SIMILAR PATTERNS OF AMINO ACIDS FOR 1YA4_A_CTXA11_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5i PLASMINOGEN
ACTIVATOR


(Desmodus
rotundus)
PF00089
(Trypsin)
4 MET A 202
LEU A 210
GLY A 211
LEU A 162
None
0.90A 1ya4A-1a5iA:
undetectable
1ya4A-1a5iA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B)
PF00073
(Rhv)
4 PRO 2  56
LEU 2  91
GLY 2  90
PRO 2 247
None
0.93A 1ya4A-1ev12:
undetectable
1ya4A-1ev12:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE


(Methanocaldococcus
jannaschii)
PF00579
(tRNA-synt_1b)
4 LEU A  69
GLY A 105
LEU A  79
PRO A  37
None
0.77A 1ya4A-1j1uA:
undetectable
1ya4A-1j1uA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0w GLUTATHIONE
SYNTHETASE


(Saccharomyces
cerevisiae)
PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP)
4 LEU A 336
GLY A 337
LYS A 346
LEU A 350
None
0.88A 1ya4A-1m0wA:
undetectable
1ya4A-1m0wA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN CAPSID
PROTEIN


(Enterovirus B)
PF00073
(Rhv)
4 PRO B  56
LEU B  91
GLY B  90
PRO B 247
None
0.94A 1ya4A-1mqtB:
undetectable
1ya4A-1mqtB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens)
PF00023
(Ank)
PF12796
(Ank_2)
4 PRO E 137
LEU E 163
GLY E 161
LEU E 131
None
0.79A 1ya4A-1nfiE:
undetectable
1ya4A-1nfiE:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puc P13SUC1

(Schizosaccharomyces
pombe)
PF01111
(CKS)
4 PRO A  52
LEU A  74
GLY A  75
LEU A  10
None
0.85A 1ya4A-1pucA:
undetectable
1ya4A-1pucA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb3 CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT


(Saccharomyces
cerevisiae)
PF01111
(CKS)
4 PRO A  55
LEU A  77
GLY A  78
LEU A  13
None
0.82A 1ya4A-1qb3A:
undetectable
1ya4A-1qb3A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))


(Homo sapiens)
PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer)
4 PRO P  83
LEU P 140
GLY P 141
LEU P 215
None
0.93A 1ya4A-1svcP:
undetectable
1ya4A-1svcP:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t61 TYPE IV COLLAGEN

(Bos taurus)
PF01413
(C4)
4 MET A 145
LEU A  47
GLY A  48
LEU A 165
None
0.85A 1ya4A-1t61A:
undetectable
1ya4A-1t61A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli)
PF02541
(Ppx-GppA)
4 LEU A 441
GLY A 442
LEU A 486
PRO A 455
None
0.74A 1ya4A-1u6zA:
undetectable
1ya4A-1u6zA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN


(Human
alphaherpesvirus
1)
PF00747
(Viral_DNA_bp)
4 LEU A 672
GLY A 673
LEU A 668
PRO A 247
None
0.92A 1ya4A-1urjA:
undetectable
1ya4A-1urjA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF01039
(Carboxyl_trans)
4 LEU A1860
GLY A1859
LEU A1950
PRO A1835
None
0.95A 1ya4A-1uyvA:
undetectable
1ya4A-1uyvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes)
PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
4 LEU A 180
GLY A 181
LEU A 189
PRO A 238
None
0.86A 1ya4A-1xeuA:
undetectable
1ya4A-1xeuA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR


(Pseudomonas
aeruginosa)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 LEU A 536
GLY A 583
LEU A 538
PRO A  76
LDA  A2002 (-4.9A)
None
LDA  A2001 ( 4.5A)
None
0.94A 1ya4A-1xkwA:
undetectable
1ya4A-1xkwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzw GFP-LIKE
NON-FLUORESCENT
CHROMOPROTEIN


(Heteractis
crispa)
PF01353
(GFP)
4 LEU A   5
GLY A   4
LEU A 111
PRO A  35
None
0.76A 1ya4A-1yzwA:
undetectable
1ya4A-1yzwA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE


(Archaeoglobus
fulgidus)
PF01513
(NAD_kinase)
4 PRO A 169
LEU A  75
GLY A  74
LYS A 244
None
NAP  A3076 (-4.3A)
NAP  A3076 ( 4.9A)
None
0.81A 1ya4A-1z0uA:
2.5
1ya4A-1z0uA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE


(Anopheles
gambiae)
PF00266
(Aminotran_5)
4 PRO A 215
LEU A 207
GLY A 208
LEU A 268
None
0.94A 1ya4A-2ch1A:
undetectable
1ya4A-2ch1A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6e 5'-NUCLEOTIDASE SURE

(Thermus
thermophilus)
PF01975
(SurE)
4 LEU A 119
GLY A 117
LEU A 229
PRO A 158
None
0.82A 1ya4A-2e6eA:
undetectable
1ya4A-2e6eA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1


(Caenorhabditis
elegans)
PF00883
(Peptidase_M17)
4 PRO A 103
LEU A  17
GLY A  16
LEU A  71
None
0.85A 1ya4A-2hb6A:
3.0
1ya4A-2hb6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE


(Methanocaldococcus
jannaschii)
PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7)
4 PRO A 188
LEU A 151
GLY A 153
LEU A 178
None
0.74A 1ya4A-2hmfA:
undetectable
1ya4A-2hmfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY


(Streptococcus
pneumoniae)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 PRO A 303
LEU A 251
GLY A 250
LEU A 339
None
0.85A 1ya4A-2pokA:
2.3
1ya4A-2pokA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29)
PF03175
(DNA_pol_B_2)
4 TRP A  81
GLY A  67
LEU A  74
PRO A 404
None
0.85A 1ya4A-2pyjA:
undetectable
1ya4A-2pyjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN


(Arabidopsis
thaliana)
PF00696
(AA_kinase)
4 PRO A 177
LEU A 134
GLY A 136
LEU A 167
None
0.69A 1ya4A-2rd5A:
undetectable
1ya4A-2rd5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkb SERINE
DEHYDRATASE-LIKE


(Homo sapiens)
PF00291
(PALP)
4 PRO A 166
LEU A 186
GLY A 185
LEU A 169
None
0.94A 1ya4A-2rkbA:
undetectable
1ya4A-2rkbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0f CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 7


(Homo sapiens)
PF07533
(BRK)
4 TRP A2685
LEU A2704
GLY A2706
PRO A2633
None
0.92A 1ya4A-2v0fA:
undetectable
1ya4A-2v0fA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE


(Paraburkholderia
xenovorans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 PRO A  87
GLY A 239
LEU A 256
PRO A 247
None
0.79A 1ya4A-2v7bA:
2.6
1ya4A-2v7bA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x17 PUTATIVE FERRITIN
HOMOLOG


(Pyrococcus
furiosus)
PF00210
(Ferritin)
4 PRO 0  83
LEU 0  36
GLY 0  38
LEU 0 151
None
0.90A 1ya4A-2x170:
undetectable
1ya4A-2x170:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B


(Thermosynechococcus
elongatus)
PF00148
(Oxidored_nitro)
4 PRO B 246
MET B 247
LEU B 188
PRO B 408
None
0.92A 1ya4A-2xdqB:
undetectable
1ya4A-2xdqB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0h PROBABLE PORIN

(Pseudomonas
aeruginosa)
PF03573
(OprD)
4 PRO A 113
LEU A 180
GLY A 198
LEU A 150
None
0.77A 1ya4A-2y0hA:
undetectable
1ya4A-2y0hA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3p METHYLTRANSFERASE

(Geobacter
sulfurreducens)
PF01596
(Methyltransf_3)
4 LEU A 142
GLY A 138
LEU A 155
PRO A  62
None
0.78A 1ya4A-3c3pA:
undetectable
1ya4A-3c3pA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE


(Homo sapiens)
PF00248
(Aldo_ket_red)
4 PRO A 189
LEU A 185
GLY A 184
LYS A 182
None
0.91A 1ya4A-3cavA:
undetectable
1ya4A-3cavA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE


(Bacillus
halodurans)
PF16499
(Melibiase_2)
4 MET A 315
LEU A 276
GLY A 277
LEU A 331
None
0.94A 1ya4A-3cc1A:
undetectable
1ya4A-3cc1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT


(Methanosarcina
barkeri)
PF03063
(Prismane)
4 PRO A 692
LEU A 621
GLY A 617
LEU A 695
None
0.75A 1ya4A-3cf4A:
2.1
1ya4A-3cf4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8p ACETYLTRANSFERASE OF
GNAT FAMILY


(Staphylococcus
aureus)
PF13673
(Acetyltransf_10)
4 TRP A  55
LEU A  99
GLY A  95
LEU A  80
None
None
EDO  A 168 ( 4.4A)
EDO  A 167 (-4.4A)
0.68A 1ya4A-3d8pA:
undetectable
1ya4A-3d8pA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6q PUTATIVE
5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE


(Pseudomonas
aeruginosa)
PF02962
(CHMI)
4 PRO A   2
LEU A  80
GLY A  81
LEU A  29
None
0.83A 1ya4A-3e6qA:
undetectable
1ya4A-3e6qA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epd PROTEIN VP2

(Enterovirus C)
PF00073
(Rhv)
4 PRO 2  56
LEU 2  91
GLY 2  90
PRO 2 254
None
0.92A 1ya4A-3epd2:
undetectable
1ya4A-3epd2:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epf PROTEIN VP2

(Enterovirus C)
PF00073
(Rhv)
4 PRO 2  56
LEU 2  91
GLY 2  90
PRO 2 254
None
0.95A 1ya4A-3epf2:
undetectable
1ya4A-3epf2:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcj PEPTIDE METHIONINE
SULFOXIDE REDUCTASE


(Xanthomonas
campestris)
PF01641
(SelR)
4 LEU A 109
GLY A 110
LEU A 131
PRO A  74
None
0.83A 1ya4A-3hcjA:
undetectable
1ya4A-3hcjA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Geobacter
metallireducens)
PF00155
(Aminotran_1_2)
4 PRO A 112
LEU A 133
GLY A 135
LEU A 160
None
0.81A 1ya4A-3hdoA:
undetectable
1ya4A-3hdoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B


(Sulfolobus
solfataricus)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
4 PRO B 148
LEU B  23
GLY B  22
LEU B 423
None
0.95A 1ya4A-3hkzB:
undetectable
1ya4A-3hkzB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis)
PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3)
4 LEU A 187
GLY A 191
LEU A 203
PRO A 254
None
0.73A 1ya4A-3hvdA:
undetectable
1ya4A-3hvdA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP2

(Enterovirus B)
PF00073
(Rhv)
4 PRO C  47
LEU C  82
GLY C  81
PRO C 238
None
0.91A 1ya4A-3j2jC:
undetectable
1ya4A-3j2jC:
18.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1


(Homo sapiens)
PF00135
(COesterase)
4 PRO A1360
MET A1361
LEU A1368
LEU A1418
None
0.80A 1ya4A-3k9bA:
69.0
1ya4A-3k9bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1


(Homo sapiens)
PF00135
(COesterase)
5 TRP A1357
PRO A1360
LEU A1368
LEU A1418
PRO A1461
None
0.57A 1ya4A-3k9bA:
69.0
1ya4A-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6m RPFF PROTEIN
SENSORY/REGULATORY
PROTEIN RPFC


(Xanthomonas
campestris)
PF00072
(Response_reg)
PF00378
(ECH_1)
4 MET D 530
LEU A 136
GLY A 137
LEU A 194
None
None
EDO  A 902 (-3.6A)
None
0.83A 1ya4A-3m6mD:
3.0
1ya4A-3m6mD:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mso STEROID
DELTA-ISOMERASE


(Pseudomonas
aeruginosa)
PF12680
(SnoaL_2)
4 MET A  56
LEU A  29
GLY A  28
LEU A  33
None
0.81A 1ya4A-3msoA:
undetectable
1ya4A-3msoA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzk PROTEIN TRANSPORT
PROTEIN SEC16


(Saccharomyces
cerevisiae)
PF12931
(Sec16_C)
PF12932
(Sec16)
4 MET B1134
LEU B1128
LYS B1155
LEU B1151
None
0.94A 1ya4A-3mzkB:
undetectable
1ya4A-3mzkB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfd ACYL-COA
DEHYDROGENASE


(Mycolicibacterium
thermoresistibile)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
4 LEU A 107
GLY A 111
LYS A 116
LEU A 120
None
0.91A 1ya4A-3pfdA:
undetectable
1ya4A-3pfdA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
4 LEU A 279
GLY A 278
LYS A 274
LEU A 259
None
0.71A 1ya4A-3qtpA:
undetectable
1ya4A-3qtpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy2 CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT


(Saccharomyces
cerevisiae)
PF01111
(CKS)
4 PRO A  55
LEU A  77
GLY A  78
LEU A  13
None
0.80A 1ya4A-3qy2A:
undetectable
1ya4A-3qy2A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2


(Saccharopolyspora
spinosa)
PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2)
4 TRP A 682
GLY A 599
LYS A 621
LEU A 663
None
NDP  A 802 (-3.7A)
NDP  A 802 (-2.5A)
None
0.91A 1ya4A-3slkA:
2.5
1ya4A-3slkA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis)
PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3)
4 LEU A 187
GLY A 191
LEU A 203
PRO A 254
None
0.69A 1ya4A-3texA:
undetectable
1ya4A-3texA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v30 DNA-BINDING PROTEIN
RFXANK


(Homo sapiens)
PF12796
(Ank_2)
PF13606
(Ank_3)
4 PRO A 150
LEU A 176
GLY A 174
LEU A 144
None
0.94A 1ya4A-3v30A:
undetectable
1ya4A-3v30A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L


(Escherichia
coli)
PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM)
4 PRO A 310
LEU A 329
GLY A 330
LEU A 344
None
0.92A 1ya4A-3v8vA:
undetectable
1ya4A-3v8vA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1


(Toxoplasma
gondii)
PF01150
(GDA1_CD39)
4 MET A 325
LEU A 335
GLY A 334
LEU A 453
None
0.91A 1ya4A-4a5aA:
undetectable
1ya4A-4a5aA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amm DYNE8

(Micromonospora
chersina)
PF00698
(Acyl_transf_1)
4 PRO A 644
LEU A 860
GLY A 856
LEU A 637
None
0.89A 1ya4A-4ammA:
undetectable
1ya4A-4ammA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans)
PF00128
(Alpha-amylase)
4 LEU A 114
GLY A 115
LEU A 547
PRO A 485
None
0.92A 1ya4A-4aysA:
undetectable
1ya4A-4aysA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce5 AT-OMEGATA

(Aspergillus
terreus)
PF01063
(Aminotran_4)
4 PRO A 202
LEU A 187
GLY A 185
LEU A 204
None
0.93A 1ya4A-4ce5A:
undetectable
1ya4A-4ce5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmf AMINOTRANSFERASE

([Nectria]
haematococca)
PF01063
(Aminotran_4)
4 PRO A 201
LEU A 186
GLY A 184
LEU A 203
None
0.93A 1ya4A-4cmfA:
undetectable
1ya4A-4cmfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE


(Pseudomonas sp.
ADP)
PF01425
(Amidase)
4 MET A 386
LEU A 456
GLY A 457
LEU A 297
None
0.86A 1ya4A-4cp8A:
undetectable
1ya4A-4cp8A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1e ALPHA-ACTININ-2

(Homo sapiens)
PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen)
4 LEU A 186
GLY A 183
LEU A 229
PRO A 240
None
MLZ  A 181 ( 4.3A)
None
MLZ  A 239 ( 2.6A)
0.95A 1ya4A-4d1eA:
undetectable
1ya4A-4d1eA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dol AT1G53520

(Arabidopsis
thaliana)
PF02431
(Chalcone)
4 PRO A  30
LEU A 173
GLY A 172
LEU A 155
None
0.90A 1ya4A-4dolA:
undetectable
1ya4A-4dolA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsp PROBABLE PORIN

(Pseudomonas
aeruginosa)
PF03573
(OprD)
4 PRO A 112
LEU A 183
GLY A 201
LEU A 149
None
0.76A 1ya4A-4fspA:
undetectable
1ya4A-4fspA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb3 COAT PROTEIN 2

(Enterovirus B)
PF00073
(Rhv)
4 PRO 2  56
LEU 2  91
GLY 2  90
PRO 2 249
None
0.86A 1ya4A-4gb32:
undetectable
1ya4A-4gb32:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 PRO A 218
LEU A 230
GLY A 228
LEU A 238
None
0.91A 1ya4A-4jn7A:
2.6
1ya4A-4jn7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxz GC1008 HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 PRO H 133
LEU H 196
GLY H 197
LEU H 145
None
0.92A 1ya4A-4kxzH:
undetectable
1ya4A-4kxzH:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldz TRANSCRIPTIONAL
REGULATORY PROTEIN
DESR


(Bacillus
subtilis)
PF00072
(Response_reg)
PF00196
(GerE)
4 MET A  53
LEU A  17
GLY A  18
LEU A 109
None
0.61A 1ya4A-4ldzA:
3.6
1ya4A-4ldzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le1 TRANSCRIPTIONAL
REGULATORY PROTEIN
DESR


(Bacillus
subtilis)
PF00072
(Response_reg)
4 MET A  53
LEU A  17
GLY A  18
LEU A 109
None
0.87A 1ya4A-4le1A:
3.7
1ya4A-4le1A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx1 UNCONVENTIONAL
MYOSIN-VA


(Homo sapiens)
PF01843
(DIL)
4 PRO A1507
LEU A1845
GLY A1846
LEU A1493
None
0.89A 1ya4A-4lx1A:
undetectable
1ya4A-4lx1A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwp UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF02962
(CHMI)
4 PRO E   2
LEU E  80
GLY E  81
LEU E  29
SO4  E 204 (-4.2A)
None
None
None
0.91A 1ya4A-4nwpE:
undetectable
1ya4A-4nwpE:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE


(Geobacillus
stearothermophilus)
PF16499
(Melibiase_2)
4 MET A 329
LEU A 290
GLY A 291
LEU A 345
None
0.95A 1ya4A-4nxkA:
undetectable
1ya4A-4nxkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile)
PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore)
4 PRO A1137
LEU A1166
GLY A1167
PRO A1225
None
0.83A 1ya4A-4r04A:
undetectable
1ya4A-4r04A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN


(Nitratireductor
pacificus)
PF12838
(Fer4_7)
PF13486
(Dehalogenase)
4 LEU A 363
GLY A 360
LEU A  46
PRO A 127
None
0.92A 1ya4A-4rasA:
0.0
1ya4A-4rasA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ric FANCONI-ASSOCIATED
NUCLEASE 1


(Homo sapiens)
PF08774
(VRR_NUC)
4 LEU A 916
GLY A 843
LEU A 870
PRO A 585
None
0.89A 1ya4A-4ricA:
2.6
1ya4A-4ricA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE


(Escherichia
coli)
PF02446
(Glyco_hydro_77)
4 LEU A 621
GLY A 620
LEU A 590
PRO A 533
None
0.85A 1ya4A-4s3pA:
undetectable
1ya4A-4s3pA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tll RECEPTOR SUBUNIT
GLUN2B


(Xenopus laevis)
PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd)
4 PRO B 117
LEU B 119
GLY B 291
LEU B 334
None
0.94A 1ya4A-4tllB:
undetectable
1ya4A-4tllB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN THP1


(Saccharomyces
cerevisiae)
PF01399
(PCI)
4 PRO B 273
MET B 271
LEU B 231
LEU B 330
None
0.86A 1ya4A-4trqB:
undetectable
1ya4A-4trqB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xny HEAVY CHAIN OF
ANTIBODY VRC08C


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 PRO H 126
LEU H 189
GLY H 190
LEU H 138
None
0.96A 1ya4A-4xnyH:
undetectable
1ya4A-4xnyH:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans)
PF01055
(Glyco_hydro_31)
PF17137
(DUF5110)
4 PRO A 633
MET A 634
GLY A 710
LEU A 664
None
EDO  A1004 ( 4.8A)
None
None
0.91A 1ya4A-4xprA:
undetectable
1ya4A-4xprA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH


(Escherichia
coli)
PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4)
4 TRP A  19
LEU A 258
GLY A 257
LEU A 263
None
0.91A 1ya4A-4xywA:
3.2
1ya4A-4xywA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE


(Neurospora
crassa)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
4 PRO A 735
LEU A 751
GLY A 749
LEU A 739
None
0.84A 1ya4A-4ztxA:
undetectable
1ya4A-4ztxA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7s CYSTEINE DESULFURASE

(Thermococcus
onnurineus)
PF00266
(Aminotran_5)
4 PRO A 218
MET A 219
LEU A 277
GLY A 273
LLP  A 216 ( 4.0A)
None
None
None
0.86A 1ya4A-5b7sA:
undetectable
1ya4A-5b7sA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central)
4 LEU A1860
GLY A1859
LEU A1950
PRO A1835
None
0.87A 1ya4A-5cslA:
undetectable
1ya4A-5cslA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e94 ANTIBODY FAB
FRAGMENT HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 PRO B 136
LEU B 199
GLY B 200
LEU B 148
None
0.83A 1ya4A-5e94B:
undetectable
1ya4A-5e94B:
17.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE


(Sus scrofa)
PF00135
(COesterase)
4 TRP A 339
PRO A 342
GLY A 352
LEU A 399
None
0.46A 1ya4A-5fv4A:
66.5
1ya4A-5fv4A:
78.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE


(Sus scrofa)
PF00135
(COesterase)
5 TRP A 339
PRO A 342
LEU A 349
LEU A 399
PRO A 442
None
0.59A 1ya4A-5fv4A:
66.5
1ya4A-5fv4A:
78.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy3 GLUCANASE

(Klebsiella
pneumoniae)
PF01270
(Glyco_hydro_8)
4 TRP A 326
LEU A 324
LEU A  61
PRO A 308
None
0.89A 1ya4A-5gy3A:
undetectable
1ya4A-5gy3A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri)
PF13412
(HTH_24)
PF14520
(HHH_5)
4 LEU A 760
GLY A 759
LYS A 796
LEU A 792
None
0.87A 1ya4A-5hm5A:
undetectable
1ya4A-5hm5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho9 EXTRACELLULAR
ARABINANASE


(Geobacillus
stearothermophilus)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C)
4 PRO A 578
LEU A 565
GLY A 566
LEU A 563
SO4  A 710 (-4.0A)
None
None
None
0.95A 1ya4A-5ho9A:
undetectable
1ya4A-5ho9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE


(Geobacillus
stearothermophilus)
PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C)
4 PRO A 578
LEU A 565
GLY A 566
LEU A 563
None
0.92A 1ya4A-5hp6A:
undetectable
1ya4A-5hp6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdm MAJOR TEGUMENT
PROTEIN


(Human
gammaherpesvirus
4)
PF12818
(Tegument_dsDNA)
4 LEU D 551
GLY D 550
LEU D 466
PRO D 572
None
0.95A 1ya4A-5kdmD:
undetectable
1ya4A-5kdmD:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major)
PF05681
(Fumerase)
PF05683
(Fumerase_C)
4 PRO A 446
LEU A 510
GLY A 511
LEU A 413
None
0.74A 1ya4A-5l2rA:
undetectable
1ya4A-5l2rA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus)
PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG)
4 PRO A1176
GLY A1060
LEU A1184
PRO A1053
None
0.83A 1ya4A-5l56A:
undetectable
1ya4A-5l56A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR


(Homo sapiens)
no annotation 4 PRO A 639
LEU A 880
GLY A 830
LEU A 627
None
0.95A 1ya4A-5u8qA:
undetectable
1ya4A-5u8qA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udm PHAGE-ASSOCIATED
CELL WALL HYDROLASE


(Streptococcus
pyogenes)
no annotation 4 TRP B  48
MET B 184
GLY B  37
LEU B  54
None
0.92A 1ya4A-5udmB:
undetectable
1ya4A-5udmB:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uff RBC36

(Petromyzon
marinus)
no annotation 4 LEU A  85
GLY A  86
LEU A  64
PRO A 113
None
0.90A 1ya4A-5uffA:
undetectable
1ya4A-5uffA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN


(Human
alphaherpesvirus
1)
PF03970
(Herpes_UL37_1)
4 LEU A 113
GLY A 112
LEU A 533
PRO A 227
None
0.80A 1ya4A-5vylA:
undetectable
1ya4A-5vylA:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w1u CARBOXYLIC ESTER
HYDROLASE


(Culex
quinquefasciatus)
PF00135
(COesterase)
4 MET A 529
GLY A 397
LEU A 539
PRO A 350
None
0.77A 1ya4A-5w1uA:
39.2
1ya4A-5w1uA:
30.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN


(Thermus
thermophilus)
no annotation 4 LEU A 455
GLY A 453
LEU A 346
PRO A 431
None
0.96A 1ya4A-5xpgA:
undetectable
1ya4A-5xpgA:
10.78