SIMILAR PATTERNS OF AMINO ACIDS FOR 1Y0X_X_T44X500_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cun PROTEIN (ALPHA
SPECTRIN)

(Gallus gallus) 		PF00435
(Spectrin) 		4 ILE A 147
SER A 137
LEU A 214
ASN A 217
 None
 1.11A 1y0xX-1cunA:
undetectable		 1y0xX-1cunA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ

(Sinorhizobium
meliloti) 		PF00072
(Response_reg) 		4 ILE A 112
SER A  18
LEU A  23
ASN A  26
 None
 1.11A 1y0xX-1dbwA:
0.0		 1y0xX-1dbwA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcq PYK2-ASSOCIATED
PROTEIN BETA

(Mus musculus) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		4 ILE A 387
SER A 312
LEU A 316
ASN A 319
 None
 0.95A 1y0xX-1dcqA:
0.0		 1y0xX-1dcqA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivm LYSOZYME M

(Mus musculus) 		PF00062
(Lys) 		4 ILE A  93
ARG A  14
LEU A  12
ASN A  15
 None
 1.06A 1y0xX-1ivmA:
0.0		 1y0xX-1ivmA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ILE A 810
SER A 721
LEU A 773
ASN A 774
 None
 1.13A 1y0xX-1kqfA:
0.0		 1y0xX-1kqfA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kw2 VITAMIN D-BINDING
PROTEIN

(Homo sapiens) 		PF00273
(Serum_albumin)
PF09164
(VitD-bind_III) 		4 ILE A 261
SER A 234
ARG A 232
LEU A 262
 None
 1.20A 1y0xX-1kw2A:
0.6		 1y0xX-1kw2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 ILE A 159
ARG A 146
LEU A 140
ASN A 141
 None
 1.10A 1y0xX-1ldjA:
1.5		 1y0xX-1ldjA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ls4 APOLIPOPHORIN-III

(Locusta
migratoria) 		no annotation 4 ILE A  88
ARG A  82
LEU A  84
ASN A  85
 None
 1.10A 1y0xX-1ls4A:
undetectable		 1y0xX-1ls4A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 ILE A 298
SER A 388
ARG A 335
LEU A 337
 None
 1.17A 1y0xX-1mb9A:
0.0		 1y0xX-1mb9A:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ILE A 221
SER A 260
ARG A 262
LEU A 276
 None
IH5  A 600 ( 4.0A)
None
IH5  A 600 (-4.0A)
 0.21A 1y0xX-1navA:
37.3		 1y0xX-1navA:
83.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ
HYPOTHETICAL PROTEIN
PA3008

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF03846
(SulA)
PF12327
(FtsZ_C) 		4 ILE X 102
SER A 272
ARG X  76
LEU X 103
 None
 1.06A 1y0xX-1ofuX:
undetectable		 1y0xX-1ofuX:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxe NEURAL ZINC FINGER
TRANSCRIPTION FACTOR
1

(Rattus
norvegicus) 		PF01530
(zf-C2HC) 		4 ILE A  54
SER A  18
ARG A  39
LEU A  41
 ZN  A  64 ( 4.7A)
None
None
None
 1.20A 1y0xX-1pxeA:
undetectable		 1y0xX-1pxeA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0a ZN(II)-RESPONSIVE
REGULATOR OF ZNTA

(Escherichia
coli) 		PF09278
(MerR-DNA-bind) 		4 ILE A  70
SER A  60
ARG A  65
LEU A  67
 None
 1.10A 1y0xX-1q0aA:
undetectable		 1y0xX-1q0aA:
17.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ILE A 275
SER A 314
ARG A 316
LEU A 330
ASN A 331
 None
G24  A 462 ( 4.7A)
None
G24  A 462 ( 3.9A)
None
 0.53A 1y0xX-1q4xA:
37.5		 1y0xX-1q4xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 ILE A 122
SER A 134
LEU A 126
ASN A 123
 None
 1.11A 1y0xX-1rt8A:
undetectable		 1y0xX-1rt8A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj5 CONSERVED
HYPOTHETICAL PROTEIN
TM0160

(Thermotoga
maritima) 		PF02577
(DNase-RNase) 		4 ILE A 139
SER A 130
ARG A   2
LEU A  31
 None
 0.89A 1y0xX-1sj5A:
undetectable		 1y0xX-1sj5A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq5 PANTOTHENATE KINASE

(Escherichia
coli) 		PF00485
(PRK) 		4 ILE A1066
ARG A1060
LEU A1062
ASN A1063
 None
 1.12A 1y0xX-1sq5A:
undetectable		 1y0xX-1sq5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ILE A 100
ARG A  87
LEU A  99
ASN A  98
 None
 1.20A 1y0xX-1w99A:
undetectable		 1y0xX-1w99A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 ILE B 222
SER B 164
LEU B 209
ASN B 211
 None
 1.15A 1y0xX-1wytB:
undetectable		 1y0xX-1wytB:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 ILE A   6
SER A  68
LEU A  39
ASN A  42
 None
 1.04A 1y0xX-1yrgA:
undetectable		 1y0xX-1yrgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ILE A 154
SER A 185
ARG A 186
LEU A 155
 None
 1.17A 1y0xX-1yx2A:
undetectable		 1y0xX-1yx2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ILE A 198
ARG A 676
LEU A 740
ASN A 736
 None
 1.03A 1y0xX-2ivfA:
undetectable		 1y0xX-2ivfA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kay PROTEIN S100-A5

(Homo sapiens) 		PF01023
(S_100) 		4 ILE A  38
SER A  20
ARG A  22
LEU A  34
 None
CA  A 186 (-3.9A)
None
None
 1.02A 1y0xX-2kayA:
undetectable		 1y0xX-2kayA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ke7 ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF00536
(SAM_1) 		4 ILE A 871
SER A 861
ARG A 866
LEU A 868
 None
 1.04A 1y0xX-2ke7A:
undetectable		 1y0xX-2ke7A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfy HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN F

(Homo sapiens) 		no annotation 4 ILE A  36
SER A  88
ARG A  90
LEU A  61
 None
 1.12A 1y0xX-2kfyA:
undetectable		 1y0xX-2kfyA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwx MATRIX PROTEIN 2

(Influenza A
virus) 		PF00599
(Flu_M2) 		4 ILE A  39
SER A  50
ARG A  45
LEU A  43
 None
 1.01A 1y0xX-2kwxA:
undetectable		 1y0xX-2kwxA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kym BUD EMERGENCE
PROTEIN 1

(Lodderomyces
elongisporus) 		PF00018
(SH3_1) 		4 ILE A  42
SER A  21
LEU A  26
ASN A  25
 None
 1.07A 1y0xX-2kymA:
undetectable		 1y0xX-2kymA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		4 ILE B 191
SER B 172
LEU B 194
ASN B 219
 None
 1.17A 1y0xX-2p1nB:
undetectable		 1y0xX-2p1nB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 ILE A 161
SER A 119
ARG A 120
LEU A 123
 None
 1.17A 1y0xX-2qedA:
undetectable		 1y0xX-2qedA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkq PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-SD

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 ILE A 109
SER A  91
ARG A  90
LEU A 107
 None
 1.09A 1y0xX-2rkqA:
undetectable		 1y0xX-2rkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcz PROTEIN MEMO1

(Homo sapiens) 		PF01875
(Memo) 		4 ILE A 133
SER A 123
ARG A 121
LEU A 157
 None
 1.14A 1y0xX-3bczA:
undetectable		 1y0xX-3bczA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkn BACTERIOFERRITIN

(Mycolicibacterium
smegmatis) 		PF00210
(Ferritin) 		4 ILE A  62
ARG A  73
LEU A  15
ASN A  12
 None
 1.18A 1y0xX-3bknA:
undetectable		 1y0xX-3bknA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ILE B 179
SER B 170
LEU B 175
ASN C 117
 None
 1.05A 1y0xX-3bvhB:
undetectable		 1y0xX-3bvhB:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		4 ILE A 355
SER A 469
LEU A 359
ASN A 356
 None
 1.14A 1y0xX-3clwA:
undetectable		 1y0xX-3clwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 ILE A 474
SER A  17
LEU A 479
ASN A 478
 None
 1.10A 1y0xX-3cmmA:
undetectable		 1y0xX-3cmmA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		4 ILE A 533
SER A 364
LEU A 527
ASN A 530
 None
 1.13A 1y0xX-3cskA:
undetectable		 1y0xX-3cskA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		4 ILE B  35
SER B  95
LEU B  32
ASN B 103
 None
 1.11A 1y0xX-3draB:
undetectable		 1y0xX-3draB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9d ZGC:56074

(Danio rerio) 		PF00300
(His_Phos_1) 		4 ILE A 244
SER A 182
ARG A  10
ASN A 245
 None
None
PO4  A 267 ( 2.9A)
None
 0.97A 1y0xX-3e9dA:
undetectable		 1y0xX-3e9dA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 ILE A 209
SER A 201
ARG A 204
LEU A 206
 None
 1.09A 1y0xX-3egwA:
undetectable		 1y0xX-3egwA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE

(Legionella
pneumophila) 		PF13523
(Acetyltransf_8) 		4 ILE A  34
SER A  44
LEU A  38
ASN A  35
 None
 1.18A 1y0xX-3f5bA:
undetectable		 1y0xX-3f5bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkm OS03G0854200 PROTEIN

(Oryza sativa) 		PF01138
(RNase_PH) 		4 SER A 219
ARG A 221
LEU A 153
ASN A  12
 None
 1.06A 1y0xX-3hkmA:
undetectable		 1y0xX-3hkmA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hur ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 337
SER A 254
ARG A 333
LEU A 336
 None
 1.18A 1y0xX-3hurA:
undetectable		 1y0xX-3hurA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j26 CAPSID PROTEIN V20

(Mimivirus-dependent
virus Sputnik) 		no annotation 4 ILE A 472
SER A  58
LEU A 225
ASN A 115
 None
 0.94A 1y0xX-3j26A:
undetectable		 1y0xX-3j26A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k33 DEATH ON CURING
PROTEIN

(Escherichia
virus P1) 		PF02661
(Fic) 		4 SER A  79
ARG A  86
LEU A  84
ASN A  87
 None
 1.16A 1y0xX-3k33A:
undetectable		 1y0xX-3k33A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kar KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		4 ILE A 649
SER A 713
LEU A 653
ASN A 650
 None
 1.19A 1y0xX-3karA:
undetectable		 1y0xX-3karA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l1c KINESIN-14 NCD

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 ILE A 599
SER A 660
LEU A 603
ASN A 600
 None
 1.20A 1y0xX-3l1cA:
undetectable		 1y0xX-3l1cA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A

(Shewanella
denitrificans) 		PF00246
(Peptidase_M14) 		4 ILE A 275
ARG A 227
LEU A 316
ASN A 321
 None
UNL  A 378 ( 2.8A)
None
None
 1.17A 1y0xX-3l2nA:
undetectable		 1y0xX-3l2nA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE

(Saccharomyces
cerevisiae) 		PF00282
(Pyridoxal_deC) 		4 ILE C 488
SER C 539
LEU C 486
ASN C 487
 None
 1.20A 1y0xX-3mc6C:
undetectable		 1y0xX-3mc6C:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		4 ILE A 307
SER A 321
LEU A 311
ASN A 308
 None
 1.08A 1y0xX-3r5tA:
undetectable		 1y0xX-3r5tA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 ILE A 665
SER A 717
ARG A 659
LEU A 663
 None
 1.18A 1y0xX-3texA:
undetectable		 1y0xX-3texA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uau SURFACE-EXPOSED
LIPOPROTEIN

(Campylobacter
jejuni) 		PF16668
(JLPA) 		4 ILE A  94
SER A 128
ARG A  97
LEU A 130
 None
 1.20A 1y0xX-3uauA:
undetectable		 1y0xX-3uauA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ud2 ANKYRIN-1

(Homo sapiens) 		no annotation 4 ILE C 993
SER C 929
ARG C 927
LEU C 934
 None
 1.04A 1y0xX-3ud2C:
undetectable		 1y0xX-3ud2C:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2n 70 KDA PROTEIN

(Xanthomonas sp.
35Y) 		no annotation 4 ILE A 381
SER A 389
ARG A 370
ASN A 378
 None
 1.19A 1y0xX-4b2nA:
undetectable		 1y0xX-4b2nA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)

(Legionella
pneumophila) 		PF00351
(Biopterin_H) 		4 ILE A  61
SER A  68
ARG A  70
LEU A 124
 None
 1.07A 1y0xX-4bptA:
undetectable		 1y0xX-4bptA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		4 ILE A 576
SER A 567
ARG A 571
LEU A 573
 None
 1.13A 1y0xX-4bzkA:
undetectable		 1y0xX-4bzkA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccy CARBOXYLESTERASE
YBFK

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		4 ILE B 201
SER B 213
ARG B 212
LEU B  65
 None
 1.07A 1y0xX-4ccyB:
undetectable		 1y0xX-4ccyB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3n DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis) 		PF03989
(DNA_gyraseA_C) 		4 ILE A 767
SER A 675
LEU A 672
ASN A 715
 None
 1.01A 1y0xX-4g3nA:
undetectable		 1y0xX-4g3nA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkx BETA-GALACTOSIDE-SPE
CIFIC LECTIN 1 A
CHAIN

(Viscum album) 		PF00161
(RIP) 		4 ILE A  70
SER A  29
ARG A  41
LEU A  75
 None
None
DIO  A 307 (-4.4A)
None
 0.92A 1y0xX-4jkxA:
undetectable		 1y0xX-4jkxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 ILE A1061
SER A1023
ARG A1025
LEU A1030
 None
 1.14A 1y0xX-4kf7A:
undetectable		 1y0xX-4kf7A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Escherichia
coli) 		PF02733
(Dak1) 		4 ILE A 316
ARG A 313
LEU A 315
ASN A 314
 None
 1.20A 1y0xX-4lryA:
undetectable		 1y0xX-4lryA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxo FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		4 ILE A1354
ARG A1403
LEU A1400
ASN A1401
 None
 1.13A 1y0xX-4lxoA:
undetectable		 1y0xX-4lxoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 ILE A  14
SER A 105
LEU A 134
ASN A 133
 None
 1.17A 1y0xX-4my5A:
undetectable		 1y0xX-4my5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF13439
(Glyco_transf_4)
PF13692
(Glyco_trans_1_4) 		4 ILE A 225
SER A 262
ARG A 186
LEU A 192
 None
 1.17A 1y0xX-4n9wA:
undetectable		 1y0xX-4n9wA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 ILE A 408
SER A 189
LEU A 418
ASN A 417
 None
 1.16A 1y0xX-4pv4A:
undetectable		 1y0xX-4pv4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 299
ARG A 259
LEU A 288
ASN A 292
 None
 1.11A 1y0xX-4tz0A:
undetectable		 1y0xX-4tz0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u65 TWO COMPONENT
HISTIDINE KINASE,
GGDEF DOMAIN
PROTEIN/EAL DOMAIN
PROTEIN

(Legionella
pneumophila) 		PF16448
(LapD_MoxY_N) 		4 ILE A  58
SER A 120
LEU A  53
ASN A  59
 None
 1.19A 1y0xX-4u65A:
undetectable		 1y0xX-4u65A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa9 GALA PROTEIN TYPE 1,
3 OR 4

(Legionella
pneumophila) 		PF13516
(LRR_6) 		4 ILE A 235
SER A 201
LEU A 229
ASN A 232
 None
 1.02A 1y0xX-4xa9A:
undetectable		 1y0xX-4xa9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xze NUCLEOPROTEIN

(Hazara
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 ILE A 433
SER A 173
ARG A 178
LEU A 458
 None
 1.12A 1y0xX-4xzeA:
undetectable		 1y0xX-4xzeA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgs PUTATIVE D-LACTATE
DEHYDROGENASE

(Chlamydomonas
reinhardtii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A 272
SER A 244
ARG A 246
LEU A 271
 None
NAD  A1000 (-2.1A)
None
None
 1.18A 1y0xX-4zgsA:
undetectable		 1y0xX-4zgsA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		4 ILE A 260
ARG A 254
LEU A 256
ASN A 257
 None
 1.01A 1y0xX-5b1qA:
undetectable		 1y0xX-5b1qA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvl DESIGNED TIM BARREL
STIM11

(synthetic
construct) 		no annotation 4 ILE A  66
SER A  24
ARG A  23
LEU A  41
 None
 1.16A 1y0xX-5bvlA:
undetectable		 1y0xX-5bvlA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 ILE A  24
ARG A  54
LEU A  52
ASN A  55
 None
CD  A 505 (-2.7A)
None
None
 1.16A 1y0xX-5bzaA:
undetectable		 1y0xX-5bzaA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdh MAJOR ACID
PHOSPHATASE

(Legionella
pneumophila) 		PF00328
(His_Phos_2) 		4 ILE A  92
SER A  96
ARG A  95
LEU A 276
 None
 1.14A 1y0xX-5cdhA:
undetectable		 1y0xX-5cdhA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cws NUCLEOPORIN NSP1
NUCLEOPORIN NUP49

(Chaetomium
thermophilum) 		PF05064
(Nsp1_C)
no annotation 		4 ILE D 283
ARG C 497
LEU C 499
ASN C 502
 None
 1.15A 1y0xX-5cwsD:
undetectable		 1y0xX-5cwsD:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		4 ILE A  49
SER A  75
ARG A  42
LEU A  46
 None
 1.07A 1y0xX-5cykA:
undetectable		 1y0xX-5cykA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza C
virus) 		PF00603
(Flu_PA) 		4 ILE A 287
SER A 275
ARG A 279
LEU A 286
 None
 1.11A 1y0xX-5d9aA:
undetectable		 1y0xX-5d9aA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		4 ILE A 940
ARG A 979
LEU A 977
ASN A 980
 None
 1.18A 1y0xX-5dztA:
undetectable		 1y0xX-5dztA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		4 ILE A 523
SER A 641
LEU A 583
ASN A 584
 None
 1.15A 1y0xX-5frsA:
undetectable		 1y0xX-5frsA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h12 DEEP VENT DNA
POLYMERASE

(Pyrococcus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ILE A 568
SER A 412
LEU A 572
ASN A 569
 None
 1.19A 1y0xX-5h12A:
undetectable		 1y0xX-5h12A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h65 PROTECTION OF
TELOMERES PROTEIN 1

(Homo sapiens) 		no annotation 4 ILE A 474
SER A 507
ARG A 510
LEU A 485
 None
 1.18A 1y0xX-5h65A:
undetectable		 1y0xX-5h65A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il7 RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF12799
(LRR_4)
PF13516
(LRR_6) 		4 ILE A 207
ARG A 226
LEU A 224
ASN A 227
 None
 1.15A 1y0xX-5il7A:
undetectable		 1y0xX-5il7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it9 RIBOSOMAL PROTEIN
ES19

(Kluyveromyces
lactis) 		PF01090
(Ribosomal_S19e) 		4 ILE T 135
SER T 125
ARG T 130
LEU T 132
 None
None
G  21357 ( 4.6A)
None
 1.13A 1y0xX-5it9T:
undetectable		 1y0xX-5it9T:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 4 ILE A 124
ARG A 130
LEU A 122
ASN A 123
 None
 1.15A 1y0xX-5nofA:
undetectable		 1y0xX-5nofA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ods CLATHRIN HEAVY CHAIN
1

(Mus musculus) 		no annotation 4 ILE A   4
ARG A   8
LEU A   5
ASN A 333
 None
 1.00A 1y0xX-5odsA:
undetectable		 1y0xX-5odsA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 2
CONDENSIN COMPLEX
SUBUNIT 3

(Schizosaccharomyces
pombe) 		no annotation 4 ILE A 631
SER C 525
ARG C 527
LEU C 529
 None
 1.12A 1y0xX-5oqrA:
undetectable		 1y0xX-5oqrA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 ILE 4 415
SER 4 335
ARG 4 334
LEU 4 417
 None
 1.09A 1y0xX-5u8s4:
undetectable		 1y0xX-5u8s4:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		PF13281
(DUF4071) 		4 ILE A 315
ARG A 281
LEU A 319
ASN A 316
 None
 1.06A 1y0xX-5ulmA:
undetectable		 1y0xX-5ulmA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Lassa
mammarenavirus) 		PF00798
(Arena_glycoprot) 		4 ILE a 337
SER A 246
ARG A 248
ASN a 338
 None
 0.88A 1y0xX-5vk2a:
undetectable		 1y0xX-5vk2a:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 ILE A 597
SER A 577
ARG A 528
LEU A 596
 None
 1.16A 1y0xX-5vocA:
undetectable		 1y0xX-5vocA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vso YEAST DNAJ PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A  15
SER A  63
ARG A  68
LEU A  16
 None
 1.13A 1y0xX-5vsoA:
undetectable		 1y0xX-5vsoA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcx VL-SARAH(S37C)
CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		4 ILE B  29
SER B  52
ARG B  50
LEU B  33
 None
 0.98A 1y0xX-5xcxB:
undetectable		 1y0xX-5xcxB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF04212
(MIT) 		4 ILE A 252
SER A 284
ARG A 288
LEU A 256
 None
 1.09A 1y0xX-5xmiA:
undetectable		 1y0xX-5xmiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED

(Oryza sativa) 		no annotation 4 ILE A 237
SER A 334
ARG A 335
LEU A 257
 None
 1.16A 1y0xX-5xoiA:
undetectable		 1y0xX-5xoiA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 ILE B  72
SER B  93
ARG B 103
LEU B  77
 None
None
GOL  B 406 (-4.1A)
None
 1.17A 1y0xX-5y6qB:
undetectable		 1y0xX-5y6qB:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 4 ILE A  68
SER A 113
ARG A 100
LEU A 102
 None
 1.01A 1y0xX-5ybbA:
undetectable		 1y0xX-5ybbA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN

(Homo sapiens) 		no annotation 4 SER A  45
ARG A  44
LEU A 306
ASN A 307
 None
 1.17A 1y0xX-5yy8A:
undetectable		 1y0xX-5yy8A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11

(Homo sapiens) 		no annotation 4 ILE A  30
ARG A  51
LEU A  34
ASN A  33
 None
 1.02A 1y0xX-6ba5A:
undetectable		 1y0xX-6ba5A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11

(Homo sapiens) 		no annotation 4 ILE A  30
SER A  53
LEU A  34
ASN A  33
 None
 1.09A 1y0xX-6ba5A:
undetectable		 1y0xX-6ba5A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA

(Pyrococcus
furiosus) 		no annotation 4 ILE L 371
ARG L 342
LEU L 349
ASN L 348
 None
 0.94A 1y0xX-6cfwL:
undetectable		 1y0xX-6cfwL:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbh HOPQ

(Helicobacter
pylori) 		no annotation 4 ILE C  64
SER C 329
LEU C  67
ASN C  68
 None
 1.19A 1y0xX-6gbhC:
undetectable		 1y0xX-6gbhC:
15.91