SIMILAR PATTERNS OF AMINO ACIDS FOR 1YAJ_G_BEZG3385_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae) 		PF00224
(PK)
PF02887
(PK_C) 		3 SER A 481
VAL A 423
LEU A 401
 None
 0.74A 1yajG-1a3xA:
1.5		 1yajG-1a3xA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)

(Trypanosoma
cruzi) 		PF00155
(Aminotran_1_2) 		3 SER A 348
VAL A 376
LEU A 390
 None
 0.74A 1yajG-1bw0A:
2.6		 1yajG-1bw0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg8 ENDOPOLYGALACTURONAS
E

(Fusarium
verticillioides) 		PF00295
(Glyco_hydro_28) 		3 SER A 257
VAL A 215
LEU A 236
 None
 0.65A 1yajG-1hg8A:
0.0		 1yajG-1hg8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		3 SER A 225
VAL A 183
LEU A 204
 None
 0.71A 1yajG-1ia5A:
0.6		 1yajG-1ia5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		3 SER A 252
VAL A 326
LEU A 264
 None
 0.71A 1yajG-1itxA:
0.0		 1yajG-1itxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kht ADENYLATE KINASE

(Methanococcus
voltae) 		PF13207
(AAA_17) 		3 SER A  20
VAL A 190
LEU A 191
 None
 0.49A 1yajG-1khtA:
undetectable		 1yajG-1khtA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		3 SER A 143
VAL A  56
LEU A 227
 None
 0.67A 1yajG-1m1cA:
0.0		 1yajG-1m1cA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 SER A 478
VAL A 462
LEU A 717
 None
 0.73A 1yajG-1naaA:
1.0		 1yajG-1naaA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1z GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Thermotoga
maritima) 		PF03009
(GDPD) 		3 SER A 111
VAL A  44
LEU A  81
 None
 0.64A 1yajG-1o1zA:
1.4		 1yajG-1o1zA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3g X-LINKED
INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1

(Homo sapiens) 		PF01582
(TIR) 		3 SER A 410
VAL A 507
LEU A 473
 None
 0.70A 1yajG-1t3gA:
undetectable		 1yajG-1t3gA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		3 SER A 367
VAL A  41
LEU A  36
 None
 0.74A 1yajG-1ur4A:
1.7		 1yajG-1ur4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyw FAB ANTIBODY LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER L 177
VAL L 115
LEU L 136
 None
 0.71A 1yajG-1uywL:
undetectable		 1yajG-1uywL:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5z MAJOR NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Aliivibrio
fischeri) 		PF00881
(Nitroreductase) 		3 SER A 121
VAL A 100
LEU A 101
 None
 0.72A 1yajG-1v5zA:
undetectable		 1yajG-1v5zA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc6 COAT PROTEIN

(Brome mosaic
virus) 		no annotation 3 SER A 128
VAL A 167
LEU A  96
 None
 0.64A 1yajG-1yc6A:
undetectable		 1yajG-1yc6A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yle ARGININE
N-SUCCINYLTRANSFERAS
E, ALPHA CHAIN

(Pseudomonas
aeruginosa) 		PF04958
(AstA) 		3 SER A 142
VAL A 162
LEU A 123
 FMT  A 601 ( 4.1A)
None
FMT  A 601 (-4.4A)
 0.72A 1yajG-1yleA:
undetectable		 1yajG-1yleA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b30 PVIVAX HYPOTHETICAL
PROTEIN

(Plasmodium
vivax) 		PF08282
(Hydrolase_3) 		3 SER A  65
VAL A 243
LEU A  29
 None
 0.65A 1yajG-2b30A:
undetectable		 1yajG-2b30A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bco SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio
parahaemolyticus) 		PF04952
(AstE_AspA) 		3 SER A 196
VAL A 311
LEU A 325
 None
 0.69A 1yajG-2bcoA:
4.9		 1yajG-2bcoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d99 GENERAL
TRANSCRIPTION FACTOR
II-I REPEAT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02946
(GTF2I) 		3 SER A  73
VAL A  18
LEU A  19
 None
 0.57A 1yajG-2d99A:
undetectable		 1yajG-2d99A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 SER A 491
VAL A 434
LEU A 438
 None
 0.68A 1yajG-2fonA:
undetectable		 1yajG-2fonA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4l URIDYLATE KINASE

(Sulfolobus
solfataricus) 		PF00696
(AA_kinase) 		3 SER A  26
VAL A 136
LEU A   5
 None
 0.72A 1yajG-2j4lA:
undetectable		 1yajG-2j4lA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ome C-TERMINAL-BINDING
PROTEIN 2

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 SER A 240
VAL A 206
LEU A 183
 None
 0.74A 1yajG-2omeA:
undetectable		 1yajG-2omeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00202
(Aminotran_3) 		3 SER A 253
VAL A 102
LEU A 267
 None
 0.67A 1yajG-2pb0A:
undetectable		 1yajG-2pb0A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q50 GLYOXYLATE
REDUCTASE/HYDROXYPYR
UVATE REDUCTASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 SER A 306
VAL A  11
LEU A  56
 None
 0.71A 1yajG-2q50A:
undetectable		 1yajG-2q50A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		3 SER A 214
VAL A 230
LEU A 234
 None
 0.66A 1yajG-2q80A:
undetectable		 1yajG-2q80A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		3 SER A 181
VAL A 120
LEU A 123
 None
 0.53A 1yajG-2qcvA:
undetectable		 1yajG-2qcvA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD

(Lactobacillus
paracasei) 		PF04909
(Amidohydro_2) 		3 SER A 167
VAL A 259
LEU A 224
 KCX  A 166 ( 4.7A)
None
None
 0.74A 1yajG-2qpxA:
undetectable		 1yajG-2qpxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu8 PA1645

(Pseudomonas
aeruginosa) 		PF16985
(DUF5086) 		3 SER A  89
VAL A  60
LEU A  42
 None
 0.63A 1yajG-2xu8A:
undetectable		 1yajG-2xu8A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		3 SER D 586
VAL D 619
LEU D 578
 None
 0.65A 1yajG-2yibD:
undetectable		 1yajG-2yibD:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		3 SER A 374
VAL A 264
LEU A 266
 None
 0.70A 1yajG-2yxlA:
undetectable		 1yajG-2yxlA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zt9 CYTOCHROME B6-F
COMPLEX SUBUNIT 4
CYTOCHROME B6-F
COMPLEX SUBUNIT 8

(Nostoc sp. PCC
7120;
Nostoc sp. PCC
7120) 		PF00032
(Cytochrom_B_C)
PF03742
(PetN) 		3 SER H  10
VAL B  56
LEU B  57
 None
 0.56A 1yajG-2zt9H:
undetectable		 1yajG-2zt9H:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		3 SER A 190
VAL A 202
LEU A  34
 None
 0.75A 1yajG-2ztsA:
undetectable		 1yajG-2ztsA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adr PUTATIVE
UNCHARACTERIZED
PROTEIN ST1585

(Sulfurisphaera
tokodaii) 		PF00753
(Lactamase_B) 		3 SER A 154
VAL A 203
LEU A 161
 None
 0.70A 1yajG-3adrA:
undetectable		 1yajG-3adrA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		3 SER A1421
VAL A1453
LEU A1449
 None
 0.72A 1yajG-3av6A:
undetectable		 1yajG-3av6A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgf F26G19 FAB

(Mus musculus) 		no annotation 3 SER L 177
VAL L 115
LEU L 136
 None
 0.72A 1yajG-3bgfL:
undetectable		 1yajG-3bgfL:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blx ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		3 SER B 324
VAL B 303
LEU B 300
 None
 0.72A 1yajG-3blxB:
undetectable		 1yajG-3blxB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3n DIHYDROOROTATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF01180
(DHO_dh) 		3 SER A  44
VAL A 124
LEU A  96
 SER  A  44 ( 0.0A)
VAL  A 124 ( 0.6A)
LEU  A  96 ( 0.6A)
 0.62A 1yajG-3c3nA:
2.3		 1yajG-3c3nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		3 SER A 682
VAL A 341
LEU A 388
 None
 0.55A 1yajG-3cskA:
undetectable		 1yajG-3cskA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 SER A 303
VAL A 333
LEU A 334
 None
 0.74A 1yajG-3d1jA:
undetectable		 1yajG-3d1jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxd AMYLOID BETA A4
PROTEIN-BINDING
FAMILY B MEMBER 1

(Homo sapiens) 		PF00640
(PID) 		3 SER A 584
VAL A 600
LEU A 593
 None
 0.71A 1yajG-3dxdA:
undetectable		 1yajG-3dxdA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eul POSSIBLE
NITRATE/NITRITE
RESPONSE
TRANSCRIPTIONAL
REGULATORY PROTEIN
NARL (DNA-BINDING
RESPONSE REGULATOR,
LUXR FAMILY)

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg) 		3 SER A  31
VAL A 122
LEU A 123
 None
 0.72A 1yajG-3eulA:
undetectable		 1yajG-3eulA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwi MAGNESIUM-TRANSPORTI
NG ATPASE, P-TYPE 1

(Escherichia
coli) 		PF13246
(Cation_ATPase) 		3 SER A 453
VAL A 477
LEU A 535
 None
 0.74A 1yajG-3gwiA:
undetectable		 1yajG-3gwiA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A 122
VAL A  86
LEU A   6
 None
 0.68A 1yajG-3i6eA:
undetectable		 1yajG-3i6eA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvg T-CELL SURFACE
GLYCOPROTEIN CD1A1
ANTIGEN

(Gallus gallus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		3 SER A  68
VAL A 154
LEU A 158
 UNL  A   1 (-3.9A)
None
UNL  A   1 (-3.6A)
 0.72A 1yajG-3jvgA:
undetectable		 1yajG-3jvgA:
17.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		3 SER A1221
VAL A1254
LEU A1255
 WW2  A 193 (-1.4A)
None
None
 0.32A 1yajG-3k9bA:
64.6		 1yajG-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Hahella
chejuensis) 		PF13407
(Peripla_BP_4) 		3 SER A 114
VAL A  44
LEU A 103
 None
 0.58A 1yajG-3ksmA:
undetectable		 1yajG-3ksmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		3 SER A  43
VAL A  33
LEU A  26
 None
 0.65A 1yajG-3lscA:
1.8		 1yajG-3lscA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzx FERREDOXIN--NADP
REDUCTASE 2

(Bacillus
subtilis) 		PF07992
(Pyr_redox_2) 		3 SER A 112
VAL A  93
LEU A 103
 None
 0.75A 1yajG-3lzxA:
undetectable		 1yajG-3lzxA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 SER A 389
VAL A 438
LEU A 254
 None
 0.54A 1yajG-3m1cA:
undetectable		 1yajG-3m1cA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00102
(Y_phosphatase) 		3 SER A   6
VAL A 287
LEU A 291
 None
 0.75A 1yajG-3m4uA:
undetectable		 1yajG-3m4uA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhu DIHYDROOROTATE
DEHYDROGENASE

(Leishmania
major) 		PF01180
(DHO_dh) 		3 SER A  43
VAL A 123
LEU A  95
 None
 0.73A 1yajG-3mhuA:
undetectable		 1yajG-3mhuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyi FAT ACID-BINDING
PROTEIN

(Eubacterium
ventriosum) 		PF02645
(DegV) 		3 SER A  96
VAL A 272
LEU A  27
 None
STE  A 301 ( 4.9A)
None
 0.74A 1yajG-3nyiA:
undetectable		 1yajG-3nyiA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		3 SER A 219
VAL A  95
LEU A 195
 None
 0.73A 1yajG-3o7wA:
undetectable		 1yajG-3o7wA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot4 PUTATIVE
ISOCHORISMATASE

(Bordetella
bronchiseptica) 		PF00857
(Isochorismatase) 		3 SER A  69
VAL A 142
LEU A  26
 None
 0.74A 1yajG-3ot4A:
undetectable		 1yajG-3ot4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmd CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF09385
(HisK_N) 		3 SER A  67
VAL A  49
LEU A  46
 None
None
11A  A 151 ( 4.4A)
 0.71A 1yajG-3pmdA:
undetectable		 1yajG-3pmdA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		3 SER A 323
VAL A 336
LEU A 340
 None
 0.74A 1yajG-3q9oA:
undetectable		 1yajG-3q9oA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 SER A 489
VAL A 470
LEU A 471
 None
 0.71A 1yajG-3redA:
undetectable		 1yajG-3redA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		3 SER A 261
VAL A 306
LEU A 194
 None
 0.74A 1yajG-3v8vA:
undetectable		 1yajG-3v8vA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wlw ANTIBODY L CHAIN

(Homo sapiens) 		no annotation 3 SER L 180
VAL L 118
LEU L 139
 None
 0.62A 1yajG-3wlwL:
undetectable		 1yajG-3wlwL:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		3 SER A 441
VAL A 105
LEU A 109
 None
 0.70A 1yajG-3zqjA:
undetectable		 1yajG-3zqjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3g DNA-BINDING PROTEIN
SMUBP-2

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		3 SER A 614
VAL A 636
LEU A 490
 None
 0.38A 1yajG-4b3gA:
undetectable		 1yajG-4b3gA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 SER A 428
VAL A 381
LEU A 378
 None
 0.73A 1yajG-4bejA:
undetectable		 1yajG-4bejA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 SER A 104
VAL A 217
LEU A 189
 None
 0.53A 1yajG-4eziA:
13.4		 1yajG-4eziA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr9 UNCHARACTERIZED
PROTEIN

(Bacteroides
fragilis) 		PF11396
(PepSY_like) 		3 SER A 106
VAL A 131
LEU A 141
 None
 0.73A 1yajG-4fr9A:
undetectable		 1yajG-4fr9A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		3 SER A 254
VAL A 298
LEU A 301
 None
 0.62A 1yajG-4gniA:
undetectable		 1yajG-4gniA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		3 SER B 146
VAL B  48
LEU B 115
 None
 0.72A 1yajG-4htfB:
undetectable		 1yajG-4htfB:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Rickettsia
bellii) 		PF02350
(Epimerase_2) 		3 SER A 101
VAL A  81
LEU A  82
 None
 0.66A 1yajG-4hwgA:
undetectable		 1yajG-4hwgA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 3 SER B 442
VAL B  65
LEU B  60
 None
 0.66A 1yajG-4iglB:
undetectable		 1yajG-4iglB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Pseudomonas
aeruginosa) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		3 SER A 142
VAL A  79
LEU A  87
 None
 0.34A 1yajG-4jb1A:
undetectable		 1yajG-4jb1A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj6 ACETYL XYLAN
ESTERASE

(Geobacillus
stearothermophilus) 		PF13472
(Lipase_GDSL_2) 		3 SER A  86
VAL A  56
LEU A   9
 None
 0.71A 1yajG-4jj6A:
2.3		 1yajG-4jj6A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2u ANTIBODY LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 SER L 177
VAL L 115
LEU L 136
 None
 0.73A 1yajG-4k2uL:
undetectable		 1yajG-4k2uL:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq9 RIBOSE ABC
TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Conexibacter
woesei) 		PF13407
(Peripla_BP_4) 		3 SER A  54
VAL A 132
LEU A 108
 None
 0.69A 1yajG-4kq9A:
undetectable		 1yajG-4kq9A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2

(Homo sapiens) 		no annotation 3 SER A 264
VAL A 196
LEU A 211
 ANP  A 401 (-3.0A)
None
ANP  A 401 (-4.9A)
 0.73A 1yajG-4nzmA:
undetectable		 1yajG-4nzmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkv LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		3 SER A 480
VAL A 549
LEU A 527
 None
 0.69A 1yajG-4pkvA:
undetectable		 1yajG-4pkvA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		3 SER A 276
VAL A 221
LEU A 231
 None
 0.74A 1yajG-4pvvA:
undetectable		 1yajG-4pvvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		3 SER A 492
VAL A 476
LEU A 732
 None
 0.75A 1yajG-4qi7A:
undetectable		 1yajG-4qi7A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Synechocystis
sp. PCC 6803) 		PF00698
(Acyl_transf_1) 		3 SER A 217
VAL A 100
LEU A  95
 None
 0.61A 1yajG-4rr5A:
undetectable		 1yajG-4rr5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wnz CRISPR SYSTEM CMR
SUBUNIT CMR4

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		3 SER A 238
VAL A 281
LEU A   8
 None
 0.74A 1yajG-4wnzA:
undetectable		 1yajG-4wnzA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv7 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		3 SER A  46
VAL A 124
LEU A 100
 None
 0.65A 1yajG-4yv7A:
2.7		 1yajG-4yv7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Trichophyton
rubrum) 		no annotation 3 SER D 108
VAL D 119
LEU D 148
 None
 0.68A 1yajG-4zhsD:
undetectable		 1yajG-4zhsD:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		3 SER A 156
VAL A 173
LEU A 133
 None
 0.73A 1yajG-5bxpA:
undetectable		 1yajG-5bxpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0n FAB CA33 LIGHT CHAIN

(Oryctolagus
cuniculus) 		no annotation 3 SER L 182
VAL L 120
LEU L 141
 None
 0.75A 1yajG-5c0nL:
undetectable		 1yajG-5c0nL:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 SER A 607
VAL A 588
LEU A 589
 None
 0.66A 1yajG-5i68A:
undetectable		 1yajG-5i68A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itg SORBITOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		3 SER A 400
VAL A 469
LEU A 470
 None
 0.63A 1yajG-5itgA:
undetectable		 1yajG-5itgA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY PROTEIN
LPTD

(Yersinia pestis) 		PF04453
(OstA_C) 		3 SER A 119
VAL A 108
LEU A  86
 None
 0.75A 1yajG-5ixmA:
undetectable		 1yajG-5ixmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je3 METHYL TRANSFERASE

(Burkholderia
glumae) 		PF13847
(Methyltransf_31) 		3 SER A 133
VAL A  68
LEU A  46
 None
 0.59A 1yajG-5je3A:
undetectable		 1yajG-5je3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		3 SER A  79
VAL A  18
LEU A  24
 None
 0.70A 1yajG-5jzbA:
12.3		 1yajG-5jzbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldy IG DOMAIN PROTEIN
GROUP 1 DOMAIN
PROTEIN

(Yersinia
pseudotuberculosis) 		PF09134
(Invasin_D3) 		3 SER A1647
VAL A1722
LEU A1727
 None
 0.43A 1yajG-5ldyA:
undetectable		 1yajG-5ldyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lwl TRANSCRIPTIONAL
REGULATORY PROTEIN

(Lactobacillus
paracasei) 		PF00072
(Response_reg) 		3 SER A  33
VAL A  51
LEU A   5
 None
 0.71A 1yajG-5lwlA:
undetectable		 1yajG-5lwlA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpa 26S PROTEASE
REGULATORY SUBUNIT
6A

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		3 SER M 123
VAL M 148
LEU M  78
 None
 0.72A 1yajG-5mpaM:
undetectable		 1yajG-5mpaM:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		3 SER A1567
VAL A1587
LEU A1407
 None
 0.72A 1yajG-5mznA:
undetectable		 1yajG-5mznA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n40 PUTATIVE INVASIN

(Yersinia
pseudotuberculosis) 		PF05689
(DUF823)
PF09134
(Invasin_D3) 		3 SER A2455
VAL A2530
LEU A2535
 None
 0.61A 1yajG-5n40A:
undetectable		 1yajG-5n40A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 SER A 353
VAL A 337
LEU A 605
 None
 0.67A 1yajG-5nccA:
undetectable		 1yajG-5nccA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE

(Aspergillus
oryzae) 		no annotation 3 SER B 211
VAL B 573
LEU B 568
 None
 0.29A 1yajG-5oarB:
undetectable		 1yajG-5oarB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc9 -

(-) 		no annotation 3 SER A 248
VAL A 598
LEU A 602
 79M  A 707 (-3.5A)
79M  A 707 ( 4.9A)
None
 0.68A 1yajG-5oc9A:
undetectable		 1yajG-5oc9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe5 ANTHRANILATE--COA
LIGASE

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		3 SER A 223
VAL A 250
LEU A 201
 None
 0.66A 1yajG-5oe5A:
undetectable		 1yajG-5oe5A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgf UNCHARACTERIZED
PROTEIN

(Bacteroides
dorei) 		PF00144
(Beta-lactamase) 		3 SER A 184
VAL A  56
LEU A 203
 None
 0.70A 1yajG-5tgfA:
undetectable		 1yajG-5tgfA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui3 DIHYDRODIPICOLINATE
SYNTHASE

(Chlamydomonas
reinhardtii) 		no annotation 3 SER D 222
VAL D  59
LEU D  28
 None
 0.74A 1yajG-5ui3D:
undetectable		 1yajG-5ui3D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 3 SER A 441
VAL A  87
LEU A  88
 NA  A1224 (-3.5A)
AQD  A1201 ( 4.6A)
None
 0.75A 1yajG-5wivA:
undetectable		 1yajG-5wivA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yal ESTERASE

(Streptomyces
cinnamoneus) 		no annotation 3 SER A 176
VAL A  43
LEU A  21
 None
 0.70A 1yajG-5yalA:
7.9		 1yajG-5yalA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9

(Danio rerio) 		no annotation 3 SER C 188
VAL C 508
LEU C 509
 None
 0.62A 1yajG-6c08C:
undetectable		 1yajG-6c08C:
undetectable