SIMILAR PATTERNS OF AMINO ACIDS FOR 1YA4_B_CTXB2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aos ARGININOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 GLY A 200
VAL A 211
SER A  42
LEU A 216
LEU A  49
 None
 1.12A 1ya4B-1aosA:
undetectable		 1ya4B-1aosA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atj PEROXIDASE C1A

(Armoracia
rusticana) 		PF00141
(peroxidase) 		5 PHE A 277
GLY A 114
GLY A 113
LEU A  37
LEU A  26
 None
None
None
HEM  A 350 ( 4.7A)
None
 1.07A 1ya4B-1atjA:
undetectable		 1ya4B-1atjA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyd CARBONYL REDUCTASE

(Mus musculus) 		PF13561
(adh_short_C2) 		5 GLY A  16
VAL A  24
LEU A  44
LEU A  47
LEU A  61
 NDP  A 245 (-3.7A)
None
None
None
NDP  A 245 (-3.8A)
 1.30A 1ya4B-1cydA:
3.4		 1ya4B-1cydA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea6 PMS1 PROTEIN HOMOLOG
2

(Homo sapiens) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		5 GLY A  62
VAL A 159
LEU A  35
SER A  34
LEU A 114
 None
 1.28A 1ya4B-1ea6A:
undetectable		 1ya4B-1ea6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 GLY A 109
GLY A 110
LEU A  28
SER A  29
LEU A  85
 2CP  A 270 ( 3.8A)
2CP  A 270 (-3.4A)
None
None
None
 1.10A 1ya4B-1ef9A:
undetectable		 1ya4B-1ef9A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 GLY A 110
LEU A  28
SER A  29
LEU A  85
LEU A  71
 2CP  A 270 (-3.4A)
None
None
None
None
 1.17A 1ya4B-1ef9A:
undetectable		 1ya4B-1ef9A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		5 GLY A  83
GLY A  84
SER A 155
LEU A 205
HIS A 282
 EPE  A 455 (-3.3A)
EPE  A 455 (-3.3A)
EPE  A 455 (-1.4A)
None
EPE  A 455 (-4.0A)
 0.44A 1ya4B-1evqA:
4.1		 1ya4B-1evqA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 GLY A  67
VAL A 143
LEU A 187
LEU A  71
LEU A 144
 None
 1.17A 1ya4B-1ezvA:
undetectable		 1ya4B-1ezvA:
24.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		6 GLY A 122
GLY A 123
VAL A 296
LEU A 127
LEU A 297
HIS A 449
 None
 1.15A 1ya4B-1gz7A:
36.5		 1ya4B-1gz7A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		6 GLY A 123
SER A 209
VAL A 296
LEU A 127
LEU A 297
HIS A 449
 None
 1.21A 1ya4B-1gz7A:
36.5		 1ya4B-1gz7A:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 170
VAL A 210
LEU A 197
LEU A 201
LEU A 229
 None
 1.15A 1ya4B-1qorA:
undetectable		 1ya4B-1qorA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlm PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		5 VAL A 161
SER A 150
LEU A 153
LEU A  97
LEU A 165
 None
GOL  A 804 (-3.0A)
None
None
None
 1.35A 1ya4B-1rlmA:
undetectable		 1ya4B-1rlmA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00378
(ECH_1) 		5 GLY A 112
GLY A 111
LEU A  28
SER A  29
LEU A  66
 None
 1.14A 1ya4B-1sg4A:
undetectable		 1ya4B-1sg4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		5 GLY A 117
VAL A  77
SER A  50
LEU A 166
LEU A  57
 None
 1.01A 1ya4B-1txoA:
undetectable		 1ya4B-1txoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujn DEHYDROQUINATE
SYNTHASE

(Thermus
thermophilus) 		PF01761
(DHQ_synthase) 		5 GLY A 170
VAL A 251
LEU A 186
LEU A 255
HIS A 177
 None
 1.13A 1ya4B-1ujnA:
undetectable		 1ya4B-1ujnA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 GLY A  32
VAL A 157
SER A 107
LEU A  28
HIS A  29
 None
 1.32A 1ya4B-1uwyA:
3.0		 1ya4B-1uwyA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 GLY A 206
VAL A 148
LEU A 122
SER A 123
LEU A 152
 None
None
None
AMP  A 700 ( 4.3A)
None
 1.26A 1ya4B-1v9pA:
2.5		 1ya4B-1v9pA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1) 		5 GLY A 107
GLY A 108
SER A 133
LEU A 112
HIS A 271
 None
None
None
None
LEU  A 301 (-3.4A)
 1.34A 1ya4B-1xqwA:
5.1		 1ya4B-1xqwA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 VAL A1175
LEU A1157
LEU A1160
LEU A1140
LEU A1179
 None
 1.36A 1ya4B-1yguA:
undetectable		 1ya4B-1yguA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME

(Agrobacterium
tumefaciens) 		PF00206
(Lyase_1) 		5 PHE A  24
GLY A 332
VAL A 244
LEU A 335
LEU A 120
 None
 1.28A 1ya4B-2felA:
undetectable		 1ya4B-2felA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h9f HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF04303
(PrpF) 		5 GLY A  21
LEU A 107
SER A 108
LEU A  14
LEU A  74
 None
 1.15A 1ya4B-2h9fA:
undetectable		 1ya4B-2h9fA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		5 PHE A  50
GLY A 258
VAL A 226
LEU A 162
LEU A 181
 None
 1.32A 1ya4B-2i62A:
undetectable		 1ya4B-2i62A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		5 GLY A 552
GLY A 553
VAL A 518
LEU A 554
LEU A 242
 None
 1.05A 1ya4B-2nyfA:
undetectable		 1ya4B-2nyfA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		5 GLY A  92
GLY A  93
SER A 169
LEU A  22
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
 0.81A 1ya4B-2o7rA:
17.8		 1ya4B-2o7rA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 169
GLY A 170
VAL A 213
LEU A 196
LEU A 217
 None
 0.98A 1ya4B-2pp3A:
undetectable		 1ya4B-2pp3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)

(Candida
albicans) 		PF01380
(SIS) 		5 VAL A 473
LEU A 389
SER A 390
LEU A 385
LEU A 471
 None
 1.22A 1ya4B-2putA:
undetectable		 1ya4B-2putA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA

(-) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PHE A  99
GLY A 278
GLY A 279
LEU A 280
LEU A  68
 None
 1.16A 1ya4B-2qgyA:
undetectable		 1ya4B-2qgyA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj9 MIPZ

(Caulobacter
vibrioides) 		PF09140
(MipZ) 		5 GLY A 144
SER A 160
VAL A 183
SER A 136
LEU A 203
 None
 1.30A 1ya4B-2xj9A:
2.8		 1ya4B-2xj9A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 PHE A 136
GLY A 132
VAL A  65
LEU A  58
LEU A  60
 None
 1.05A 1ya4B-2xvgA:
undetectable		 1ya4B-2xvgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbm PROTEIN-TYROSINE-PHO
SPHATASE

(Shewanella sp.) 		PF00149
(Metallophos) 		5 GLY A 208
GLY A 209
VAL A 300
SER A 262
LEU A 295
 None
 1.00A 1ya4B-2zbmA:
undetectable		 1ya4B-2zbmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 GLY A 369
GLY A 368
VAL A 279
LEU A 377
LEU A 283
 None
 1.28A 1ya4B-3abbA:
undetectable		 1ya4B-3abbA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		5 GLY A   6
GLY A   5
VAL A 228
SER A 347
LEU A 321
 None
 1.17A 1ya4B-3alfA:
undetectable		 1ya4B-3alfA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnh UNCHARACTERIZED
PROTEIN ATU2129

(Agrobacterium
fabrum) 		PF13883
(Pyrid_oxidase_2) 		5 GLY A 109
VAL A  89
LEU A 147
MET A  81
LEU A  42
 None
 1.07A 1ya4B-3dnhA:
undetectable		 1ya4B-3dnhA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		5 GLY A 164
LEU A 125
LEU A 323
LEU A 133
LEU A 316
 None
 0.76A 1ya4B-3e3pA:
undetectable		 1ya4B-3e3pA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1b TETR-LIKE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		5 GLY A 161
LEU A 184
LEU A 187
LEU A 131
LEU A 139
 None
 1.30A 1ya4B-3f1bA:
undetectable		 1ya4B-3f1bA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Methanocaldococcus
jannaschii) 		PF00004
(AAA) 		5 GLY A 173
VAL A 338
LEU A 219
LEU A 220
LEU A 380
 ADP  A 439 (-4.0A)
None
ADP  A 439 (-4.0A)
None
None
 1.35A 1ya4B-3h4mA:
undetectable		 1ya4B-3h4mA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iq0 PUTATIVE RIBOKINASE
II

(Escherichia
coli) 		PF00294
(PfkB) 		5 GLY A 136
VAL A 148
LEU A 182
LEU A 139
HIS A 133
 None
 1.30A 1ya4B-3iq0A:
undetectable		 1ya4B-3iq0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A  89
GLY A  90
SER A 157
LEU A 192
HIS A 281
 None
 0.69A 1ya4B-3k6kA:
16.6		 1ya4B-3k6kA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A  89
GLY A  90
SER A 157
LEU A 206
HIS A 281
 None
 0.54A 1ya4B-3k6kA:
16.6		 1ya4B-3k6kA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		9 PHE A1101
GLY A1142
GLY A1143
SER A1221
VAL A1254
LEU A1358
MET A1364
LEU A1388
HIS A1468
 None
WW2  A 193 (-3.4A)
WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
None
None
None
None
None
 0.45A 1ya4B-3k9bA:
61.7		 1ya4B-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 GLY A   6
VAL A  35
LEU A   3
LEU A  39
LEU A 422
 None
 1.25A 1ya4B-3lscA:
2.3		 1ya4B-3lscA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2s NADPH-DEPENDENT
NITRO/FLAVIN
REDUCTASE

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		5 GLY A 136
VAL A 145
LEU A 142
LEU A 161
LEU A 149
 FMN  A 400 ( 3.6A)
None
None
None
None
 1.23A 1ya4B-3n2sA:
undetectable		 1ya4B-3n2sA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		5 GLY A 217
LEU A 250
LEU A 228
LEU A 191
LEU A 184
 None
 1.30A 1ya4B-3o75A:
2.9		 1ya4B-3o75A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oh8 NUCLEOSIDE-DIPHOSPHA
TE SUGAR EPIMERASE
(SULA FAMILY)

(Corynebacterium
glutamicum) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		5 GLY A 312
GLY A 313
VAL A 306
LEU A 317
LEU A 440
 None
 1.15A 1ya4B-3oh8A:
undetectable		 1ya4B-3oh8A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		5 PHE A 145
GLY A  14
LEU A  60
LEU A  59
LEU A 158
 None
 1.30A 1ya4B-3pl2A:
2.8		 1ya4B-3pl2A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN

(Salmonella
enterica) 		PF00291
(PALP) 		5 GLY B 233
GLY B 232
SER B 235
LEU B 304
LEU B 188
 7MN  B   2 (-3.7A)
7MN  B   2 ( 3.2A)
7MN  B   2 (-2.7A)
None
None
 1.10A 1ya4B-3pr2B:
undetectable		 1ya4B-3pr2B:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe7 URACIL PERMEASE

(Escherichia
coli) 		PF00860
(Xan_ur_permease) 		5 GLY A 308
GLY A 307
SER A  21
LEU A  58
LEU A  14
 None
 1.03A 1ya4B-3qe7A:
undetectable		 1ya4B-3qe7A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1

(Homo sapiens) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		5 VAL A 206
LEU A 181
LEU A 210
LEU A 108
LEU A 144
 None
 1.34A 1ya4B-3swlA:
undetectable		 1ya4B-3swlA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkn NUCLEOPORIN NUP82

(Saccharomyces
cerevisiae) 		no annotation 5 GLY A 202
GLY A 203
VAL A 317
LEU A 197
LEU A 327
 None
 1.11A 1ya4B-3tknA:
undetectable		 1ya4B-3tknA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		5 PHE A 741
GLY A 671
GLY A 672
LEU A 676
LEU A 666
 None
 1.33A 1ya4B-3ut2A:
undetectable		 1ya4B-3ut2A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vis ESTERASE

(Thermobifida
alba) 		PF12740
(Chlorophyllase2) 		5 GLY A 173
GLY A 174
VAL A 165
LEU A 139
LEU A 185
 None
 1.17A 1ya4B-3visA:
14.0		 1ya4B-3visA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		5 GLY A 124
GLY A 125
SER A 203
LEU A 126
HIS A 457
 None
 0.79A 1ya4B-3wmtA:
6.5		 1ya4B-3wmtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		5 GLY A 226
GLY A 227
LEU A 223
MET A 270
LEU A 231
 None
 1.22A 1ya4B-4ag4A:
undetectable		 1ya4B-4ag4A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		5 GLY A1360
SER A1282
VAL A1295
LEU A1289
LEU A1341
 None
 1.24A 1ya4B-4amcA:
2.1		 1ya4B-4amcA:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 134
GLY A 135
SER A 220
LEU A 355
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
PEG  A1555 (-4.6A)
None
 0.66A 1ya4B-4be9A:
37.0		 1ya4B-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 134
GLY A 135
SER A 220
SER A 309
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 1.01A 1ya4B-4be9A:
37.0		 1ya4B-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 135
SER A 220
SER A 311
LEU A 355
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
PEG  A1555 (-4.6A)
None
 0.81A 1ya4B-4be9A:
37.0		 1ya4B-4be9A:
32.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb0 LCC

(uncultured
bacterium) 		PF12695
(Abhydrolase_5) 		5 GLY A 169
GLY A 170
VAL A 161
LEU A 135
LEU A 181
 None
 1.16A 1ya4B-4eb0A:
13.9		 1ya4B-4eb0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 PHE A   9
GLY A 463
GLY A 464
LEU A 408
LEU A 211
 None
 1.14A 1ya4B-4g1pA:
2.7		 1ya4B-4g1pA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Ustilago maydis) 		PF08661
(Rep_fac-A_3) 		5 PHE A  74
GLY A  25
VAL A  96
LEU A  93
LEU A  13
 None
 1.21A 1ya4B-4gnxA:
undetectable		 1ya4B-4gnxA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i34 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Escherichia
coli) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 GLY A 249
GLY A 248
LEU A 116
LEU A 287
LEU A  88
 None
 1.09A 1ya4B-4i34A:
2.3		 1ya4B-4i34A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH) 		5 GLY C  94
GLY C  93
VAL C 241
SER C 129
LEU C 284
 None
 1.14A 1ya4B-4ifdC:
undetectable		 1ya4B-4ifdC:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		5 GLY A  66
SER A 308
LEU A 161
SER A 160
LEU A 177
 None
 0.96A 1ya4B-4jccA:
undetectable		 1ya4B-4jccA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2j AMINOTRANSFERASE

(Streptomyces
lavendulae) 		PF00155
(Aminotran_1_2) 		5 GLY A 374
LEU A 337
LEU A 301
LEU A 359
HIS A 298
 None
 1.16A 1ya4B-4m2jA:
undetectable		 1ya4B-4m2jA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhl INTERLEUKIN-11

(Homo sapiens) 		PF07400
(IL11) 		5 GLY A 169
GLY A 170
LEU A 119
LEU A 178
HIS A  70
 None
None
None
None
ARF  A 203 (-3.6A)
 1.30A 1ya4B-4mhlA:
undetectable		 1ya4B-4mhlA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		5 SER A 180
VAL A  45
LEU A  28
LEU A 165
LEU A  42
 None
 1.34A 1ya4B-4muoA:
2.5		 1ya4B-4muoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou4 ALPHA/BETA HYDROLASE
FOLD-3 DOMAIN
PROTEIN

(Pseudomonas sp.
ECU1011) 		PF07859
(Abhydrolase_3) 		5 PHE A  83
GLY A  86
GLY A  87
LEU A  36
LEU A 100
 None
 1.34A 1ya4B-4ou4A:
16.8		 1ya4B-4ou4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B

(Drosophila
melanogaster) 		PF00079
(Serpin) 		5 PHE A  77
VAL A  20
LEU A 281
LEU A  65
LEU A 288
 None
 1.32A 1ya4B-4p0fA:
undetectable		 1ya4B-4p0fA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 VAL A 658
LEU A 722
LEU A 718
LEU A 603
LEU A 653
 None
 0.89A 1ya4B-4p6wA:
undetectable		 1ya4B-4p6wA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q80 SERINE PROTEASE 57

(Homo sapiens) 		PF00089
(Trypsin) 		5 PHE A  59
GLY A 196
VAL A 231
LEU A 106
LEU A 123
 None
 1.24A 1ya4B-4q80A:
undetectable		 1ya4B-4q80A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qan HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		no annotation 5 GLY A 188
VAL A 178
LEU A 135
SER A 136
LEU A 145
 None
 1.25A 1ya4B-4qanA:
undetectable		 1ya4B-4qanA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgr DEGT/DNRJ/ERYC1/STRS
AMINOTRANSFERASE

(Brucella
abortus) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A 333
GLY A 334
SER A 340
LEU A 335
LEU A 321
 None
 1.19A 1ya4B-4qgrA:
undetectable		 1ya4B-4qgrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		5 PHE A 296
GLY A 336
LEU A 332
LEU A  22
MET A 328
 None
 1.31A 1ya4B-4ufcA:
undetectable		 1ya4B-4ufcA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
BETA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		5 GLY B  82
GLY B  81
VAL B 271
SER B  74
LEU B  93
 None
 1.25A 1ya4B-4wvmB:
undetectable		 1ya4B-4wvmB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpf ANTIBODY FRAGMENT
LIGHT CHAIN-PROTEIN,
9D5-LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H   8
GLY H   9
LEU H  18
SER H  17
LEU H 115
 None
 1.32A 1ya4B-4xpfH:
undetectable		 1ya4B-4xpfH:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dj4 SESTRIN-2

(Homo sapiens) 		PF04636
(PA26) 		5 GLY A 360
GLY A 359
LEU A  96
LEU A  99
LEU A 200
 None
 1.26A 1ya4B-5dj4A:
undetectable		 1ya4B-5dj4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO

(Homo sapiens) 		PF12933
(FTO_NTD)
PF12934
(FTO_CTD) 		5 GLY A 498
VAL A 421
LEU A 439
LEU A 435
LEU A 418
 None
 1.03A 1ya4B-5f8pA:
undetectable		 1ya4B-5f8pA:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		6 PHE A  84
GLY A 125
GLY A 126
SER A 204
LEU A 340
HIS A 449
 None
 0.38A 1ya4B-5fv4A:
63.3		 1ya4B-5fv4A:
78.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00466
(Ribosomal_L10) 		5 GLY i 257
GLY i 256
VAL i 250
LEU i  82
LEU i 273
 None
 1.30A 1ya4B-5gafi:
2.9		 1ya4B-5gafi:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A 108
GLY A 109
SER A 188
LEU A 239
HIS A 317
 TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
 0.52A 1ya4B-5hc4A:
3.6		 1ya4B-5hc4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdj NFRA1

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		5 GLY A 136
VAL A 145
LEU A 142
LEU A 161
LEU A 149
 FMN  A 400 (-3.6A)
None
None
None
None
 1.26A 1ya4B-5hdjA:
undetectable		 1ya4B-5hdjA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A  13
GLY A  14
VAL A 209
LEU A  90
LEU A  10
 FAD  A 702 (-3.6A)
FAD  A 702 (-3.9A)
None
None
None
 1.15A 1ya4B-5i68A:
undetectable		 1ya4B-5i68A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijj SPX DOMAIN

(Chaetomium
thermophilum) 		PF03105
(SPX) 		5 VAL A 159
SER A 107
LEU A 112
LEU A  76
LEU A 163
 None
 1.26A 1ya4B-5ijjA:
undetectable		 1ya4B-5ijjA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		5 PHE A 233
GLY A 172
GLY A 173
LEU A 146
LEU A 211
 None
 0.85A 1ya4B-5inrA:
undetectable		 1ya4B-5inrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00291
(PALP) 		5 GLY B 238
GLY B 237
SER B 240
LEU B 309
LEU B 192
 LLP  B  91 ( 3.6A)
LLP  B  91 ( 3.6A)
LLP  B  91 ( 2.6A)
None
None
 1.13A 1ya4B-5kinB:
2.4		 1ya4B-5kinB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku7 TIR-NB-LRR TYPE
RESISTANCE PROTEIN
RPV1

(Vitis
rotundifolia) 		PF01582
(TIR) 		5 SER A  80
LEU A  71
LEU A  70
LEU A 108
HIS A 110
 None
 1.28A 1ya4B-5ku7A:
undetectable		 1ya4B-5ku7A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1t PENTALENOLACTONE
SYNTHASE

(Streptomyces
arenae) 		PF00067
(p450) 		5 SER A 141
VAL A 396
LEU A 371
LEU A 243
LEU A 373
 None
 1.29A 1ya4B-5l1tA:
undetectable		 1ya4B-5l1tA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 GLY A 501
VAL A 460
LEU A 510
SER A 511
LEU A 540
 None
 1.36A 1ya4B-5n4lA:
undetectable		 1ya4B-5n4lA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n57 SUPEROXIDE DISMUTASE

(Staphylococcus
aureus) 		no annotation 5 GLY A  76
GLY A  75
VAL A  43
SER A  52
LEU A  48
 None
 1.15A 1ya4B-5n57A:
undetectable		 1ya4B-5n57A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 GLY B 873
GLY B 874
LEU B 891
SER B 892
LEU B 866
 None
 1.12A 1ya4B-5nd1B:
undetectable		 1ya4B-5nd1B:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nux CHROMATE REDUCTASE

(Thermus
scotoductus) 		no annotation 5 PHE A 223
GLY A 292
LEU A 306
LEU A  53
LEU A   4
 None
 0.97A 1ya4B-5nuxA:
undetectable		 1ya4B-5nuxA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Streptosporangium
roseum) 		no annotation 5 GLY A 276
GLY A 275
VAL A 239
LEU A 270
MET A 282
 None
 1.04A 1ya4B-5ocmA:
undetectable		 1ya4B-5ocmA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE

(Azospirillum
brasilense) 		no annotation 5 GLY A  12
VAL A 284
SER A   5
LEU A  11
LEU A 288
 None
 1.22A 1ya4B-5ovoA:
undetectable		 1ya4B-5ovoA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE

(Cupriavidus
necator) 		PF07167
(PhaC_N) 		5 GLY A 321
GLY A 322
VAL A 343
LEU A 345
LEU A 274
 None
 1.01A 1ya4B-5t6oA:
4.2		 1ya4B-5t6oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 5 PHE A 700
GLY A 630
GLY A 631
LEU A 635
LEU A 625
 None
 1.34A 1ya4B-5whsA:
undetectable		 1ya4B-5whsA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9v RYANODINE RECEPTOR 1

(Plutella
xylostella) 		no annotation 5 VAL A 187
LEU A  25
SER A  26
LEU A 176
LEU A  48
 None
 1.21A 1ya4B-5y9vA:
undetectable		 1ya4B-5y9vA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 5 GLY A 876
VAL A 792
LEU A 979
LEU A 976
LEU A 803
 None
 1.31A 1ya4B-6cnhA:
undetectable		 1ya4B-6cnhA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cyz HOMOSERINE KINASE

(Mycobacteroides
abscessus) 		no annotation 5 GLY A  80
GLY A  79
VAL A 130
LEU A 118
LEU A 131
 None
 1.27A 1ya4B-6cyzA:
undetectable		 1ya4B-6cyzA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm9 UDP-N-ACETYLGLUCOSAM
INE--DOLICHYL-PHOSPH
ATE
N-ACETYLGLUCOSAMINEP
HOSPHOTRANSFERASE

(Homo sapiens) 		no annotation 5 VAL A 370
LEU A 363
LEU A 366
LEU A 389
LEU A 371
 None
 1.29A 1ya4B-6fm9A:
undetectable		 1ya4B-6fm9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 5 GLY A  90
GLY A  91
SER A 169
LEU A  92
HIS A 421
 None
 0.81A 1ya4B-6g21A:
10.0		 1ya4B-6g21A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		4 LEU A 158
PRO A 258
ILE A 245
LEU A 236
 None
 1.14A 1ya4B-1a2oA:
3.2		 1ya4B-1a2oA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0z PROTEIN
(PHOSPHOGLUCOSE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00342
(PGI) 		4 LEU A 127
PRO A 213
ILE A 134
LEU A 132
 None
 1.04A 1ya4B-1b0zA:
0.8		 1ya4B-1b0zA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dll TETANUS TOXIN

(Clostridium
tetani) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 LEU A 889
PRO A 910
ILE A 934
LEU A1072
 None
 1.04A 1ya4B-1dllA:
undetectable		 1ya4B-1dllA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 LEU A1164
PRO A1104
ILE A1100
LEU A1098
 None
 1.10A 1ya4B-1f20A:
undetectable		 1ya4B-1f20A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 LEU A 330
PRO A 367
ILE A 374
LEU A 375
 None
 1.11A 1ya4B-1jqoA:
0.9		 1ya4B-1jqoA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0x METHIONINE
AMINOPEPTIDASE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24) 		4 LEU A 198
PRO A 208
ILE A 241
LEU A 204
 None
 1.10A 1ya4B-1o0xA:
undetectable		 1ya4B-1o0xA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 LEU 1  29
PRO 1  82
ILE 1 275
LEU 1 274
 None
 1.05A 1ya4B-1poy1:
0.8		 1ya4B-1poy1:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 LEU A 121
PRO A  89
ILE A  83
LEU A  84
 None
 1.03A 1ya4B-1q20A:
0.5		 1ya4B-1q20A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 LEU A 131
PRO A 168
ILE A 163
LEU A 164
 None
 1.09A 1ya4B-1w6jA:
0.0		 1ya4B-1w6jA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		4 LEU B 265
PRO B 280
ILE B 276
LEU B 244
 None
 1.04A 1ya4B-1zunB:
undetectable		 1ya4B-1zunB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 LEU A 261
PRO A 206
ILE A 341
LEU A 202
 None
 1.04A 1ya4B-2abjA:
undetectable		 1ya4B-2abjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d86 VAV-3 PROTEIN

(Homo sapiens) 		PF11971
(CAMSAP_CH) 		4 LEU A  18
PRO A 137
ILE A 116
LEU A 119
 None
 1.05A 1ya4B-2d86A:
undetectable		 1ya4B-2d86A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		4 LEU A 400
PRO A 407
ILE A 364
LEU A  26
 None
 1.13A 1ya4B-2dkjA:
undetectable		 1ya4B-2dkjA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgs PUTATIVE PERIPLASMIC
PROTEIN

(Campylobacter
jejuni) 		PF04264
(YceI) 		4 LEU A 155
PRO A  60
ILE A  56
LEU A  68
 None
 1.01A 1ya4B-2fgsA:
undetectable		 1ya4B-2fgsA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frg TREM-LIKE
TRANSCRIPT-1

(Homo sapiens) 		no annotation 4 LEU P  87
PRO P  23
ILE P 114
LEU P 115
 None
 1.11A 1ya4B-2frgP:
undetectable		 1ya4B-2frgP:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2him L-ASPARAGINASE 1

(Escherichia
coli) 		PF00710
(Asparaginase) 		4 LEU A  35
PRO A  26
ILE A  15
LEU A 121
 None
 0.86A 1ya4B-2himA:
2.0		 1ya4B-2himA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqm GLUTATHIONE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 438
PRO A 380
ILE A 448
LEU A 449
 None
 1.07A 1ya4B-2hqmA:
undetectable		 1ya4B-2hqmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 277
PRO A 205
ILE A 164
LEU A 224
 None
 1.10A 1ya4B-2iwiA:
undetectable		 1ya4B-2iwiA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 651
PRO A 622
ILE A 615
LEU A 616
 None
 0.99A 1ya4B-2jkmA:
undetectable		 1ya4B-2jkmA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldy ORF1 CODES FOR A 40
KDA PRODUCT

(Homo sapiens) 		PF02994
(Transposase_22)
PF17490
(Tnp_22_dsRBD) 		4 LEU A 158
PRO A 164
ILE A 181
LEU A 178
 None
 1.05A 1ya4B-2ldyA:
undetectable		 1ya4B-2ldyA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		4 LEU A  94
PRO A  80
ILE A  75
LEU A  74
 SAH  A 301 ( 4.9A)
None
None
None
 1.10A 1ya4B-2pbfA:
undetectable		 1ya4B-2pbfA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa5 FILAMIN-B

(Homo sapiens) 		PF00307
(CH) 		4 LEU A  53
PRO A 126
ILE A 118
LEU A 117
 None
 0.87A 1ya4B-2wa5A:
undetectable		 1ya4B-2wa5A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv5 YJEQ PROTEIN

(Aquifex
aeolicus) 		PF03193
(RsgA_GTPase) 		4 LEU A 163
PRO A 224
ILE A 181
LEU A 185
 None
 0.86A 1ya4B-2yv5A:
1.2		 1ya4B-2yv5A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		4 LEU A  17
PRO A 260
ILE A 300
LEU A 297
 None
 1.06A 1ya4B-2yy5A:
undetectable		 1ya4B-2yy5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 LEU B 177
PRO B 162
ILE B 119
LEU B 106
 None
 1.06A 1ya4B-3al0B:
undetectable		 1ya4B-3al0B:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjq PHAGE-RELATED
PROTEIN

(Bordetella
bronchiseptica) 		PF03864
(Phage_cap_E) 		4 LEU A 131
PRO A 176
ILE A 307
LEU A 306
 None
 0.89A 1ya4B-3bjqA:
undetectable		 1ya4B-3bjqA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnh UNCHARACTERIZED
PROTEIN ATU2129

(Agrobacterium
fabrum) 		PF13883
(Pyrid_oxidase_2) 		4 LEU A 233
PRO A  63
ILE A 214
LEU A 224
 None
 1.04A 1ya4B-3dnhA:
undetectable		 1ya4B-3dnhA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		4 LEU A 393
PRO A  43
ILE A 128
LEU A 131
 None
 0.79A 1ya4B-3ed4A:
undetectable		 1ya4B-3ed4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 654
PRO A 625
ILE A 618
LEU A 619
 None
 0.99A 1ya4B-3fzpA:
undetectable		 1ya4B-3fzpA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		4 LEU A 160
PRO A 168
ILE A 173
LEU A 177
 None
 0.98A 1ya4B-3h9pA:
undetectable		 1ya4B-3h9pA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcj PEPTIDE METHIONINE
SULFOXIDE REDUCTASE

(Xanthomonas
campestris) 		PF01641
(SelR) 		4 LEU A 131
PRO A  37
ILE A 100
LEU A 109
 None
 1.02A 1ya4B-3hcjA:
undetectable		 1ya4B-3hcjA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoc FILAMIN-A

(Homo sapiens) 		PF00307
(CH) 		4 LEU A  80
PRO A 153
ILE A 145
LEU A 144
 None
 0.85A 1ya4B-3hocA:
undetectable		 1ya4B-3hocA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilw DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis) 		PF00521
(DNA_topoisoIV) 		4 LEU A 205
PRO A 167
ILE A 373
LEU A 370
 None
 0.85A 1ya4B-3ilwA:
undetectable		 1ya4B-3ilwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I

(Yersinia pestis) 		PF00710
(Asparaginase) 		4 LEU A  35
PRO A  26
ILE A  15
LEU A 121
 None
 0.90A 1ya4B-3ntxA:
undetectable		 1ya4B-3ntxA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oi8 UNCHARACTERIZED
PROTEIN

(Neisseria
meningitidis) 		PF00571
(CBS) 		4 LEU A  73
PRO A 120
ILE A 128
LEU A 125
 GOL  A   1 (-4.1A)
None
None
None
 1.00A 1ya4B-3oi8A:
undetectable		 1ya4B-3oi8A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qum PROSTATE-SPECIFIC
ANTIGEN

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU P  53
PRO P 111
ILE P 242
LEU P 105
 None
 1.11A 1ya4B-3qumP:
undetectable		 1ya4B-3qumP:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnx PAPAIN

(Carica papaya) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 LEU A 309
PRO A 316
ILE A 232
LEU A 228
 None
 1.09A 1ya4B-3tnxA:
undetectable		 1ya4B-3tnxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 LEU A 361
PRO A 410
ILE A 420
LEU A 417
 None
 1.08A 1ya4B-4aioA:
undetectable		 1ya4B-4aioA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 4 LEU A 416
PRO A 411
ILE A 463
LEU A 404
 None
IOD  A1721 ( 4.8A)
None
None
 0.99A 1ya4B-4aw7A:
undetectable		 1ya4B-4aw7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7l FILAMIN-B

(Homo sapiens) 		PF00307
(CH)
PF00630
(Filamin) 		4 LEU A  53
PRO A 126
ILE A 118
LEU A 117
 None
 0.91A 1ya4B-4b7lA:
undetectable		 1ya4B-4b7lA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01369
(Sec7)
PF16453
(IQ_SEC7_PH) 		4 LEU A 663
PRO A 641
ILE A 703
LEU A 705
 None
 1.11A 1ya4B-4c0aA:
undetectable		 1ya4B-4c0aA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		4 LEU A 292
PRO A  91
ILE A 304
LEU A 303
 None
 1.12A 1ya4B-4c1nA:
undetectable		 1ya4B-4c1nA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 5

(Saccharomyces
cerevisiae) 		PF10483
(Elong_Iki1) 		4 LEU B  38
PRO B   8
ILE B  15
LEU B  16
 None
 1.07A 1ya4B-4ejsB:
undetectable		 1ya4B-4ejsB:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ely DNA GYRASE SUBUNIT A

(Shigella
flexneri) 		PF00521
(DNA_topoisoIV) 		4 LEU A 474
PRO A 392
ILE A 458
LEU A 461
 None
 1.02A 1ya4B-4elyA:
undetectable		 1ya4B-4elyA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		4 LEU A  52
PRO A 213
ILE A  28
LEU A  56
 None
 1.10A 1ya4B-4f3eA:
undetectable		 1ya4B-4f3eA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		4 LEU A 191
PRO A  75
ILE A 107
LEU A  94
 None
 1.02A 1ya4B-4fajA:
undetectable		 1ya4B-4fajA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		4 LEU A1123
PRO A 739
ILE A 762
LEU A 765
 None
 1.13A 1ya4B-4fwtA:
undetectable		 1ya4B-4fwtA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE

(Trichormus
variabilis) 		PF00171
(Aldedh) 		4 LEU A 179
PRO A 100
ILE A 145
LEU A 148
 None
 1.07A 1ya4B-4h7nA:
undetectable		 1ya4B-4h7nA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Flavobacterium
johnsoniae) 		PF01884
(PcrB) 		4 LEU A 103
PRO A  87
ILE A 112
LEU A 111
 None
PGE  A 302 ( 3.2A)
None
None
 1.02A 1ya4B-4jejA:
undetectable		 1ya4B-4jejA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwo PHOSPHATE BINDING
PROTEIN

(Planctopirus
limnophila) 		PF12727
(PBP_like) 		4 LEU A 160
PRO A 181
ILE A 145
LEU A 235
 None
 0.81A 1ya4B-4jwoA:
undetectable		 1ya4B-4jwoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 LEU A 588
PRO A 409
ILE A 554
LEU A 551
 None
 1.03A 1ya4B-4kf7A:
undetectable		 1ya4B-4kf7A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 4 LEU H 245
PRO H 181
ILE H  59
LEU H  62
 None
 1.09A 1ya4B-4l0oH:
undetectable		 1ya4B-4l0oH:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lna PURINE NUCLEOSIDE
PHOSPHORYLASE

(Spirosoma
linguale) 		PF01048
(PNP_UDP_1) 		4 LEU A 163
PRO A  20
ILE A 268
LEU A 271
 None
 1.13A 1ya4B-4lnaA:
undetectable		 1ya4B-4lnaA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		4 LEU A 541
PRO A 249
ILE A 556
LEU A 559
 None
 1.04A 1ya4B-4mzdA:
1.8		 1ya4B-4mzdA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nb5 DNA BINDING PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A  41
PRO A  99
ILE A  77
LEU A  76
 None
 1.01A 1ya4B-4nb5A:
undetectable		 1ya4B-4nb5A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR

(Bifidobacterium
animalis) 		PF13377
(Peripla_BP_3) 		4 LEU A  96
PRO A 166
ILE A 316
LEU A 313
 None
 0.99A 1ya4B-4o5aA:
2.1		 1ya4B-4o5aA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 722
PRO A 753
ILE A 740
LEU A 757
 None
 1.14A 1ya4B-4oliA:
undetectable		 1ya4B-4oliA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9f HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MCBR

(Escherichia
coli) 		PF00392
(GntR)
PF07729
(FCD) 		4 LEU A 215
PRO A  75
ILE A  85
LEU A  82
 None
 0.83A 1ya4B-4p9fA:
undetectable		 1ya4B-4p9fA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG

(Homo sapiens) 		PF08514
(STAG)
no annotation 		4 LEU A 825
PRO B 376
ILE A 794
LEU A 795
 None
 0.95A 1ya4B-4pjuA:
undetectable		 1ya4B-4pjuA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ric FANCONI-ASSOCIATED
NUCLEASE 1

(Homo sapiens) 		PF08774
(VRR_NUC) 		4 LEU A 571
PRO A 541
ILE A 548
LEU A 549
 None
 1.08A 1ya4B-4ricA:
2.5		 1ya4B-4ricA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		4 LEU A 393
PRO A 348
ILE A 380
LEU A 381
 None
 0.98A 1ya4B-4s38A:
undetectable		 1ya4B-4s38A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		4 LEU A 180
PRO A 162
ILE A 105
LEU A 166
 None
 1.03A 1ya4B-4us5A:
undetectable		 1ya4B-4us5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB

(Burkholderia
cenocepacia) 		PF00155
(Aminotran_1_2) 		4 LEU A 380
PRO A 184
ILE A 369
LEU A  31
 None
 0.97A 1ya4B-4wd2A:
undetectable		 1ya4B-4wd2A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 358
PRO A 271
ILE A 258
LEU A 256
 None
 0.85A 1ya4B-4wyrA:
undetectable		 1ya4B-4wyrA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgz ANTIZYME INHIBITOR 1

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 LEU A 212
PRO A 272
ILE A 268
LEU A 232
 None
 0.88A 1ya4B-4zgzA:
undetectable		 1ya4B-4zgzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ax0 RHODOPSIN I

(Acetabularia
acetabulum) 		PF01036
(Bac_rhodopsin) 		4 LEU A  98
PRO A 189
ILE A 182
LEU A 181
 None
RET  A 301 (-4.1A)
None
None
 0.92A 1ya4B-5ax0A:
undetectable		 1ya4B-5ax0A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv3 M7GPPPX
DIPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		4 LEU A 233
PRO A 262
ILE A 294
LEU A 291
 None
M7G  A 401 (-4.6A)
None
None
 1.12A 1ya4B-5bv3A:
undetectable		 1ya4B-5bv3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 LEU A 486
PRO A 435
ILE A 505
LEU A 472
 None
 1.04A 1ya4B-5c0yA:
undetectable		 1ya4B-5c0yA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		4 LEU A 278
PRO A 418
ILE A 289
LEU A 288
 None
 1.09A 1ya4B-5c2iA:
undetectable		 1ya4B-5c2iA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A 503
PRO A 733
ILE A 512
LEU A 456
 None
 1.09A 1ya4B-5cioA:
undetectable		 1ya4B-5cioA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 LEU A 272
PRO A  91
ILE A  98
LEU A  99
 None
 1.01A 1ya4B-5d6bA:
undetectable		 1ya4B-5d6bA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e04 NUCLEOPROTEIN

(Andes
orthohantavirus) 		PF00846
(Hanta_nucleocap) 		4 LEU A 205
PRO A 325
ILE A 284
LEU A 294
 None
 1.01A 1ya4B-5e04A:
undetectable		 1ya4B-5e04A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU B 359
PRO B 272
ILE B 259
LEU B 257
 None
 0.86A 1ya4B-5f38B:
undetectable		 1ya4B-5f38B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq2 SUMO-ACTIVATING
ENZYME SUBUNIT 2

(Homo sapiens) 		PF14732
(UAE_UbL) 		4 LEU B 506
PRO B 478
ILE B 530
LEU B 517
 MLZ  B 505 ( 4.2A)
None
None
None
 1.12A 1ya4B-5fq2B:
undetectable		 1ya4B-5fq2B:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvi UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Danio rerio) 		PF00443
(UCH) 		4 LEU A 310
PRO A 252
ILE A 319
LEU A 247
 None
 1.11A 1ya4B-5gviA:
undetectable		 1ya4B-5gviA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0r VP4 PROTEIN

(Cypovirus 1) 		no annotation 4 LEU G 175
PRO G   6
ILE G  52
LEU G  56
 None
 1.12A 1ya4B-5h0rG:
undetectable		 1ya4B-5h0rG:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu7 PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		4 LEU A3082
PRO A3092
ILE A2891
LEU A2894
 None
 1.14A 1ya4B-5hu7A:
undetectable		 1ya4B-5hu7A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idb NATTERIN-3

(Crassostrea
gigas) 		no annotation 4 LEU B  48
PRO B  41
ILE B 111
LEU B  28
 BMA  B1001 ( 4.9A)
None
None
None
 1.13A 1ya4B-5idbB:
undetectable		 1ya4B-5idbB:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jge APE1 PROPEPTIDE
AUTOPHAGY-RELATED
PROTEIN 19

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 170
PRO C   0
ILE C   7
LEU C   8
 None
 1.09A 1ya4B-5jgeA:
undetectable		 1ya4B-5jgeA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 LEU A 350
PRO A 355
ILE A 280
LEU A 217
 None
 1.04A 1ya4B-5jouA:
undetectable		 1ya4B-5jouA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF14533
(USP7_C2) 		4 LEU A 232
PRO A 399
ILE A 320
LEU A 238
 None
 1.12A 1ya4B-5jtvA:
undetectable		 1ya4B-5jtvA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kl0 PHOSPHOGLUCOMUTASE

(Xanthomonas
citri) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A 444
PRO A 301
ILE A 424
LEU A 435
 None
 1.10A 1ya4B-5kl0A:
1.2		 1ya4B-5kl0A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 LEU A 139
PRO A  91
ILE A  98
LEU A  99
 None
 1.06A 1ya4B-5l9wA:
undetectable		 1ya4B-5l9wA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq4 CYAGOX

(Cyanothece sp.
PCC 7425) 		PF00881
(Nitroreductase) 		4 LEU A 191
PRO A  92
ILE A 145
LEU A 143
 None
 0.99A 1ya4B-5lq4A:
undetectable		 1ya4B-5lq4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3c DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A1080
PRO A1100
ILE A1086
LEU A1085
 None
 1.13A 1ya4B-5m3cA:
undetectable		 1ya4B-5m3cA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 LEU A 889
PRO A 910
ILE A 934
LEU A1072
 None
 1.09A 1ya4B-5n0cA:
undetectable		 1ya4B-5n0cA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nno ALDEHYDE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00171
(Aldedh) 		4 LEU A  49
PRO A   9
ILE A 134
LEU A 131
 None
 1.09A 1ya4B-5nnoA:
0.6		 1ya4B-5nnoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0x PUTATIVE FERRIC
REDUCTASE

(Cylindrospermum
stagnale) 		PF08022
(FAD_binding_8)
PF08030
(NAD_binding_6) 		4 LEU A 533
PRO A 467
ILE A 550
LEU A 547
 None
 0.93A 1ya4B-5o0xA:
undetectable		 1ya4B-5o0xA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzk GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		PF00535
(Glycos_transf_2) 		4 LEU C 162
PRO C  71
ILE C   6
LEU C  79
 None
UDP  C 401 (-3.5A)
None
None
 1.13A 1ya4B-5tzkC:
undetectable		 1ya4B-5tzkC:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uib OXIDOREDUCTASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 191
PRO A 132
ILE A 255
LEU A 140
 None
 0.98A 1ya4B-5uibA:
2.2		 1ya4B-5uibA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		4 LEU A 130
PRO A  27
ILE A  95
LEU A  98
 None
 1.08A 1ya4B-5ujsA:
undetectable		 1ya4B-5ujsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1d PROTOCADHERIN-15

(Mus musculus) 		no annotation 4 LEU A 735
PRO A 701
ILE A 786
LEU A 766
 None
 1.12A 1ya4B-5w1dA:
undetectable		 1ya4B-5w1dA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w75 ELONGATION FACTOR TU

(Thermotoga
neapolitana) 		no annotation 4 LEU A 157
PRO A 129
ILE A  18
LEU A 104
 None
 1.08A 1ya4B-5w75A:
undetectable		 1ya4B-5w75A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a0z HEMAGGLUTININ,ENVELO
PE GLYCOPROTEIN

(Human
immunodeficiency
virus 1;
Influenza A
virus) 		no annotation 4 LEU A  70
PRO A  58
ILE A 267
LEU A 112
 None
 1.13A 1ya4B-6a0zA:
undetectable		 1ya4B-6a0zA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao1 BETA-LACTAMASE
DOMAIN PROTEIN

(Paraburkholderia
phymatum) 		PF00753
(Lactamase_B) 		4 LEU A 212
PRO A 207
ILE A 121
LEU A 184
 None
 1.08A 1ya4B-6ao1A:
undetectable		 1ya4B-6ao1A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Mus musculus) 		no annotation 4 LEU B 510
PRO B 501
ILE B 474
LEU B 477
 None
 1.08A 1ya4B-6bcqB:
1.3		 1ya4B-6bcqB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD

(Bacillus
thuringiensis) 		no annotation 4 LEU A  60
PRO A  30
ILE A  10
LEU A   9
 None
 1.14A 1ya4B-6bwcA:
1.2		 1ya4B-6bwcA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 117
PRO A 477
ILE A  37
LEU A  33
 EGY  A 801 (-4.8A)
None
None
None
 1.10A 1ya4B-6c26A:
undetectable		 1ya4B-6c26A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
putida) 		no annotation 4 LEU A 131
PRO A  27
ILE A  96
LEU A  99
 None
 1.14A 1ya4B-6cn1A:
0.7		 1ya4B-6cn1A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN

(Homo sapiens) 		no annotation 4 LEU A 508
PRO A 482
ILE A 550
LEU A 486
 None
 1.02A 1ya4B-6ei1A:
undetectable		 1ya4B-6ei1A:
8.45