SIMILAR PATTERNS OF AMINO ACIDS FOR 1Y4L_B_SVRB301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aok VIPOXIN COMPLEX

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		5 LEU B   2
GLY B  30
TYR B  52
PRO B  68
LYS B  69
 None
ACT  B 134 (-3.7A)
None
None
None
 0.75A 1y4lA-1aokB:
19.8		 1y4lA-1aokB:
49.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aol GP70

(Murine leukemia
virus) 		PF00429
(TLV_coat) 		5 GLY A  20
GLY A  52
LEU A  58
GLY A  57
PRO A 218
 None
 1.23A 1y4lA-1aolA:
undetectable		 1y4lA-1aolA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aur CARBOXYLESTERASE

(Pseudomonas
fluorescens) 		PF02230
(Abhydrolase_2) 		5 GLY A  24
GLY A  22
LEU A  20
GLY A 112
PRO A 143
 None
PMS  A 801 ( 3.9A)
None
None
None
 1.22A 1y4lA-1aurA:
undetectable		 1y4lA-1aurA:
17.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpq PHOSPHOLIPASE A2

(Bos taurus) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
GLY A  32
TYR A  52
LYS A  53
PRO A  68
 None
CA  A 124 (-4.2A)
None
None
None
 0.99A 1y4lA-1bpqA:
17.8		 1y4lA-1bpqA:
38.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		5 LEU E  20
GLY E 119
LEU E  71
GLY E  82
PRO E  58
 None
 1.09A 1y4lA-1cziE:
undetectable		 1y4lA-1cziE:
16.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0z PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
GLY A  30
GLY A  32
TYR A  52
PRO A  63
 None
 1.02A 1y4lA-1g0zA:
16.7		 1y4lA-1g0zA:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1god PROTEIN
(PHOSPHOLIPASE A2)

(Cerrophidion
godmani) 		PF00068
(Phospholip_A2_1) 		5 GLY A  23
LYS A  49
TYR A  52
PRO A  68
LYS A  69
 None
 0.70A 1y4lA-1godA:
21.8		 1y4lA-1godA:
80.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Leishmania
mexicana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU A  97
GLY A 122
LEU A 113
GLY A 112
LYS A  89
 None
None
NBD  A 361 (-4.7A)
NBD  A 361 (-3.6A)
None
 1.17A 1y4lA-1gyqA:
undetectable		 1y4lA-1gyqA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		5 LEU A 183
GLY A  23
GLY A  21
LEU A  19
GLY A  80
 3OH  A 300 (-4.3A)
None
3OH  A 300 (-3.6A)
None
None
 1.08A 1y4lA-1m33A:
undetectable		 1y4lA-1m33A:
16.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8r PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
GLY A  30
GLY A  32
TYR A  52
PRO A  68
 None
BU1  A1002 (-4.3A)
CD  A1001 (-3.9A)
None
None
 1.25A 1y4lA-1m8rA:
19.8		 1y4lA-1m8rA:
50.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		5 LEU A1002
GLY A1023
ARG A1034
TYR A1052
LYS A1069
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.1A)
None
None
None
 0.83A 1y4lA-1mc2A:
23.8		 1y4lA-1mc2A:
75.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		8 LEU A1002
GLY A1023
GLY A1030
GLY A1033
ARG A1034
LYS A1049
TYR A1052
LYS A1070
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.1A)
IPA  A1135 ( 4.4A)
None
None
None
None
None
 0.62A 1y4lA-1mc2A:
23.8		 1y4lA-1mc2A:
75.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n28 PHOSPHOLIPASE A2,
MEMBRANE ASSOCIATED

(Homo sapiens) 		no annotation 5 LEU B   2
GLY B  22
GLY B  29
GLY B  32
TYR B  51
 None
None
CA  B 125 (-4.4A)
CA  B 125 ( 4.7A)
None
 1.02A 1y4lA-1n28B:
21.1		 1y4lA-1n28B:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyt SHIKIMATE
5-DEHYDROGENASE

(Escherichia
coli) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 GLY A 103
GLY A 105
LEU A 241
GLY A 239
ARG A 112
 None
None
NAP  A1401 (-4.0A)
None
None
 1.10A 1y4lA-1nytA:
undetectable		 1y4lA-1nytA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5z FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE

(Thermotoga
maritima) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A  23
GLY A 187
GLY A 148
LEU A 146
GLY A 145
 None
None
None
SO4  A 501 (-4.2A)
UNL  A 701 ( 3.6A)
 0.88A 1y4lA-1o5zA:
undetectable		 1y4lA-1o5zA:
15.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1po8 PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
GLY A  30
GLY A  32
TYR A  52
PRO A  63
 None
SHV  A 122 ( 3.7A)
NA  A 121 (-3.3A)
None
None
 1.08A 1y4lA-1po8A:
16.8		 1y4lA-1po8A:
39.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2

(Crotalus atrox) 		no annotation 5 LEU R   2
GLY R  18
TYR R  52
PRO R  68
LYS R  69
 None
 1.09A 1y4lA-1pp2R:
19.9		 1y4lA-1pp2R:
45.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 LEU A 155
GLY A 151
LEU A  79
GLY A  78
PRO A 219
 None
 1.20A 1y4lA-1rf5A:
undetectable		 1y4lA-1rf5A:
16.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vpi PHOSPHOLIPASE A2
INHIBITOR

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
GLY A  30
TYR A  52
PRO A  68
LYS A  69
 None
 0.84A 1y4lA-1vpiA:
20.7		 1y4lA-1vpiA:
51.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A  32
GLY A 190
GLY A 151
LEU A 149
GLY A 148
 None
KCX  A 188 ( 4.1A)
KCX  A 188 ( 4.1A)
PD8  A1421 ( 4.4A)
PD8  A1421 (-4.0A)
 0.93A 1y4lA-1w78A:
undetectable		 1y4lA-1w78A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yck PEPTIDOGLYCAN
RECOGNITION PROTEIN

(Homo sapiens) 		PF01510
(Amidase_2) 		5 GLY A 138
GLY A 134
LEU A 130
GLY A 129
PRO A 170
 None
 1.13A 1y4lA-1yckA:
undetectable		 1y4lA-1yckA:
17.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zl7 HYPOTENSIVE
PHOSPHOLIPASE A2

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 GLY A  29
GLY A  32
TYR A  51
PRO A  59
LYS A  60
 None
CA  A1001 (-3.4A)
None
None
None
 1.13A 1y4lA-1zl7A:
20.3		 1y4lA-1zl7A:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zl7 HYPOTENSIVE
PHOSPHOLIPASE A2

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
GLY A  29
GLY A  32
PRO A  59
LYS A  60
 None
None
CA  A1001 (-3.4A)
None
None
 1.14A 1y4lA-1zl7A:
20.3		 1y4lA-1zl7A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 LEU A  63
GLY A  66
GLY A 197
ARG A 203
PRO A  42
 None
 0.98A 1y4lA-2fafA:
undetectable		 1y4lA-2fafA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fp7 GENOME POLYPROTEIN

(West Nile virus) 		PF00949
(Peptidase_S7) 		5 GLY B 153
GLY B 151
LEU B 149
GLY B 136
TYR B 130
 None
 1.25A 1y4lA-2fp7B:
undetectable		 1y4lA-2fp7B:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnl GLUTATHIONE
S-TRANSFERASE 1

(Onchocerca
volvulus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A  48
GLY A 100
LEU A 102
GLY A 103
LYS A 173
 None
 1.25A 1y4lA-2hnlA:
undetectable		 1y4lA-2hnlA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ij9 URIDYLATE KINASE

(Archaeoglobus
fulgidus) 		PF00696
(AA_kinase) 		5 LEU A  12
GLY A   9
GLY A  40
GLY A 108
ARG A  71
 None
SO4  A 301 (-3.3A)
SO4  A 301 (-3.4A)
None
None
 1.17A 1y4lA-2ij9A:
undetectable		 1y4lA-2ij9A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 LEU A 585
GLY A 686
GLY A 683
GLY A 680
ARG A 679
 None
 1.23A 1y4lA-2ipcA:
undetectable		 1y4lA-2ipcA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		5 LEU A 223
GLY A 328
GLY A 330
LEU A 332
GLY A 343
 None
None
ACJ  A1465 (-3.9A)
ACJ  A1465 (-4.2A)
ACJ  A1465 ( 4.6A)
 1.21A 1y4lA-2ivdA:
undetectable		 1y4lA-2ivdA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j76 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4B

(Homo sapiens) 		PF00076
(RRM_1) 		5 GLY E  43
LEU E   5
GLY E  45
ARG E  30
PRO E  35
 None
 1.26A 1y4lA-2j76E:
undetectable		 1y4lA-2j76E:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 GLY A 198
GLY A 197
LEU A 195
GLY A  72
ARG A  73
 None
 1.22A 1y4lA-2nsmA:
undetectable		 1y4lA-2nsmA:
12.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ph4 ZHAOERMIATOXIN

(Protobothrops
mangshanensis) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
TYR A  52
PRO A  68
LYS A  69
LYS A  70
 PEG  A 401 ( 4.5A)
None
None
None
None
 1.09A 1y4lA-2ph4A:
22.4		 1y4lA-2ph4A:
74.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ph4 ZHAOERMIATOXIN

(Protobothrops
mangshanensis) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
GLY A  30
TYR A  52
PRO A  68
LYS A  70
 None
PEG  A 401 ( 4.5A)
None
None
None
 0.60A 1y4lA-2ph4A:
22.4		 1y4lA-2ph4A:
74.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl5 HOMOSERINE
O-ACETYLTRANSFERASE

(Leptospira
interrogans) 		PF00561
(Abhydrolase_1) 		5 GLY A 206
GLY A 119
LEU A 108
GLY A 106
PRO A 112
 None
None
GOL  A 400 (-4.0A)
GOL  A 400 (-3.3A)
None
 1.23A 1y4lA-2pl5A:
undetectable		 1y4lA-2pl5A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 LEU A 782
GLY A 687
LEU A 193
GLY A 192
TYR A 698
 None
 0.88A 1y4lA-2po4A:
undetectable		 1y4lA-2po4A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		5 GLY A 516
LEU A 547
ARG A 542
TYR A 541
PRO A 456
 None
 1.23A 1y4lA-2pziA:
undetectable		 1y4lA-2pziA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1c RECOMBINATION
PROTEIN RECR

(Deinococcus
radiodurans) 		PF02132
(RecR)
PF13662
(Toprim_4) 		5 LEU A 107
GLY A 142
GLY A 147
LEU A 152
PRO A 119
 None
 1.15A 1y4lA-2v1cA:
undetectable		 1y4lA-2v1cA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 GLY A  84
GLY A  82
ARG A 170
PRO A  57
LYS A  56
 None
 0.97A 1y4lA-2wfiA:
undetectable		 1y4lA-2wfiA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wj3 1-H-3-HYDROXY-4-OXOQ
UINALDINE
2,4-DIOXYGENASE

(Paenarthrobacter
nitroguajacolicus) 		PF00561
(Abhydrolase_1) 		5 GLY A  35
LEU A 143
GLY A 189
TYR A 196
PRO A 132
 None
 1.21A 1y4lA-2wj3A:
undetectable		 1y4lA-2wj3A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		5 LEU A 222
GLY A 214
GLY A 216
GLY A 250
PRO A 445
 ZKD  A1569 (-4.4A)
None
None
None
None
 1.17A 1y4lA-2xgoA:
undetectable		 1y4lA-2xgoA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A  45
GLY A 211
LEU A 213
GLY A 225
LYS A  26
 None
 1.19A 1y4lA-2zecA:
undetectable		 1y4lA-2zecA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cn7 CARBOXYLESTERASE

(Pseudomonas
aeruginosa) 		PF02230
(Abhydrolase_2) 		6 GLY A  23
GLY A  21
LEU A  19
GLY A 111
TYR A 140
PRO A 142
 None
 1.19A 1y4lA-3cn7A:
undetectable		 1y4lA-3cn7A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8u TAPASIN

(Homo sapiens) 		PF07654
(C1-set) 		5 GLY B 317
GLY B 315
GLY B 357
TYR B 360
PRO B 348
 None
 1.11A 1y4lA-3f8uB:
undetectable		 1y4lA-3f8uB:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		5 LEU A 343
GLY A 289
GLY A 264
LEU A 268
GLY A 273
 None
LLP  A 288 ( 2.4A)
None
None
None
 1.25A 1y4lA-3fcrA:
undetectable		 1y4lA-3fcrA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8y SUSD/RAGB-ASSOCIATED
ESTERASE-LIKE
PROTEIN

(Bacteroides
vulgatus) 		PF12715
(Abhydrolase_7) 		5 LEU A 141
GLY A 254
LEU A 257
GLY A 145
ARG A 148
 None
None
None
EDO  A   4 (-3.5A)
PEG  A  13 ( 3.5A)
 1.17A 1y4lA-3g8yA:
undetectable		 1y4lA-3g8yA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9k CAPSULE BIOSYNTHESIS
PROTEIN CAPD

(Bacillus
anthracis) 		no annotation 5 LEU L 210
GLY L  84
GLY L  92
GLY L 131
LYS L 212
 None
 1.19A 1y4lA-3g9kL:
undetectable		 1y4lA-3g9kL:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 LEU A 335
GLY A 122
GLY A  58
LEU A 380
GLY A 381
 None
 1.20A 1y4lA-3lscA:
undetectable		 1y4lA-3lscA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwj ATSK2

(Arabidopsis
thaliana) 		PF01202
(SKI) 		5 LEU A 256
GLY A 108
GLY A 110
LEU A 103
GLY A 115
 None
 1.21A 1y4lA-3nwjA:
undetectable		 1y4lA-3nwjA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvd CAPSID

(Norwalk virus) 		PF08435
(Calici_coat_C) 		5 LEU A 415
GLY A 321
LEU A 323
GLY A 324
PRO A 261
 None
 1.21A 1y4lA-3pvdA:
undetectable		 1y4lA-3pvdA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE

(Yersinia pestis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A  32
GLY A 190
GLY A 151
LEU A 149
GLY A 148
 None
 1.01A 1y4lA-3pyzA:
undetectable		 1y4lA-3pyzA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8e HYPOTHETICAL SUGAR
KINASE

(Cytophaga
hutchinsonii) 		PF00480
(ROK) 		5 GLY A 249
GLY A 248
LEU A 246
GLY A 281
LYS A 263
 None
 1.23A 1y4lA-3r8eA:
undetectable		 1y4lA-3r8eA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 GLY A 534
GLY A 526
ARG A 566
LYS A 472
LYS A 488
 None
 1.14A 1y4lA-3uk8A:
undetectable		 1y4lA-3uk8A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcs ERYTHROAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 GLY A 235
GLY A 124
LEU A 126
GLY A 128
ARG A  69
 NAG  A1005 ( 3.8A)
MAN  A1004 (-3.5A)
MAN  A1004 (-4.2A)
None
None
 1.23A 1y4lA-3wcsA:
undetectable		 1y4lA-3wcsA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9

(Saccharomyces
cerevisiae) 		PF03452
(Anp1) 		5 GLY A 339
GLY A 337
LEU A 333
GLY A 335
LYS A 344
 None
 1.20A 1y4lA-3zf8A:
undetectable		 1y4lA-3zf8A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aov ISOCITRATE
DEHYDROGENASE [NADP]

(Desulfotalea
psychrophila) 		PF00180
(Iso_dh) 		5 LEU A 328
GLY A 306
LEU A  43
GLY A  44
PRO A  23
 None
NAP  A1403 (-3.0A)
None
None
None
 0.99A 1y4lA-4aovA:
undetectable		 1y4lA-4aovA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayn FACTOR H-BINDING
PROTEIN

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		5 LEU A 291
GLY A 242
LEU A 258
GLY A 244
TYR A 217
 None
 1.23A 1y4lA-4aynA:
undetectable		 1y4lA-4aynA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE SUBUNIT
RPT4

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU L 231
GLY L 182
GLY L 184
GLY L 356
ARG L 357
 None
 1.24A 1y4lA-4cr4L:
undetectable		 1y4lA-4cr4L:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg5 PHOSPHOGLYCERATE
KINASE

(Staphylococcus
aureus) 		PF00162
(PGK) 		5 LEU A 387
GLY A 152
GLY A 374
GLY A 352
LYS A 206
 None
 1.03A 1y4lA-4dg5A:
undetectable		 1y4lA-4dg5A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Zea mays) 		PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH) 		5 LEU A 882
GLY A 862
LEU A 359
GLY A 356
TYR A 597
 None
 1.24A 1y4lA-4ft2A:
undetectable		 1y4lA-4ft2A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Zea mays) 		PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH) 		5 LEU A 882
GLY A 866
GLY A 862
LEU A 359
GLY A 356
 None
 1.16A 1y4lA-4ft2A:
undetectable		 1y4lA-4ft2A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4heq FLAVODOXIN

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1) 		5 LEU A  74
GLY A   9
GLY A  56
LEU A  54
GLY A  89
 None
 1.19A 1y4lA-4heqA:
undetectable		 1y4lA-4heqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens) 		PF00491
(Arginase) 		5 LEU A  37
GLY A  51
GLY A  12
GLY A  98
LYS A  39
 None
 1.10A 1y4lA-4hxqA:
undetectable		 1y4lA-4hxqA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		5 LEU A  39
GLY A  19
LEU A 137
GLY A 136
TYR A 155
 None
FAD  A 601 (-3.4A)
None
None
None
 1.04A 1y4lA-4k5rA:
undetectable		 1y4lA-4k5rA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		5 LEU A 579
GLY A 276
LEU A 533
GLY A 534
ARG A 535
 None
 1.02A 1y4lA-4madA:
undetectable		 1y4lA-4madA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mes THIAMINE TRANSPORTER
THIT

(Lactococcus
lactis) 		PF09515
(Thia_YuaJ) 		5 LEU A  10
GLY A  59
GLY A  56
LEU A  53
GLY A  96
 PG4  A 211 (-4.4A)
None
None
None
None
 1.03A 1y4lA-4mesA:
undetectable		 1y4lA-4mesA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmw PIMELYL-[ACYL-CARRIE
R PROTEIN] METHYL
ESTER ESTERASE

(Salmonella
enterica) 		PF00561
(Abhydrolase_1) 		5 LEU A 183
GLY A  23
GLY A  21
LEU A  19
GLY A  80
 None
None
CL  A 301 ( 4.0A)
None
None
 1.16A 1y4lA-4nmwA:
undetectable		 1y4lA-4nmwA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqr CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 LEU A 257
GLY A 252
LEU A 249
ARG A 384
PRO A 396
 None
 1.15A 1y4lA-4oqrA:
undetectable		 1y4lA-4oqrA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 LEU A 208
GLY A  61
GLY A  89
LEU A 142
ARG A  84
 None
 1.00A 1y4lA-4p0vA:
undetectable		 1y4lA-4p0vA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 5 LEU A 517
LEU A 559
GLY A 525
ARG A 497
LYS A 480
 None
 1.15A 1y4lA-4ru5A:
undetectable		 1y4lA-4ru5A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 LEU P 452
GLY P 484
GLY P 486
GLY P 488
TYR P 539
 None
 1.11A 1y4lA-4s2tP:
undetectable		 1y4lA-4s2tP:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		5 LEU A 558
GLY A 524
GLY A 523
GLY A 520
LYS A 255
 None
 1.13A 1y4lA-4uooA:
undetectable		 1y4lA-4uooA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utg SUGAR KINASE

(Burkholderia
pseudomallei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 307
GLY A 115
GLY A 299
GLY A  19
LYS A 268
 None
ANP  A 399 ( 3.0A)
ANP  A 399 (-3.7A)
CL  A 401 (-3.5A)
CL  A 402 ( 4.0A)
 1.10A 1y4lA-4utgA:
undetectable		 1y4lA-4utgA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 GLY A 264
GLY A 372
LEU A 352
GLY A 375
ARG A 369
 None
 1.20A 1y4lA-4w1wA:
undetectable		 1y4lA-4w1wA:
12.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		9 LEU A   2
GLY A  22
GLY A  29
GLY A  32
ARG A  33
LYS A  48
TYR A  51
PRO A  59
LYS A  61
 None
None
None
None
None
ZN  A 201 ( 4.2A)
None
None
None
 0.83A 1y4lA-4wtbA:
24.0		 1y4lA-4wtbA:
94.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 LEU A 237
GLY A 204
GLY A 207
LEU A 113
ARG A 275
PRO A 242
 None
 1.39A 1y4lA-4x3fA:
undetectable		 1y4lA-4x3fA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		5 GLY A 351
GLY A 349
LEU A 202
GLY A 201
TYR A  53
 None
 1.08A 1y4lA-5aexA:
undetectable		 1y4lA-5aexA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		5 GLY A 352
GLY A 349
LEU A 202
GLY A 201
TYR A  53
 None
 0.93A 1y4lA-5aexA:
undetectable		 1y4lA-5aexA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		5 GLY A 304
GLY A 302
ARG A 221
TYR A 222
PRO A  84
 EDO  A 807 ( 3.8A)
None
EDO  A 808 ( 4.8A)
None
None
 1.24A 1y4lA-5bv9A:
undetectable		 1y4lA-5bv9A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Catenulispora
acidiphila) 		no annotation 5 LEU A 164
GLY A 123
GLY A 119
LEU A 116
GLY A 114
 None
None
None
SAM  A 301 (-4.0A)
SAM  A 301 ( 4.6A)
 1.20A 1y4lA-5bw4A:
undetectable		 1y4lA-5bw4A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsh CSM6

(Thermus
thermophilus) 		PF09670
(Cas_Cas02710) 		5 LEU A 367
GLY A 407
GLY A 410
GLY A 414
ARG A 415
 None
 1.06A 1y4lA-5fshA:
undetectable		 1y4lA-5fshA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae) 		PF00890
(FAD_binding_2) 		5 LEU A 346
GLY A 307
GLY A 305
LEU A 146
GLY A 147
 None
 1.18A 1y4lA-5glgA:
undetectable		 1y4lA-5glgA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsz NUCLEOID OCCLUSION
FACTOR SLMA

(Klebsiella
pneumoniae) 		PF00440
(TetR_N) 		5 GLY A  97
GLY A  99
LEU A 105
GLY A 104
ARG A 107
 None
 1.18A 1y4lA-5hszA:
undetectable		 1y4lA-5hszA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		5 GLY A 442
GLY A 444
LEU A 446
GLY A 488
ARG A 507
 None
 1.07A 1y4lA-5iv8A:
undetectable		 1y4lA-5iv8A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY PROTEIN
LPTD

(Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04453
(OstA_C) 		5 GLY A 419
GLY A 421
LEU A 423
GLY A 465
ARG A 484
 None
 1.05A 1y4lA-5iv9A:
undetectable		 1y4lA-5iv9A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 LEU L 412
GLY L 250
GLY L 248
GLY L 443
ARG L 447
 None
None
FAD  L 503 (-3.1A)
FAD  L 503 (-3.3A)
None
 1.20A 1y4lA-5jfcL:
undetectable		 1y4lA-5jfcL:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 GLY A 627
LEU A 535
GLY A 534
ARG A 398
PRO A 622
 None
 1.25A 1y4lA-5m60A:
undetectable		 1y4lA-5m60A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mog PHYTOENE
DEHYDROGENASE,
CHLOROPLASTIC/CHROMO
PLASTIC

(Oryza sativa) 		PF01593
(Amino_oxidase) 		5 GLY A 548
LEU A 546
GLY A 543
TYR A 532
PRO A 517
 None
 1.16A 1y4lA-5mogA:
undetectable		 1y4lA-5mogA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		5 GLY N 372
GLY N 407
LEU N 448
GLY N 449
PRO N 391
 None
 0.81A 1y4lA-5mpdN:
undetectable		 1y4lA-5mpdN:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no4 30S RIBOSOMAL
PROTEIN S3

(Escherichia
coli) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		5 LEU C 111
GLY C 148
ARG C 136
PRO C 109
LYS C 108
 None
 1.24A 1y4lA-5no4C:
undetectable		 1y4lA-5no4C:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syn ACYL-PROTEIN
THIOESTERASE 2

(Homo sapiens) 		PF02230
(Abhydrolase_2) 		5 LEU A  78
GLY A  34
GLY A  32
LEU A  30
GLY A 120
 71T  A 301 ( 3.7A)
None
None
None
None
 0.87A 1y4lA-5synA:
undetectable		 1y4lA-5synA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3e TRANSCRIPTIONAL
REGULATOR

(Porphyromonas
gingivalis) 		no annotation 5 LEU A  80
GLY A  59
GLY A  83
LEU A  16
GLY A  15
 None
 1.24A 1y4lA-5v3eA:
undetectable		 1y4lA-5v3eA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 5 GLY A 407
GLY A 445
LEU A 422
GLY A 423
ARG A 427
 None
CL  A 505 ( 3.7A)
None
None
None
 1.21A 1y4lA-5x4jA:
undetectable		 1y4lA-5x4jA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei) 		no annotation 5 LEU A 273
GLY A 268
LEU A 265
ARG A 402
PRO A 414
 None
 1.11A 1y4lA-5ysmA:
undetectable		 1y4lA-5ysmA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal RISC-LOADING COMPLEX
SUBUNIT TARBP2

(Homo sapiens) 		no annotation 5 LEU B 298
GLY B 291
GLY B 349
ARG B 344
TYR B 311
 None
 1.08A 1y4lA-5zalB:
undetectable		 1y4lA-5zalB:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bvg PROTEIN-N(PI)-PHOSPH
OHISTIDINE-SUGAR
PHOSPHOTRANSFERASE
(ENZYME II OF THE
PHOSPHOTRANSFERASE
SYSTEM) (PTS SYSTEM
GLUCOSE-SPECIFIC
IIBC COMPONENT)

(Bacillus cereus) 		no annotation 5 LEU A  16
GLY A 150
GLY A 146
GLY A 142
PRO A 246
 None
 1.24A 1y4lA-6bvgA:
undetectable		 1y4lA-6bvgA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 7 LEU A   2
GLY A  23
GLY A  30
GLY A  33
ARG A  34
LYS A  49
TYR A  52
 PE4  A 201 ( 4.3A)
PE4  A 201 ( 3.9A)
PE4  A 201 ( 3.6A)
None
None
None
None
 1.14A 1y4lA-6ce2A:
23.8		 1y4lA-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 7 LEU A   2
GLY A  23
GLY A  30
GLY A  33
LYS A  49
TYR A  52
PRO A  68
 PE4  A 201 ( 4.3A)
PE4  A 201 ( 3.9A)
PE4  A 201 ( 3.6A)
None
None
None
None
 0.65A 1y4lA-6ce2A:
23.8		 1y4lA-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 7 LEU A   2
GLY A  23
GLY A  30
LEU A  32
GLY A  33
LYS A  49
TYR A  52
 PE4  A 201 ( 4.3A)
PE4  A 201 ( 3.9A)
PE4  A 201 ( 3.6A)
None
None
None
None
 1.12A 1y4lA-6ce2A:
23.8		 1y4lA-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 6 LEU A   5
GLY A  23
GLY A  30
LEU A  32
GLY A  33
LYS A  49
 PE4  A 201 ( 4.7A)
PE4  A 201 ( 3.9A)
PE4  A 201 ( 3.6A)
None
None
None
 1.38A 1y4lA-6ce2A:
23.8		 1y4lA-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 5 LEU A 106
GLY A  13
GLY A  17
GLY A 325
LYS A 108
 None
FAD  A 502 ( 4.8A)
None
None
None
 0.98A 1y4lA-6cmzA:
undetectable		 1y4lA-6cmzA:
17.24