SIMILAR PATTERNS OF AMINO ACIDS FOR 1YA4_B_CTXB2_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aos ARGININOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 GLY A 200
VAL A 211
SER A  42
LEU A 216
LEU A  49
 None
 1.12A 1ya4B-1aosA:
undetectable		 1ya4B-1aosA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atj PEROXIDASE C1A

(Armoracia
rusticana) 		PF00141
(peroxidase) 		5 PHE A 277
GLY A 114
GLY A 113
LEU A  37
LEU A  26
 None
None
None
HEM  A 350 ( 4.7A)
None
 1.07A 1ya4B-1atjA:
undetectable		 1ya4B-1atjA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyd CARBONYL REDUCTASE

(Mus musculus) 		PF13561
(adh_short_C2) 		5 GLY A  16
VAL A  24
LEU A  44
LEU A  47
LEU A  61
 NDP  A 245 (-3.7A)
None
None
None
NDP  A 245 (-3.8A)
 1.30A 1ya4B-1cydA:
3.4		 1ya4B-1cydA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea6 PMS1 PROTEIN HOMOLOG
2

(Homo sapiens) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		5 GLY A  62
VAL A 159
LEU A  35
SER A  34
LEU A 114
 None
 1.28A 1ya4B-1ea6A:
undetectable		 1ya4B-1ea6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 GLY A 109
GLY A 110
LEU A  28
SER A  29
LEU A  85
 2CP  A 270 ( 3.8A)
2CP  A 270 (-3.4A)
None
None
None
 1.10A 1ya4B-1ef9A:
undetectable		 1ya4B-1ef9A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 GLY A 110
LEU A  28
SER A  29
LEU A  85
LEU A  71
 2CP  A 270 (-3.4A)
None
None
None
None
 1.17A 1ya4B-1ef9A:
undetectable		 1ya4B-1ef9A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		5 GLY A  83
GLY A  84
SER A 155
LEU A 205
HIS A 282
 EPE  A 455 (-3.3A)
EPE  A 455 (-3.3A)
EPE  A 455 (-1.4A)
None
EPE  A 455 (-4.0A)
 0.44A 1ya4B-1evqA:
4.1		 1ya4B-1evqA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 GLY A  67
VAL A 143
LEU A 187
LEU A  71
LEU A 144
 None
 1.17A 1ya4B-1ezvA:
undetectable		 1ya4B-1ezvA:
24.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		6 GLY A 122
GLY A 123
VAL A 296
LEU A 127
LEU A 297
HIS A 449
 None
 1.15A 1ya4B-1gz7A:
36.5		 1ya4B-1gz7A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		6 GLY A 123
SER A 209
VAL A 296
LEU A 127
LEU A 297
HIS A 449
 None
 1.21A 1ya4B-1gz7A:
36.5		 1ya4B-1gz7A:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 170
VAL A 210
LEU A 197
LEU A 201
LEU A 229
 None
 1.15A 1ya4B-1qorA:
undetectable		 1ya4B-1qorA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlm PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		5 VAL A 161
SER A 150
LEU A 153
LEU A  97
LEU A 165
 None
GOL  A 804 (-3.0A)
None
None
None
 1.35A 1ya4B-1rlmA:
undetectable		 1ya4B-1rlmA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00378
(ECH_1) 		5 GLY A 112
GLY A 111
LEU A  28
SER A  29
LEU A  66
 None
 1.14A 1ya4B-1sg4A:
undetectable		 1ya4B-1sg4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		5 GLY A 117
VAL A  77
SER A  50
LEU A 166
LEU A  57
 None
 1.01A 1ya4B-1txoA:
undetectable		 1ya4B-1txoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE

(Thermus
thermophilus) 		PF01761
(DHQ_synthase) 		5 GLY A 170
VAL A 251
LEU A 186
LEU A 255
HIS A 177
 None
 1.13A 1ya4B-1ujnA:
undetectable		 1ya4B-1ujnA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 GLY A  32
VAL A 157
SER A 107
LEU A  28
HIS A  29
 None
 1.32A 1ya4B-1uwyA:
3.0		 1ya4B-1uwyA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 GLY A 206
VAL A 148
LEU A 122
SER A 123
LEU A 152
 None
None
None
AMP  A 700 ( 4.3A)
None
 1.26A 1ya4B-1v9pA:
2.5		 1ya4B-1v9pA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1) 		5 GLY A 107
GLY A 108
SER A 133
LEU A 112
HIS A 271
 None
None
None
None
LEU  A 301 (-3.4A)
 1.34A 1ya4B-1xqwA:
5.1		 1ya4B-1xqwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 VAL A1175
LEU A1157
LEU A1160
LEU A1140
LEU A1179
 None
 1.36A 1ya4B-1yguA:
undetectable		 1ya4B-1yguA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME

(Agrobacterium
tumefaciens) 		PF00206
(Lyase_1) 		5 PHE A  24
GLY A 332
VAL A 244
LEU A 335
LEU A 120
 None
 1.28A 1ya4B-2felA:
undetectable		 1ya4B-2felA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h9f HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF04303
(PrpF) 		5 GLY A  21
LEU A 107
SER A 108
LEU A  14
LEU A  74
 None
 1.15A 1ya4B-2h9fA:
undetectable		 1ya4B-2h9fA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		5 PHE A  50
GLY A 258
VAL A 226
LEU A 162
LEU A 181
 None
 1.32A 1ya4B-2i62A:
undetectable		 1ya4B-2i62A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		5 GLY A 552
GLY A 553
VAL A 518
LEU A 554
LEU A 242
 None
 1.05A 1ya4B-2nyfA:
undetectable		 1ya4B-2nyfA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		5 GLY A  92
GLY A  93
SER A 169
LEU A  22
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
 0.81A 1ya4B-2o7rA:
17.8		 1ya4B-2o7rA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 169
GLY A 170
VAL A 213
LEU A 196
LEU A 217
 None
 0.98A 1ya4B-2pp3A:
undetectable		 1ya4B-2pp3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)

(Candida
albicans) 		PF01380
(SIS) 		5 VAL A 473
LEU A 389
SER A 390
LEU A 385
LEU A 471
 None
 1.22A 1ya4B-2putA:
undetectable		 1ya4B-2putA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA

(-) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PHE A  99
GLY A 278
GLY A 279
LEU A 280
LEU A  68
 None
 1.16A 1ya4B-2qgyA:
undetectable		 1ya4B-2qgyA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj9 MIPZ

(Caulobacter
vibrioides) 		PF09140
(MipZ) 		5 GLY A 144
SER A 160
VAL A 183
SER A 136
LEU A 203
 None
 1.30A 1ya4B-2xj9A:
2.8		 1ya4B-2xj9A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 PHE A 136
GLY A 132
VAL A  65
LEU A  58
LEU A  60
 None
 1.05A 1ya4B-2xvgA:
undetectable		 1ya4B-2xvgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbm PROTEIN-TYROSINE-PHO
SPHATASE

(Shewanella sp.) 		PF00149
(Metallophos) 		5 GLY A 208
GLY A 209
VAL A 300
SER A 262
LEU A 295
 None
 1.00A 1ya4B-2zbmA:
undetectable		 1ya4B-2zbmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 GLY A 369
GLY A 368
VAL A 279
LEU A 377
LEU A 283
 None
 1.28A 1ya4B-3abbA:
undetectable		 1ya4B-3abbA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		5 GLY A   6
GLY A   5
VAL A 228
SER A 347
LEU A 321
 None
 1.17A 1ya4B-3alfA:
undetectable		 1ya4B-3alfA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnh UNCHARACTERIZED
PROTEIN ATU2129

(Agrobacterium
fabrum) 		PF13883
(Pyrid_oxidase_2) 		5 GLY A 109
VAL A  89
LEU A 147
MET A  81
LEU A  42
 None
 1.07A 1ya4B-3dnhA:
undetectable		 1ya4B-3dnhA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		5 GLY A 164
LEU A 125
LEU A 323
LEU A 133
LEU A 316
 None
 0.76A 1ya4B-3e3pA:
undetectable		 1ya4B-3e3pA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1b TETR-LIKE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		5 GLY A 161
LEU A 184
LEU A 187
LEU A 131
LEU A 139
 None
 1.30A 1ya4B-3f1bA:
undetectable		 1ya4B-3f1bA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Methanocaldococcus
jannaschii) 		PF00004
(AAA) 		5 GLY A 173
VAL A 338
LEU A 219
LEU A 220
LEU A 380
 ADP  A 439 (-4.0A)
None
ADP  A 439 (-4.0A)
None
None
 1.35A 1ya4B-3h4mA:
undetectable		 1ya4B-3h4mA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II

(Escherichia
coli) 		PF00294
(PfkB) 		5 GLY A 136
VAL A 148
LEU A 182
LEU A 139
HIS A 133
 None
 1.30A 1ya4B-3iq0A:
undetectable		 1ya4B-3iq0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A  89
GLY A  90
SER A 157
LEU A 192
HIS A 281
 None
 0.69A 1ya4B-3k6kA:
16.6		 1ya4B-3k6kA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A  89
GLY A  90
SER A 157
LEU A 206
HIS A 281
 None
 0.54A 1ya4B-3k6kA:
16.6		 1ya4B-3k6kA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		9 PHE A1101
GLY A1142
GLY A1143
SER A1221
VAL A1254
LEU A1358
MET A1364
LEU A1388
HIS A1468
 None
WW2  A 193 (-3.4A)
WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
None
None
None
None
None
 0.45A 1ya4B-3k9bA:
61.7		 1ya4B-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 GLY A   6
VAL A  35
LEU A   3
LEU A  39
LEU A 422
 None
 1.25A 1ya4B-3lscA:
2.3		 1ya4B-3lscA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2s NADPH-DEPENDENT
NITRO/FLAVIN
REDUCTASE

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		5 GLY A 136
VAL A 145
LEU A 142
LEU A 161
LEU A 149
 FMN  A 400 ( 3.6A)
None
None
None
None
 1.23A 1ya4B-3n2sA:
undetectable		 1ya4B-3n2sA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		5 GLY A 217
LEU A 250
LEU A 228
LEU A 191
LEU A 184
 None
 1.30A 1ya4B-3o75A:
2.9		 1ya4B-3o75A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oh8 NUCLEOSIDE-DIPHOSPHA
TE SUGAR EPIMERASE
(SULA FAMILY)

(Corynebacterium
glutamicum) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		5 GLY A 312
GLY A 313
VAL A 306
LEU A 317
LEU A 440
 None
 1.15A 1ya4B-3oh8A:
undetectable		 1ya4B-3oh8A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		5 PHE A 145
GLY A  14
LEU A  60
LEU A  59
LEU A 158
 None
 1.30A 1ya4B-3pl2A:
2.8		 1ya4B-3pl2A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN

(Salmonella
enterica) 		PF00291
(PALP) 		5 GLY B 233
GLY B 232
SER B 235
LEU B 304
LEU B 188
 7MN  B   2 (-3.7A)
7MN  B   2 ( 3.2A)
7MN  B   2 (-2.7A)
None
None
 1.10A 1ya4B-3pr2B:
undetectable		 1ya4B-3pr2B:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe7 URACIL PERMEASE

(Escherichia
coli) 		PF00860
(Xan_ur_permease) 		5 GLY A 308
GLY A 307
SER A  21
LEU A  58
LEU A  14
 None
 1.03A 1ya4B-3qe7A:
undetectable		 1ya4B-3qe7A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1

(Homo sapiens) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 VAL A 206
LEU A 181
LEU A 210
LEU A 108
LEU A 144
 None
 1.34A 1ya4B-3swlA:
undetectable		 1ya4B-3swlA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkn NUCLEOPORIN NUP82

(Saccharomyces
cerevisiae) 		no annotation 5 GLY A 202
GLY A 203
VAL A 317
LEU A 197
LEU A 327
 None
 1.11A 1ya4B-3tknA:
undetectable		 1ya4B-3tknA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		5 PHE A 741
GLY A 671
GLY A 672
LEU A 676
LEU A 666
 None
 1.33A 1ya4B-3ut2A:
undetectable		 1ya4B-3ut2A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vis ESTERASE

(Thermobifida
alba) 		PF12740
(Chlorophyllase2) 		5 GLY A 173
GLY A 174
VAL A 165
LEU A 139
LEU A 185
 None
 1.17A 1ya4B-3visA:
14.0		 1ya4B-3visA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		5 GLY A 124
GLY A 125
SER A 203
LEU A 126
HIS A 457
 None
 0.79A 1ya4B-3wmtA:
6.5		 1ya4B-3wmtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		5 GLY A 226
GLY A 227
LEU A 223
MET A 270
LEU A 231
 None
 1.22A 1ya4B-4ag4A:
undetectable		 1ya4B-4ag4A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		5 GLY A1360
SER A1282
VAL A1295
LEU A1289
LEU A1341
 None
 1.24A 1ya4B-4amcA:
2.1		 1ya4B-4amcA:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 134
GLY A 135
SER A 220
LEU A 355
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
PEG  A1555 (-4.6A)
None
 0.66A 1ya4B-4be9A:
37.0		 1ya4B-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 134
GLY A 135
SER A 220
SER A 309
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 1.01A 1ya4B-4be9A:
37.0		 1ya4B-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 135
SER A 220
SER A 311
LEU A 355
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
PEG  A1555 (-4.6A)
None
 0.81A 1ya4B-4be9A:
37.0		 1ya4B-4be9A:
32.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb0 LCC

(uncultured
bacterium) 		PF12695
(Abhydrolase_5) 		5 GLY A 169
GLY A 170
VAL A 161
LEU A 135
LEU A 181
 None
 1.16A 1ya4B-4eb0A:
13.9		 1ya4B-4eb0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 PHE A   9
GLY A 463
GLY A 464
LEU A 408
LEU A 211
 None
 1.14A 1ya4B-4g1pA:
2.7		 1ya4B-4g1pA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago maydis) 		PF08661
(Rep_fac-A_3) 		5 PHE A  74
GLY A  25
VAL A  96
LEU A  93
LEU A  13
 None
 1.21A 1ya4B-4gnxA:
undetectable		 1ya4B-4gnxA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i34 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Escherichia
coli) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 GLY A 249
GLY A 248
LEU A 116
LEU A 287
LEU A  88
 None
 1.09A 1ya4B-4i34A:
2.3		 1ya4B-4i34A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		5 GLY C  94
GLY C  93
VAL C 241
SER C 129
LEU C 284
 None
 1.14A 1ya4B-4ifdC:
undetectable		 1ya4B-4ifdC:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		5 GLY A  66
SER A 308
LEU A 161
SER A 160
LEU A 177
 None
 0.96A 1ya4B-4jccA:
undetectable		 1ya4B-4jccA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2j AMINOTRANSFERASE

(Streptomyces
lavendulae) 		PF00155
(Aminotran_1_2) 		5 GLY A 374
LEU A 337
LEU A 301
LEU A 359
HIS A 298
 None
 1.16A 1ya4B-4m2jA:
undetectable		 1ya4B-4m2jA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhl INTERLEUKIN-11

(Homo sapiens) 		PF07400
(IL11) 		5 GLY A 169
GLY A 170
LEU A 119
LEU A 178
HIS A  70
 None
None
None
None
ARF  A 203 (-3.6A)
 1.30A 1ya4B-4mhlA:
undetectable		 1ya4B-4mhlA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		5 SER A 180
VAL A  45
LEU A  28
LEU A 165
LEU A  42
 None
 1.34A 1ya4B-4muoA:
2.5		 1ya4B-4muoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou4 ALPHA/BETA HYDROLASE
FOLD-3 DOMAIN
PROTEIN

(Pseudomonas sp.
ECU1011) 		PF07859
(Abhydrolase_3) 		5 PHE A  83
GLY A  86
GLY A  87
LEU A  36
LEU A 100
 None
 1.34A 1ya4B-4ou4A:
16.8		 1ya4B-4ou4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B

(Drosophila
melanogaster) 		PF00079
(Serpin) 		5 PHE A  77
VAL A  20
LEU A 281
LEU A  65
LEU A 288
 None
 1.32A 1ya4B-4p0fA:
undetectable		 1ya4B-4p0fA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 VAL A 658
LEU A 722
LEU A 718
LEU A 603
LEU A 653
 None
 0.89A 1ya4B-4p6wA:
undetectable		 1ya4B-4p6wA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q80 SERINE PROTEASE 57

(Homo sapiens) 		PF00089
(Trypsin) 		5 PHE A  59
GLY A 196
VAL A 231
LEU A 106
LEU A 123
 None
 1.24A 1ya4B-4q80A:
undetectable		 1ya4B-4q80A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qan HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		no annotation 5 GLY A 188
VAL A 178
LEU A 135
SER A 136
LEU A 145
 None
 1.25A 1ya4B-4qanA:
undetectable		 1ya4B-4qanA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE

(Brucella
abortus) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A 333
GLY A 334
SER A 340
LEU A 335
LEU A 321
 None
 1.19A 1ya4B-4qgrA:
undetectable		 1ya4B-4qgrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		5 PHE A 296
GLY A 336
LEU A 332
LEU A  22
MET A 328
 None
 1.31A 1ya4B-4ufcA:
undetectable		 1ya4B-4ufcA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
BETA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		5 GLY B  82
GLY B  81
VAL B 271
SER B  74
LEU B  93
 None
 1.25A 1ya4B-4wvmB:
undetectable		 1ya4B-4wvmB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpf ANTIBODY FRAGMENT
LIGHT CHAIN-PROTEIN,
9D5-LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H   8
GLY H   9
LEU H  18
SER H  17
LEU H 115
 None
 1.32A 1ya4B-4xpfH:
undetectable		 1ya4B-4xpfH:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dj4 SESTRIN-2

(Homo sapiens) 		PF04636
(PA26) 		5 GLY A 360
GLY A 359
LEU A  96
LEU A  99
LEU A 200
 None
 1.26A 1ya4B-5dj4A:
undetectable		 1ya4B-5dj4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO

(Homo sapiens) 		PF12933
(FTO_NTD)
PF12934
(FTO_CTD) 		5 GLY A 498
VAL A 421
LEU A 439
LEU A 435
LEU A 418
 None
 1.03A 1ya4B-5f8pA:
undetectable		 1ya4B-5f8pA:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		6 PHE A  84
GLY A 125
GLY A 126
SER A 204
LEU A 340
HIS A 449
 None
 0.38A 1ya4B-5fv4A:
63.3		 1ya4B-5fv4A:
78.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00466
(Ribosomal_L10) 		5 GLY i 257
GLY i 256
VAL i 250
LEU i  82
LEU i 273
 None
 1.30A 1ya4B-5gafi:
2.9		 1ya4B-5gafi:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A 108
GLY A 109
SER A 188
LEU A 239
HIS A 317
 TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
 0.52A 1ya4B-5hc4A:
3.6		 1ya4B-5hc4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdj NFRA1

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		5 GLY A 136
VAL A 145
LEU A 142
LEU A 161
LEU A 149
 FMN  A 400 (-3.6A)
None
None
None
None
 1.26A 1ya4B-5hdjA:
undetectable		 1ya4B-5hdjA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A  13
GLY A  14
VAL A 209
LEU A  90
LEU A  10
 FAD  A 702 (-3.6A)
FAD  A 702 (-3.9A)
None
None
None
 1.15A 1ya4B-5i68A:
undetectable		 1ya4B-5i68A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijj SPX DOMAIN

(Chaetomium
thermophilum) 		PF03105
(SPX) 		5 VAL A 159
SER A 107
LEU A 112
LEU A  76
LEU A 163
 None
 1.26A 1ya4B-5ijjA:
undetectable		 1ya4B-5ijjA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		5 PHE A 233
GLY A 172
GLY A 173
LEU A 146
LEU A 211
 None
 0.85A 1ya4B-5inrA:
undetectable		 1ya4B-5inrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00291
(PALP) 		5 GLY B 238
GLY B 237
SER B 240
LEU B 309
LEU B 192
 LLP  B  91 ( 3.6A)
LLP  B  91 ( 3.6A)
LLP  B  91 ( 2.6A)
None
None
 1.13A 1ya4B-5kinB:
2.4		 1ya4B-5kinB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku7 TIR-NB-LRR TYPE
RESISTANCE PROTEIN
RPV1

(Vitis
rotundifolia) 		PF01582
(TIR) 		5 SER A  80
LEU A  71
LEU A  70
LEU A 108
HIS A 110
 None
 1.28A 1ya4B-5ku7A:
undetectable		 1ya4B-5ku7A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1t PENTALENOLACTONE
SYNTHASE

(Streptomyces
arenae) 		PF00067
(p450) 		5 SER A 141
VAL A 396
LEU A 371
LEU A 243
LEU A 373
 None
 1.29A 1ya4B-5l1tA:
undetectable		 1ya4B-5l1tA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 GLY A 501
VAL A 460
LEU A 510
SER A 511
LEU A 540
 None
 1.36A 1ya4B-5n4lA:
undetectable		 1ya4B-5n4lA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n57 SUPEROXIDE DISMUTASE

(Staphylococcus
aureus) 		no annotation 5 GLY A  76
GLY A  75
VAL A  43
SER A  52
LEU A  48
 None
 1.15A 1ya4B-5n57A:
undetectable		 1ya4B-5n57A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 GLY B 873
GLY B 874
LEU B 891
SER B 892
LEU B 866
 None
 1.12A 1ya4B-5nd1B:
undetectable		 1ya4B-5nd1B:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nux CHROMATE REDUCTASE

(Thermus
scotoductus) 		no annotation 5 PHE A 223
GLY A 292
LEU A 306
LEU A  53
LEU A   4
 None
 0.97A 1ya4B-5nuxA:
undetectable		 1ya4B-5nuxA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Streptosporangium
roseum) 		no annotation 5 GLY A 276
GLY A 275
VAL A 239
LEU A 270
MET A 282
 None
 1.04A 1ya4B-5ocmA:
undetectable		 1ya4B-5ocmA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE

(Azospirillum
brasilense) 		no annotation 5 GLY A  12
VAL A 284
SER A   5
LEU A  11
LEU A 288
 None
 1.22A 1ya4B-5ovoA:
undetectable		 1ya4B-5ovoA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE

(Cupriavidus
necator) 		PF07167
(PhaC_N) 		5 GLY A 321
GLY A 322
VAL A 343
LEU A 345
LEU A 274
 None
 1.01A 1ya4B-5t6oA:
4.2		 1ya4B-5t6oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 5 PHE A 700
GLY A 630
GLY A 631
LEU A 635
LEU A 625
 None
 1.34A 1ya4B-5whsA:
undetectable		 1ya4B-5whsA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9v RYANODINE RECEPTOR 1

(Plutella
xylostella) 		no annotation 5 VAL A 187
LEU A  25
SER A  26
LEU A 176
LEU A  48
 None
 1.21A 1ya4B-5y9vA:
undetectable		 1ya4B-5y9vA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 5 GLY A 876
VAL A 792
LEU A 979
LEU A 976
LEU A 803
 None
 1.31A 1ya4B-6cnhA:
undetectable		 1ya4B-6cnhA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cyz HOMOSERINE KINASE

(Mycobacteroides
abscessus) 		no annotation 5 GLY A  80
GLY A  79
VAL A 130
LEU A 118
LEU A 131
 None
 1.27A 1ya4B-6cyzA:
undetectable		 1ya4B-6cyzA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm9 UDP-N-ACETYLGLUCOSAM
INE--DOLICHYL-PHOSPH
ATE
N-ACETYLGLUCOSAMINEP
HOSPHOTRANSFERASE

(Homo sapiens) 		no annotation 5 VAL A 370
LEU A 363
LEU A 366
LEU A 389
LEU A 371
 None
 1.29A 1ya4B-6fm9A:
undetectable		 1ya4B-6fm9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 5 GLY A  90
GLY A  91
SER A 169
LEU A  92
HIS A 421
 None
 0.81A 1ya4B-6g21A:
10.0		 1ya4B-6g21A:
10.78