SIMILAR PATTERNS OF AMINO ACIDS FOR 1YA3_A_STRA1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ASN B 200
ALA B 230
LEU B 235
MET B 270
THR B 170
 KCX  B 219 ( 4.2A)
None
None
None
None
 1.38A 1ya3A-1e9yB:
undetectable		 1ya3A-1e9yB:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 349
ALA A 350
LEU A 391
ARG A 394
MET A 421
 EST  A   1 ( 4.8A)
EST  A   1 ( 3.7A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
 0.60A 1ya3A-1pcgA:
26.6		 1ya3A-1pcgA:
29.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 LEU A 208
ASN A 195
ALA A  27
GLN A  28
ARG A 246
 None
NAG  A 801 (-1.9A)
None
None
None
 1.46A 1ya3A-1rj6A:
undetectable		 1ya3A-1rj6A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ASN A 748
LEU A 745
ALA A 752
LEU A 499
MET A 359
 None
 1.15A 1ya3A-1rrhA:
undetectable		 1ya3A-1rrhA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 158
LEU A  71
ALA A  70
LEU A  14
THR A 126
 None
 1.43A 1ya3A-2ag1A:
undetectable		 1ya3A-2ag1A:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 701
ASN A 705
LEU A 707
GLN A 711
MET A 742
ARG A 752
MET A 780
MET A 787
 None
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-3.6A)
 0.74A 1ya3A-2ax9A:
34.8		 1ya3A-2ax9A:
51.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 LEU A 329
ASN A 326
LEU A 399
ALA A 360
THR A 313
 None
 1.30A 1ya3A-2b8nA:
undetectable		 1ya3A-2b8nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be4 HYPOTHETICAL PROTEIN
LOC449832

(Danio rerio) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 LEU A 167
LEU A 266
ALA A 263
LEU A 245
MET A 107
 None
 1.30A 1ya3A-2be4A:
undetectable		 1ya3A-2be4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 253
ASN A 271
LEU A 269
ALA A 298
ARG A  81
 None
 1.18A 1ya3A-2dpnA:
undetectable		 1ya3A-2dpnA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 265
LEU A 271
ALA A 272
MET A 306
ARG A 316
 None
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
 0.45A 1ya3A-2gpvA:
25.9		 1ya3A-2gpvA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL

(Arabidopsis
thaliana) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 393
LEU A 401
ALA A 376
MET A 333
CYH A 306
 None
 1.34A 1ya3A-2ix5A:
undetectable		 1ya3A-2ix5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		5 LEU A 790
LEU A 787
LEU A 809
MET A 693
THR A 716
 None
 1.38A 1ya3A-2oajA:
undetectable		 1ya3A-2oajA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 349
ALA A 350
LEU A 391
ARG A 394
MET A 421
 EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.58A 1ya3A-2ocfA:
27.8		 1ya3A-2ocfA:
28.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  28
LEU A  35
GLN A  39
LEU A  77
ARG A  80
 None
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
 1.14A 1ya3A-2q3yA:
36.9		 1ya3A-2q3yA:
72.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		12 LEU A  29
ASN A  33
LEU A  35
ALA A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
MET A 115
CYH A 205
THR A 208
 1CA  A 247 ( 3.6A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
1CA  A 247 ( 3.7A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
 0.48A 1ya3A-2q3yA:
36.9		 1ya3A-2q3yA:
72.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ras TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Novosphingobium
aromaticivorans) 		PF00440
(TetR_N) 		5 LEU A 134
ASN A 160
LEU A 158
MET A  87
CYH A 167
 None
EDO  A 216 ( 4.0A)
None
None
EDO  A 216 (-4.3A)
 1.41A 1ya3A-2rasA:
undetectable		 1ya3A-2rasA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  65
LEU A  91
ALA A  58
LEU A  86
MET A  80
 None
 1.27A 1ya3A-2v7bA:
undetectable		 1ya3A-2v7bA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqe MUTS2 PROTEIN

(Thermus
thermophilus) 		PF01713
(Smr) 		5 LEU A  54
ALA A  23
GLN A  22
LEU A  18
THR A  76
 None
 1.48A 1ya3A-2zqeA:
undetectable		 1ya3A-2zqeA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		5 ALA A 361
GLN A 362
MET A 460
CYH A 431
THR A 435
 None
 1.38A 1ya3A-3a9sA:
undetectable		 1ya3A-3a9sA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 LEU A 348
LEU A 532
MET A 506
LEU A 523
THR A 352
 None
 1.45A 1ya3A-3djlA:
undetectable		 1ya3A-3djlA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Burkholderia
pseudomallei) 		PF14681
(UPRTase) 		5 LEU A 164
ALA A 168
LEU A 204
ARG A  26
MET A  90
 None
 1.21A 1ya3A-3dmpA:
undetectable		 1ya3A-3dmpA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		5 ASN A 279
LEU A 448
ALA A 449
GLN A 452
THR A 318
 None
None
None
None
ZN  A 601 ( 4.3A)
 1.17A 1ya3A-3e2dA:
undetectable		 1ya3A-3e2dA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale) 		PF00266
(Aminotran_5) 		5 ALA A 168
LEU A 189
ARG A 247
MET A 181
THR A 144
 None
None
None
None
GOL  A 360 (-2.8A)
 1.47A 1ya3A-3f0hA:
undetectable		 1ya3A-3f0hA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A 202
ALA A 526
GLN A 525
LEU A 468
MET A 491
 None
 1.49A 1ya3A-3gmeA:
undetectable		 1ya3A-3gmeA:
17.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 714
GLN A 725
LEU A 763
ARG A 766
MET A 801
 None
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
 1.36A 1ya3A-3kbaA:
35.2		 1ya3A-3kbaA:
54.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 715
ASN A 719
LEU A 721
MET A 756
LEU A 763
ARG A 766
MET A 801
CYH A 891
THR A 894
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
 0.58A 1ya3A-3kbaA:
35.2		 1ya3A-3kbaA:
54.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 721
GLN A 725
MET A 756
LEU A 763
ARG A 766
MET A 801
CYH A 891
THR A 894
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
 0.78A 1ya3A-3kbaA:
35.2		 1ya3A-3kbaA:
54.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11

(Homo sapiens) 		PF00621
(RhoGEF) 		5 LEU A 775
LEU A 842
ALA A 839
MET A 764
MET A 857
 None
 1.01A 1ya3A-3kz1A:
undetectable		 1ya3A-3kz1A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 LEU X 195
LEU X  88
ALA X 200
LEU X 376
THR X 122
 None
 1.50A 1ya3A-3pb9X:
undetectable		 1ya3A-3pb9X:
23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 LEU A  28
LEU A  35
GLN A  39
LEU A  77
ARG A  80
 None
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
 1.15A 1ya3A-3ry9A:
36.3		 1ya3A-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		11 LEU A  29
ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
MET A 115
CYH A 205
THR A 208
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.42A 1ya3A-3ry9A:
36.3		 1ya3A-3ry9A:
69.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sh5 LG3 PEPTIDE

(Homo sapiens) 		PF00054
(Laminin_G_1) 		5 LEU A  46
LEU A  16
ALA A  17
LEU A 163
THR A 148
 None
 1.47A 1ya3A-3sh5A:
undetectable		 1ya3A-3sh5A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 235
LEU A 280
ALA A 277
LEU A 285
THR A 317
 None
 1.42A 1ya3A-3sheA:
undetectable		 1ya3A-3sheA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u24 PUTATIVE LIPOPROTEIN

(Shewanella
oneidensis) 		PF05960
(DUF885) 		5 LEU A 241
ASN A 195
LEU A 193
LEU A 535
ARG A 531
 None
 1.16A 1ya3A-3u24A:
undetectable		 1ya3A-3u24A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A

(Schizosaccharomyces
pombe) 		PF08662
(eIF2A) 		5 LEU A  17
ASN A  19
ALA A  20
LEU A 369
THR A  62
 None
 1.29A 1ya3A-3wj9A:
undetectable		 1ya3A-3wj9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		5 LEU A 359
ASN A 431
LEU A 433
ALA A 430
LEU A 400
 None
 1.41A 1ya3A-3zbmA:
undetectable		 1ya3A-3zbmA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		5 LEU A 177
ASN A 180
ALA A 183
MET A   1
LEU A 392
 GOL  A1404 (-3.7A)
None
None
None
None
 1.46A 1ya3A-3zlbA:
undetectable		 1ya3A-3zlbA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		5 LEU A 357
ALA A 358
LEU A 263
ARG A 193
THR A 369
 None
None
FAD  A1509 (-4.4A)
None
None
 1.35A 1ya3A-3zxsA:
undetectable		 1ya3A-3zxsA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA

(Salmonella
enterica) 		PF03193
(RsgA_GTPase) 		5 LEU V 243
ASN V 233
LEU V 231
ALA V 234
LEU V 213
 None
 1.31A 1ya3A-4a2iV:
undetectable		 1ya3A-4a2iV:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am9 CHAPERONE SYCD

(Yersinia
enterocolitica) 		PF07720
(TPR_3) 		5 LEU A  36
LEU A  42
ALA A  43
GLN A  46
CYH A  63
 None
 0.84A 1ya3A-4am9A:
undetectable		 1ya3A-4am9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		5 LEU A  74
ALA B 308
MET B 333
LEU B 313
THR B 433
 None
NAG  A3020 ( 4.0A)
S35  A1259 ( 3.9A)
None
None
 1.35A 1ya3A-4az3A:
undetectable		 1ya3A-4az3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 324
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.19A 1ya3A-4fdhA:
undetectable		 1ya3A-4fdhA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		5 LEU A  59
LEU A  62
ALA A  98
LEU A 132
THR A 117
 None
C8E  A 502 ( 4.3A)
C8E  A 502 ( 3.8A)
None
None
 1.31A 1ya3A-4frxA:
undetectable		 1ya3A-4frxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5t INTERFERON-ACTIVABLE
PROTEIN 202

(Mus musculus) 		PF02760
(HIN) 		5 LEU A 367
LEU A 324
ALA A 325
MET A 281
THR A 433
 None
 1.48A 1ya3A-4l5tA:
undetectable		 1ya3A-4l5tA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 280
LEU A 286
ALA A 287
MET A 321
ARG A 331
MET A 358
 None
 0.68A 1ya3A-4n1yA:
28.3		 1ya3A-4n1yA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A 201
ALA A 529
GLN A 528
LEU A 471
MET A 494
 None
 1.41A 1ya3A-4nbqA:
undetectable		 1ya3A-4nbqA:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ASN A 564
LEU A 566
GLN A 570
MET A 601
LEU A 608
ARG A 611
MET A 646
CYH A 736
THR A 739
 MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
 0.66A 1ya3A-4p6wA:
33.9		 1ya3A-4p6wA:
56.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		5 LEU A 113
MET A  85
LEU A 137
CYH A  61
THR A  59
 None
 1.49A 1ya3A-4qfeA:
undetectable		 1ya3A-4qfeA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 766
ASN A 770
LEU A 772
ALA A 773
GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
CYH A 942
THR A 945
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
 0.37A 1ya3A-4udbA:
37.2		 1ya3A-4udbA:
91.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynq THREE-PRIME REPAIR
EXONUCLEASE 1

(Mus musculus) 		no annotation 5 LEU A 121
LEU A  37
ALA A  38
LEU A  44
THR A 150
 None
 1.41A 1ya3A-4ynqA:
undetectable		 1ya3A-4ynqA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 163
LEU A  71
ALA A  70
LEU A  11
THR A 131
 None
 1.38A 1ya3A-5ahkA:
undetectable		 1ya3A-5ahkA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		5 LEU A 351
ASN A 348
LEU A 344
ALA A 345
LEU A 302
 None
 1.40A 1ya3A-5h7dA:
undetectable		 1ya3A-5h7dA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 LEU A 659
ALA A 576
MET A 602
LEU A 644
CYH A 628
 None
 1.42A 1ya3A-5hy7A:
undetectable		 1ya3A-5hy7A:
12.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 765
LEU A 772
GLN A 776
LEU A 814
ARG A 817
 None
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
 1.11A 1ya3A-5mwpA:
38.0		 1ya3A-5mwpA:
73.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 11 LEU A 766
ASN A 770
LEU A 772
ALA A 773
GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 845
CYH A 942
THR A 945
 ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
 0.41A 1ya3A-5mwpA:
38.0		 1ya3A-5mwpA:
73.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 766
ASN A 770
LEU A 827
CYH A 942
THR A 945
 ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
 1.32A 1ya3A-5mwpA:
38.0		 1ya3A-5mwpA:
73.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 8 LEU A 772
ALA A 773
GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
CYH A 942
 ECV  A1101 ( 3.9A)
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 (-4.0A)
 0.77A 1ya3A-5mwpA:
38.0		 1ya3A-5mwpA:
73.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 ASN A 369
LEU A 367
ALA A 366
LEU A 292
MET A 222
 8R5  A 502 (-3.4A)
None
None
None
None
 1.20A 1ya3A-5nagA:
undetectable		 1ya3A-5nagA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nci LEUCINE HYDROXYLASE

(Streptomyces
muensis) 		PF05721
(PhyH) 		5 LEU A 223
ASN A  97
LEU A  58
ALA A  57
ARG A  64
 AKG  A 302 ( 4.8A)
AKG  A 302 (-3.3A)
None
None
None
 1.39A 1ya3A-5nciA:
undetectable		 1ya3A-5nciA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 301
ALA A 302
MET A 336
LEU A 343
ARG A 346
 EST  A 601 ( 4.3A)
EST  A 601 ( 3.9A)
EST  A 601 ( 3.7A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
 0.39A 1ya3A-5toaA:
25.1		 1ya3A-5toaA:
29.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 ASN A 560
LEU A 562
GLN A 566
MET A 597
LEU A 604
ARG A 607
MET A 642
 486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.77A 1ya3A-5uc1A:
22.1		 1ya3A-5uc1A:
56.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 LEU A 562
GLN A 566
LEU A 604
ARG A 607
MET A 635
 486  A 801 ( 4.8A)
486  A 801 (-2.8A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
 1.09A 1ya3A-5uc1A:
22.1		 1ya3A-5uc1A:
56.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		8 ASN A  33
LEU A  35
GLN A  39
LEU A  77
ARG A  80
MET A 108
MET A 115
THR A 208
 1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.0A)
 1.01A 1ya3A-5ufsA:
35.5		 1ya3A-5ufsA:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		9 ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
CYH A 205
THR A 208
 1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
 0.46A 1ya3A-5ufsA:
35.5		 1ya3A-5ufsA:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 LEU A  28
LEU A  35
GLN A  39
LEU A  77
ARG A  80
MET A 108
MET A 115
 None
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
1TA  A 301 ( 2.8A)
 1.44A 1ya3A-5ufsA:
35.5		 1ya3A-5ufsA:
62.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhd RNA POLYMERASE SIGMA
FACTOR SIGA

(Mycobacterium
tuberculosis) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		5 LEU F 257
LEU F 249
ALA F 291
LEU F 296
THR F 260
 None
 1.29A 1ya3A-5uhdF:
undetectable		 1ya3A-5uhdF:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 5 LEU A 111
ASN A  77
ALA A  72
LEU A  65
MET A  29
 None
 1.43A 1ya3A-5xnzA:
undetectable		 1ya3A-5xnzA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY

(uncultured
archaeon
MedDCM-OCT-S05-C57) 		no annotation 5 LEU A 204
LEU A 166
GLN A  10
LEU A  73
THR A 202
 None
NAD  A 402 (-3.8A)
NAD  A 402 (-3.8A)
AKB  A 401 (-4.1A)
None
 1.43A 1ya3A-5y1gA:
undetectable		 1ya3A-5y1gA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y96 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR1

(Arabidopsis
thaliana) 		no annotation 5 LEU B 389
ASN B 390
LEU B 252
GLN B 315
MET B 374
 None
 1.45A 1ya3A-5y96B:
undetectable		 1ya3A-5y96B:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 5 LEU A 364
LEU A 279
ALA A 318
LEU A 325
CYH A 419
 None
 1.36A 1ya3A-6cc4A:
undetectable		 1ya3A-6cc4A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6el8 FORKHEAD BOX PROTEIN
N1

(Homo sapiens) 		no annotation 5 LEU A 322
ASN A 321
LEU A 278
MET A 354
CYH A 327
 None
 1.30A 1ya3A-6el8A:
undetectable		 1ya3A-6el8A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 LEU A1627
ASN A1631
LEU A1633
LEU A1611
THR A1774
 None
 1.28A 1ya3A-6ez8A:
undetectable		 1ya3A-6ez8A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv4 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		no annotation 5 LEU A 126
LEU A 138
ALA A  95
LEU A 284
THR A 162
 None
 1.18A 1ya3A-6fv4A:
undetectable		 1ya3A-6fv4A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdt -

(-) 		no annotation 5 LEU A   2
LEU A 482
ALA A  18
GLN A  17
THR A  83
 None
 1.39A 1ya3A-6gdtA:
undetectable		 1ya3A-6gdtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0p SITE-SPECIFIC
RECOMBINASE XERD

(Escherichia
coli) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		4 LEU A  40
LEU A  33
SER A  34
LEU A   5
 None
 1.18A 1ya3A-1a0pA:
0.2		 1ya3A-1a0pA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 246
LEU A 169
SER A 170
LEU A  60
 None
 1.17A 1ya3A-1ciyA:
0.8		 1ya3A-1ciyA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyd CARBONYL REDUCTASE

(Mus musculus) 		PF13561
(adh_short_C2) 		4 LEU A   8
LEU A 223
SER A 224
LEU A   3
 None
 1.16A 1ya3A-1cydA:
undetectable		 1ya3A-1cydA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dc1 BSOBI RESTRICTION
ENDONUCLEASE

(Geobacillus
stearothermophilus) 		PF09194
(Endonuc-BsobI) 		4 LEU A  63
LEU A  98
SER A  94
LEU A  73
 None
None
DIO  A1008 (-3.3A)
None
 1.11A 1ya3A-1dc1A:
0.0		 1ya3A-1dc1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izm HYPOTHETICAL PROTEIN
HI0817

(Haemophilus
influenzae) 		PF03695
(UPF0149) 		4 LEU A  36
LEU A  28
SER A  29
LEU A  74
 None
 1.12A 1ya3A-1izmA:
undetectable		 1ya3A-1izmA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwe PROTEIN (DNAB
HELICASE)

(Escherichia
coli) 		PF00772
(DnaB) 		4 LEU A  83
LEU A  90
SER A  89
LEU A  74
 None
 1.18A 1ya3A-1jweA:
0.0		 1ya3A-1jweA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 LEU A 510
LEU A 505
SER A 502
LEU A 453
 None
 1.10A 1ya3A-1qgrA:
0.0		 1ya3A-1qgrA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzg PROTECTION OF
TELOMERES PROTEIN 1

(Schizosaccharomyces
pombe) 		PF02765
(POT1) 		4 LEU A  83
LEU A 122
SER A 123
LEU A  87
 None
 1.04A 1ya3A-1qzgA:
undetectable		 1ya3A-1qzgA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1skx ORPHAN NUCLEAR
RECEPTOR PXR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 154
LEU A 348
SER A 347
LEU A 286
 None
 0.91A 1ya3A-1skxA:
19.6		 1ya3A-1skxA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		4 LEU A 419
LEU A 378
SER A 401
LEU A 408
 None
 1.06A 1ya3A-1ytmA:
undetectable		 1ya3A-1ytmA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C

(Wolinella
succinogenes) 		PF01127
(Sdh_cyt) 		4 LEU C 225
LEU C 220
SER C 217
LEU C 181
 None
 1.01A 1ya3A-2bs4C:
0.0		 1ya3A-2bs4C:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		4 LEU A 214
LEU A 175
SER A 173
LEU A 221
 None
 1.17A 1ya3A-2g02A:
undetectable		 1ya3A-2g02A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g40 CONSERVED
HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02589
(LUD_dom) 		4 LEU A 117
LEU A 143
SER A 144
LEU A 132
 None
 0.96A 1ya3A-2g40A:
undetectable		 1ya3A-2g40A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gop TRILOBED PROTEASE

(Pyrococcus
furiosus) 		PF07676
(PD40) 		4 LEU A 101
LEU A 109
SER A 108
LEU A 119
 None
 1.17A 1ya3A-2gopA:
undetectable		 1ya3A-2gopA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5r MSTRAWBERRY

(Discosoma sp.) 		PF01353
(GFP) 		4 LEU A 189
LEU A  85
SER A  86
LEU A  83
 None
 1.03A 1ya3A-2h5rA:
undetectable		 1ya3A-2h5rA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		4 LEU A 249
LEU A 236
SER A 237
LEU A 352
 None
 1.12A 1ya3A-2hb6A:
undetectable		 1ya3A-2hb6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 276
LEU A 306
SER A 307
LEU A 289
 None
 1.10A 1ya3A-2i6tA:
undetectable		 1ya3A-2i6tA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pby GLUTAMINASE

(Geobacillus
kaustophilus) 		PF04960
(Glutaminase) 		4 LEU A 145
LEU A  63
SER A  67
LEU A 138
 None
 1.19A 1ya3A-2pbyA:
undetectable		 1ya3A-2pbyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		4 LEU A 510
LEU A 505
SER A 502
LEU A 453
 None
 0.96A 1ya3A-2qnaA:
undetectable		 1ya3A-2qnaA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsv UNCHARACTERIZED
PROTEIN

(Porphyromonas
gingivalis) 		PF07610
(DUF1573) 		4 LEU A 178
LEU A 122
SER A 123
LEU A 126
 None
 1.13A 1ya3A-2qsvA:
undetectable		 1ya3A-2qsvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 LEU A 121
LEU A  17
SER A  18
LEU A  60
 None
 0.94A 1ya3A-2rgjA:
undetectable		 1ya3A-2rgjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25

(Homo sapiens) 		PF00621
(RhoGEF) 		4 LEU B 222
LEU B 168
SER B 166
LEU B 229
 None
 1.06A 1ya3A-2rgnB:
undetectable		 1ya3A-2rgnB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wam CONSERVED
HYPOTHETICAL ALANINE
AND LEUCINE RICH
PROTEIN

(Mycobacterium
tuberculosis) 		PF09754
(PAC2) 		4 LEU A 108
LEU A 105
SER A 104
LEU A  69
 None
 1.16A 1ya3A-2wamA:
undetectable		 1ya3A-2wamA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb7 PT26-6P

(Thermococcus
sp. 26-2) 		no annotation 4 LEU A 388
LEU A 393
SER A 394
LEU A 391
 None
 1.16A 1ya3A-2wb7A:
undetectable		 1ya3A-2wb7A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 LEU A 505
LEU A 484
SER A 480
LEU A 461
 None
 1.10A 1ya3A-2xdfA:
undetectable		 1ya3A-2xdfA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xes PROTEIN PAT1 HOMOLOG
1

(Homo sapiens) 		PF09770
(PAT1) 		4 LEU A 601
LEU A 642
SER A 641
LEU A 637
 None
 1.13A 1ya3A-2xesA:
undetectable		 1ya3A-2xesA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		4 LEU A 148
LEU A  35
SER A  36
LEU A 154
 BR  A1302 ( 4.9A)
None
None
None
 0.95A 1ya3A-2ykfA:
undetectable		 1ya3A-2ykfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 LEU A 233
LEU A  26
SER A  27
LEU A  80
 None
 1.11A 1ya3A-2z5xA:
undetectable		 1ya3A-2z5xA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU B 129
LEU B 121
SER B 122
LEU B 168
 None
 1.11A 1ya3A-2z7xB:
undetectable		 1ya3A-2z7xB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU B 136
LEU B 128
SER B 129
LEU B 175
 None
 0.97A 1ya3A-3a79B:
undetectable		 1ya3A-3a79B:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 112
LEU A  84
SER A  83
LEU A 335
 None
 0.95A 1ya3A-3bn1A:
undetectable		 1ya3A-3bn1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btz ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 2

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		4 LEU A  72
LEU A 251
SER A 186
LEU A 218
 None
 0.90A 1ya3A-3btzA:
undetectable		 1ya3A-3btzA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbg O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF01596
(Methyltransf_3) 		4 LEU A  82
LEU A  76
SER A  74
LEU A  52
 None
None
SAH  A 301 (-2.9A)
None
 1.17A 1ya3A-3cbgA:
undetectable		 1ya3A-3cbgA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 GAMMA
CHAIN

(Escherichia
coli) 		PF02665
(Nitrate_red_gam) 		4 LEU C 102
LEU C 133
SER C 131
LEU C 109
 None
HEM  C 806 ( 4.8A)
None
None
 1.06A 1ya3A-3egwC:
undetectable		 1ya3A-3egwC:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h75 PERIPLASMIC
SUGAR-BINDING DOMAIN
PROTEIN

(Pseudomonas
protegens) 		PF13407
(Peripla_BP_4) 		4 LEU A 104
LEU A 129
SER A 130
LEU A 137
 None
 1.19A 1ya3A-3h75A:
undetectable		 1ya3A-3h75A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3him PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 LEU A  63
LEU A  69
SER A  68
LEU A 121
 None
 1.15A 1ya3A-3himA:
undetectable		 1ya3A-3himA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwe MGLL PROTEIN

(Homo sapiens) 		PF12146
(Hydrolase_4) 		4 LEU A 271
LEU A 154
SER A 156
LEU A 281
 None
 0.99A 1ya3A-3jweA:
undetectable		 1ya3A-3jweA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k12 UNCHARACTERIZED
PROTEIN A6V7T0

(Pseudomonas
aeruginosa) 		PF01042
(Ribonuc_L-PSP) 		4 LEU A  79
LEU A  99
SER A  98
LEU A  69
 None
 1.11A 1ya3A-3k12A:
undetectable		 1ya3A-3k12A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p PROTEIN TRANSPORT
PROTEIN SEC39

(Saccharomyces
cerevisiae) 		PF08314
(Sec39) 		4 LEU D 385
LEU D 362
SER D 360
LEU D 356
 None
 1.01A 1ya3A-3k8pD:
undetectable		 1ya3A-3k8pD:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m88 AMOEBIASIN-2

(Entamoeba
histolytica) 		PF09394
(Inhibitor_I42) 		4 LEU A  91
LEU A  63
SER A  64
LEU A  37
 None
 1.18A 1ya3A-3m88A:
undetectable		 1ya3A-3m88A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meb ASPARTATE
AMINOTRANSFERASE

(Giardia
intestinalis) 		PF00155
(Aminotran_1_2) 		4 LEU A 365
LEU A 347
SER A 346
LEU A 342
 None
 1.14A 1ya3A-3mebA:
undetectable		 1ya3A-3mebA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncc PROLACTIN

(Homo sapiens) 		PF00103
(Hormone_1) 		4 LEU A 127
LEU A  25
SER A  26
LEU A 186
 None
 1.12A 1ya3A-3nccA:
undetectable		 1ya3A-3nccA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		4 LEU A 175
LEU A 170
SER A 167
LEU A 184
 None
 1.18A 1ya3A-3o75A:
undetectable		 1ya3A-3o75A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 LEU A 362
LEU A 392
SER A 393
LEU A  52
 None
 1.14A 1ya3A-3tk3A:
2.3		 1ya3A-3tk3A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukm POTASSIUM CHANNEL
SUBFAMILY K MEMBER 1

(Homo sapiens) 		PF07885
(Ion_trans_2) 		4 LEU A 146
LEU A 115
SER A 116
LEU A 257
 None
 1.06A 1ya3A-3ukmA:
undetectable		 1ya3A-3ukmA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uoe DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02615
(Ldh_2) 		4 LEU A  52
LEU A  15
SER A  12
LEU A  46
 None
 1.13A 1ya3A-3uoeA:
undetectable		 1ya3A-3uoeA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 LEU A 376
LEU A 480
SER A 476
LEU A 383
 None
 1.01A 1ya3A-3w9hA:
undetectable		 1ya3A-3w9hA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		4 LEU A 309
LEU A 297
SER A 294
LEU A 327
 None
 1.07A 1ya3A-3wqyA:
0.4		 1ya3A-3wqyA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxe GALECTIN-7

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 LEU A  37
LEU A  48
SER A  63
LEU A 113
 None
 1.12A 1ya3A-3zxeA:
undetectable		 1ya3A-3zxeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 LEU A 546
LEU A 480
SER A 478
LEU A 553
 None
 1.15A 1ya3A-4a2wA:
undetectable		 1ya3A-4a2wA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 246
LEU A 169
SER A 170
LEU A  60
 None
 1.18A 1ya3A-4arxA:
undetectable		 1ya3A-4arxA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayi LIPOPROTEIN GNA1870
CCOMPND 7

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		4 LEU D 133
LEU D  99
SER D 127
LEU D  89
 None
 1.18A 1ya3A-4ayiD:
undetectable		 1ya3A-4ayiD:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		4 LEU A 158
LEU A 203
SER A 204
LEU A 197
 None
IMD  A1342 ( 4.8A)
None
None
 1.17A 1ya3A-4bf7A:
undetectable		 1ya3A-4bf7A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL

(Homo sapiens) 		PF07992
(Pyr_redox_2)
PF14721
(AIF_C) 		4 LEU A 293
LEU A 175
SER A 176
LEU A 311
 None
FAD  A1449 ( 4.7A)
FAD  A1449 (-3.6A)
FAD  A1449 ( 4.7A)
 1.13A 1ya3A-4bv6A:
undetectable		 1ya3A-4bv6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c76 FMN REDUCTASE
(NADPH)

(Pseudomonas
putida) 		PF03358
(FMN_red) 		4 LEU A 100
LEU A  49
SER A  50
LEU A  93
 None
 1.13A 1ya3A-4c76A:
undetectable		 1ya3A-4c76A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		4 LEU A 196
LEU A 189
SER A 190
LEU A 228
 None
 1.09A 1ya3A-4cemA:
undetectable		 1ya3A-4cemA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 LEU B 139
LEU B 147
SER B 146
LEU B 117
 None
 1.06A 1ya3A-4htfB:
undetectable		 1ya3A-4htfB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
fluorescens) 		PF04909
(Amidohydro_2) 		4 LEU A 204
LEU A 211
SER A 212
LEU A 209
 None
 1.09A 1ya3A-4ifrA:
undetectable		 1ya3A-4ifrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		4 LEU A1226
LEU A1055
SER A1056
LEU A1115
 None
 1.11A 1ya3A-4kegA:
undetectable		 1ya3A-4kegA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11

(synthetic
construct) 		PF01353
(GFP) 		4 LEU C 229
LEU C  85
SER C  86
LEU C  83
 None
 0.96A 1ya3A-4kf5C:
undetectable		 1ya3A-4kf5C:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll1 THIOREDOXIN-INTERACT
ING PROTEIN

(Homo sapiens) 		PF00339
(Arrestin_N)
PF02752
(Arrestin_C) 		4 LEU A 234
LEU A 294
SER A 275
LEU A 277
 None
 1.14A 1ya3A-4ll1A:
undetectable		 1ya3A-4ll1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		4 LEU A 361
LEU A 249
SER A 245
LEU A 354
 None
 1.12A 1ya3A-4mm0A:
undetectable		 1ya3A-4mm0A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1)
PF16842
(RRM_occluded) 		4 LEU A 313
LEU A 316
SER A 384
LEU A 369
 None
 1.17A 1ya3A-4n0tA:
undetectable		 1ya3A-4n0tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 LEU A 373
LEU A 301
SER A 298
LEU A 350
 None
 1.13A 1ya3A-4pv4A:
undetectable		 1ya3A-4pv4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0y UNCHARACTERIZED
PROTEIN

(Clostridium
sporogenes) 		no annotation 4 LEU A 120
LEU A 123
SER A 131
LEU A 152
 None
 0.97A 1ya3A-4q0yA:
undetectable		 1ya3A-4q0yA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		4 LEU A 389
LEU A  24
SER A  25
LEU A 413
 None
 1.19A 1ya3A-4q22A:
undetectable		 1ya3A-4q22A:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 769
LEU A 810
SER A 811
LEU A 938
 CV7  A1987 (-4.1A)
CV7  A1987 (-4.0A)
None
CV7  A1987 ( 3.9A)
 0.41A 1ya3A-4udbA:
37.2		 1ya3A-4udbA:
91.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		4 LEU A 422
LEU A 461
SER A 459
LEU A 456
 None
 1.17A 1ya3A-4uvkA:
undetectable		 1ya3A-4uvkA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxd 2-DEHYDRO-3-DEOXY-D-
GLUCONATE/2-DEHYDRO-
3-DEOXY-PHOSPHOGLUCO
NATE ALDOLASE

(Picrophilus
torridus) 		PF00701
(DHDPS) 		4 LEU A 226
LEU A 193
SER A 192
LEU A 188
 None
 1.13A 1ya3A-4uxdA:
undetectable		 1ya3A-4uxdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 246
LEU A 169
SER A 170
LEU A  60
 None
 1.13A 1ya3A-4w8jA:
undetectable		 1ya3A-4w8jA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfq SUPPRESSOR OF
STEM-LOOP PROTEIN 1

(Saccharomyces
cerevisiae) 		PF04056
(Ssl1) 		4 LEU A 300
LEU A 266
SER A 267
LEU A 292
 None
 1.15A 1ya3A-4wfqA:
undetectable		 1ya3A-4wfqA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x68 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00144
(Beta-lactamase) 		4 LEU A 384
LEU A  60
SER A  59
LEU A 266
 None
 0.95A 1ya3A-4x68A:
undetectable		 1ya3A-4x68A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Saccharomyces
cerevisiae) 		PF12569
(NARP1) 		4 LEU A 368
LEU A 363
SER A 360
LEU A 397
 None
 1.19A 1ya3A-4xpdA:
undetectable		 1ya3A-4xpdA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtl SODIUM PUMPING
RHODOPSIN

(Dokdonia
eikasta) 		PF01036
(Bac_rhodopsin) 		4 LEU A 121
LEU A  63
SER A  64
LEU A 262
 None
None
LYR  A 255 ( 4.9A)
None
 1.08A 1ya3A-4xtlA:
undetectable		 1ya3A-4xtlA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhb IRON-CHELATOR
UTILIZATION PROTEIN

(Thermobifida
fusca) 		PF04954
(SIP)
PF08021
(FAD_binding_9) 		4 LEU A  56
LEU A 129
SER A  17
LEU A  68
 None
None
None
MPD  A 303 (-4.6A)
 1.09A 1ya3A-4yhbA:
undetectable		 1ya3A-4yhbA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 LEU A2056
LEU A1932
SER A1931
LEU A1927
 None
 1.14A 1ya3A-5a22A:
undetectable		 1ya3A-5a22A:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12862
(ANAPC5) 		4 LEU O 402
LEU O 384
SER O 383
LEU O 379
 None
 1.03A 1ya3A-5a31O:
undetectable		 1ya3A-5a31O:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a35 GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Streptococcus
pyogenes) 		PF01597
(GCV_H) 		4 LEU A  50
LEU A  62
SER A  63
LEU A  43
 None
 1.15A 1ya3A-5a35A:
undetectable		 1ya3A-5a35A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 LEU D  58
LEU D  64
SER D  63
LEU D 112
 None
 1.06A 1ya3A-5a6bD:
undetectable		 1ya3A-5a6bD:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anc RIBOSOME MATURATION
PROTEIN SBDS

(Homo sapiens) 		PF01172
(SBDS)
PF09377
(SBDS_C) 		4 LEU J 174
LEU J 234
SER J 233
LEU J 178
 None
 0.99A 1ya3A-5ancJ:
undetectable		 1ya3A-5ancJ:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		4 LEU A 260
LEU A 321
SER A 320
LEU A 487
 None
 1.16A 1ya3A-5ck7A:
undetectable		 1ya3A-5ck7A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		4 LEU A  98
LEU A  80
SER A  81
LEU A 130
 None
 1.16A 1ya3A-5frsA:
undetectable		 1ya3A-5frsA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LEU B1037
LEU B1058
SER B1056
LEU B1030
 None
 1.06A 1ya3A-5ip9B:
undetectable		 1ya3A-5ip9B:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 LEU A 281
LEU A  69
SER A  70
LEU A 103
 None
 0.86A 1ya3A-5ksdA:
3.5		 1ya3A-5ksdA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 LEU A 371
LEU A 296
SER A 295
LEU A 383
 None
 1.10A 1ya3A-5l5gA:
undetectable		 1ya3A-5l5gA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 LEU A 976
LEU A1001
SER A1002
LEU A 984
 None
 1.15A 1ya3A-5me3A:
2.3		 1ya3A-5me3A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzn HELICASE
SEN1,HELICASE SEN1

(Saccharomyces
cerevisiae) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		4 LEU A1169
LEU A1625
SER A1626
LEU A1163
 None
None
EDO  A2011 ( 4.5A)
None
 1.09A 1ya3A-5mznA:
undetectable		 1ya3A-5mznA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION

(Mus musculus) 		no annotation 4 LEU B 269
LEU B 219
SER B 216
LEU B 276
 None
 1.18A 1ya3A-5oenB:
undetectable		 1ya3A-5oenB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION

(Mus musculus) 		no annotation 4 LEU B 307
LEU B 219
SER B 216
LEU B 276
 None
 1.02A 1ya3A-5oenB:
undetectable		 1ya3A-5oenB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A 455
LEU A 588
SER A 585
LEU A 462
 None
 1.13A 1ya3A-5ujaA:
undetectable		 1ya3A-5ujaA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		4 LEU A 520
LEU A 526
SER A 528
LEU A 536
 None
 1.06A 1ya3A-5wu6A:
undetectable		 1ya3A-5wu6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 4 LEU D 859
LEU D 889
SER D 893
LEU D 926
 None
 1.16A 1ya3A-5xbkD:
undetectable		 1ya3A-5xbkD:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqh PROTEIN ROGDI
HOMOLOG

(Homo sapiens) 		PF10259
(Rogdi_lz) 		4 LEU A  31
LEU A 267
SER A 264
LEU A  38
 None
 1.11A 1ya3A-5xqhA:
undetectable		 1ya3A-5xqhA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao3 GASDERMIN-D

(Mus musculus) 		no annotation 4 LEU A 315
LEU A 478
SER A 475
LEU A 381
 None
 1.02A 1ya3A-6ao3A:
undetectable		 1ya3A-6ao3A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 LEU A 455
LEU A 588
SER A 585
LEU A 462
 None
 1.10A 1ya3A-6bhuA:
undetectable		 1ya3A-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 LEU A1436
LEU A1443
SER A1401
LEU A1387
 None
 1.11A 1ya3A-6bhuA:
undetectable		 1ya3A-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjq -

(-) 		no annotation 4 LEU A  91
LEU A 100
SER A 105
LEU A  34
 None
None
None
PGW  A 505 ( 4.4A)
 1.18A 1ya3A-6cjqA:
undetectable		 1ya3A-6cjqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		no annotation 4 LEU D 642
LEU D 610
SER D 607
LEU D 587
 None
 1.13A 1ya3A-6d6vD:
undetectable		 1ya3A-6d6vD:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehn CARBOHYDRATE
ESTERASE MZ0003

(unidentified
prokaryotic
organism) 		no annotation 4 LEU A 315
LEU A 274
SER A 275
LEU A 308
 None
 1.14A 1ya3A-6ehnA:
undetectable		 1ya3A-6ehnA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 LEU A 289
LEU A 286
SER A 285
LEU A 312
 None
 1.17A 1ya3A-6f9nA:
undetectable		 1ya3A-6f9nA:
16.67