SIMILAR PATTERNS OF AMINO ACIDS FOR 1YAJ_K_BEZK4387

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		3 TRP A 337
LEU A 402
LYS A 223
 None
None
ADP  A 421 (-2.7A)
 1.32A 1yajK-13pkA:
undetectable		 1yajK-13pkA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3c PROTEIN (NEUROTOXIN
CSE-I)

(Centruroides
sculpturatus) 		PF00537
(Toxin_3) 		3 TRP A  30
LEU A   5
LYS A  13
 None
 1.44A 1yajK-1b3cA:
undetectable		 1yajK-1b3cA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE

(Escherichia
coli) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		3 TRP A 303
LEU A 301
LYS A 250
 None
 1.27A 1yajK-1i8tA:
undetectable		 1yajK-1i8tA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		3 TRP A 208
LEU A  20
LYS A  22
 None
 1.26A 1yajK-1jjiA:
18.5		 1yajK-1jjiA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00632
(HECT) 		3 TRP A 883
LEU A 884
LYS A 908
 None
 1.45A 1yajK-1nd7A:
undetectable		 1yajK-1nd7A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrv HIGH MOBILITY GROUP
PROTEIN D

(Drosophila
melanogaster) 		PF00505
(HMG_box) 		3 TRP A  15
LEU A  14
LYS A  55
 None
 1.31A 1yajK-1qrvA:
undetectable		 1yajK-1qrvA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		3 TRP A 316
LEU A 243
LYS A   2
 None
 1.01A 1yajK-1rkxA:
3.6		 1yajK-1rkxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		3 TRP A 431
LEU A 342
LYS A 337
 None
 1.42A 1yajK-1sqjA:
undetectable		 1yajK-1sqjA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 TRP X 205
LEU X 261
LYS X 222
 None
 1.22A 1yajK-1u8xX:
undetectable		 1yajK-1u8xX:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp5 TOPOISOMERASE IV

(Geobacillus
stearothermophilus) 		PF03989
(DNA_gyraseA_C) 		3 TRP A 303
LEU A  41
LYS A 310
 None
 1.44A 1yajK-1wp5A:
undetectable		 1yajK-1wp5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		3 TRP A 299
LEU A 301
LYS A 666
 None
 1.37A 1yajK-1x9dA:
undetectable		 1yajK-1x9dA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5z HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00271
(Helicase_C) 		3 TRP A 828
LEU A 855
LYS A 732
 None
 1.02A 1yajK-1z5zA:
undetectable		 1yajK-1z5zA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z63 HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		3 TRP A 828
LEU A 855
LYS A 732
 None
 0.95A 1yajK-1z63A:
undetectable		 1yajK-1z63A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zx5 MANNOSEPHOSPHATE
ISOMERASE, PUTATIVE

(Archaeoglobus
fulgidus) 		PF01238
(PMI_typeI) 		3 TRP A  39
LEU A  14
LYS A  28
 None
None
ACY  A 503 (-2.7A)
 1.29A 1yajK-1zx5A:
undetectable		 1yajK-1zx5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2d N-ACETYLGALACTOSAMIN
E KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 TRP A 262
LEU A 260
LYS A 274
 None
 1.19A 1yajK-2a2dA:
undetectable		 1yajK-2a2dA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bc0 NADH OXIDASE

(Streptococcus
pyogenes) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 TRP A  49
LEU A 155
LYS A 182
 None
 1.45A 1yajK-2bc0A:
undetectable		 1yajK-2bc0A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		3 TRP A  18
LEU A 161
LYS A 376
 None
 1.29A 1yajK-2eaeA:
undetectable		 1yajK-2eaeA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		3 TRP X 121
LEU X 114
LYS X 182
 None
 1.21A 1yajK-2f6hX:
undetectable		 1yajK-2f6hX:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE

(Pyrococcus
horikoshii) 		PF16363
(GDP_Man_Dehyd) 		3 TRP A 294
LEU A 292
LYS A 233
 None
 1.46A 1yajK-2hunA:
3.1		 1yajK-2hunA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hv2 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 TRP A 185
LEU A 187
LYS A 166
 None
 1.36A 1yajK-2hv2A:
undetectable		 1yajK-2hv2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 TRP A 607
LEU A 627
LYS A 615
 None
 1.23A 1yajK-2ipcA:
0.0		 1yajK-2ipcA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 TRP A 820
LEU A 822
LYS A 341
 None
 0.87A 1yajK-2ivfA:
undetectable		 1yajK-2ivfA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw0 CHITIN DEACETYLASE

(Colletotrichum
lindemuthianum) 		PF01522
(Polysacc_deac_1) 		3 TRP A 245
LEU A 238
LYS A  29
 None
 1.28A 1yajK-2iw0A:
undetectable		 1yajK-2iw0A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1b GTP-BINDING NUCLEAR
PROTEIN RAN

(Homo sapiens) 		PF00071
(Ras) 		3 TRP A  64
LEU A  15
LYS A  23
 None
 1.39A 1yajK-2n1bA:
2.4		 1yajK-2n1bA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0y HYPOTHETICAL PROTEIN
LP_0780

(Lactobacillus
plantarum) 		PF01933
(UPF0052) 		3 TRP A 167
LEU A 138
LYS A 176
 None
 1.02A 1yajK-2p0yA:
3.1		 1yajK-2p0yA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4h VESTITONE REDUCTASE

(Medicago sativa) 		PF01370
(Epimerase) 		3 TRP X 148
LEU X 143
LYS X 140
 None
 1.10A 1yajK-2p4hX:
4.2		 1yajK-2p4hX:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		3 TRP A 159
LEU A 181
LYS A 173
 None
 1.26A 1yajK-2pgeA:
undetectable		 1yajK-2pgeA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		3 TRP A 381
LEU A 258
LYS A  27
 None
 1.49A 1yajK-2pq6A:
undetectable		 1yajK-2pq6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		3 TRP A  80
LEU A  77
LYS A 161
 None
 1.12A 1yajK-2ps3A:
undetectable		 1yajK-2ps3A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD

(Lactobacillus
paracasei) 		PF04909
(Amidohydro_2) 		3 TRP A 360
LEU A  13
LYS A 333
 None
 1.36A 1yajK-2qpxA:
undetectable		 1yajK-2qpxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4i UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF14534
(DUF4440) 		3 TRP A 111
LEU A  29
LYS A  13
 IPA  A 125 (-3.5A)
None
None
 1.39A 1yajK-2r4iA:
undetectable		 1yajK-2r4iA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82

(Saccharomyces
cerevisiae) 		no annotation 3 TRP B 269
LEU B 254
LYS B 342
 None
 1.33A 1yajK-2vduB:
undetectable		 1yajK-2vduB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh3 SPD1 NUCLEASE

(Streptococcus
pyogenes) 		PF13930
(Endonuclea_NS_2) 		3 TRP A 143
LEU A 232
LYS A 219
 None
 1.38A 1yajK-2xh3A:
undetectable		 1yajK-2xh3A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 TRP A 413
LEU A 410
LYS A 366
 None
 1.23A 1yajK-2xt6A:
2.1		 1yajK-2xt6A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN

(Salmonella
enterica) 		PF01297
(ZnuA) 		3 TRP A  80
LEU A  77
LYS A 165
 None
 1.41A 1yajK-2xy4A:
2.6		 1yajK-2xy4A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybq METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00590
(TP_methylase) 		3 TRP A  38
LEU A  40
LYS A  13
 None
 1.48A 1yajK-2ybqA:
undetectable		 1yajK-2ybqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Corynebacterium
glutamicum) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		3 TRP A 246
LEU A 303
LYS A 488
 None
 0.94A 1yajK-2zciA:
undetectable		 1yajK-2zciA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT ALPHA

(Rhodococcus
erythropolis) 		PF02979
(NHase_alpha) 		3 TRP A 117
LEU A 120
LYS A 192
 None
 1.19A 1yajK-2zpbA:
undetectable		 1yajK-2zpbA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw9 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Pyrobaculum
calidifontis) 		PF01370
(Epimerase) 		3 TRP A 285
LEU A 210
LYS A  19
 None
 0.88A 1yajK-3aw9A:
2.4		 1yajK-3aw9A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE

(Histophilus
somni) 		PF00834
(Ribul_P_3_epim) 		3 TRP A 212
LEU A 213
LYS A 204
 None
 0.88A 1yajK-3cu2A:
2.0		 1yajK-3cu2A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dur ANTIBODY FV FRAGMENT
SAG173-04

(Mus musculus) 		PF07686
(V-set) 		3 TRP A  50
LEU A  33
LYS A  89
 None
 1.30A 1yajK-3durA:
undetectable		 1yajK-3durA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehe UDP-GLUCOSE
4-EPIMERASE (GALE-1)

(Archaeoglobus
fulgidus) 		PF01370
(Epimerase) 		3 TRP A 282
LEU A 215
LYS A  20
 None
 1.32A 1yajK-3eheA:
2.1		 1yajK-3eheA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		3 TRP A 342
LEU A 344
LYS A 358
 None
 1.38A 1yajK-3ewdA:
undetectable		 1yajK-3ewdA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzy RTX TOXIN RTXA

(Vibrio cholerae) 		PF11713
(Peptidase_C80) 		3 TRP A3633
LEU A3592
LYS A3559
 UNX  A 323 (-3.9A)
None
None
 1.19A 1yajK-3fzyA:
undetectable		 1yajK-3fzyA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE

(Trichormus
variabilis) 		PF13649
(Methyltransf_25) 		3 TRP A  18
LEU A 110
LYS A 140
 SAH  A 248 (-3.7A)
SAH  A 248 ( 4.2A)
CL  A 247 (-3.2A)
 1.36A 1yajK-3ggdA:
undetectable		 1yajK-3ggdA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 3 TRP A 845
LEU A 735
LYS A 971
 None
 1.35A 1yajK-3j3iA:
undetectable		 1yajK-3j3iA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		3 TRP A 830
LEU A 833
LYS A 838
 None
 1.14A 1yajK-3jbhA:
undetectable		 1yajK-3jbhA:
14.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		3 TRP A1357
LEU A1418
LYS A1414
 None
 1.24A 1yajK-3k9bA:
61.0		 1yajK-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m70 TELLURITE RESISTANCE
PROTEIN TEHB HOMOLOG

(Haemophilus
influenzae) 		PF03848
(TehB)
PF09313
(DUF1971) 		3 TRP A 148
LEU A 158
LYS A 162
 None
 1.00A 1yajK-3m70A:
undetectable		 1yajK-3m70A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7h PUTIDACIN L1

(Pseudomonas
putida) 		PF01453
(B_lectin) 		3 TRP A 218
LEU A 217
LYS A 194
 None
 1.11A 1yajK-3m7hA:
undetectable		 1yajK-3m7hA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		3 TRP A 319
LEU A 329
LYS A  87
 None
 1.34A 1yajK-3o7wA:
2.5		 1yajK-3o7wA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opw DNA
DAMAGE-RESPONSIVE
TRANSCRIPTIONAL
REPRESSOR RPH1

(Saccharomyces
cerevisiae) 		PF02373
(JmjC)
PF02375
(JmjN) 		3 TRP A 199
LEU A 196
LYS A  55
 None
 1.48A 1yajK-3opwA:
undetectable		 1yajK-3opwA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 TRP B   7
LEU B   6
LYS B 152
 None
 1.40A 1yajK-3pcoB:
undetectable		 1yajK-3pcoB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		3 TRP A 503
LEU A 500
LYS A 661
 None
 1.43A 1yajK-3qcwA:
undetectable		 1yajK-3qcwA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz1 STEROID
21-HYDROXYLASE

(Bos taurus) 		PF00067
(p450) 		3 TRP A 117
LEU A 110
LYS A  99
 HEM  A 500 (-4.4A)
3QZ  A 501 (-4.3A)
None
 1.39A 1yajK-3qz1A:
undetectable		 1yajK-3qz1A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3soe MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		no annotation 3 TRP A 634
LEU A 630
LYS A 700
 None
 1.35A 1yajK-3soeA:
undetectable		 1yajK-3soeA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 TRP A 365
LEU A 561
LYS A 279
 None
 1.41A 1yajK-3sunA:
0.7		 1yajK-3sunA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sw0 COMPLEMENT FACTOR H

(Homo sapiens) 		PF00084
(Sushi) 		3 TRP X1183
LEU X1181
LYS X1188
 None
 1.48A 1yajK-3sw0X:
undetectable		 1yajK-3sw0X:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2c FRUCTOSE-1,6-BISPHOS
PHATE
ALDOLASE/PHOSPHATASE

(Pyrobaculum
neutrophilum) 		PF01950
(FBPase_3) 		3 TRP A  74
LEU A  72
LYS A  32
 None
 1.17A 1yajK-3t2cA:
undetectable		 1yajK-3t2cA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		3 TRP A 144
LEU A 161
LYS A 113
 None
None
NDP  A 262 (-3.1A)
 1.48A 1yajK-3u4cA:
4.4		 1yajK-3u4cA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN

(Clostridioides
difficile) 		PF01408
(GFO_IDH_MocA) 		3 TRP A 174
LEU A 173
LYS A 292
 GOL  A 310 ( 4.2A)
None
None
 1.31A 1yajK-3uuwA:
undetectable		 1yajK-3uuwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcn MANNONATE
DEHYDRATASE

(Caulobacter
vibrioides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 204
LEU A 202
LYS A 140
 None
 1.41A 1yajK-3vcnA:
undetectable		 1yajK-3vcnA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zw6 RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE 1,
CHLOROPLASTIC

(Nicotiana
tabacum) 		PF00004
(AAA) 		3 TRP A 109
LEU A 106
LYS A  85
 None
 1.42A 1yajK-3zw6A:
undetectable		 1yajK-3zw6A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn) 		3 TRP A 278
LEU A 280
LYS A  84
 None
 1.35A 1yajK-4a9aA:
undetectable		 1yajK-4a9aA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		3 TRP A  28
LEU A  58
LYS A 113
 None
 1.19A 1yajK-4dcmA:
undetectable		 1yajK-4dcmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14

(Kluyveromyces
lactis) 		PF05843
(Suf) 		3 TRP A 250
LEU A 246
LYS A 298
 None
 1.40A 1yajK-4ebaA:
undetectable		 1yajK-4ebaA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00046
(Homeobox)
PF13416
(SBP_bac_8)
PF16878
(SIX1_SD) 		3 TRP A 405
LEU A 404
LYS A 423
 None
 1.37A 1yajK-4egcA:
undetectable		 1yajK-4egcA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ekd GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(Q) SUBUNIT
ALPHA

(Mus musculus) 		PF00503
(G-alpha) 		3 TRP A 263
LEU A  43
LYS A  41
 None
 1.40A 1yajK-4ekdA:
2.6		 1yajK-4ekdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		3 TRP B 834
LEU B 835
LYS B 845
 None
 1.47A 1yajK-4fhnB:
2.1		 1yajK-4fhnB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		3 TRP M 834
LEU M 835
LYS M 845
 None
 1.44A 1yajK-4gq2M:
3.6		 1yajK-4gq2M:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE

(Solanum
tuberosum) 		PF00332
(Glyco_hydro_17) 		3 TRP A 262
LEU A 272
LYS A 332
 None
 0.77A 1yajK-4gziA:
undetectable		 1yajK-4gziA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhu 9C2 TCR DELTA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP D  32
LEU D  96
LYS D   5
 None
 1.44A 1yajK-4lhuD:
undetectable		 1yajK-4lhuD:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE

(Naegleria
gruberi) 		no annotation 3 TRP A  90
LEU A  85
LYS A  59
 None
 1.35A 1yajK-4lt5A:
undetectable		 1yajK-4lt5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1q L-LACTATE
DEHYDROGENASE

([Bacillus]
selenitireducens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TRP A 185
LEU A 182
LYS A 298
 None
 1.13A 1yajK-4m1qA:
undetectable		 1yajK-4m1qA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 TRP B 413
LEU B 394
LYS B 398
 None
 1.31A 1yajK-4ouaB:
undetectable		 1yajK-4ouaB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Sulfurospirillum
deleyianum) 		PF03480
(DctP) 		3 TRP A 141
LEU A 235
LYS A 127
 None
 1.33A 1yajK-4ovsA:
undetectable		 1yajK-4ovsA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6u UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 3 TRP A 169
LEU A  24
LYS A  26
 None
 1.22A 1yajK-4q6uA:
undetectable		 1yajK-4q6uA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 TRP A 560
LEU A 559
LYS A 239
 None
 1.31A 1yajK-4rf7A:
undetectable		 1yajK-4rf7A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnm IMPORTIN SUBUNIT
ALPHA

(Arabidopsis
thaliana) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		3 TRP A 379
LEU A 338
LYS A 347
 None
 0.94A 1yajK-4tnmA:
undetectable		 1yajK-4tnmA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3a ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		3 TRP A 155
LEU A 157
LYS A 198
 None
 1.21A 1yajK-4u3aA:
undetectable		 1yajK-4u3aA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1r ALPHA-1,6-MANNANASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		3 TRP A 248
LEU A 246
LYS A 300
 None
 1.41A 1yajK-4v1rA:
undetectable		 1yajK-4v1rA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkb YCF53-LIKE PROTEIN

(Synechocystis
sp. PCC 6803) 		PF05419
(GUN4)
PF16416
(GUN4_N) 		3 TRP A 167
LEU A 166
LYS A 180
 None
 1.47A 1yajK-4xkbA:
undetectable		 1yajK-4xkbA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		3 TRP A 649
LEU A 646
LYS A 661
 XYL  A2015 ( 4.7A)
None
None
 1.46A 1yajK-4xwhA:
undetectable		 1yajK-4xwhA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		3 TRP A 115
LEU A 108
LYS A 249
 None
 1.47A 1yajK-4yshA:
undetectable		 1yajK-4yshA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzt CELLULOSE HYDROLASE

(Bacillus
licheniformis) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 TRP A 100
LEU A 102
LYS A 148
 None
 1.18A 1yajK-4yztA:
2.2		 1yajK-4yztA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0n PROTEIN F2 LIKE
FIBRONECTIN-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		no annotation 3 TRP A 240
LEU A 244
LYS A  99
 None
 1.39A 1yajK-5a0nA:
undetectable		 1yajK-5a0nA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg9 TET-LIKE DIOXYGENASE

(Naegleria
gruberi) 		no annotation 3 TRP A  90
LEU A  85
LYS A  59
 None
 1.39A 1yajK-5cg9A:
undetectable		 1yajK-5cg9A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE

(Streptomyces
coelicolor) 		no annotation 3 TRP A 164
LEU A 166
LYS A  94
 None
None
MG  A 401 ( 4.1A)
 1.46A 1yajK-5dz2A:
0.4		 1yajK-5dz2A:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		3 TRP A 339
LEU A 349
LYS A 395
 None
 0.94A 1yajK-5fv4A:
64.8		 1yajK-5fv4A:
78.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		3 TRP A 339
LEU A 399
LYS A 395
 None
 1.38A 1yajK-5fv4A:
64.8		 1yajK-5fv4A:
78.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 TRP A 172
LEU A 125
LYS A  50
 None
 1.33A 1yajK-5gj8A:
undetectable		 1yajK-5gj8A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 TRP A 503
LEU A 539
LYS A 247
 None
 1.48A 1yajK-5jp0A:
undetectable		 1yajK-5jp0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE

(Homo sapiens) 		PF05118
(Asp_Arg_Hydrox)
PF13181
(TPR_8)
PF13432
(TPR_16) 		3 TRP A 576
LEU A 717
LYS A 709
 None
 1.20A 1yajK-5jz8A:
undetectable		 1yajK-5jz8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 3 TRP A 105
LEU A 473
LYS A 240
 None
 1.18A 1yajK-5nd1A:
undetectable		 1yajK-5nd1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF13561
(adh_short_C2) 		3 TRP A 248
LEU A 249
LYS A 144
 None
 1.08A 1yajK-5va8A:
2.7		 1yajK-5va8A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
ambifaria) 		PF13561
(adh_short_C2) 		3 TRP A 248
LEU A 182
LYS A 144
 None
 1.43A 1yajK-5vpsA:
2.6		 1yajK-5vpsA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
ambifaria) 		PF13561
(adh_short_C2) 		3 TRP A 248
LEU A 249
LYS A 144
 None
 1.03A 1yajK-5vpsA:
2.6		 1yajK-5vpsA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 3 TRP A 374
LEU A 375
LYS A 490
 None
 1.39A 1yajK-5wp4A:
undetectable		 1yajK-5wp4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2o TASTE RECEPTOR, TYPE
1, MEMBER 3

(Oryzias latipes) 		PF01094
(ANF_receptor) 		3 TRP B 410
LEU B 400
LYS B 420
 None
 0.90A 1yajK-5x2oB:
3.4		 1yajK-5x2oB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN

(Xanthomonas
campestris) 		no annotation 3 TRP A 328
LEU A 330
LYS A  63
 None
 1.34A 1yajK-6ei3A:
undetectable		 1yajK-6ei3A:
22.51