SIMILAR PATTERNS OF AMINO ACIDS FOR 1YA4_B_CTXB1283_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 170
GLY A 168
LEU A 191
PRO A 176
 None
 0.85A 1ya4B-1ebdA:
1.9		 1ya4B-1ebdA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		4 LEU A  69
GLY A 105
LEU A  79
PRO A  37
 None
 0.79A 1ya4B-1j1uA:
1.7		 1ya4B-1j1uA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 174
GLY A 172
LEU A 195
PRO A 180
 None
 0.93A 1ya4B-1lpfA:
undetectable		 1ya4B-1lpfA:
24.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 PRO E 137
LEU E 163
GLY E 161
LEU E 131
 None
 0.79A 1ya4B-1nfiE:
undetectable		 1ya4B-1nfiE:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 LEU A1217
GLY A 736
LEU A 484
PRO A1079
 None
 0.88A 1ya4B-1ofeA:
undetectable		 1ya4B-1ofeA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puc P13SUC1

(Schizosaccharomyces
pombe) 		PF01111
(CKS) 		4 PRO A  52
LEU A  74
GLY A  75
LEU A  10
 None
 0.91A 1ya4B-1pucA:
undetectable		 1ya4B-1pucA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb3 CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01111
(CKS) 		4 PRO A  55
LEU A  77
GLY A  78
LEU A  13
 None
 0.89A 1ya4B-1qb3A:
undetectable		 1ya4B-1qb3A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 PRO A 169
LEU A  75
GLY A  74
LYS A 244
 None
NAP  A3075 ( 4.2A)
NAP  A3075 ( 4.7A)
None
 0.93A 1ya4B-1suwA:
2.3		 1ya4B-1suwA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli) 		PF02541
(Ppx-GppA) 		4 LEU A 441
GLY A 442
LEU A 486
PRO A 455
 None
 0.77A 1ya4B-1u6zA:
undetectable		 1ya4B-1u6zA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuo DIHYDROOROTATE
DEHYDROGENASE

(Rattus rattus) 		PF01180
(DHO_dh) 		4 LEU A 343
GLY A 339
LEU A 378
PRO A  91
 None
 0.84A 1ya4B-1uuoA:
undetectable		 1ya4B-1uuoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		4 PRO A 269
LEU A 280
GLY A 247
PRO A 196
 None
 0.90A 1ya4B-1vf8A:
undetectable		 1ya4B-1vf8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 PRO A 234
LEU A 244
GLY A 245
LEU A 213
 None
 0.90A 1ya4B-1vftA:
undetectable		 1ya4B-1vftA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)

(Mus musculus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 PRO B 380
LEU B 437
GLY B 438
LEU B 512
 None
 0.86A 1ya4B-1vkxB:
undetectable		 1ya4B-1vkxB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxv BAG-FAMILY MOLECULAR
CHAPERONE
REGULATOR-1

(Homo sapiens) 		PF00240
(ubiquitin) 		4 PRO A  32
LEU A  68
GLY A  72
LEU A   8
 None
 0.83A 1ya4B-1wxvA:
undetectable		 1ya4B-1wxvA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 LEU A 180
GLY A 181
LEU A 189
PRO A 238
 None
 0.88A 1ya4B-1xeuA:
undetectable		 1ya4B-1xeuA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzw GFP-LIKE
NON-FLUORESCENT
CHROMOPROTEIN

(Heteractis
crispa) 		PF01353
(GFP) 		4 LEU A   5
GLY A   4
LEU A 111
PRO A  35
 None
 0.81A 1ya4B-1yzwA:
undetectable		 1ya4B-1yzwA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 PRO A 169
LEU A  75
GLY A  74
LYS A 244
 None
NAP  A3076 (-4.3A)
NAP  A3076 ( 4.9A)
None
 0.91A 1ya4B-1z0uA:
2.3		 1ya4B-1z0uA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6u NP95-LIKE RING
FINGER PROTEIN
ISOFORM B

(Homo sapiens) 		PF00097
(zf-C3HC4) 		4 PRO A 769
LEU A 775
GLY A 776
LEU A 757
 None
 0.86A 1ya4B-1z6uA:
undetectable		 1ya4B-1z6uA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buf ACETYLGLUTAMATE
KINASE

(Pseudomonas
aeruginosa) 		PF00696
(AA_kinase) 		4 PRO A 180
LEU A 126
GLY A 128
LEU A 170
 None
 0.78A 1ya4B-2bufA:
undetectable		 1ya4B-2bufA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwq REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2

(Rattus
norvegicus) 		PF00168
(C2) 		4 PRO A 765
LEU A 831
GLY A 832
LEU A 754
 None
 0.90A 1ya4B-2bwqA:
undetectable		 1ya4B-2bwqA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbn HYPOTHETICAL PROTEIN
YBIU

(Escherichia
coli) 		PF07350
(DUF1479) 		4 TRP A  61
LEU A  53
GLY A  57
PRO A 329
 None
 0.92A 1ya4B-2dbnA:
undetectable		 1ya4B-2dbnA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6e 5'-NUCLEOTIDASE SURE

(Thermus
thermophilus) 		PF01975
(SurE) 		4 LEU A 119
GLY A 117
LEU A 229
PRO A 158
 None
 0.86A 1ya4B-2e6eA:
1.3		 1ya4B-2e6eA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep6 MCTP2 PROTEIN

(Homo sapiens) 		PF00168
(C2) 		4 PRO A 120
LEU A 175
GLY A 176
LEU A 109
 None
 0.88A 1ya4B-2ep6A:
undetectable		 1ya4B-2ep6A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		4 PRO A 235
LEU A 229
GLY A 228
LEU A 218
 None
 0.93A 1ya4B-2go4A:
undetectable		 1ya4B-2go4A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Chlorobaculum
tepidum) 		PF13419
(HAD_2) 		4 PRO A 130
LEU A 127
GLY A 123
LEU A  15
 None
 0.93A 1ya4B-2hcfA:
2.6		 1ya4B-2hcfA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		4 PRO A 188
LEU A 151
GLY A 153
LEU A 178
 None
 0.66A 1ya4B-2hmfA:
undetectable		 1ya4B-2hmfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m2t REPAIR DNA
POLYMERASE X

(African swine
fever virus) 		PF14791
(DNA_pol_B_thumb) 		4 LEU A 137
GLY A 141
LEU A 163
PRO A 110
 None
 0.90A 1ya4B-2m2tA:
undetectable		 1ya4B-2m2tA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		4 TRP A  81
GLY A  67
LEU A  74
PRO A 404
 None
 0.88A 1ya4B-2pyjA:
undetectable		 1ya4B-2pyjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A

(Methanosarcina
mazei) 		PF04406
(TP6A_N) 		4 PRO A 257
GLY A 338
LEU A 313
PRO A 292
 None
 0.88A 1ya4B-2q2eA:
2.8		 1ya4B-2q2eA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		4 PRO A 177
LEU A 134
GLY A 136
LEU A 167
 None
 0.61A 1ya4B-2rd5A:
undetectable		 1ya4B-2rd5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PRO A  87
GLY A 239
LEU A 256
PRO A 247
 None
 0.81A 1ya4B-2v7bA:
undetectable		 1ya4B-2v7bA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY

(Desulfomicrobium
norvegicum) 		PF04358
(DsrC) 		4 PRO C  64
GLY C  87
LEU C  53
PRO C 101
 None
 0.93A 1ya4B-2xsjC:
undetectable		 1ya4B-2xsjC:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvx CHELATASE, PUTATIVE

(Desulfovibrio
vulgaris) 		PF06180
(CbiK) 		4 PRO A 148
LEU A 179
GLY A 181
LEU A 196
 None
 0.83A 1ya4B-2xvxA:
undetectable		 1ya4B-2xvxA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0h PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 PRO A 113
LEU A 180
GLY A 198
LEU A 150
 None
 0.79A 1ya4B-2y0hA:
undetectable		 1ya4B-2y0hA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8v CLASS III CHITINASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		4 LEU A  90
GLY A  88
LEU A 115
PRO A  64
 None
 0.93A 1ya4B-2y8vA:
undetectable		 1ya4B-2y8vA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3p METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF01596
(Methyltransf_3) 		4 LEU A 142
GLY A 138
LEU A 155
PRO A  62
 None
 0.76A 1ya4B-3c3pA:
undetectable		 1ya4B-3c3pA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 PRO A 692
LEU A 621
GLY A 617
LEU A 695
 None
 0.82A 1ya4B-3cf4A:
undetectable		 1ya4B-3cf4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8p ACETYLTRANSFERASE OF
GNAT FAMILY

(Staphylococcus
aureus) 		PF13673
(Acetyltransf_10) 		4 TRP A  55
LEU A  99
GLY A  95
LEU A  80
 None
None
EDO  A 168 ( 4.4A)
EDO  A 167 (-4.4A)
 0.68A 1ya4B-3d8pA:
undetectable		 1ya4B-3d8pA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzb PREPHENATE
DEHYDROGENASE

(Streptococcus
thermophilus) 		PF02153
(PDH) 		4 PRO A 124
LEU A 166
GLY A 168
LEU A  18
 None
 0.90A 1ya4B-3dzbA:
undetectable		 1ya4B-3dzbA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6q PUTATIVE
5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF02962
(CHMI) 		4 PRO A   2
LEU A  80
GLY A  81
LEU A  29
 None
 0.84A 1ya4B-3e6qA:
undetectable		 1ya4B-3e6qA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epd PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 PRO 2  56
LEU 2  91
GLY 2  90
PRO 2 254
 None
 0.93A 1ya4B-3epd2:
undetectable		 1ya4B-3epd2:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fl2 E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		no annotation 4 PRO A 760
LEU A 766
GLY A 767
LEU A 748
 None
 0.87A 1ya4B-3fl2A:
undetectable		 1ya4B-3fl2A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8q PREDICTED
RNA-BINDING PROTEIN,
CONTAINS THUMP
DOMAIN

(Methanopyrus
kandleri) 		PF00383
(dCMP_cyt_deam_1)
PF02926
(THUMP) 		4 PRO A 156
LEU A 112
GLY A  88
LEU A  91
 None
 0.81A 1ya4B-3g8qA:
undetectable		 1ya4B-3g8qA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcj PEPTIDE METHIONINE
SULFOXIDE REDUCTASE

(Xanthomonas
campestris) 		PF01641
(SelR) 		4 LEU A 109
GLY A 110
LEU A 131
PRO A  74
 None
 0.82A 1ya4B-3hcjA:
undetectable		 1ya4B-3hcjA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Geobacter
metallireducens) 		PF00155
(Aminotran_1_2) 		4 PRO A 112
LEU A 133
GLY A 135
LEU A 160
 None
 0.76A 1ya4B-3hdoA:
undetectable		 1ya4B-3hdoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiw VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		4 PRO A 199
LEU A 139
GLY A 140
LEU A 184
 None
 0.91A 1ya4B-3hiwA:
undetectable		 1ya4B-3hiwA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 LEU A 187
GLY A 191
LEU A 203
PRO A 254
 None
 0.65A 1ya4B-3hvdA:
undetectable		 1ya4B-3hvdA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		4 PRO A 575
LEU A 567
GLY A 568
LEU A 656
 None
 0.93A 1ya4B-3i04A:
undetectable		 1ya4B-3i04A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		4 LEU A 515
GLY A 511
LEU A 550
PRO A 220
 None
 0.87A 1ya4B-3i6rA:
undetectable		 1ya4B-3i6rA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP2

(Enterovirus B) 		PF00073
(Rhv) 		4 PRO C  47
LEU C  82
GLY C  81
PRO C 238
 None
 0.92A 1ya4B-3j2jC:
undetectable		 1ya4B-3j2jC:
18.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		5 TRP A1357
PRO A1360
LEU A1368
LEU A1418
PRO A1461
 None
 0.53A 1ya4B-3k9bA:
61.7		 1ya4B-3k9bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		5 TRP A1357
PRO A1360
LYS A1414
LEU A1418
PRO A1461
 None
 1.37A 1ya4B-3k9bA:
61.7		 1ya4B-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		4 PRO A 495
LEU A 534
GLY A 536
LEU A 487
 None
 0.92A 1ya4B-3kt4A:
undetectable		 1ya4B-3kt4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		4 PRO A 424
LEU A 428
GLY A 431
LEU A 414
 None
 0.80A 1ya4B-3kv6A:
undetectable		 1ya4B-3kv6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcp GLUCOKINASE

(Parabacteroides
distasonis) 		PF00480
(ROK) 		4 LEU A 154
GLY A 155
LEU A 242
PRO A 217
 None
None
None
GOL  A 366 ( 4.5A)
 0.93A 1ya4B-3mcpA:
undetectable		 1ya4B-3mcpA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg3 ORANGE
CAROTENOID-BINDING
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF02136
(NTF2)
PF09150
(Carot_N) 		4 LEU A 116
GLY A 114
LEU A  68
PRO A  56
 None
ECH  A 351 (-2.8A)
None
GOL  A 324 (-4.1A)
 0.80A 1ya4B-3mg3A:
undetectable		 1ya4B-3mg3A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbe RICIN B-LIKE LECTIN

(Clitocybe
nebularis) 		PF14200
(RicinB_lectin_2) 		4 LEU A 128
GLY A  81
LEU A  84
PRO A 118
 None
 0.92A 1ya4B-3nbeA:
undetectable		 1ya4B-3nbeA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT GAMA

(Desulfovibrio
gigas) 		PF04358
(DsrC) 		4 PRO C  64
GLY C  87
LEU C  53
PRO C 101
 None
 0.91A 1ya4B-3or2C:
undetectable		 1ya4B-3or2C:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 279
GLY A 278
LYS A 274
LEU A 259
 None
 0.92A 1ya4B-3qtpA:
undetectable		 1ya4B-3qtpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy2 CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01111
(CKS) 		4 PRO A  55
LEU A  77
GLY A  78
LEU A  13
 None
 0.89A 1ya4B-3qy2A:
undetectable		 1ya4B-3qy2A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 PRO A 470
LEU A 500
GLY A 497
LEU A 513
 None
 0.75A 1ya4B-3rcnA:
undetectable		 1ya4B-3rcnA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 TRP A 682
GLY A 599
LYS A 621
LEU A 663
 None
NDP  A 802 (-3.7A)
NDP  A 802 (-2.5A)
None
 0.92A 1ya4B-3slkA:
2.1		 1ya4B-3slkA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 LEU A 187
GLY A 191
LEU A 203
PRO A 254
 None
 0.60A 1ya4B-3texA:
undetectable		 1ya4B-3texA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u78 LYSINE-SPECIFIC
DEMETHYLASE 7

(Homo sapiens) 		PF02373
(JmjC) 		4 PRO A 424
LEU A 428
GLY A 431
LEU A 414
 None
 0.82A 1ya4B-3u78A:
undetectable		 1ya4B-3u78A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT

(Homo sapiens) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		4 LEU A  90
GLY A  91
LEU A  88
PRO A 160
 None
 0.91A 1ya4B-3v4yA:
undetectable		 1ya4B-3v4yA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwn PUTATIVE
ACETYLGLUTAMATE
KINASE-LIKE PROTEIN

(Thermus
thermophilus) 		PF00696
(AA_kinase) 		4 PRO A 153
LEU A 100
GLY A 102
LEU A 143
 None
 0.76A 1ya4B-3wwnA:
undetectable		 1ya4B-3wwnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amm DYNE8

(Micromonospora
chersina) 		PF00698
(Acyl_transf_1) 		4 PRO A 644
LEU A 860
GLY A 856
LEU A 637
 None
 0.91A 1ya4B-4ammA:
undetectable		 1ya4B-4ammA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce5 AT-OMEGATA

(Aspergillus
terreus) 		PF01063
(Aminotran_4) 		4 PRO A 202
LEU A 187
GLY A 185
LEU A 204
 None
 0.90A 1ya4B-4ce5A:
undetectable		 1ya4B-4ce5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmf AMINOTRANSFERASE

([Nectria]
haematococca) 		PF01063
(Aminotran_4) 		4 PRO A 201
LEU A 186
GLY A 184
LEU A 203
 None
 0.90A 1ya4B-4cmfA:
undetectable		 1ya4B-4cmfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1e ALPHA-ACTININ-2

(Homo sapiens) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		4 LEU A 186
GLY A 183
LEU A 229
PRO A 240
 None
MLZ  A 181 ( 4.3A)
None
MLZ  A 239 ( 2.6A)
 0.90A 1ya4B-4d1eA:
undetectable		 1ya4B-4d1eA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dol AT1G53520

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		4 PRO A  30
LEU A 173
GLY A 172
LEU A 155
 None
 0.89A 1ya4B-4dolA:
undetectable		 1ya4B-4dolA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsp PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 PRO A 112
LEU A 183
GLY A 201
LEU A 149
 None
 0.77A 1ya4B-4fspA:
undetectable		 1ya4B-4fspA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb3 COAT PROTEIN 2

(Enterovirus B) 		PF00073
(Rhv) 		4 PRO 2  56
LEU 2  91
GLY 2  90
PRO 2 249
 None
 0.87A 1ya4B-4gb32:
undetectable		 1ya4B-4gb32:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		4 PRO L 445
LEU L 334
GLY L 337
PRO L 439
 None
 0.84A 1ya4B-4heaL:
0.0		 1ya4B-4heaL:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		4 LEU A 363
GLY A 360
LEU A  46
PRO A 127
 None
 0.90A 1ya4B-4rasA:
undetectable		 1ya4B-4rasA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlq BENZOATE-COENZYME A
LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PRO A  77
GLY A 229
LEU A 246
PRO A 237
 None
 0.81A 1ya4B-4rlqA:
undetectable		 1ya4B-4rlqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		4 LEU A 621
GLY A 620
LEU A 590
PRO A 533
 None
 0.84A 1ya4B-4s3pA:
2.6		 1ya4B-4s3pA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tll RECEPTOR SUBUNIT
GLUN2B

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 PRO B 117
LEU B 119
GLY B 291
LEU B 334
 None
 0.90A 1ya4B-4tllB:
undetectable		 1ya4B-4tllB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x1z VP1

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		4 PRO A 239
LEU A 528
GLY A 527
LEU A 507
 None
 0.89A 1ya4B-4x1zA:
undetectable		 1ya4B-4x1zA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 PRO A 735
LEU A 751
GLY A 749
LEU A 739
 None
 0.87A 1ya4B-4ztxA:
undetectable		 1ya4B-4ztxA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 361
GLY A 357
LEU A 299
PRO A 367
 None
 0.92A 1ya4B-5e8yA:
undetectable		 1ya4B-5e8yA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e94 ANTIBODY FAB
FRAGMENT HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO B 136
LEU B 199
GLY B 200
LEU B 148
 None
 0.93A 1ya4B-5e94B:
undetectable		 1ya4B-5e94B:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eks 3-DEHYDROQUINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF01761
(DHQ_synthase) 		4 PRO A 306
GLY A 249
LEU A 256
PRO A 302
 None
 0.92A 1ya4B-5eksA:
undetectable		 1ya4B-5eksA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		6 PRO A 342
LEU A 349
GLY A 352
LYS A 395
LEU A 399
PRO A 442
 None
 1.18A 1ya4B-5fv4A:
63.3		 1ya4B-5fv4A:
78.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		6 TRP A 339
PRO A 342
LEU A 349
GLY A 352
LEU A 399
PRO A 442
 None
 0.70A 1ya4B-5fv4A:
63.3		 1ya4B-5fv4A:
78.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hba UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF00386
(C1q) 		4 PRO A 108
LEU A  62
GLY A  60
LEU A 122
 None
 0.92A 1ya4B-5hbaA:
undetectable		 1ya4B-5hbaA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 LEU A1901
GLY A1900
LEU A1991
PRO A1876
 None
 0.92A 1ya4B-5i6gA:
undetectable		 1ya4B-5i6gA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 LEU A1901
GLY A1900
LEU A1991
PRO A1876
 None
 0.93A 1ya4B-5i6hA:
undetectable		 1ya4B-5i6hA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 LEU A1901
GLY A1900
LEU A1991
PRO A1876
 None
 0.93A 1ya4B-5i6iA:
2.4		 1ya4B-5i6iA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Candida
albicans) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		4 LEU A 255
GLY A 256
LEU A 253
PRO A 325
 None
 0.92A 1ya4B-5jpeA:
undetectable		 1ya4B-5jpeA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY

(Myxococcus
xanthus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PRO A 128
GLY A 120
LEU A 117
PRO A  23
 None
 0.90A 1ya4B-5k1sA:
undetectable		 1ya4B-5k1sA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		4 PRO A 446
LEU A 510
GLY A 511
LEU A 413
 None
 0.79A 1ya4B-5l2rA:
undetectable		 1ya4B-5l2rA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 PRO A1176
GLY A1060
LEU A1184
PRO A1053
 None
 0.83A 1ya4B-5l56A:
undetectable		 1ya4B-5l56A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL

(Homo sapiens) 		PF01180
(DHO_dh) 		4 LEU A 343
GLY A 339
LEU A 378
PRO A  91
 None
 0.92A 1ya4B-5mvdA:
undetectable		 1ya4B-5mvdA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen INTERFERON
REGULATORY FACTOR 9

(Mus musculus) 		no annotation 4 PRO A 336
LEU A 326
LEU A 373
PRO A 297
 None
 0.87A 1ya4B-5oenA:
undetectable		 1ya4B-5oenA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uff RBC36

(Petromyzon
marinus) 		no annotation 4 LEU A  85
GLY A  86
LEU A  64
PRO A 113
 None
 0.93A 1ya4B-5uffA:
undetectable		 1ya4B-5uffA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN

(Human
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		4 LEU A 113
GLY A 112
LEU A 533
PRO A 227
 None
 0.90A 1ya4B-5vylA:
undetectable		 1ya4B-5vylA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe7 ECF RNA POLYMERASE
SIGMA FACTOR SIGJ

(Mycobacterium
tuberculosis) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2)
PF12680
(SnoaL_2) 		4 LEU A 242
GLY A 250
LEU A  87
PRO A 295
 None
 0.91A 1ya4B-5xe7A:
2.0		 1ya4B-5xe7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY

(Thermobifida
fusca) 		no annotation 4 PRO M 136
LEU M 138
GLY M  10
LEU M 149
 U  J   2 ( 4.8A)
None
None
None
 0.93A 1ya4B-6c66M:
undetectable		 1ya4B-6c66M:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus) 		no annotation 4 PRO H 466
LEU H 359
GLY H 362
PRO H 459
 None
 0.86A 1ya4B-6cfwH:
0.1		 1ya4B-6cfwH:
9.75