SIMILAR PATTERNS OF AMINO ACIDS FOR 1YAJ_J_BEZJ5041_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A

(Abrus
precatorius) 		PF00161
(RIP) 		4 GLY A 204
SER A 208
ILE A  33
HIS A  34
 None
 1.14A 1yajJ-1abrA:
undetectable		 1yajJ-1abrA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		4 GLY A  75
SER A 176
ILE A 385
HIS A 448
 None
 1.37A 1yajJ-1ac5A:
9.3		 1yajJ-1ac5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		4 GLY A  76
SER A 176
ILE A 385
HIS A 448
 None
 0.84A 1yajJ-1ac5A:
9.3		 1yajJ-1ac5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		4 GLY A  36
SER A 110
ILE A 237
HIS A 263
 None
 1.27A 1yajJ-1c4xA:
13.5		 1yajJ-1c4xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpy SERINE
CARBOXYPEPTIDASE

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		4 GLY A  52
SER A 146
ILE A 340
HIS A 397
 None
 1.33A 1yajJ-1cpyA:
8.9		 1yajJ-1cpyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpy SERINE
CARBOXYPEPTIDASE

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		4 GLY A  53
SER A 146
ILE A 340
HIS A 397
 None
 1.02A 1yajJ-1cpyA:
8.9		 1yajJ-1cpyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		4 GLY A 299
SER A 319
ILE A 296
HIS A 317
 None
 1.29A 1yajJ-1fw8A:
0.7		 1yajJ-1fw8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdi PHOSPHOGLYCERATE
KINASE

(Sus scrofa) 		PF00162
(PGK) 		4 GLY A 372
SER A 392
ILE A 369
HIS A 390
 None
 1.14A 1yajJ-1hdiA:
undetectable		 1yajJ-1hdiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkh GAMMA LACTAMASE

(Microbacterium) 		PF00561
(Abhydrolase_1) 		4 GLY A  31
SER A  98
ILE A 232
HIS A 259
 None
 1.24A 1yajJ-1hkhA:
12.3		 1yajJ-1hkhA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		4 GLY A 127
SER A 202
ILE A 260
HIS A 338
 None
 0.66A 1yajJ-1jkmA:
15.8		 1yajJ-1jkmA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		4 GLY A 128
SER A 202
ILE A 260
HIS A 338
 None
 1.02A 1yajJ-1jkmA:
15.8		 1yajJ-1jkmA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmo HEPARIN COFACTOR II

(Homo sapiens) 		PF00079
(Serpin) 		4 GLY A 144
SER A 147
ILE A 176
HIS A 159
 None
 1.21A 1yajJ-1jmoA:
undetectable		 1yajJ-1jmoA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 GLY A 918
SER A 965
ILE A 994
HIS A 746
 None
 1.10A 1yajJ-1k32A:
undetectable		 1yajJ-1k32A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n11 ANKYRIN

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 GLY A 767
SER A 764
ILE A 773
HIS A 739
 None
 1.10A 1yajJ-1n11A:
undetectable		 1yajJ-1n11A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0w RIBONUCLEASE III

(Thermotoga
maritima) 		PF00035
(dsrm)
PF14622
(Ribonucleas_3_3) 		4 GLY A 110
SER A  34
ILE A 124
HIS A  32
 None
 1.23A 1yajJ-1o0wA:
undetectable		 1yajJ-1o0wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Arabidopsis
thaliana) 		PF00903
(Glyoxalase) 		4 GLY A 184
SER A  55
ILE A  99
HIS A  64
 None
 1.13A 1yajJ-1tg5A:
undetectable		 1yajJ-1tg5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufo HYPOTHETICAL PROTEIN
TT1662

(Thermus
thermophilus) 		no annotation 4 GLY A  32
SER A 113
ILE A 185
HIS A 217
 None
 1.30A 1yajJ-1ufoA:
13.9		 1yajJ-1ufoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxo YDEN PROTEIN

(Bacillus
subtilis) 		PF06821
(Ser_hydrolase) 		4 GLY A  10
SER A  71
ILE A 139
HIS A 164
 None
 1.26A 1yajJ-1uxoA:
8.9		 1yajJ-1uxoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625

(Archaeoglobus
fulgidus) 		PF04414
(tRNA_deacylase) 		4 GLY A  81
SER A  78
ILE A  84
HIS A  76
 None
None
None
POP  A3000 (-3.8A)
 1.14A 1yajJ-1yqeA:
2.1		 1yajJ-1yqeA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmb ACETYLXYLAN ESTERASE
RELATED ENZYME

(Clostridium
acetobutylicum) 		PF03629
(SASA) 		4 GLY A  82
SER A  11
ILE A 206
HIS A 207
 None
 0.98A 1yajJ-1zmbA:
3.8		 1yajJ-1zmbA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoi ESTERASE

(Pseudomonas
putida) 		PF00561
(Abhydrolase_1) 		4 GLY A  30
SER A  97
ILE A 229
HIS A 256
 None
 1.19A 1yajJ-1zoiA:
12.5		 1yajJ-1zoiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A 217
SER A 370
ILE A 222
HIS A 419
 None
 1.00A 1yajJ-1zy8A:
undetectable		 1yajJ-1zy8A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a11 RIBONUCLEASE III

(Mycobacterium
tuberculosis) 		PF14622
(Ribonucleas_3_3) 		4 GLY A 103
SER A  29
ILE A 117
HIS A  27
 None
 1.14A 1yajJ-2a11A:
undetectable		 1yajJ-2a11A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be1 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 323
SER A 320
ILE A 326
HIS A 375
 None
 1.38A 1yajJ-2be1A:
undetectable		 1yajJ-2be1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		4 GLY A 483
SER A 476
ILE A  45
HIS A 486
 None
 1.14A 1yajJ-2cn3A:
undetectable		 1yajJ-2cn3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czq CUTINASE-LIKE
PROTEIN

(Cryptococcus
sp. S-2) 		PF01083
(Cutinase) 		4 GLY A  16
SER A  85
ILE A 176
HIS A 180
 EDO  A 602 (-3.4A)
EDO  A 602 ( 3.9A)
EDO  A 602 ( 4.9A)
EDO  A 602 ( 4.8A)
 0.82A 1yajJ-2czqA:
3.3		 1yajJ-2czqA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fx5 LIPASE

(Pseudomonas
mendocina) 		no annotation 4 GLY A  57
SER A 126
ILE A 178
HIS A 206
 None
 1.17A 1yajJ-2fx5A:
12.9		 1yajJ-2fx5A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5e HYPOTHETICAL PROTEIN
MM_2497

(Methanosarcina
mazei) 		PF01983
(CofC) 		4 GLY A 122
SER A 142
ILE A 115
HIS A 146
 TRS  A 302 (-3.6A)
None
None
None
 1.19A 1yajJ-2i5eA:
undetectable		 1yajJ-2i5eA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isb FUMARASE

(Archaeoglobus
fulgidus) 		PF05683
(Fumerase_C) 		4 GLY A 107
SER A  84
ILE A 103
HIS A  63
 None
 1.31A 1yajJ-2isbA:
undetectable		 1yajJ-2isbA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isb FUMARASE

(Archaeoglobus
fulgidus) 		PF05683
(Fumerase_C) 		4 GLY A 108
SER A  84
ILE A 103
HIS A  63
 None
 1.25A 1yajJ-2isbA:
undetectable		 1yajJ-2isbA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 GLY A 196
SER A  29
ILE A 211
HIS A 107
 None
 1.24A 1yajJ-2it4A:
undetectable		 1yajJ-2it4A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A  60
SER A  64
ILE A 430
HIS A  93
 None
 1.25A 1yajJ-2ji9A:
undetectable		 1yajJ-2ji9A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE

(Ruegeria sp.
TM1040) 		PF07859
(Abhydrolase_3) 		4 GLY A 211
SER A 166
ILE A 245
HIS A 135
 None
None
None
UNL  A 263 (-4.2A)
 1.33A 1yajJ-2pblA:
9.2		 1yajJ-2pblA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvp D-ALANINE-D-ALANINE
LIGASE

(Helicobacter
pylori) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 GLY A   8
SER A  17
ILE A 304
HIS A  96
 None
 1.04A 1yajJ-2pvpA:
undetectable		 1yajJ-2pvpA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxt LIPASE

(Bacillus
subtilis) 		PF01674
(Lipase_2) 		4 GLY A  11
SER A  77
ILE A 135
HIS A 156
 None
 1.32A 1yajJ-2qxtA:
9.9		 1yajJ-2qxtA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans) 		PF03069
(FmdA_AmdA) 		4 GLY A 245
SER A 247
ILE A  28
HIS A  21
 None
 1.28A 1yajJ-2wknA:
undetectable		 1yajJ-2wknA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		4 GLY A  84
SER A 157
ILE A 208
HIS A 284
 None
 1.30A 1yajJ-2yh2A:
8.3		 1yajJ-2yh2A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 GLY A   8
SER A  17
ILE A 286
HIS A  82
 None
None
None
DAL  A 401 (-4.5A)
 1.03A 1yajJ-2yzmA:
2.1		 1yajJ-2yzmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		4 GLY A 107
SER A  78
ILE A 378
HIS A 379
 SO4  A   3 (-3.5A)
SO4  A   3 ( 2.7A)
None
SO4  A   3 (-4.2A)
 1.30A 1yajJ-3bmaA:
undetectable		 1yajJ-3bmaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		4 GLY A 108
SER A  78
ILE A 378
HIS A 379
 SO4  A   3 (-3.9A)
SO4  A   3 ( 2.7A)
None
SO4  A   3 (-4.2A)
 1.41A 1yajJ-3bmaA:
undetectable		 1yajJ-3bmaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		4 GLY A 358
SER A 360
ILE A 436
HIS A 244
 None
 1.23A 1yajJ-3clqA:
undetectable		 1yajJ-3clqA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpi RAB GDP-DISSOCIATION
INHIBITOR

(Saccharomyces
cerevisiae) 		PF00996
(GDI) 		4 GLY G  75
SER G 356
ILE G 314
HIS G 359
 None
 1.40A 1yajJ-3cpiG:
undetectable		 1yajJ-3cpiG:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icv LIPASE B

(Moesziomyces
antarcticus) 		no annotation 4 GLY A  73
SER A 139
ILE A 223
HIS A 258
 None
None
BTB  A 403 ( 4.7A)
BTB  A 403 ( 4.9A)
 1.12A 1yajJ-3icvA:
11.6		 1yajJ-3icvA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP1
VP3

(Parechovirus B;
Parechovirus B) 		no annotation
PF00073
(Rhv) 		4 GLY A  89
SER A 223
ILE C  31
HIS A 133
 None
 1.11A 1yajJ-3jb4A:
undetectable		 1yajJ-3jb4A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k17 LIN0012 PROTEIN

(Listeria
innocua) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 GLY A 120
SER A 122
ILE A 166
HIS A 154
 None
 1.14A 1yajJ-3k17A:
undetectable		 1yajJ-3k17A:
22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		4 GLY A1142
SER A1221
ILE A1359
HIS A1468
 WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
WW2  A 193 ( 4.3A)
None
 0.34A 1yajJ-3k9bA:
60.9		 1yajJ-3k9bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		4 GLY A1143
SER A1221
ILE A1359
HIS A1468
 WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
WW2  A 193 ( 4.3A)
None
 0.76A 1yajJ-3k9bA:
60.9		 1yajJ-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksr PUTATIVE SERINE
HYDROLASE

(Xanthomonas
campestris) 		PF00326
(Peptidase_S9) 		4 GLY A  35
SER A 108
ILE A 188
HIS A 217
 None
PO4  A 290 ( 4.3A)
PO4  A 290 (-4.9A)
None
 1.30A 1yajJ-3ksrA:
3.9		 1yajJ-3ksrA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY
POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 293
SER A 267
ILE A  54
HIS A  55
 DAL  A2472 ( 4.5A)
None
None
None
 1.01A 1yajJ-3q4dA:
undetectable		 1yajJ-3q4dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		4 GLY A 287
SER A 290
ILE A  39
HIS A  36
 None
IPA  A 605 ( 4.1A)
IPA  A 605 ( 4.6A)
IPA  A 605 (-4.3A)
 1.06A 1yajJ-3q88A:
undetectable		 1yajJ-3q88A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9j MEMBER OF DUF4221
FAMILY

(Bacteroides
vulgatus) 		PF13970
(DUF4221) 		4 GLY A 108
SER A  55
ILE A  79
HIS A  68
 None
 1.30A 1yajJ-3s9jA:
undetectable		 1yajJ-3s9jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqt D-ALANINE--D-ALANINE
LIGASE

(Coxiella
burnetii) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 GLY A  12
SER A  21
ILE A 320
HIS A 107
 None
 1.13A 1yajJ-3tqtA:
undetectable		 1yajJ-3tqtA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyx ATP-DEPENDENT RNA
HELICASE A

(Homo sapiens) 		PF00035
(dsrm) 		4 GLY A 204
SER A 210
ILE A 212
HIS A 231
 None
 1.28A 1yajJ-3vyxA:
undetectable		 1yajJ-3vyxA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		4 GLY A 124
SER A 203
ILE A 419
HIS A 457
 None
 1.06A 1yajJ-3wmtA:
undetectable		 1yajJ-3wmtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		4 GLY A 125
SER A 203
ILE A 419
HIS A 457
 None
 1.00A 1yajJ-3wmtA:
undetectable		 1yajJ-3wmtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL HELICASE
SKI2
ANTIVIRAL PROTEIN
SKI8

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF00400
(WD40) 		4 GLY C  91
SER C  88
ILE A  20
HIS C  61
 None
 1.27A 1yajJ-4bujC:
undetectable		 1yajJ-4bujC:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccy CARBOXYLESTERASE
YBFK

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		4 GLY B  63
SER B 130
ILE B 186
HIS B 274
 None
 0.84A 1yajJ-4ccyB:
5.7		 1yajJ-4ccyB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccy CARBOXYLESTERASE
YBFK

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		4 GLY B  64
SER B 130
ILE B 186
HIS B 274
 None
 1.09A 1yajJ-4ccyB:
5.7		 1yajJ-4ccyB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg1 CUTINASE

(Thermobifida
fusca) 		PF12740
(Chlorophyllase2) 		4 GLY A  59
SER A 130
ILE A 178
HIS A 208
 None
 1.22A 1yajJ-4cg1A:
8.3		 1yajJ-4cg1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY

(Bacillus
subtilis) 		PF00171
(Aldedh) 		4 GLY A 186
SER A 151
ILE A 164
HIS A 176
 None
 1.34A 1yajJ-4dngA:
undetectable		 1yajJ-4dngA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		no annotation 4 GLY A 125
SER A 150
ILE A 133
HIS A 152
 None
 1.27A 1yajJ-4ezgA:
undetectable		 1yajJ-4ezgA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fu0 D-ALANINE--D-ALANINE
LIGASE 7

(Enterococcus
faecalis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 GLY A  11
SER A  20
ILE A 316
HIS A 106
 None
 1.16A 1yajJ-4fu0A:
undetectable		 1yajJ-4fu0A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)

(Geobacillus
kaustophilus) 		PF00854
(PTR2) 		4 GLY A 195
SER A  38
ILE A 105
HIS A 109
 None
 1.24A 1yajJ-4ikvA:
undetectable		 1yajJ-4ikvA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jiv PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF05488
(PAAR_motif) 		4 GLY D   2
SER D  89
ILE D   5
HIS D   9
 None
 1.13A 1yajJ-4jivD:
undetectable		 1yajJ-4jivD:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kav YHBX/YHJW/YIJP/YJDB
FAMILY PROTEIN

(Neisseria
meningitidis) 		PF00884
(Sulfatase) 		4 GLY A 277
SER A 283
ILE A 479
HIS A 511
 None
TPO  A 280 ( 4.5A)
None
None
 1.08A 1yajJ-4kavA:
undetectable		 1yajJ-4kavA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A3371
SER A3366
ILE A3478
HIS A3364
 None
 1.35A 1yajJ-4kc5A:
undetectable		 1yajJ-4kc5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3a INTERNALIN K

(Listeria
monocytogenes) 		no annotation 4 GLY A 132
SER A 157
ILE A 140
HIS A 159
 None
 1.34A 1yajJ-4l3aA:
undetectable		 1yajJ-4l3aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3f INTERNALIN K

(Listeria
monocytogenes) 		no annotation 4 GLY A 132
SER A 157
ILE A 140
HIS A 159
 None
 1.36A 1yajJ-4l3fA:
undetectable		 1yajJ-4l3fA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4q S-ADENOSYLMETHIONINE
SYNTHASE

(Thermococcus
kodakarensis) 		PF01941
(AdoMet_Synthase) 		4 GLY A 245
SER A 249
ILE A 178
HIS A 250
 None
 1.31A 1yajJ-4l4qA:
undetectable		 1yajJ-4l4qA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 GLY A 215
SER A 217
ILE A 211
HIS A 190
 None
 1.40A 1yajJ-4mvfA:
undetectable		 1yajJ-4mvfA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN

([Ruminococcus]
gnavus) 		no annotation 4 GLY E 275
SER E 301
ILE E 243
HIS E 272
 None
 0.89A 1yajJ-4obuE:
undetectable		 1yajJ-4obuE:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ose PUTATIVE HYDROLASE

(Rickettsia
typhi) 		PF00561
(Abhydrolase_1) 		4 GLY A  44
SER A 112
ILE A 149
HIS A 269
 None
 0.95A 1yajJ-4oseA:
6.3		 1yajJ-4oseA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oyy CUTINASE

(Humicola
insolens) 		PF01083
(Cutinase) 		4 GLY A  27
SER A 105
ILE A 169
HIS A 173
 None
 0.88A 1yajJ-4oyyA:
5.4		 1yajJ-4oyyA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psd CARBOHYDRATE
ESTERASE FAMILY 5

(Trichoderma
reesei) 		PF01083
(Cutinase) 		4 GLY A  89
SER A 164
ILE A 225
HIS A 229
 None
 0.79A 1yajJ-4psdA:
4.8		 1yajJ-4psdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3l MGS-M2

(unidentified) 		PF00561
(Abhydrolase_1) 		4 GLY A  31
SER A  97
ILE A 157
HIS A 249
 None
 0.92A 1yajJ-4q3lA:
5.7		 1yajJ-4q3lA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		4 GLY A 142
SER A 146
ILE A 253
HIS A 147
 None
 1.18A 1yajJ-4trrA:
3.6		 1yajJ-4trrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfi CUTINASE

(Saccharomonospora
viridis) 		PF03403
(PAF-AH_p_II) 		4 GLY A 105
SER A 176
ILE A 224
HIS A 254
 None
 1.22A 1yajJ-4wfiA:
8.4		 1yajJ-4wfiA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN

(Toxoplasma
gondii) 		PF02430
(AMA-1)
PF07974
(EGF_2) 		4 GLY A 107
SER A 442
ILE A  73
HIS A 456
 None
 1.36A 1yajJ-4z81A:
undetectable		 1yajJ-4z81A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8z UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 4 GLY A 101
SER A 187
ILE A 274
HIS A 302
 None
 1.09A 1yajJ-4z8zA:
6.0		 1yajJ-4z8zA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv7 LIPASE B

(Moesziomyces
antarcticus) 		no annotation 4 GLY A  39
SER A 105
ILE A 189
HIS A 224
 None
 1.15A 1yajJ-4zv7A:
5.8		 1yajJ-4zv7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLY A 149
SER A  98
ILE A 151
HIS A 152
 None
None
SF4  A 503 ( 4.7A)
SF4  A 503 ( 4.7A)
 1.37A 1yajJ-5aa5A:
undetectable		 1yajJ-5aa5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce5 TRIACYLGLYCEROL
LIPASE

(Geobacillus
thermocatenulatus) 		no annotation 4 GLY A  16
SER A 114
ILE A 320
HIS A 359
 P15  A 403 ( 4.2A)
P15  A 403 (-2.3A)
1PE  A 404 (-4.6A)
P15  A 403 (-4.2A)
 1.17A 1yajJ-5ce5A:
7.9		 1yajJ-5ce5A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crc SDEA

(Legionella
pneumophila) 		PF12252
(SidE) 		4 GLY A  83
SER A  86
ILE A  66
HIS A  64
 GLY  A  83 ( 0.0A)
SER  A  86 ( 0.0A)
ILE  A  66 ( 0.7A)
HIS  A  64 ( 1.0A)
 1.25A 1yajJ-5crcA:
undetectable		 1yajJ-5crcA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dni PUTATIVE
L(+)-TARTRATE
DEHYDRATASE SUBUNIT
BETA

(Methanocaldococcus
jannaschii) 		PF05683
(Fumerase_C) 		4 GLY A 105
SER A  82
ILE A 101
HIS A  60
 GOL  A 202 (-4.8A)
None
None
None
 1.31A 1yajJ-5dniA:
undetectable		 1yajJ-5dniA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dni PUTATIVE
L(+)-TARTRATE
DEHYDRATASE SUBUNIT
BETA

(Methanocaldococcus
jannaschii) 		PF05683
(Fumerase_C) 		4 GLY A 106
SER A  82
ILE A 101
HIS A  60
 GOL  A 202 (-3.5A)
None
None
None
 1.23A 1yajJ-5dniA:
undetectable		 1yajJ-5dniA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A

(Neisseria
meningitidis) 		PF00884
(Sulfatase)
PF08019
(DUF1705) 		4 GLY A 277
SER A 283
ILE A 479
HIS A 511
 None
 1.09A 1yajJ-5fgnA:
undetectable		 1yajJ-5fgnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 4 GLY A 486
SER A 479
ILE A  46
HIS A 489
 None
 1.13A 1yajJ-5fkrA:
undetectable		 1yajJ-5fkrA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3b UNCHARACTERIZED
PROTEIN HI_1552

(Haemophilus
influenzae) 		PF04301
(DUF452) 		4 GLY A  19
SER A  65
ILE A 123
HIS A 200
 IPA  A 302 (-3.6A)
IPA  A 302 (-2.6A)
IPA  A 302 ( 4.8A)
IPA  A 302 ( 4.6A)
 0.97A 1yajJ-5h3bA:
4.6		 1yajJ-5h3bA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3b UNCHARACTERIZED
PROTEIN HI_1552

(Haemophilus
influenzae) 		PF04301
(DUF452) 		4 GLY A  19
SER A  65
ILE A 177
HIS A 200
 IPA  A 302 (-3.6A)
IPA  A 302 (-2.6A)
IPA  A 302 ( 4.7A)
IPA  A 302 ( 4.6A)
 1.26A 1yajJ-5h3bA:
4.6		 1yajJ-5h3bA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		4 GLY A 454
SER A 447
ILE A  17
HIS A 457
 None
 1.15A 1yajJ-5jwzA:
undetectable		 1yajJ-5jwzA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 4 GLY A 701
SER A 695
ILE A 750
HIS A 697
 None
 1.24A 1yajJ-5ng6A:
undetectable		 1yajJ-5ng6A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no5 ABYA5

(Verrucosispora) 		no annotation 4 GLY A 150
SER A 217
ILE A 306
HIS A 331
 None
 1.02A 1yajJ-5no5A:
10.6		 1yajJ-5no5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u84 ACID CERAMIDASE

(Balaenoptera
acutorostrata) 		no annotation 4 GLY A 285
SER A 220
ILE A 147
HIS A 157
 None
 1.30A 1yajJ-5u84A:
undetectable		 1yajJ-5u84A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vto BLASTICIDIN M

(Streptomyces
griseochromogenes) 		no annotation 4 GLY A 101
SER A  99
ILE A 106
HIS A 103
 None
 1.24A 1yajJ-5vtoA:
undetectable		 1yajJ-5vtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 4 GLY A  86
SER A 160
ILE A 208
HIS A 237
 None
 1.23A 1yajJ-5xjhA:
13.8		 1yajJ-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		4 GLY A1076
SER A1078
ILE A1087
HIS A1068
 None
 1.17A 1yajJ-5xvmA:
2.3		 1yajJ-5xvmA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ane POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 4 GLY A  59
SER A 133
ILE A 181
HIS A 210
 None
 1.19A 1yajJ-6aneA:
8.4		 1yajJ-6aneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnf PHOSPHOETHANOLAMINE
TRANSFERASE

(Moraxella sp.
HMSC061H09) 		no annotation 4 GLY A 312
SER A 318
ILE A 525
HIS A 549
 GOL  A 610 ( 3.8A)
None
None
None
 1.06A 1yajJ-6bnfA:
undetectable		 1yajJ-6bnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE

(Staphylococcus
hominis) 		no annotation 4 GLY A 196
SER A  39
ILE A 106
HIS A 110
 None
 1.15A 1yajJ-6exsA:
undetectable		 1yajJ-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gww PEROXIREDOXIN

(Sulfolobus
islandicus) 		no annotation 4 GLY A  43
SER A  74
ILE A 100
HIS A  81
 None
 1.29A 1yajJ-6gwwA:
undetectable		 1yajJ-6gwwA:
undetectable