SIMILAR PATTERNS OF AMINO ACIDS FOR 1YA4_A_CTXA1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		4 MET A 202
LEU A 210
GLY A 211
LEU A 162
 None
 0.90A 1ya4A-1a5iA:
undetectable		 1ya4A-1a5iA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		4 PRO 2  56
LEU 2  91
GLY 2  90
PRO 2 247
 None
 0.93A 1ya4A-1ev12:
undetectable		 1ya4A-1ev12:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		4 LEU A  69
GLY A 105
LEU A  79
PRO A  37
 None
 0.77A 1ya4A-1j1uA:
undetectable		 1ya4A-1j1uA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0w GLUTATHIONE
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 LEU A 336
GLY A 337
LYS A 346
LEU A 350
 None
 0.88A 1ya4A-1m0wA:
undetectable		 1ya4A-1m0wA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		4 PRO B  56
LEU B  91
GLY B  90
PRO B 247
 None
 0.94A 1ya4A-1mqtB:
undetectable		 1ya4A-1mqtB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 PRO E 137
LEU E 163
GLY E 161
LEU E 131
 None
 0.79A 1ya4A-1nfiE:
undetectable		 1ya4A-1nfiE:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puc P13SUC1

(Schizosaccharomyces
pombe) 		PF01111
(CKS) 		4 PRO A  52
LEU A  74
GLY A  75
LEU A  10
 None
 0.85A 1ya4A-1pucA:
undetectable		 1ya4A-1pucA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb3 CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01111
(CKS) 		4 PRO A  55
LEU A  77
GLY A  78
LEU A  13
 None
 0.82A 1ya4A-1qb3A:
undetectable		 1ya4A-1qb3A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svc PROTEIN (NUCLEAR
FACTOR KAPPA-B
(NF-KB))

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 PRO P  83
LEU P 140
GLY P 141
LEU P 215
 None
 0.93A 1ya4A-1svcP:
undetectable		 1ya4A-1svcP:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t61 TYPE IV COLLAGEN

(Bos taurus) 		PF01413
(C4) 		4 MET A 145
LEU A  47
GLY A  48
LEU A 165
 None
 0.85A 1ya4A-1t61A:
undetectable		 1ya4A-1t61A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli) 		PF02541
(Ppx-GppA) 		4 LEU A 441
GLY A 442
LEU A 486
PRO A 455
 None
 0.74A 1ya4A-1u6zA:
undetectable		 1ya4A-1u6zA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		4 LEU A 672
GLY A 673
LEU A 668
PRO A 247
 None
 0.92A 1ya4A-1urjA:
undetectable		 1ya4A-1urjA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		4 LEU A1860
GLY A1859
LEU A1950
PRO A1835
 None
 0.95A 1ya4A-1uyvA:
undetectable		 1ya4A-1uyvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 LEU A 180
GLY A 181
LEU A 189
PRO A 238
 None
 0.86A 1ya4A-1xeuA:
undetectable		 1ya4A-1xeuA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 LEU A 536
GLY A 583
LEU A 538
PRO A  76
 LDA  A2002 (-4.9A)
None
LDA  A2001 ( 4.5A)
None
 0.94A 1ya4A-1xkwA:
undetectable		 1ya4A-1xkwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzw GFP-LIKE
NON-FLUORESCENT
CHROMOPROTEIN

(Heteractis
crispa) 		PF01353
(GFP) 		4 LEU A   5
GLY A   4
LEU A 111
PRO A  35
 None
 0.76A 1ya4A-1yzwA:
undetectable		 1ya4A-1yzwA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 PRO A 169
LEU A  75
GLY A  74
LYS A 244
 None
NAP  A3076 (-4.3A)
NAP  A3076 ( 4.9A)
None
 0.81A 1ya4A-1z0uA:
2.5		 1ya4A-1z0uA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE

(Anopheles
gambiae) 		PF00266
(Aminotran_5) 		4 PRO A 215
LEU A 207
GLY A 208
LEU A 268
 None
 0.94A 1ya4A-2ch1A:
undetectable		 1ya4A-2ch1A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6e 5'-NUCLEOTIDASE SURE

(Thermus
thermophilus) 		PF01975
(SurE) 		4 LEU A 119
GLY A 117
LEU A 229
PRO A 158
 None
 0.82A 1ya4A-2e6eA:
undetectable		 1ya4A-2e6eA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		4 PRO A 103
LEU A  17
GLY A  16
LEU A  71
 None
 0.85A 1ya4A-2hb6A:
3.0		 1ya4A-2hb6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		4 PRO A 188
LEU A 151
GLY A 153
LEU A 178
 None
 0.74A 1ya4A-2hmfA:
undetectable		 1ya4A-2hmfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PRO A 303
LEU A 251
GLY A 250
LEU A 339
 None
 0.85A 1ya4A-2pokA:
2.3		 1ya4A-2pokA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		4 TRP A  81
GLY A  67
LEU A  74
PRO A 404
 None
 0.85A 1ya4A-2pyjA:
undetectable		 1ya4A-2pyjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd5 ACETYLGLUTAMATE
KINASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		4 PRO A 177
LEU A 134
GLY A 136
LEU A 167
 None
 0.69A 1ya4A-2rd5A:
undetectable		 1ya4A-2rd5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkb SERINE
DEHYDRATASE-LIKE

(Homo sapiens) 		PF00291
(PALP) 		4 PRO A 166
LEU A 186
GLY A 185
LEU A 169
 None
 0.94A 1ya4A-2rkbA:
undetectable		 1ya4A-2rkbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0f CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 7

(Homo sapiens) 		PF07533
(BRK) 		4 TRP A2685
LEU A2704
GLY A2706
PRO A2633
 None
 0.92A 1ya4A-2v0fA:
undetectable		 1ya4A-2v0fA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PRO A  87
GLY A 239
LEU A 256
PRO A 247
 None
 0.79A 1ya4A-2v7bA:
2.6		 1ya4A-2v7bA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x17 PUTATIVE FERRITIN
HOMOLOG

(Pyrococcus
furiosus) 		PF00210
(Ferritin) 		4 PRO 0  83
LEU 0  36
GLY 0  38
LEU 0 151
 None
 0.90A 1ya4A-2x170:
undetectable		 1ya4A-2x170:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 PRO B 246
MET B 247
LEU B 188
PRO B 408
 None
 0.92A 1ya4A-2xdqB:
undetectable		 1ya4A-2xdqB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0h PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 PRO A 113
LEU A 180
GLY A 198
LEU A 150
 None
 0.77A 1ya4A-2y0hA:
undetectable		 1ya4A-2y0hA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3p METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF01596
(Methyltransf_3) 		4 LEU A 142
GLY A 138
LEU A 155
PRO A  62
 None
 0.78A 1ya4A-3c3pA:
undetectable		 1ya4A-3c3pA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 PRO A 189
LEU A 185
GLY A 184
LYS A 182
 None
 0.91A 1ya4A-3cavA:
undetectable		 1ya4A-3cavA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		4 MET A 315
LEU A 276
GLY A 277
LEU A 331
 None
 0.94A 1ya4A-3cc1A:
undetectable		 1ya4A-3cc1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 PRO A 692
LEU A 621
GLY A 617
LEU A 695
 None
 0.75A 1ya4A-3cf4A:
2.1		 1ya4A-3cf4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8p ACETYLTRANSFERASE OF
GNAT FAMILY

(Staphylococcus
aureus) 		PF13673
(Acetyltransf_10) 		4 TRP A  55
LEU A  99
GLY A  95
LEU A  80
 None
None
EDO  A 168 ( 4.4A)
EDO  A 167 (-4.4A)
 0.68A 1ya4A-3d8pA:
undetectable		 1ya4A-3d8pA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6q PUTATIVE
5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF02962
(CHMI) 		4 PRO A   2
LEU A  80
GLY A  81
LEU A  29
 None
 0.83A 1ya4A-3e6qA:
undetectable		 1ya4A-3e6qA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epd PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 PRO 2  56
LEU 2  91
GLY 2  90
PRO 2 254
 None
 0.92A 1ya4A-3epd2:
undetectable		 1ya4A-3epd2:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epf PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 PRO 2  56
LEU 2  91
GLY 2  90
PRO 2 254
 None
 0.95A 1ya4A-3epf2:
undetectable		 1ya4A-3epf2:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcj PEPTIDE METHIONINE
SULFOXIDE REDUCTASE

(Xanthomonas
campestris) 		PF01641
(SelR) 		4 LEU A 109
GLY A 110
LEU A 131
PRO A  74
 None
 0.83A 1ya4A-3hcjA:
undetectable		 1ya4A-3hcjA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdo HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Geobacter
metallireducens) 		PF00155
(Aminotran_1_2) 		4 PRO A 112
LEU A 133
GLY A 135
LEU A 160
 None
 0.81A 1ya4A-3hdoA:
undetectable		 1ya4A-3hdoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 PRO B 148
LEU B  23
GLY B  22
LEU B 423
 None
 0.95A 1ya4A-3hkzB:
undetectable		 1ya4A-3hkzB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 LEU A 187
GLY A 191
LEU A 203
PRO A 254
 None
 0.73A 1ya4A-3hvdA:
undetectable		 1ya4A-3hvdA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP2

(Enterovirus B) 		PF00073
(Rhv) 		4 PRO C  47
LEU C  82
GLY C  81
PRO C 238
 None
 0.91A 1ya4A-3j2jC:
undetectable		 1ya4A-3j2jC:
18.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		4 PRO A1360
MET A1361
LEU A1368
LEU A1418
 None
 0.80A 1ya4A-3k9bA:
69.0		 1ya4A-3k9bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		5 TRP A1357
PRO A1360
LEU A1368
LEU A1418
PRO A1461
 None
 0.57A 1ya4A-3k9bA:
69.0		 1ya4A-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6m RPFF PROTEIN
SENSORY/REGULATORY
PROTEIN RPFC

(Xanthomonas
campestris) 		PF00072
(Response_reg)
PF00378
(ECH_1) 		4 MET D 530
LEU A 136
GLY A 137
LEU A 194
 None
None
EDO  A 902 (-3.6A)
None
 0.83A 1ya4A-3m6mD:
3.0		 1ya4A-3m6mD:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mso STEROID
DELTA-ISOMERASE

(Pseudomonas
aeruginosa) 		PF12680
(SnoaL_2) 		4 MET A  56
LEU A  29
GLY A  28
LEU A  33
 None
 0.81A 1ya4A-3msoA:
undetectable		 1ya4A-3msoA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzk PROTEIN TRANSPORT
PROTEIN SEC16

(Saccharomyces
cerevisiae) 		PF12931
(Sec16_C)
PF12932
(Sec16) 		4 MET B1134
LEU B1128
LYS B1155
LEU B1151
 None
 0.94A 1ya4A-3mzkB:
undetectable		 1ya4A-3mzkB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfd ACYL-COA
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A 107
GLY A 111
LYS A 116
LEU A 120
 None
 0.91A 1ya4A-3pfdA:
undetectable		 1ya4A-3pfdA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 279
GLY A 278
LYS A 274
LEU A 259
 None
 0.71A 1ya4A-3qtpA:
undetectable		 1ya4A-3qtpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy2 CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01111
(CKS) 		4 PRO A  55
LEU A  77
GLY A  78
LEU A  13
 None
 0.80A 1ya4A-3qy2A:
undetectable		 1ya4A-3qy2A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 TRP A 682
GLY A 599
LYS A 621
LEU A 663
 None
NDP  A 802 (-3.7A)
NDP  A 802 (-2.5A)
None
 0.91A 1ya4A-3slkA:
2.5		 1ya4A-3slkA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 LEU A 187
GLY A 191
LEU A 203
PRO A 254
 None
 0.69A 1ya4A-3texA:
undetectable		 1ya4A-3texA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v30 DNA-BINDING PROTEIN
RFXANK

(Homo sapiens) 		PF12796
(Ank_2)
PF13606
(Ank_3) 		4 PRO A 150
LEU A 176
GLY A 174
LEU A 144
 None
 0.94A 1ya4A-3v30A:
undetectable		 1ya4A-3v30A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		4 PRO A 310
LEU A 329
GLY A 330
LEU A 344
 None
 0.92A 1ya4A-3v8vA:
undetectable		 1ya4A-3v8vA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1

(Toxoplasma
gondii) 		PF01150
(GDA1_CD39) 		4 MET A 325
LEU A 335
GLY A 334
LEU A 453
 None
 0.91A 1ya4A-4a5aA:
undetectable		 1ya4A-4a5aA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amm DYNE8

(Micromonospora
chersina) 		PF00698
(Acyl_transf_1) 		4 PRO A 644
LEU A 860
GLY A 856
LEU A 637
 None
 0.89A 1ya4A-4ammA:
undetectable		 1ya4A-4ammA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		4 LEU A 114
GLY A 115
LEU A 547
PRO A 485
 None
 0.92A 1ya4A-4aysA:
undetectable		 1ya4A-4aysA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce5 AT-OMEGATA

(Aspergillus
terreus) 		PF01063
(Aminotran_4) 		4 PRO A 202
LEU A 187
GLY A 185
LEU A 204
 None
 0.93A 1ya4A-4ce5A:
undetectable		 1ya4A-4ce5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmf AMINOTRANSFERASE

([Nectria]
haematococca) 		PF01063
(Aminotran_4) 		4 PRO A 201
LEU A 186
GLY A 184
LEU A 203
 None
 0.93A 1ya4A-4cmfA:
undetectable		 1ya4A-4cmfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		4 MET A 386
LEU A 456
GLY A 457
LEU A 297
 None
 0.86A 1ya4A-4cp8A:
undetectable		 1ya4A-4cp8A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1e ALPHA-ACTININ-2

(Homo sapiens) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		4 LEU A 186
GLY A 183
LEU A 229
PRO A 240
 None
MLZ  A 181 ( 4.3A)
None
MLZ  A 239 ( 2.6A)
 0.95A 1ya4A-4d1eA:
undetectable		 1ya4A-4d1eA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dol AT1G53520

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		4 PRO A  30
LEU A 173
GLY A 172
LEU A 155
 None
 0.90A 1ya4A-4dolA:
undetectable		 1ya4A-4dolA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsp PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 PRO A 112
LEU A 183
GLY A 201
LEU A 149
 None
 0.76A 1ya4A-4fspA:
undetectable		 1ya4A-4fspA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb3 COAT PROTEIN 2

(Enterovirus B) 		PF00073
(Rhv) 		4 PRO 2  56
LEU 2  91
GLY 2  90
PRO 2 249
 None
 0.86A 1ya4A-4gb32:
undetectable		 1ya4A-4gb32:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PRO A 218
LEU A 230
GLY A 228
LEU A 238
 None
 0.91A 1ya4A-4jn7A:
2.6		 1ya4A-4jn7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxz GC1008 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO H 133
LEU H 196
GLY H 197
LEU H 145
 None
 0.92A 1ya4A-4kxzH:
undetectable		 1ya4A-4kxzH:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldz TRANSCRIPTIONAL
REGULATORY PROTEIN
DESR

(Bacillus
subtilis) 		PF00072
(Response_reg)
PF00196
(GerE) 		4 MET A  53
LEU A  17
GLY A  18
LEU A 109
 None
 0.61A 1ya4A-4ldzA:
3.6		 1ya4A-4ldzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le1 TRANSCRIPTIONAL
REGULATORY PROTEIN
DESR

(Bacillus
subtilis) 		PF00072
(Response_reg) 		4 MET A  53
LEU A  17
GLY A  18
LEU A 109
 None
 0.87A 1ya4A-4le1A:
3.7		 1ya4A-4le1A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx1 UNCONVENTIONAL
MYOSIN-VA

(Homo sapiens) 		PF01843
(DIL) 		4 PRO A1507
LEU A1845
GLY A1846
LEU A1493
 None
 0.89A 1ya4A-4lx1A:
undetectable		 1ya4A-4lx1A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwp UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF02962
(CHMI) 		4 PRO E   2
LEU E  80
GLY E  81
LEU E  29
 SO4  E 204 (-4.2A)
None
None
None
 0.91A 1ya4A-4nwpE:
undetectable		 1ya4A-4nwpE:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE

(Geobacillus
stearothermophilus) 		PF16499
(Melibiase_2) 		4 MET A 329
LEU A 290
GLY A 291
LEU A 345
 None
 0.95A 1ya4A-4nxkA:
undetectable		 1ya4A-4nxkA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		4 PRO A1137
LEU A1166
GLY A1167
PRO A1225
 None
 0.83A 1ya4A-4r04A:
undetectable		 1ya4A-4r04A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		4 LEU A 363
GLY A 360
LEU A  46
PRO A 127
 None
 0.92A 1ya4A-4rasA:
0.0		 1ya4A-4rasA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ric FANCONI-ASSOCIATED
NUCLEASE 1

(Homo sapiens) 		PF08774
(VRR_NUC) 		4 LEU A 916
GLY A 843
LEU A 870
PRO A 585
 None
 0.89A 1ya4A-4ricA:
2.6		 1ya4A-4ricA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3p 4-ALPHA-GLUCANOTRANS
FERASE

(Escherichia
coli) 		PF02446
(Glyco_hydro_77) 		4 LEU A 621
GLY A 620
LEU A 590
PRO A 533
 None
 0.85A 1ya4A-4s3pA:
undetectable		 1ya4A-4s3pA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tll RECEPTOR SUBUNIT
GLUN2B

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 PRO B 117
LEU B 119
GLY B 291
LEU B 334
 None
 0.94A 1ya4A-4tllB:
undetectable		 1ya4A-4tllB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		4 PRO B 273
MET B 271
LEU B 231
LEU B 330
 None
 0.86A 1ya4A-4trqB:
undetectable		 1ya4A-4trqB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xny HEAVY CHAIN OF
ANTIBODY VRC08C

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO H 126
LEU H 189
GLY H 190
LEU H 138
 None
 0.96A 1ya4A-4xnyH:
undetectable		 1ya4A-4xnyH:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		4 PRO A 633
MET A 634
GLY A 710
LEU A 664
 None
EDO  A1004 ( 4.8A)
None
None
 0.91A 1ya4A-4xprA:
undetectable		 1ya4A-4xprA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyw O-ANTIGEN
BIOSYNTHESIS
GLYCOSYLTRANSFERASE
WBNH

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 TRP A  19
LEU A 258
GLY A 257
LEU A 263
 None
 0.91A 1ya4A-4xywA:
3.2		 1ya4A-4xywA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 PRO A 735
LEU A 751
GLY A 749
LEU A 739
 None
 0.84A 1ya4A-4ztxA:
undetectable		 1ya4A-4ztxA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7s CYSTEINE DESULFURASE

(Thermococcus
onnurineus) 		PF00266
(Aminotran_5) 		4 PRO A 218
MET A 219
LEU A 277
GLY A 273
 LLP  A 216 ( 4.0A)
None
None
None
 0.86A 1ya4A-5b7sA:
undetectable		 1ya4A-5b7sA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 LEU A1860
GLY A1859
LEU A1950
PRO A1835
 None
 0.87A 1ya4A-5cslA:
undetectable		 1ya4A-5cslA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e94 ANTIBODY FAB
FRAGMENT HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO B 136
LEU B 199
GLY B 200
LEU B 148
 None
 0.83A 1ya4A-5e94B:
undetectable		 1ya4A-5e94B:
17.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		4 TRP A 339
PRO A 342
GLY A 352
LEU A 399
 None
 0.46A 1ya4A-5fv4A:
66.5		 1ya4A-5fv4A:
78.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 TRP A 339
PRO A 342
LEU A 349
LEU A 399
PRO A 442
 None
 0.59A 1ya4A-5fv4A:
66.5		 1ya4A-5fv4A:
78.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy3 GLUCANASE

(Klebsiella
pneumoniae) 		PF01270
(Glyco_hydro_8) 		4 TRP A 326
LEU A 324
LEU A  61
PRO A 308
 None
 0.89A 1ya4A-5gy3A:
undetectable		 1ya4A-5gy3A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LEU A 760
GLY A 759
LYS A 796
LEU A 792
 None
 0.87A 1ya4A-5hm5A:
undetectable		 1ya4A-5hm5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho9 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 PRO A 578
LEU A 565
GLY A 566
LEU A 563
 SO4  A 710 (-4.0A)
None
None
None
 0.95A 1ya4A-5ho9A:
undetectable		 1ya4A-5ho9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C) 		4 PRO A 578
LEU A 565
GLY A 566
LEU A 563
 None
 0.92A 1ya4A-5hp6A:
undetectable		 1ya4A-5hp6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdm MAJOR TEGUMENT
PROTEIN

(Human
gammaherpesvirus
4) 		PF12818
(Tegument_dsDNA) 		4 LEU D 551
GLY D 550
LEU D 466
PRO D 572
 None
 0.95A 1ya4A-5kdmD:
undetectable		 1ya4A-5kdmD:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		4 PRO A 446
LEU A 510
GLY A 511
LEU A 413
 None
 0.74A 1ya4A-5l2rA:
undetectable		 1ya4A-5l2rA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 PRO A1176
GLY A1060
LEU A1184
PRO A1053
 None
 0.83A 1ya4A-5l56A:
undetectable		 1ya4A-5l56A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		no annotation 4 PRO A 639
LEU A 880
GLY A 830
LEU A 627
 None
 0.95A 1ya4A-5u8qA:
undetectable		 1ya4A-5u8qA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udm PHAGE-ASSOCIATED
CELL WALL HYDROLASE

(Streptococcus
pyogenes) 		no annotation 4 TRP B  48
MET B 184
GLY B  37
LEU B  54
 None
 0.92A 1ya4A-5udmB:
undetectable		 1ya4A-5udmB:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uff RBC36

(Petromyzon
marinus) 		no annotation 4 LEU A  85
GLY A  86
LEU A  64
PRO A 113
 None
 0.90A 1ya4A-5uffA:
undetectable		 1ya4A-5uffA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN

(Human
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		4 LEU A 113
GLY A 112
LEU A 533
PRO A 227
 None
 0.80A 1ya4A-5vylA:
undetectable		 1ya4A-5vylA:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		4 MET A 529
GLY A 397
LEU A 539
PRO A 350
 None
 0.77A 1ya4A-5w1uA:
39.2		 1ya4A-5w1uA:
30.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 4 LEU A 455
GLY A 453
LEU A 346
PRO A 431
 None
 0.96A 1ya4A-5xpgA:
undetectable		 1ya4A-5xpgA:
10.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 ALA A 237
PHE A 307
GLY A 210
SER A 203
LEU A 227
 None
 1.02A 1ya4A-1b41A:
46.3		 1ya4A-1b41A:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		5 ALA A 237
PHE A 307
GLY A 210
SER A 203
LEU A 227
 None
 0.99A 1ya4A-1c2oA:
45.9		 1ya4A-1c2oA:
36.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		5 GLY A 122
GLY A 123
SER A 209
LEU A 297
HIS A 449
 CLL  A 801 (-4.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
CLL  A 801 (-4.8A)
 1.00A 1ya4A-1cleA:
43.0		 1ya4A-1cleA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 122
GLY A 123
SER A 209
LEU A 297
HIS A 449
 None
 1.01A 1ya4A-1crlA:
40.0		 1ya4A-1crlA:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
SER A 209
LEU A 304
HIS A 449
 None
 0.92A 1ya4A-1crlA:
40.0		 1ya4A-1crlA:
30.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE

(Escherichia
coli) 		PF00378
(ECH_1) 		6 GLY A 109
GLY A 110
LEU A  28
SER A  29
LEU A  85
LEU A  71
 2CP  A 270 ( 3.8A)
2CP  A 270 (-3.4A)
None
None
None
None
 1.35A 1ya4A-1ef9A:
undetectable		 1ya4A-1ef9A:
18.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 ALA A 234
PHE A 300
GLY A 207
SER A 200
LEU A 224
 None
None
None
EMM  A1999 ( 1.4A)
None
 0.95A 1ya4A-1gqrA:
52.5		 1ya4A-1gqrA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		6 GLY A 122
GLY A 123
SER A 209
LEU A 127
LEU A 297
HIS A 449
 None
 1.21A 1ya4A-1gz7A:
40.0		 1ya4A-1gz7A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
SER A 209
LEU A 297
HIS A 449
 None
 0.77A 1ya4A-1gz7A:
40.0		 1ya4A-1gz7A:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		5 GLY A 313
GLY A 312
SER A 397
LEU A 293
SER A 294
 None
 0.91A 1ya4A-1hcuA:
undetectable		 1ya4A-1hcuA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		6 ALA A  10
GLY A  46
GLY A  45
LEU A  12
LEU A  13
LEU A  22
 None
3PY  A 802 (-3.5A)
None
None
None
None
 1.36A 1ya4A-1hl2A:
undetectable		 1ya4A-1hl2A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8m SIGNAL RECOGNITION
54 KDA PROTEIN

(Acidianus
ambivalens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ALA F 263
GLY F 257
GLY F 256
SER F  81
LEU F   7
 None
 0.88A 1ya4A-1j8mF:
undetectable		 1ya4A-1j8mF:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		5 ALA A 185
GLY A 203
GLY A 202
LEU A 156
LEU A 157
 None
 0.89A 1ya4A-1js6A:
2.3		 1ya4A-1js6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA

(Escherichia
coli) 		no annotation 5 ALA A 188
GLY A 152
GLY A 153
LEU A 157
LEU A 160
 None
 0.96A 1ya4A-1onsA:
undetectable		 1ya4A-1onsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgy BETA-LACTAMASE

(Citrobacter
freundii) 		PF00144
(Beta-lactamase) 		6 ALA A 110
GLY A  74
GLY A  75
LEU A  85
LEU A 254
LEU A 106
 None
 1.20A 1ya4A-1rgyA:
undetectable		 1ya4A-1rgyA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		5 ALA A 125
GLY A 147
GLY A 148
LEU A 382
LEU A 142
 None
 0.76A 1ya4A-1xzqA:
undetectable		 1ya4A-1xzqA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		6 ALA A 196
GLY A 211
SER A 182
LEU A 180
MET A 181
LEU A 314
 None
 1.38A 1ya4A-1y9aA:
undetectable		 1ya4A-1y9aA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		5 GLY A 686
GLY A 685
LEU A 805
LEU A 798
LEU A 502
 None
 1.04A 1ya4A-1ygpA:
3.4		 1ya4A-1ygpA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A 323
GLY A 324
LEU A 291
LEU A 175
HIS A 158
 None
None
None
None
NI  A 381 (-3.4A)
 0.99A 1ya4A-1ysjA:
undetectable		 1ya4A-1ysjA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00155
(Aminotran_1_2) 		5 GLY A 231
GLY A 227
LEU A 323
LEU A 331
MET A 330
 None
 1.03A 1ya4A-2ay9A:
undetectable		 1ya4A-2ay9A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		5 GLY A  83
SER A 154
LEU A 210
LEU A 195
HIS A 281
 None
 0.87A 1ya4A-2c7bA:
19.0		 1ya4A-2c7bA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 ALA A 396
GLY A 391
LEU A 325
MET A 326
LEU A 384
 None
 0.99A 1ya4A-2fgeA:
undetectable		 1ya4A-2fgeA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II

(Thermotoga
maritima) 		PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C) 		5 ALA A  24
GLY A 240
GLY A 241
LEU A 277
LEU A 266
 None
 1.02A 1ya4A-2hruA:
undetectable		 1ya4A-2hruA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja9 EXOSOME COMPLEX
EXONUCLEASE RRP40

(Saccharomyces
cerevisiae) 		PF15985
(KH_6) 		5 ALA A 101
GLY A 148
LEU A  97
SER A  96
LEU A  88
 None
 0.97A 1ya4A-2ja9A:
undetectable		 1ya4A-2ja9A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jug TUBC PROTEIN

(Archangium
disciforme) 		no annotation 5 GLY A  46
GLY A  47
LEU A  21
LEU A  55
HIS A  50
 None
 1.02A 1ya4A-2jugA:
undetectable		 1ya4A-2jugA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mxz L-ALANYL-D-GLUTAMATE
PEPTIDASE

(Escherichia
virus T5) 		PF13539
(Peptidase_M15_4) 		5 ALA A  71
PHE A  74
GLY A 132
GLY A 131
LEU A 108
 None
 0.98A 1ya4A-2mxzA:
undetectable		 1ya4A-2mxzA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		5 GLY A  92
GLY A  93
SER A 169
LEU A  22
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
 0.82A 1ya4A-2o7rA:
18.4		 1ya4A-2o7rA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 ALA A 286
GLY A 280
GLY A 279
LEU A  46
LEU A  75
 None
 0.83A 1ya4A-2p2mA:
3.0		 1ya4A-2p2mA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7n PATHOGENICITY ISLAND
1 EFFECTOR PROTEIN

(Chromobacterium
violaceum) 		PF06511
(IpaD) 		5 ALA A 153
GLY A 161
LEU A 374
SER A 373
LEU A 378
 None
 1.01A 1ya4A-2p7nA:
undetectable		 1ya4A-2p7nA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus) 		PF04960
(Glutaminase) 		5 ALA A 258
GLY A 277
LEU A 296
SER A 300
LEU A 295
 None
 1.01A 1ya4A-2pbyA:
undetectable		 1ya4A-2pbyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkb SERINE
DEHYDRATASE-LIKE

(Homo sapiens) 		PF00291
(PALP) 		5 ALA A 172
GLY A 176
GLY A 175
LEU A 229
LEU A 219
 PLP  A 400 ( 4.8A)
PLP  A 400 (-2.9A)
PLP  A 400 (-3.4A)
K  A 401 (-4.6A)
None
 1.00A 1ya4A-2rkbA:
undetectable		 1ya4A-2rkbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uun C-PHYCOCYANIN

(Leptolyngbya
sp.) 		PF00502
(Phycobilisome) 		5 ALA B 137
GLY B 132
GLY B 130
SER B  53
LEU B  59
 None
 0.94A 1ya4A-2uunB:
undetectable		 1ya4A-2uunB:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqp POLYSIALIC ACID
CAPSULE BIOSYNTHESIS
PROTEIN SIAC

(Neisseria
meningitidis) 		PF03102
(NeuB)
PF08666
(SAF) 		5 ALA A  37
GLY A  27
LEU A  88
LEU A 120
HIS A  57
 None
 0.94A 1ya4A-2wqpA:
undetectable		 1ya4A-2wqpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Thermus
thermophilus) 		PF01063
(Aminotran_4) 		5 ALA A  76
GLY A  32
GLY A  33
LEU A  79
LEU A  70
 None
 0.97A 1ya4A-2zgiA:
undetectable		 1ya4A-2zgiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 ALA A 256
GLY A 368
GLY A 369
LEU A 133
LEU A 128
 None
 1.03A 1ya4A-3abbA:
undetectable		 1ya4A-3abbA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis) 		PF13460
(NAD_binding_10) 		5 ALA A 129
GLY A  75
GLY A  74
SER A 105
LEU A 153
 None
 0.89A 1ya4A-3dqpA:
3.4		 1ya4A-3dqpA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A  42
GLY A  35
GLY A 104
SER A 107
LEU A 201
 None
FAD  A 522 (-3.3A)
None
None
None
 0.85A 1ya4A-3gdnA:
undetectable		 1ya4A-3gdnA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN

(Ralstonia
solanacearum) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 ALA A 242
PHE A 203
GLY A 257
LEU A 236
LEU A 226
 None
 1.01A 1ya4A-3ghyA:
undetectable		 1ya4A-3ghyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN

(Ralstonia
solanacearum) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 PHE A 203
GLY A 257
LEU A 236
MET A 211
LEU A 226
 None
 0.83A 1ya4A-3ghyA:
undetectable		 1ya4A-3ghyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A  89
GLY A  90
SER A 157
LEU A 192
HIS A 281
 None
 0.64A 1ya4A-3k6kA:
16.8		 1ya4A-3k6kA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		6 ALA A1093
GLY A1142
SER A1221
LEU A1363
MET A1364
HIS A1468
 None
WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
WW2  A 193 (-3.8A)
None
None
 1.04A 1ya4A-3k9bA:
69.0		 1ya4A-3k9bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		9 ALA A1093
PHE A1101
GLY A1142
GLY A1143
SER A1221
LEU A1363
MET A1364
LEU A1388
HIS A1468
 None
None
WW2  A 193 (-3.4A)
WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
WW2  A 193 (-3.8A)
None
None
None
 0.38A 1ya4A-3k9bA:
69.0		 1ya4A-3k9bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4a PUTATIVE TYPE I
TOPOISOMERASE

(Deinococcus
radiodurans) 		PF01028
(Topoisom_I) 		5 ALA A 248
GLY A 243
LEU A 328
LEU A  95
LEU A 102
 None
 1.02A 1ya4A-3m4aA:
undetectable		 1ya4A-3m4aA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		6 ALA A1013
PHE A 461
GLY A 395
GLY A 394
LEU A 338
LEU A  39
 None
 1.28A 1ya4A-3ne5A:
undetectable		 1ya4A-3ne5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		5 GLY A 937
GLY A 936
LEU A1233
SER A1234
LEU A1231
 None
 0.91A 1ya4A-3pieA:
undetectable		 1ya4A-3pieA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 ALA A 185
GLY A 203
GLY A 202
LEU A 156
LEU A 157
 None
 0.90A 1ya4A-3rblA:
undetectable		 1ya4A-3rblA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A  42
GLY A  35
GLY A 104
SER A 107
LEU A 201
 None
FAD  A 773 (-3.4A)
None
None
None
 0.86A 1ya4A-3redA:
undetectable		 1ya4A-3redA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		5 ALA L 532
GLY L 323
GLY L 324
MET L 409
LEU L 327
 None
 1.03A 1ya4A-3rgwL:
undetectable		 1ya4A-3rgwL:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		5 ALA A  95
GLY A 168
SER A 226
MET A 196
LEU A 214
 ZN  A 367 ( 4.6A)
None
None
None
None
 1.01A 1ya4A-3rhgA:
undetectable		 1ya4A-3rhgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		6 ALA A 569
GLY A 516
GLY A 517
LEU A 567
SER A 566
LEU A 554
 None
NDP  A 802 (-3.3A)
None
None
None
None
 1.45A 1ya4A-3slkA:
2.6		 1ya4A-3slkA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		5 ALA A 304
PHE A 213
GLY A 287
LEU A  71
SER A  70
 None
 1.00A 1ya4A-3uboA:
undetectable		 1ya4A-3uboA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 GLY A 449
LEU A 508
SER A 506
LEU A 512
LEU A 529
 None
 1.03A 1ya4A-3wiqA:
undetectable		 1ya4A-3wiqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		5 GLY A 124
GLY A 125
SER A 203
LEU A 126
HIS A 457
 None
 0.85A 1ya4A-3wmtA:
11.8		 1ya4A-3wmtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Pseudomonas sp.
VM15C) 		no annotation 5 ALA A 181
GLY A 175
GLY A 170
LEU A 168
LEU A 313
 None
 1.00A 1ya4A-3wweA:
16.6		 1ya4A-3wweA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR6

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		5 ALA H 320
PHE H 148
GLY H 141
LEU H 317
LEU H 316
 None
None
U  I  26 ( 3.2A)
None
None
 0.93A 1ya4A-3x1lH:
undetectable		 1ya4A-3x1lH:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 PHE E  99
SER E 125
LEU E  39
LEU E  34
LEU E 212
 None
 1.04A 1ya4A-4aq9E:
undetectable		 1ya4A-4aq9E:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 134
GLY A 135
SER A 220
SER A 309
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 1.03A 1ya4A-4be9A:
41.2		 1ya4A-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 GLY A 134
GLY A 135
SER A 220
SER A 311
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 1.00A 1ya4A-4be9A:
41.2		 1ya4A-4be9A:
32.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		5 ALA A 648
GLY A 742
GLY A 589
LEU A 599
LEU A 618
 None
 1.00A 1ya4A-4duuA:
undetectable		 1ya4A-4duuA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyi RIO2 KINASE

(Chaetomium
thermophilum) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		5 GLY A  79
GLY A  80
LEU A  19
LEU A  86
HIS A 185
 None
None
None
None
EDO  A 403 (-4.1A)
 1.02A 1ya4A-4gyiA:
undetectable		 1ya4A-4gyiA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha6 PYRIDOXINE 4-OXIDASE

(Mesorhizobium
loti) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A  33
GLY A  26
GLY A  98
LEU A 216
HIS A 506
 None
FAD  A 601 (-3.2A)
CME  A 102 ( 3.4A)
None
FAD  A 601 (-4.6A)
 0.91A 1ya4A-4ha6A:
undetectable		 1ya4A-4ha6A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 PHE A 224
GLY A 251
LEU A 307
MET A 306
LEU A 170
 None
None
15O  A 503 ( 4.6A)
None
None
 0.97A 1ya4A-4hjlA:
undetectable		 1ya4A-4hjlA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 PHE A 224
SER A 305
LEU A 307
MET A 306
LEU A 170
 None
None
15O  A 503 ( 4.6A)
None
None
 1.04A 1ya4A-4hjlA:
undetectable		 1ya4A-4hjlA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4n INTRACELLULAR
PROTEASE/AMIDASE

(Vibrio cholerae) 		no annotation 6 ALA A 192
GLY A 156
GLY A 157
LEU A 161
LEU A 164
MET A 162
 None
 1.18A 1ya4A-4i4nA:
2.4		 1ya4A-4i4nA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igb LPXTG CELL WALL
SURFACE PROTEIN

(Streptococcus
gordonii) 		no annotation 5 ALA D 201
GLY D 307
LEU D 215
SER D 287
LEU D 350
 None
 0.98A 1ya4A-4igbD:
undetectable		 1ya4A-4igbD:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		5 GLY A  66
SER A 308
LEU A 161
SER A 160
LEU A 177
 None
 0.87A 1ya4A-4jccA:
undetectable		 1ya4A-4jccA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jot ENOYL-COA HYDRATASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF00378
(ECH_1) 		5 GLY A 153
GLY A 154
LEU A 141
SER A 140
LEU A 187
 None
 0.90A 1ya4A-4jotA:
2.4		 1ya4A-4jotA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 PHE A 332
GLY A 318
GLY A 321
LEU A  73
SER A  74
 BGC  A 801 (-3.7A)
None
None
None
None
 0.97A 1ya4A-4ktpA:
undetectable		 1ya4A-4ktpA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus) 		PF08659
(KR) 		5 ALA A 318
SER A 309
LEU A 307
LEU A 348
HIS A 304
 None
NDP  A 601 (-2.4A)
None
None
None
 0.94A 1ya4A-4l4xA:
2.7		 1ya4A-4l4xA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Caldalkalibacillus
thermarum) 		PF07992
(Pyr_redox_2) 		5 ALA A  18
GLY A 106
LEU A 103
LEU A  35
LEU A  98
 None
 0.88A 1ya4A-4nwzA:
undetectable		 1ya4A-4nwzA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio cholerae) 		PF02508
(Rnf-Nqr)
PF03116
(NQR2_RnfD_RnfE) 		6 ALA B 207
GLY E 189
SER E 192
LEU B 202
SER B 349
LEU B 391
 None
 1.29A 1ya4A-4p6vB:
2.6		 1ya4A-4p6vB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plh MALATE DEHYDROGENASE

(Apicomplexa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		6 ALA A 259
GLY A 176
GLY A 175
SER A 302
LEU A 261
LEU A 291
 None
 1.42A 1ya4A-4plhA:
undetectable		 1ya4A-4plhA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		5 ALA A 234
PHE A 300
GLY A 207
SER A 200
LEU A 224
 None
 0.94A 1ya4A-4qwwA:
50.0		 1ya4A-4qwwA:
35.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		5 GLY A 128
GLY A 130
LEU A 134
LEU A  47
LEU A 102
 None
 1.01A 1ya4A-4rgyA:
15.3		 1ya4A-4rgyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		5 GLY A 130
LEU A 134
LEU A  47
LEU A 102
HIS A  49
 None
 0.98A 1ya4A-4rgyA:
15.3		 1ya4A-4rgyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		6 PHE Q 390
GLY Q 423
SER Q 420
LEU Q 411
SER Q 412
LEU Q 408
 None
 1.38A 1ya4A-4upeQ:
undetectable		 1ya4A-4upeQ:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		5 ALA A 187
GLY A  74
GLY A  75
SER A 173
LEU A 137
 None
 0.87A 1ya4A-4us5A:
undetectable		 1ya4A-4us5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfi CUTINASE

(Saccharomonospora
viridis) 		PF03403
(PAF-AH_p_II) 		5 PHE A 106
GLY A 178
GLY A 179
LEU A 183
HIS A 254
 None
 1.03A 1ya4A-4wfiA:
14.6		 1ya4A-4wfiA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		5 ALA A  30
GLY A  87
GLY A  88
SER A 159
HIS A 283
 None
 0.57A 1ya4A-4ypvA:
19.1		 1ya4A-4ypvA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN

(Chaetomium
thermophilum) 		PF09439
(SRPRB) 		5 GLY B 327
GLY B 326
LEU B 246
LEU B 199
LEU B 267
 None
 1.03A 1ya4A-5ck3B:
2.4		 1ya4A-5ck3B:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 GLY A  67
GLY A  66
SER A 422
LEU A  74
SER A  73
 None
 0.98A 1ya4A-5djwA:
undetectable		 1ya4A-5djwA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML

(Bacillus
velezensis) 		PF13847
(Methyltransf_31) 		5 GLY A 221
GLY A 220
LEU A 232
MET A 233
LEU A 242
 None
 0.99A 1ya4A-5dlyA:
3.0		 1ya4A-5dlyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esr HALOALKANE
DEHALOGENASE

(Caulobacter
vibrioides) 		PF00561
(Abhydrolase_1) 		5 GLY A 125
GLY A 126
LEU A 119
LEU A 132
LEU A 234
 None
 0.94A 1ya4A-5esrA:
12.3		 1ya4A-5esrA:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		7 ALA A  76
PHE A  84
GLY A 125
GLY A 126
SER A 204
MET A 345
HIS A 449
 None
 0.59A 1ya4A-5fv4A:
66.5		 1ya4A-5fv4A:
78.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4g VCP-LIKE ATPASE

(Thermoplasma
acidophilum) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		6 ALA A 520
GLY A 470
LEU A 517
LEU A 472
LEU A 516
HIS A 648
 None
 1.24A 1ya4A-5g4gA:
undetectable		 1ya4A-5g4gA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A 108
GLY A 109
SER A 188
LEU A  24
HIS A 317
 TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
 0.59A 1ya4A-5hc4A:
19.0		 1ya4A-5hc4A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 ALA A  64
GLY A 126
GLY A 127
SER A 201
HIS A 333
 None
 0.65A 1ya4A-5iq0A:
19.5		 1ya4A-5iq0A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kt0 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Trichormus
variabilis) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 PHE A 173
LEU A 303
SER A 302
LEU A 156
LEU A 168
 None
 1.00A 1ya4A-5kt0A:
3.3		 1ya4A-5kt0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA

(Escherichia
coli) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		5 ALA A 234
GLY A 268
GLY A 267
LEU A 168
MET A 204
 None
 0.98A 1ya4A-5lm7A:
undetectable		 1ya4A-5lm7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwn TYPE VI SECRETION
PROTEIN

(Escherichia
coli) 		PF05936
(T6SS_VasE) 		5 ALA A 286
GLY A 273
LEU A 305
SER A 304
LEU A 204
 None
 1.01A 1ya4A-5mwnA:
undetectable		 1ya4A-5mwnA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE

(Xenopus
tropicalis) 		no annotation 5 GLY A  61
SER A  65
SER A 157
LEU A 139
HIS A 124
 AR6  A 401 (-3.3A)
None
EDO  A 406 (-2.6A)
None
None
 0.97A 1ya4A-5oj7A:
undetectable		 1ya4A-5oj7A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w40 POPP2 PROTEIN

(Ralstonia
solanacearum) 		PF03421
(Acetyltransf_14) 		5 GLY A 385
SER A 390
LEU A 324
SER A 325
LEU A 281
 None
None
SCY  A 321 ( 4.8A)
SCY  A 321 ( 3.0A)
COA  A 502 (-4.5A)
 1.00A 1ya4A-5w40A:
undetectable		 1ya4A-5w40A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8o HOMOSERINE
O-ACETYLTRANSFERASE

(Mycolicibacterium
hassiacum) 		PF00561
(Abhydrolase_1) 		6 GLY A 159
GLY A 160
LEU A 164
LEU A 289
LEU A 327
HIS A 350
 None
 1.28A 1ya4A-5w8oA:
12.7		 1ya4A-5w8oA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8p HOMOSERINE
O-ACETYLTRANSFERASE

(Mycobacteroides
abscessus) 		PF00561
(Abhydrolase_1) 		6 GLY A 162
GLY A 163
LEU A 167
LEU A 296
LEU A 334
HIS A 357
 None
 1.26A 1ya4A-5w8pA:
12.5		 1ya4A-5w8pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Homo sapiens) 		no annotation 5 ALA Q  44
GLY Q  49
LEU i 228
SER i 231
LEU i 175
 None
 1.01A 1ya4A-5xtcQ:
undetectable		 1ya4A-5xtcQ:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14

(Saccharomyces
cerevisiae) 		PF00782
(DSPc)
PF14671
(DSPn) 		5 ALA A 352
GLY A 267
SER A 260
LEU A 359
LEU A 249
 None
 0.95A 1ya4A-5xw5A:
undetectable		 1ya4A-5xw5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 5 ALA A 267
GLY A 348
GLY A 300
LEU A 354
LEU A  22
 None
 0.96A 1ya4A-6at7A:
undetectable		 1ya4A-6at7A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d79 SULFATE TRANSPORTER
CYSZ

(Pseudomonas
fragi) 		no annotation 5 ALA A 229
PHE A 236
GLY A 209
GLY A 210
LEU A 214
 None
 1.00A 1ya4A-6d79A:
undetectable		 1ya4A-6d79A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 5 GLY A  90
GLY A  91
SER A 169
LEU A  92
HIS A 421
 None
 0.86A 1ya4A-6g21A:
12.5		 1ya4A-6g21A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		5 GLY B 198
SER B 135
LEU B 195
LEU B 137
LEU B 154
 None
 0.96A 1ya4A-6reqB:
undetectable		 1ya4A-6reqB:
24.19