SIMILAR PATTERNS OF AMINO ACIDS FOR 1Y93_A_HAEA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 800 (-3.2A)
ZN  A 800 ( 4.7A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.3A)
 0.22A 1y93A-1budA:
11.0		 1y93A-1budA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ck7 PROTEIN (GELATINASE
A)

(Homo sapiens) 		PF00040
(fn2)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 991 ( 3.1A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
 0.43A 1y93A-1ck7A:
27.8		 1y93A-1ck7A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eak 72 KDA TYPE IV
COLLAGENASE

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 996 (-3.1A)
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
 0.44A 1y93A-1eakA:
28.0		 1y93A-1eakA:
26.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)

(Sus scrofa) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		5 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 997 (-3.2A)
ZN  A 998 ( 3.5A)
HTA  A 900 (-3.0A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.43A 1y93A-1fblA:
27.7		 1y93A-1fblA:
37.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 HIS P 169
GLU P 170
HIS P 173
HIS P 179
 ZN  P 600 (-3.4A)
ZN  P 600 ( 4.0A)
ZN  P 600 (-3.4A)
ZN  P 600 (-3.4A)
 0.33A 1y93A-1h71P:
12.7		 1y93A-1h71P:
17.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfs STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.51A 1y93A-1hfsA:
29.2		 1y93A-1hfsA:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hmd HEMERYTHRIN

(Themiste
dyscritum) 		no annotation 4 ILE A  21
HIS A  73
HIS A  77
HIS A 101
 None
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 0.95A 1y93A-1hmdA:
undetectable		 1y93A-1hmdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hmd HEMERYTHRIN

(Themiste
dyscritum) 		no annotation 4 ILE A  21
HIS A  77
HIS A 101
HIS A  73
 None
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 0.73A 1y93A-1hmdA:
undetectable		 1y93A-1hmdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hmd HEMERYTHRIN

(Themiste
dyscritum) 		no annotation 4 ILE A  21
HIS A 101
HIS A  73
HIS A  77
 None
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 0.90A 1y93A-1hmdA:
undetectable		 1y93A-1hmdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 4.5A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
 0.22A 1y93A-1htdA:
11.4		 1y93A-1htdA:
24.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hv5 STROMELYSIN 3

(Mus musculus) 		PF00413
(Peptidase_M10) 		6 ILE A 180
HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 RXP  A6001 ( 3.8A)
ZN  A5501 (-3.6A)
ZN  A5502 ( 3.4A)
RXP  A6001 (-3.0A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.44A 1y93A-1hv5A:
24.2		 1y93A-1hv5A:
49.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iab ASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		4 HIS A  92
GLU A  93
HIS A  96
HIS A 102
 CO  A 999 (-3.2A)
CO  A 999 ( 4.3A)
CO  A 999 (-3.3A)
CO  A 999 (-3.1A)
 0.25A 1y93A-1iabA:
10.5		 1y93A-1iabA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		4 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.23A 1y93A-1kugA:
11.1		 1y93A-1kugA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6j MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.24A 1y93A-1l6jA:
25.2		 1y93A-1l6jA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		4 HIS A 264
GLU A 265
HIS A 268
HIS A 334
 ZN  A 578 ( 3.5A)
ZN  A 578 ( 4.1A)
ZN  A 578 ( 3.4A)
ZN  A 578 ( 3.4A)
 0.44A 1y93A-1lmlA:
8.5		 1y93A-1lmlA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 400 (-3.2A)
ZN  A 400 ( 4.4A)
ZN  A 400 (-3.3A)
ZN  A 400 (-3.2A)
 0.12A 1y93A-1nd1A:
11.2		 1y93A-1nd1A:
24.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qib 72 KDA TYPE IV
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 502 (-3.5A)
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
 0.31A 1y93A-1qibA:
26.8		 1y93A-1qibA:
59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qua ACUTOLYSIN-C

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.5A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
 0.11A 1y93A-1quaA:
11.3		 1y93A-1quaA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r55 ADAM 33

(Homo sapiens) 		PF01421
(Reprolysin) 		4 HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
 0.29A 1y93A-1r55A:
10.3		 1y93A-1r55A:
25.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rm8 MATRIX
METALLOPROTEINASE-16

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.18A 1y93A-1rm8A:
28.1		 1y93A-1rm8A:
50.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s58 B19 PARVOVIRUS
CAPSID

(Primate
erythroparvovirus
1) 		PF00740
(Parvo_coat) 		4 HIS A 513
GLU A 542
HIS A 517
HIS A 536
 None
 0.95A 1y93A-1s58A:
undetectable		 1y93A-1s58A:
15.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1slm STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.25A 1y93A-1slmA:
28.1		 1y93A-1slmA:
41.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1su3 INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 HIS A 183
HIS A 218
HIS A 222
HIS A 228
 ZN  A 915 (-3.3A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
 0.16A 1y93A-1su3A:
25.3		 1y93A-1su3A:
38.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis) 		PF01421
(Reprolysin) 		4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 (-3.5A)
ZN  A 999 ( 4.2A)
ZN  A 999 (-3.5A)
ZN  A 999 (-3.4A)
 0.21A 1y93A-1wniA:
11.2		 1y93A-1wniA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcr HYPOTHETICAL PROTEIN
PTD012

(Homo sapiens) 		PF08925
(DUF1907) 		4 HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
 0.97A 1y93A-1xcrA:
undetectable		 1y93A-1xcrA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv2 HYPOTHETICAL
PROTEIN, SIMILAR TO
ALPHA-ACETOLACTATE
DECARBOXYLASE

(Staphylococcus
aureus) 		PF03306
(AAL_decarboxy) 		4 HIS A 175
GLU A  45
HIS A 186
HIS A 173
 ZN  A 801 (-3.4A)
ZN  A 801 ( 4.4A)
ZN  A 801 (-3.3A)
ZN  A 801 (-3.5A)
 0.76A 1y93A-1xv2A:
undetectable		 1y93A-1xv2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y13 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Plasmodium
falciparum) 		PF01242
(PTPS) 		4 HIS A  41
GLU A  38
HIS A  29
HIS A  43
 ZN  A 174 ( 3.3A)
BIO  A 175 (-2.6A)
ZN  A 174 ( 3.5A)
ZN  A 174 ( 3.4A)
 0.92A 1y93A-1y13A:
undetectable		 1y93A-1y13A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp1 FII

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 (-3.3A)
ZN  A 999 ( 4.9A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
 0.27A 1y93A-1yp1A:
11.5		 1y93A-1yp1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoi ESTERASE

(Pseudomonas
putida) 		PF00561
(Abhydrolase_1) 		4 ILE A  12
GLU A 102
HIS A  28
HIS A  26
 None
 1.01A 1y93A-1zoiA:
undetectable		 1y93A-1zoiA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0s 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Plasmodium
vivax) 		PF01242
(PTPS) 		4 HIS A  48
GLU A  45
HIS A  36
HIS A  50
 ZN  A 281 (-3.3A)
BIO  A 282 (-3.1A)
ZN  A 281 ( 3.5A)
ZN  A 281 (-3.3A)
 0.91A 1y93A-2a0sA:
undetectable		 1y93A-2a0sA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH

(Desulfovibrio
vulgaris) 		PF01814
(Hemerythrin) 		4 ILE A  19
HIS A  78
HIS A  82
HIS A 118
 None
FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
 0.87A 1y93A-2awcA:
undetectable		 1y93A-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH

(Desulfovibrio
vulgaris) 		PF01814
(Hemerythrin) 		4 ILE A  19
HIS A  82
HIS A 118
HIS A  78
 None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.5A)
 0.82A 1y93A-2awcA:
undetectable		 1y93A-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH

(Desulfovibrio
vulgaris) 		PF01814
(Hemerythrin) 		4 ILE A  19
HIS A 118
HIS A  78
HIS A  82
 None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
 0.82A 1y93A-2awcA:
undetectable		 1y93A-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw1 CATROCOLLASTATIN

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 HIS A 333
GLU A 334
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
GM6  A   2 (-2.5A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.22A 1y93A-2dw1A:
10.6		 1y93A-2dw1A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN

(Daboia
siamensis) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
GM6  A 700 ( 3.4A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.25A 1y93A-2e3xA:
10.4		 1y93A-2e3xA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 HIS A 335
GLU A 336
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 ( 4.3A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.16A 1y93A-2erqA:
10.2		 1y93A-2erqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv5 ADAM 17

(Homo sapiens) 		PF13688
(Reprolysin_5) 		4 HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
 0.26A 1y93A-2fv5A:
9.8		 1y93A-2fv5A:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jsd MATRIX
METALLOPROTEINASE-20

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 HIS A 191
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 275 (-3.4A)
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
 0.78A 1y93A-2jsdA:
25.0		 1y93A-2jsdA:
54.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy4 NEUTROPHIL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 HIS A 162
HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 998 (-3.3A)
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
 0.19A 1y93A-2oy4A:
29.0		 1y93A-2oy4A:
53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy4 NEUTROPHIL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 ILE A 159
HIS A 162
GLU A 198
HIS A 201
HIS A 207
 None
ZN  A 998 (-3.3A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
 0.58A 1y93A-2oy4A:
29.0		 1y93A-2oy4A:
53.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.16A 1y93A-2rjqA:
10.5		 1y93A-2rjqA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		4 ILE A 272
HIS A 283
HIS A 329
HIS A 285
 None
MN  A1006 ( 3.4A)
MN  A1006 (-3.5A)
MN  A1006 ( 3.5A)
 0.89A 1y93A-2vqaA:
undetectable		 1y93A-2vqaA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		5 ILE A 272
HIS A 329
GLU A 290
HIS A 285
HIS A 283
 None
MN  A1006 (-3.5A)
MN  A1006 ( 2.3A)
MN  A1006 ( 3.5A)
MN  A1006 ( 3.4A)
 1.07A 1y93A-2vqaA:
undetectable		 1y93A-2vqaA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7m ARCHAEMETZINCIN

(Methanopyrus
kandleri) 		PF07998
(Peptidase_M54) 		4 HIS A 125
GLU A 126
HIS A 129
HIS A 135
 ZN  A1174 (-3.2A)
ZN  A1174 ( 4.2A)
ZN  A1174 (-3.2A)
ZN  A1174 (-3.2A)
 0.17A 1y93A-2x7mA:
10.8		 1y93A-2x7mA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN

(Salmonella
enterica) 		PF01297
(ZnuA) 		4 HIS A  60
HIS A 147
HIS A 140
HIS A 211
 None
ZN  A 401 (-3.3A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.3A)
 1.01A 1y93A-2xy4A:
2.5		 1y93A-2xy4A:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y6c MATRILYSIN

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.35A 1y93A-2y6cA:
26.2		 1y93A-2y6cA:
53.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
 0.11A 1y93A-3b8zA:
10.7		 1y93A-3b8zA:
23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ba0 MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		6 ILE A 180
HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 None
ZN  A 472 (-3.1A)
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
 0.80A 1y93A-3ba0A:
28.4		 1y93A-3ba0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu7 GENTISATE
1,2-DIOXYGENASE

(Ruegeria
pomeroyi) 		PF07883
(Cupin_2) 		4 ILE A 258
HIS A 290
HIS A 330
HIS A 292
 None
FE2  A 500 (-3.5A)
FE2  A 500 (-3.4A)
FE2  A 500 (-3.5A)
 0.76A 1y93A-3bu7A:
undetectable		 1y93A-3bu7A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cny INOSITOL CATABOLISM
PROTEIN IOLE

(Lactobacillus
plantarum) 		PF01261
(AP_endonuc_2) 		4 ILE A  16
HIS A 159
HIS A 161
HIS A 192
 None
 0.87A 1y93A-3cnyA:
undetectable		 1y93A-3cnyA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsl ZINC
METALLOPROTEINASE-DI
SINTEGRIN
BOTHROPASIN

(Bothrops
jararaca) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 HIS A 145
GLU A 146
HIS A 149
HIS A 155
 ZN  A 503 ( 3.3A)
TRP  A 505 (-2.4A)
ZN  A 503 ( 3.3A)
ZN  A 503 ( 3.3A)
 0.33A 1y93A-3dslA:
10.2		 1y93A-3dslA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edi TOLLOID-LIKE PROTEIN
1

(Homo sapiens) 		PF01400
(Astacin) 		4 HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
 0.16A 1y93A-3ediA:
9.8		 1y93A-3ediA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqe PUTATIVE CYSTEIN
DIOXYGENASE

(Bacillus
subtilis) 		PF05995
(CDO_I) 		4 ILE A  64
HIS A  77
HIS A  75
HIS A 125
 None
FE  A 202 (-3.6A)
FE  A 202 (-3.5A)
FE  A 202 (-3.5A)
 0.85A 1y93A-3eqeA:
undetectable		 1y93A-3eqeA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqe PUTATIVE CYSTEIN
DIOXYGENASE

(Bacillus
subtilis) 		PF05995
(CDO_I) 		4 ILE A  64
HIS A 125
HIS A  77
HIS A  75
 None
FE  A 202 (-3.5A)
FE  A 202 (-3.6A)
FE  A 202 (-3.5A)
 0.95A 1y93A-3eqeA:
undetectable		 1y93A-3eqeA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		4 HIS A 140
GLU A 141
HIS A 144
HIS A 150
 ZN  A 302 (-3.3A)
ZN  A 302 ( 4.6A)
ZN  A 302 (-3.3A)
ZN  A 302 (-3.2A)
 0.21A 1y93A-3gboA:
11.1		 1y93A-3gboA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdb AAHIV

(Deinagkistrodon
acutus) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 ILE A 298
HIS A 333
GLU A 334
HIS A 337
HIS A 343
 None
ZN  A 620 (-3.4A)
ZN  A 620 ( 4.2A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.59A 1y93A-3hdbA:
10.6		 1y93A-3hdbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra) 		PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 HIS A 341
GLU A 342
HIS A 345
HIS A 351
 ZN  A 704 (-3.1A)
ZN  A 704 ( 4.5A)
ZN  A 704 (-3.3A)
ZN  A 704 (-3.2A)
 0.19A 1y93A-3k7nA:
10.6		 1y93A-3k7nA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmc PEPTIDASE,
ZINC-DEPENDENT

(Methanocorpusculum
labreanum) 		PF07998
(Peptidase_M54) 		4 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.25A 1y93A-3lmcA:
8.2		 1y93A-3lmcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lot UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF05853
(BKACE) 		4 ILE A 201
HIS A  49
GLU A 261
HIS A  51
 UNL  A 503 ( 4.4A)
ZN  A 501 (-3.4A)
ZN  A 501 (-2.7A)
ZN  A 501 (-3.4A)
 0.98A 1y93A-3lotA:
undetectable		 1y93A-3lotA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqb LOC792177 PROTEIN

(Danio rerio) 		PF01400
(Astacin) 		4 HIS A  99
GLU A 100
HIS A 103
HIS A 109
 ZN  A 201 ( 3.2A)
SO4  A 200 (-3.0A)
ZN  A 201 ( 3.3A)
ZN  A 201 ( 3.2A)
 0.24A 1y93A-3lqbA:
10.4		 1y93A-3lqbA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans) 		PF05572
(Peptidase_M43) 		5 ILE A 187
HIS A 228
GLU A 229
HIS A 232
HIS A 238
 None
ZN  A 999 (-3.1A)
ZN  A 999 ( 3.8A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.56A 1y93A-3lunA:
8.6		 1y93A-3lunA:
23.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o2x COLLAGENASE 3

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 HIS A1187
HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1998 ( 3.2A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
 0.25A 1y93A-3o2xA:
29.0		 1y93A-3o2xA:
56.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis) 		PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm) 		5 ILE A 313
HIS A 348
GLU A 349
HIS A 352
HIS A 358
 None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.9A)
ZN  A 999 (-3.2A)
ZN  A 999 ( 3.2A)
 0.55A 1y93A-3p24A:
8.9		 1y93A-3p24A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1

(Homo sapiens) 		PF01421
(Reprolysin) 		4 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
 0.19A 1y93A-3q2hA:
10.7		 1y93A-3q2hA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		4 ILE A 593
GLU A 357
HIS A 361
HIS A 545
 OYP  A 664 (-4.3A)
OYP  A 664 (-3.6A)
FE2  A   1 ( 3.4A)
FE2  A   1 (-3.3A)
 0.87A 1y93A-3rdeA:
undetectable		 1y93A-3rdeA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1

(Paenarthrobacter
aurescens) 		PF00962
(A_deaminase) 		4 ILE A 139
HIS A  21
HIS A  19
HIS A 199
 None
ADE  A 345 ( 3.2A)
ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
 0.88A 1y93A-3rysA:
undetectable		 1y93A-3rysA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3shi INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.30A 1y93A-3shiA:
30.0		 1y93A-3shiA:
57.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u43 COLICIN-E2

(Escherichia
coli) 		no annotation 4 ILE B 107
HIS B 102
HIS B 127
HIS B 131
 None
ZN  B 135 (-3.2A)
ZN  B 135 (-3.3A)
ZN  B 135 (-3.4A)
 1.02A 1y93A-3u43B:
undetectable		 1y93A-3u43B:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v96 STROMELYSIN-2

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 HIS B 182
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.28A 1y93A-3v96B:
30.0		 1y93A-3v96B:
55.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		4 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 ZN  A 500 (-3.2A)
ZN  A 500 ( 4.2A)
ZN  A 500 (-3.3A)
ZN  A 500 (-3.2A)
 0.21A 1y93A-3vi1A:
13.1		 1y93A-3vi1A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtg HIGH CHORIOLYTIC
ENZYME 1

(Oryzias latipes) 		PF01400
(Astacin) 		4 HIS A  99
GLU A 100
HIS A 103
HIS A 109
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.16A 1y93A-3vtgA:
10.3		 1y93A-3vtgA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3w ARCHAEMETZINCIN

(Archaeoglobus
fulgidus) 		PF07998
(Peptidase_M54) 		4 HIS A 117
GLU A 118
HIS A 121
HIS A 127
 ZN  A1159 ( 3.2A)
FLC  A1161 (-2.9A)
ZN  A1159 ( 3.3A)
ZN  A1159 ( 3.2A)
 0.32A 1y93A-4a3wA:
8.1		 1y93A-4a3wA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		5 ILE A 107
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 FLX  A 400 (-3.9A)
ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.60A 1y93A-4aigA:
11.2		 1y93A-4aigA:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4auo INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		4 HIS A 164
HIS A 199
HIS A 203
HIS A 209
 ZN  A1201 (-3.1A)
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
 0.14A 1y93A-4auoA:
27.8		 1y93A-4auoA:
55.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE

(Brevibacillus
brevis) 		PF03306
(AAL_decarboxy) 		4 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.83A 1y93A-4bt6A:
undetectable		 1y93A-4bt6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8

(Homo sapiens) 		PF01421
(Reprolysin) 		4 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.40A 1y93A-4dd8A:
10.3		 1y93A-4dd8A:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fvl COLLAGENASE 3

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		4 HIS A 187
HIS A 222
HIS A 226
HIS A 232
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
 0.36A 1y93A-4fvlA:
28.4		 1y93A-4fvlA:
55.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gr8 MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		6 ILE A 180
HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 R4C  A 306 (-4.3A)
ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.30A 1y93A-4gr8A:
30.0		 1y93A-4gr8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwn MEPRIN A SUBUNIT
BETA

(Homo sapiens) 		PF00629
(MAM)
PF01400
(Astacin) 		4 HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.29A 1y93A-4gwnA:
9.2		 1y93A-4gwnA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria) 		PF00962
(A_deaminase) 		4 ILE A 154
HIS A  36
HIS A  34
HIS A 215
 None
ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.4A)
 0.89A 1y93A-4gxwA:
undetectable		 1y93A-4gxwA:
18.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4in9 KARILYSIN PROTEASE

(Tannerella
forsythia) 		PF00413
(Peptidase_M10) 		5 HIS A 117
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 302 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.32A 1y93A-4in9A:
23.5		 1y93A-4in9A:
39.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		4 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
 0.15A 1y93A-4j4mA:
11.3		 1y93A-4j4mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jiu PROABYLYSIN

(Pyrococcus
abyssi) 		PF01863
(DUF45) 		4 HIS A  60
GLU A  61
HIS A  64
HIS A  72
 ZN  A 201 (-3.2A)
ZN  A 201 ( 4.8A)
ZN  A 201 (-3.2A)
ZN  A 201 (-3.2A)
 0.36A 1y93A-4jiuA:
4.6		 1y93A-4jiuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jix PROJANNALYSIN

(Methanocaldococcus
jannaschii) 		PF01863
(DUF45) 		4 HIS A  69
GLU A  70
HIS A  73
HIS A  81
 ZN  A 201 (-3.3A)
TRS  A 202 (-3.8A)
ZN  A 201 ( 3.3A)
ZN  A 201 (-3.3A)
 0.52A 1y93A-4jixA:
4.7		 1y93A-4jixA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l63 ECXA

(Escherichia
coli) 		PF16313
(DUF4953) 		4 HIS A 179
GLU A 180
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.4A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.17A 1y93A-4l63A:
11.5		 1y93A-4l63A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1l SNAKE VENOM
METALLOPROTEINASE
LEUCUROLYSIN-A

(Bothrops
leucurus) 		PF01421
(Reprolysin) 		4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 302 (-3.2A)
ZN  A 302 ( 4.7A)
ZN  A 302 (-3.1A)
ZN  A 302 (-3.1A)
 0.17A 1y93A-4q1lA:
11.3		 1y93A-4q1lA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhi UNCHARACTERIZED
PROTEIN MJ1213

(Methanocaldococcus
jannaschii) 		PF01435
(Peptidase_M48) 		4 HIS A  69
GLU A  70
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
GOL  A 202 (-3.1A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.39A 1y93A-4qhiA:
6.0		 1y93A-4qhiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4

(Homo sapiens) 		PF01421
(Reprolysin) 		4 HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.24A 1y93A-4wk7A:
10.9		 1y93A-4wk7A:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 HIS A 190
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.16A 1y93A-4xctA:
29.1		 1y93A-4xctA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avp L-RIBOSE ISOMERASE

(Geodermatophilus
obscurus) 		no annotation 4 ILE A  69
HIS A 110
HIS A 192
HIS A 112
 None
MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
MN  A 401 (-3.5A)
 0.98A 1y93A-5avpA:
undetectable		 1y93A-5avpA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 301 ( 3.4A)
ZN  A 301 ( 4.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.1A)
 0.33A 1y93A-5czwA:
11.4		 1y93A-5czwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.30A 1y93A-5d7wA:
14.1		 1y93A-5d7wA:
26.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h0u MATRIX
METALLOPROTEINASE-14

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 HIS A 201
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.38A 1y93A-5h0uA:
28.1		 1y93A-5h0uA:
50.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C

(Schizosaccharomyces
pombe) 		PF08325
(WLM) 		4 HIS A  97
GLU A  98
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
OXY  A 202 (-2.8A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.31A 1y93A-5jigA:
3.2		 1y93A-5jigA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.21A 1y93A-5th6A:
25.0		 1y93A-5th6A:
35.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 ILE A 524
HIS A 489
GLU A 460
HIS A  19
 None
 0.88A 1y93A-5wu7A:
undetectable		 1y93A-5wu7A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbn WSS1P

(Saccharomyces
cerevisiae) 		no annotation 4 HIS A 115
GLU A 116
HIS A 119
HIS A 125
 ZN  A 201 (-3.2A)
ZN  A 201 ( 4.7A)
ZN  A 201 (-3.3A)
ZN  A 201 (-3.2A)
 0.26A 1y93A-5xbnA:
5.0		 1y93A-5xbnA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xne -

(-) 		no annotation 4 HIS B 193
GLU B  62
HIS B 204
HIS B 191
 ZN  B 301 (-3.4A)
ZN  B 301 ( 4.5A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.5A)
 0.81A 1y93A-5xneB:
undetectable		 1y93A-5xneB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 4 HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
 0.49A 1y93A-6bdzA:
10.0		 1y93A-6bdzA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btp -

(-) 		no annotation 4 HIS A  93
GLU A  94
HIS A  97
HIS A 103
 ZN  A 302 ( 3.3A)
E8J  A 304 (-2.6A)
ZN  A 302 ( 3.4A)
ZN  A 302 ( 3.3A)
 0.17A 1y93A-6btpA:
9.7		 1y93A-6btpA:
undetectable