SIMILAR PATTERNS OF AMINO ACIDS FOR 1YA4_C_CTXC1383

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		4 TRP A 301
PRO A 268
LEU A 230
GLY A 232
 None
 1.46A 1ya4C-1a5cA:
1.4		 1ya4C-1a5cA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Drosophila
melanogaster) 		PF00274
(Glycolytic) 		4 TRP A 295
PRO A 261
LEU A 223
GLY A 225
 None
 1.30A 1ya4C-1fbaA:
0.7		 1ya4C-1fbaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 TRP A1295
PRO A1261
LEU A1223
GLY A1225
 None
 1.30A 1ya4C-1fdjA:
1.3		 1ya4C-1fdjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE

(Escherichia
coli) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 TRP A  34
PRO A 105
LEU A 126
GLY A 123
 None
 1.10A 1ya4C-1kqjA:
undetectable		 1ya4C-1kqjA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo0 TRIOSEPHOSPHATE
ISOMERASE

(Caenorhabditis
elegans) 		PF00121
(TIM) 		4 TRP A  89
LEU A  87
GLY A  86
LYS A  51
 None
 1.46A 1ya4C-1mo0A:
undetectable		 1ya4C-1mo0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrb NEUROTOXIN V, CSE-V

(Centruroides
sculpturatus) 		PF00537
(Toxin_3) 		4 PRO A  53
LEU A  48
GLY A  47
LYS A  30
 None
 1.13A 1ya4C-1nrbA:
undetectable		 1ya4C-1nrbA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pfx FACTOR IXA

(Sus scrofa) 		PF00089
(Trypsin) 		4 PRO C 161
LEU C 158
GLY C  19
LYS C 188
 None
 1.43A 1ya4C-1pfxC:
undetectable		 1ya4C-1pfxC:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 PRO A 169
LEU A  75
GLY A  74
LYS A 244
 None
NAP  A3075 ( 4.2A)
NAP  A3075 ( 4.7A)
None
 0.94A 1ya4C-1suwA:
2.4		 1ya4C-1suwA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 PRO A 169
LEU A  75
GLY A  74
LYS A 244
 None
NAP  A3076 (-4.3A)
NAP  A3076 ( 4.9A)
None
 0.90A 1ya4C-1z0uA:
2.5		 1ya4C-1z0uA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z INTERCELLULAR
ADHESION MOLECULE-1

(Homo sapiens) 		PF03921
(ICAM_N) 		4 PRO I  28
LEU I  31
GLY I  32
LYS I  50
 None
 1.33A 1ya4C-1z7zI:
undetectable		 1ya4C-1z7zI:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap1 PUTATIVE REGULATOR
PROTEIN

(Salmonella
enterica) 		PF00480
(ROK) 		4 TRP A 115
PRO A 144
LEU A 299
GLY A  61
 None
 1.28A 1ya4C-2ap1A:
undetectable		 1ya4C-2ap1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG

(Thermus
thermophilus) 		PF01887
(SAM_adeno_trans) 		4 PRO A  29
LEU A 147
GLY A 148
LYS A   1
 None
 1.36A 1ya4C-2cw5A:
undetectable		 1ya4C-2cw5A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2miz M04 IMMUNOEVASIN

(Murid
betaherpesvirus
1) 		PF12216
(m04gp34like) 		4 TRP A  58
PRO A  50
LEU A 172
GLY A  30
 None
 1.38A 1ya4C-2mizA:
undetectable		 1ya4C-2mizA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4x STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00567
(TUDOR) 		4 PRO B 748
LEU B 752
GLY B 753
LYS B 703
 None
 1.46A 1ya4C-2o4xB:
undetectable		 1ya4C-2o4xB:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbi PYRUVATE
DECARBOXYLASE

(Acetobacter
pasteurianus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TRP A 298
PRO A 299
LEU A 215
GLY A 217
 None
 1.40A 1ya4C-2vbiA:
undetectable		 1ya4C-2vbiA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B

(Mycobacterium
tuberculosis) 		PF02502
(LacAB_rpiB) 		4 PRO A  32
LEU A   8
GLY A   9
LYS A  18
 None
 0.94A 1ya4C-2vvqA:
undetectable		 1ya4C-2vvqA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 PRO A 726
LEU A 809
GLY A 814
LYS A 788
 None
 1.39A 1ya4C-2x2iA:
undetectable		 1ya4C-2x2iA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 TRP A 295
PRO A 261
LEU A 223
GLY A 225
 None
 1.30A 1ya4C-3bv4A:
undetectable		 1ya4C-3bv4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01759
(NTR)
PF07677
(A2M_recep) 		4 PRO C1452
LEU C1341
GLY C1339
LYS C1422
 None
 1.44A 1ya4C-3hs0C:
undetectable		 1ya4C-3hs0C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES21
40S RIBOSOMAL
PROTEIN US2

(Plasmodium
falciparum) 		PF00318
(Ribosomal_S2)
PF01249
(Ribosomal_S21e) 		4 PRO C 126
LEU C 153
GLY Z  62
LYS C  32
 None
 1.45A 1ya4C-3j7aC:
undetectable		 1ya4C-3j7aC:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		4 TRP A 293
PRO A 260
LEU A 222
GLY A 224
 None
 1.44A 1ya4C-3kx6A:
undetectable		 1ya4C-3kx6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		4 TRP A 319
LEU A 329
GLY A 328
LYS A  87
 None
 1.25A 1ya4C-3o7wA:
0.7		 1ya4C-3o7wA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 TRP A 286
PRO A 288
LEU A 284
GLY A 280
 None
 1.35A 1ya4C-3pdsA:
undetectable		 1ya4C-3pdsA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 4 TRP N  94
PRO N  93
LEU N 346
GLY N 342
 None
 1.44A 1ya4C-3rkoN:
0.9		 1ya4C-3rkoN:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq4 SN-GLYCEROL-3-PHOSPH
ATE-BINDING
PERIPLASMIC PROTEIN
UGPB

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 PRO A 143
LEU A 137
GLY A 136
LYS A 155
 None
 1.36A 1ya4C-4aq4A:
undetectable		 1ya4C-4aq4A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		4 TRP V1414
PRO V1411
LEU V1420
GLY V1346
 None
 1.42A 1ya4C-4bxsV:
undetectable		 1ya4C-4bxsV:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7m TIR
DOMAIN-CONTAINING
PROTEIN

(Brucella
melitensis) 		PF13676
(TIR_2) 		4 PRO A 224
LEU A 226
GLY A 202
LYS A 229
 None
 1.49A 1ya4C-4c7mA:
1.7		 1ya4C-4c7mA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TRP A 298
PRO A 299
LEU A 215
GLY A 217
 None
 1.45A 1ya4C-4cokA:
1.7		 1ya4C-4cokA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		4 PRO A 236
LEU A 206
GLY A 325
LYS A 244
 None
 1.46A 1ya4C-4eysA:
1.9		 1ya4C-4eysA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		4 TRP A 258
PRO A 260
LEU A 256
GLY A 252
 None
 1.39A 1ya4C-4gbrA:
undetectable		 1ya4C-4gbrA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn2 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		4 TRP A 157
PRO A  68
GLY A 210
LYS A 208
 KCX  A  66 ( 4.2A)
KCX  A  66 ( 4.5A)
None
KCX  A  66 ( 4.5A)
 1.49A 1ya4C-4gn2A:
1.6		 1ya4C-4gn2A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je1 PROBABLE THIOL
PEROXIDASE

(Burkholderia
cenocepacia) 		PF08534
(Redoxin) 		4 PRO A 126
LEU A   6
GLY A   8
LYS A 154
 None
 1.40A 1ya4C-4je1A:
undetectable		 1ya4C-4je1A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mea PREDICTED PROTEIN

(Acinetobacter
nosocomialis) 		PF00561
(Abhydrolase_1) 		4 TRP A  95
LEU A 119
GLY A 118
LYS A 259
 None
 1.13A 1ya4C-4meaA:
12.2		 1ya4C-4meaA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8v ALGINATE
BIOSYNTHESIS PROTEIN
ALGJ

(Pseudomonas
putida) 		PF16822
(ALGX) 		4 TRP A 193
PRO A 195
LEU A 187
GLY A 234
 None
 1.39A 1ya4C-4o8vA:
undetectable		 1ya4C-4o8vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7b CHOLINE KINASE

(Streptococcus
pneumoniae) 		PF01633
(Choline_kinase) 		4 PRO A 129
LEU A 163
GLY A 167
LYS A 239
 None
 1.13A 1ya4C-4r7bA:
undetectable		 1ya4C-4r7bA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE

(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		PF06722
(DUF1205) 		4 TRP A 191
PRO A  19
LEU A  17
GLY A 114
 None
 1.28A 1ya4C-4rihA:
undetectable		 1ya4C-4rihA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)

(Agrobacterium
fabrum) 		PF01547
(SBP_bac_1) 		4 PRO A 164
LEU A 158
GLY A 157
LYS A 176
 None
 1.31A 1ya4C-4rjzA:
undetectable		 1ya4C-4rjzA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr9 CALS8

(Micromonospora
echinospora) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 TRP A 282
PRO A 281
LEU A 277
GLY A 273
 None
None
TMP  A 503 (-4.6A)
TMP  A 503 (-3.7A)
 1.32A 1ya4C-4xr9A:
undetectable		 1ya4C-4xr9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		4 TRP B 736
PRO B 205
LEU B  35
GLY B  31
 None
 1.46A 1ya4C-4yg8B:
0.2		 1ya4C-4yg8B:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqz REV PROTEIN

(Borreliella
burgdorferi) 		PF03978
(Borrelia_REV) 		4 TRP A 116
PRO A 127
LEU A 129
GLY A 137
 None
 1.39A 1ya4C-5eqzA:
undetectable		 1ya4C-5eqzA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 4 TRP B 303
PRO B 305
LEU B 301
GLY B 297
 None
 1.34A 1ya4C-5f8uB:
undetectable		 1ya4C-5f8uB:
19.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		4 PRO A 342
LEU A 349
GLY A 352
LYS A 395
 None
 1.40A 1ya4C-5fv4A:
66.5		 1ya4C-5fv4A:
78.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		4 TRP A 339
PRO A 342
LEU A 349
GLY A 352
 None
 0.74A 1ya4C-5fv4A:
66.5		 1ya4C-5fv4A:
78.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		4 TRP A 147
PRO A 144
LEU A 173
GLY A 176
 None
 1.40A 1ya4C-5hosA:
undetectable		 1ya4C-5hosA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5klf CARBOHYDRATE BINDING
MODULE E1

(uncultured
bacterium) 		no annotation 4 PRO A  58
LEU A  79
GLY A  77
LYS A  35
 None
 1.38A 1ya4C-5klfA:
undetectable		 1ya4C-5klfA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		4 TRP A  45
PRO A  44
LEU A 624
GLY A 594
 None
 1.36A 1ya4C-5mqmA:
undetectable		 1ya4C-5mqmA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Sulfolobus
solfataricus) 		no annotation 4 TRP A  62
PRO A  63
LEU A  59
GLY A  58
 None
 1.42A 1ya4C-5n2pA:
undetectable		 1ya4C-5n2pA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 TRP A  80
PRO A  53
LEU A  48
GLY A 304
 None
 1.38A 1ya4C-5ujzA:
undetectable		 1ya4C-5ujzA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6t HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 TRP A  84
PRO A  58
LEU A  54
GLY A 303
 None
 1.25A 1ya4C-5w6tA:
undetectable		 1ya4C-5w6tA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 4 TRP A 407
PRO A 409
LEU A 405
GLY A 401
 None
PEG  A1215 ( 4.6A)
OLA  A1211 ( 4.6A)
OLA  A1211 (-3.6A)
 1.46A 1ya4C-5wivA:
0.9		 1ya4C-5wivA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US5

(Toxoplasma
gondii) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 TRP C 251
PRO C 247
LEU C  43
GLY C  44
 None
 1.40A 1ya4C-5xxuC:
undetectable		 1ya4C-5xxuC:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A

(Escherichia
coli;
Homo sapiens) 		no annotation 4 TRP A 246
PRO A 248
LEU A 244
GLY A 240
 None
CLR  A1202 (-4.1A)
None
None
 1.47A 1ya4C-6aqfA:
0.5		 1ya4C-6aqfA:
11.18