SIMILAR PATTERNS OF AMINO ACIDS FOR 1YA4_C_CTXC3_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aos ARGININOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 GLY A 200
VAL A 211
SER A  42
LEU A 216
LEU A  49
 None
 1.03A 1ya4C-1aosA:
undetectable		 1ya4C-1aosA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azw PROLINE
IMINOPEPTIDASE

(Xanthomonas
citri) 		PF00561
(Abhydrolase_1) 		5 PHE A 234
GLY A  43
GLY A  42
LEU A 138
LEU A 132
 None
 0.87A 1ya4C-1azwA:
12.5		 1ya4C-1azwA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		5 GLY A1046
GLY A1047
SER A 948
LEU A 960
HIS A1039
 None
 1.04A 1ya4C-1c30A:
2.8		 1ya4C-1c30A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chd CHEB METHYLESTERASE

(Salmonella
enterica) 		PF01339
(CheB_methylest) 		5 GLY A 277
VAL A 174
LEU A 280
LEU A 158
LEU A 175
 None
 0.92A 1ya4C-1chdA:
2.2		 1ya4C-1chdA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cij PROTEIN (HALOALKANE
DEHALOGENASE)

(Xanthobacter
autotrophicus) 		PF00561
(Abhydrolase_1) 		5 GLY A 127
GLY A 130
LEU A 120
LEU A 133
LEU A 109
 None
 0.98A 1ya4C-1cijA:
11.8		 1ya4C-1cijA:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		5 GLY A 122
GLY A 123
SER A 209
LEU A 297
HIS A 449
 CLL  A 801 (-4.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
CLL  A 801 (-4.8A)
 1.06A 1ya4C-1cleA:
39.8		 1ya4C-1cleA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
SER A 209
LEU A 304
HIS A 449
 None
 0.93A 1ya4C-1crlA:
39.4		 1ya4C-1crlA:
30.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 234
GLY A 233
SER A 195
LEU A 240
LEU A  61
 None
None
LLP  A 198 ( 2.8A)
None
None
 0.97A 1ya4C-1cs1A:
undetectable		 1ya4C-1cs1A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE

(Escherichia
coli) 		PF00378
(ECH_1) 		6 GLY A 109
GLY A 110
LEU A  28
SER A  29
LEU A  85
LEU A  71
 2CP  A 270 ( 3.8A)
2CP  A 270 (-3.4A)
None
None
None
None
 1.44A 1ya4C-1ef9A:
undetectable		 1ya4C-1ef9A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		5 GLY A  83
GLY A  84
SER A 155
LEU A 205
HIS A 282
 EPE  A 455 (-3.3A)
EPE  A 455 (-3.3A)
EPE  A 455 (-1.4A)
None
EPE  A 455 (-4.0A)
 0.44A 1ya4C-1evqA:
17.5		 1ya4C-1evqA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1goj KINESIN HEAVY CHAIN

(Neurospora
crassa) 		PF00225
(Kinesin) 		5 GLY A 297
GLY A 296
VAL A 268
SER A 278
LEU A 272
 None
 1.04A 1ya4C-1gojA:
undetectable		 1ya4C-1gojA:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		7 GLY A 122
GLY A 123
SER A 209
VAL A 296
LEU A 127
LEU A 297
HIS A 449
 None
 1.27A 1ya4C-1gz7A:
39.9		 1ya4C-1gz7A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 122
LEU A 127
LEU A 344
LEU A 304
HIS A 449
 None
 0.98A 1ya4C-1gz7A:
39.9		 1ya4C-1gz7A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
SER A 209
LEU A 344
HIS A 449
 None
 0.67A 1ya4C-1gz7A:
39.9		 1ya4C-1gz7A:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		5 GLY A 336
VAL A 267
LEU A 325
SER A 324
LEU A 263
 None
 1.06A 1ya4C-1iugA:
undetectable		 1ya4C-1iugA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT
GLYCEROL DEHYDRATASE
GAMMA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU)
PF02287
(Dehydratase_SU) 		5 GLY A 471
VAL G  37
LEU A 491
LEU A 427
LEU G  38
 None
 1.06A 1ya4C-1iwpA:
undetectable		 1ya4C-1iwpA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr9 MANGANESE SUPEROXIDE
DISMUTASE

(Virgibacillus
halodenitrificans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 GLY A  77
GLY A  76
LEU A  54
SER A  53
LEU A  49
 None
 0.96A 1ya4C-1jr9A:
undetectable		 1ya4C-1jr9A:
16.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		5 PHE A 101
GLY A 142
GLY A 143
SER A 221
HIS A 467
 None
 0.77A 1ya4C-1k4yA:
64.1		 1ya4C-1k4yA:
82.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		5 GLY A  88
GLY A  89
SER A 160
LEU A 208
HIS A 290
 CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
CAC  A 500 (-3.5A)
None
CAC  A 500 (-4.1A)
 0.94A 1ya4C-1lzkA:
18.7		 1ya4C-1lzkA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		5 GLY A 313
VAL A 181
LEU A 286
LEU A 333
MET A 321
 None
 1.04A 1ya4C-1mpxA:
16.5		 1ya4C-1mpxA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjs HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		5 GLY A 180
SER A 167
VAL A 201
SER A  28
LEU A 206
 None
CL  A 511 (-4.9A)
None
None
None
 1.06A 1ya4C-1qjsA:
undetectable		 1ya4C-1qjsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		5 GLY A 117
VAL A  77
SER A  50
LEU A 166
LEU A  57
 None
 1.02A 1ya4C-1txoA:
undetectable		 1ya4C-1txoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufo HYPOTHETICAL PROTEIN
TT1662

(Thermus
thermophilus) 		no annotation 6 GLY A 111
GLY A 112
LEU A 219
LEU A 176
MET A 223
HIS A 177
 None
 1.33A 1ya4C-1ufoA:
14.5		 1ya4C-1ufoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6f ARYLAMINE
N-ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF00797
(Acetyltransf_2) 		5 PHE A 179
VAL A  29
LEU A  77
LEU A 141
LEU A  25
 None
 1.03A 1ya4C-1w6fA:
undetectable		 1ya4C-1w6fA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00378
(ECH_1) 		5 GLY A 141
GLY A 140
LEU A  57
SER A  58
LEU A  97
 None
 0.98A 1ya4C-1xx4A:
2.1		 1ya4C-1xx4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhg TRNA SELENOCYSTEINE
ASSOCIATED PROTEIN
(SECP43)

(Homo sapiens) 		PF00076
(RRM_1) 		5 GLY A 125
GLY A 126
VAL A 100
LEU A 112
LEU A 170
 None
 1.06A 1ya4C-2dhgA:
undetectable		 1ya4C-2dhgA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehp AQ_1627 PROTEIN

(Aquifex
aeolicus) 		no annotation 6 GLY A  62
GLY A  29
LEU A  47
LEU A  32
LEU A  57
LEU A  90
 None
 1.49A 1ya4C-2ehpA:
undetectable		 1ya4C-2ehpA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehp AQ_1627 PROTEIN

(Aquifex
aeolicus) 		no annotation 6 GLY A  62
GLY A  29
LEU A  47
SER A  48
LEU A  32
LEU A  57
 None
 1.49A 1ya4C-2ehpA:
undetectable		 1ya4C-2ehpA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		5 PHE A 176
GLY A 157
LEU A  51
LEU A 168
LEU A 116
 None
 1.06A 1ya4C-2fuqA:
undetectable		 1ya4C-2fuqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htm PUTATIVE THIAMINE
BIOSYNTHESIS PROTEIN
THIS

(Thermus
thermophilus) 		PF02597
(ThiS) 		5 GLY E  41
VAL E  55
LEU E  16
MET E  23
LEU E   4
 None
 0.98A 1ya4C-2htmE:
undetectable		 1ya4C-2htmE:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqg TALIN-1

(Mus musculus) 		no annotation 5 GLY A 998
GLY A 997
LEU A1027
SER A 927
LEU A 966
 None
 1.03A 1ya4C-2lqgA:
undetectable		 1ya4C-2lqgA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		5 GLY A 552
GLY A 553
VAL A 518
LEU A 554
LEU A 242
 None
 1.06A 1ya4C-2nyfA:
undetectable		 1ya4C-2nyfA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		5 GLY A  92
GLY A  93
SER A 169
LEU A  22
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
 0.78A 1ya4C-2o7rA:
18.3		 1ya4C-2o7rA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 GLY A 370
GLY A 369
VAL A 390
LEU A 381
SER A 382
 None
 0.89A 1ya4C-2okkA:
2.1		 1ya4C-2okkA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		5 GLY A 157
VAL A 107
LEU A  26
SER A  27
LEU A  77
 None
 0.98A 1ya4C-2owzA:
undetectable		 1ya4C-2owzA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 169
GLY A 170
VAL A 213
LEU A 196
LEU A 217
 None
 0.97A 1ya4C-2pp3A:
undetectable		 1ya4C-2pp3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk2 LP04448P

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		5 GLY A 464
VAL A 482
LEU A 444
SER A 443
LEU A 448
 None
 1.03A 1ya4C-2qk2A:
undetectable		 1ya4C-2qk2A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkj TYROSYL-TRNA
SYNTHETASE

(Neurospora
crassa) 		PF00579
(tRNA-synt_1b) 		5 GLY A 112
VAL A 400
LEU A 117
LEU A 363
LEU A 399
 None
 1.03A 1ya4C-2rkjA:
undetectable		 1ya4C-2rkjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10

(Rattus
norvegicus) 		PF01344
(Kelch_1) 		5 GLY A 352
GLY A 351
VAL A 402
LEU A 364
LEU A 418
 None
 0.91A 1ya4C-2wozA:
undetectable		 1ya4C-2wozA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbm PROTEIN-TYROSINE-PHO
SPHATASE

(Shewanella sp.) 		PF00149
(Metallophos) 		5 GLY A 208
GLY A 209
VAL A 300
SER A 262
LEU A 295
 None
 1.03A 1ya4C-2zbmA:
undetectable		 1ya4C-2zbmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b74 UNCHARACTERIZED
PROTEIN YKL091C

(Saccharomyces
cerevisiae) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 GLY A 268
GLY A 267
LEU A 254
LEU A 123
LEU A 245
 None
 1.03A 1ya4C-3b74A:
undetectable		 1ya4C-3b74A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbl REGULATORY PROTEIN
OF LACI FAMILY

(Chloroflexus
aggregans) 		PF13377
(Peripla_BP_3) 		5 GLY A 122
SER A  63
VAL A 317
LEU A 101
LEU A 313
 None
 1.00A 1ya4C-3bblA:
2.8		 1ya4C-3bblA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjw COUP TRANSCRIPTION
FACTOR 2

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 VAL A 307
LEU A 367
LEU A 363
LEU A 252
LEU A 302
 None
 0.94A 1ya4C-3cjwA:
undetectable		 1ya4C-3cjwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7r ESTERASE

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		5 GLY A 152
GLY A 154
LEU A 157
LEU A  98
HIS A  95
 None
None
None
DMS  A1417 (-3.9A)
None
 1.01A 1ya4C-3d7rA:
15.2		 1ya4C-3d7rA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnh UNCHARACTERIZED
PROTEIN ATU2129

(Agrobacterium
fabrum) 		PF13883
(Pyrid_oxidase_2) 		5 GLY A 109
VAL A  89
LEU A 147
MET A  81
LEU A  42
 None
 1.06A 1ya4C-3dnhA:
undetectable		 1ya4C-3dnhA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e19 FEOA

(Thermococcus
thioreducens) 		PF04023
(FeoA) 		5 GLY A  39
VAL A  72
SER A  56
LEU A  77
LEU A   7
 None
 1.02A 1ya4C-3e19A:
undetectable		 1ya4C-3e19A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		5 GLY A 164
LEU A 125
LEU A 323
LEU A 133
LEU A 316
 None
 0.82A 1ya4C-3e3pA:
undetectable		 1ya4C-3e3pA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY H 193
SER H 195
LEU H  40
LEU H  64
HIS H  57
 0G6  H   1 (-4.1A)
0G6  H   1 (-1.8A)
None
None
0G6  H   1 (-3.2A)
 0.94A 1ya4C-3f6uH:
undetectable		 1ya4C-3f6uH:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd7 FUSION COMPLEX OF
CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR, RESIDUES
1193-1427 AND
MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK,
RESIDUES 219-371

(Escherichia
coli;
Homo sapiens) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 VAL A1475
LEU A1451
SER A1491
LEU A1467
LEU A1477
 None
 0.99A 1ya4C-3gd7A:
undetectable		 1ya4C-3gd7A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN

(Ralstonia
solanacearum) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 PHE A 203
GLY A 257
LEU A 236
MET A 211
LEU A 226
 None
 0.89A 1ya4C-3ghyA:
undetectable		 1ya4C-3ghyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A  89
GLY A  90
SER A 157
LEU A 192
HIS A 281
 None
 0.67A 1ya4C-3k6kA:
16.8		 1ya4C-3k6kA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A  89
GLY A  90
SER A 157
LEU A 206
HIS A 281
 None
 0.62A 1ya4C-3k6kA:
16.8		 1ya4C-3k6kA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		9 PHE A1101
GLY A1142
GLY A1143
SER A1221
VAL A1254
LEU A1358
MET A1364
LEU A1388
HIS A1468
 None
WW2  A 193 (-3.4A)
WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
None
None
None
None
None
 0.46A 1ya4C-3k9bA:
61.6		 1ya4C-3k9bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		6 PHE A1101
SER A1221
SER A1365
MET A1364
LEU A1388
HIS A1468
 None
WW2  A 193 (-1.4A)
None
None
None
None
 1.43A 1ya4C-3k9bA:
61.6		 1ya4C-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maj DNA PROCESSING CHAIN
A

(Rhodopseudomonas
palustris) 		PF02481
(DNA_processg_A) 		6 GLY A 185
GLY A 186
VAL A  87
LEU A 215
LEU A 230
LEU A  89
 None
 1.45A 1ya4C-3majA:
undetectable		 1ya4C-3majA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 GLY A  37
GLY A  77
VAL A  62
LEU A  78
LEU A  57
 None
 0.97A 1ya4C-3nvsA:
undetectable		 1ya4C-3nvsA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odn DALLY-LIKE PROTEIN

(Drosophila
melanogaster) 		PF01153
(Glypican) 		5 LEU A 259
SER A 260
LEU A 220
MET A 213
LEU A 198
 None
 1.06A 1ya4C-3odnA:
undetectable		 1ya4C-3odnA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq3 IFN-ALPHA/BETA
BINDING PROTEIN C12R

(Ectromelia
virus) 		PF00047
(ig)
PF13895
(Ig_2) 		5 GLY B  34
GLY B  33
VAL B 108
LEU B  58
SER B  59
 None
 1.03A 1ya4C-3oq3B:
undetectable		 1ya4C-3oq3B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		6 GLY A 126
GLY A 127
VAL A 434
LEU A  23
LEU A 448
HIS A  96
 None
None
None
None
None
ZN  A 501 (-3.3A)
 1.17A 1ya4C-3pfeA:
2.2		 1ya4C-3pfeA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3r FERRIPYOCHELIN
BINDING PROTEIN

(Salmonella
enterica) 		PF00132
(Hexapep) 		6 GLY A 125
SER A 128
VAL A  93
LEU A 105
LEU A 136
LEU A  95
 None
 1.32A 1ya4C-3r3rA:
undetectable		 1ya4C-3r3rA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK

(Escherichia
coli) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 VAL A 266
LEU A 242
SER A 282
LEU A 258
LEU A 268
 None
 1.04A 1ya4C-3rlfA:
2.8		 1ya4C-3rlfA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A 152
GLY A 153
VAL A 131
LEU A 200
LEU A  74
LEU A 147
 None
None
SL0  A 400 (-3.9A)
SL0  A 400 (-4.7A)
None
SL0  A 400 (-3.7A)
 1.49A 1ya4C-3ubdA:
undetectable		 1ya4C-3ubdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		5 GLY A 291
VAL A 136
LEU A 321
LEU A 134
MET A 317
 None
 0.95A 1ya4C-3vexA:
undetectable		 1ya4C-3vexA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vom PUTATIVE
PHOSPHOSERINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		5 GLY A 182
VAL A 186
LEU A  68
LEU A 274
LEU A 210
 None
 0.80A 1ya4C-3vomA:
undetectable		 1ya4C-3vomA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 5 PHE A 179
GLY A 198
GLY A 197
SER A 222
LEU A 139
 None
 0.93A 1ya4C-3wevA:
undetectable		 1ya4C-3wevA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		5 GLY A 124
GLY A 125
SER A 203
LEU A 126
HIS A 457
 None
 0.80A 1ya4C-3wmtA:
11.3		 1ya4C-3wmtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		6 PHE G 209
GLY G  85
GLY G  89
VAL G  57
LEU G  92
LEU G  11
 None
 1.50A 1ya4C-4adsG:
undetectable		 1ya4C-4adsG:
17.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 133
LEU A 138
LEU A 355
LEU A 315
HIS A 465
 None
None
PEG  A1555 (-4.6A)
1PE  A1553 (-4.3A)
None
 1.02A 1ya4C-4be9A:
41.1		 1ya4C-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 134
GLY A 135
SER A 220
LEU A 355
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
PEG  A1555 (-4.6A)
None
 0.66A 1ya4C-4be9A:
41.1		 1ya4C-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 135
SER A 220
SER A 311
LEU A 355
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
PEG  A1555 (-4.6A)
None
 0.93A 1ya4C-4be9A:
41.1		 1ya4C-4be9A:
32.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A

(Aspergillus
tubingensis) 		PF00295
(Glyco_hydro_28) 		5 GLY A 256
VAL A 299
SER A 320
LEU A 258
LEU A 338
 SO4  A1407 (-4.8A)
None
None
None
None
 1.06A 1ya4C-4c2lA:
undetectable		 1ya4C-4c2lA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqy ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 GLY A 163
SER A 166
VAL A 130
LEU A 174
LEU A 132
 None
 0.98A 1ya4C-4eqyA:
undetectable		 1ya4C-4eqyA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flm S-FORMYLGLUTATHIONE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF00756
(Esterase) 		5 GLY A 159
SER A 184
VAL A 281
SER A  66
HIS A 292
 None
 1.04A 1ya4C-4flmA:
14.8		 1ya4C-4flmA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		5 GLY A  66
SER A 308
LEU A 161
SER A 160
LEU A 177
 None
 0.93A 1ya4C-4jccA:
undetectable		 1ya4C-4jccA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jot ENOYL-COA HYDRATASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF00378
(ECH_1) 		5 GLY A 153
GLY A 154
LEU A 141
SER A 140
LEU A 187
 None
 0.83A 1ya4C-4jotA:
undetectable		 1ya4C-4jotA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jot ENOYL-COA HYDRATASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF00378
(ECH_1) 		5 GLY A 153
LEU A 141
SER A 140
LEU A 124
LEU A 187
 None
 1.02A 1ya4C-4jotA:
undetectable		 1ya4C-4jotA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqt PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF06439
(DUF1080) 		6 GLY A 313
VAL A 302
LEU A 430
LEU A 431
LEU A 358
LEU A 300
 NA  A 502 ( 4.2A)
None
None
None
None
None
 1.32A 1ya4C-4jqtA:
undetectable		 1ya4C-4jqtA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN

(Mus musculus) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		5 GLY A  46
VAL A 154
LEU A 103
SER A 102
LEU A 144
 PC1  A 506 (-3.4A)
None
PC1  A 506 (-4.8A)
None
None
 1.05A 1ya4C-4m4dA:
undetectable		 1ya4C-4m4dA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		6 PHE A 260
GLY A 278
VAL A 296
LEU A 283
LEU A 309
LEU A 297
 None
 1.33A 1ya4C-4mcaA:
undetectable		 1ya4C-4mcaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfv BETA-CATENIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF08216
(CTNNBL) 		5 PHE A 383
GLY A 378
LEU A 357
LEU A 336
LEU A 411
 None
 0.99A 1ya4C-4mfvA:
undetectable		 1ya4C-4mfvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhu ECTOINE HYDROXYLASE

(Sphingopyxis
alaskensis) 		PF05721
(PhyH) 		5 GLY A  45
VAL A 180
LEU A 243
LEU A  49
LEU A 178
 None
 0.93A 1ya4C-4mhuA:
undetectable		 1ya4C-4mhuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4p ACYLNEURAMINATE
LYASE

(Mycoplasma
synoviae) 		PF00701
(DHDPS) 		5 PHE A  18
GLY A  52
GLY A  49
MET A  66
LEU A  94
 None
None
CL  A 300 ( 4.1A)
None
None
 1.03A 1ya4C-4n4pA:
undetectable		 1ya4C-4n4pA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4r LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Salmonella
enterica) 		PF04390
(LptE) 		5 GLY B  41
VAL B  51
SER B 107
LEU B  38
LEU B 155
 None
 1.06A 1ya4C-4n4rB:
undetectable		 1ya4C-4n4rB:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc9 PUTATIVE
O-ACETYLHOMOSERINE
(THIOL)-LYASE

(Campylobacter
jejuni) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 215
VAL A 207
LEU A 273
SER A  61
LEU A 218
 None
 1.06A 1ya4C-4oc9A:
undetectable		 1ya4C-4oc9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 VAL A 658
LEU A 722
LEU A 718
LEU A 603
LEU A 653
 None
 0.87A 1ya4C-4p6wA:
undetectable		 1ya4C-4p6wA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhz CRY23AA1

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		5 VAL A 110
SER A 253
LEU A 225
LEU A 249
LEU A 260
 None
 1.03A 1ya4C-4rhzA:
undetectable		 1ya4C-4rhzA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrp ANTIGEN ASF1P

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		5 GLY M   8
VAL M 109
LEU M   6
LEU M  12
LEU M  97
 None
 1.06A 1ya4C-4rrpM:
undetectable		 1ya4C-4rrpM:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucw HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA

(Desulfovibrio
fructosivorans) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 LEU A  42
SER A  41
LEU A  35
LEU A  72
LEU A 162
 None
 1.06A 1ya4C-4ucwA:
undetectable		 1ya4C-4ucwA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ur8 KETO-DEOXY-D-GALACTA
RATE DEHYDRATASE

(Agrobacterium
tumefaciens) 		PF00701
(DHDPS) 		5 GLY A  55
GLY A  53
SER A 212
LEU A  48
LEU A 189
 None
OOG  A1305 (-3.1A)
None
None
None
 0.99A 1ya4C-4ur8A:
undetectable		 1ya4C-4ur8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfi CUTINASE

(Saccharomonospora
viridis) 		PF03403
(PAF-AH_p_II) 		5 PHE A 106
GLY A 178
GLY A 179
LEU A 183
HIS A 254
 None
 1.01A 1ya4C-4wfiA:
14.0		 1ya4C-4wfiA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML

(Bacillus
velezensis) 		PF13847
(Methyltransf_31) 		5 GLY A 221
GLY A 220
LEU A 232
MET A 233
LEU A 242
 None
 1.03A 1ya4C-5dlyA:
undetectable		 1ya4C-5dlyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 GLY A  15
GLY A  16
VAL A 124
LEU A 111
HIS A 112
 FAD  A 401 (-3.3A)
None
None
None
None
 0.92A 1ya4C-5eowA:
undetectable		 1ya4C-5eowA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		5 GLY B 172
GLY B 173
VAL B 217
SER B 137
LEU B 195
 None
 0.92A 1ya4C-5ergB:
undetectable		 1ya4C-5ergB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO

(Homo sapiens) 		PF12933
(FTO_NTD)
PF12934
(FTO_CTD) 		5 GLY A 498
VAL A 421
LEU A 439
LEU A 435
LEU A 418
 None
 0.99A 1ya4C-5f8pA:
undetectable		 1ya4C-5f8pA:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		7 PHE A  84
GLY A 125
GLY A 126
SER A 204
LEU A 340
MET A 345
HIS A 449
 None
 0.55A 1ya4C-5fv4A:
66.5		 1ya4C-5fv4A:
78.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A 108
GLY A 109
SER A 188
LEU A 239
HIS A 317
 TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
 0.50A 1ya4C-5hc4A:
20.3		 1ya4C-5hc4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i10 PROBABLE
O-METHYLTRANSFERASE

(Saccharopolyspora
spinosa) 		PF05711
(TylF) 		5 PHE A 162
GLY A  87
GLY A  88
LEU A  16
LEU A 156
 None
 1.06A 1ya4C-5i10A:
undetectable		 1ya4C-5i10A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in2 EXTRACELLULAR
SUPEROXIDE DISMUTASE
[CU-ZN]

(Onchocerca
volvulus) 		PF00080
(Sod_Cu) 		5 GLY A  90
GLY A  93
VAL A  14
LEU A  42
LEU A 147
 PGE  A 206 ( 3.2A)
None
None
PGE  A 206 (-3.6A)
None
 0.95A 1ya4C-5in2A:
undetectable		 1ya4C-5in2A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		5 PHE A 233
GLY A 172
GLY A 173
LEU A 146
LEU A 211
 None
 0.84A 1ya4C-5inrA:
undetectable		 1ya4C-5inrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j90 RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12741
(SusD-like) 		5 GLY A 369
GLY A 368
VAL A 248
LEU A 362
LEU A 226
 None
None
EDO  A 604 (-3.4A)
None
None
 1.06A 1ya4C-5j90A:
undetectable		 1ya4C-5j90A:
20.79