SIMILAR PATTERNS OF AMINO ACIDS FOR 1YA4_A_CTXA1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens)
PF00135
(COesterase)
5 ALA A 237
PHE A 307
GLY A 210
SER A 203
LEU A 227
None
1.02A 1ya4A-1b41A:
46.3
1ya4A-1b41A:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus)
PF00135
(COesterase)
5 ALA A 237
PHE A 307
GLY A 210
SER A 203
LEU A 227
None
0.99A 1ya4A-1c2oA:
45.9
1ya4A-1c2oA:
36.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea)
PF00135
(COesterase)
5 GLY A 122
GLY A 123
SER A 209
LEU A 297
HIS A 449
CLL  A 801 (-4.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
CLL  A 801 (-4.8A)
1.00A 1ya4A-1cleA:
43.0
1ya4A-1cleA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa)
PF00135
(COesterase)
5 GLY A 122
GLY A 123
SER A 209
LEU A 297
HIS A 449
None
1.01A 1ya4A-1crlA:
40.0
1ya4A-1crlA:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa)
PF00135
(COesterase)
5 GLY A 123
GLY A 124
SER A 209
LEU A 304
HIS A 449
None
0.92A 1ya4A-1crlA:
40.0
1ya4A-1crlA:
30.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE


(Escherichia
coli)
PF00378
(ECH_1)
6 GLY A 109
GLY A 110
LEU A  28
SER A  29
LEU A  85
LEU A  71
2CP  A 270 ( 3.8A)
2CP  A 270 (-3.4A)
None
None
None
None
1.35A 1ya4A-1ef9A:
undetectable
1ya4A-1ef9A:
18.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica)
PF00135
(COesterase)
5 ALA A 234
PHE A 300
GLY A 207
SER A 200
LEU A 224
None
None
None
EMM  A1999 ( 1.4A)
None
0.95A 1ya4A-1gqrA:
52.5
1ya4A-1gqrA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa)
PF00135
(COesterase)
6 GLY A 122
GLY A 123
SER A 209
LEU A 127
LEU A 297
HIS A 449
None
1.21A 1ya4A-1gz7A:
40.0
1ya4A-1gz7A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa)
PF00135
(COesterase)
5 GLY A 123
GLY A 124
SER A 209
LEU A 297
HIS A 449
None
0.77A 1ya4A-1gz7A:
40.0
1ya4A-1gz7A:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E


(Trichoderma
reesei)
PF01532
(Glyco_hydro_47)
5 GLY A 313
GLY A 312
SER A 397
LEU A 293
SER A 294
None
0.91A 1ya4A-1hcuA:
undetectable
1ya4A-1hcuA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT


(Escherichia
coli)
PF00701
(DHDPS)
6 ALA A  10
GLY A  46
GLY A  45
LEU A  12
LEU A  13
LEU A  22
None
3PY  A 802 (-3.5A)
None
None
None
None
1.36A 1ya4A-1hl2A:
undetectable
1ya4A-1hl2A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8m SIGNAL RECOGNITION
54 KDA PROTEIN


(Acidianus
ambivalens)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 ALA F 263
GLY F 257
GLY F 256
SER F  81
LEU F   7
None
0.88A 1ya4A-1j8mF:
undetectable
1ya4A-1j8mF:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa)
PF00282
(Pyridoxal_deC)
5 ALA A 185
GLY A 203
GLY A 202
LEU A 156
LEU A 157
None
0.89A 1ya4A-1js6A:
2.3
1ya4A-1js6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA


(Escherichia
coli)
no annotation 5 ALA A 188
GLY A 152
GLY A 153
LEU A 157
LEU A 160
None
0.96A 1ya4A-1onsA:
undetectable
1ya4A-1onsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgy BETA-LACTAMASE

(Citrobacter
freundii)
PF00144
(Beta-lactamase)
6 ALA A 110
GLY A  74
GLY A  75
LEU A  85
LEU A 254
LEU A 106
None
1.20A 1ya4A-1rgyA:
undetectable
1ya4A-1rgyA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME


(Thermotoga
maritima)
PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical)
5 ALA A 125
GLY A 147
GLY A 148
LEU A 382
LEU A 142
None
0.76A 1ya4A-1xzqA:
undetectable
1ya4A-1xzqA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Entamoeba
histolytica)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
6 ALA A 196
GLY A 211
SER A 182
LEU A 180
MET A 181
LEU A 314
None
1.38A 1ya4A-1y9aA:
undetectable
1ya4A-1y9aA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE


(Saccharomyces
cerevisiae)
PF00343
(Phosphorylase)
5 GLY A 686
GLY A 685
LEU A 805
LEU A 798
LEU A 502
None
1.04A 1ya4A-1ygpA:
3.4
1ya4A-1ygpA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 GLY A 323
GLY A 324
LEU A 291
LEU A 175
HIS A 158
None
None
None
None
NI  A 381 (-3.4A)
0.99A 1ya4A-1ysjA:
undetectable
1ya4A-1ysjA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE


(Paracoccus
denitrificans)
PF00155
(Aminotran_1_2)
5 GLY A 231
GLY A 227
LEU A 323
LEU A 331
MET A 330
None
1.03A 1ya4A-2ay9A:
undetectable
1ya4A-2ay9A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon)
PF07859
(Abhydrolase_3)
5 GLY A  83
SER A 154
LEU A 210
LEU A 195
HIS A 281
None
0.87A 1ya4A-2c7bA:
19.0
1ya4A-2c7bA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)


(Arabidopsis
thaliana)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc)
5 ALA A 396
GLY A 391
LEU A 325
MET A 326
LEU A 384
None
0.99A 1ya4A-2fgeA:
undetectable
1ya4A-2fgeA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II


(Thermotoga
maritima)
PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C)
5 ALA A  24
GLY A 240
GLY A 241
LEU A 277
LEU A 266
None
1.02A 1ya4A-2hruA:
undetectable
1ya4A-2hruA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja9 EXOSOME COMPLEX
EXONUCLEASE RRP40


(Saccharomyces
cerevisiae)
PF15985
(KH_6)
5 ALA A 101
GLY A 148
LEU A  97
SER A  96
LEU A  88
None
0.97A 1ya4A-2ja9A:
undetectable
1ya4A-2ja9A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jug TUBC PROTEIN

(Archangium
disciforme)
no annotation 5 GLY A  46
GLY A  47
LEU A  21
LEU A  55
HIS A  50
None
1.02A 1ya4A-2jugA:
undetectable
1ya4A-2jugA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mxz L-ALANYL-D-GLUTAMATE
PEPTIDASE


(Escherichia
virus T5)
PF13539
(Peptidase_M15_4)
5 ALA A  71
PHE A  74
GLY A 132
GLY A 131
LEU A 108
None
0.98A 1ya4A-2mxzA:
undetectable
1ya4A-2mxzA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha)
PF07859
(Abhydrolase_3)
5 GLY A  92
GLY A  93
SER A 169
LEU A  22
HIS A 306
4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
0.82A 1ya4A-2o7rA:
18.4
1ya4A-2o7rA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE


(Salmonella
enterica)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N)
5 ALA A 286
GLY A 280
GLY A 279
LEU A  46
LEU A  75
None
0.83A 1ya4A-2p2mA:
3.0
1ya4A-2p2mA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7n PATHOGENICITY ISLAND
1 EFFECTOR PROTEIN


(Chromobacterium
violaceum)
PF06511
(IpaD)
5 ALA A 153
GLY A 161
LEU A 374
SER A 373
LEU A 378
None
1.01A 1ya4A-2p7nA:
undetectable
1ya4A-2p7nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus)
PF04960
(Glutaminase)
5 ALA A 258
GLY A 277
LEU A 296
SER A 300
LEU A 295
None
1.01A 1ya4A-2pbyA:
undetectable
1ya4A-2pbyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkb SERINE
DEHYDRATASE-LIKE


(Homo sapiens)
PF00291
(PALP)
5 ALA A 172
GLY A 176
GLY A 175
LEU A 229
LEU A 219
PLP  A 400 ( 4.8A)
PLP  A 400 (-2.9A)
PLP  A 400 (-3.4A)
K  A 401 (-4.6A)
None
1.00A 1ya4A-2rkbA:
undetectable
1ya4A-2rkbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uun C-PHYCOCYANIN

(Leptolyngbya
sp.)
PF00502
(Phycobilisome)
5 ALA B 137
GLY B 132
GLY B 130
SER B  53
LEU B  59
None
0.94A 1ya4A-2uunB:
undetectable
1ya4A-2uunB:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqp POLYSIALIC ACID
CAPSULE BIOSYNTHESIS
PROTEIN SIAC


(Neisseria
meningitidis)
PF03102
(NeuB)
PF08666
(SAF)
5 ALA A  37
GLY A  27
LEU A  88
LEU A 120
HIS A  57
None
0.94A 1ya4A-2wqpA:
undetectable
1ya4A-2wqpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE


(Thermus
thermophilus)
PF01063
(Aminotran_4)
5 ALA A  76
GLY A  32
GLY A  33
LEU A  79
LEU A  70
None
0.97A 1ya4A-2zgiA:
undetectable
1ya4A-2zgiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE


(Streptomyces
avermitilis)
PF00067
(p450)
5 ALA A 256
GLY A 368
GLY A 369
LEU A 133
LEU A 128
None
1.03A 1ya4A-3abbA:
undetectable
1ya4A-3abbA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis)
PF13460
(NAD_binding_10)
5 ALA A 129
GLY A  75
GLY A  74
SER A 105
LEU A 153
None
0.89A 1ya4A-3dqpA:
3.4
1ya4A-3dqpA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1


(Prunus dulcis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 ALA A  42
GLY A  35
GLY A 104
SER A 107
LEU A 201
None
FAD  A 522 (-3.3A)
None
None
None
0.85A 1ya4A-3gdnA:
undetectable
1ya4A-3gdnA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN


(Ralstonia
solanacearum)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 ALA A 242
PHE A 203
GLY A 257
LEU A 236
LEU A 226
None
1.01A 1ya4A-3ghyA:
undetectable
1ya4A-3ghyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN


(Ralstonia
solanacearum)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 PHE A 203
GLY A 257
LEU A 236
MET A 211
LEU A 226
None
0.83A 1ya4A-3ghyA:
undetectable
1ya4A-3ghyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
5 GLY A  89
GLY A  90
SER A 157
LEU A 192
HIS A 281
None
0.64A 1ya4A-3k6kA:
16.8
1ya4A-3k6kA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1


(Homo sapiens)
PF00135
(COesterase)
6 ALA A1093
GLY A1142
SER A1221
LEU A1363
MET A1364
HIS A1468
None
WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
WW2  A 193 (-3.8A)
None
None
1.04A 1ya4A-3k9bA:
69.0
1ya4A-3k9bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1


(Homo sapiens)
PF00135
(COesterase)
9 ALA A1093
PHE A1101
GLY A1142
GLY A1143
SER A1221
LEU A1363
MET A1364
LEU A1388
HIS A1468
None
None
WW2  A 193 (-3.4A)
WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
WW2  A 193 (-3.8A)
None
None
None
0.38A 1ya4A-3k9bA:
69.0
1ya4A-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4a PUTATIVE TYPE I
TOPOISOMERASE


(Deinococcus
radiodurans)
PF01028
(Topoisom_I)
5 ALA A 248
GLY A 243
LEU A 328
LEU A  95
LEU A 102
None
1.02A 1ya4A-3m4aA:
undetectable
1ya4A-3m4aA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA


(Escherichia
coli)
PF00873
(ACR_tran)
6 ALA A1013
PHE A 461
GLY A 395
GLY A 394
LEU A 338
LEU A  39
None
1.28A 1ya4A-3ne5A:
undetectable
1ya4A-3ne5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)


(Kluyveromyces
lactis)
PF03159
(XRN_N)
5 GLY A 937
GLY A 936
LEU A1233
SER A1234
LEU A1231
None
0.91A 1ya4A-3pieA:
undetectable
1ya4A-3pieA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE


(Homo sapiens)
PF00282
(Pyridoxal_deC)
5 ALA A 185
GLY A 203
GLY A 202
LEU A 156
LEU A 157
None
0.90A 1ya4A-3rblA:
undetectable
1ya4A-3rblA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 ALA A  42
GLY A  35
GLY A 104
SER A 107
LEU A 201
None
FAD  A 773 (-3.4A)
None
None
None
0.86A 1ya4A-3redA:
undetectable
1ya4A-3redA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG


(Cupriavidus
necator)
PF00374
(NiFeSe_Hases)
5 ALA L 532
GLY L 323
GLY L 324
MET L 409
LEU L 327
None
1.03A 1ya4A-3rgwL:
undetectable
1ya4A-3rgwL:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE


(Proteus
mirabilis)
PF02126
(PTE)
5 ALA A  95
GLY A 168
SER A 226
MET A 196
LEU A 214
ZN  A 367 ( 4.6A)
None
None
None
None
1.01A 1ya4A-3rhgA:
undetectable
1ya4A-3rhgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2


(Saccharopolyspora
spinosa)
PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2)
6 ALA A 569
GLY A 516
GLY A 517
LEU A 567
SER A 566
LEU A 554
None
NDP  A 802 (-3.3A)
None
None
None
None
1.45A 1ya4A-3slkA:
2.6
1ya4A-3slkA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti)
PF00294
(PfkB)
5 ALA A 304
PHE A 213
GLY A 287
LEU A  71
SER A  70
None
1.00A 1ya4A-3uboA:
undetectable
1ya4A-3uboA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE


(Caldicellulosiruptor
saccharolyticus)
PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N)
5 GLY A 449
LEU A 508
SER A 506
LEU A 512
LEU A 529
None
1.03A 1ya4A-3wiqA:
undetectable
1ya4A-3wiqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1


(Aspergillus
oryzae)
PF07519
(Tannase)
5 GLY A 124
GLY A 125
SER A 203
LEU A 126
HIS A 457
None
0.85A 1ya4A-3wmtA:
11.8
1ya4A-3wmtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE


(Pseudomonas sp.
VM15C)
no annotation 5 ALA A 181
GLY A 175
GLY A 170
LEU A 168
LEU A 313
None
1.00A 1ya4A-3wweA:
16.6
1ya4A-3wweA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR6

(Archaeoglobus
fulgidus)
PF03787
(RAMPs)
5 ALA H 320
PHE H 148
GLY H 141
LEU H 317
LEU H 316
None
None
U  I  26 ( 3.2A)
None
None
0.93A 1ya4A-3x1lH:
undetectable
1ya4A-3x1lH:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT


(Torpedo
marmorata)
PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb)
5 PHE E  99
SER E 125
LEU E  39
LEU E  34
LEU E 212
None
1.04A 1ya4A-4aq9E:
undetectable
1ya4A-4aq9E:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae)
PF00135
(COesterase)
5 GLY A 134
GLY A 135
SER A 220
SER A 309
HIS A 465
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
1.03A 1ya4A-4be9A:
41.2
1ya4A-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae)
PF00135
(COesterase)
5 GLY A 134
GLY A 135
SER A 220
SER A 311
HIS A 465
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
1.00A 1ya4A-4be9A:
41.2
1ya4A-4be9A:
32.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens)
PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin)
5 ALA A 648
GLY A 742
GLY A 589
LEU A 599
LEU A 618
None
1.00A 1ya4A-4duuA:
undetectable
1ya4A-4duuA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyi RIO2 KINASE

(Chaetomium
thermophilum)
PF01163
(RIO1)
PF09202
(Rio2_N)
5 GLY A  79
GLY A  80
LEU A  19
LEU A  86
HIS A 185
None
None
None
None
EDO  A 403 (-4.1A)
1.02A 1ya4A-4gyiA:
undetectable
1ya4A-4gyiA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 ALA A  33
GLY A  26
GLY A  98
LEU A 216
HIS A 506
None
FAD  A 601 (-3.2A)
CME  A 102 ( 3.4A)
None
FAD  A 601 (-4.6A)
0.91A 1ya4A-4ha6A:
undetectable
1ya4A-4ha6A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA


(Pseudomonas sp.
C18)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
5 PHE A 224
GLY A 251
LEU A 307
MET A 306
LEU A 170
None
None
15O  A 503 ( 4.6A)
None
None
0.97A 1ya4A-4hjlA:
undetectable
1ya4A-4hjlA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA


(Pseudomonas sp.
C18)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
5 PHE A 224
SER A 305
LEU A 307
MET A 306
LEU A 170
None
None
15O  A 503 ( 4.6A)
None
None
1.04A 1ya4A-4hjlA:
undetectable
1ya4A-4hjlA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4n INTRACELLULAR
PROTEASE/AMIDASE


(Vibrio cholerae)
no annotation 6 ALA A 192
GLY A 156
GLY A 157
LEU A 161
LEU A 164
MET A 162
None
1.18A 1ya4A-4i4nA:
2.4
1ya4A-4i4nA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN


(Streptococcus
gordonii)
no annotation 5 ALA D 201
GLY D 307
LEU D 215
SER D 287
LEU D 350
None
0.98A 1ya4A-4igbD:
undetectable
1ya4A-4igbD:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN


(Streptococcus
pneumoniae)
PF01497
(Peripla_BP_2)
5 GLY A  66
SER A 308
LEU A 161
SER A 160
LEU A 177
None
0.87A 1ya4A-4jccA:
undetectable
1ya4A-4jccA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jot ENOYL-COA HYDRATASE,
PUTATIVE


(Deinococcus
radiodurans)
PF00378
(ECH_1)
5 GLY A 153
GLY A 154
LEU A 141
SER A 140
LEU A 187
None
0.90A 1ya4A-4jotA:
2.4
1ya4A-4jotA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC


([Bacillus]
selenitireducens)
PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N)
5 PHE A 332
GLY A 318
GLY A 321
LEU A  73
SER A  74
BGC  A 801 (-3.7A)
None
None
None
None
0.97A 1ya4A-4ktpA:
undetectable
1ya4A-4ktpA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus)
PF08659
(KR)
5 ALA A 318
SER A 309
LEU A 307
LEU A 348
HIS A 304
None
NDP  A 601 (-2.4A)
None
None
None
0.94A 1ya4A-4l4xA:
2.7
1ya4A-4l4xA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE


(Caldalkalibacillus
thermarum)
PF07992
(Pyr_redox_2)
5 ALA A  18
GLY A 106
LEU A 103
LEU A  35
LEU A  98
None
0.88A 1ya4A-4nwzA:
undetectable
1ya4A-4nwzA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E


(Vibrio cholerae)
PF02508
(Rnf-Nqr)
PF03116
(NQR2_RnfD_RnfE)
6 ALA B 207
GLY E 189
SER E 192
LEU B 202
SER B 349
LEU B 391
None
1.29A 1ya4A-4p6vB:
2.6
1ya4A-4p6vB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plh MALATE DEHYDROGENASE

(Apicomplexa)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
6 ALA A 259
GLY A 176
GLY A 175
SER A 302
LEU A 261
LEU A 291
None
1.42A 1ya4A-4plhA:
undetectable
1ya4A-4plhA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus)
PF00135
(COesterase)
5 ALA A 234
PHE A 300
GLY A 207
SER A 200
LEU A 224
None
0.94A 1ya4A-4qwwA:
50.0
1ya4A-4qwwA:
35.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12)
PF00756
(Esterase)
5 GLY A 128
GLY A 130
LEU A 134
LEU A  47
LEU A 102
None
1.01A 1ya4A-4rgyA:
15.3
1ya4A-4rgyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12)
PF00756
(Esterase)
5 GLY A 130
LEU A 134
LEU A  47
LEU A 102
HIS A  49
None
0.98A 1ya4A-4rgyA:
15.3
1ya4A-4rgyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT


(Desulfovibrio
fructosivorans)
PF00374
(NiFeSe_Hases)
6 PHE Q 390
GLY Q 423
SER Q 420
LEU Q 411
SER Q 412
LEU Q 408
None
1.38A 1ya4A-4upeQ:
undetectable
1ya4A-4upeQ:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE


(Streptomyces
bottropensis)
PF00296
(Bac_luciferase)
5 ALA A 187
GLY A  74
GLY A  75
SER A 173
LEU A 137
None
0.87A 1ya4A-4us5A:
undetectable
1ya4A-4us5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfi CUTINASE

(Saccharomonospora
viridis)
PF03403
(PAF-AH_p_II)
5 PHE A 106
GLY A 178
GLY A 179
LEU A 183
HIS A 254
None
1.03A 1ya4A-4wfiA:
14.6
1ya4A-4wfiA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum)
PF07859
(Abhydrolase_3)
5 ALA A  30
GLY A  87
GLY A  88
SER A 159
HIS A 283
None
0.57A 1ya4A-4ypvA:
19.1
1ya4A-4ypvA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN


(Chaetomium
thermophilum)
PF09439
(SRPRB)
5 GLY B 327
GLY B 326
LEU B 246
LEU B 199
LEU B 267
None
1.03A 1ya4A-5ck3B:
2.4
1ya4A-5ck3B:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110)
5 GLY A  67
GLY A  66
SER A 422
LEU A  74
SER A  73
None
0.98A 1ya4A-5djwA:
undetectable
1ya4A-5djwA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML


(Bacillus
velezensis)
PF13847
(Methyltransf_31)
5 GLY A 221
GLY A 220
LEU A 232
MET A 233
LEU A 242
None
0.99A 1ya4A-5dlyA:
3.0
1ya4A-5dlyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esr HALOALKANE
DEHALOGENASE


(Caulobacter
vibrioides)
PF00561
(Abhydrolase_1)
5 GLY A 125
GLY A 126
LEU A 119
LEU A 132
LEU A 234
None
0.94A 1ya4A-5esrA:
12.3
1ya4A-5esrA:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE


(Sus scrofa)
PF00135
(COesterase)
7 ALA A  76
PHE A  84
GLY A 125
GLY A 126
SER A 204
MET A 345
HIS A 449
None
0.59A 1ya4A-5fv4A:
66.5
1ya4A-5fv4A:
78.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4g VCP-LIKE ATPASE

(Thermoplasma
acidophilum)
PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
6 ALA A 520
GLY A 470
LEU A 517
LEU A 472
LEU A 516
HIS A 648
None
1.24A 1ya4A-5g4gA:
undetectable
1ya4A-5g4gA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
5 GLY A 108
GLY A 109
SER A 188
LEU A  24
HIS A 317
TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
0.59A 1ya4A-5hc4A:
19.0
1ya4A-5hc4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
5 ALA A  64
GLY A 126
GLY A 127
SER A 201
HIS A 333
None
0.65A 1ya4A-5iq0A:
19.5
1ya4A-5iq0A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kt0 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE


(Trichormus
variabilis)
PF01113
(DapB_N)
PF05173
(DapB_C)
5 PHE A 173
LEU A 303
SER A 302
LEU A 156
LEU A 168
None
1.00A 1ya4A-5kt0A:
3.3
1ya4A-5kt0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA


(Escherichia
coli)
PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5)
5 ALA A 234
GLY A 268
GLY A 267
LEU A 168
MET A 204
None
0.98A 1ya4A-5lm7A:
undetectable
1ya4A-5lm7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwn TYPE VI SECRETION
PROTEIN


(Escherichia
coli)
PF05936
(T6SS_VasE)
5 ALA A 286
GLY A 273
LEU A 305
SER A 304
LEU A 204
None
1.01A 1ya4A-5mwnA:
undetectable
1ya4A-5mwnA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE


(Xenopus
tropicalis)
no annotation 5 GLY A  61
SER A  65
SER A 157
LEU A 139
HIS A 124
AR6  A 401 (-3.3A)
None
EDO  A 406 (-2.6A)
None
None
0.97A 1ya4A-5oj7A:
undetectable
1ya4A-5oj7A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w40 POPP2 PROTEIN

(Ralstonia
solanacearum)
PF03421
(Acetyltransf_14)
5 GLY A 385
SER A 390
LEU A 324
SER A 325
LEU A 281
None
None
SCY  A 321 ( 4.8A)
SCY  A 321 ( 3.0A)
COA  A 502 (-4.5A)
1.00A 1ya4A-5w40A:
undetectable
1ya4A-5w40A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8o HOMOSERINE
O-ACETYLTRANSFERASE


(Mycolicibacterium
hassiacum)
PF00561
(Abhydrolase_1)
6 GLY A 159
GLY A 160
LEU A 164
LEU A 289
LEU A 327
HIS A 350
None
1.28A 1ya4A-5w8oA:
12.7
1ya4A-5w8oA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8p HOMOSERINE
O-ACETYLTRANSFERASE


(Mycobacteroides
abscessus)
PF00561
(Abhydrolase_1)
6 GLY A 162
GLY A 163
LEU A 167
LEU A 296
LEU A 334
HIS A 357
None
1.26A 1ya4A-5w8pA:
12.5
1ya4A-5w8pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2


(Homo sapiens)
no annotation 5 ALA Q  44
GLY Q  49
LEU i 228
SER i 231
LEU i 175
None
1.01A 1ya4A-5xtcQ:
undetectable
1ya4A-5xtcQ:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14


(Saccharomyces
cerevisiae)
PF00782
(DSPc)
PF14671
(DSPn)
5 ALA A 352
GLY A 267
SER A 260
LEU A 359
LEU A 249
None
0.95A 1ya4A-5xw5A:
undetectable
1ya4A-5xw5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE


(Sorghum bicolor)
no annotation 5 ALA A 267
GLY A 348
GLY A 300
LEU A 354
LEU A  22
None
0.96A 1ya4A-6at7A:
undetectable
1ya4A-6at7A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d79 SULFATE TRANSPORTER
CYSZ


(Pseudomonas
fragi)
no annotation 5 ALA A 229
PHE A 236
GLY A 209
GLY A 210
LEU A 214
None
1.00A 1ya4A-6d79A:
undetectable
1ya4A-6d79A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2


(Aspergillus
oryzae)
no annotation 5 GLY A  90
GLY A  91
SER A 169
LEU A  92
HIS A 421
None
0.86A 1ya4A-6g21A:
12.5
1ya4A-6g21A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)


(Propionibacterium
freudenreichii)
PF01642
(MM_CoA_mutase)
5 GLY B 198
SER B 135
LEU B 195
LEU B 137
LEU B 154
None
0.96A 1ya4A-6reqB:
undetectable
1ya4A-6reqB:
24.19