SIMILAR PATTERNS OF AMINO ACIDS FOR 1YA3_A_STRA1001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0p SITE-SPECIFIC
RECOMBINASE XERD

(Escherichia
coli) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		4 LEU A  40
LEU A  33
SER A  34
LEU A   5
 None
 1.18A 1ya3A-1a0pA:
0.2		 1ya3A-1a0pA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 246
LEU A 169
SER A 170
LEU A  60
 None
 1.17A 1ya3A-1ciyA:
0.8		 1ya3A-1ciyA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyd CARBONYL REDUCTASE

(Mus musculus) 		PF13561
(adh_short_C2) 		4 LEU A   8
LEU A 223
SER A 224
LEU A   3
 None
 1.16A 1ya3A-1cydA:
undetectable		 1ya3A-1cydA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dc1 BSOBI RESTRICTION
ENDONUCLEASE

(Geobacillus
stearothermophilus) 		PF09194
(Endonuc-BsobI) 		4 LEU A  63
LEU A  98
SER A  94
LEU A  73
 None
None
DIO  A1008 (-3.3A)
None
 1.11A 1ya3A-1dc1A:
0.0		 1ya3A-1dc1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izm HYPOTHETICAL PROTEIN
HI0817

(Haemophilus
influenzae) 		PF03695
(UPF0149) 		4 LEU A  36
LEU A  28
SER A  29
LEU A  74
 None
 1.12A 1ya3A-1izmA:
undetectable		 1ya3A-1izmA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwe PROTEIN (DNAB
HELICASE)

(Escherichia
coli) 		PF00772
(DnaB) 		4 LEU A  83
LEU A  90
SER A  89
LEU A  74
 None
 1.18A 1ya3A-1jweA:
0.0		 1ya3A-1jweA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 LEU A 510
LEU A 505
SER A 502
LEU A 453
 None
 1.10A 1ya3A-1qgrA:
0.0		 1ya3A-1qgrA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzg PROTECTION OF
TELOMERES PROTEIN 1

(Schizosaccharomyces
pombe) 		PF02765
(POT1) 		4 LEU A  83
LEU A 122
SER A 123
LEU A  87
 None
 1.04A 1ya3A-1qzgA:
undetectable		 1ya3A-1qzgA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1skx ORPHAN NUCLEAR
RECEPTOR PXR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 154
LEU A 348
SER A 347
LEU A 286
 None
 0.91A 1ya3A-1skxA:
19.6		 1ya3A-1skxA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		4 LEU A 419
LEU A 378
SER A 401
LEU A 408
 None
 1.06A 1ya3A-1ytmA:
undetectable		 1ya3A-1ytmA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C

(Wolinella
succinogenes) 		PF01127
(Sdh_cyt) 		4 LEU C 225
LEU C 220
SER C 217
LEU C 181
 None
 1.01A 1ya3A-2bs4C:
0.0		 1ya3A-2bs4C:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		4 LEU A 214
LEU A 175
SER A 173
LEU A 221
 None
 1.17A 1ya3A-2g02A:
undetectable		 1ya3A-2g02A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g40 CONSERVED
HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02589
(LUD_dom) 		4 LEU A 117
LEU A 143
SER A 144
LEU A 132
 None
 0.96A 1ya3A-2g40A:
undetectable		 1ya3A-2g40A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gop TRILOBED PROTEASE

(Pyrococcus
furiosus) 		PF07676
(PD40) 		4 LEU A 101
LEU A 109
SER A 108
LEU A 119
 None
 1.17A 1ya3A-2gopA:
undetectable		 1ya3A-2gopA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5r MSTRAWBERRY

(Discosoma sp.) 		PF01353
(GFP) 		4 LEU A 189
LEU A  85
SER A  86
LEU A  83
 None
 1.03A 1ya3A-2h5rA:
undetectable		 1ya3A-2h5rA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		4 LEU A 249
LEU A 236
SER A 237
LEU A 352
 None
 1.12A 1ya3A-2hb6A:
undetectable		 1ya3A-2hb6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 276
LEU A 306
SER A 307
LEU A 289
 None
 1.10A 1ya3A-2i6tA:
undetectable		 1ya3A-2i6tA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus) 		PF04960
(Glutaminase) 		4 LEU A 145
LEU A  63
SER A  67
LEU A 138
 None
 1.19A 1ya3A-2pbyA:
undetectable		 1ya3A-2pbyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		4 LEU A 510
LEU A 505
SER A 502
LEU A 453
 None
 0.96A 1ya3A-2qnaA:
undetectable		 1ya3A-2qnaA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsv UNCHARACTERIZED
PROTEIN

(Porphyromonas
gingivalis) 		PF07610
(DUF1573) 		4 LEU A 178
LEU A 122
SER A 123
LEU A 126
 None
 1.13A 1ya3A-2qsvA:
undetectable		 1ya3A-2qsvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 LEU A 121
LEU A  17
SER A  18
LEU A  60
 None
 0.94A 1ya3A-2rgjA:
undetectable		 1ya3A-2rgjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25

(Homo sapiens) 		PF00621
(RhoGEF) 		4 LEU B 222
LEU B 168
SER B 166
LEU B 229
 None
 1.06A 1ya3A-2rgnB:
undetectable		 1ya3A-2rgnB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN

(Mycobacterium
tuberculosis) 		PF09754
(PAC2) 		4 LEU A 108
LEU A 105
SER A 104
LEU A  69
 None
 1.16A 1ya3A-2wamA:
undetectable		 1ya3A-2wamA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb7 PT26-6P

(Thermococcus
sp. 26-2) 		no annotation 4 LEU A 388
LEU A 393
SER A 394
LEU A 391
 None
 1.16A 1ya3A-2wb7A:
undetectable		 1ya3A-2wb7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 LEU A 505
LEU A 484
SER A 480
LEU A 461
 None
 1.10A 1ya3A-2xdfA:
undetectable		 1ya3A-2xdfA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xes PROTEIN PAT1 HOMOLOG
1

(Homo sapiens) 		PF09770
(PAT1) 		4 LEU A 601
LEU A 642
SER A 641
LEU A 637
 None
 1.13A 1ya3A-2xesA:
undetectable		 1ya3A-2xesA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		4 LEU A 148
LEU A  35
SER A  36
LEU A 154
 BR  A1302 ( 4.9A)
None
None
None
 0.95A 1ya3A-2ykfA:
undetectable		 1ya3A-2ykfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 LEU A 233
LEU A  26
SER A  27
LEU A  80
 None
 1.11A 1ya3A-2z5xA:
undetectable		 1ya3A-2z5xA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU B 129
LEU B 121
SER B 122
LEU B 168
 None
 1.11A 1ya3A-2z7xB:
undetectable		 1ya3A-2z7xB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU B 136
LEU B 128
SER B 129
LEU B 175
 None
 0.97A 1ya3A-3a79B:
undetectable		 1ya3A-3a79B:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 112
LEU A  84
SER A  83
LEU A 335
 None
 0.95A 1ya3A-3bn1A:
undetectable		 1ya3A-3bn1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btz ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 2

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		4 LEU A  72
LEU A 251
SER A 186
LEU A 218
 None
 0.90A 1ya3A-3btzA:
undetectable		 1ya3A-3btzA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbg O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF01596
(Methyltransf_3) 		4 LEU A  82
LEU A  76
SER A  74
LEU A  52
 None
None
SAH  A 301 (-2.9A)
None
 1.17A 1ya3A-3cbgA:
undetectable		 1ya3A-3cbgA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 GAMMA
CHAIN

(Escherichia
coli) 		PF02665
(Nitrate_red_gam) 		4 LEU C 102
LEU C 133
SER C 131
LEU C 109
 None
HEM  C 806 ( 4.8A)
None
None
 1.06A 1ya3A-3egwC:
undetectable		 1ya3A-3egwC:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h75 PERIPLASMIC
SUGAR-BINDING DOMAIN
PROTEIN

(Pseudomonas
protegens) 		PF13407
(Peripla_BP_4) 		4 LEU A 104
LEU A 129
SER A 130
LEU A 137
 None
 1.19A 1ya3A-3h75A:
undetectable		 1ya3A-3h75A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3him PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 LEU A  63
LEU A  69
SER A  68
LEU A 121
 None
 1.15A 1ya3A-3himA:
undetectable		 1ya3A-3himA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwe MGLL PROTEIN

(Homo sapiens) 		PF12146
(Hydrolase_4) 		4 LEU A 271
LEU A 154
SER A 156
LEU A 281
 None
 0.99A 1ya3A-3jweA:
undetectable		 1ya3A-3jweA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k12 UNCHARACTERIZED
PROTEIN A6V7T0

(Pseudomonas
aeruginosa) 		PF01042
(Ribonuc_L-PSP) 		4 LEU A  79
LEU A  99
SER A  98
LEU A  69
 None
 1.11A 1ya3A-3k12A:
undetectable		 1ya3A-3k12A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p PROTEIN TRANSPORT
PROTEIN SEC39

(Saccharomyces
cerevisiae) 		PF08314
(Sec39) 		4 LEU D 385
LEU D 362
SER D 360
LEU D 356
 None
 1.01A 1ya3A-3k8pD:
undetectable		 1ya3A-3k8pD:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m88 AMOEBIASIN-2

(Entamoeba
histolytica) 		PF09394
(Inhibitor_I42) 		4 LEU A  91
LEU A  63
SER A  64
LEU A  37
 None
 1.18A 1ya3A-3m88A:
undetectable		 1ya3A-3m88A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meb ASPARTATE
AMINOTRANSFERASE

(Giardia
intestinalis) 		PF00155
(Aminotran_1_2) 		4 LEU A 365
LEU A 347
SER A 346
LEU A 342
 None
 1.14A 1ya3A-3mebA:
undetectable		 1ya3A-3mebA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncc PROLACTIN

(Homo sapiens) 		PF00103
(Hormone_1) 		4 LEU A 127
LEU A  25
SER A  26
LEU A 186
 None
 1.12A 1ya3A-3nccA:
undetectable		 1ya3A-3nccA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		4 LEU A 175
LEU A 170
SER A 167
LEU A 184
 None
 1.18A 1ya3A-3o75A:
undetectable		 1ya3A-3o75A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 LEU A 362
LEU A 392
SER A 393
LEU A  52
 None
 1.14A 1ya3A-3tk3A:
2.3		 1ya3A-3tk3A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukm POTASSIUM CHANNEL
SUBFAMILY K MEMBER 1

(Homo sapiens) 		PF07885
(Ion_trans_2) 		4 LEU A 146
LEU A 115
SER A 116
LEU A 257
 None
 1.06A 1ya3A-3ukmA:
undetectable		 1ya3A-3ukmA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uoe DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02615
(Ldh_2) 		4 LEU A  52
LEU A  15
SER A  12
LEU A  46
 None
 1.13A 1ya3A-3uoeA:
undetectable		 1ya3A-3uoeA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 LEU A 376
LEU A 480
SER A 476
LEU A 383
 None
 1.01A 1ya3A-3w9hA:
undetectable		 1ya3A-3w9hA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		4 LEU A 309
LEU A 297
SER A 294
LEU A 327
 None
 1.07A 1ya3A-3wqyA:
0.4		 1ya3A-3wqyA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxe GALECTIN-7

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 LEU A  37
LEU A  48
SER A  63
LEU A 113
 None
 1.12A 1ya3A-3zxeA:
undetectable		 1ya3A-3zxeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 LEU A 546
LEU A 480
SER A 478
LEU A 553
 None
 1.15A 1ya3A-4a2wA:
undetectable		 1ya3A-4a2wA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 246
LEU A 169
SER A 170
LEU A  60
 None
 1.18A 1ya3A-4arxA:
undetectable		 1ya3A-4arxA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayi LIPOPROTEIN GNA1870
CCOMPND 7

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		4 LEU D 133
LEU D  99
SER D 127
LEU D  89
 None
 1.18A 1ya3A-4ayiD:
undetectable		 1ya3A-4ayiD:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		4 LEU A 158
LEU A 203
SER A 204
LEU A 197
 None
IMD  A1342 ( 4.8A)
None
None
 1.17A 1ya3A-4bf7A:
undetectable		 1ya3A-4bf7A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL

(Homo sapiens) 		PF07992
(Pyr_redox_2)
PF14721
(AIF_C) 		4 LEU A 293
LEU A 175
SER A 176
LEU A 311
 None
FAD  A1449 ( 4.7A)
FAD  A1449 (-3.6A)
FAD  A1449 ( 4.7A)
 1.13A 1ya3A-4bv6A:
undetectable		 1ya3A-4bv6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c76 FMN REDUCTASE
(NADPH)

(Pseudomonas
putida) 		PF03358
(FMN_red) 		4 LEU A 100
LEU A  49
SER A  50
LEU A  93
 None
 1.13A 1ya3A-4c76A:
undetectable		 1ya3A-4c76A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		4 LEU A 196
LEU A 189
SER A 190
LEU A 228
 None
 1.09A 1ya3A-4cemA:
undetectable		 1ya3A-4cemA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 LEU B 139
LEU B 147
SER B 146
LEU B 117
 None
 1.06A 1ya3A-4htfB:
undetectable		 1ya3A-4htfB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
fluorescens) 		PF04909
(Amidohydro_2) 		4 LEU A 204
LEU A 211
SER A 212
LEU A 209
 None
 1.09A 1ya3A-4ifrA:
undetectable		 1ya3A-4ifrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		4 LEU A1226
LEU A1055
SER A1056
LEU A1115
 None
 1.11A 1ya3A-4kegA:
undetectable		 1ya3A-4kegA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11

(synthetic
construct) 		PF01353
(GFP) 		4 LEU C 229
LEU C  85
SER C  86
LEU C  83
 None
 0.96A 1ya3A-4kf5C:
undetectable		 1ya3A-4kf5C:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll1 THIOREDOXIN-INTERACT
ING PROTEIN

(Homo sapiens) 		PF00339
(Arrestin_N)
PF02752
(Arrestin_C) 		4 LEU A 234
LEU A 294
SER A 275
LEU A 277
 None
 1.14A 1ya3A-4ll1A:
undetectable		 1ya3A-4ll1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		4 LEU A 361
LEU A 249
SER A 245
LEU A 354
 None
 1.12A 1ya3A-4mm0A:
undetectable		 1ya3A-4mm0A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1)
PF16842
(RRM_occluded) 		4 LEU A 313
LEU A 316
SER A 384
LEU A 369
 None
 1.17A 1ya3A-4n0tA:
undetectable		 1ya3A-4n0tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 LEU A 373
LEU A 301
SER A 298
LEU A 350
 None
 1.13A 1ya3A-4pv4A:
undetectable		 1ya3A-4pv4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0y UNCHARACTERIZED
PROTEIN

(Clostridium
sporogenes) 		no annotation 4 LEU A 120
LEU A 123
SER A 131
LEU A 152
 None
 0.97A 1ya3A-4q0yA:
undetectable		 1ya3A-4q0yA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		4 LEU A 389
LEU A  24
SER A  25
LEU A 413
 None
 1.19A 1ya3A-4q22A:
undetectable		 1ya3A-4q22A:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 769
LEU A 810
SER A 811
LEU A 938
 CV7  A1987 (-4.1A)
CV7  A1987 (-4.0A)
None
CV7  A1987 ( 3.9A)
 0.41A 1ya3A-4udbA:
37.2		 1ya3A-4udbA:
91.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		4 LEU A 422
LEU A 461
SER A 459
LEU A 456
 None
 1.17A 1ya3A-4uvkA:
undetectable		 1ya3A-4uvkA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE

(Picrophilus
torridus) 		PF00701
(DHDPS) 		4 LEU A 226
LEU A 193
SER A 192
LEU A 188
 None
 1.13A 1ya3A-4uxdA:
undetectable		 1ya3A-4uxdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 246
LEU A 169
SER A 170
LEU A  60
 None
 1.13A 1ya3A-4w8jA:
undetectable		 1ya3A-4w8jA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfq SUPPRESSOR OF
STEM-LOOP PROTEIN 1

(Saccharomyces
cerevisiae) 		PF04056
(Ssl1) 		4 LEU A 300
LEU A 266
SER A 267
LEU A 292
 None
 1.15A 1ya3A-4wfqA:
undetectable		 1ya3A-4wfqA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x68 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00144
(Beta-lactamase) 		4 LEU A 384
LEU A  60
SER A  59
LEU A 266
 None
 0.95A 1ya3A-4x68A:
undetectable		 1ya3A-4x68A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Saccharomyces
cerevisiae) 		PF12569
(NARP1) 		4 LEU A 368
LEU A 363
SER A 360
LEU A 397
 None
 1.19A 1ya3A-4xpdA:
undetectable		 1ya3A-4xpdA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtl SODIUM PUMPING
RHODOPSIN

(Dokdonia
eikasta) 		PF01036
(Bac_rhodopsin) 		4 LEU A 121
LEU A  63
SER A  64
LEU A 262
 None
None
LYR  A 255 ( 4.9A)
None
 1.08A 1ya3A-4xtlA:
undetectable		 1ya3A-4xtlA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhb IRON-CHELATOR
UTILIZATION PROTEIN

(Thermobifida
fusca) 		PF04954
(SIP)
PF08021
(FAD_binding_9) 		4 LEU A  56
LEU A 129
SER A  17
LEU A  68
 None
None
None
MPD  A 303 (-4.6A)
 1.09A 1ya3A-4yhbA:
undetectable		 1ya3A-4yhbA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 LEU A2056
LEU A1932
SER A1931
LEU A1927
 None
 1.14A 1ya3A-5a22A:
undetectable		 1ya3A-5a22A:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12862
(ANAPC5) 		4 LEU O 402
LEU O 384
SER O 383
LEU O 379
 None
 1.03A 1ya3A-5a31O:
undetectable		 1ya3A-5a31O:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Streptococcus
pyogenes) 		PF01597
(GCV_H) 		4 LEU A  50
LEU A  62
SER A  63
LEU A  43
 None
 1.15A 1ya3A-5a35A:
undetectable		 1ya3A-5a35A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 LEU D  58
LEU D  64
SER D  63
LEU D 112
 None
 1.06A 1ya3A-5a6bD:
undetectable		 1ya3A-5a6bD:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anc RIBOSOME MATURATION
PROTEIN SBDS

(Homo sapiens) 		PF01172
(SBDS)
PF09377
(SBDS_C) 		4 LEU J 174
LEU J 234
SER J 233
LEU J 178
 None
 0.99A 1ya3A-5ancJ:
undetectable		 1ya3A-5ancJ:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		4 LEU A 260
LEU A 321
SER A 320
LEU A 487
 None
 1.16A 1ya3A-5ck7A:
undetectable		 1ya3A-5ck7A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		4 LEU A  98
LEU A  80
SER A  81
LEU A 130
 None
 1.16A 1ya3A-5frsA:
undetectable		 1ya3A-5frsA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LEU B1037
LEU B1058
SER B1056
LEU B1030
 None
 1.06A 1ya3A-5ip9B:
undetectable		 1ya3A-5ip9B:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 LEU A 281
LEU A  69
SER A  70
LEU A 103
 None
 0.86A 1ya3A-5ksdA:
3.5		 1ya3A-5ksdA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 LEU A 371
LEU A 296
SER A 295
LEU A 383
 None
 1.10A 1ya3A-5l5gA:
undetectable		 1ya3A-5l5gA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 LEU A 976
LEU A1001
SER A1002
LEU A 984
 None
 1.15A 1ya3A-5me3A:
2.3		 1ya3A-5me3A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		4 LEU A1169
LEU A1625
SER A1626
LEU A1163
 None
None
EDO  A2011 ( 4.5A)
None
 1.09A 1ya3A-5mznA:
undetectable		 1ya3A-5mznA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION

(Mus musculus) 		no annotation 4 LEU B 269
LEU B 219
SER B 216
LEU B 276
 None
 1.18A 1ya3A-5oenB:
undetectable		 1ya3A-5oenB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION

(Mus musculus) 		no annotation 4 LEU B 307
LEU B 219
SER B 216
LEU B 276
 None
 1.02A 1ya3A-5oenB:
undetectable		 1ya3A-5oenB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A 455
LEU A 588
SER A 585
LEU A 462
 None
 1.13A 1ya3A-5ujaA:
undetectable		 1ya3A-5ujaA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		4 LEU A 520
LEU A 526
SER A 528
LEU A 536
 None
 1.06A 1ya3A-5wu6A:
undetectable		 1ya3A-5wu6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 4 LEU D 859
LEU D 889
SER D 893
LEU D 926
 None
 1.16A 1ya3A-5xbkD:
undetectable		 1ya3A-5xbkD:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqh PROTEIN ROGDI
HOMOLOG

(Homo sapiens) 		PF10259
(Rogdi_lz) 		4 LEU A  31
LEU A 267
SER A 264
LEU A  38
 None
 1.11A 1ya3A-5xqhA:
undetectable		 1ya3A-5xqhA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao3 GASDERMIN-D

(Mus musculus) 		no annotation 4 LEU A 315
LEU A 478
SER A 475
LEU A 381
 None
 1.02A 1ya3A-6ao3A:
undetectable		 1ya3A-6ao3A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 LEU A 455
LEU A 588
SER A 585
LEU A 462
 None
 1.10A 1ya3A-6bhuA:
undetectable		 1ya3A-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 LEU A1436
LEU A1443
SER A1401
LEU A1387
 None
 1.11A 1ya3A-6bhuA:
undetectable		 1ya3A-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjq -

(-) 		no annotation 4 LEU A  91
LEU A 100
SER A 105
LEU A  34
 None
None
None
PGW  A 505 ( 4.4A)
 1.18A 1ya3A-6cjqA:
undetectable		 1ya3A-6cjqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		no annotation 4 LEU D 642
LEU D 610
SER D 607
LEU D 587
 None
 1.13A 1ya3A-6d6vD:
undetectable		 1ya3A-6d6vD:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehn CARBOHYDRATE
ESTERASE MZ0003

(unidentified
prokaryotic
organism) 		no annotation 4 LEU A 315
LEU A 274
SER A 275
LEU A 308
 None
 1.14A 1ya3A-6ehnA:
undetectable		 1ya3A-6ehnA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 LEU A 289
LEU A 286
SER A 285
LEU A 312
 None
 1.17A 1ya3A-6f9nA:
undetectable		 1ya3A-6f9nA:
16.67