SIMILAR PATTERNS OF AMINO ACIDS FOR 1YA4_B_CTXB2_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		4 LEU A 158
PRO A 258
ILE A 245
LEU A 236
 None
 1.14A 1ya4B-1a2oA:
3.2		 1ya4B-1a2oA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0z PROTEIN
(PHOSPHOGLUCOSE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00342
(PGI) 		4 LEU A 127
PRO A 213
ILE A 134
LEU A 132
 None
 1.04A 1ya4B-1b0zA:
0.8		 1ya4B-1b0zA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dll TETANUS TOXIN

(Clostridium
tetani) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 LEU A 889
PRO A 910
ILE A 934
LEU A1072
 None
 1.04A 1ya4B-1dllA:
undetectable		 1ya4B-1dllA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 LEU A1164
PRO A1104
ILE A1100
LEU A1098
 None
 1.10A 1ya4B-1f20A:
undetectable		 1ya4B-1f20A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 LEU A 330
PRO A 367
ILE A 374
LEU A 375
 None
 1.11A 1ya4B-1jqoA:
0.9		 1ya4B-1jqoA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0x METHIONINE
AMINOPEPTIDASE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24) 		4 LEU A 198
PRO A 208
ILE A 241
LEU A 204
 None
 1.10A 1ya4B-1o0xA:
undetectable		 1ya4B-1o0xA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 LEU 1  29
PRO 1  82
ILE 1 275
LEU 1 274
 None
 1.05A 1ya4B-1poy1:
0.8		 1ya4B-1poy1:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 LEU A 121
PRO A  89
ILE A  83
LEU A  84
 None
 1.03A 1ya4B-1q20A:
0.5		 1ya4B-1q20A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 LEU A 131
PRO A 168
ILE A 163
LEU A 164
 None
 1.09A 1ya4B-1w6jA:
0.0		 1ya4B-1w6jA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		4 LEU B 265
PRO B 280
ILE B 276
LEU B 244
 None
 1.04A 1ya4B-1zunB:
undetectable		 1ya4B-1zunB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 LEU A 261
PRO A 206
ILE A 341
LEU A 202
 None
 1.04A 1ya4B-2abjA:
undetectable		 1ya4B-2abjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d86 VAV-3 PROTEIN

(Homo sapiens) 		PF11971
(CAMSAP_CH) 		4 LEU A  18
PRO A 137
ILE A 116
LEU A 119
 None
 1.05A 1ya4B-2d86A:
undetectable		 1ya4B-2d86A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		4 LEU A 400
PRO A 407
ILE A 364
LEU A  26
 None
 1.13A 1ya4B-2dkjA:
undetectable		 1ya4B-2dkjA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgs PUTATIVE PERIPLASMIC
PROTEIN

(Campylobacter
jejuni) 		PF04264
(YceI) 		4 LEU A 155
PRO A  60
ILE A  56
LEU A  68
 None
 1.01A 1ya4B-2fgsA:
undetectable		 1ya4B-2fgsA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frg TREM-LIKE
TRANSCRIPT-1

(Homo sapiens) 		no annotation 4 LEU P  87
PRO P  23
ILE P 114
LEU P 115
 None
 1.11A 1ya4B-2frgP:
undetectable		 1ya4B-2frgP:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2him L-ASPARAGINASE 1

(Escherichia
coli) 		PF00710
(Asparaginase) 		4 LEU A  35
PRO A  26
ILE A  15
LEU A 121
 None
 0.86A 1ya4B-2himA:
2.0		 1ya4B-2himA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqm GLUTATHIONE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 438
PRO A 380
ILE A 448
LEU A 449
 None
 1.07A 1ya4B-2hqmA:
undetectable		 1ya4B-2hqmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 277
PRO A 205
ILE A 164
LEU A 224
 None
 1.10A 1ya4B-2iwiA:
undetectable		 1ya4B-2iwiA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 651
PRO A 622
ILE A 615
LEU A 616
 None
 0.99A 1ya4B-2jkmA:
undetectable		 1ya4B-2jkmA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldy ORF1 CODES FOR A 40
KDA PRODUCT

(Homo sapiens) 		PF02994
(Transposase_22)
PF17490
(Tnp_22_dsRBD) 		4 LEU A 158
PRO A 164
ILE A 181
LEU A 178
 None
 1.05A 1ya4B-2ldyA:
undetectable		 1ya4B-2ldyA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		4 LEU A  94
PRO A  80
ILE A  75
LEU A  74
 SAH  A 301 ( 4.9A)
None
None
None
 1.10A 1ya4B-2pbfA:
undetectable		 1ya4B-2pbfA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa5 FILAMIN-B

(Homo sapiens) 		PF00307
(CH) 		4 LEU A  53
PRO A 126
ILE A 118
LEU A 117
 None
 0.87A 1ya4B-2wa5A:
undetectable		 1ya4B-2wa5A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv5 YJEQ PROTEIN

(Aquifex
aeolicus) 		PF03193
(RsgA_GTPase) 		4 LEU A 163
PRO A 224
ILE A 181
LEU A 185
 None
 0.86A 1ya4B-2yv5A:
1.2		 1ya4B-2yv5A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		4 LEU A  17
PRO A 260
ILE A 300
LEU A 297
 None
 1.06A 1ya4B-2yy5A:
undetectable		 1ya4B-2yy5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 LEU B 177
PRO B 162
ILE B 119
LEU B 106
 None
 1.06A 1ya4B-3al0B:
undetectable		 1ya4B-3al0B:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjq PHAGE-RELATED
PROTEIN

(Bordetella
bronchiseptica) 		PF03864
(Phage_cap_E) 		4 LEU A 131
PRO A 176
ILE A 307
LEU A 306
 None
 0.89A 1ya4B-3bjqA:
undetectable		 1ya4B-3bjqA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnh UNCHARACTERIZED
PROTEIN ATU2129

(Agrobacterium
fabrum) 		PF13883
(Pyrid_oxidase_2) 		4 LEU A 233
PRO A  63
ILE A 214
LEU A 224
 None
 1.04A 1ya4B-3dnhA:
undetectable		 1ya4B-3dnhA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		4 LEU A 393
PRO A  43
ILE A 128
LEU A 131
 None
 0.79A 1ya4B-3ed4A:
undetectable		 1ya4B-3ed4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 654
PRO A 625
ILE A 618
LEU A 619
 None
 0.99A 1ya4B-3fzpA:
undetectable		 1ya4B-3fzpA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		4 LEU A 160
PRO A 168
ILE A 173
LEU A 177
 None
 0.98A 1ya4B-3h9pA:
undetectable		 1ya4B-3h9pA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcj PEPTIDE METHIONINE
SULFOXIDE REDUCTASE

(Xanthomonas
campestris) 		PF01641
(SelR) 		4 LEU A 131
PRO A  37
ILE A 100
LEU A 109
 None
 1.02A 1ya4B-3hcjA:
undetectable		 1ya4B-3hcjA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoc FILAMIN-A

(Homo sapiens) 		PF00307
(CH) 		4 LEU A  80
PRO A 153
ILE A 145
LEU A 144
 None
 0.85A 1ya4B-3hocA:
undetectable		 1ya4B-3hocA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilw DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis) 		PF00521
(DNA_topoisoIV) 		4 LEU A 205
PRO A 167
ILE A 373
LEU A 370
 None
 0.85A 1ya4B-3ilwA:
undetectable		 1ya4B-3ilwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I

(Yersinia pestis) 		PF00710
(Asparaginase) 		4 LEU A  35
PRO A  26
ILE A  15
LEU A 121
 None
 0.90A 1ya4B-3ntxA:
undetectable		 1ya4B-3ntxA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oi8 UNCHARACTERIZED
PROTEIN

(Neisseria
meningitidis) 		PF00571
(CBS) 		4 LEU A  73
PRO A 120
ILE A 128
LEU A 125
 GOL  A   1 (-4.1A)
None
None
None
 1.00A 1ya4B-3oi8A:
undetectable		 1ya4B-3oi8A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qum PROSTATE-SPECIFIC
ANTIGEN

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU P  53
PRO P 111
ILE P 242
LEU P 105
 None
 1.11A 1ya4B-3qumP:
undetectable		 1ya4B-3qumP:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnx PAPAIN

(Carica papaya) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 LEU A 309
PRO A 316
ILE A 232
LEU A 228
 None
 1.09A 1ya4B-3tnxA:
undetectable		 1ya4B-3tnxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 LEU A 361
PRO A 410
ILE A 420
LEU A 417
 None
 1.08A 1ya4B-4aioA:
undetectable		 1ya4B-4aioA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 4 LEU A 416
PRO A 411
ILE A 463
LEU A 404
 None
IOD  A1721 ( 4.8A)
None
None
 0.99A 1ya4B-4aw7A:
undetectable		 1ya4B-4aw7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7l FILAMIN-B

(Homo sapiens) 		PF00307
(CH)
PF00630
(Filamin) 		4 LEU A  53
PRO A 126
ILE A 118
LEU A 117
 None
 0.91A 1ya4B-4b7lA:
undetectable		 1ya4B-4b7lA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01369
(Sec7)
PF16453
(IQ_SEC7_PH) 		4 LEU A 663
PRO A 641
ILE A 703
LEU A 705
 None
 1.11A 1ya4B-4c0aA:
undetectable		 1ya4B-4c0aA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		4 LEU A 292
PRO A  91
ILE A 304
LEU A 303
 None
 1.12A 1ya4B-4c1nA:
undetectable		 1ya4B-4c1nA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 5

(Saccharomyces
cerevisiae) 		PF10483
(Elong_Iki1) 		4 LEU B  38
PRO B   8
ILE B  15
LEU B  16
 None
 1.07A 1ya4B-4ejsB:
undetectable		 1ya4B-4ejsB:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ely DNA GYRASE SUBUNIT A

(Shigella
flexneri) 		PF00521
(DNA_topoisoIV) 		4 LEU A 474
PRO A 392
ILE A 458
LEU A 461
 None
 1.02A 1ya4B-4elyA:
undetectable		 1ya4B-4elyA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		4 LEU A  52
PRO A 213
ILE A  28
LEU A  56
 None
 1.10A 1ya4B-4f3eA:
undetectable		 1ya4B-4f3eA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		4 LEU A 191
PRO A  75
ILE A 107
LEU A  94
 None
 1.02A 1ya4B-4fajA:
undetectable		 1ya4B-4fajA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		4 LEU A1123
PRO A 739
ILE A 762
LEU A 765
 None
 1.13A 1ya4B-4fwtA:
undetectable		 1ya4B-4fwtA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE

(Trichormus
variabilis) 		PF00171
(Aldedh) 		4 LEU A 179
PRO A 100
ILE A 145
LEU A 148
 None
 1.07A 1ya4B-4h7nA:
undetectable		 1ya4B-4h7nA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Flavobacterium
johnsoniae) 		PF01884
(PcrB) 		4 LEU A 103
PRO A  87
ILE A 112
LEU A 111
 None
PGE  A 302 ( 3.2A)
None
None
 1.02A 1ya4B-4jejA:
undetectable		 1ya4B-4jejA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwo PHOSPHATE BINDING
PROTEIN

(Planctopirus
limnophila) 		PF12727
(PBP_like) 		4 LEU A 160
PRO A 181
ILE A 145
LEU A 235
 None
 0.81A 1ya4B-4jwoA:
undetectable		 1ya4B-4jwoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 LEU A 588
PRO A 409
ILE A 554
LEU A 551
 None
 1.03A 1ya4B-4kf7A:
undetectable		 1ya4B-4kf7A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 4 LEU H 245
PRO H 181
ILE H  59
LEU H  62
 None
 1.09A 1ya4B-4l0oH:
undetectable		 1ya4B-4l0oH:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lna PURINE NUCLEOSIDE
PHOSPHORYLASE

(Spirosoma
linguale) 		PF01048
(PNP_UDP_1) 		4 LEU A 163
PRO A  20
ILE A 268
LEU A 271
 None
 1.13A 1ya4B-4lnaA:
undetectable		 1ya4B-4lnaA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		4 LEU A 541
PRO A 249
ILE A 556
LEU A 559
 None
 1.04A 1ya4B-4mzdA:
1.8		 1ya4B-4mzdA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nb5 DNA BINDING PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A  41
PRO A  99
ILE A  77
LEU A  76
 None
 1.01A 1ya4B-4nb5A:
undetectable		 1ya4B-4nb5A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR

(Bifidobacterium
animalis) 		PF13377
(Peripla_BP_3) 		4 LEU A  96
PRO A 166
ILE A 316
LEU A 313
 None
 0.99A 1ya4B-4o5aA:
2.1		 1ya4B-4o5aA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 722
PRO A 753
ILE A 740
LEU A 757
 None
 1.14A 1ya4B-4oliA:
undetectable		 1ya4B-4oliA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR

(Escherichia
coli) 		PF00392
(GntR)
PF07729
(FCD) 		4 LEU A 215
PRO A  75
ILE A  85
LEU A  82
 None
 0.83A 1ya4B-4p9fA:
undetectable		 1ya4B-4p9fA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG

(Homo sapiens) 		PF08514
(STAG)
no annotation 		4 LEU A 825
PRO B 376
ILE A 794
LEU A 795
 None
 0.95A 1ya4B-4pjuA:
undetectable		 1ya4B-4pjuA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ric FANCONI-ASSOCIATED
NUCLEASE 1

(Homo sapiens) 		PF08774
(VRR_NUC) 		4 LEU A 571
PRO A 541
ILE A 548
LEU A 549
 None
 1.08A 1ya4B-4ricA:
2.5		 1ya4B-4ricA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		4 LEU A 393
PRO A 348
ILE A 380
LEU A 381
 None
 0.98A 1ya4B-4s38A:
undetectable		 1ya4B-4s38A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		4 LEU A 180
PRO A 162
ILE A 105
LEU A 166
 None
 1.03A 1ya4B-4us5A:
undetectable		 1ya4B-4us5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB

(Burkholderia
cenocepacia) 		PF00155
(Aminotran_1_2) 		4 LEU A 380
PRO A 184
ILE A 369
LEU A  31
 None
 0.97A 1ya4B-4wd2A:
undetectable		 1ya4B-4wd2A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 358
PRO A 271
ILE A 258
LEU A 256
 None
 0.85A 1ya4B-4wyrA:
undetectable		 1ya4B-4wyrA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgz ANTIZYME INHIBITOR 1

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 LEU A 212
PRO A 272
ILE A 268
LEU A 232
 None
 0.88A 1ya4B-4zgzA:
undetectable		 1ya4B-4zgzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ax0 RHODOPSIN I

(Acetabularia
acetabulum) 		PF01036
(Bac_rhodopsin) 		4 LEU A  98
PRO A 189
ILE A 182
LEU A 181
 None
RET  A 301 (-4.1A)
None
None
 0.92A 1ya4B-5ax0A:
undetectable		 1ya4B-5ax0A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv3 M7GPPPX
DIPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		4 LEU A 233
PRO A 262
ILE A 294
LEU A 291
 None
M7G  A 401 (-4.6A)
None
None
 1.12A 1ya4B-5bv3A:
undetectable		 1ya4B-5bv3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 LEU A 486
PRO A 435
ILE A 505
LEU A 472
 None
 1.04A 1ya4B-5c0yA:
undetectable		 1ya4B-5c0yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		4 LEU A 278
PRO A 418
ILE A 289
LEU A 288
 None
 1.09A 1ya4B-5c2iA:
undetectable		 1ya4B-5c2iA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A 503
PRO A 733
ILE A 512
LEU A 456
 None
 1.09A 1ya4B-5cioA:
undetectable		 1ya4B-5cioA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 LEU A 272
PRO A  91
ILE A  98
LEU A  99
 None
 1.01A 1ya4B-5d6bA:
undetectable		 1ya4B-5d6bA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e04 NUCLEOPROTEIN

(Andes
orthohantavirus) 		PF00846
(Hanta_nucleocap) 		4 LEU A 205
PRO A 325
ILE A 284
LEU A 294
 None
 1.01A 1ya4B-5e04A:
undetectable		 1ya4B-5e04A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU B 359
PRO B 272
ILE B 259
LEU B 257
 None
 0.86A 1ya4B-5f38B:
undetectable		 1ya4B-5f38B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq2 SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF14732
(UAE_UbL) 		4 LEU B 506
PRO B 478
ILE B 530
LEU B 517
 MLZ  B 505 ( 4.2A)
None
None
None
 1.12A 1ya4B-5fq2B:
undetectable		 1ya4B-5fq2B:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvi UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Danio rerio) 		PF00443
(UCH) 		4 LEU A 310
PRO A 252
ILE A 319
LEU A 247
 None
 1.11A 1ya4B-5gviA:
undetectable		 1ya4B-5gviA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0r VP4 PROTEIN

(Cypovirus 1) 		no annotation 4 LEU G 175
PRO G   6
ILE G  52
LEU G  56
 None
 1.12A 1ya4B-5h0rG:
undetectable		 1ya4B-5h0rG:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu7 PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		4 LEU A3082
PRO A3092
ILE A2891
LEU A2894
 None
 1.14A 1ya4B-5hu7A:
undetectable		 1ya4B-5hu7A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idb NATTERIN-3

(Crassostrea
gigas) 		no annotation 4 LEU B  48
PRO B  41
ILE B 111
LEU B  28
 BMA  B1001 ( 4.9A)
None
None
None
 1.13A 1ya4B-5idbB:
undetectable		 1ya4B-5idbB:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jge APE1 PROPEPTIDE
AUTOPHAGY-RELATED
PROTEIN 19

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 170
PRO C   0
ILE C   7
LEU C   8
 None
 1.09A 1ya4B-5jgeA:
undetectable		 1ya4B-5jgeA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 LEU A 350
PRO A 355
ILE A 280
LEU A 217
 None
 1.04A 1ya4B-5jouA:
undetectable		 1ya4B-5jouA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF14533
(USP7_C2) 		4 LEU A 232
PRO A 399
ILE A 320
LEU A 238
 None
 1.12A 1ya4B-5jtvA:
undetectable		 1ya4B-5jtvA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kl0 PHOSPHOGLUCOMUTASE

(Xanthomonas
citri) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A 444
PRO A 301
ILE A 424
LEU A 435
 None
 1.10A 1ya4B-5kl0A:
1.2		 1ya4B-5kl0A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 LEU A 139
PRO A  91
ILE A  98
LEU A  99
 None
 1.06A 1ya4B-5l9wA:
undetectable		 1ya4B-5l9wA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		4 LEU A 191
PRO A  92
ILE A 145
LEU A 143
 None
 0.99A 1ya4B-5lq4A:
undetectable		 1ya4B-5lq4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3c DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A1080
PRO A1100
ILE A1086
LEU A1085
 None
 1.13A 1ya4B-5m3cA:
undetectable		 1ya4B-5m3cA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 LEU A 889
PRO A 910
ILE A 934
LEU A1072
 None
 1.09A 1ya4B-5n0cA:
undetectable		 1ya4B-5n0cA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nno ALDEHYDE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00171
(Aldedh) 		4 LEU A  49
PRO A   9
ILE A 134
LEU A 131
 None
 1.09A 1ya4B-5nnoA:
0.6		 1ya4B-5nnoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0x PUTATIVE FERRIC
REDUCTASE

(Cylindrospermum
stagnale) 		PF08022
(FAD_binding_8)
PF08030
(NAD_binding_6) 		4 LEU A 533
PRO A 467
ILE A 550
LEU A 547
 None
 0.93A 1ya4B-5o0xA:
undetectable		 1ya4B-5o0xA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzk GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		PF00535
(Glycos_transf_2) 		4 LEU C 162
PRO C  71
ILE C   6
LEU C  79
 None
UDP  C 401 (-3.5A)
None
None
 1.13A 1ya4B-5tzkC:
undetectable		 1ya4B-5tzkC:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 191
PRO A 132
ILE A 255
LEU A 140
 None
 0.98A 1ya4B-5uibA:
2.2		 1ya4B-5uibA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		4 LEU A 130
PRO A  27
ILE A  95
LEU A  98
 None
 1.08A 1ya4B-5ujsA:
undetectable		 1ya4B-5ujsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1d PROTOCADHERIN-15

(Mus musculus) 		no annotation 4 LEU A 735
PRO A 701
ILE A 786
LEU A 766
 None
 1.12A 1ya4B-5w1dA:
undetectable		 1ya4B-5w1dA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w75 ELONGATION FACTOR TU

(Thermotoga
neapolitana) 		no annotation 4 LEU A 157
PRO A 129
ILE A  18
LEU A 104
 None
 1.08A 1ya4B-5w75A:
undetectable		 1ya4B-5w75A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a0z HEMAGGLUTININ,ENVELO
PE GLYCOPROTEIN

(Human
immunodeficiency
virus 1;
Influenza A
virus) 		no annotation 4 LEU A  70
PRO A  58
ILE A 267
LEU A 112
 None
 1.13A 1ya4B-6a0zA:
undetectable		 1ya4B-6a0zA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao1 BETA-LACTAMASE
DOMAIN PROTEIN

(Paraburkholderia
phymatum) 		PF00753
(Lactamase_B) 		4 LEU A 212
PRO A 207
ILE A 121
LEU A 184
 None
 1.08A 1ya4B-6ao1A:
undetectable		 1ya4B-6ao1A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Mus musculus) 		no annotation 4 LEU B 510
PRO B 501
ILE B 474
LEU B 477
 None
 1.08A 1ya4B-6bcqB:
1.3		 1ya4B-6bcqB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD

(Bacillus
thuringiensis) 		no annotation 4 LEU A  60
PRO A  30
ILE A  10
LEU A   9
 None
 1.14A 1ya4B-6bwcA:
1.2		 1ya4B-6bwcA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 117
PRO A 477
ILE A  37
LEU A  33
 EGY  A 801 (-4.8A)
None
None
None
 1.10A 1ya4B-6c26A:
undetectable		 1ya4B-6c26A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 4 LEU A 131
PRO A  27
ILE A  96
LEU A  99
 None
 1.14A 1ya4B-6cn1A:
0.7		 1ya4B-6cn1A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN

(Homo sapiens) 		no annotation 4 LEU A 508
PRO A 482
ILE A 550
LEU A 486
 None
 1.02A 1ya4B-6ei1A:
undetectable		 1ya4B-6ei1A:
8.45