2) | 5 | ALA A 24SER A 27ASN A 101ILE A 102ASP A 103 | NAD A 703 (-3.8A)NoneNoneNoneNone | 0.14A | 1yc2A-1s7gA:42.4 | 1yc2A-1s7gA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1thg | LIPASE 2 (Galactomycescandidus) |
PF00135(COesterase) | 4 | ALA A 382SER A 386PHE A 379ASP A 539 | None | 0.99A | 1yc2A-1thgA:undetectable | 1yc2A-1thgA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tki | TITIN (Homo sapiens) |
PF00069(Pkinase) | 4 | ALA A 168PHE A 165ILE A 145ASP A 202 | None | 0.97A | 1yc2A-1tkiA:undetectable | 1yc2A-1tkiA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhe | AMINOPEPTIDASE/GLUCANASE HOMOLOG (Bacillussubtilis) |
PF05343(Peptidase_M42) | 4 | ALA A 241SER A 254ILE A 295ASP A 293 | None | 0.98A | 1yc2A-1vheA:undetectable | 1yc2A-1vheA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xpw | LOC51668 PROTEIN (Homo sapiens) |
PF00754(F5_F8_type_C) | 4 | ALA A 133SER A 132ILE A 4ASP A 5 | None | 1.02A | 1yc2A-1xpwA:undetectable | 1yc2A-1xpwA:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0o | DIOLDEHYDRATASE-REACTIVATING FACTOR LARGESUBUNIT (Klebsiellaoxytoca) |
PF08841(DDR) | 4 | ALA A 17SER A 32ASN A 592ILE A 584 | None | 0.89A | 1yc2A-2d0oA:undetectable | 1yc2A-2d0oA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fvl | ALDO-KETO REDUCTASEFAMILY 1, MEMBER C4 (Homo sapiens) |
PF00248(Aldo_ket_red) | 4 | ALA A 269SER A 271ASN A 280ILE A 281 | NAP A1001 ( 4.9A)NAP A1001 (-2.4A)NAP A1001 (-3.2A)None | 1.02A | 1yc2A-2fvlA:undetectable | 1yc2A-2fvlA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hjh | NAD-DEPENDENTHISTONE DEACETYLASESIR2 (Saccharomycescerevisiae) |
PF02146(SIR2)PF04574(DUF592) | 6 | ALA A 263SER A 266PHE A 274ASN A 345ILE A 346ASP A 347 | XYQ A1222 (-3.4A)NoneNCA A 900 ( 3.9A)NoneNCA A 900 (-4.6A)None | 0.63A | 1yc2A-2hjhA:19.5 | 1yc2A-2hjhA:25.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k4v | UNCHARACTERIZEDPROTEIN PA1076 (Pseudomonasaeruginosa) |
PF16703(DUF5064) | 4 | PHE A 54ASN A 24ILE A 23ASP A 22 | None | 0.95A | 1yc2A-2k4vA:undetectable | 1yc2A-2k4vA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mjp | PYROPHOSPHATASE (Methanocaldococcusjannaschii) |
PF01725(Ham1p_like) | 4 | ALA A 150SER A 153ASN A 98ILE A 101 | None | 0.92A | 1yc2A-2mjpA:undetectable | 1yc2A-2mjpA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o14 | HYPOTHETICAL PROTEINYXIM (Bacillussubtilis) |
PF13472(Lipase_GDSL_2) | 4 | ALA A 57SER A 58ASN A 97ASP A 117 | None | 0.96A | 1yc2A-2o14A:undetectable | 1yc2A-2o14A:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q27 | OXALYL-COADECARBOXYLASE (Escherichiacoli) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | ALA A 500ASN A 473ILE A 471ASP A 447 | NoneNoneNone MG A1001 ( 2.8A) | 0.94A | 1yc2A-2q27A:13.6 | 1yc2A-2q27A:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qpq | PROTEIN BUG27 (Bordetellapertussis) |
PF03401(TctC) | 4 | ALA A 100ASN A 98ILE A 97ASP A 273 | None | 1.03A | 1yc2A-2qpqA:undetectable | 1yc2A-2qpqA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r5j | MAJOR CAPSID PROTEINL1 (Alphapapillomavirus9) |
PF00500(Late_protein_L1) | 4 | ALA A 345SER A 347ASN A 357ASP A 350 | None | 0.95A | 1yc2A-2r5jA:undetectable | 1yc2A-2r5jA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wbe | BIPOLAR KINESINKRP-130 (Drosophilamelanogaster) |
PF00225(Kinesin) | 4 | SER C 112ASN C 104ILE C 119ASP C 115 | None | 1.02A | 1yc2A-2wbeC:undetectable | 1yc2A-2wbeC:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wyr | COBALT-ACTIVATEDPEPTIDASE TET1 (Pyrococcushorikoshii) |
PF05343(Peptidase_M42) | 4 | ALA A 211ASN A 44ILE A 46ASP A 40 | None | 1.00A | 1yc2A-2wyrA:undetectable | 1yc2A-2wyrA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsi | PROBABLE GIBBERELLINRECEPTOR GID1L1 (Arabidopsisthaliana) |
PF07859(Abhydrolase_3) | 4 | ALA A 262PHE A 251ASN A 199ILE A 196 | None | 1.03A | 1yc2A-2zsiA:2.1 | 1yc2A-2zsiA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3brz | TODX (Pseudomonasputida) |
PF03349(Toluene_X) | 4 | ALA A 237SER A 21ILE A 299ASP A 298 | None | 1.01A | 1yc2A-3brzA:undetectable | 1yc2A-3brzA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c5i | CHOLINE KINASE (Plasmodiumknowlesi) |
PF01633(Choline_kinase) | 4 | SER A 260PHE A 339ILE A 257ASP A 258 | NoneNone CA A 371 (-4.4A)None | 1.00A | 1yc2A-3c5iA:undetectable | 1yc2A-3c5iA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clw | CONSERVED EXPORTEDPROTEIN (Bacteroidesfragilis) |
PF14587(Glyco_hydr_30_2) | 4 | SER A 242ASN A 292ILE A 250ASP A 238 | None | 1.00A | 1yc2A-3clwA:undetectable | 1yc2A-3clwA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e10 | PUTATIVE NADHOXIDASE (Clostridiumacetobutylicum) |
PF00881(Nitroreductase) | 4 | PHE A 129ASN A 52ILE A 53ASP A 49 | EDO A 503 (-4.0A)EDO A 503 (-3.4A)NoneNone | 0.99A | 1yc2A-3e10A:undetectable | 1yc2A-3e10A:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ecq | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Streptococcuspneumoniae) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 4 | ALA A 580ASN A 579ILE A 591ASP A 588 | None CA A2000 (-2.8A)None CA A2000 (-2.3A) | 0.97A | 1yc2A-3ecqA:undetectable | 1yc2A-3ecqA:9.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ek9 | SPRYDOMAIN-CONTAININGSOCS BOX PROTEIN 2 (Mus musculus) |
PF00622(SPRY) | 4 | SER A 74ASN A 56ILE A 57ASP A 76 | None | 1.04A | 1yc2A-3ek9A:undetectable | 1yc2A-3ek9A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fi8 | CHOLINE KINASE (Plasmodiumfalciparum) |
PF01633(Choline_kinase) | 4 | SER A 330PHE A 409ILE A 327ASP A 328 | None | 1.03A | 1yc2A-3fi8A:undetectable | 1yc2A-3fi8A:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gb0 | PEPTIDASE T (Bacillus cereus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | ALA A 147ASN A 57ILE A 59ASP A 45 | None | 1.03A | 1yc2A-3gb0A:undetectable | 1yc2A-3gb0A:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gme | POLYRIBONUCLEOTIDENUCLEOTIDYLTRANSFERASE (Escherichiacoli) |
PF01138(RNase_PH)PF03725(RNase_PH_C)PF03726(PNPase) | 4 | ALA A 441SER A 439PHE A 343ILE A 464 | None | 0.99A | 1yc2A-3gmeA:undetectable | 1yc2A-3gmeA:21.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3jr3 | NAD-DEPENDENTDEACETYLASE (Thermotogamaritima) |
PF02146(SIR2) | 5 | ALA A 22SER A 25ASN A 99ILE A 100ASP A 101 | None | 0.23A | 1yc2A-3jr3A:26.9 | 1yc2A-3jr3A:42.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ll9 | ISOPENTENYLPHOSPHATE KINASE (Methanothermobacterthermautotrophicus) |
PF00696(AA_kinase) | 4 | ALA A 243ASN A 25ILE A 11ASP A 22 | None | 0.77A | 1yc2A-3ll9A:2.9 | 1yc2A-3ll9A:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pkj | NAD-DEPENDENTDEACETYLASESIRTUIN-6 (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 51SER A 54PHE A 62ASN A 112ASP A 114 | A2N A1000 (-3.5A)NoneA2N A1000 (-3.8A)NoneNone | 0.71A | 1yc2A-3pkjA:22.7 | 1yc2A-3pkjA:26.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sgz | HYDROXYACID OXIDASE2 (Rattusnorvegicus) |
PF01070(FMN_dh) | 4 | ALA A 257SER A 258ASN A 37ILE A 38 | None | 1.02A | 1yc2A-3sgzA:undetectable | 1yc2A-3sgzA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tl3 | SHORT-CHAIN TYPEDEHYDROGENASE/REDUCTASE (Mycobacteriumulcerans) |
PF00106(adh_short) | 5 | ALA A 14SER A 15PHE A 52ASN A 87ILE A 37 | None | 1.36A | 1yc2A-3tl3A:5.0 | 1yc2A-3tl3A:24.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zg6 | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-6 (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 51SER A 54PHE A 62ASN A 112ASP A 114 | APR A1296 (-3.7A)NoneAPR A1296 (-3.6A)NoneNone | 0.73A | 1yc2A-3zg6A:21.7 | 1yc2A-3zg6A:30.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aq2 | HOMOGENTISATE1,2-DIOXYGENASE (Pseudomonasputida) |
PF04209(HgmA) | 4 | ALA A 118SER A 404PHE A 338ILE A 133 | None | 0.88A | 1yc2A-4aq2A:undetectable | 1yc2A-4aq2A:20.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4bn5 | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-3,MITOCHONDRIAL (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 146SER A 149ASN A 229ILE A 230ASP A 231 | CNA A1395 (-3.1A)CNA A1395 (-4.3A)CNA A1395 (-3.7A)SR7 A1396 (-4.8A)CNA A1395 (-3.5A) | 0.40A | 1yc2A-4bn5A:20.9 | 1yc2A-4bn5A:31.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4de8 | CPS2A (Streptococcuspneumoniae) |
PF02916(DNA_PPF)PF03816(LytR_cpsA_psr) | 4 | ALA A 267SER A 245ASN A 248ILE A 249 | None | 0.90A | 1yc2A-4de8A:undetectable | 1yc2A-4de8A:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dq1 | THYMIDYLATE SYNTHASE (Staphylococcusaureus) |
PF00303(Thymidylat_synt) | 4 | ALA A 223PHE A 258ASN A 232ILE A 233 | UMP A 501 (-4.2A)NoneUMP A 501 (-2.7A)None | 1.00A | 1yc2A-4dq1A:undetectable | 1yc2A-4dq1A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ew6 | D-GALACTOSE-1-DEHYDROGENASE PROTEIN (Rhizobium etli) |
PF01408(GFO_IDH_MocA) | 4 | SER A 229PHE A 220ILE A 232ASP A 231 | None | 1.03A | 1yc2A-4ew6A:5.2 | 1yc2A-4ew6A:22.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g1c | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Homo sapiens) |
PF02146(SIR2) | 6 | ALA A 59SER A 62PHE A 70ASN A 141ILE A 142ASP A 143 | CNA A 402 (-3.0A)CNA A 402 ( 4.1A)CNA A 402 (-3.2A)CNA A 402 (-4.1A)CNA A 402 (-4.7A)CNA A 402 (-3.7A) | 0.88A | 1yc2A-4g1cA:25.4 | 1yc2A-4g1cA:39.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iao | NAD-DEPENDENTHISTONE DEACETYLASESIR2 (Saccharomycescerevisiae) |
PF02146(SIR2)PF04574(DUF592) | 5 | ALA A 263SER A 266ASN A 345ILE A 346ASP A 347 | APR A 602 (-3.3A)NoneNoneNoneNone | 0.26A | 1yc2A-4iaoA:23.8 | 1yc2A-4iaoA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iao | NAD-DEPENDENTHISTONE DEACETYLASESIR2 (Saccharomycescerevisiae) |
PF02146(SIR2)PF04574(DUF592) | 5 | ALA A 263SER A 266PHE A 274ASN A 345ILE A 346 | APR A 602 (-3.3A)NoneAPR A 602 (-3.5A)NoneNone | 0.71A | 1yc2A-4iaoA:23.8 | 1yc2A-4iaoA:19.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ig9 | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 262SER A 265ASN A 346ILE A 347ASP A 348 | None | 0.24A | 1yc2A-4ig9A:23.8 | 1yc2A-4ig9A:32.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ip4 | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME-LIKE PROTEIN (Ruegeria sp.TM1040) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ALA A 34ASN A 58ILE A 62ASP A 11 | None | 0.97A | 1yc2A-4ip4A:undetectable | 1yc2A-4ip4A:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j2u | ENOYL-COA HYDRATASE (Rhodobactersphaeroides) |
PF16113(ECH_2) | 4 | ALA A 54SER A 18PHE A 60ILE A 15 | None | 1.01A | 1yc2A-4j2uA:2.1 | 1yc2A-4j2uA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j2u | ENOYL-COA HYDRATASE (Rhodobactersphaeroides) |
PF16113(ECH_2) | 4 | ALA A 54SER A 18PHE A 60ILE A 34 | None | 0.95A | 1yc2A-4j2uA:2.1 | 1yc2A-4j2uA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6y | AMINOPEPTIDASE (Thermotogamaritima) |
PF05343(Peptidase_M42) | 4 | ALA A 204ASN A 43ILE A 45ASP A 39 | None | 1.02A | 1yc2A-4p6yA:undetectable | 1yc2A-4p6yA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pb6 | VP1 (Felinecalicivirus) |
PF00915(Calici_coat) | 4 | ALA A 300SER A 305ASN A 297ILE A 296 | None | 1.02A | 1yc2A-4pb6A:undetectable | 1yc2A-4pb6A:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qww | ACETYLCHOLINESTERASE (Bungarusfasciatus) |
PF00135(COesterase) | 4 | ALA A 164SER A 161PHE A 45ASP A 259 | None | 1.04A | 1yc2A-4qwwA:undetectable | 1yc2A-4qwwA:17.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r12 | PUTATIVEUNCHARACTERIZEDPROTEIN (Dictyosteliumpurpureum) |
PF05450(Nicastrin) | 4 | ALA A 380PHE A 390ILE A 448ASP A 447 | None | 0.89A | 1yc2A-4r12A:undetectable | 1yc2A-4r12A:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r1n | 3-HYDROXYBUTYRYL-COADEHYDROGENASE (Clostridiumbutyricum) |
PF00725(3HCDH)PF02737(3HCDH_N) | 4 | ALA A 256SER A 257ASN A 196ILE A 195 | None | 0.95A | 1yc2A-4r1nA:5.8 | 1yc2A-4r1nA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r5c | LEUCINE RICH REPEATPROTEIN (syntheticconstruct) |
PF12354(Internalin_N)PF12799(LRR_4)PF13516(LRR_6)PF13855(LRR_8) | 4 | ALA A 221PHE A 200ILE A 216ASP A 218 | NoneNoneNoneEDO A 401 (-3.9A) | 1.04A | 1yc2A-4r5cA:undetectable | 1yc2A-4r5cA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r8u | DNA POLYMERASE IV (Escherichiacoli) |
PF00817(IMS)PF11798(IMS_HHH)PF11799(IMS_C) | 4 | ALA B 106SER B 102PHE B 91ASP B 104 | NoneNoneNone MG B 402 ( 3.2A) | 0.99A | 1yc2A-4r8uB:undetectable | 1yc2A-4r8uB:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tv7 | HTH-TYPETRANSCRIPTIONALREGULATORY PROTEINGABR (Bacillussubtilis) |
PF00155(Aminotran_1_2)PF00392(GntR) | 4 | ALA A 269ASN A 303ILE A 276ASP A 299 | None | 0.83A | 1yc2A-4tv7A:3.2 | 1yc2A-4tv7A:22.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4twi | NAD-DEPENDENTPROTEIN DEACYLASE 1 (Archaeoglobusfulgidus) |
PF02146(SIR2) | 4 | ALA A 21SER A 24ASN A 99ASP A 101 | None | 0.15A | 1yc2A-4twiA:27.7 | 1yc2A-4twiA:47.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wd9 | NISIN BIOSYNTHESISPROTEIN NISB (Lactococcuslactis) |
PF04738(Lant_dehydr_N)PF14028(Lant_dehydr_C) | 4 | SER A 552ASN A 535ILE A 536ASP A 550 | None | 0.92A | 1yc2A-4wd9A:undetectable | 1yc2A-4wd9A:12.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8i | LYSYL AMINOPEPTIDASE (Pyrococcusfuriosus) |
PF05343(Peptidase_M42) | 4 | ALA A 214ASN A 46ILE A 48ASP A 42 | None | 0.97A | 1yc2A-4x8iA:undetectable | 1yc2A-4x8iA:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xri | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 4 | ALA A 472SER A 474ILE A 427ASP A 431 | None | 0.84A | 1yc2A-4xriA:undetectable | 1yc2A-4xriA:14.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4y6o | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 85SER A 88ASN A 168ILE A 169ASP A 170 | None | 0.29A | 1yc2A-4y6oA:20.1 | 1yc2A-4y6oA:30.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zzh | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 262SER A 265ASN A 346ILE A 347ASP A 348 | None | 0.29A | 1yc2A-4zzhA:23.3 | 1yc2A-4zzhA:27.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a3c | SIR2 FAMILY PROTEIN (Streptococcuspyogenes) |
no annotation | 4 | ALA A 34SER A 37ASN A 118ASP A 120 | NAD A1294 (-3.3A)NAD A1294 ( 4.1A)NAD A1294 (-3.9A)NAD A1294 (-3.9A) | 0.27A | 1yc2A-5a3cA:13.7 | 1yc2A-5a3cA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a3m | CEA1 (Komagataellapastoris) |
PF10528(GLEYA) | 4 | ALA A 207PHE A 89ASN A 202ASP A 137 | NoneNone CA A 500 (-3.0A)NAG A 501 ( 2.5A) | 1.00A | 1yc2A-5a3mA:undetectable | 1yc2A-5a3mA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a55 | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Streptococcuspneumoniae) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 4 | ALA A 580ASN A 579ILE A 591ASP A 588 | None CA A2419 (-3.0A)None CA A2419 (-2.2A) | 1.00A | 1yc2A-5a55A:undetectable | 1yc2A-5a55A:11.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bqm | SOMATOLIBERIN,BOTULINUM NEUROTOXIN TYPED (Clostridiumbotulinum;Homo sapiens) |
PF07952(Toxin_trans) | 4 | SER B 646PHE B 643ASN B 674ASP B 670 | None | 0.99A | 1yc2A-5bqmB:undetectable | 1yc2A-5bqmB:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bqn | BOTULINUM NEUROTOXINTYPE D,BOTULINUMNEUROTOXIN TYPE D (Clostridiumbotulinum) |
PF01742(Peptidase_M27)PF07952(Toxin_trans) | 4 | SER A 590PHE A 587ASN A 618ASP A 614 | None | 0.93A | 1yc2A-5bqnA:undetectable | 1yc2A-5bqnA:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5btr | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 262SER A 265ASN A 346ILE A 347ASP A 348 | None | 0.21A | 1yc2A-5btrA:23.7 | 1yc2A-5btrA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d6a | PREDICTED ATPASE OFTHE ABC CLASS (Vibriovulnificus) |
PF09818(ABC_ATPase) | 4 | ALA A 331SER A 332ILE A 258ASP A 273 | None | 1.01A | 1yc2A-5d6aA:undetectable | 1yc2A-5d6aA:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5feu | NOROXOMARITIDINE/NORCRAUGSODINEREDUCTASE (Narcissuspseudonarcissus) |
PF13561(adh_short_C2) | 4 | SER A 152PHE A 100ASN A 105ILE A 106 | None | 1.00A | 1yc2A-5feuA:4.4 | 1yc2A-5feuA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ff9 | NOROXOMARITIDINE/NORCRAUGSODINEREDUCTASE (Narcissuspseudonarcissus) |
PF13561(adh_short_C2) | 4 | SER A 152PHE A 100ASN A 105ILE A 106 | None | 1.01A | 1yc2A-5ff9A:4.0 | 1yc2A-5ff9A:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fyq | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 85SER A 88ASN A 168ILE A 169ASP A 170 | SO4 A1357 ( 4.1A)NoneNoneNoneNone | 0.23A | 1yc2A-5fyqA:20.1 | 1yc2A-5fyqA:26.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fyq | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-2 (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 85SER A 88PHE A 96ASN A 168ASP A 170 | SO4 A1357 ( 4.1A)NoneNoneNoneNone | 1.00A | 1yc2A-5fyqA:20.1 | 1yc2A-5fyqA:26.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gqr | LEUCINE-RICH REPEATRECEPTOR-LIKEPROTEIN KINASE TDR (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 4 | SER B 568PHE B 613ASN B 590ASP B 566 | None | 1.01A | 1yc2A-5gqrB:undetectable | 1yc2A-5gqrB:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ixq | RECEPTOR-LIKEPROTEIN KINASE 5 (Arabidopsisthaliana) |
PF08263(LRRNT_2)PF13855(LRR_8) | 4 | SER A 555PHE A 599ASN A 576ASP A 553 | NAG A 712 (-2.5A)NoneNAG A 712 (-1.8A)NAG A 712 ( 4.5A) | 0.95A | 1yc2A-5ixqA:undetectable | 1yc2A-5ixqA:16.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lp5 | RODSHAPE-DETERMININGPROTEIN (MREC) (Helicobacterpylori) |
PF04085(MreC) | 4 | ALA C 225SER C 224ILE C 170ASP C 181 | None | 1.04A | 1yc2A-5lp5C:undetectable | 1yc2A-5lp5C:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ndz | LYSOZYME,PROTEINASE-ACTIVATED RECEPTOR2,SOLUBLE CYTOCHROMEB562,PROTEINASE-ACTIVATED RECEPTOR 2 (Escherichiacoli;Homo sapiens;Escherichiavirus T4) |
PF00001(7tm_1)PF00959(Phage_lysozyme)PF07361(Cytochrom_B562) | 4 | SER A 162ASN A 336ILE A 339ASP A 340 | NA A2202 (-2.2A) NA A2202 (-3.4A)None NA A2202 (-3.3A) | 1.03A | 1yc2A-5ndzA:undetectable | 1yc2A-5ndzA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nth | PUTATIVEAMINOPEPTIDASE (Leishmaniamajor) |
PF00883(Peptidase_M17) | 4 | ALA A 363ASN A 362ILE A 301ASP A 304 | NoneNoneNone MN A 603 (-2.6A) | 1.04A | 1yc2A-5nthA:undetectable | 1yc2A-5nthA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ny0 | L. REUTERIS SRRPBINDING REGION (Lactobacillusreuteri) |
no annotation | 5 | ALA A 509SER A 483ASN A 486ILE A 487ASP A 451 | None | 1.26A | 1yc2A-5ny0A:undetectable | 1yc2A-5ny0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nz7 | CELLODEXTRINPHOSPHORYLASE (Ruminiclostridiumthermocellum) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 4 | ALA A 822SER A 819PHE A 753ILE A 845 | None | 1.03A | 1yc2A-5nz7A:undetectable | 1yc2A-5nz7A:13.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oj7 | NAD-DEPENDENTPROTEIN DEACYLASE (Xenopustropicalis) |
no annotation | 4 | ALA A 62SER A 65ASN A 143ASP A 145 | AR6 A 401 (-3.6A)NoneNoneNone | 0.30A | 1yc2A-5oj7A:24.5 | 1yc2A-5oj7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ol0 | PUTATIVE SILENTINFORMATIONREGULATOR 2,PUTATIVESILENT INFORMATIONREGULATOR 2 (Leishmaniainfantum) |
no annotation | 5 | ALA A 40SER A 43ASN A 125ILE A 126ASP A 127 | None | 0.23A | 1yc2A-5ol0A:20.7 | 1yc2A-5ol0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ol0 | PUTATIVE SILENTINFORMATIONREGULATOR 2,PUTATIVESILENT INFORMATIONREGULATOR 2 (Leishmaniainfantum) |
no annotation | 4 | SER A 43PHE A 51ILE A 126ASP A 127 | None | 0.74A | 1yc2A-5ol0A:20.7 | 1yc2A-5ol0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tqw | INHIBITOR OF NUCLEARFACTOR KAPPA-BKINASE SUBUNIT ALPHA (Homo sapiens) |
PF00069(Pkinase) | 4 | ALA A 189SER A 206ILE A 141ASP A 203 | None | 0.95A | 1yc2A-5tqwA:undetectable | 1yc2A-5tqwA:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ehn | CARBOHYDRATEESTERASE MZ0003 (unidentifiedprokaryoticorganism) |
no annotation | 4 | ALA A 94PHE A 86ILE A 176ASP A 96 | None | 0.97A | 1yc2A-6ehnA:undetectable | 1yc2A-6ehnA:undetectable | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6enx | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Danio rerio) |
no annotation | 4 | ALA A 55PHE A 66ASN A 137ILE A 138 | BJW A 303 (-3.5A)BJW A 303 (-3.6A)NoneBJW A 303 (-3.9A) | 0.72A | 1yc2A-6enxA:24.3 | 1yc2A-6enxA:40.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6enx | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Danio rerio) |
no annotation | 5 | ALA A 55SER A 58ASN A 137ILE A 138ASP A 139 | BJW A 303 (-3.5A)NoneNoneBJW A 303 (-3.9A)None | 0.31A | 1yc2A-6enxA:24.3 | 1yc2A-6enxA:40.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f6e | RIBONUCLEOTIDEREDUCTASE SMALLSUBUNIT (Geobacilluskaustophilus) |
no annotation | 4 | ALA A 63SER A 66PHE A 126ILE A 118 | None | 0.95A | 1yc2A-6f6eA:undetectable | 1yc2A-6f6eA:undetectable |