SIMILAR PATTERNS OF AMINO ACIDS FOR 1Y7I_A_SALA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a81 SYK KINASE

(Homo sapiens) 		PF00017
(SH2) 		3 LEU A 214
HIS A 209
LYS A 212
 None
 0.83A 1y7iA-1a81A:
undetectable		 1y7iA-1a81A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddb PROTEIN (BID)

(Mus musculus) 		PF06393
(BID) 		3 LEU A 127
HIS A 172
LYS A 123
 None
 1.02A 1y7iA-1ddbA:
undetectable		 1y7iA-1ddbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0c ICE INHIBITOR

(Cowpox virus) 		PF00079
(Serpin) 		3 LEU B 383
HIS B 376
LYS B 381
 None
 0.97A 1y7iA-1f0cB:
undetectable		 1y7iA-1f0cB:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1faf LARGE T ANTIGEN

(Mus musculus
polyomavirus 1) 		no annotation 3 LEU A  39
HIS A  42
LYS A  45
 None
 1.02A 1y7iA-1fafA:
undetectable		 1y7iA-1fafA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcw PROTEIN (HEMOGLOBIN)

(Mustelus
griseus) 		PF00042
(Globin) 		3 LEU B  86
HIS B  82
LYS B  81
 HEM  B 136 (-4.0A)
HEM  B 136 (-3.5A)
HEM  B 136 ( 4.4A)
 1.06A 1y7iA-1gcwB:
undetectable		 1y7iA-1gcwB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyd ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE A

(Cellvibrio
japonicus) 		PF04616
(Glyco_hydro_43) 		3 LEU B 278
HIS B 250
LYS B 281
 None
 0.94A 1y7iA-1gydB:
undetectable		 1y7iA-1gydB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdj HUMAN HSP40

(Homo sapiens) 		PF00226
(DnaJ) 		3 LEU A  28
HIS A  31
LYS A  34
 None
 0.85A 1y7iA-1hdjA:
undetectable		 1y7iA-1hdjA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2m 17-KDA
PKC-POTENTIATED
INHIBITORY PROTEIN
OF PP1

(Sus scrofa) 		PF05361
(PP1_inhibitor) 		3 LEU A   9
HIS A  13
LYS A  19
 None
 1.06A 1y7iA-1j2mA:
undetectable		 1y7iA-1j2mA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		3 LEU A 614
HIS A 617
LYS A 620
 None
 1.02A 1y7iA-1ku1A:
undetectable		 1y7iA-1ku1A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otg 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE

(Escherichia
coli) 		PF02962
(CHMI) 		3 LEU A 110
HIS A   3
LYS A  67
 None
 0.93A 1y7iA-1otgA:
undetectable		 1y7iA-1otgA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LEU A 409
HIS A 398
LYS A 401
 None
 1.02A 1y7iA-1pcgA:
undetectable		 1y7iA-1pcgA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 LEU A  68
HIS A 135
LYS A  64
 None
 1.04A 1y7iA-1qf7A:
4.1		 1y7iA-1qf7A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq4 GLYOXYLATE-INDUCED
PROTEIN

(Pseudomonas
aeruginosa) 		PF07883
(Cupin_2) 		3 LEU A 262
HIS A 214
LYS A 264
 SCN  A 302 ( 4.5A)
None
SCN  A 302 ( 3.9A)
 0.99A 1y7iA-1sq4A:
undetectable		 1y7iA-1sq4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		3 LEU A 170
HIS A 173
LYS A 174
 None
 1.05A 1y7iA-1susA:
1.3		 1y7iA-1susA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txl METAL-BINDING
PROTEIN YODA

(Escherichia
coli) 		PF09223
(ZinT) 		3 LEU A  68
HIS A  97
LYS A  93
 None
 1.02A 1y7iA-1txlA:
undetectable		 1y7iA-1txlA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wia HYPOTHETICAL
UBIQUITIN-LIKE
PROTEIN (RIKEN CDNA
2010008E23)

(Mus musculus) 		PF00240
(ubiquitin) 		3 LEU A 208
HIS A 230
LYS A 201
 None
 0.99A 1y7iA-1wiaA:
undetectable		 1y7iA-1wiaA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		3 LEU A 283
HIS A 276
LYS A 281
 None
 0.95A 1y7iA-1x9sA:
undetectable		 1y7iA-1x9sA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR

(Homo sapiens) 		PF00089
(Trypsin) 		3 LEU A 625
HIS A 626
LYS A 627
 None
 1.06A 1y7iA-1ybwA:
undetectable		 1y7iA-1ybwA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzs SULFIREDOXIN

(Homo sapiens) 		PF02195
(ParBc) 		3 LEU A  65
HIS A 100
LYS A  61
 None
 1.07A 1y7iA-1yzsA:
undetectable		 1y7iA-1yzsA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3d MODULATOR OF DRUG
ACTIVITY B

(Escherichia
coli) 		PF02525
(Flavodoxin_2) 		3 LEU A 160
HIS A 163
LYS A 164
 None
 0.84A 1y7iA-2b3dA:
3.7		 1y7iA-2b3dA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		3 LEU A 242
HIS A 539
LYS A 246
 None
 1.11A 1y7iA-2btvA:
undetectable		 1y7iA-2btvA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctp DNAJ HOMOLOG
SUBFAMILY B MEMBER
12

(Homo sapiens) 		PF00226
(DnaJ) 		3 LEU A  33
HIS A  36
LYS A  39
 None
 1.01A 1y7iA-2ctpA:
undetectable		 1y7iA-2ctpA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE

(Archaeoglobus
fulgidus) 		PF05889
(SepSecS) 		3 LEU A 293
HIS A 306
LYS A 291
 None
 0.93A 1y7iA-2e7jA:
2.2		 1y7iA-2e7jA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		3 LEU A 602
HIS A 539
LYS A 535
 None
 1.02A 1y7iA-2eaeA:
undetectable		 1y7iA-2eaeA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		3 LEU A 681
HIS A 635
LYS A 686
 None
 1.01A 1y7iA-2ec5A:
undetectable		 1y7iA-2ec5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epf PSEUDECIN

(Pseudechis
porphyriacus) 		PF00188
(CAP)
PF08562
(Crisp) 		3 LEU A  16
HIS A  13
LYS A  12
 None
 1.13A 1y7iA-2epfA:
undetectable		 1y7iA-2epfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiy PROTEIN FDHE HOMOLOG

(Pseudomonas
aeruginosa) 		PF04216
(FdhE) 		3 LEU A 206
HIS A 219
LYS A  19
 None
 1.10A 1y7iA-2fiyA:
undetectable		 1y7iA-2fiyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER

(Bacillus
subtilis) 		PF07470
(Glyco_hydro_88) 		3 LEU A 260
HIS A 314
LYS A 315
 None
 1.02A 1y7iA-2gh4A:
undetectable		 1y7iA-2gh4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkr ATAXIN-7

(Homo sapiens) 		PF08313
(SCA7) 		3 LEU A 386
HIS A 389
LYS A 390
 None
 1.10A 1y7iA-2kkrA:
undetectable		 1y7iA-2kkrA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n26 ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17

(Homo sapiens) 		PF00096
(zf-C2H2) 		3 LEU A  75
HIS A  78
LYS A  79
 None
ZN  A 201 (-3.2A)
None
 1.07A 1y7iA-2n26A:
undetectable		 1y7iA-2n26A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrr UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		3 LEU A 371
HIS A 370
LYS A 375
 None
 1.12A 1y7iA-2nrrA:
undetectable		 1y7iA-2nrrA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN

(Arabidopsis
thaliana) 		PF01636
(APH) 		3 LEU A  96
HIS A  93
LYS A  92
 None
 0.98A 1y7iA-2pywA:
undetectable		 1y7iA-2pywA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE

(Trypanosoma
brucei) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 LEU A 487
HIS A 419
LYS A 388
 None
 1.02A 1y7iA-2wbaA:
undetectable		 1y7iA-2wbaA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwx DRRA

(Legionella
pneumophila) 		no annotation 3 LEU B 493
HIS B 496
LYS B 497
 None
 1.09A 1y7iA-2wwxB:
undetectable		 1y7iA-2wwxB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01661
(Macro) 		3 LEU A 255
HIS A 294
LYS A 297
 None
 1.02A 1y7iA-2x47A:
undetectable		 1y7iA-2x47A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Methanocaldococcus
jannaschii) 		PF01259
(SAICAR_synt) 		3 LEU A 195
HIS A  75
LYS A  88
 None
ATP  A1527 (-4.1A)
None
 1.12A 1y7iA-2z02A:
undetectable		 1y7iA-2z02A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxx DNA REPLICATION
FACTOR CDT1

(Mus musculus) 		PF08839
(CDT1) 		3 LEU C 197
HIS C 322
LYS C 319
 None
 1.06A 1y7iA-2zxxC:
undetectable		 1y7iA-2zxxC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		3 LEU A 544
HIS A 637
LYS A 549
 None
 0.98A 1y7iA-3aibA:
undetectable		 1y7iA-3aibA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 LEU A  63
HIS A 297
LYS A 296
 None
 0.81A 1y7iA-3b5qA:
undetectable		 1y7iA-3b5qA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b95 EUCHROMATIC
HISTONE-LYSINE
N-METHYLTRANSFERASE
1

(Homo sapiens) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		3 LEU A 814
HIS A 813
LYS A 817
 None
 1.07A 1y7iA-3b95A:
undetectable		 1y7iA-3b95A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		3 LEU A 366
HIS A  30
LYS A  33
 None
 0.89A 1y7iA-3beoA:
7.7		 1y7iA-3beoA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl9 SCAVENGER
MRNA-DECAPPING
ENZYME DCPS

(Homo sapiens) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		3 LEU A  53
HIS A  65
LYS A  51
 None
 1.04A 1y7iA-3bl9A:
undetectable		 1y7iA-3bl9A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		3 LEU A 361
HIS A 441
LYS A 437
 None
 1.03A 1y7iA-3du4A:
undetectable		 1y7iA-3du4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxr MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM10
MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM9

(Saccharomyces
cerevisiae) 		PF02953
(zf-Tim10_DDP) 		3 LEU B  54
HIS A  66
LYS A  62
 None
 1.05A 1y7iA-3dxrB:
undetectable		 1y7iA-3dxrB:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC

(Oryza sativa) 		no annotation 3 LEU O 223
HIS O 167
LYS O 164
 None
 1.08A 1y7iA-3e6aO:
3.7		 1y7iA-3e6aO:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0i ARSENATE REDUCTASE

(Vibrio cholerae) 		PF03960
(ArsC) 		3 LEU A  65
HIS A  88
LYS A  90
 None
 0.91A 1y7iA-3f0iA:
undetectable		 1y7iA-3f0iA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1

(Homo sapiens) 		PF00620
(RhoGAP) 		3 LEU A1277
HIS A1378
LYS A1381
 None
 1.07A 1y7iA-3fk2A:
undetectable		 1y7iA-3fk2A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 LEU X  81
HIS X  53
LYS X  85
 None
 1.08A 1y7iA-3jb9X:
undetectable		 1y7iA-3jb9X:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Danio rerio) 		PF12940
(RAG1) 		3 LEU A1015
HIS A1012
LYS A1011
 None
 1.08A 1y7iA-3jbyA:
undetectable		 1y7iA-3jbyA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrt INTEGRON CASSETTE
PROTEIN VPC_CASS2

(Vibrio
paracholerae) 		no annotation 3 LEU A  37
HIS A  42
LYS A  45
 None
 1.11A 1y7iA-3jrtA:
undetectable		 1y7iA-3jrtA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jza UNCHARACTERIZED
PROTEIN DRRA

(Legionella
pneumophila) 		no annotation 3 LEU B 493
HIS B 496
LYS B 497
 None
 1.09A 1y7iA-3jzaB:
undetectable		 1y7iA-3jzaB:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9q PROTEIN
MALE-SPECIFIC
LETHAL-3

(Drosophila
melanogaster) 		no annotation 3 LEU A  36
HIS A  55
LYS A  34
 None
 1.08A 1y7iA-3m9qA:
undetectable		 1y7iA-3m9qA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6o GUANINE NUCLEOTIDE
EXCHANGE FACTOR

(Legionella
pneumophila) 		PF14860
(DrrA_P4M) 		3 LEU A 493
HIS A 496
LYS A 497
 None
 1.04A 1y7iA-3n6oA:
undetectable		 1y7iA-3n6oA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		3 LEU A  16
HIS A 152
LYS A  10
 None
 1.13A 1y7iA-3o98A:
undetectable		 1y7iA-3o98A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdx TYROSINE
AMINOTRANSFERASE

(Mus musculus) 		PF00155
(Aminotran_1_2) 		3 LEU A 198
HIS A 229
LYS A 232
 None
 0.90A 1y7iA-3pdxA:
2.6		 1y7iA-3pdxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7

(Sphingopyxis
macrogoltabida) 		PF00067
(p450) 		3 LEU A 269
HIS A 272
LYS A 273
 None
 1.12A 1y7iA-3rwlA:
undetectable		 1y7iA-3rwlA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00701
(DHDPS) 		3 LEU A 207
HIS A 210
LYS A 211
 None
 1.13A 1y7iA-3s5nA:
undetectable		 1y7iA-3s5nA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sei CASKIN-1

(Homo sapiens) 		PF00536
(SAM_1) 		3 LEU A  19
HIS A  54
LYS A  57
 None
 1.13A 1y7iA-3seiA:
undetectable		 1y7iA-3seiA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		3 LEU A 654
HIS A 436
LYS A 439
 None
 1.12A 1y7iA-3t6gA:
undetectable		 1y7iA-3t6gA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-BETA-1

(Mus musculus) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		3 LEU C 620
HIS C 656
LYS C 659
 None
 1.11A 1y7iA-3tadC:
undetectable		 1y7iA-3tadC:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		3 LEU B 239
HIS B 234
LYS B 231
 None
 1.12A 1y7iA-3thwB:
undetectable		 1y7iA-3thwB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlx ADENYLATE KINASE 2

(Plasmodium
falciparum) 		PF00406
(ADK)
PF05191
(ADK_lid) 		3 LEU A  46
HIS A  56
LYS A  49
 None
 1.04A 1y7iA-3tlxA:
1.6		 1y7iA-3tlxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LEU A 692
HIS A 599
LYS A 694
 None
 0.69A 1y7iA-3v5qA:
undetectable		 1y7iA-3v5qA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo sapiens) 		PF01593
(Amino_oxidase) 		3 LEU A 224
HIS A  24
LYS A  21
 None
 0.95A 1y7iA-3zyxA:
undetectable		 1y7iA-3zyxA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acz ENDO-ALPHA-MANNOSIDA
SE

(Bacteroides
thetaiotaomicron) 		PF16317
(Glyco_hydro_99) 		3 LEU B 223
HIS B 185
LYS B 187
 GOL  B1379 (-4.6A)
GOL  B1379 ( 3.8A)
GOL  B1379 (-3.0A)
 0.95A 1y7iA-4aczB:
undetectable		 1y7iA-4aczB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LEU A 705
HIS A 615
LYS A 707
 None
 0.71A 1y7iA-4at3A:
undetectable		 1y7iA-4at3A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 292
HIS A 124
LYS A 121
 None
ACT  A1004 (-3.8A)
None
 1.03A 1y7iA-4bgqA:
undetectable		 1y7iA-4bgqA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkh PUTATIVE TYPE VI
SECRETION PROTEIN

(Escherichia
coli) 		PF05638
(T6SS_HCP) 		3 LEU A 132
HIS A 119
LYS A 129
 None
 1.07A 1y7iA-4hkhA:
undetectable		 1y7iA-4hkhA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Jonesia
denitrificans) 		PF16262
(DUF4916) 		3 LEU A  37
HIS A 129
LYS A  32
 CL  A 208 (-4.0A)
None
None
 1.09A 1y7iA-4ktbA:
undetectable		 1y7iA-4ktbA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw3 NS1

(Human bocavirus) 		no annotation 3 LEU A  89
HIS A  92
LYS A  93
 None
 0.79A 1y7iA-4kw3A:
undetectable		 1y7iA-4kw3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE

(Naegleria
gruberi) 		no annotation 3 LEU A 314
HIS A 317
LYS A 318
 None
 1.10A 1y7iA-4lt5A:
undetectable		 1y7iA-4lt5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		3 LEU A  25
HIS A  40
LYS A  23
 None
None
CL  A 405 ( 4.3A)
 1.02A 1y7iA-4m69A:
undetectable		 1y7iA-4m69A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		3 LEU A 153
HIS A 515
LYS A 514
 None
 1.05A 1y7iA-4nhyA:
undetectable		 1y7iA-4nhyA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s24 MODULATOR OF DRUG
ACTIVITY B

(Yersinia pestis) 		PF02525
(Flavodoxin_2) 		3 LEU A 149
HIS A 152
LYS A 153
 None
PEG  A 203 ( 4.2A)
None
 0.89A 1y7iA-4s24A:
2.3		 1y7iA-4s24A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Actinomyces
urogenitalis) 		PF00977
(His_biosynth) 		3 LEU A  92
HIS A 119
LYS A 122
 None
 1.12A 1y7iA-4x2rA:
2.1		 1y7iA-4x2rA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj5 CYCLIC AMP-GMP
SYNTHASE

(Vibrio cholerae) 		no annotation 3 LEU A 322
HIS A 278
LYS A 281
 None
EDO  A1012 ( 4.7A)
None
 0.75A 1y7iA-4xj5A:
undetectable		 1y7iA-4xj5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypw TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Haemophilus
influenzae) 		PF01746
(tRNA_m1G_MT) 		3 LEU A  30
HIS A   0
LYS A  -2
 None
 1.04A 1y7iA-4ypwA:
undetectable		 1y7iA-4ypwA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		3 LEU A 162
HIS A 165
LYS A 166
 None
 1.08A 1y7iA-5a22A:
2.1		 1y7iA-5a22A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq6 METAL-BINDING
PROTEIN ZINT

(Escherichia
coli) 		PF09223
(ZinT) 		3 LEU A  46
HIS A  75
LYS A  71
 None
ZN  A1197 ( 3.2A)
None
 1.11A 1y7iA-5aq6A:
undetectable		 1y7iA-5aq6A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg9 TET-LIKE DIOXYGENASE

(Naegleria
gruberi) 		no annotation 3 LEU A 314
HIS A 317
LYS A 318
 None
 1.06A 1y7iA-5cg9A:
undetectable		 1y7iA-5cg9A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L16

(Deinococcus
radiodurans) 		PF00252
(Ribosomal_L16) 		3 LEU J 121
HIS J 124
LYS J 125
 C  X2467 ( 4.8A)
C  X2467 ( 3.5A)
C  X2467 ( 3.0A)
 0.88A 1y7iA-5dm6J:
undetectable		 1y7iA-5dm6J:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Haemophilus
influenzae) 		PF00005
(ABC_tran) 		3 LEU A 571
HIS A 581
LYS A 578
 None
 1.07A 1y7iA-5eumA:
undetectable		 1y7iA-5eumA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2a KLLA0C04147P

(Kluyveromyces
lactis) 		PF00023
(Ank) 		3 LEU A 237
HIS A 203
LYS A 232
 None
 1.06A 1y7iA-5h2aA:
undetectable		 1y7iA-5h2aA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1t STAGE II SPORULATION
PROTEIN D

(Clostridioides
difficile) 		PF08486
(SpoIID) 		3 LEU A 191
HIS A 128
LYS A 125
 CTO  A 404 (-4.7A)
None
CTO  A 404 ( 4.9A)
 1.05A 1y7iA-5i1tA:
undetectable		 1y7iA-5i1tA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixd TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 3 LEU A 155
HIS A 264
LYS A 267
 None
 1.12A 1y7iA-5ixdA:
undetectable		 1y7iA-5ixdA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iys PHYTOENE SYNTHASE

(Enterococcus
hirae) 		PF00494
(SQS_PSY) 		3 LEU A  32
HIS A 272
LYS A 275
 None
 1.09A 1y7iA-5iysA:
undetectable		 1y7iA-5iysA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		3 LEU A  91
HIS A 100
LYS A  95
 None
 0.80A 1y7iA-5jpnA:
undetectable		 1y7iA-5jpnA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6z PROTEIN
SIDEKICK-2,PROTEIN
SIDEKICK-1 CHIMERA

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 LEU A 340
HIS A 346
LYS A 338
 None
 1.01A 1y7iA-5k6zA:
undetectable		 1y7iA-5k6zA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 LEU A 491
HIS A 497
LYS A 496
 None
 1.05A 1y7iA-5k8dA:
undetectable		 1y7iA-5k8dA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmi 50S RIBOSOMAL
PROTEIN L34,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00468
(Ribosomal_L34) 		3 LEU 3 108
HIS 3 112
LYS 3 141
 U  A 697 ( 4.4A)
U  A 476 ( 3.9A)
U  A 476 ( 3.4A)
 0.92A 1y7iA-5mmi3:
undetectable		 1y7iA-5mmi3:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 3 LEU A 551
HIS A 554
LYS A 555
 GOL  A 802 ( 3.6A)
None
GOL  A 802 (-3.1A)
 1.09A 1y7iA-5oasA:
undetectable		 1y7iA-5oasA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpr 3-DEHYDROQUINATE
SYNTHASE

(Trichormus
variabilis) 		PF01761
(DHQ_synthase) 		3 LEU A 378
HIS A 381
LYS A 382
 None
 1.05A 1y7iA-5tprA:
3.2		 1y7iA-5tprA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsc UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 LEU A 339
HIS A  12
LYS A  16
 None
 1.13A 1y7iA-5tscA:
undetectable		 1y7iA-5tscA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 LEU A 317
HIS A 314
LYS A 313
 None
 1.07A 1y7iA-5u3cA:
3.6		 1y7iA-5u3cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL

(Aspergillus
fumigatus) 		no annotation 3 LEU A 123
HIS A  95
LYS A  97
 None
 1.07A 1y7iA-5uqrA:
undetectable		 1y7iA-5uqrA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwl KINETOCHORE PROTEIN
NNF1

(Schizosaccharomyces
pombe) 		no annotation 3 LEU N 109
HIS N 112
LYS N 113
 None
 1.12A 1y7iA-5wwlN:
undetectable		 1y7iA-5wwlN:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 3 LEU A2217
HIS A2089
LYS A2130
 None
 1.06A 1y7iA-5y2aA:
2.2		 1y7iA-5y2aA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 3 LEU A 993
HIS A 990
LYS A 989
 None
 1.02A 1y7iA-6cg0A:
undetectable		 1y7iA-6cg0A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 3 LEU B 303
HIS B 266
LYS B 265
 None
NAD  A 502 (-3.6A)
None
 0.89A 1y7iA-6dftB:
2.7		 1y7iA-6dftB:
undetectable