SIMILAR PATTERNS OF AMINO ACIDS FOR 1YA3_B_STRB2001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btc BETA-AMYLASE

(Glycine max) 		PF01373
(Glyco_hydro_14) 		3 LEU A 344
LEU A 396
MET A 441
 None
 0.76A 1ya3B-1btcA:
0.0		 1ya3B-1btcA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c39 CATION-DEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Bos taurus) 		PF02157
(Man-6-P_recep) 		3 LEU A  26
LEU A 124
MET A 147
 None
 0.78A 1ya3B-1c39A:
undetectable		 1ya3B-1c39A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fml RETINOL DEHYDRATASE

(Spodoptera
frugiperda) 		PF00685
(Sulfotransfer_1) 		3 LEU A 106
LEU A 169
MET A 174
 None
 0.77A 1ya3B-1fmlA:
undetectable		 1ya3B-1fmlA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase) 		3 LEU A 148
LEU A 156
MET A 142
 None
 0.78A 1ya3B-1fsuA:
0.0		 1ya3B-1fsuA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gks CYTOCHROME C551

(Halorhodospira
halophila) 		PF13442
(Cytochrome_CBB3) 		3 LEU A  44
LEU A  49
MET A  55
 HEM  A   0 (-3.6A)
None
HEM  A   0 (-2.3A)
 0.82A 1ya3B-1gksA:
undetectable		 1ya3B-1gksA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		3 LEU A 144
LEU A 138
MET A  52
 None
 0.70A 1ya3B-1jvwA:
undetectable		 1ya3B-1jvwA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 LEU B 756
LEU B 775
MET B 719
 None
 0.64A 1ya3B-1ldkB:
0.0		 1ya3B-1ldkB:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqa TAS PROTEIN

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		3 LEU A 307
LEU A  46
MET A   1
 None
 0.82A 1ya3B-1lqaA:
0.0		 1ya3B-1lqaA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1f INTERLEUKIN-19

(Homo sapiens) 		PF00726
(IL10) 		3 LEU A 146
LEU A  63
MET A  96
 None
 0.74A 1ya3B-1n1fA:
undetectable		 1ya3B-1n1fA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		3 LEU A 596
LEU A 400
MET A 494
 None
 0.74A 1ya3B-1pxyA:
0.0		 1ya3B-1pxyA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q14 HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		3 LEU A 102
LEU A 109
MET A  19
 None
 0.81A 1ya3B-1q14A:
0.1		 1ya3B-1q14A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		3 LEU A 438
LEU A 174
MET A 350
 None
 0.77A 1ya3B-1r6uA:
0.0		 1ya3B-1r6uA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		3 LEU A   6
LEU A  81
MET A  60
 None
NDP  A1501 (-4.1A)
NDP  A1501 (-4.8A)
 0.67A 1ya3B-1rpnA:
undetectable		 1ya3B-1rpnA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		3 LEU A 122
LEU A  42
MET A  82
 None
 0.54A 1ya3B-1ru3A:
undetectable		 1ya3B-1ru3A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME

(Arachis
hypogaea) 		PF00141
(peroxidase) 		3 LEU A  37
LEU A 101
MET A 273
 HEM  A 300 ( 4.5A)
None
HEM  A 300 ( 4.7A)
 0.80A 1ya3B-1schA:
undetectable		 1ya3B-1schA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x79 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1
RAB GTPASE BINDING
EFFECTOR PROTEIN 1

(Homo sapiens) 		PF03127
(GAT)
PF09311
(Rab5-bind) 		3 LEU A 277
LEU A 266
MET B 563
 None
 0.74A 1ya3B-1x79A:
undetectable		 1ya3B-1x79A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yg8 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Escherichia
coli) 		PF00574
(CLP_protease) 		3 LEU A 174
LEU A 103
MET A 153
 None
 0.60A 1ya3B-1yg8A:
undetectable		 1ya3B-1yg8A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr5 H2AFY PROTEIN

(Homo sapiens) 		PF01661
(Macro) 		3 LEU A 351
LEU A 184
MET A 364
 None
 0.77A 1ya3B-1zr5A:
undetectable		 1ya3B-1zr5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af7 GAMMA-CARBOXYMUCONOL
ACTONE DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF02627
(CMD) 		3 LEU A  59
LEU A  64
MET A  97
 None
 0.80A 1ya3B-2af7A:
undetectable		 1ya3B-2af7A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 LEU A  20
LEU A  25
MET A 177
 None
 0.81A 1ya3B-2cfmA:
undetectable		 1ya3B-2cfmA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddz 190AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF04017
(DUF366) 		3 LEU A  87
LEU A 172
MET A   4
 None
 0.82A 1ya3B-2ddzA:
undetectable		 1ya3B-2ddzA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqw DIHYDROPTEROATE
SYNTHASE

(Thermus
thermophilus) 		PF00809
(Pterin_bind) 		3 LEU A  71
LEU A  32
MET A  61
 None
 0.77A 1ya3B-2dqwA:
undetectable		 1ya3B-2dqwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		3 LEU A 677
LEU A 697
MET A 332
 None
 0.51A 1ya3B-2dw4A:
undetectable		 1ya3B-2dw4A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwa GLUTAMINE
CYCLOTRANSFERASE

(Carica papaya) 		PF05096
(Glu_cyclase_2) 		3 LEU A 179
LEU A 141
MET A 128
 None
 0.78A 1ya3B-2iwaA:
undetectable		 1ya3B-2iwaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jpc SSRB

(Salmonella
enterica) 		PF00196
(GerE) 		3 LEU A  23
LEU A  64
MET A  51
 None
 0.75A 1ya3B-2jpcA:
undetectable		 1ya3B-2jpcA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3e NEUROLYSIN

(Rattus
norvegicus) 		PF01432
(Peptidase_M3) 		3 LEU A 647
LEU A 645
MET A 623
 None
 0.81A 1ya3B-2o3eA:
undetectable		 1ya3B-2o3eA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus) 		PF12796
(Ank_2) 		3 LEU A 219
LEU A 205
MET A 162
 LEU  A 219 ( 0.6A)
LEU  A 205 ( 0.5A)
LEU  A 216 ( 3.6A)
 0.79A 1ya3B-2pnnA:
undetectable		 1ya3B-2pnnA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		3 LEU A 539
LEU A 537
MET A 432
 None
 0.80A 1ya3B-2qvwA:
undetectable		 1ya3B-2qvwA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zrr MUNDTICIN KS
IMMUNITY PROTEIN

(Enterococcus
mundtii) 		PF08951
(EntA_Immun) 		3 LEU A  24
LEU A  45
MET A  62
 None
 0.62A 1ya3B-2zrrA:
undetectable		 1ya3B-2zrrA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 LEU A 884
LEU A 878
MET A 769
 None
 0.69A 1ya3B-3c10A:
undetectable		 1ya3B-3c10A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00196
(GerE) 		3 LEU A   6
LEU A  53
MET A  90
 None
 0.53A 1ya3B-3c3wA:
undetectable		 1ya3B-3c3wA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5y RIBOSE/GALACTOSE
ISOMERASE

(Novosphingobium
aromaticivorans) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		3 LEU A 180
LEU A  55
MET A  85
 None
 0.75A 1ya3B-3c5yA:
undetectable		 1ya3B-3c5yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dad FH1/FH2
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 3 LEU A 274
LEU A 259
MET A 306
 None
 0.80A 1ya3B-3dadA:
undetectable		 1ya3B-3dadA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkb PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
avermitilis) 		PF00378
(ECH_1) 		3 LEU A 271
LEU A 250
MET A  70
 None
 0.71A 1ya3B-3gkbA:
undetectable		 1ya3B-3gkbA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		3 LEU A 406
LEU A 311
MET A 376
 None
 0.63A 1ya3B-3hidA:
undetectable		 1ya3B-3hidA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 LEU A 365
LEU A 371
MET A 527
 None
 0.68A 1ya3B-3hztA:
undetectable		 1ya3B-3hztA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		3 LEU A1387
LEU A1417
MET A1370
 None
 0.72A 1ya3B-3ig3A:
undetectable		 1ya3B-3ig3A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfo PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		3 LEU A 178
LEU A 169
MET A 204
 None
 0.64A 1ya3B-3qfoA:
undetectable		 1ya3B-3qfoA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyj ALR0039 PROTEIN

(Nostoc sp. PCC
7120) 		PF00561
(Abhydrolase_1) 		3 LEU A  31
LEU A  28
MET A  90
 None
 0.82A 1ya3B-3qyjA:
undetectable		 1ya3B-3qyjA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz1 STEROID
21-HYDROXYLASE

(Bos taurus) 		PF00067
(p450) 		3 LEU A 428
LEU A 129
MET A 255
 HEM  A 500 (-3.8A)
None
None
 0.51A 1ya3B-3qz1A:
undetectable		 1ya3B-3qz1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt PLEXIN-A1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		3 LEU A1409
LEU A1439
MET A1392
 None
 0.68A 1ya3B-3rytA:
undetectable		 1ya3B-3rytA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7b ACETYLGLUTAMATE
KINASE

(Yersinia pestis) 		PF00696
(AA_kinase) 		3 LEU A 185
LEU A 203
MET A 213
 None
 0.76A 1ya3B-3t7bA:
undetectable		 1ya3B-3t7bA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 LEU A 397
LEU A 332
MET A 306
 None
 0.73A 1ya3B-3v5rA:
undetectable		 1ya3B-3v5rA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT) 		3 LEU A1129
LEU A1149
MET A1268
 None
 0.79A 1ya3B-4bujA:
1.9		 1ya3B-4bujA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Neurospora
crassa) 		no annotation 3 LEU A 616
LEU A 573
MET A 635
 None
 0.52A 1ya3B-4bwkA:
undetectable		 1ya3B-4bwkA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		3 LEU A1738
LEU A1780
MET A1766
 None
 0.67A 1ya3B-4by6A:
undetectable		 1ya3B-4by6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czb NA(+)/H(+)
ANTIPORTER 1

(Methanocaldococcus
jannaschii) 		PF00999
(Na_H_Exchanger) 		3 LEU A 221
LEU A 228
MET A 254
 None
 0.70A 1ya3B-4czbA:
undetectable		 1ya3B-4czbA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czx PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Neurospora
crassa) 		no annotation 3 LEU B 616
LEU B 573
MET B 635
 None
 0.80A 1ya3B-4czxB:
undetectable		 1ya3B-4czxB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		3 LEU A 129
LEU A  61
MET A 113
 None
 0.63A 1ya3B-4hesA:
undetectable		 1ya3B-4hesA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		3 LEU A  73
LEU A 115
MET A 471
 None
 0.73A 1ya3B-4i3uA:
undetectable		 1ya3B-4i3uA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is7 CASKIN-2

(Homo sapiens) 		PF00536
(SAM_1) 		3 LEU A 103
LEU A  97
MET A 120
 None
 0.77A 1ya3B-4is7A:
undetectable		 1ya3B-4is7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		3 LEU A 552
LEU A 534
MET A 582
 None
 0.72A 1ya3B-4kf7A:
undetectable		 1ya3B-4kf7A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8t UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF01843
(DIL) 		3 LEU A1631
LEU A1588
MET A1516
 None
 0.71A 1ya3B-4l8tA:
undetectable		 1ya3B-4l8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		3 LEU A1231
LEU A1193
MET A1296
 None
 0.79A 1ya3B-4ll6A:
undetectable		 1ya3B-4ll6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		3 LEU A1231
LEU A1193
MET A1296
 None
 0.82A 1ya3B-4ll8A:
undetectable		 1ya3B-4ll8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mu9 GLYCOSIDE HYDROLASE
FAMILY 73

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		3 LEU A 169
LEU A 148
MET A  86
 None
 0.80A 1ya3B-4mu9A:
undetectable		 1ya3B-4mu9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mve UNCHARACTERIZED
PROTEIN

(Thermomonospora
curvata) 		PF14231
(GXWXG)
PF14232
(DUF4334) 		3 LEU A  75
LEU A  92
MET A 108
 None
 0.60A 1ya3B-4mveA:
undetectable		 1ya3B-4mveA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phq HEMOLYSIN E,
CHROMOSOMAL

(Escherichia
coli) 		PF06109
(HlyE) 		3 LEU A 120
LEU A  93
MET A 281
 None
 0.51A 1ya3B-4phqA:
undetectable		 1ya3B-4phqA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 LEU A 475
LEU A 450
MET A 304
 None
 0.77A 1ya3B-4pj3A:
undetectable		 1ya3B-4pj3A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0v FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		3 LEU A 145
LEU A 307
MET A 334
 None
 0.79A 1ya3B-4r0vA:
undetectable		 1ya3B-4r0vA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcd BETA-SECRETASE 1

(Homo sapiens) 		PF00026
(Asp) 		3 LEU A 121
LEU A  30
MET A  18
 None
3LL  A 501 (-4.2A)
None
 0.53A 1ya3B-4rcdA:
undetectable		 1ya3B-4rcdA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		3 LEU A 135
LEU A  17
MET A  27
 None
 0.73A 1ya3B-4rxeA:
undetectable		 1ya3B-4rxeA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6u COG5
COG7

(Kluyveromyces
lactis) 		PF10392
(COG5)
no annotation 		3 LEU A  30
LEU B 130
MET A  53
 None
 0.63A 1ya3B-4u6uA:
undetectable		 1ya3B-4u6uA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio cholerae) 		PF04205
(FMN_bind) 		3 LEU C 221
LEU C 145
MET C 149
 None
FMN  C 301 (-4.4A)
None
 0.81A 1ya3B-4u9sC:
undetectable		 1ya3B-4u9sC:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LEU A 769
LEU A 810
MET A 852
 CV7  A1987 (-4.1A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 3.7A)
 0.23A 1ya3B-4udbA:
36.8		 1ya3B-4udbA:
91.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5w RIBULOSE
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E ACTIVASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00004
(AAA) 		3 LEU A 172
LEU A 232
MET A 242
 None
 0.72A 1ya3B-4w5wA:
undetectable		 1ya3B-4w5wA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wau CENTROMERE PROTEIN M

(Homo sapiens) 		PF11111
(CENP-M) 		3 LEU A 100
LEU A  28
MET A  35
 None
 0.77A 1ya3B-4wauA:
undetectable		 1ya3B-4wauA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		3 LEU A  59
LEU A 389
MET A 374
 None
 0.76A 1ya3B-4wgxA:
undetectable		 1ya3B-4wgxA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN

(Thielavia
terrestris) 		PF07470
(Glyco_hydro_88) 		3 LEU A 103
LEU A  60
MET A 368
 None
 0.69A 1ya3B-4xuvA:
undetectable		 1ya3B-4xuvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 LEU A 418
LEU A 498
MET A 446
 None
 0.77A 1ya3B-4zlgA:
undetectable		 1ya3B-4zlgA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE
FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt)
no annotation 		3 LEU B 135
LEU A  17
MET A  27
 None
 0.66A 1ya3B-5ahuB:
undetectable		 1ya3B-5ahuB:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce7 CTD KINASE SUBUNIT
GAMMA

(Schizosaccharomyces
pombe) 		PF12243
(CTK3) 		3 LEU A  35
LEU A  41
MET A  83
 None
 0.71A 1ya3B-5ce7A:
undetectable		 1ya3B-5ce7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs0 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		3 LEU A 900
LEU A 850
MET A 862
 None
 0.80A 1ya3B-5cs0A:
undetectable		 1ya3B-5cs0A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		3 LEU A  27
LEU A 106
MET A  95
 None
 0.78A 1ya3B-5dz7A:
undetectable		 1ya3B-5dz7A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		3 LEU A 252
LEU A 328
MET A 338
 None
 0.80A 1ya3B-5ee7A:
undetectable		 1ya3B-5ee7A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C) 		3 LEU A 406
LEU A 208
MET A 274
 None
 0.77A 1ya3B-5es9A:
undetectable		 1ya3B-5es9A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LEU A 941
LEU A 851
MET A1008
 None
 0.77A 1ya3B-5fm2A:
undetectable		 1ya3B-5fm2A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 LEU B 191
LEU B 189
MET B 282
 None
 0.81A 1ya3B-5fq6B:
undetectable		 1ya3B-5fq6B:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT

(Escherichia
coli) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		3 LEU B  34
LEU A 120
MET A 125
 FAD  B 321 (-4.0A)
None
None
 0.70A 1ya3B-5g5gB:
undetectable		 1ya3B-5g5gB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0p BETA-LACTAMASE
DOMAIN PROTEIN

(Burkholderia
ambifaria) 		PF00753
(Lactamase_B) 		3 LEU A 246
LEU A 331
MET A 312
 None
 0.74A 1ya3B-5i0pA:
undetectable		 1ya3B-5i0pA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 LEU A 520
LEU A 512
MET A 666
 None
 0.81A 1ya3B-5ja1A:
undetectable		 1ya3B-5ja1A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 LEU A 485
LEU A 411
MET A 518
 None
 0.79A 1ya3B-5jm7A:
undetectable		 1ya3B-5jm7A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k34 ANKYRIN-REPEAT
PROTEIN B

(Legionella
pneumophila) 		no annotation 3 LEU A  99
LEU A 113
MET A 159
 None
 0.62A 1ya3B-5k34A:
undetectable		 1ya3B-5k34A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k35 ANKYRIN-REPEAT
PROTEIN B

(Legionella
pneumophila) 		PF12937
(F-box-like) 		3 LEU A  99
LEU A 113
MET A 159
 None
 0.74A 1ya3B-5k35A:
undetectable		 1ya3B-5k35A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF00420
(Oxidored_q2)
PF06444
(NADH_dehy_S2_C) 		3 LEU K  20
LEU N  61
MET N 104
 None
 0.58A 1ya3B-5lc5K:
undetectable		 1ya3B-5lc5K:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mea CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		no annotation 3 LEU A 327
LEU A 343
MET A 350
 None
 0.78A 1ya3B-5meaA:
undetectable		 1ya3B-5meaA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mec CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		no annotation 3 LEU A 327
LEU A 343
MET A 350
 None
 0.81A 1ya3B-5mecA:
undetectable		 1ya3B-5mecA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		3 LEU A 773
LEU A 779
MET A 846
 None
 0.77A 1ya3B-5mqsA:
undetectable		 1ya3B-5mqsA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5a PEREGRIN

(Homo sapiens) 		no annotation 3 LEU A 637
LEU A 630
MET A 739
 None
 0.75A 1ya3B-5o5aA:
undetectable		 1ya3B-5o5aA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ooo NON-STRUCTURAL
PROTEIN NS-S

(Rift Valley
fever
phlebovirus) 		PF11073
(NSs) 		3 LEU A 197
LEU A 215
MET A  96
 None
 0.75A 1ya3B-5oooA:
undetectable		 1ya3B-5oooA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		3 LEU A 540
LEU A 594
MET A 644
 None
 0.78A 1ya3B-5t8vA:
undetectable		 1ya3B-5t8vA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td7 ZGC:55652

(Danio rerio) 		PF00850
(Hist_deacetyl) 		3 LEU A 549
LEU A 594
MET A 601
 None
 0.81A 1ya3B-5td7A:
undetectable		 1ya3B-5td7A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR

(Saccharomyces
cerevisiae) 		PF03399
(SAC3_GANP) 		3 LEU A 272
LEU A 265
MET A 203
 None
 0.81A 1ya3B-5ubpA:
undetectable		 1ya3B-5ubpA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukv ATP-BINDING PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 3 LEU A 304
LEU A 310
MET A 250
 None
None
PG4  A 403 ( 4.2A)
 0.82A 1ya3B-5ukvA:
undetectable		 1ya3B-5ukvA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao1 BETA-LACTAMASE
DOMAIN PROTEIN

(Paraburkholderia
phymatum) 		PF00753
(Lactamase_B) 		3 LEU A 246
LEU A 330
MET A 312
 None
 0.63A 1ya3B-6ao1A:
undetectable		 1ya3B-6ao1A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axf RAS GUANYL-RELEASING
PROTEIN 2

(Homo sapiens) 		no annotation 3 LEU A 364
LEU A 149
MET A 210
 None
 0.81A 1ya3B-6axfA:
undetectable		 1ya3B-6axfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cer PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
ALPHA, SOMATIC FORM,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 LEU A 231
LEU A 290
MET A  39
 None
 0.76A 1ya3B-6cerA:
undetectable		 1ya3B-6cerA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 3 LEU A 530
LEU A 439
MET A 427
 None
B7E  A 901 (-4.6A)
None
 0.53A 1ya3B-6ej2A:
undetectable		 1ya3B-6ej2A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2d FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIP
FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIQ
FLAGELLAR
BIOSYNTHETIC PROTEIN
FLIR

(Salmonella
enterica) 		no annotation 3 LEU F 125
LEU A 194
MET G  14
 None
 0.52A 1ya3B-6f2dF:
undetectable		 1ya3B-6f2dF:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 3 LEU A 941
LEU A 851
MET A1008
 None
 0.78A 1ya3B-6fekA:
undetectable		 1ya3B-6fekA:
17.62