SIMILAR PATTERNS OF AMINO ACIDS FOR 1Y1P_A_ACTA803

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 HIS A 381
GLU A 374
GLN A 446
PHE A 370
 None
 1.32A 1y1pA-1tuoA:
0.0		 1y1pA-1tuoA:
23.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y1p ALDEHYDE REDUCTASE
II

(Sporidiobolus
salmonicolor) 		PF01370
(Epimerase) 		4 HIS A  27
GLU A  30
GLN A  31
PHE A 214
 ACT  A 803 (-3.7A)
ACT  A 803 (-4.7A)
ACT  A 803 (-4.3A)
ACT  A 803 (-4.5A)
 0.00A 1y1pA-1y1pA:
63.4		 1y1pA-1y1pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0n 2-ON-2 HEMOGLOBIN

(Arabidopsis
thaliana) 		PF01152
(Bac_globin) 		4 HIS A 105
GLU A 109
GLN A 106
PHE A 142
 None
 1.44A 1y1pA-4c0nA:
0.0		 1y1pA-4c0nA:
17.12