SIMILAR PATTERNS OF AMINO ACIDS FOR 1YC2_A_NCAA506

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ae1 TROPINONE
REDUCTASE-I


(Datura
stramonium)
PF13561
(adh_short_C2)
4 SER A 148
PHE A  96
ASN A 101
ILE A 102
None
1.01A 1yc2A-1ae1A:
5.0
1yc2A-1ae1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 ALA A  72
SER A  79
PHE A  93
ILE A  59
None
1.01A 1yc2A-1asoA:
undetectable
1yc2A-1asoA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea6 PMS1 PROTEIN HOMOLOG
2


(Homo sapiens)
PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3)
4 ALA A 196
SER A 220
ASN A 226
ILE A 227
None
0.78A 1yc2A-1ea6A:
undetectable
1yc2A-1ea6A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eke RIBONUCLEASE HII

(Methanocaldococcus
jannaschii)
PF01351
(RNase_HII)
4 ALA A 113
PHE A 121
ILE A   6
ASP A   7
None
1.04A 1yc2A-1ekeA:
undetectable
1yc2A-1ekeA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta)
PF02126
(PTE)
4 PHE A  72
ASN A 312
ILE A 313
ASP A 315
None
0.96A 1yc2A-1eywA:
undetectable
1yc2A-1eywA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 ALA A 466
SER A 463
ILE A 445
ASP A 441
None
0.90A 1yc2A-1g8kA:
3.1
1yc2A-1g8kA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34


(Pisum sativum)
PF04548
(AIG1)
4 SER A  81
PHE A  87
ASN A  90
ILE A  42
None
1.01A 1yc2A-1h65A:
undetectable
1yc2A-1h65A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1it2 HEMOGLOBIN

(Eptatretus
burgeri)
PF00042
(Globin)
4 ALA A  48
SER A  51
PHE A  45
ILE A 112
ALA  A  48 ( 0.0A)
SER  A  51 (-0.0A)
PHE  A  45 ( 1.3A)
ILE  A 112 ( 0.4A)
1.01A 1yc2A-1it2A:
undetectable
1yc2A-1it2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis)
PF12468
(TTSSLRR)
4 ALA A1304
SER A1285
ASN A1303
ASP A1283
None
0.97A 1yc2A-1jl5A:
undetectable
1yc2A-1jl5A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
4 ALA A2673
SER A2676
PHE A2646
ASP A2809
None
0.95A 1yc2A-1js8A:
undetectable
1yc2A-1js8A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT


(Klebsiella
pneumoniae)
PF08841
(DDR)
4 ALA A  17
SER A  31
ASN A 594
ILE A 586
None
0.88A 1yc2A-1nbwA:
3.7
1yc2A-1nbwA:
17.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q14 HST2 PROTEIN

(Saccharomyces
cerevisiae)
PF02146
(SIR2)
5 ALA A  33
SER A  36
ASN A 116
ILE A 117
ASP A 118
None
0.15A 1yc2A-1q14A:
19.2
1yc2A-1q14A:
30.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae)
PF02146
(SIR2)
6 ALA A  33
SER A  36
PHE A  44
ASN A 116
ILE A 117
ASP A 118
OAD  A1001 (-3.9A)
None
OAD  A1001 (-3.5A)
None
OAD  A1001 ( 4.4A)
None
0.70A 1yc2A-1q1aA:
20.4
1yc2A-1q1aA:
33.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus)
PF00028
(Cadherin)
4 ALA A 193
SER A 147
PHE A 108
ILE A 165
None
1.02A 1yc2A-1q5aA:
undetectable
1yc2A-1q5aA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A


(Homo sapiens)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C)
4 ALA A 348
SER A 345
ILE A 319
ASP A 322
None
1.04A 1yc2A-1r47A:
undetectable
1yc2A-1r47A:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s5p NAD-DEPENDENT
DEACETYLASE


(Escherichia
coli)
PF02146
(SIR2)
5 ALA A  49
SER A  52
ASN A 130
ILE A 131
ASP A 132
None
0.35A 1yc2A-1s5pA:
21.9
1yc2A-1s5pA:
39.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s7g NAD-DEPENDENT
DEACETYLASE 2


(Archaeoglobus
fulgidus)
PF02146
(SIR2)
5 ALA A  24
SER A  27
ASN A 101
ILE A 102
ASP A 103
NAD  A 703 (-3.8A)
None
None
None
None
0.14A 1yc2A-1s7gA:
42.4
1yc2A-1s7gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus)
PF00135
(COesterase)
4 ALA A 382
SER A 386
PHE A 379
ASP A 539
None
0.99A 1yc2A-1thgA:
undetectable
1yc2A-1thgA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens)
PF00069
(Pkinase)
4 ALA A 168
PHE A 165
ILE A 145
ASP A 202
None
0.97A 1yc2A-1tkiA:
undetectable
1yc2A-1tkiA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG


(Bacillus
subtilis)
PF05343
(Peptidase_M42)
4 ALA A 241
SER A 254
ILE A 295
ASP A 293
None
0.98A 1yc2A-1vheA:
undetectable
1yc2A-1vheA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpw LOC51668 PROTEIN

(Homo sapiens)
PF00754
(F5_F8_type_C)
4 ALA A 133
SER A 132
ILE A   4
ASP A   5
None
1.02A 1yc2A-1xpwA:
undetectable
1yc2A-1xpwA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT


(Klebsiella
oxytoca)
PF08841
(DDR)
4 ALA A  17
SER A  32
ASN A 592
ILE A 584
None
0.89A 1yc2A-2d0oA:
undetectable
1yc2A-2d0oA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4


(Homo sapiens)
PF00248
(Aldo_ket_red)
4 ALA A 269
SER A 271
ASN A 280
ILE A 281
NAP  A1001 ( 4.9A)
NAP  A1001 (-2.4A)
NAP  A1001 (-3.2A)
None
1.02A 1yc2A-2fvlA:
undetectable
1yc2A-2fvlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2


(Saccharomyces
cerevisiae)
PF02146
(SIR2)
PF04574
(DUF592)
6 ALA A 263
SER A 266
PHE A 274
ASN A 345
ILE A 346
ASP A 347
XYQ  A1222 (-3.4A)
None
NCA  A 900 ( 3.9A)
None
NCA  A 900 (-4.6A)
None
0.63A 1yc2A-2hjhA:
19.5
1yc2A-2hjhA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4v UNCHARACTERIZED
PROTEIN PA1076


(Pseudomonas
aeruginosa)
PF16703
(DUF5064)
4 PHE A  54
ASN A  24
ILE A  23
ASP A  22
None
0.95A 1yc2A-2k4vA:
undetectable
1yc2A-2k4vA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjp PYROPHOSPHATASE

(Methanocaldococcus
jannaschii)
PF01725
(Ham1p_like)
4 ALA A 150
SER A 153
ASN A  98
ILE A 101
None
0.92A 1yc2A-2mjpA:
undetectable
1yc2A-2mjpA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o14 HYPOTHETICAL PROTEIN
YXIM


(Bacillus
subtilis)
PF13472
(Lipase_GDSL_2)
4 ALA A  57
SER A  58
ASN A  97
ASP A 117
None
0.96A 1yc2A-2o14A:
undetectable
1yc2A-2o14A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 ALA A 500
ASN A 473
ILE A 471
ASP A 447
None
None
None
MG  A1001 ( 2.8A)
0.94A 1yc2A-2q27A:
13.6
1yc2A-2q27A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpq PROTEIN BUG27

(Bordetella
pertussis)
PF03401
(TctC)
4 ALA A 100
ASN A  98
ILE A  97
ASP A 273
None
1.03A 1yc2A-2qpqA:
undetectable
1yc2A-2qpqA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5j MAJOR CAPSID PROTEIN
L1


(Alphapapillomavirus
9)
PF00500
(Late_protein_L1)
4 ALA A 345
SER A 347
ASN A 357
ASP A 350
None
0.95A 1yc2A-2r5jA:
undetectable
1yc2A-2r5jA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbe BIPOLAR KINESIN
KRP-130


(Drosophila
melanogaster)
PF00225
(Kinesin)
4 SER C 112
ASN C 104
ILE C 119
ASP C 115
None
1.02A 1yc2A-2wbeC:
undetectable
1yc2A-2wbeC:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyr COBALT-ACTIVATED
PEPTIDASE TET1


(Pyrococcus
horikoshii)
PF05343
(Peptidase_M42)
4 ALA A 211
ASN A  44
ILE A  46
ASP A  40
None
1.00A 1yc2A-2wyrA:
undetectable
1yc2A-2wyrA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1


(Arabidopsis
thaliana)
PF07859
(Abhydrolase_3)
4 ALA A 262
PHE A 251
ASN A 199
ILE A 196
None
1.03A 1yc2A-2zsiA:
2.1
1yc2A-2zsiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brz TODX

(Pseudomonas
putida)
PF03349
(Toluene_X)
4 ALA A 237
SER A  21
ILE A 299
ASP A 298
None
1.01A 1yc2A-3brzA:
undetectable
1yc2A-3brzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5i CHOLINE KINASE

(Plasmodium
knowlesi)
PF01633
(Choline_kinase)
4 SER A 260
PHE A 339
ILE A 257
ASP A 258
None
None
CA  A 371 (-4.4A)
None
1.00A 1yc2A-3c5iA:
undetectable
1yc2A-3c5iA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN


(Bacteroides
fragilis)
PF14587
(Glyco_hydr_30_2)
4 SER A 242
ASN A 292
ILE A 250
ASP A 238
None
1.00A 1yc2A-3clwA:
undetectable
1yc2A-3clwA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e10 PUTATIVE NADH
OXIDASE


(Clostridium
acetobutylicum)
PF00881
(Nitroreductase)
4 PHE A 129
ASN A  52
ILE A  53
ASP A  49
EDO  A 503 (-4.0A)
EDO  A 503 (-3.4A)
None
None
0.99A 1yc2A-3e10A:
undetectable
1yc2A-3e10A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Streptococcus
pneumoniae)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
4 ALA A 580
ASN A 579
ILE A 591
ASP A 588
None
CA  A2000 (-2.8A)
None
CA  A2000 (-2.3A)
0.97A 1yc2A-3ecqA:
undetectable
1yc2A-3ecqA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek9 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 2


(Mus musculus)
PF00622
(SPRY)
4 SER A  74
ASN A  56
ILE A  57
ASP A  76
None
1.04A 1yc2A-3ek9A:
undetectable
1yc2A-3ek9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi8 CHOLINE KINASE

(Plasmodium
falciparum)
PF01633
(Choline_kinase)
4 SER A 330
PHE A 409
ILE A 327
ASP A 328
None
1.03A 1yc2A-3fi8A:
undetectable
1yc2A-3fi8A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb0 PEPTIDASE T

(Bacillus cereus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 ALA A 147
ASN A  57
ILE A  59
ASP A  45
None
1.03A 1yc2A-3gb0A:
undetectable
1yc2A-3gb0A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE


(Escherichia
coli)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase)
4 ALA A 441
SER A 439
PHE A 343
ILE A 464
None
0.99A 1yc2A-3gmeA:
undetectable
1yc2A-3gmeA:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jr3 NAD-DEPENDENT
DEACETYLASE


(Thermotoga
maritima)
PF02146
(SIR2)
5 ALA A  22
SER A  25
ASN A  99
ILE A 100
ASP A 101
None
0.23A 1yc2A-3jr3A:
26.9
1yc2A-3jr3A:
42.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll9 ISOPENTENYL
PHOSPHATE KINASE


(Methanothermobacter
thermautotrophicus)
PF00696
(AA_kinase)
4 ALA A 243
ASN A  25
ILE A  11
ASP A  22
None
0.77A 1yc2A-3ll9A:
2.9
1yc2A-3ll9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6


(Homo sapiens)
PF02146
(SIR2)
5 ALA A  51
SER A  54
PHE A  62
ASN A 112
ASP A 114
A2N  A1000 (-3.5A)
None
A2N  A1000 (-3.8A)
None
None
0.71A 1yc2A-3pkjA:
22.7
1yc2A-3pkjA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2


(Rattus
norvegicus)
PF01070
(FMN_dh)
4 ALA A 257
SER A 258
ASN A  37
ILE A  38
None
1.02A 1yc2A-3sgzA:
undetectable
1yc2A-3sgzA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE


(Mycobacterium
ulcerans)
PF00106
(adh_short)
5 ALA A  14
SER A  15
PHE A  52
ASN A  87
ILE A  37
None
1.36A 1yc2A-3tl3A:
5.0
1yc2A-3tl3A:
24.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6


(Homo sapiens)
PF02146
(SIR2)
5 ALA A  51
SER A  54
PHE A  62
ASN A 112
ASP A 114
APR  A1296 (-3.7A)
None
APR  A1296 (-3.6A)
None
None
0.73A 1yc2A-3zg6A:
21.7
1yc2A-3zg6A:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq2 HOMOGENTISATE
1,2-DIOXYGENASE


(Pseudomonas
putida)
PF04209
(HgmA)
4 ALA A 118
SER A 404
PHE A 338
ILE A 133
None
0.88A 1yc2A-4aq2A:
undetectable
1yc2A-4aq2A:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL


(Homo sapiens)
PF02146
(SIR2)
5 ALA A 146
SER A 149
ASN A 229
ILE A 230
ASP A 231
CNA  A1395 (-3.1A)
CNA  A1395 (-4.3A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
0.40A 1yc2A-4bn5A:
20.9
1yc2A-4bn5A:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de8 CPS2A

(Streptococcus
pneumoniae)
PF02916
(DNA_PPF)
PF03816
(LytR_cpsA_psr)
4 ALA A 267
SER A 245
ASN A 248
ILE A 249
None
0.90A 1yc2A-4de8A:
undetectable
1yc2A-4de8A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus)
PF00303
(Thymidylat_synt)
4 ALA A 223
PHE A 258
ASN A 232
ILE A 233
UMP  A 501 (-4.2A)
None
UMP  A 501 (-2.7A)
None
1.00A 1yc2A-4dq1A:
undetectable
1yc2A-4dq1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN


(Rhizobium etli)
PF01408
(GFO_IDH_MocA)
4 SER A 229
PHE A 220
ILE A 232
ASP A 231
None
1.03A 1yc2A-4ew6A:
5.2
1yc2A-4ew6A:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL


(Homo sapiens)
PF02146
(SIR2)
6 ALA A  59
SER A  62
PHE A  70
ASN A 141
ILE A 142
ASP A 143
CNA  A 402 (-3.0A)
CNA  A 402 ( 4.1A)
CNA  A 402 (-3.2A)
CNA  A 402 (-4.1A)
CNA  A 402 (-4.7A)
CNA  A 402 (-3.7A)
0.88A 1yc2A-4g1cA:
25.4
1yc2A-4g1cA:
39.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2


(Saccharomyces
cerevisiae)
PF02146
(SIR2)
PF04574
(DUF592)
5 ALA A 263
SER A 266
ASN A 345
ILE A 346
ASP A 347
APR  A 602 (-3.3A)
None
None
None
None
0.26A 1yc2A-4iaoA:
23.8
1yc2A-4iaoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2


(Saccharomyces
cerevisiae)
PF02146
(SIR2)
PF04574
(DUF592)
5 ALA A 263
SER A 266
PHE A 274
ASN A 345
ILE A 346
APR  A 602 (-3.3A)
None
APR  A 602 (-3.5A)
None
None
0.71A 1yc2A-4iaoA:
23.8
1yc2A-4iaoA:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1


(Homo sapiens)
PF02146
(SIR2)
5 ALA A 262
SER A 265
ASN A 346
ILE A 347
ASP A 348
None
0.24A 1yc2A-4ig9A:
23.8
1yc2A-4ig9A:
32.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN


(Ruegeria sp.
TM1040)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ALA A  34
ASN A  58
ILE A  62
ASP A  11
None
0.97A 1yc2A-4ip4A:
undetectable
1yc2A-4ip4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides)
PF16113
(ECH_2)
4 ALA A  54
SER A  18
PHE A  60
ILE A  15
None
1.01A 1yc2A-4j2uA:
2.1
1yc2A-4j2uA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides)
PF16113
(ECH_2)
4 ALA A  54
SER A  18
PHE A  60
ILE A  34
None
0.95A 1yc2A-4j2uA:
2.1
1yc2A-4j2uA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6y AMINOPEPTIDASE

(Thermotoga
maritima)
PF05343
(Peptidase_M42)
4 ALA A 204
ASN A  43
ILE A  45
ASP A  39
None
1.02A 1yc2A-4p6yA:
undetectable
1yc2A-4p6yA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb6 VP1

(Feline
calicivirus)
PF00915
(Calici_coat)
4 ALA A 300
SER A 305
ASN A 297
ILE A 296
None
1.02A 1yc2A-4pb6A:
undetectable
1yc2A-4pb6A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus)
PF00135
(COesterase)
4 ALA A 164
SER A 161
PHE A  45
ASP A 259
None
1.04A 1yc2A-4qwwA:
undetectable
1yc2A-4qwwA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Dictyostelium
purpureum)
PF05450
(Nicastrin)
4 ALA A 380
PHE A 390
ILE A 448
ASP A 447
None
0.89A 1yc2A-4r12A:
undetectable
1yc2A-4r12A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1n 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE


(Clostridium
butyricum)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
4 ALA A 256
SER A 257
ASN A 196
ILE A 195
None
0.95A 1yc2A-4r1nA:
5.8
1yc2A-4r1nA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN


(synthetic
construct)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 ALA A 221
PHE A 200
ILE A 216
ASP A 218
None
None
None
EDO  A 401 (-3.9A)
1.04A 1yc2A-4r5cA:
undetectable
1yc2A-4r5cA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8u DNA POLYMERASE IV

(Escherichia
coli)
PF00817
(IMS)
PF11798
(IMS_HHH)
PF11799
(IMS_C)
4 ALA B 106
SER B 102
PHE B  91
ASP B 104
None
None
None
MG  B 402 ( 3.2A)
0.99A 1yc2A-4r8uB:
undetectable
1yc2A-4r8uB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR


(Bacillus
subtilis)
PF00155
(Aminotran_1_2)
PF00392
(GntR)
4 ALA A 269
ASN A 303
ILE A 276
ASP A 299
None
0.83A 1yc2A-4tv7A:
3.2
1yc2A-4tv7A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1


(Archaeoglobus
fulgidus)
PF02146
(SIR2)
4 ALA A  21
SER A  24
ASN A  99
ASP A 101
None
0.15A 1yc2A-4twiA:
27.7
1yc2A-4twiA:
47.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB


(Lactococcus
lactis)
PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C)
4 SER A 552
ASN A 535
ILE A 536
ASP A 550
None
0.92A 1yc2A-4wd9A:
undetectable
1yc2A-4wd9A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8i LYSYL AMINOPEPTIDASE

(Pyrococcus
furiosus)
PF05343
(Peptidase_M42)
4 ALA A 214
ASN A  46
ILE A  48
ASP A  42
None
0.97A 1yc2A-4x8iA:
undetectable
1yc2A-4x8iA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
4 ALA A 472
SER A 474
ILE A 427
ASP A 431
None
0.84A 1yc2A-4xriA:
undetectable
1yc2A-4xriA:
14.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2


(Homo sapiens)
PF02146
(SIR2)
5 ALA A  85
SER A  88
ASN A 168
ILE A 169
ASP A 170
None
0.29A 1yc2A-4y6oA:
20.1
1yc2A-4y6oA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1


(Homo sapiens)
PF02146
(SIR2)
5 ALA A 262
SER A 265
ASN A 346
ILE A 347
ASP A 348
None
0.29A 1yc2A-4zzhA:
23.3
1yc2A-4zzhA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3c SIR2 FAMILY PROTEIN

(Streptococcus
pyogenes)
no annotation 4 ALA A  34
SER A  37
ASN A 118
ASP A 120
NAD  A1294 (-3.3A)
NAD  A1294 ( 4.1A)
NAD  A1294 (-3.9A)
NAD  A1294 (-3.9A)
0.27A 1yc2A-5a3cA:
13.7
1yc2A-5a3cA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3m CEA1

(Komagataella
pastoris)
PF10528
(GLEYA)
4 ALA A 207
PHE A  89
ASN A 202
ASP A 137
None
None
CA  A 500 (-3.0A)
NAG  A 501 ( 2.5A)
1.00A 1yc2A-5a3mA:
undetectable
1yc2A-5a3mA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Streptococcus
pneumoniae)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
4 ALA A 580
ASN A 579
ILE A 591
ASP A 588
None
CA  A2419 (-3.0A)
None
CA  A2419 (-2.2A)
1.00A 1yc2A-5a55A:
undetectable
1yc2A-5a55A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqm SOMATOLIBERIN,BOTULI
NUM NEUROTOXIN TYPE
D


(Clostridium
botulinum;
Homo sapiens)
PF07952
(Toxin_trans)
4 SER B 646
PHE B 643
ASN B 674
ASP B 670
None
0.99A 1yc2A-5bqmB:
undetectable
1yc2A-5bqmB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqn BOTULINUM NEUROTOXIN
TYPE D,BOTULINUM
NEUROTOXIN TYPE D


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07952
(Toxin_trans)
4 SER A 590
PHE A 587
ASN A 618
ASP A 614
None
0.93A 1yc2A-5bqnA:
undetectable
1yc2A-5bqnA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1


(Homo sapiens)
PF02146
(SIR2)
5 ALA A 262
SER A 265
ASN A 346
ILE A 347
ASP A 348
None
0.21A 1yc2A-5btrA:
23.7
1yc2A-5btrA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS


(Vibrio
vulnificus)
PF09818
(ABC_ATPase)
4 ALA A 331
SER A 332
ILE A 258
ASP A 273
None
1.01A 1yc2A-5d6aA:
undetectable
1yc2A-5d6aA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5feu NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE


(Narcissus
pseudonarcissus)
PF13561
(adh_short_C2)
4 SER A 152
PHE A 100
ASN A 105
ILE A 106
None
1.00A 1yc2A-5feuA:
4.4
1yc2A-5feuA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE


(Narcissus
pseudonarcissus)
PF13561
(adh_short_C2)
4 SER A 152
PHE A 100
ASN A 105
ILE A 106
None
1.01A 1yc2A-5ff9A:
4.0
1yc2A-5ff9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2


(Homo sapiens)
PF02146
(SIR2)
5 ALA A  85
SER A  88
ASN A 168
ILE A 169
ASP A 170
SO4  A1357 ( 4.1A)
None
None
None
None
0.23A 1yc2A-5fyqA:
20.1
1yc2A-5fyqA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2


(Homo sapiens)
PF02146
(SIR2)
5 ALA A  85
SER A  88
PHE A  96
ASN A 168
ASP A 170
SO4  A1357 ( 4.1A)
None
None
None
None
1.00A 1yc2A-5fyqA:
20.1
1yc2A-5fyqA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
4 SER B 568
PHE B 613
ASN B 590
ASP B 566
None
1.01A 1yc2A-5gqrB:
undetectable
1yc2A-5gqrB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5


(Arabidopsis
thaliana)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
4 SER A 555
PHE A 599
ASN A 576
ASP A 553
NAG  A 712 (-2.5A)
None
NAG  A 712 (-1.8A)
NAG  A 712 ( 4.5A)
0.95A 1yc2A-5ixqA:
undetectable
1yc2A-5ixqA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)


(Helicobacter
pylori)
PF04085
(MreC)
4 ALA C 225
SER C 224
ILE C 170
ASP C 181
None
1.04A 1yc2A-5lp5C:
undetectable
1yc2A-5lp5C:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndz LYSOZYME,PROTEINASE-
ACTIVATED RECEPTOR
2,SOLUBLE CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2


(Escherichia
coli;
Homo sapiens;
Escherichia
virus T4)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF07361
(Cytochrom_B562)
4 SER A 162
ASN A 336
ILE A 339
ASP A 340
NA  A2202 (-2.2A)
NA  A2202 (-3.4A)
None
NA  A2202 (-3.3A)
1.03A 1yc2A-5ndzA:
undetectable
1yc2A-5ndzA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nth PUTATIVE
AMINOPEPTIDASE


(Leishmania
major)
PF00883
(Peptidase_M17)
4 ALA A 363
ASN A 362
ILE A 301
ASP A 304
None
None
None
MN  A 603 (-2.6A)
1.04A 1yc2A-5nthA:
undetectable
1yc2A-5nthA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION


(Lactobacillus
reuteri)
no annotation 5 ALA A 509
SER A 483
ASN A 486
ILE A 487
ASP A 451
None
1.26A 1yc2A-5ny0A:
undetectable
1yc2A-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE


(Ruminiclostridium
thermocellum)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
4 ALA A 822
SER A 819
PHE A 753
ILE A 845
None
1.03A 1yc2A-5nz7A:
undetectable
1yc2A-5nz7A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE


(Xenopus
tropicalis)
no annotation 4 ALA A  62
SER A  65
ASN A 143
ASP A 145
AR6  A 401 (-3.6A)
None
None
None
0.30A 1yc2A-5oj7A:
24.5
1yc2A-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2


(Leishmania
infantum)
no annotation 5 ALA A  40
SER A  43
ASN A 125
ILE A 126
ASP A 127
None
0.23A 1yc2A-5ol0A:
20.7
1yc2A-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2


(Leishmania
infantum)
no annotation 4 SER A  43
PHE A  51
ILE A 126
ASP A 127
None
0.74A 1yc2A-5ol0A:
20.7
1yc2A-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA


(Homo sapiens)
PF00069
(Pkinase)
4 ALA A 189
SER A 206
ILE A 141
ASP A 203
None
0.95A 1yc2A-5tqwA:
undetectable
1yc2A-5tqwA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehn CARBOHYDRATE
ESTERASE MZ0003


(unidentified
prokaryotic
organism)
no annotation 4 ALA A  94
PHE A  86
ILE A 176
ASP A  96
None
0.97A 1yc2A-6ehnA:
undetectable
1yc2A-6ehnA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6enx NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL


(Danio rerio)
no annotation 4 ALA A  55
PHE A  66
ASN A 137
ILE A 138
BJW  A 303 (-3.5A)
BJW  A 303 (-3.6A)
None
BJW  A 303 (-3.9A)
0.72A 1yc2A-6enxA:
24.3
1yc2A-6enxA:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6enx NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL


(Danio rerio)
no annotation 5 ALA A  55
SER A  58
ASN A 137
ILE A 138
ASP A 139
BJW  A 303 (-3.5A)
None
None
BJW  A 303 (-3.9A)
None
0.31A 1yc2A-6enxA:
24.3
1yc2A-6enxA:
40.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f6e RIBONUCLEOTIDE
REDUCTASE SMALL
SUBUNIT


(Geobacillus
kaustophilus)
no annotation 4 ALA A  63
SER A  66
PHE A 126
ILE A 118
None
0.95A 1yc2A-6f6eA:
undetectable
1yc2A-6f6eA:
undetectable