SIMILAR PATTERNS OF AMINO ACIDS FOR 1YA3_C_STRC3001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 LEU A  50
LEU A  36
LEU A 150
ALA A 155
THR A 182
 None
 1.16A 1ya3C-1dppA:
undetectable		 1ya3C-1dppA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		5 LEU A 244
LEU A 241
LEU A 238
ALA A 237
LEU A 419
 None
 1.16A 1ya3C-1l5aA:
undetectable		 1ya3C-1l5aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG
SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF09201
(SRX)
PF09439
(SRPRB) 		5 LEU B  73
LEU B  55
LEU B  54
ARG B 237
THR A   9
 None
 1.16A 1ya3C-1nrjB:
undetectable		 1ya3C-1nrjB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 349
ALA A 350
ARG A 394
MET A 421
 EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 ( 3.7A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
 0.68A 1ya3C-1pcgA:
25.8		 1ya3C-1pcgA:
29.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qx8 REGULATORY PROTEIN
ROP

(Escherichia
coli) 		PF01815
(Rop) 		5 LEU A  23
LEU A  26
ASN A  27
LEU A  29
ALA A  30
 None
 0.47A 1ya3C-1qx8A:
undetectable		 1ya3C-1qx8A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		5 LEU A 131
LEU A 134
ASN A 135
LEU A 137
ALA A 138
 None
 0.78A 1ya3C-1twdA:
undetectable		 1ya3C-1twdA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE

(Bacillus
anthracis) 		PF00809
(Pterin_bind) 		5 LEU A 203
LEU A 206
ASN A 207
LEU A 209
LEU A 214
 None
None
None
None
HH2  A 282 ( 4.9A)
 1.14A 1ya3C-1twwA:
undetectable		 1ya3C-1twwA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhh SONIC HEDGEHOG

(Mus musculus) 		PF01085
(HH_signal) 		5 LEU A 107
ASN A 108
LEU A 110
ALA A 111
MET A  99
 None
 1.14A 1ya3C-1vhhA:
undetectable		 1ya3C-1vhhA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		5 LEU A 279
LEU A 282
ALA A 283
LEU A 469
THR A 412
 None
 0.91A 1ya3C-1w27A:
undetectable		 1ya3C-1w27A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 LEU A 357
LEU A 360
LEU A 363
ALA A 364
LEU A 400
 None
 0.79A 1ya3C-1y4uA:
undetectable		 1ya3C-1y4uA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yo7 REGULATORY PROTEIN
ROP

(Escherichia
coli) 		PF01815
(Rop) 		5 LEU A 111
LEU A 114
ASN A 115
LEU A 117
ALA A 118
 None
 0.90A 1ya3C-1yo7A:
undetectable		 1ya3C-1yo7A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		5 LEU A 183
LEU A 186
LEU A 156
ALA A 157
THR A 162
 None
 1.11A 1ya3C-2a14A:
undetectable		 1ya3C-2a14A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II

(Deinococcus
radiodurans) 		PF00579
(tRNA-synt_1b) 		5 LEU A  37
LEU A  40
ALA A  41
GLN A  45
LEU A 264
 None
 0.85A 1ya3C-2a4mA:
undetectable		 1ya3C-2a4mA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 701
ASN A 705
GLN A 711
MET A 742
ARG A 752
MET A 780
LEU A 873
 None
BHM  A   1 (-3.6A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-4.4A)
 0.96A 1ya3C-2ax9A:
34.8		 1ya3C-2ax9A:
51.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 701
LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 742
ARG A 752
MET A 780
 None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
 0.89A 1ya3C-2ax9A:
34.8		 1ya3C-2ax9A:
51.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b42 XYLANASE INHIBITOR-I

(Triticum
aestivum) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 LEU A  34
LEU A 148
ALA A 149
GLN A 153
LEU A  26
 None
 1.11A 1ya3C-2b42A:
undetectable		 1ya3C-2b42A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bku IMPORTIN BETA-1
SUBUNIT

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU B 199
LEU B 202
ASN B 203
LEU B 205
ALA B 206
 None
 0.62A 1ya3C-2bkuB:
undetectable		 1ya3C-2bkuB:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4p HYPOTHETICAL PROTEIN
TTHA1254

(Thermus
thermophilus) 		PF09390
(DUF1999) 		5 LEU A  11
LEU A  14
ASN A  15
LEU A  17
ALA A  18
 None
 0.97A 1ya3C-2d4pA:
undetectable		 1ya3C-2d4pA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1d TRANSALDOLASE

(Mus musculus) 		PF00923
(TAL_FSA) 		5 LEU A 125
LEU A 128
ALA A 132
LEU A  87
THR A 105
 None
 1.08A 1ya3C-2e1dA:
undetectable		 1ya3C-2e1dA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef0 ORNITHINE
CARBAMOYLTRANSFERASE

(Thermus
thermophilus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  23
LEU A  26
LEU A  29
ALA A  30
LEU A 136
 None
 0.95A 1ya3C-2ef0A:
undetectable		 1ya3C-2ef0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 254
LEU A 251
LEU A 248
GLN A 244
LEU A 206
 None
 1.03A 1ya3C-2f9qA:
undetectable		 1ya3C-2f9qA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 265
LEU A 268
LEU A 271
ALA A 272
MET A 306
ARG A 316
 None
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
 0.54A 1ya3C-2gpvA:
25.0		 1ya3C-2gpvA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq0 CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90) 		5 LEU A 357
LEU A 360
LEU A 363
ALA A 364
LEU A 400
 None
 0.75A 1ya3C-2gq0A:
undetectable		 1ya3C-2gq0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz6 N-ACETYL-D-GLUCOSAMI
NE 2-EPIMERASE

(Anabaena sp.
CH1) 		PF07221
(GlcNAc_2-epim) 		5 LEU A 307
LEU A 310
LEU A 313
ALA A 314
LEU A  11
 None
 0.89A 1ya3C-2gz6A:
undetectable		 1ya3C-2gz6A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibg PROTEIN HEDGEHOG

(Drosophila
melanogaster) 		PF01085
(HH_signal) 		5 LEU E 166
ASN E 167
LEU E 169
ALA E 170
MET E 158
 None
 1.06A 1ya3C-2ibgE:
undetectable		 1ya3C-2ibgE:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 LEU A 357
LEU A 360
LEU A 363
ALA A 364
LEU A 400
 None
 0.77A 1ya3C-2iopA:
undetectable		 1ya3C-2iopA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5e UNCHARACTERIZED
PROTEIN

(Methanocaldococcus
jannaschii) 		PF08984
(DUF1858) 		5 LEU A  58
LEU A  61
ASN A  62
LEU A  64
ALA A  65
 None
 0.85A 1ya3C-2k5eA:
undetectable		 1ya3C-2k5eA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kko POSSIBLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(POSSIBLY
ARSR-FAMILY)

(Mycobacterium
bovis) 		PF12840
(HTH_20) 		5 LEU A  28
LEU A  31
LEU A  34
ALA A  35
LEU A  89
 None
 1.10A 1ya3C-2kkoA:
undetectable		 1ya3C-2kkoA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0x 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00275
(EPSP_synthase) 		5 LEU A 280
LEU A 277
LEU A 274
ALA A 275
LEU A 306
 None
 1.16A 1ya3C-2o0xA:
undetectable		 1ya3C-2o0xA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o42 M11L PROTEIN

(Myxoma virus) 		PF11099
(M11L) 		5 LEU A  81
LEU A  84
LEU A  87
ALA A  88
LEU A  27
 None
 1.13A 1ya3C-2o42A:
undetectable		 1ya3C-2o42A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 349
ALA A 350
ARG A 394
MET A 421
 EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.61A 1ya3C-2ocfA:
27.2		 1ya3C-2ocfA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263

(Thermus
thermophilus) 		PF13429
(TPR_15)
PF14559
(TPR_19) 		5 LEU A  66
LEU A  69
ALA A  70
GLN A  73
THR A  93
 None
 1.05A 1ya3C-2pl2A:
undetectable		 1ya3C-2pl2A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		5 LEU A 144
LEU A 141
LEU A 138
ALA A 137
THR A 330
 None
 0.97A 1ya3C-2puzA:
undetectable		 1ya3C-2puzA:
21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		12 LEU A  29
LEU A  32
ASN A  33
LEU A  35
ALA A  36
GLN A  39
MET A  70
ARG A  80
MET A 108
LEU A 201
CYH A 205
THR A 208
 1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
1CA  A 247 ( 4.2A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
 0.56A 1ya3C-2q3yA:
36.9		 1ya3C-2q3yA:
72.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgh DIAMINOPIMELATE
DECARBOXYLASE

(Helicobacter
pylori) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A  51
LEU A  54
LEU A  57
ALA A  58
LEU A  76
 None
 0.88A 1ya3C-2qghA:
undetectable		 1ya3C-2qghA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmx PREPHENATE
DEHYDRATASE

(Chlorobaculum
tepidum) 		PF00800
(PDT) 		5 LEU A 262
ASN A 261
LEU A 259
ALA A 258
LEU A 215
 None
 0.97A 1ya3C-2qmxA:
undetectable		 1ya3C-2qmxA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 LEU A 372
LEU A 375
LEU A 378
ALA A 379
GLN A 382
 None
 0.66A 1ya3C-2qveA:
undetectable		 1ya3C-2qveA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 LEU A 372
LEU A 375
LEU A 378
GLN A 382
LEU A 521
 None
 0.79A 1ya3C-2qveA:
undetectable		 1ya3C-2qveA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z55 ARCHAERHODOPSIN-2

(Halobacterium
sp. AUS-2) 		PF01036
(Bac_rhodopsin) 		5 LEU A  99
LEU A 102
LEU A 105
ALA A 106
LEU A 158
 None
 0.60A 1ya3C-2z55A:
undetectable		 1ya3C-2z55A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcw TRANSCRIPTIONAL
REGULATOR, FNR/CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 LEU A 187
LEU A 190
LEU A 193
ALA A 194
LEU A 129
 None
 0.84A 1ya3C-2zcwA:
undetectable		 1ya3C-2zcwA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7k HALORHODOPSIN

(Natronomonas
pharaonis) 		PF01036
(Bac_rhodopsin) 		5 LEU A 135
LEU A 138
LEU A 141
ALA A 142
LEU A 195
 None
None
None
None
L3P  A 331 (-3.7A)
 0.52A 1ya3C-3a7kA:
undetectable		 1ya3C-3a7kA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anv D-SERINE DEHYDRATASE

(Gallus gallus) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 LEU A 288
LEU A 341
ALA A 342
LEU A 248
THR A 351
 None
 1.08A 1ya3C-3anvA:
undetectable		 1ya3C-3anvA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 LEU A 985
LEU A 876
LEU A 784
GLN A 814
LEU A 778
 None
 1.05A 1ya3C-3bgaA:
undetectable		 1ya3C-3bgaA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq9 PREDICTED ROSSMANN
FOLD
NUCLEOTIDE-BINDING
DOMAIN-CONTAINING
PROTEIN

(Idiomarina
baltica) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		5 LEU A 422
LEU A 425
ALA A 428
GLN A 432
MET A 435
 None
None
None
GOL  A 463 ( 3.8A)
None
 1.14A 1ya3C-3bq9A:
undetectable		 1ya3C-3bq9A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edt KINESIN LIGHT CHAIN
2

(Homo sapiens) 		PF13374
(TPR_10)
PF13424
(TPR_12) 		5 LEU B 333
LEU B 330
ASN B 329
LEU B 327
LEU B 285
 None
 1.14A 1ya3C-3edtB:
undetectable		 1ya3C-3edtB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Aquifex
aeolicus) 		PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N) 		5 LEU A  38
LEU A  41
LEU A  44
ALA A  45
LEU A  21
 None
 0.90A 1ya3C-3hjlA:
undetectable		 1ya3C-3hjlA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7h INDIAN HEDGEHOG
PROTEIN

(Homo sapiens) 		PF01085
(HH_signal) 		5 LEU B 111
ASN B 112
LEU B 114
ALA B 115
MET B 103
 None
 1.13A 1ya3C-3k7hB:
undetectable		 1ya3C-3k7hB:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 715
ASN A 719
LEU A 721
GLN A 725
MET A 756
ARG A 766
LEU A 887
CYH A 891
THR A 894
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
 0.77A 1ya3C-3kbaA:
34.8		 1ya3C-3kbaA:
54.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 715
LEU A 718
ASN A 719
LEU A 721
MET A 756
ARG A 766
LEU A 887
CYH A 891
THR A 894
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
 0.56A 1ya3C-3kbaA:
34.8		 1ya3C-3kbaA:
54.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 5 LEU X 564
LEU X 561
LEU X 512
ALA X 511
LEU X 235
 None
 1.08A 1ya3C-3kvnX:
undetectable		 1ya3C-3kvnX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxh TRANSCRIPTIONAL
REGULATOR YVHJ

(Bacillus
subtilis) 		PF03816
(LytR_cpsA_psr) 		5 LEU A 239
ASN A 240
LEU A 242
LEU A 104
THR A 292
 None
 1.09A 1ya3C-3nxhA:
undetectable		 1ya3C-3nxhA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		11 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
MET A 108
LEU A 201
CYH A 205
THR A 208
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.49A 1ya3C-3ry9A:
36.9		 1ya3C-3ry9A:
69.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvi TYPE-2 RESTRICTION
ENZYME HINDIII

(Haemophilus
influenzae) 		PF09518
(RE_HindIII) 		5 LEU A 180
LEU A 175
LEU A 172
ALA A 173
LEU A 230
 None
 1.15A 1ya3C-3wviA:
undetectable		 1ya3C-3wviA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am9 CHAPERONE SYCD

(Yersinia
enterocolitica) 		PF07720
(TPR_3) 		6 LEU A  36
LEU A  39
LEU A  42
ALA A  43
GLN A  46
CYH A  63
 None
 0.82A 1ya3C-4am9A:
undetectable		 1ya3C-4am9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl6 PROTEIN BICAUDAL D

(Drosophila
melanogaster) 		PF09730
(BicD) 		5 LEU A 719
LEU A 722
LEU A 725
ALA A 726
GLN A 729
 None
 0.55A 1ya3C-4bl6A:
undetectable		 1ya3C-4bl6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehj PHOSPHOGLYCERATE
KINASE

(Francisella
tularensis) 		PF00162
(PGK) 		5 LEU A 198
LEU A 201
ASN A 202
LEU A 204
LEU A 246
 None
 1.03A 1ya3C-4ehjA:
undetectable		 1ya3C-4ehjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		5 LEU A  64
LEU A  60
LEU A  57
ALA A  58
LEU A  91
 None
 1.16A 1ya3C-4f3eA:
undetectable		 1ya3C-4f3eA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU A 645
LEU A 648
LEU A 651
ALA A 652
LEU A 669
 None
 0.98A 1ya3C-4fddA:
undetectable		 1ya3C-4fddA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		6 LEU A 324
LEU A 327
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.13A 1ya3C-4fdhA:
undetectable		 1ya3C-4fdhA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 324
LEU A 327
LEU A 330
ALA A 331
LEU A 186
 None
 1.12A 1ya3C-4fdhA:
undetectable		 1ya3C-4fdhA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia) 		PF00933
(Glyco_hydro_3) 		5 LEU A  35
ALA A  63
ARG A  54
LEU A  10
CYH A 284
 None
 0.96A 1ya3C-4g6cA:
undetectable		 1ya3C-4g6cA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE

(Stenotrophomonas
maltophilia) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 LEU A 159
LEU A 162
LEU A 165
ALA A 166
LEU A 139
 None
 1.02A 1ya3C-4grhA:
undetectable		 1ya3C-4grhA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica) 		PF00933
(Glyco_hydro_3) 		5 LEU A  31
ALA A  60
ARG A  50
LEU A   6
CYH A 279
 None
 0.95A 1ya3C-4gvfA:
undetectable		 1ya3C-4gvfA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		5 LEU L 592
LEU L 595
LEU L 598
ALA L 597
LEU N 239
 None
 1.11A 1ya3C-4heaL:
undetectable		 1ya3C-4heaL:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1c VACUOLAR CALCIUM ION
TRANSPORTER

(Saccharomyces
cerevisiae) 		PF01699
(Na_Ca_ex) 		5 LEU A  97
ASN A  98
LEU A  96
ALA A  99
LEU A  78
 None
 1.12A 1ya3C-4k1cA:
undetectable		 1ya3C-4k1cA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Schizosaccharomyces
pombe) 		PF12569
(NARP1) 		5 LEU A 115
LEU A 118
ALA A 119
GLN A 122
LEU A 152
 None
 0.78A 1ya3C-4kvoA:
undetectable		 1ya3C-4kvoA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 LEU A1196
LEU A1193
LEU A1190
LEU A1123
THR A1144
 None
 1.05A 1ya3C-4ll8A:
undetectable		 1ya3C-4ll8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)

(Candida
albicans) 		PF01965
(DJ-1_PfpI) 		5 LEU A  86
ASN A  85
LEU A  83
ALA A  82
LEU A   5
 None
 1.03A 1ya3C-4lruA:
undetectable		 1ya3C-4lruA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		7 LEU A 280
LEU A 283
LEU A 286
ALA A 287
MET A 321
ARG A 331
MET A 358
 None
 0.79A 1ya3C-4n1yA:
27.5		 1ya3C-4n1yA:
27.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
ARG A 611
LEU A 732
CYH A 736
THR A 739
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
 0.44A 1ya3C-4p6wA:
33.5		 1ya3C-4p6wA:
56.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwv P450 MONOOXYGENASE

(Streptomyces
sp. Acta 2897) 		PF00067
(p450) 		5 LEU A 172
LEU A 175
ASN A 176
ALA A 179
LEU A 200
 None
 1.07A 1ya3C-4pwvA:
undetectable		 1ya3C-4pwvA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmz EIF5B

(Chaetomium
thermophilum) 		no annotation 5 LEU B 529
LEU B 617
ALA B 646
LEU B 733
CYH B 526
 None
 1.15A 1ya3C-4tmzB:
undetectable		 1ya3C-4tmzB:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 766
LEU A 769
ASN A 770
LEU A 772
ALA A 773
GLN A 776
MET A 807
ARG A 817
LEU A 938
CYH A 942
THR A 945
 CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
 0.44A 1ya3C-4udbA:
36.3		 1ya3C-4udbA:
91.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9s PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sp. Mg1) 		PF00977
(His_biosynth) 		5 LEU A 204
LEU A 207
LEU A 210
ALA A 211
LEU A 238
 None
 1.02A 1ya3C-4x9sA:
undetectable		 1ya3C-4x9sA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 LEU A 132
LEU A  54
ASN A  55
LEU A  81
ALA A  80
 None
 1.17A 1ya3C-4xmvA:
undetectable		 1ya3C-4xmvA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5f BACTERIOPHYTOCHROME

(Deinococcus
radiodurans) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 LEU A  69
LEU A  42
LEU A  41
ALA A  40
LEU A 103
 None
 1.14A 1ya3C-4y5fA:
undetectable		 1ya3C-4y5fA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czl GLUCANASE

(Raoultella
ornithinolytica) 		PF01270
(Glyco_hydro_8) 		5 LEU A 306
LEU A 309
LEU A 312
ALA A 313
ARG A 106
 None
 1.01A 1ya3C-5czlA:
undetectable		 1ya3C-5czlA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		5 LEU A 283
ASN A 282
LEU A 280
ALA A 279
LEU A 263
 None
 1.09A 1ya3C-5ddbA:
undetectable		 1ya3C-5ddbA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		5 LEU A 286
LEU A 283
ASN A 282
LEU A 280
ALA A 279
 None
 0.96A 1ya3C-5ddbA:
undetectable		 1ya3C-5ddbA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE

(Escherichia
coli) 		PF02574
(S-methyl_trans) 		5 LEU A 245
LEU A 242
LEU A 239
ALA A 238
LEU A 203
 None
 1.10A 1ya3C-5dmnA:
undetectable		 1ya3C-5dmnA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Aspergillus
fumigatus) 		PF02358
(Trehalose_PPase) 		5 LEU A  46
LEU A  49
LEU A  52
ALA A  53
LEU A  83
 None
 0.98A 1ya3C-5dxlA:
undetectable		 1ya3C-5dxlA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 LEU A 527
LEU A 530
LEU A 533
ALA A 534
LEU A 582
 None
 1.11A 1ya3C-5irmA:
undetectable		 1ya3C-5irmA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 5 LEU A 739
LEU A 742
ALA A 746
MET A 722
THR A 663
 None
 1.01A 1ya3C-5m41A:
undetectable		 1ya3C-5m41A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgx PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP8

(Homo sapiens) 		PF00254
(FKBP_C)
PF07719
(TPR_2) 		5 LEU E 275
ASN E 276
LEU E 278
ALA E 279
GLN E 282
 None
 0.68A 1ya3C-5mgxE:
undetectable		 1ya3C-5mgxE:
25.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 12 LEU A 766
LEU A 769
ASN A 770
LEU A 772
ALA A 773
GLN A 776
MET A 807
ARG A 817
MET A 845
LEU A 938
CYH A 942
THR A 945
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
 0.54A 1ya3C-5mwpA:
38.1		 1ya3C-5mwpA:
73.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1t COPC

(Thioalkalivibrio
paradoxus) 		no annotation 5 LEU M  52
LEU M  55
ASN M  56
LEU M  58
ALA M  59
 None
 0.77A 1ya3C-5n1tM:
undetectable		 1ya3C-5n1tM:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nux CHROMATE REDUCTASE

(Thermus
scotoductus) 		no annotation 5 LEU A  80
LEU A  83
LEU A  86
ALA A  87
LEU A 162
 None
 1.05A 1ya3C-5nuxA:
undetectable		 1ya3C-5nuxA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 256
LEU A 259
ASN A 260
LEU A 262
ARG A  26
 None
 1.16A 1ya3C-5o0jA:
undetectable		 1ya3C-5o0jA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 5 LEU A 556
LEU A 559
LEU A 562
ALA A 563
MET A 545
 None
 1.07A 1ya3C-5o7eA:
undetectable		 1ya3C-5o7eA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 5 LEU A 559
ASN A 560
LEU A 562
ALA A 563
MET A 545
 None
 1.00A 1ya3C-5o7eA:
undetectable		 1ya3C-5o7eA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj8 KINESIN LIGHT CHAIN
1

(Homo sapiens) 		no annotation 5 LEU A 306
LEU A 303
ASN A 302
LEU A 300
LEU A 258
 None
 1.15A 1ya3C-5oj8A:
undetectable		 1ya3C-5oj8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 298
LEU A 301
ALA A 302
MET A 336
ARG A 346
 EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 ( 3.9A)
EST  A 601 ( 3.7A)
EST  A 601 (-4.1A)
 0.51A 1ya3C-5toaA:
24.3		 1ya3C-5toaA:
29.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
LEU A 562
GLN A 566
MET A 597
ARG A 607
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
 0.76A 1ya3C-5uc1A:
21.7		 1ya3C-5uc1A:
56.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  32
ASN A  33
LEU A  35
ARG A  80
MET A 108
THR A 208
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
1TA  A 301 (-3.0A)
 1.12A 1ya3C-5ufsA:
35.3		 1ya3C-5ufsA:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		9 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
LEU A 201
CYH A 205
THR A 208
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.8A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
 0.40A 1ya3C-5ufsA:
35.3		 1ya3C-5ufsA:
62.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS02G0668100 PROTEIN
OS07G0580900 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		5 LEU C 145
LEU C 148
LEU C 151
ALA C 152
LEU A 152
 None
 1.06A 1ya3C-5xn6C:
undetectable		 1ya3C-5xn6C:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL

(Homo sapiens) 		PF00384
(Molybdopterin)
PF09326
(NADH_dhqG_C)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 LEU M 357
LEU M 354
LEU M 351
ALA M 350
LEU M 584
 None
 1.15A 1ya3C-5xtbM:
undetectable		 1ya3C-5xtbM:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL3

(Homo sapiens) 		no annotation 5 LEU M 298
LEU M 304
ALA M 305
MET M 180
LEU M 282
 None
 0.95A 1ya3C-6cetM:
undetectable		 1ya3C-6cetM:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 5 LEU K 610
LEU K 613
ASN K 614
LEU K 616
ALA K 617
 None
 0.90A 1ya3C-6d6qK:
undetectable		 1ya3C-6d6qK:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 LEU A1627
LEU A1630
ASN A1631
LEU A1633
THR A1774
 None
 0.97A 1ya3C-6ez8A:
undetectable		 1ya3C-6ez8A:
11.30