SIMILAR PATTERNS OF AMINO ACIDS FOR 1Y0X_X_T44X500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia) 		PF00161
(RIP) 		5 ILE A  18
ILE A 127
MET A  50
PHE A  17
PHE A   4
 None
 1.39A 1y0xX-1ahaA:
0.0		 1y0xX-1ahaA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0n PROTEIN (SINI
PROTEIN)
PROTEIN (SINR
PROTEIN)

(Bacillus
subtilis) 		PF01381
(HTH_3)
PF08671
(SinI) 		5 ILE B  27
ALA B  25
MET B  19
PHE A  98
PHE A  95
 None
 1.36A 1y0xX-1b0nB:
undetectable		 1y0xX-1b0nB:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE A 402
ALA A 423
ILE A 278
MET A 391
PHE A 398
 None
 1.20A 1y0xX-1br2A:
undetectable		 1y0xX-1br2A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		5 ALA A 193
ARG A 181
LEU A 252
ILE A 255
PHE A  72
 None
 1.36A 1y0xX-1bt4A:
0.0		 1y0xX-1bt4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN

(Cricetulus
griseus) 		PF00004
(AAA) 		5 ILE A 702
ALA A 703
LEU A 718
ILE A 678
PHE A 694
 None
 1.20A 1y0xX-1d2nA:
0.1		 1y0xX-1d2nA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 ILE A 117
ALA A  25
HIS A  86
PHE A 123
PHE A 145
 None
 1.41A 1y0xX-1efpA:
0.0		 1y0xX-1efpA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR

(Homo sapiens) 		PF13374
(TPR_10)
PF13432
(TPR_16) 		5 ALA A 343
ARG A 520
LEU A 359
ILE A 388
MET A 332
 None
 1.45A 1y0xX-1fchA:
undetectable		 1y0xX-1fchA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 MET A 208
ARG A 216
ILE A 196
PHE A 155
PHE A 120
 None
 0.99A 1y0xX-1gqrA:
0.0		 1y0xX-1gqrA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hu3 EIF4GII

(Homo sapiens) 		PF02854
(MIF4G) 		5 ILE A 792
ARG A 888
LEU A 899
ILE A 896
PHE A 833
 None
 1.40A 1y0xX-1hu3A:
0.0		 1y0xX-1hu3A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		5 ILE A 258
ARG A 470
LEU A  77
ILE A  80
PHE A 262
 None
 1.28A 1y0xX-1i5pA:
0.9		 1y0xX-1i5pA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		5 ILE A 167
ALA A 170
LEU A  56
ILE A  66
PHE A   5
 None
 1.25A 1y0xX-1ikpA:
undetectable		 1y0xX-1ikpA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB

(Thermotoga
maritima) 		PF06723
(MreB_Mbl) 		5 ALA A 319
ARG A  97
LEU A  80
ILE A  84
MET A  65
 None
 1.16A 1y0xX-1jcfA:
undetectable		 1y0xX-1jcfA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 222
ALA A 225
ARG A 228
MET A 256
MET A 259
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
PHE A 405
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
None
 0.71A 1y0xX-1navA:
37.3		 1y0xX-1navA:
83.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ILE A 222
ALA A 225
ARG A 266
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
PHE A 405
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
None
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
None
 0.79A 1y0xX-1navA:
37.3		 1y0xX-1navA:
83.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ILE A 222
ALA A 225
MET A 259
LEU A 292
ILE A 377
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.27A 1y0xX-1navA:
37.3		 1y0xX-1navA:
83.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus) 		PF06407
(BDV_P40) 		5 ALA X 193
LEU X  82
ILE X 136
PHE X 206
PHE X  90
 None
 1.40A 1y0xX-1pp1X:
undetectable		 1y0xX-1pp1X:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 276
ALA A 279
ARG A 282
MET A 310
MET A 313
ARG A 320
LEU A 346
ILE A 353
HIS A 435
PHE A 455
PHE A 459
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.6A)
G24  A 462 (-4.2A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
None
 0.57A 1y0xX-1q4xA:
37.5		 1y0xX-1q4xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 276
ALA A 279
ARG A 282
MET A 313
LEU A 341
ILE A 353
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.6A)
None
None
 1.37A 1y0xX-1q4xA:
37.5		 1y0xX-1q4xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 ILE A 424
ALA A 106
MET A 452
PHE A 425
PHE A 503
 None
HEA  A 601 (-3.3A)
HEA  A 601 (-4.1A)
None
None
 1.20A 1y0xX-1qleA:
undetectable		 1y0xX-1qleA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		5 ILE A  95
MET A  67
LEU A  78
PHE A 135
PHE A 144
 None
 1.31A 1y0xX-1ru4A:
undetectable		 1y0xX-1ru4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snz ALDOSE 1-EPIMERASE

(Homo sapiens) 		PF01263
(Aldose_epim) 		5 ILE A 196
ALA A 258
LEU A 230
ILE A 189
PHE A 246
 None
 1.45A 1y0xX-1snzA:
undetectable		 1y0xX-1snzA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Arabidopsis
thaliana) 		PF00903
(Glyoxalase) 		5 ILE A  29
ARG A 377
LEU A  47
ILE A 374
PHE A  31
 None
 1.45A 1y0xX-1tg5A:
undetectable		 1y0xX-1tg5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE ALPHA
SUBUNIT
2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 197
ARG A 255
LEU A 162
MET B  54
PHE A 189
 None
 1.42A 1y0xX-1umbA:
undetectable		 1y0xX-1umbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w SISTER CHROMATID
COHESION PROTEIN 1
STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N)
PF04824
(Rad21_Rec8) 		5 ILE A1175
ALA A1172
MET A1194
ARG E 522
ILE A  32
 None
 1.20A 1y0xX-1w1wA:
undetectable		 1y0xX-1w1wA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ILE A 158
ALA A 155
ARG A  92
LEU A  42
ILE A 112
 None
PD8  A1421 (-3.9A)
PD8  A1421 ( 4.9A)
None
None
 1.29A 1y0xX-1w78A:
undetectable		 1y0xX-1w78A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 ILE A 610
ALA A 611
ARG A 520
LEU A 602
PHE A 594
 None
 1.43A 1y0xX-1w99A:
undetectable		 1y0xX-1w99A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woy METHIONYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF09334
(tRNA-synt_1g) 		5 ILE A 418
MET A 363
ARG A 435
LEU A 467
ILE A 489
 None
 1.34A 1y0xX-1woyA:
undetectable		 1y0xX-1woyA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpo RHO TRANSCRIPTION
TERMINATION FACTOR

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		5 ALA A 159
ARG A 144
LEU A 263
ILE A 261
MET A 219
 None
 1.41A 1y0xX-1xpoA:
undetectable		 1y0xX-1xpoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		5 ALA A 485
ARG A 488
ILE A  81
PHE A 211
PHE A 421
 None
 1.34A 1y0xX-1y3nA:
undetectable		 1y0xX-1y3nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z14 VP2

(Rodent
protoparvovirus
1) 		PF00740
(Parvo_coat) 		5 ILE A 468
MET A 533
ARG A 580
LEU A 123
ILE A 131
 None
 1.01A 1y0xX-1z14A:
undetectable		 1y0xX-1z14A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae8 IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Staphylococcus
aureus) 		PF00475
(IGPD) 		5 ILE A  72
LEU A 176
ILE A  80
PHE A  41
PHE A 168
 None
 1.43A 1y0xX-2ae8A:
undetectable		 1y0xX-2ae8A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvt BETA-1,4-MANNANASE

(Cellulomonas
fimi) 		PF02156
(Glyco_hydro_26) 		5 MET A 319
ARG A 315
LEU A 304
ILE A 307
PHE A 354
 None
 1.04A 1y0xX-2bvtA:
undetectable		 1y0xX-2bvtA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccq PEPTIDE N-GLYCANASE
HOMOLOG

(Homo sapiens) 		PF09409
(PUB) 		5 ILE A  42
ARG A  44
ILE A 105
PHE A  89
PHE A  80
 None
 1.45A 1y0xX-2ccqA:
undetectable		 1y0xX-2ccqA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		5 ILE A  77
ALA A 254
ARG A 255
ARG A   8
ILE A  32
 None
 1.41A 1y0xX-2d3iA:
undetectable		 1y0xX-2d3iA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d57 AQUAPORIN-4

(Rattus
norvegicus) 		PF00230
(MIP) 		5 ILE A  81
ALA A  82
ILE A 199
HIS A 201
PHE A  48
 None
 1.08A 1y0xX-2d57A:
undetectable		 1y0xX-2d57A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 ALA A 188
LEU A  92
HIS A 159
PHE A  55
PHE A  96
 None
 1.31A 1y0xX-2olsA:
undetectable		 1y0xX-2olsA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 ALA A 191
MET A 320
LEU A 329
ILE A 327
PHE A 338
 None
 1.40A 1y0xX-2v26A:
undetectable		 1y0xX-2v26A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 ILE A 333
ALA A 365
MET A 307
ILE A 603
MET A 394
 None
 1.32A 1y0xX-2vcaA:
undetectable		 1y0xX-2vcaA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		5 ILE A 225
ALA A 228
MET A 249
LEU A  17
ILE A 191
 None
None
None
None
WSA  A1350 (-3.7A)
 1.35A 1y0xX-2yy5A:
undetectable		 1y0xX-2yy5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cu3 DOMAIN OF UNKNOWN
FUNCTION WITH A
CYSTATIN-LIKE FOLD

(Nostoc
punctiforme) 		PF14534
(DUF4440) 		5 ILE A  98
MET A  24
ARG A  18
LEU A 132
ILE A 129
 None
 1.36A 1y0xX-3cu3A:
undetectable		 1y0xX-3cu3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5n Q97W15_SULSO

(Sulfolobus
solfataricus) 		PF12804
(NTP_transf_3) 		5 ILE A 133
ALA A 150
ARG A  15
ILE A  46
PHE A 138
 None
 1.40A 1y0xX-3d5nA:
undetectable		 1y0xX-3d5nA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		5 ILE A 212
ALA A 209
ARG A 210
MET A 224
LEU A 244
 None
 1.40A 1y0xX-3f8tA:
undetectable		 1y0xX-3f8tA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		5 ALA A 108
ARG A 111
LEU A  18
ILE A  28
PHE A  53
 None
 1.40A 1y0xX-3fdgA:
undetectable		 1y0xX-3fdgA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 ILE A 118
MET A 199
ARG A 159
LEU A 205
PHE A 189
 None
None
NA  A 391 (-3.1A)
None
None
 1.25A 1y0xX-3h2zA:
undetectable		 1y0xX-3h2zA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 ILE A 183
ALA A 142
MET A 172
LEU A  18
ILE A 208
 None
 1.43A 1y0xX-3h55A:
undetectable		 1y0xX-3h55A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		5 ILE A 106
ALA A 107
ARG A 115
ILE A  63
PHE A 268
 None
 1.37A 1y0xX-3h9pA:
undetectable		 1y0xX-3h9pA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR

(Staphylococcus
aureus) 		PF13377
(Peripla_BP_3) 		5 ILE A 249
ALA A 247
ARG A 339
LEU A 331
ILE A 333
 None
 1.18A 1y0xX-3hcwA:
undetectable		 1y0xX-3hcwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Nitrosospira
multiformis) 		PF00365
(PFK) 		5 ILE A 215
LEU A 383
ILE A 387
MET A 363
PHE A 217
 None
 1.31A 1y0xX-3hnoA:
undetectable		 1y0xX-3hnoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuv UNCHARACTERIZED TETR
FAMILY PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 ILE A  13
ALA A  16
ARG A  19
LEU A  42
HIS A  31
 None
 1.24A 1y0xX-3iuvA:
undetectable		 1y0xX-3iuvA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Marinobacter
hydrocarbonoclasticus) 		PF00365
(PFK) 		5 ILE A 215
LEU A 383
ILE A 387
MET A 363
PHE A 217
 None
 1.42A 1y0xX-3k2qA:
undetectable		 1y0xX-3k2qA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B 619
ALA B 616
LEU B 530
ILE B 542
PHE B 178
 None
 1.40A 1y0xX-3kx2B:
undetectable		 1y0xX-3kx2B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7o LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2) 		5 ALA A  32
LEU A  83
ILE A  85
PHE A  70
PHE A  51
 None
None
L9R  A 301 (-4.6A)
L9R  A 301 ( 4.3A)
None
 1.37A 1y0xX-3m7oA:
undetectable		 1y0xX-3m7oA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		5 ILE A 235
ALA A 286
ILE A  85
HIS A  92
PHE A 236
 None
HC9  A 501 ( 4.1A)
None
None
None
 1.38A 1y0xX-3mzsA:
1.9		 1y0xX-3mzsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 273
ALA A 325
ILE A 123
HIS A 130
PHE A 274
 None
2DC  A 602 ( 3.8A)
None
None
None
 1.35A 1y0xX-3na0A:
2.1		 1y0xX-3na0A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o80 HEXOKINASE

(Kluyveromyces
lactis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ILE A 349
MET A 313
ARG A 390
LEU A 379
PHE A 364
 None
 1.41A 1y0xX-3o80A:
undetectable		 1y0xX-3o80A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		5 ILE A 432
ALA A 114
MET A 460
PHE A 433
PHE A 511
 HEA  A   1 ( 4.6A)
HEA  A   1 ( 4.0A)
HEA  A   1 (-4.0A)
None
HEA  A   1 ( 4.9A)
 1.15A 1y0xX-3omnA:
undetectable		 1y0xX-3omnA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfn NAD KINASE

(Homo sapiens) 		PF01513
(NAD_kinase) 		5 ALA A 232
ARG A  97
MET A 202
MET A 134
PHE A 177
 None
 1.45A 1y0xX-3pfnA:
undetectable		 1y0xX-3pfnA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qg5 RAD50

(Thermotoga
maritima) 		PF13476
(AAA_23)
PF13558
(SbcCD_C) 		5 ILE A 777
ALA A 773
ARG A 741
LEU A 821
PHE A 827
 None
 1.32A 1y0xX-3qg5A:
undetectable		 1y0xX-3qg5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2) 		5 ALA C  32
LEU C  83
ILE C  85
PHE C  70
PHE C  51
 None
 1.40A 1y0xX-3t6qC:
undetectable		 1y0xX-3t6qC:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00180
(Iso_dh) 		5 ILE A   7
ALA A  73
LEU A  32
ILE A 325
PHE A  42
 None
 1.38A 1y0xX-3ty4A:
undetectable		 1y0xX-3ty4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn4 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 13

(Homo sapiens) 		PF00090
(TSP_1) 		5 ILE A 673
ALA A 586
ARG A 639
ILE A 611
PHE A 573
 None
 1.45A 1y0xX-3vn4A:
undetectable		 1y0xX-3vn4A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnp HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00132
(Hexapep) 		5 ILE A 114
ALA A 112
ARG A 155
LEU A  85
ILE A  73
 None
 1.18A 1y0xX-3vnpA:
undetectable		 1y0xX-3vnpA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ARG A 453
LEU A 344
ILE A 121
PHE A 163
PHE A 170
 None
 1.40A 1y0xX-4aj9A:
undetectable		 1y0xX-4aj9A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 ILE A 417
ALA A 400
ARG A 403
LEU A 430
PHE A 467
 None
 1.44A 1y0xX-4c2tA:
undetectable		 1y0xX-4c2tA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		5 ILE A 185
MET A 164
LEU A  72
ILE A  76
PHE A  34
 None
 1.37A 1y0xX-4c90A:
undetectable		 1y0xX-4c90A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ILE A 110
ALA A 783
ARG A1019
ILE A1005
PHE A 119
 None
 1.31A 1y0xX-4f4cA:
undetectable		 1y0xX-4f4cA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE

(Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		5 MET A 375
LEU A 224
ILE A 410
PHE A 205
PHE A 197
 None
 1.36A 1y0xX-4hw8A:
undetectable		 1y0xX-4hw8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 1.10A 1y0xX-4m38A:
undetectable		 1y0xX-4m38A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb5 CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18)
PF16403
(DUF5011) 		5 ILE A 101
ARG A 109
LEU A  86
ILE A  90
PHE A 145
 None
 1.27A 1y0xX-4mb5A:
undetectable		 1y0xX-4mb5A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntl LIPOPROTEIN, YAEC
FAMILY

(Enterococcus
faecalis) 		PF03180
(Lipoprotein_9) 		5 ILE A 177
ALA A 131
MET A 198
ILE A 217
PHE A 179
 None
 1.31A 1y0xX-4ntlA:
undetectable		 1y0xX-4ntlA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oje EFF-1A

(Caenorhabditis
elegans) 		PF14884
(EFF-AFF) 		5 ALA H  73
LEU H 246
ILE H 233
PHE H 403
PHE H  66
 None
 1.16A 1y0xX-4ojeH:
undetectable		 1y0xX-4ojeH:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo2 CHLOROPHENOL-4-MONOO
XYGENASE

(Streptomyces
globisporus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		5 ILE A 106
ALA A 107
ARG A 111
ARG A 350
PHE A  89
 None
 1.31A 1y0xX-4oo2A:
undetectable		 1y0xX-4oo2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rot ESTERASE A

(Streptococcus
pyogenes) 		PF00756
(Esterase) 		5 ILE A   6
ALA A   5
LEU A  99
PHE A 106
PHE A 107
 None
 1.37A 1y0xX-4rotA:
undetectable		 1y0xX-4rotA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0p LIPOYL SYNTHASE 2

(Thermosynechococcus
elongatus) 		PF04055
(Radical_SAM) 		5 ILE B 158
ALA B 161
MET B 123
LEU B  58
ILE B  89
 None
 1.28A 1y0xX-4u0pB:
undetectable		 1y0xX-4u0pB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18) 		5 ILE A 101
ARG A 109
LEU A  86
ILE A  90
PHE A 145
 None
None
None
ACT  A 410 (-4.8A)
None
 1.27A 1y0xX-4w5zA:
undetectable		 1y0xX-4w5zA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus sp.
JAMB750) 		PF02156
(Glyco_hydro_26) 		5 MET A 360
ARG A 356
LEU A 345
ILE A 348
PHE A 404
 None
 1.19A 1y0xX-4yn5A:
undetectable		 1y0xX-4yn5A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z45 ODORANT-BINDING
PROTEIN NRIBOBP3

(Nasonovia
ribisnigri) 		PF01395
(PBP_GOBP) 		5 ILE A  46
MET A   3
MET A 108
LEU A  67
ILE A  82
 None
 1.28A 1y0xX-4z45A:
undetectable		 1y0xX-4z45A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		5 ILE A 391
ALA A 387
LEU A 433
ILE A 408
PHE A 395
 None
 1.29A 1y0xX-5b3hA:
undetectable		 1y0xX-5b3hA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		5 ILE A  14
ALA A  17
LEU A 229
ILE A 225
PHE A 154
 None
 1.26A 1y0xX-5c65A:
undetectable		 1y0xX-5c65A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ILE A  93
ARG A 113
LEU A  77
ILE A  23
PHE A  88
 None
 1.15A 1y0xX-5ce6A:
undetectable		 1y0xX-5ce6A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		5 ILE A  92
ALA A  91
LEU A  33
ILE A  35
PHE A  82
 None
 1.31A 1y0xX-5d6aA:
undetectable		 1y0xX-5d6aA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 ILE A 481
ARG A 689
LEU A 601
PHE A 453
PHE A 544
 None
 1.25A 1y0xX-5dkxA:
undetectable		 1y0xX-5dkxA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		5 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.96A 1y0xX-5egeA:
undetectable		 1y0xX-5egeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 0.99A 1y0xX-5ekuA:
undetectable		 1y0xX-5ekuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Haemophilus
influenzae) 		PF00005
(ABC_tran) 		5 ILE A 553
ALA A 550
LEU A 571
HIS A 581
PHE A 585
 None
 1.45A 1y0xX-5eumA:
undetectable		 1y0xX-5eumA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 ILE A 337
ALA A 340
MET A 261
PHE A 244
PHE A 319
 None
 1.36A 1y0xX-5fxeA:
undetectable		 1y0xX-5fxeA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		5 ARG A 431
LEU A 466
ILE A 469
PHE A 333
PHE A 326
 None
 1.44A 1y0xX-5icqA:
undetectable		 1y0xX-5icqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idv LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Acinetobacter
baumannii) 		PF00005
(ABC_tran) 		5 ILE A 244
ALA A 241
LEU A 262
HIS A 272
PHE A 276
 None
 1.45A 1y0xX-5idvA:
undetectable		 1y0xX-5idvA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvf SITE-DETERMINING
PROTEIN

(Pseudomonas
aeruginosa) 		PF10609
(ParA) 		5 ILE A 117
ARG A 260
ARG A  40
ILE A  13
PHE A 114
 None
 1.42A 1y0xX-5jvfA:
undetectable		 1y0xX-5jvfA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mh5 D-2-HYDROXYACID
DEHYDROGENASE

(Haloferax
mediterranei) 		no annotation 5 ILE A 244
ALA A 245
ARG A 109
LEU A 249
PHE A 212
 None
 1.39A 1y0xX-5mh5A:
undetectable		 1y0xX-5mh5A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpt CITRININ POLYKETIDE
SYNTHASE

(Monascus
purpureus) 		PF08242
(Methyltransf_12) 		5 ILE A1931
ALA A1928
LEU A1874
ILE A1845
PHE A2103
 None
 1.40A 1y0xX-5mptA:
undetectable		 1y0xX-5mptA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpu PUTATIVE
UNCHARACTERIZED
PROTEIN

(Campylobacter
jejuni) 		PF05523
(FdtA) 		5 ILE A  39
MET A  99
LEU A  60
ILE A  91
PHE A 102
 None
 1.29A 1y0xX-5tpuA:
undetectable		 1y0xX-5tpuA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 ALA A  82
ARG A  21
ILE A  39
PHE A 146
PHE A 634
 None
 1.26A 1y0xX-5tusA:
undetectable		 1y0xX-5tusA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 ILE A 112
ALA A 222
LEU A  17
ILE A  20
PHE A   6
 None
 1.28A 1y0xX-5ujuA:
undetectable		 1y0xX-5ujuA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 ILE A 170
ALA A 137
LEU A 233
ILE A 235
PHE A 174
 None
 1.23A 1y0xX-5vemA:
undetectable		 1y0xX-5vemA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 5 ILE A 298
ALA A 367
ARG A 411
LEU A 327
ILE A 403
 None
EDO  A 604 (-3.7A)
None
None
None
 1.41A 1y0xX-5wi9A:
undetectable		 1y0xX-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE G 215
ALA G 218
LEU G 359
ILE G 520
PHE G 298
 None
 1.35A 1y0xX-5x6oG:
undetectable		 1y0xX-5x6oG:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE B1212
ALA B1213
ARG B1215
HIS A  92
PHE A  95
 None
 1.32A 1y0xX-5xogB:
undetectable		 1y0xX-5xogB:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum) 		no annotation 5 ILE A  43
MET A  36
ARG A  91
LEU A  54
ILE A 115
 None
 1.43A 1y0xX-5z7rA:
undetectable		 1y0xX-5z7rA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B 200
ALA B 204
ARG B  18
PHE B 195
PHE B 192
 None
 1.33A 1y0xX-6c6lB:
undetectable		 1y0xX-6c6lB:
14.95