SIMILAR PATTERNS OF AMINO ACIDS FOR 1Y7I_A_SALA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		5 GLY B1521
ALA B1609
SER B1599
LEU B1602
LEU B1543
 None
 1.26A 1y7iA-1a9xB:
3.1		 1y7iA-1a9xB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		5 GLY A  38
SER A  83
LEU A  39
PHE A 306
LEU A 237
 None
 1.41A 1y7iA-1epxA:
undetectable		 1y7iA-1epxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		5 ALA A 329
SER A 352
LEU A 353
TYR A 360
LEU A 425
 None
 1.34A 1y7iA-1fbwA:
undetectable		 1y7iA-1fbwA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		5 GLY A  37
ALA A  39
SER A  41
LEU A  40
LEU A  50
 None
 1.45A 1y7iA-1ghsA:
undetectable		 1y7iA-1ghsA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		5 GLY A 192
ALA A 193
LEU A 191
TRP A 144
LEU A 152
 None
 1.38A 1y7iA-1kcxA:
undetectable		 1y7iA-1kcxA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 GLY C 443
SER C 421
LEU C 444
PHE C 465
LEU C 473
 None
 1.44A 1y7iA-1n8yC:
undetectable		 1y7iA-1n8yC:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgt PROTEIN (HBV CAPSID
PROTEIN)

(Hepatitis B
virus) 		no annotation 5 ALA C  11
LEU C 116
TRP C 102
LEU C 119
HIS C  51
 None
 1.40A 1y7iA-1qgtC:
undetectable		 1y7iA-1qgtC:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgt PROTEIN (HBV CAPSID
PROTEIN)

(Hepatitis B
virus) 		no annotation 5 GLY C  10
ALA C  11
TRP C 102
LEU C 119
HIS C  51
 None
 1.02A 1y7iA-1qgtC:
undetectable		 1y7iA-1qgtC:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqj FUMARYLACETOACETATE
HYDROLASE

(Mus musculus) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		5 GLY A  52
ALA A  54
SER A  56
LEU A  55
LEU A  73
 None
 1.14A 1y7iA-1qqjA:
undetectable		 1y7iA-1qqjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 GLY A 501
ALA A 499
LEU A 500
PHE A 440
LEU A 462
 None
 1.40A 1y7iA-1rqgA:
undetectable		 1y7iA-1rqgA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 331
SER A 136
LEU A 333
TYR A 153
HIS A 171
 None
 1.34A 1y7iA-1rvkA:
undetectable		 1y7iA-1rvkA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR

(Geobacillus
stearothermophilus) 		PF12146
(Hydrolase_4) 		5 GLY A  24
SER A  94
LEU A  95
LEU A 167
HIS A 223
 4PA  A 701 (-3.6A)
4PA  A 701 (-1.4A)
4PA  A 701 (-4.2A)
None
4PA  A 701 (-4.4A)
 0.85A 1y7iA-1tqhA:
15.9		 1y7iA-1tqhA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqr 3-DEHYDROQUINATE
DEHYDRATASE

(Actinobacillus
pleuropneumoniae) 		PF01220
(DHquinase_II) 		5 GLY A  53
ALA A  51
SER A  56
LEU A  57
LEU A   7
 SO4  A1147 (-3.5A)
None
None
None
None
 1.43A 1y7iA-1uqrA:
4.7		 1y7iA-1uqrA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve2 UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		5 GLY A 120
ALA A 121
SER A 123
LEU A 122
LEU A 185
 None
 1.35A 1y7iA-1ve2A:
undetectable		 1y7iA-1ve2A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn9 THE HYPOTHETICAL
PROTEIN (TT1805)

(Thermus
thermophilus) 		PF11432
(DUF3197) 		5 GLY A  85
ALA A  86
LEU A  26
PHE A  89
LEU A  50
 None
 1.03A 1y7iA-1wn9A:
undetectable		 1y7iA-1wn9A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwu HYPOTHETICAL PROTEIN
FLJ21935

(Homo sapiens) 		no annotation 5 GLY A  70
LEU A  62
TRP A  32
PHE A  38
LEU A  54
 None
 1.26A 1y7iA-1wwuA:
undetectable		 1y7iA-1wwuA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 GLY A 391
ALA A 393
SER A 390
TYR A 559
HIS A 573
 None
 1.24A 1y7iA-1z8lA:
2.5		 1y7iA-1z8lA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		5 GLY A 291
SER A 292
LEU A 293
LEU A 223
HIS A 252
 None
None
None
None
GAI  A1001 (-4.9A)
 1.27A 1y7iA-2cevA:
3.8		 1y7iA-2cevA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE

(Luciola
cruciata) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A  26
ALA A  25
LEU A  98
PHE A 221
LEU A 196
 None
 1.04A 1y7iA-2d1qA:
undetectable		 1y7iA-2d1qA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 GLY A 195
ALA A 196
SER A 192
LEU A 191
TRP A 182
 FAD  A 700 (-3.3A)
None
FAD  A 700 (-2.6A)
FAD  A 700 (-4.2A)
None
 1.09A 1y7iA-2i0kA:
undetectable		 1y7iA-2i0kA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE

(Paenarthrobacter
nicotinovorans) 		PF06500
(DUF1100) 		5 GLY A 146
SER A 217
LEU A 218
LEU A 279
HIS A 329
 None
 1.36A 1y7iA-2jbwA:
13.5		 1y7iA-2jbwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 GLY A 391
ALA A 390
LEU A 412
PHE A 368
LEU A 401
 None
 1.12A 1y7iA-2omvA:
undetectable		 1y7iA-2omvA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p65 HYPOTHETICAL PROTEIN
PF08_0063

(Plasmodium
falciparum) 		PF00004
(AAA) 		5 GLY A 141
ALA A 140
LEU A 144
PHE A  99
LEU A  84
 None
 1.15A 1y7iA-2p65A:
undetectable		 1y7iA-2p65A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6r AFUHEL308 HELICASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 GLY A 509
ALA A 510
SER A 506
LEU A 505
LEU A 500
 None
 1.32A 1y7iA-2p6rA:
undetectable		 1y7iA-2p6rA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus) 		PF00400
(WD40) 		5 ALA B 171
SER B 214
LEU B 201
LEU B 169
HIS B 194
 None
 1.42A 1y7iA-2pbiB:
undetectable		 1y7iA-2pbiB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbk KSHV PROTEASE

(Human
gammaherpesvirus
8) 		PF00716
(Peptidase_S21) 		5 ALA A  80
LEU A 102
TYR A 150
PHE A  76
LEU A   5
 None
ACT  A 602 (-4.0A)
None
None
None
 1.36A 1y7iA-2pbkA:
undetectable		 1y7iA-2pbkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 GLY A 869
ALA A 867
LEU A 871
PHE A1128
LEU A1097
 None
 1.44A 1y7iA-2vdcA:
undetectable		 1y7iA-2vdcA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82

(Saccharomyces
cerevisiae) 		no annotation 5 ALA B 266
SER B 257
LEU B 256
LEU B 345
HIS B 240
 None
 1.14A 1y7iA-2vduB:
undetectable		 1y7iA-2vduB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0f WSAF

(Geobacillus
stearothermophilus) 		no annotation 5 GLY A 301
SER A 299
LEU A 300
LEU A 311
HIS A 286
 None
 1.41A 1y7iA-2x0fA:
5.6		 1y7iA-2x0fA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107
NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		PF04121
(Nup84_Nup100)
no annotation 		5 GLY B 972
ALA A 878
SER A 882
LEU B 976
LEU A 900
 None
 1.25A 1y7iA-3cqcB:
undetectable		 1y7iA-3cqcB:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 GLY A 614
ALA A 611
SER A 617
LEU A 620
LEU A 319
 None
 1.27A 1y7iA-3cttA:
undetectable		 1y7iA-3cttA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxp PUTATIVE ACYL-COA
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF01636
(APH) 		5 GLY A 248
SER A 216
LEU A 247
TRP A 242
HIS A 155
 None
 1.45A 1y7iA-3dxpA:
undetectable		 1y7iA-3dxpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6e ALANINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 229
ALA A 226
LEU A 243
LEU A 211
HIS A 355
 None
 1.23A 1y7iA-3e6eA:
undetectable		 1y7iA-3e6eA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed5 YFNB

(Bacillus
subtilis) 		PF13419
(HAD_2) 		5 GLY A  84
SER A  72
LEU A  87
TYR A  45
LEU A  29
 None
None
None
FMT  A 239 (-4.7A)
None
 1.21A 1y7iA-3ed5A:
3.5		 1y7iA-3ed5A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i08 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1

(Homo sapiens) 		PF07684
(NODP) 		5 GLY B1711
ALA B1708
SER B1712
LEU B1713
LEU B1704
 None
 1.42A 1y7iA-3i08B:
undetectable		 1y7iA-3i08B:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 COAT PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 5 GLY A  40
ALA A 149
SER A  41
LEU A 113
LEU A  61
 None
 1.15A 1y7iA-3j31A:
undetectable		 1y7iA-3j31A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwe MGLL PROTEIN

(Homo sapiens) 		PF12146
(Hydrolase_4) 		5 GLY A  60
ALA A  61
SER A 132
LEU A 215
HIS A 279
 F4P  A 314 ( 3.7A)
F4P  A 314 (-3.6A)
F4P  A 314 (-1.2A)
F4P  A 314 ( 4.1A)
F4P  A 314 (-4.3A)
 1.37A 1y7iA-3jweA:
18.6		 1y7iA-3jweA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkw PROTEIN SOPB

(Escherichia
coli) 		no annotation 5 GLY B 221
SER B 220
LEU B 224
PHE B 210
LEU B 261
 None
 1.28A 1y7iA-3mkwB:
undetectable		 1y7iA-3mkwB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mky PROTEIN SOPB

(Escherichia
coli) 		no annotation 5 GLY B 221
SER B 220
LEU B 224
PHE B 210
LEU B 261
 None
 1.23A 1y7iA-3mkyB:
undetectable		 1y7iA-3mkyB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkz PROTEIN SOPB

(Escherichia
coli) 		no annotation 5 GLY A 221
SER A 220
LEU A 224
PHE A 210
LEU A 261
 None
 1.29A 1y7iA-3mkzA:
undetectable		 1y7iA-3mkzA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		5 GLY A  54
SER A  23
LEU A  21
PHE A  92
LEU A 113
 None
ATP  A 763 (-3.2A)
None
None
None
 1.44A 1y7iA-3o8lA:
2.8		 1y7iA-3o8lA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 376
SER A 378
LEU A 377
LEU A 271
HIS A 165
 None
 1.29A 1y7iA-3ov3A:
undetectable		 1y7iA-3ov3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2w CADHERIN-2

(Mus musculus) 		PF00028
(Cadherin) 		5 GLY A  40
ALA A  43
LEU A  76
LEU A  60
HIS A  79
 None
 1.36A 1y7iA-3q2wA:
undetectable		 1y7iA-3q2wA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r44 FATTY ACYL COA
SYNTHETASE FADD13
(FATTY-ACYL-COA
SYNTHETASE)

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A  78
ALA A  79
LEU A  77
LEU A  46
HIS A 178
 None
 1.42A 1y7iA-3r44A:
undetectable		 1y7iA-3r44A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 GLY A 614
SER A 619
LEU A 622
TYR A 692
LEU A 716
 None
EDO  A 919 (-4.0A)
None
None
None
 1.28A 1y7iA-3s1sA:
2.5		 1y7iA-3s1sA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 GLY A  78
ALA A  79
LEU A  77
LEU A  46
HIS A 178
 None
 1.42A 1y7iA-3t5bA:
undetectable		 1y7iA-3t5bA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukf UDP-GALACTOPYRANOSE
MUTASE

(Aspergillus
fumigatus) 		PF13450
(NAD_binding_8) 		5 GLY A  16
ALA A  15
LEU A  20
TRP A  34
LEU A 229
 FDA  A 600 (-3.2A)
None
None
None
None
 1.20A 1y7iA-3ukfA:
undetectable		 1y7iA-3ukfA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1

(Yersinia pestis) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 GLY A  71
SER A 107
LEU A  70
LEU A 129
HIS A  95
 None
 1.19A 1y7iA-3zu4A:
3.4		 1y7iA-3zu4A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 GLY A 167
ALA A 166
LEU A 168
PHE A  81
LEU A  76
 None
None
None
None
EDO  A1514 (-4.2A)
 1.46A 1y7iA-4akoA:
undetectable		 1y7iA-4akoA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bko PUTATIVE REDUCTASE
BURPS305_1051

(Burkholderia
pseudomallei) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 GLY A  71
SER A 107
LEU A  70
LEU A 129
HIS A  95
 None
 1.13A 1y7iA-4bkoA:
3.4		 1y7iA-4bkoA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3y 3-KETOSTEROID
DEHYDROGENASE

(Rhodococcus
erythropolis) 		PF00890
(FAD_binding_2) 		5 GLY A 484
SER A 481
TYR A  92
TRP A  54
LEU A  77
 None
 1.43A 1y7iA-4c3yA:
undetectable		 1y7iA-4c3yA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccw CARBOXYL ESTERASE NP

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		5 GLY A  63
ALA A  64
SER A 130
LEU A 131
HIS A 274
 None
VKC  A1294 (-3.4A)
VKC  A1294 ( 3.8A)
None
VKC  A1294 ( 4.9A)
 0.65A 1y7iA-4ccwA:
17.9		 1y7iA-4ccwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		5 GLY A  56
ALA A  57
SER A  59
LEU A  58
LEU A  36
 None
 1.16A 1y7iA-4dcmA:
2.3		 1y7iA-4dcmA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 ALA A 328
LEU A 346
TRP A  97
PHE A 318
LEU A 310
 None
 1.34A 1y7iA-4dshA:
2.1		 1y7iA-4dshA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk1 PUTATIVE THIOREDOXIN
REDUCTASE

(Bacillus
anthracis) 		PF07992
(Pyr_redox_2) 		5 GLY C  15
ALA C  11
SER C  19
LEU C  16
LEU C  64
 None
None
None
None
MSO  C  68 ( 4.2A)
 1.03A 1y7iA-4fk1C:
undetectable		 1y7iA-4fk1C:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fle ESTERASE

(Yersinia
enterocolitica) 		PF05728
(UPF0227) 		5 GLY A  10
SER A  70
LEU A  71
LEU A 100
HIS A 173
 None
 1.00A 1y7iA-4fleA:
13.9		 1y7iA-4fleA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus) 		PF00501
(AMP-binding) 		5 GLY A  23
ALA A  22
LEU A  96
PHE A 219
LEU A 194
 None
 1.05A 1y7iA-4m46A:
3.2		 1y7iA-4m46A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4p ACYLNEURAMINATE
LYASE

(Mycoplasma
synoviae) 		PF00701
(DHDPS) 		5 GLY A 252
SER A 256
LEU A 253
TYR A 244
HIS A 286
 None
 1.46A 1y7iA-4n4pA:
undetectable		 1y7iA-4n4pA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 GLY A1689
ALA A1688
LEU A1709
TRP A2005
LEU A2016
 None
 1.05A 1y7iA-4o9xA:
undetectable		 1y7iA-4o9xA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opm LIPASE

(Acinetobacter
baumannii) 		PF12697
(Abhydrolase_6) 		5 GLY A  76
SER A 144
LEU A 145
LEU A 238
HIS A 298
 15P  A 401 ( 4.9A)
15P  A 401 (-3.6A)
15P  A 401 ( 4.9A)
15P  A 401 ( 4.9A)
None
 0.87A 1y7iA-4opmA:
19.4		 1y7iA-4opmA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 GLY A  81
SER A  48
LEU A  47
TYR A  51
LEU A 144
 None
 1.39A 1y7iA-4qk3A:
undetectable		 1y7iA-4qk3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1i AMINOBENZOYL-GLUTAMA
TE TRANSPORTER

(Neisseria
gonorrhoeae) 		PF03806
(ABG_transport) 		5 GLY A 171
ALA A 173
LEU A 172
LEU A 481
HIS A 167
 None
 1.17A 1y7iA-4r1iA:
undetectable		 1y7iA-4r1iA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7k HYPOTHETICAL PROTEIN
JHP0584

(Helicobacter
pylori) 		no annotation 5 GLY A 101
ALA A  83
TRP A  46
PHE A  74
LEU A  66
 None
 1.22A 1y7iA-4r7kA:
undetectable		 1y7iA-4r7kA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpc PUTATIVE ALPHA/BETA
HYDROLASE

(Desulfitobacterium
hafniense) 		PF12697
(Abhydrolase_6) 		5 GLY A  26
ALA A  27
SER A  93
LEU A  94
HIS A 238
 None
 0.79A 1y7iA-4rpcA:
14.3		 1y7iA-4rpcA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpc PUTATIVE ALPHA/BETA
HYDROLASE

(Desulfitobacterium
hafniense) 		PF12697
(Abhydrolase_6) 		5 GLY A  26
SER A  93
LEU A  94
TYR A 187
HIS A 238
 None
 1.27A 1y7iA-4rpcA:
14.3		 1y7iA-4rpcA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpc PUTATIVE ALPHA/BETA
HYDROLASE

(Desulfitobacterium
hafniense) 		PF12697
(Abhydrolase_6) 		5 GLY A  26
SER A  93
TYR A 187
PHE A 138
HIS A 238
 None
 1.34A 1y7iA-4rpcA:
14.3		 1y7iA-4rpcA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 GLY A  63
SER A  32
LEU A  30
PHE A 101
LEU A 122
 None
ATP  A 801 (-3.5A)
None
ATP  A 801 (-4.7A)
None
 1.36A 1y7iA-4u1rA:
3.9		 1y7iA-4u1rA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		5 GLY A  50
ALA A  52
SER A 148
LEU A 150
LEU A 364
 None
 1.21A 1y7iA-4uwqA:
undetectable		 1y7iA-4uwqA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x00 PUTATIVE HYDROLASE

(Burkholderia
cenocepacia) 		PF12697
(Abhydrolase_6) 		5 GLY A  42
SER A 112
LEU A 113
PHE A 172
HIS A 259
 None
GOL  A 308 (-3.5A)
GOL  A 308 ( 4.4A)
None
GOL  A 308 ( 4.5A)
 0.88A 1y7iA-4x00A:
21.9		 1y7iA-4x00A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgs PUTATIVE D-LACTATE
DEHYDROGENASE

(Chlamydomonas
reinhardtii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 339
TYR A 134
PHE A  85
LEU A 344
HIS A 335
 None
NAD  A1000 (-4.0A)
None
None
NAD  A1000 (-3.8A)
 1.41A 1y7iA-4zgsA:
6.1		 1y7iA-4zgsA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5caj UPF0246 PROTEIN YAAA

(Escherichia
coli) 		PF03883
(H2O2_YaaD) 		5 GLY A  -2
ALA A 158
SER A  -1
LEU A 159
HIS A 107
 None
 1.37A 1y7iA-5cajA:
undetectable		 1y7iA-5cajA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum) 		PF02055
(Glyco_hydro_30) 		5 GLY A  43
ALA A  42
SER A 291
LEU A  44
LEU A 272
 None
None
NA  A 601 (-4.3A)
None
None
 1.36A 1y7iA-5cxpA:
undetectable		 1y7iA-5cxpA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis SNURPORTIN-1

(Homo sapiens) 		PF11538
(Snurportin1) 		5 GLY C 159
ALA C 134
SER C 154
LEU C 156
LEU C 172
 None
 1.39A 1y7iA-5disC:
undetectable		 1y7iA-5disC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis SNURPORTIN-1

(Homo sapiens) 		PF11538
(Snurportin1) 		5 GLY C 159
ALA C 134
SER C 154
LEU C 156
TYR C 183
 None
 1.22A 1y7iA-5disC:
undetectable		 1y7iA-5disC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 GLY A 177
ALA A 175
LEU A 176
PHE A 381
LEU A 498
 None
 1.29A 1y7iA-5djwA:
undetectable		 1y7iA-5djwA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine leukemia
virus) 		PF00075
(RNase_H)
PF00078
(RVT_1) 		5 GLY A 305
LEU A 304
TYR A 344
TRP A 336
LEU A 324
 None
 1.44A 1y7iA-5dmqA:
undetectable		 1y7iA-5dmqA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evl BETA-LACTAMASE

(Chromobacterium
violaceum) 		PF00144
(Beta-lactamase) 		5 ALA A 251
LEU A 248
TYR A 235
LEU A 179
HIS A 256
 None
 1.19A 1y7iA-5evlA:
undetectable		 1y7iA-5evlA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		5 GLY A  23
ALA A  22
LEU A  96
PHE A 219
LEU A 194
 None
 0.99A 1y7iA-5gyzA:
3.9		 1y7iA-5gyzA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus) 		no annotation 5 GLY B 101
ALA B 102
SER B 185
LEU B 186
HIS B 349
 None
 0.92A 1y7iA-5hdfB:
20.1		 1y7iA-5hdfB:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hha PVDO

(Pseudomonas
aeruginosa) 		PF03781
(FGE-sulfatase) 		5 GLY A 213
ALA A 183
SER A 259
TYR A 177
PHE A 169
 None
 1.29A 1y7iA-5hhaA:
undetectable		 1y7iA-5hhaA:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hk8 PROBABLE
PHEOPHORBIDASE

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 GLY A  18
ALA A  19
SER A  87
TRP A 136
HIS A 239
 None
 0.99A 1y7iA-5hk8A:
33.8		 1y7iA-5hk8A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A  23
ALA A  22
LEU A  96
PHE A 219
LEU A 194
 None
 1.02A 1y7iA-5kyvA:
undetectable		 1y7iA-5kyvA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l08 CASPASE-8

(Homo sapiens) 		PF01335
(DED) 		5 GLY A  11
ALA A  41
LEU A  14
PHE A  45
LEU A  22
 None
 1.28A 1y7iA-5l08A:
undetectable		 1y7iA-5l08A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		5 GLY A 114
ALA A 112
LEU A 113
PHE A 127
LEU A 146
 None
 1.37A 1y7iA-5nckA:
undetectable		 1y7iA-5nckA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 5 GLY C 442
SER C 420
LEU C 443
PHE C 464
LEU C 472
 None
 1.44A 1y7iA-5o4gC:
undetectable		 1y7iA-5o4gC:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohx CYSTATHIONINE
BETA-SYNTHASE

(Apis mellifera) 		no annotation 5 GLY A 112
ALA A  82
LEU A 113
TYR A 122
LEU A 179
 None
 1.23A 1y7iA-5ohxA:
undetectable		 1y7iA-5ohxA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		5 GLY A 168
ALA A 171
LEU A 172
TYR A 123
HIS A  77
 None
None
None
None
TYR  A 401 (-3.5A)
 1.13A 1y7iA-5thhA:
undetectable		 1y7iA-5thhA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 GLY A 109
ALA A 110
SER A 188
PHE A 276
HIS A 445
 7BZ  A 601 (-3.0A)
7BZ  A 601 (-2.9A)
7BZ  A 601 (-1.4A)
7BZ  A 601 ( 4.9A)
7BZ  A 601 (-3.8A)
 1.03A 1y7iA-5thmA:
9.9		 1y7iA-5thmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vew GLUCAGON-LIKE
PEPTIDE 1
RECEPTOR,ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		5 GLY A 151
ALA A 153
SER A 155
LEU A 154
PHE A 195
 None
 1.44A 1y7iA-5vewA:
undetectable		 1y7iA-5vewA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE

(Marinomonas
mediterranea) 		no annotation 5 GLY A 375
ALA A 374
SER A  54
PHE A  37
LEU A  99
 None
 1.22A 1y7iA-5x32A:
undetectable		 1y7iA-5x32A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01058
(Oxidored_q6) 		5 GLY C  23
SER C  20
LEU C  21
LEU C  79
HIS C  28
 SF4  C 201 (-3.5A)
None
None
None
None
 1.35A 1y7iA-5xfaC:
undetectable		 1y7iA-5xfaC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn7 PUTATIVE RTX-TOXIN

(Vibrio
vulnificus) 		PF11647
(MLD) 		5 GLY A2847
ALA A2848
LEU A2808
PHE A2871
LEU A2805
 None
 1.42A 1y7iA-5xn7A:
undetectable		 1y7iA-5xn7A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z73 ALR0819 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 5 GLY A 309
ALA A 307
LEU A 311
PHE A 305
LEU A 384
 None
 1.26A 1y7iA-5z73A:
undetectable		 1y7iA-5z73A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 5 GLY A  88
ALA A  57
LEU A  89
TYR A  98
LEU A 155
 None
 1.17A 1y7iA-6c2hA:
undetectable		 1y7iA-6c2hA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR SECRETION
CHAPERONE
FLIS,FLAGELLIN

(Salmonella
enterica) 		no annotation 5 GLY B  55
ALA B  57
SER B  59
LEU B  58
LEU B  39
 None
 1.35A 1y7iA-6ch3B:
undetectable		 1y7iA-6ch3B:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoq DIPEPTIDYL PEPTIDASE
9

(Homo sapiens) 		no annotation 5 GLY A 733
ALA A 752
SER A 736
LEU A 737
LEU A 800
 None
 1.38A 1y7iA-6eoqA:
12.0		 1y7iA-6eoqA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 5 GLY A 758
ALA A 777
SER A 761
LEU A 762
LEU A 825
 None
 1.35A 1y7iA-6eotA:
10.7		 1y7iA-6eotA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum) 		no annotation 5 GLY A  38
SER A  41
TYR A 354
PHE A  33
LEU A 358
 None
 1.27A 1y7iA-6fhvA:
undetectable		 1y7iA-6fhvA:
15.85