SIMILAR PATTERNS OF AMINO ACIDS FOR 1YAT_A_FK5A108

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eom ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F3


(Elizabethkingia
meningoseptica)
PF00704
(Glyco_hydro_18)
5 ASP A  34
VAL A 284
ILE A 271
TYR A 274
ILE A  29
None
1.34A 1yatA-1eomA:
undetectable
1yatA-1eomA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)


(Legionella
pneumophila)
PF00254
(FKBP_C)
PF01346
(FKBP_N)
6 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.13A 1yatA-1fd9A:
18.2
1yatA-1fd9A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)


(Legionella
pneumophila)
PF00254
(FKBP_C)
PF01346
(FKBP_N)
8 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.59A 1yatA-1fd9A:
18.2
1yatA-1fd9A:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN


(Bos taurus)
PF00254
(FKBP_C)
10 TYR A  26
ASP A  37
ARG A  42
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
ILE A  91
PHE A  99
None
0.50A 1yatA-1fkkA:
20.6
1yatA-1fkkA:
57.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4s RIBONUCLEASE III

(Aquifex
aeolicus)
PF14622
(Ribonucleas_3_3)
5 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
None
1.35A 1yatA-1i4sA:
undetectable
1yatA-1i4sA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR


(Trypanosoma
cruzi)
PF00254
(FKBP_C)
6 PHE A 114
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
None
0.97A 1yatA-1jvwA:
16.8
1yatA-1jvwA:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR


(Trypanosoma
cruzi)
PF00254
(FKBP_C)
8 TYR A  92
ARG A 108
VAL A 119
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
None
0.46A 1yatA-1jvwA:
16.8
1yatA-1jvwA:
32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR


(Trypanosoma
cruzi)
PF00254
(FKBP_C)
8 TYR A  92
ASP A 103
ARG A 108
ILE A 120
TRP A 123
TYR A 146
ILE A 155
PHE A 163
None
0.62A 1yatA-1jvwA:
16.8
1yatA-1jvwA:
32.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51


(Saimiri
boliviensis)
PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8)
7 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
None
0.86A 1yatA-1kt1A:
16.9
1yatA-1kt1A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51


(Saimiri
boliviensis)
PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8)
6 TYR A  57
PHE A  77
VAL A  86
TRP A  90
TYR A 113
ILE A 122
None
1.49A 1yatA-1kt1A:
16.9
1yatA-1kt1A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md7 C1R COMPLEMENT
SERINE PROTEASE


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
5 TYR A 568
PHE A 567
VAL A 643
ILE A 656
PHE A 621
None
1.14A 1yatA-1md7A:
undetectable
1yatA-1md7A:
16.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens)
PF00254
(FKBP_C)
9 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
None
0.54A 1yatA-1n1aA:
19.7
1yatA-1n1aA:
39.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pbk FKBP25

(Homo sapiens)
PF00254
(FKBP_C)
8 TYR A 135
ASP A 146
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 208
PHE A 216
RAP  A 225 (-3.9A)
RAP  A 225 (-3.0A)
RAP  A 225 (-3.5A)
RAP  A 225 (-3.9A)
RAP  A 225 (-3.4A)
RAP  A 225 (-4.6A)
RAP  A 225 ( 4.9A)
None
0.29A 1yatA-1pbkA:
19.4
1yatA-1pbkA:
40.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA


(Escherichia
coli)
PF00254
(FKBP_C)
PF01346
(FKBP_N)
6 PHE A 168
ILE A 174
TRP A 177
TYR A 200
ILE A 208
PHE A 216
None
1.31A 1yatA-1q6hA:
18.2
1yatA-1q6hA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA


(Escherichia
coli)
PF00254
(FKBP_C)
PF01346
(FKBP_N)
9 TYR A 146
ASP A 157
ARG A 162
VAL A 173
ILE A 174
TRP A 177
TYR A 200
ILE A 208
PHE A 216
None
0.55A 1yatA-1q6hA:
18.2
1yatA-1q6hA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY


(Caenorhabditis
elegans)
PF00254
(FKBP_C)
10 TYR A  40
ASP A  51
ARG A  56
PHE A  60
VAL A  69
ILE A  70
TRP A  73
TYR A  96
ILE A 105
PHE A 113
None
0.61A 1yatA-1r9hA:
21.7
1yatA-1r9hA:
42.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc7 RIBONUCLEASE III

(Aquifex
aeolicus)
PF00035
(dsrm)
PF14622
(Ribonucleas_3_3)
5 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
None
1.28A 1yatA-1rc7A:
undetectable
1yatA-1rc7A:
15.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3


(Arabidopsis
thaliana)
PF00254
(FKBP_C)
8 ASP A  48
VAL A  66
ILE A  67
TRP A  70
TYR A  99
LEU A 112
ILE A 113
PHE A 121
None
0.76A 1yatA-1u79A:
19.3
1yatA-1u79A:
44.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3


(Arabidopsis
thaliana)
PF00254
(FKBP_C)
8 TYR A  37
ASP A  48
VAL A  66
ILE A  67
TRP A  70
TYR A  99
ILE A 113
PHE A 121
None
0.43A 1yatA-1u79A:
19.3
1yatA-1u79A:
44.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 OUTER CAPSID PROTEIN
P8


(Rice dwarf
virus)
no annotation 5 PHE P 414
ILE P 100
TYR P  80
LEU P  82
PHE P  71
None
1.23A 1yatA-1uf2P:
undetectable
1yatA-1uf2P:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN


(Pyrococcus
horikoshii)
PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C)
5 PHE A 307
VAL A 220
LEU A  18
ILE A  21
PHE A 294
None
1.27A 1yatA-1wu2A:
undetectable
1yatA-1wu2A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykd ADENYLATE CYCLASE

(Anabaena sp.)
PF01590
(GAF)
5 PHE A 228
VAL A 195
ILE A 106
LEU A 237
ILE A 238
None
1.29A 1yatA-1ykdA:
undetectable
1yatA-1ykdA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6


(Homo sapiens)
PF00017
(SH2)
PF00102
(Y_phosphatase)
5 VAL A 451
ILE A 450
LEU A 395
ILE A 409
PHE A 335
None
1.35A 1yatA-2b3oA:
undetectable
1yatA-2b3oA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbe HYPOTHETICAL PROTEIN
SO0527


(Shewanella
oneidensis)
PF03992
(ABM)
5 TYR A  86
PHE A  87
TYR A  50
LEU A  52
ILE A  38
None
1.25A 1yatA-2bbeA:
undetectable
1yatA-2bbeA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER


(Bacillus
subtilis)
PF07470
(Glyco_hydro_88)
5 TYR A 285
ASP A 224
ARG A  52
TYR A 295
ILE A 226
None
1.25A 1yatA-2gh4A:
undetectable
1yatA-2gh4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjg GTP-BINDING PROTEIN
ENGA


(Bacillus
subtilis)
PF01926
(MMR_HSR1)
PF14714
(KH_dom-like)
5 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
None
1.26A 1yatA-2hjgA:
undetectable
1yatA-2hjgA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iue INTEGRIN BETA-2-LIKE
PROTEIN


(Mus musculus)
PF00362
(Integrin_beta)
5 TYR A 179
PHE A 116
VAL A 153
ILE A 186
LEU A 108
None
1.21A 1yatA-2iueA:
undetectable
1yatA-2iueA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Aedes aegypti)
PF00254
(FKBP_C)
5 TYR A  27
PHE A  47
ILE A  57
TRP A  60
ILE A  92
None
1.07A 1yatA-2lpvA:
17.8
1yatA-2lpvA:
51.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lpv FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Aedes aegypti)
PF00254
(FKBP_C)
5 TYR A  27
VAL A  56
ILE A  57
TRP A  60
ILE A  92
None
1.04A 1yatA-2lpvA:
17.8
1yatA-2lpvA:
51.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2my5 PEPTIDYL CARRIER
PROTEIN


(Micromonospora
sp. TP-A0468)
PF00550
(PP-binding)
5 PHE A  15
VAL A  35
LEU A  48
ILE A  45
PHE A  66
None
1.32A 1yatA-2my5A:
undetectable
1yatA-2my5A:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2


(Homo sapiens)
PF00254
(FKBP_C)
9 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
TYR A 112
ILE A 121
PHE A 129
PEG  A 201 (-4.4A)
None
PEG  A 201 ( 3.9A)
PEG  A 201 (-3.6A)
PEG  A 201 (-3.8A)
PEG  A 201 (-3.7A)
None
None
None
0.71A 1yatA-2pbcA:
16.4
1yatA-2pbcA:
45.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP


(Legionella
pneumophila)
PF00254
(FKBP_C)
PF01346
(FKBP_N)
5 ASP A  66
VAL A  82
ILE A  83
TRP A  86
PHE A 126
RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 ( 4.7A)
0.76A 1yatA-2vcdA:
15.0
1yatA-2vcdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vcd OUTER MEMBRANE
PROTEIN MIP


(Legionella
pneumophila)
PF00254
(FKBP_C)
PF01346
(FKBP_N)
6 TYR A  55
ASP A  66
VAL A  82
ILE A  83
TRP A  86
TYR A 109
RAP  A 138 (-2.6A)
RAP  A 138 (-2.7A)
RAP  A 138 (-3.2A)
RAP  A 138 (-3.6A)
RAP  A 138 (-2.3A)
RAP  A 138 (-3.8A)
0.83A 1yatA-2vcdA:
15.0
1yatA-2vcdA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE


(Plasmodium
falciparum)
PF00254
(FKBP_C)
10 TYR A  44
ASP A  56
ARG A  61
PHE A  65
VAL A  74
ILE A  75
TRP A  78
TYR A 101
ILE A 110
PHE A 118
FK5  A 501 (-4.1A)
FK5  A 501 (-3.4A)
FK5  A 501 (-3.9A)
FK5  A 501 (-4.1A)
FK5  A 501 (-3.5A)
FK5  A 501 (-4.3A)
FK5  A 501 (-3.3A)
FK5  A 501 (-4.7A)
None
FK5  A 501 (-4.8A)
0.28A 1yatA-2vn1A:
20.8
1yatA-2vn1A:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Burkholderia
pseudomallei)
PF00254
(FKBP_C)
10 TYR A  33
ASP A  44
ARG A  49
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
None
0.65A 1yatA-2y78A:
20.4
1yatA-2y78A:
45.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b7x FK506-BINDING
PROTEIN 6


(Homo sapiens)
PF00254
(FKBP_C)
5 TYR A  61
ASP A  73
TYR A 118
ILE A 127
PHE A 135
None
0.90A 1yatA-3b7xA:
16.1
1yatA-3b7xA:
31.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foc TRYPTOPHANYL-TRNA
SYNTHETASE


(Giardia
intestinalis)
PF00579
(tRNA-synt_1b)
5 ASP A 208
ARG A 214
PHE A 212
VAL A 106
TYR A 155
None
1.21A 1yatA-3focA:
undetectable
1yatA-3focA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzg 16S RRNA METHYLASE

(Escherichia
coli)
PF07091
(FmrO)
5 PHE A 177
ILE A 157
TYR A 159
LEU A 146
ILE A 150
None
1.35A 1yatA-3fzgA:
undetectable
1yatA-3fzgA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2t BASEPLATE STRUCTURAL
PROTEIN GP6


(Escherichia
virus T4)
no annotation 5 VAL A 541
ILE A 540
LEU A 611
ILE A 606
PHE A 515
None
1.00A 1yatA-3h2tA:
undetectable
1yatA-3h2tA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyj PROTEIN DUF199/WHIA

(Thermotoga
maritima)
PF10298
(WhiA_N)
PF14527
(LAGLIDADG_WhiA)
5 PHE A 155
VAL A 112
ILE A 185
LEU A 170
ILE A 136
None
1.35A 1yatA-3hyjA:
undetectable
1yatA-3hyjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9f PUTATIVE TYPE 11
METHYLTRANSFERASE


(Sulfolobus
solfataricus)
PF08241
(Methyltransf_11)
5 TYR A 147
ASP A 126
PHE A 151
VAL A 122
ILE A 123
None
1.33A 1yatA-3i9fA:
undetectable
1yatA-3i9fA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
9 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
None
0.80A 1yatA-3o5dA:
20.4
1yatA-3o5dA:
23.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
8 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TYR A 113
ILE A 122
PHE A 130
None
0.76A 1yatA-3o5eA:
20.4
1yatA-3o5eA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
7 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
None
0.85A 1yatA-3o5eA:
20.4
1yatA-3o5eA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE


(Plasmodium
vivax)
PF00254
(FKBP_C)
10 TYR A  43
ASP A  55
ARG A  60
PHE A  64
VAL A  73
ILE A  74
TRP A  77
TYR A 100
ILE A 109
PHE A 117
None
0.63A 1yatA-3pa7A:
20.6
1yatA-3pa7A:
39.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6


(Homo sapiens)
PF00017
(SH2)
PF00102
(Y_phosphatase)
5 VAL A 451
ILE A 450
LEU A 395
ILE A 409
PHE A 335
None
1.35A 1yatA-3ps5A:
undetectable
1yatA-3ps5A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE


(Plasmodium
falciparum)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 TYR A 569
VAL A 210
ILE A 224
TYR A 226
ILE A 200
None
1.19A 1yatA-3um6A:
undetectable
1yatA-3um6A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C)
5 ILE B 573
TRP B 591
TYR B 569
LEU B 697
PHE B 535
None
1.29A 1yatA-3v0aB:
undetectable
1yatA-3v0aB:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wia NITRITE REDUCTASE

(Geobacillus
kaustophilus)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 VAL A 278
ILE A 232
LEU A 307
ILE A 291
PHE A 250
None
1.22A 1yatA-3wiaA:
undetectable
1yatA-3wiaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkq NITRITE REDUCTASE

(Geobacillus
thermodenitrificans)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 VAL A 278
ILE A 232
LEU A 307
ILE A 291
PHE A 250
None
1.22A 1yatA-3wkqA:
undetectable
1yatA-3wkqA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1


(Saccharomyces
cerevisiae)
PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N)
5 PHE A 258
VAL A 290
ILE A 291
LEU A 352
ILE A 349
None
1.15A 1yatA-4b8bA:
undetectable
1yatA-4b8bA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1


(Saccharomyces
cerevisiae)
PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N)
5 PHE A 258
VAL A 290
LEU A 352
ILE A 349
PHE A 282
None
1.12A 1yatA-4b8bA:
undetectable
1yatA-4b8bA:
11.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae)
PF00254
(FKBP_C)
7 ASP A 324
VAL A 341
ILE A 342
TRP A 345
TYR A 368
ILE A 376
PHE A 384
None
0.78A 1yatA-4bf8A:
18.5
1yatA-4bf8A:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae)
PF00254
(FKBP_C)
5 TYR A 313
ASP A 324
PHE A 332
TRP A 345
PHE A 384
None
1.04A 1yatA-4bf8A:
18.5
1yatA-4bf8A:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae)
PF00254
(FKBP_C)
7 TYR A 313
ASP A 324
VAL A 341
ILE A 342
TRP A 345
TYR A 368
PHE A 384
None
0.82A 1yatA-4bf8A:
18.5
1yatA-4bf8A:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum)
PF04054
(Not1)
5 TYR A2111
ASP A2075
ARG A2059
PHE A2069
ILE A2119
None
1.12A 1yatA-4c0eA:
undetectable
1yatA-4c0eA:
10.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dip PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14


(Homo sapiens)
PF00254
(FKBP_C)
5 TYR A  52
TRP A  88
TYR A 111
ILE A 119
PHE A 127
None
0.52A 1yatA-4dipA:
17.6
1yatA-4dipA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dz3 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Burkholderia
pseudomallei)
PF00254
(FKBP_C)
10 TYR A  33
ASP A  44
ARG A  49
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
FK5  A 201 ( 3.9A)
FK5  A 201 (-3.5A)
FK5  A 201 ( 3.7A)
FK5  A 201 (-4.1A)
FK5  A 201 ( 3.6A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.7A)
None
FK5  A 201 (-4.8A)
0.32A 1yatA-4dz3A:
21.2
1yatA-4dz3A:
51.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN


(Eubacterium
ventriosum)
PF13306
(LRR_5)
5 PHE A 337
VAL A 346
ILE A 369
ILE A 375
PHE A 383
None
1.25A 1yatA-4h09A:
undetectable
1yatA-4h09A:
19.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B


(Homo sapiens)
PF00254
(FKBP_C)
7 TYR A  26
ASP A  37
ARG A  42
ILE A  56
TYR A  82
ILE A  91
PHE A  99
None
0.68A 1yatA-4iqcA:
20.3
1yatA-4iqcA:
57.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B


(Homo sapiens)
PF00254
(FKBP_C)
7 TYR A  26
PHE A  46
VAL A  55
ILE A  56
TYR A  82
ILE A  91
PHE A  99
None
0.76A 1yatA-4iqcA:
20.3
1yatA-4iqcA:
57.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4


(Homo sapiens)
PF00254
(FKBP_C)
9 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
None
DMS  A 304 (-4.3A)
0.74A 1yatA-4lawA:
20.8
1yatA-4lawA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4


(Homo sapiens)
PF00254
(FKBP_C)
9 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
ILE A 122
PHE A 130
None
None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 ( 4.0A)
None
DMS  A 304 (-4.3A)
0.80A 1yatA-4lawA:
20.8
1yatA-4lawA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmw GLUTATHIONE
TRANSFERASE


(Phanerochaete
chrysosporium)
PF13417
(GST_N_3)
5 ARG A 104
PHE A 106
ILE A  91
LEU A  37
ILE A   6
None
None
None
FMT  A 308 ( 4.4A)
FMT  A 308 ( 4.7A)
1.13A 1yatA-4lmwA:
undetectable
1yatA-4lmwA:
16.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4msp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14


(Homo sapiens)
PF00254
(FKBP_C)
PF13499
(EF-hand_7)
5 TYR A  33
TRP A  69
TYR A  92
ILE A 100
PHE A 108
None
0.51A 1yatA-4mspA:
18.0
1yatA-4mspA:
32.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2


(Homo sapiens)
PF00254
(FKBP_C)
9 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TRP A  89
TYR A 112
ILE A 121
PHE A 129
FK5  A 201 (-4.1A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.0A)
FK5  A 201 (-3.4A)
FK5  A 201 (-3.8A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.5A)
None
FK5  A 201 (-4.9A)
0.18A 1yatA-4nnrA:
16.6
1yatA-4nnrA:
40.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD


(Thermus
thermophilus)
PF00254
(FKBP_C)
5 TYR A  13
ASP A  23
ILE A  37
TYR A  63
PHE A 128
None
0.51A 1yatA-4odmA:
11.7
1yatA-4odmA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA


(Homo sapiens;
Thermus
thermophilus)
PF00254
(FKBP_C)
6 TYR A  13
ASP A  23
ILE A  37
TYR A  63
ILE A  72
PHE A  80
FK5  A 201 ( 3.6A)
FK5  A 201 (-3.6A)
FK5  A 201 (-3.9A)
FK5  A 201 (-4.4A)
None
FK5  A 201 ( 4.8A)
0.37A 1yatA-4odrA:
13.5
1yatA-4odrA:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B CATALYTIC
SUBUNIT


(Saccharomyces
cerevisiae)
PF00583
(Acetyltransf_1)
PF10394
(Hat1_N)
5 VAL A  24
ILE A  23
TYR A 226
ILE A 188
PHE A  63
None
1.17A 1yatA-4pswA:
undetectable
1yatA-4pswA:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
8 TYR A  57
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
PHE A 130
None
0.76A 1yatA-4r0xA:
20.9
1yatA-4r0xA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
8 TYR A  57
ASP A  68
ARG A  73
PHE A  77
VAL A  86
ILE A  87
TYR A 113
PHE A 130
None
0.83A 1yatA-4r0xA:
20.9
1yatA-4r0xA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
8 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TYR A 113
ILE A 122
PHE A 130
None
0.82A 1yatA-4r0xA:
20.9
1yatA-4r0xA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5


(Homo sapiens)
PF00254
(FKBP_C)
8 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TRP A  90
TYR A 113
ILE A 122
PHE A 130
None
0.72A 1yatA-4r0xA:
20.9
1yatA-4r0xA:
44.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305


(Thermoplasma
acidophilum)
no annotation 5 ASP A 234
ARG A 204
ILE A  37
LEU A 230
ILE A 227
None
1.30A 1yatA-4rkzA:
undetectable
1yatA-4rkzA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN


(Saccharophagus
degradans)
PF15979
(Glyco_hydro_115)
5 ASP A 944
PHE A 845
ILE A 840
TYR A 459
ILE A 883
None
1.17A 1yatA-4zmhA:
undetectable
1yatA-4zmhA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9


(Francisella
tularensis)
no annotation 5 PHE A1576
VAL A1561
ILE A1547
TYR A1549
ILE A1611
None
1.19A 1yatA-5b2oA:
undetectable
1yatA-5b2oA:
5.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Coccidioides
immitis)
PF00254
(FKBP_C)
11 TYR C  36
ASP C  56
ARG C  61
PHE C  64
VAL C  73
ILE C  74
TRP C  77
TYR C 100
LEU C 108
ILE C 109
PHE C 117
FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.4A)
FK5  C 201 (-4.5A)
None
None
FK5  C 201 (-4.7A)
0.51A 1yatA-5b8iC:
19.7
1yatA-5b8iC:
45.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 NEQ263
V-TYPE ATP SYNTHASE
ALPHA CHAIN


(Nanoarchaeum
equitans)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
5 ARG A 335
VAL B  31
ILE B  30
LEU B 235
ILE B 200
None
1.00A 1yatA-5bn4A:
undetectable
1yatA-5bn4A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE


(Microbispora
corallina)
PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C)
5 ASP A1034
PHE A 947
VAL A 954
ILE A 957
LEU A1030
None
1.34A 1yatA-5ehkA:
undetectable
1yatA-5ehkA:
5.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A


(Escherichia
coli;
Homo sapiens)
PF00254
(FKBP_C)
9 TYR A  26
ASP A  37
ARG A  42
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
PHE A 146
None
0.59A 1yatA-5i7pA:
18.7
1yatA-5i7pA:
39.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A


(Escherichia
coli;
Homo sapiens)
PF00254
(FKBP_C)
9 TYR A  26
ASP A  37
ARG A  42
PHE A  46
VAL A  55
ILE A  56
TRP A  59
TYR A  82
PHE A 147
None
0.59A 1yatA-5i7qA:
18.9
1yatA-5i7qA:
41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1


(Candida
albicans)
PF00254
(FKBP_C)
9 TYR A  30
ASP A  41
ARG A  46
PHE A  50
VAL A  59
ILE A  60
TRP A  63
TYR A  97
ILE A 102
None
1.26A 1yatA-5i98A:
19.9
1yatA-5i98A:
55.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1


(Candida
albicans)
PF00254
(FKBP_C)
10 TYR A  30
ASP A  41
ARG A  46
PHE A  50
VAL A  59
ILE A  60
TRP A  63
TYR A  97
ILE A 106
PHE A 114
None
0.58A 1yatA-5i98A:
19.9
1yatA-5i98A:
55.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j6e FK506-BINDING
PROTEIN 1A


(Aspergillus
fumigatus)
PF00254
(FKBP_C)
10 TYR A  27
ASP A  38
ARG A  43
PHE A  47
VAL A  56
ILE A  57
TRP A  60
TYR A  83
ILE A  92
PHE A 100
None
0.60A 1yatA-5j6eA:
21.0
1yatA-5j6eA:
61.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcv LMO2181 PROTEIN

(Listeria
monocytogenes)
PF04203
(Sortase)
5 ASP A 125
VAL A  75
ILE A  89
TYR A 161
ILE A 221
None
1.05A 1yatA-5jcvA:
undetectable
1yatA-5jcvA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila)
PF00128
(Alpha-amylase)
5 ASP B 213
VAL B 195
ILE B 198
TYR B  88
ILE B  85
EDO  B 616 ( 2.8A)
None
None
None
None
1.31A 1yatA-5m99B:
undetectable
1yatA-5m99B:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msz THERMOBIA DOMESTICA
DOMESTICA AA15


(Thermobia
domestica)
no annotation 5 ASP A  84
VAL A  72
ILE A 190
TYR A  75
ILE A  81
None
1.19A 1yatA-5mszA:
undetectable
1yatA-5mszA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msz THERMOBIA DOMESTICA
DOMESTICA AA15


(Thermobia
domestica)
no annotation 5 PHE A 114
VAL A 155
ILE A 190
LEU A 143
ILE A  81
None
1.22A 1yatA-5mszA:
undetectable
1yatA-5mszA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae)
no annotation 10 TYR A  33
ASP A  44
ARG A  49
PHE A  53
VAL A  62
ILE A  63
TRP A  66
TYR A  89
ILE A  98
PHE A 106
8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.6A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.6A)
8ZV  A 201 (-4.0A)
8ZV  A 201 (-3.3A)
8ZV  A 201 (-4.6A)
8ZV  A 201 ( 4.8A)
8ZV  A 201 (-4.6A)
0.39A 1yatA-5v8tA:
21.2
1yatA-5v8tA:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Pseudomonas
syringae group
genomosp. 3)
PF00254
(FKBP_C)
7 PHE A 166
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 207
PHE A 215
TLA  A 301 ( 4.6A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
None
1.01A 1yatA-5xb0A:
17.5
1yatA-5xb0A:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Pseudomonas
syringae group
genomosp. 3)
PF00254
(FKBP_C)
8 TYR A 147
ASP A 158
VAL A 171
ILE A 172
TRP A 175
TYR A 198
ILE A 207
PHE A 215
TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
None
0.65A 1yatA-5xb0A:
17.5
1yatA-5xb0A:
32.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0y SERINE
HYDROXYMETHYLTRANSFE
RASE


(Komagataella
phaffii)
no annotation 5 TYR A 339
ASP A 418
VAL A 393
ILE A 395
PHE A 334
None
1.32A 1yatA-5z0yA:
undetectable
1yatA-5z0yA:
20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE


(Naegleria
fowleri)
no annotation 7 TYR A  38
ASP A  49
ARG A  54
ILE A  68
TYR A  94
LEU A 102
ILE A  99
None
1.50A 1yatA-6b4pA:
21.2
1yatA-6b4pA:
48.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE


(Naegleria
fowleri)
no annotation 8 TYR A  38
ASP A  49
ARG A  54
ILE A  68
TYR A  94
LEU A 102
ILE A 103
PHE A 111
None
0.56A 1yatA-6b4pA:
21.2
1yatA-6b4pA:
48.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE


(Naegleria
fowleri)
no annotation 9 TYR A  38
ASP A  49
ARG A  54
PHE A  58
VAL A  67
ILE A  68
TRP A  71
TYR A  94
ILE A  99
None
1.45A 1yatA-6b4pA:
21.2
1yatA-6b4pA:
48.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE


(Naegleria
fowleri)
no annotation 10 TYR A  38
ASP A  49
ARG A  54
PHE A  58
VAL A  67
ILE A  68
TRP A  71
TYR A  94
ILE A 103
PHE A 111
None
0.62A 1yatA-6b4pA:
21.2
1yatA-6b4pA:
48.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8


(Homo sapiens)
no annotation 5 TYR A 344
ASP A  84
ARG A 355
VAL A 402
ILE A 406
None
1.22A 1yatA-6bszA:
undetectable
1yatA-6bszA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1


(Homo sapiens)
no annotation 5 PHE C 724
VAL C 687
ILE C 690
LEU C 707
ILE C 704
None
1.30A 1yatA-6en4C:
undetectable
1yatA-6en4C:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA


(Trypanosoma
brucei)
no annotation 5 VAL D 145
ILE D 146
TYR D 152
LEU D 334
ILE D 158
None
1.31A 1yatA-6f5dD:
undetectable
1yatA-6f5dD:
22.81