SIMILAR PATTERNS OF AMINO ACIDS FOR 1YA4_A_CTXA1_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1b41 | ACETYLCHOLINESTERASE (Homo sapiens) |
PF00135(COesterase) | 5 | ALA A 237PHE A 307GLY A 210SER A 203LEU A 227 | None | 1.02A | 1ya4A-1b41A:46.3 | 1ya4A-1b41A:36.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1c2o | ACETYLCHOLINESTERASE (Electrophoruselectricus) |
PF00135(COesterase) | 5 | ALA A 237PHE A 307GLY A 210SER A 203LEU A 227 | None | 0.99A | 1ya4A-1c2oA:45.9 | 1ya4A-1c2oA:36.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1cle | CHOLESTEROL ESTERASE ([Candida]cylindracea) |
PF00135(COesterase) | 5 | GLY A 122GLY A 123SER A 209LEU A 297HIS A 449 | CLL A 801 (-4.3A)CLL A 801 (-3.3A)CLL A 801 ( 2.8A)NoneCLL A 801 (-4.8A) | 1.00A | 1ya4A-1cleA:43.0 | 1ya4A-1cleA:30.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1crl | LIPASE (Diutina rugosa) |
PF00135(COesterase) | 5 | GLY A 122GLY A 123SER A 209LEU A 297HIS A 449 | None | 1.01A | 1ya4A-1crlA:40.0 | 1ya4A-1crlA:30.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1crl | LIPASE (Diutina rugosa) |
PF00135(COesterase) | 5 | GLY A 123GLY A 124SER A 209LEU A 304HIS A 449 | None | 0.92A | 1ya4A-1crlA:40.0 | 1ya4A-1crlA:30.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ef9 | METHYLMALONYL COADECARBOXYLASE (Escherichiacoli) |
PF00378(ECH_1) | 6 | GLY A 109GLY A 110LEU A 28SER A 29LEU A 85LEU A 71 | 2CP A 270 ( 3.8A)2CP A 270 (-3.4A)NoneNoneNoneNone | 1.35A | 1ya4A-1ef9A:undetectable | 1ya4A-1ef9A:18.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gqr | ACETYLCHOLINESTERASE (Tetronarcecalifornica) |
PF00135(COesterase) | 5 | ALA A 234PHE A 300GLY A 207SER A 200LEU A 224 | NoneNoneNoneEMM A1999 ( 1.4A)None | 0.95A | 1ya4A-1gqrA:52.5 | 1ya4A-1gqrA:37.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gz7 | LIPASE 2 (Diutina rugosa) |
PF00135(COesterase) | 6 | GLY A 122GLY A 123SER A 209LEU A 127LEU A 297HIS A 449 | None | 1.21A | 1ya4A-1gz7A:40.0 | 1ya4A-1gz7A:31.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gz7 | LIPASE 2 (Diutina rugosa) |
PF00135(COesterase) | 5 | GLY A 123GLY A 124SER A 209LEU A 297HIS A 449 | None | 0.77A | 1ya4A-1gz7A:40.0 | 1ya4A-1gz7A:31.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hcu | ALPHA-1,2-MANNOSIDASE (Trichodermareesei) |
PF01532(Glyco_hydro_47) | 5 | GLY A 313GLY A 312SER A 397LEU A 293SER A 294 | None | 0.91A | 1ya4A-1hcuA:undetectable | 1ya4A-1hcuA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hl2 | N-ACETYLNEURAMINATELYASE SUBUNIT (Escherichiacoli) |
PF00701(DHDPS) | 6 | ALA A 10GLY A 46GLY A 45LEU A 12LEU A 13LEU A 22 | None3PY A 802 (-3.5A)NoneNoneNoneNone | 1.36A | 1ya4A-1hl2A:undetectable | 1ya4A-1hl2A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j8m | SIGNAL RECOGNITION54 KDA PROTEIN (Acidianusambivalens) |
PF00448(SRP54)PF02881(SRP54_N) | 5 | ALA F 263GLY F 257GLY F 256SER F 81LEU F 7 | None | 0.88A | 1ya4A-1j8mF:undetectable | 1ya4A-1j8mF:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js6 | DOPA DECARBOXYLASE (Sus scrofa) |
PF00282(Pyridoxal_deC) | 5 | ALA A 185GLY A 203GLY A 202LEU A 156LEU A 157 | None | 0.89A | 1ya4A-1js6A:2.3 | 1ya4A-1js6A:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ons | CHAPERONE PROTEINHCHA (Escherichiacoli) |
no annotation | 5 | ALA A 188GLY A 152GLY A 153LEU A 157LEU A 160 | None | 0.96A | 1ya4A-1onsA:undetectable | 1ya4A-1onsA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rgy | BETA-LACTAMASE (Citrobacterfreundii) |
PF00144(Beta-lactamase) | 6 | ALA A 110GLY A 74GLY A 75LEU A 85LEU A 254LEU A 106 | None | 1.20A | 1ya4A-1rgyA:undetectable | 1ya4A-1rgyA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xzq | PROBABLE TRNAMODIFICATION GTPASETRME (Thermotogamaritima) |
PF01926(MMR_HSR1)PF10396(TrmE_N)PF12631(MnmE_helical) | 5 | ALA A 125GLY A 147GLY A 148LEU A 382LEU A 142 | None | 0.76A | 1ya4A-1xzqA:undetectable | 1ya4A-1xzqA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y9a | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Entamoebahistolytica) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | ALA A 196GLY A 211SER A 182LEU A 180MET A 181LEU A 314 | None | 1.38A | 1ya4A-1y9aA:undetectable | 1ya4A-1y9aA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ygp | YEAST GLYCOGENPHOSPHORYLASE (Saccharomycescerevisiae) |
PF00343(Phosphorylase) | 5 | GLY A 686GLY A 685LEU A 805LEU A 798LEU A 502 | None | 1.04A | 1ya4A-1ygpA:3.4 | 1ya4A-1ygpA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ysj | PROTEIN YXEP (Bacillussubtilis) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | GLY A 323GLY A 324LEU A 291LEU A 175HIS A 158 | NoneNoneNoneNone NI A 381 (-3.4A) | 0.99A | 1ya4A-1ysjA:undetectable | 1ya4A-1ysjA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ay9 | AROMATIC AMINO ACIDAMINOTRANSFERASE (Paracoccusdenitrificans) |
PF00155(Aminotran_1_2) | 5 | GLY A 231GLY A 227LEU A 323LEU A 331MET A 330 | None | 1.03A | 1ya4A-2ay9A:undetectable | 1ya4A-2ay9A:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c7b | CARBOXYLESTERASE (unculturedarchaeon) |
PF07859(Abhydrolase_3) | 5 | GLY A 83SER A 154LEU A 210LEU A 195HIS A 281 | None | 0.87A | 1ya4A-2c7bA:19.0 | 1ya4A-2c7bA:24.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fge | ZINC METALLOPROTEASE(INSULINASE FAMILY) (Arabidopsisthaliana) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 5 | ALA A 396GLY A 391LEU A 325MET A 326LEU A 384 | None | 0.99A | 1ya4A-2fgeA:undetectable | 1ya4A-2fgeA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hru | PHOSPHORIBOSYLFORMYLGLYCINAMIDINESYNTHASE II (Thermotogamaritima) |
PF00586(AIRS)PF02769(AIRS_C)PF16904(PurL_C) | 5 | ALA A 24GLY A 240GLY A 241LEU A 277LEU A 266 | None | 1.02A | 1ya4A-2hruA:undetectable | 1ya4A-2hruA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ja9 | EXOSOME COMPLEXEXONUCLEASE RRP40 (Saccharomycescerevisiae) |
PF15985(KH_6) | 5 | ALA A 101GLY A 148LEU A 97SER A 96LEU A 88 | None | 0.97A | 1ya4A-2ja9A:undetectable | 1ya4A-2ja9A:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jug | TUBC PROTEIN (Archangiumdisciforme) |
no annotation | 5 | GLY A 46GLY A 47LEU A 21LEU A 55HIS A 50 | None | 1.02A | 1ya4A-2jugA:undetectable | 1ya4A-2jugA:11.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mxz | L-ALANYL-D-GLUTAMATEPEPTIDASE (Escherichiavirus T5) |
PF13539(Peptidase_M15_4) | 5 | ALA A 71PHE A 74GLY A 132GLY A 131LEU A 108 | None | 0.98A | 1ya4A-2mxzA:undetectable | 1ya4A-2mxzA:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o7r | CXE CARBOXYLESTERASE (Actinidiaeriantha) |
PF07859(Abhydrolase_3) | 5 | GLY A 92GLY A 93SER A 169LEU A 22HIS A 306 | 4PA A 369 (-3.5A)4PA A 369 (-3.6A)4PA A 369 (-1.8A)None4PA A 369 (-4.8A) | 0.82A | 1ya4A-2o7rA:18.4 | 1ya4A-2o7rA:24.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p2m | ACETYL-COENZYME ASYNTHETASE (Salmonellaenterica) |
PF00501(AMP-binding)PF13193(AMP-binding_C)PF16177(ACAS_N) | 5 | ALA A 286GLY A 280GLY A 279LEU A 46LEU A 75 | None | 0.83A | 1ya4A-2p2mA:3.0 | 1ya4A-2p2mA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p7n | PATHOGENICITY ISLAND1 EFFECTOR PROTEIN (Chromobacteriumviolaceum) |
PF06511(IpaD) | 5 | ALA A 153GLY A 161LEU A 374SER A 373LEU A 378 | None | 1.01A | 1ya4A-2p7nA:undetectable | 1ya4A-2p7nA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pby | GLUTAMINASE (Geobacilluskaustophilus) |
PF04960(Glutaminase) | 5 | ALA A 258GLY A 277LEU A 296SER A 300LEU A 295 | None | 1.01A | 1ya4A-2pbyA:undetectable | 1ya4A-2pbyA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rkb | SERINEDEHYDRATASE-LIKE (Homo sapiens) |
PF00291(PALP) | 5 | ALA A 172GLY A 176GLY A 175LEU A 229LEU A 219 | PLP A 400 ( 4.8A)PLP A 400 (-2.9A)PLP A 400 (-3.4A) K A 401 (-4.6A)None | 1.00A | 1ya4A-2rkbA:undetectable | 1ya4A-2rkbA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uun | C-PHYCOCYANIN (Leptolyngbyasp.) |
PF00502(Phycobilisome) | 5 | ALA B 137GLY B 132GLY B 130SER B 53LEU B 59 | None | 0.94A | 1ya4A-2uunB:undetectable | 1ya4A-2uunB:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wqp | POLYSIALIC ACIDCAPSULE BIOSYNTHESISPROTEIN SIAC (Neisseriameningitidis) |
PF03102(NeuB)PF08666(SAF) | 5 | ALA A 37GLY A 27LEU A 88LEU A 120HIS A 57 | None | 0.94A | 1ya4A-2wqpA:undetectable | 1ya4A-2wqpA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zgi | PUTATIVE4-AMINO-4-DEOXYCHORISMATE LYASE (Thermusthermophilus) |
PF01063(Aminotran_4) | 5 | ALA A 76GLY A 32GLY A 33LEU A 79LEU A 70 | None | 0.97A | 1ya4A-2zgiA:undetectable | 1ya4A-2zgiA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abb | CYTOCHROME P450HYDROXYLASE (Streptomycesavermitilis) |
PF00067(p450) | 5 | ALA A 256GLY A 368GLY A 369LEU A 133LEU A 128 | None | 1.03A | 1ya4A-3abbA:undetectable | 1ya4A-3abbA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dqp | OXIDOREDUCTASE YLBE (Lactococcuslactis) |
PF13460(NAD_binding_10) | 5 | ALA A 129GLY A 75GLY A 74SER A 105LEU A 153 | None | 0.89A | 1ya4A-3dqpA:3.4 | 1ya4A-3dqpA:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdn | R-OXYNITRILE LYASEISOENZYME 1 (Prunus dulcis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | ALA A 42GLY A 35GLY A 104SER A 107LEU A 201 | NoneFAD A 522 (-3.3A)NoneNoneNone | 0.85A | 1ya4A-3gdnA:undetectable | 1ya4A-3gdnA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ghy | KETOPANTOATEREDUCTASE PROTEIN (Ralstoniasolanacearum) |
PF02558(ApbA)PF08546(ApbA_C) | 5 | ALA A 242PHE A 203GLY A 257LEU A 236LEU A 226 | None | 1.01A | 1ya4A-3ghyA:undetectable | 1ya4A-3ghyA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ghy | KETOPANTOATEREDUCTASE PROTEIN (Ralstoniasolanacearum) |
PF02558(ApbA)PF08546(ApbA_C) | 5 | PHE A 203GLY A 257LEU A 236MET A 211LEU A 226 | None | 0.83A | 1ya4A-3ghyA:undetectable | 1ya4A-3ghyA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k6k | ESTERASE/LIPASE (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | GLY A 89GLY A 90SER A 157LEU A 192HIS A 281 | None | 0.64A | 1ya4A-3k6kA:16.8 | 1ya4A-3k6kA:21.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3k9b | LIVERCARBOXYLESTERASE 1 (Homo sapiens) |
PF00135(COesterase) | 6 | ALA A1093GLY A1142SER A1221LEU A1363MET A1364HIS A1468 | NoneWW2 A 193 (-3.4A)WW2 A 193 (-1.4A)WW2 A 193 (-3.8A)NoneNone | 1.04A | 1ya4A-3k9bA:69.0 | 1ya4A-3k9bA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3k9b | LIVERCARBOXYLESTERASE 1 (Homo sapiens) |
PF00135(COesterase) | 9 | ALA A1093PHE A1101GLY A1142GLY A1143SER A1221LEU A1363MET A1364LEU A1388HIS A1468 | NoneNoneWW2 A 193 (-3.4A)WW2 A 193 (-3.4A)WW2 A 193 (-1.4A)WW2 A 193 (-3.8A)NoneNoneNone | 0.38A | 1ya4A-3k9bA:69.0 | 1ya4A-3k9bA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m4a | PUTATIVE TYPE ITOPOISOMERASE (Deinococcusradiodurans) |
PF01028(Topoisom_I) | 5 | ALA A 248GLY A 243LEU A 328LEU A 95LEU A 102 | None | 1.02A | 1ya4A-3m4aA:undetectable | 1ya4A-3m4aA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ne5 | CATION EFFLUX SYSTEMPROTEIN CUSA (Escherichiacoli) |
PF00873(ACR_tran) | 6 | ALA A1013PHE A 461GLY A 395GLY A 394LEU A 338LEU A 39 | None | 1.28A | 1ya4A-3ne5A:undetectable | 1ya4A-3ne5A:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pie | 5'->3'EXORIBONUCLEASE(XRN1) (Kluyveromyceslactis) |
PF03159(XRN_N) | 5 | GLY A 937GLY A 936LEU A1233SER A1234LEU A1231 | None | 0.91A | 1ya4A-3pieA:undetectable | 1ya4A-3pieA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rbl | AROMATIC L-AMINOACID DECARBOXYLASE (Homo sapiens) |
PF00282(Pyridoxal_deC) | 5 | ALA A 185GLY A 203GLY A 202LEU A 156LEU A 157 | None | 0.90A | 1ya4A-3rblA:undetectable | 1ya4A-3rblA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3red | HYDROXYNITRILE LYASE (Prunus mume) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | ALA A 42GLY A 35GLY A 104SER A 107LEU A 201 | NoneFAD A 773 (-3.4A)NoneNoneNone | 0.86A | 1ya4A-3redA:undetectable | 1ya4A-3redA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rgw | MEMBRANE-BOUNDHYDROGENASE (NIFE)LARGE SUBUNIT HOXG (Cupriavidusnecator) |
PF00374(NiFeSe_Hases) | 5 | ALA L 532GLY L 323GLY L 324MET L 409LEU L 327 | None | 1.03A | 1ya4A-3rgwL:undetectable | 1ya4A-3rgwL:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rhg | PUTATIVEPHOPHOTRIESTERASE (Proteusmirabilis) |
PF02126(PTE) | 5 | ALA A 95GLY A 168SER A 226MET A 196LEU A 214 | ZN A 367 ( 4.6A)NoneNoneNoneNone | 1.01A | 1ya4A-3rhgA:undetectable | 1ya4A-3rhgA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slk | POLYKETIDE SYNTHASEEXTENDER MODULE 2 (Saccharopolysporaspinosa) |
PF08240(ADH_N)PF08659(KR)PF13602(ADH_zinc_N_2) | 6 | ALA A 569GLY A 516GLY A 517LEU A 567SER A 566LEU A 554 | NoneNDP A 802 (-3.3A)NoneNoneNoneNone | 1.45A | 1ya4A-3slkA:2.6 | 1ya4A-3slkA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 5 | ALA A 304PHE A 213GLY A 287LEU A 71SER A 70 | None | 1.00A | 1ya4A-3uboA:undetectable | 1ya4A-3uboA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wiq | KOJIBIOSEPHOSPHORYLASE (Caldicellulosiruptorsaccharolyticus) |
PF03632(Glyco_hydro_65m)PF03633(Glyco_hydro_65C)PF03636(Glyco_hydro_65N) | 5 | GLY A 449LEU A 508SER A 506LEU A 512LEU A 529 | None | 1.03A | 1ya4A-3wiqA:undetectable | 1ya4A-3wiqA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wmt | PROBABLE FERULOYLESTERASE B-1 (Aspergillusoryzae) |
PF07519(Tannase) | 5 | GLY A 124GLY A 125SER A 203LEU A 126HIS A 457 | None | 0.85A | 1ya4A-3wmtA:11.8 | 1ya4A-3wmtA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwe | OXIDIZED POLYVINYLALCOHOL HYDROLASE (Pseudomonas sp.VM15C) |
no annotation | 5 | ALA A 181GLY A 175GLY A 170LEU A 168LEU A 313 | None | 1.00A | 1ya4A-3wweA:16.6 | 1ya4A-3wweA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x1l | CMR6 (Archaeoglobusfulgidus) |
PF03787(RAMPs) | 5 | ALA H 320PHE H 148GLY H 141LEU H 317LEU H 316 | NoneNone U I 26 ( 3.2A)NoneNone | 0.93A | 1ya4A-3x1lH:undetectable | 1ya4A-3x1lH:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aq9 | ACETYLCHOLINERECEPTOR GAMMASUBUNIT (Torpedomarmorata) |
PF02931(Neur_chan_LBD)PF02932(Neur_chan_memb) | 5 | PHE E 99SER E 125LEU E 39LEU E 34LEU E 212 | None | 1.04A | 1ya4A-4aq9E:undetectable | 1ya4A-4aq9E:20.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4be9 | STEROL ESTERASE (Ophiostomapiceae) |
PF00135(COesterase) | 5 | GLY A 134GLY A 135SER A 220SER A 309HIS A 465 | PGE A1554 ( 4.7A)1PE A1553 (-3.3A)1PE A1553 (-2.9A)NoneNone | 1.03A | 1ya4A-4be9A:41.2 | 1ya4A-4be9A:32.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4be9 | STEROL ESTERASE (Ophiostomapiceae) |
PF00135(COesterase) | 5 | GLY A 134GLY A 135SER A 220SER A 311HIS A 465 | PGE A1554 ( 4.7A)1PE A1553 (-3.3A)1PE A1553 (-2.9A)NoneNone | 1.00A | 1ya4A-4be9A:41.2 | 1ya4A-4be9A:32.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4duu | PLASMINOGEN (Homo sapiens) |
PF00024(PAN_1)PF00051(Kringle)PF00089(Trypsin) | 5 | ALA A 648GLY A 742GLY A 589LEU A 599LEU A 618 | None | 1.00A | 1ya4A-4duuA:undetectable | 1ya4A-4duuA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gyi | RIO2 KINASE (Chaetomiumthermophilum) |
PF01163(RIO1)PF09202(Rio2_N) | 5 | GLY A 79GLY A 80LEU A 19LEU A 86HIS A 185 | NoneNoneNoneNoneEDO A 403 (-4.1A) | 1.02A | 1ya4A-4gyiA:undetectable | 1ya4A-4gyiA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ha6 | PYRIDOXINE 4-OXIDASE (Mesorhizobiumloti) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | ALA A 33GLY A 26GLY A 98LEU A 216HIS A 506 | NoneFAD A 601 (-3.2A)CME A 102 ( 3.4A)NoneFAD A 601 (-4.6A) | 0.91A | 1ya4A-4ha6A:undetectable | 1ya4A-4ha6A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hjl | NAPHTHALENE1,2-DIOXYGENASESUBUNIT ALPHA (Pseudomonas sp.C18) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 5 | PHE A 224GLY A 251LEU A 307MET A 306LEU A 170 | NoneNone15O A 503 ( 4.6A)NoneNone | 0.97A | 1ya4A-4hjlA:undetectable | 1ya4A-4hjlA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hjl | NAPHTHALENE1,2-DIOXYGENASESUBUNIT ALPHA (Pseudomonas sp.C18) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 5 | PHE A 224SER A 305LEU A 307MET A 306LEU A 170 | NoneNone15O A 503 ( 4.6A)NoneNone | 1.04A | 1ya4A-4hjlA:undetectable | 1ya4A-4hjlA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4n | INTRACELLULARPROTEASE/AMIDASE (Vibrio cholerae) |
no annotation | 6 | ALA A 192GLY A 156GLY A 157LEU A 161LEU A 164MET A 162 | None | 1.18A | 1ya4A-4i4nA:2.4 | 1ya4A-4i4nA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igb | LPXTG CELL WALLSURFACE PROTEIN (Streptococcusgordonii) |
no annotation | 5 | ALA D 201GLY D 307LEU D 215SER D 287LEU D 350 | None | 0.98A | 1ya4A-4igbD:undetectable | 1ya4A-4igbD:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcc | IRON-COMPOUND ABCTRANSPORTER,IRON-COMPOUND-BINDING PROTEIN (Streptococcuspneumoniae) |
PF01497(Peripla_BP_2) | 5 | GLY A 66SER A 308LEU A 161SER A 160LEU A 177 | None | 0.87A | 1ya4A-4jccA:undetectable | 1ya4A-4jccA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jot | ENOYL-COA HYDRATASE,PUTATIVE (Deinococcusradiodurans) |
PF00378(ECH_1) | 5 | GLY A 153GLY A 154LEU A 141SER A 140LEU A 187 | None | 0.90A | 1ya4A-4jotA:2.4 | 1ya4A-4jotA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ktp | GLYCOSIDE HYDROLASEFAMILY 65 CENTRALCATALYTIC ([Bacillus]selenitireducens) |
PF03632(Glyco_hydro_65m)PF03633(Glyco_hydro_65C)PF03636(Glyco_hydro_65N) | 5 | PHE A 332GLY A 318GLY A 321LEU A 73SER A 74 | BGC A 801 (-3.7A)NoneNoneNoneNone | 0.97A | 1ya4A-4ktpA:undetectable | 1ya4A-4ktpA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l4x | AMPHI (Streptomycesnodosus) |
PF08659(KR) | 5 | ALA A 318SER A 309LEU A 307LEU A 348HIS A 304 | NoneNDP A 601 (-2.4A)NoneNoneNone | 0.94A | 1ya4A-4l4xA:2.7 | 1ya4A-4l4xA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nwz | FAD-DEPENDENTPYRIDINENUCLEOTIDE-DISULFIDEOXIDOREDUCTASE (Caldalkalibacillusthermarum) |
PF07992(Pyr_redox_2) | 5 | ALA A 18GLY A 106LEU A 103LEU A 35LEU A 98 | None | 0.88A | 1ya4A-4nwzA:undetectable | 1ya4A-4nwzA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6v | NA(+)-TRANSLOCATINGNADH-QUINONEREDUCTASE SUBUNIT BNA(+)-TRANSLOCATINGNADH-QUINONEREDUCTASE SUBUNIT E (Vibrio cholerae) |
PF02508(Rnf-Nqr)PF03116(NQR2_RnfD_RnfE) | 6 | ALA B 207GLY E 189SER E 192LEU B 202SER B 349LEU B 391 | None | 1.29A | 1ya4A-4p6vB:2.6 | 1ya4A-4p6vB:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4plh | MALATE DEHYDROGENASE (Apicomplexa) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 6 | ALA A 259GLY A 176GLY A 175SER A 302LEU A 261LEU A 291 | None | 1.42A | 1ya4A-4plhA:undetectable | 1ya4A-4plhA:21.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4qww | ACETYLCHOLINESTERASE (Bungarusfasciatus) |
PF00135(COesterase) | 5 | ALA A 234PHE A 300GLY A 207SER A 200LEU A 224 | None | 0.94A | 1ya4A-4qwwA:50.0 | 1ya4A-4qwwA:35.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rgy | ESTERASE (unculturedbacterium FLS12) |
PF00756(Esterase) | 5 | GLY A 128GLY A 130LEU A 134LEU A 47LEU A 102 | None | 1.01A | 1ya4A-4rgyA:15.3 | 1ya4A-4rgyA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rgy | ESTERASE (unculturedbacterium FLS12) |
PF00756(Esterase) | 5 | GLY A 130LEU A 134LEU A 47LEU A 102HIS A 49 | None | 0.98A | 1ya4A-4rgyA:15.3 | 1ya4A-4rgyA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4upe | NICKEL-DEPENDENTHYDROGENASE LARGESUBUNIT (Desulfovibriofructosivorans) |
PF00374(NiFeSe_Hases) | 6 | PHE Q 390GLY Q 423SER Q 420LEU Q 411SER Q 412LEU Q 408 | None | 1.38A | 1ya4A-4upeQ:undetectable | 1ya4A-4upeQ:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4us5 | LUCIFERASE-LIKEMONOOXYGENASE (Streptomycesbottropensis) |
PF00296(Bac_luciferase) | 5 | ALA A 187GLY A 74GLY A 75SER A 173LEU A 137 | None | 0.87A | 1ya4A-4us5A:undetectable | 1ya4A-4us5A:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wfi | CUTINASE (Saccharomonosporaviridis) |
PF03403(PAF-AH_p_II) | 5 | PHE A 106GLY A 178GLY A 179LEU A 183HIS A 254 | None | 1.03A | 1ya4A-4wfiA:14.6 | 1ya4A-4wfiA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypv | EST8 (Parvibaculum) |
PF07859(Abhydrolase_3) | 5 | ALA A 30GLY A 87GLY A 88SER A 159HIS A 283 | None | 0.57A | 1ya4A-4ypvA:19.1 | 1ya4A-4ypvA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ck3 | PUTATIVE SIGNALRECOGNITION PARTICLEPROTEIN (Chaetomiumthermophilum) |
PF09439(SRPRB) | 5 | GLY B 327GLY B 326LEU B 246LEU B 199LEU B 267 | None | 1.03A | 1ya4A-5ck3B:2.4 | 1ya4A-5ck3B:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5djw | ALPHA-GLUCOSIDASE II (Bacteroidesthetaiotaomicron) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF17137(DUF5110) | 5 | GLY A 67GLY A 66SER A 422LEU A 74SER A 73 | None | 0.98A | 1ya4A-5djwA:undetectable | 1ya4A-5djwA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dly | PLANTAZOLICINMETHYLTRANSFERASEBAML (Bacillusvelezensis) |
PF13847(Methyltransf_31) | 5 | GLY A 221GLY A 220LEU A 232MET A 233LEU A 242 | None | 0.99A | 1ya4A-5dlyA:3.0 | 1ya4A-5dlyA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5esr | HALOALKANEDEHALOGENASE (Caulobactervibrioides) |
PF00561(Abhydrolase_1) | 5 | GLY A 125GLY A 126LEU A 119LEU A 132LEU A 234 | None | 0.94A | 1ya4A-5esrA:12.3 | 1ya4A-5esrA:18.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fv4 | CARBOXYLIC ESTERHYDROLASE (Sus scrofa) |
PF00135(COesterase) | 7 | ALA A 76PHE A 84GLY A 125GLY A 126SER A 204MET A 345HIS A 449 | None | 0.59A | 1ya4A-5fv4A:66.5 | 1ya4A-5fv4A:78.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g4g | VCP-LIKE ATPASE (Thermoplasmaacidophilum) |
PF00004(AAA)PF02359(CDC48_N)PF02933(CDC48_2) | 6 | ALA A 520GLY A 470LEU A 517LEU A 472LEU A 516HIS A 648 | None | 1.24A | 1ya4A-5g4gA:undetectable | 1ya4A-5g4gA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hc4 | LIPOLYTIC ENZYME (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | GLY A 108GLY A 109SER A 188LEU A 24HIS A 317 | TRS A 402 (-3.3A)TRS A 402 (-3.4A)TRS A 402 (-2.3A)NoneTRS A 402 (-4.3A) | 0.59A | 1ya4A-5hc4A:19.0 | 1ya4A-5hc4A:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iq0 | ESTERASE (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | ALA A 64GLY A 126GLY A 127SER A 201HIS A 333 | None | 0.65A | 1ya4A-5iq0A:19.5 | 1ya4A-5iq0A:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kt0 | 4-HYDROXY-TETRAHYDRODIPICOLINATEREDUCTASE (Trichormusvariabilis) |
PF01113(DapB_N)PF05173(DapB_C) | 5 | PHE A 173LEU A 303SER A 302LEU A 156LEU A 168 | None | 1.00A | 1ya4A-5kt0A:3.3 | 1ya4A-5kt0A:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lm7 | TRANSCRIPTIONTERMINATION/ANTITERMINATION PROTEIN NUSA (Escherichiacoli) |
PF00575(S1)PF08529(NusA_N)PF13184(KH_5) | 5 | ALA A 234GLY A 268GLY A 267LEU A 168MET A 204 | None | 0.98A | 1ya4A-5lm7A:undetectable | 1ya4A-5lm7A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mwn | TYPE VI SECRETIONPROTEIN (Escherichiacoli) |
PF05936(T6SS_VasE) | 5 | ALA A 286GLY A 273LEU A 305SER A 304LEU A 204 | None | 1.01A | 1ya4A-5mwnA:undetectable | 1ya4A-5mwnA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oj7 | NAD-DEPENDENTPROTEIN DEACYLASE (Xenopustropicalis) |
no annotation | 5 | GLY A 61SER A 65SER A 157LEU A 139HIS A 124 | AR6 A 401 (-3.3A)NoneEDO A 406 (-2.6A)NoneNone | 0.97A | 1ya4A-5oj7A:undetectable | 1ya4A-5oj7A:8.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w40 | POPP2 PROTEIN (Ralstoniasolanacearum) |
PF03421(Acetyltransf_14) | 5 | GLY A 385SER A 390LEU A 324SER A 325LEU A 281 | NoneNoneSCY A 321 ( 4.8A)SCY A 321 ( 3.0A)COA A 502 (-4.5A) | 1.00A | 1ya4A-5w40A:undetectable | 1ya4A-5w40A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w8o | HOMOSERINEO-ACETYLTRANSFERASE (Mycolicibacteriumhassiacum) |
PF00561(Abhydrolase_1) | 6 | GLY A 159GLY A 160LEU A 164LEU A 289LEU A 327HIS A 350 | None | 1.28A | 1ya4A-5w8oA:12.7 | 1ya4A-5w8oA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w8p | HOMOSERINEO-ACETYLTRANSFERASE (Mycobacteroidesabscessus) |
PF00561(Abhydrolase_1) | 6 | GLY A 162GLY A 163LEU A 167LEU A 296LEU A 334HIS A 357 | None | 1.26A | 1ya4A-5w8pA:12.5 | 1ya4A-5w8pA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtc | NADH DEHYDROGENASE[UBIQUINONE]IRON-SULFUR PROTEIN2, MITOCHONDRIALNADH-UBIQUINONEOXIDOREDUCTASE CHAIN2 (Homo sapiens) |
no annotation | 5 | ALA Q 44GLY Q 49LEU i 228SER i 231LEU i 175 | None | 1.01A | 1ya4A-5xtcQ:undetectable | 1ya4A-5xtcQ:6.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xw5 | TYROSINE-PROTEINPHOSPHATASE CDC14 (Saccharomycescerevisiae) |
PF00782(DSPc)PF14671(DSPn) | 5 | ALA A 352GLY A 267SER A 260LEU A 359LEU A 249 | None | 0.95A | 1ya4A-5xw5A:undetectable | 1ya4A-5xw5A:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6at7 | PHENYLALANINEAMMONIA-LYASE (Sorghum bicolor) |
no annotation | 5 | ALA A 267GLY A 348GLY A 300LEU A 354LEU A 22 | None | 0.96A | 1ya4A-6at7A:undetectable | 1ya4A-6at7A:9.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d79 | SULFATE TRANSPORTERCYSZ (Pseudomonasfragi) |
no annotation | 5 | ALA A 229PHE A 236GLY A 209GLY A 210LEU A 214 | None | 1.00A | 1ya4A-6d79A:undetectable | 1ya4A-6d79A:9.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g21 | PROBABLE FERULOYLESTERASE B-2 (Aspergillusoryzae) |
no annotation | 5 | GLY A 90GLY A 91SER A 169LEU A 92HIS A 421 | None | 0.86A | 1ya4A-6g21A:12.5 | 1ya4A-6g21A:10.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6req | PROTEIN(METHYLMALONYL-COAMUTASE) (Propionibacteriumfreudenreichii) |
PF01642(MM_CoA_mutase) | 5 | GLY B 198SER B 135LEU B 195LEU B 137LEU B 154 | None | 0.96A | 1ya4A-6reqB:undetectable | 1ya4A-6reqB:24.19 |