SIMILAR PATTERNS OF AMINO ACIDS FOR 1Y0X_X_T44X500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia) 		PF00161
(RIP) 		5 ILE A  18
ILE A 127
MET A  50
PHE A  17
PHE A   4
 None
 1.39A 1y0xX-1ahaA:
0.0		 1y0xX-1ahaA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0n PROTEIN (SINI
PROTEIN)
PROTEIN (SINR
PROTEIN)

(Bacillus
subtilis) 		PF01381
(HTH_3)
PF08671
(SinI) 		5 ILE B  27
ALA B  25
MET B  19
PHE A  98
PHE A  95
 None
 1.36A 1y0xX-1b0nB:
undetectable		 1y0xX-1b0nB:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE A 402
ALA A 423
ILE A 278
MET A 391
PHE A 398
 None
 1.20A 1y0xX-1br2A:
undetectable		 1y0xX-1br2A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		5 ALA A 193
ARG A 181
LEU A 252
ILE A 255
PHE A  72
 None
 1.36A 1y0xX-1bt4A:
0.0		 1y0xX-1bt4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN

(Cricetulus
griseus) 		PF00004
(AAA) 		5 ILE A 702
ALA A 703
LEU A 718
ILE A 678
PHE A 694
 None
 1.20A 1y0xX-1d2nA:
0.1		 1y0xX-1d2nA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 ILE A 117
ALA A  25
HIS A  86
PHE A 123
PHE A 145
 None
 1.41A 1y0xX-1efpA:
0.0		 1y0xX-1efpA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR

(Homo sapiens) 		PF13374
(TPR_10)
PF13432
(TPR_16) 		5 ALA A 343
ARG A 520
LEU A 359
ILE A 388
MET A 332
 None
 1.45A 1y0xX-1fchA:
undetectable		 1y0xX-1fchA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 MET A 208
ARG A 216
ILE A 196
PHE A 155
PHE A 120
 None
 0.99A 1y0xX-1gqrA:
0.0		 1y0xX-1gqrA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hu3 EIF4GII

(Homo sapiens) 		PF02854
(MIF4G) 		5 ILE A 792
ARG A 888
LEU A 899
ILE A 896
PHE A 833
 None
 1.40A 1y0xX-1hu3A:
0.0		 1y0xX-1hu3A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		5 ILE A 258
ARG A 470
LEU A  77
ILE A  80
PHE A 262
 None
 1.28A 1y0xX-1i5pA:
0.9		 1y0xX-1i5pA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		5 ILE A 167
ALA A 170
LEU A  56
ILE A  66
PHE A   5
 None
 1.25A 1y0xX-1ikpA:
undetectable		 1y0xX-1ikpA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB

(Thermotoga
maritima) 		PF06723
(MreB_Mbl) 		5 ALA A 319
ARG A  97
LEU A  80
ILE A  84
MET A  65
 None
 1.16A 1y0xX-1jcfA:
undetectable		 1y0xX-1jcfA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 222
ALA A 225
ARG A 228
MET A 256
MET A 259
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
PHE A 405
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
None
 0.71A 1y0xX-1navA:
37.3		 1y0xX-1navA:
83.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ILE A 222
ALA A 225
ARG A 266
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
PHE A 405
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
None
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
None
 0.79A 1y0xX-1navA:
37.3		 1y0xX-1navA:
83.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ILE A 222
ALA A 225
MET A 259
LEU A 292
ILE A 377
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.27A 1y0xX-1navA:
37.3		 1y0xX-1navA:
83.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus) 		PF06407
(BDV_P40) 		5 ALA X 193
LEU X  82
ILE X 136
PHE X 206
PHE X  90
 None
 1.40A 1y0xX-1pp1X:
undetectable		 1y0xX-1pp1X:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 276
ALA A 279
ARG A 282
MET A 310
MET A 313
ARG A 320
LEU A 346
ILE A 353
HIS A 435
PHE A 455
PHE A 459
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.6A)
G24  A 462 (-4.2A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
None
 0.57A 1y0xX-1q4xA:
37.5		 1y0xX-1q4xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 276
ALA A 279
ARG A 282
MET A 313
LEU A 341
ILE A 353
 G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.6A)
None
None
 1.37A 1y0xX-1q4xA:
37.5		 1y0xX-1q4xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 ILE A 424
ALA A 106
MET A 452
PHE A 425
PHE A 503
 None
HEA  A 601 (-3.3A)
HEA  A 601 (-4.1A)
None
None
 1.20A 1y0xX-1qleA:
undetectable		 1y0xX-1qleA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		5 ILE A  95
MET A  67
LEU A  78
PHE A 135
PHE A 144
 None
 1.31A 1y0xX-1ru4A:
undetectable		 1y0xX-1ru4A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snz ALDOSE 1-EPIMERASE

(Homo sapiens) 		PF01263
(Aldose_epim) 		5 ILE A 196
ALA A 258
LEU A 230
ILE A 189
PHE A 246
 None
 1.45A 1y0xX-1snzA:
undetectable		 1y0xX-1snzA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tg5 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Arabidopsis
thaliana) 		PF00903
(Glyoxalase) 		5 ILE A  29
ARG A 377
LEU A  47
ILE A 374
PHE A  31
 None
 1.45A 1y0xX-1tg5A:
undetectable		 1y0xX-1tg5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE ALPHA
SUBUNIT
2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 197
ARG A 255
LEU A 162
MET B  54
PHE A 189
 None
 1.42A 1y0xX-1umbA:
undetectable		 1y0xX-1umbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w SISTER CHROMATID
COHESION PROTEIN 1
STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N)
PF04824
(Rad21_Rec8) 		5 ILE A1175
ALA A1172
MET A1194
ARG E 522
ILE A  32
 None
 1.20A 1y0xX-1w1wA:
undetectable		 1y0xX-1w1wA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ILE A 158
ALA A 155
ARG A  92
LEU A  42
ILE A 112
 None
PD8  A1421 (-3.9A)
PD8  A1421 ( 4.9A)
None
None
 1.29A 1y0xX-1w78A:
undetectable		 1y0xX-1w78A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 ILE A 610
ALA A 611
ARG A 520
LEU A 602
PHE A 594
 None
 1.43A 1y0xX-1w99A:
undetectable		 1y0xX-1w99A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woy METHIONYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF09334
(tRNA-synt_1g) 		5 ILE A 418
MET A 363
ARG A 435
LEU A 467
ILE A 489
 None
 1.34A 1y0xX-1woyA:
undetectable		 1y0xX-1woyA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpo RHO TRANSCRIPTION
TERMINATION FACTOR

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		5 ALA A 159
ARG A 144
LEU A 263
ILE A 261
MET A 219
 None
 1.41A 1y0xX-1xpoA:
undetectable		 1y0xX-1xpoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		5 ALA A 485
ARG A 488
ILE A  81
PHE A 211
PHE A 421
 None
 1.34A 1y0xX-1y3nA:
undetectable		 1y0xX-1y3nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z14 VP2

(Rodent
protoparvovirus
1) 		PF00740
(Parvo_coat) 		5 ILE A 468
MET A 533
ARG A 580
LEU A 123
ILE A 131
 None
 1.01A 1y0xX-1z14A:
undetectable		 1y0xX-1z14A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae8 IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Staphylococcus
aureus) 		PF00475
(IGPD) 		5 ILE A  72
LEU A 176
ILE A  80
PHE A  41
PHE A 168
 None
 1.43A 1y0xX-2ae8A:
undetectable		 1y0xX-2ae8A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvt BETA-1,4-MANNANASE

(Cellulomonas
fimi) 		PF02156
(Glyco_hydro_26) 		5 MET A 319
ARG A 315
LEU A 304
ILE A 307
PHE A 354
 None
 1.04A 1y0xX-2bvtA:
undetectable		 1y0xX-2bvtA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccq PEPTIDE N-GLYCANASE
HOMOLOG

(Homo sapiens) 		PF09409
(PUB) 		5 ILE A  42
ARG A  44
ILE A 105
PHE A  89
PHE A  80
 None
 1.45A 1y0xX-2ccqA:
undetectable		 1y0xX-2ccqA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		5 ILE A  77
ALA A 254
ARG A 255
ARG A   8
ILE A  32
 None
 1.41A 1y0xX-2d3iA:
undetectable		 1y0xX-2d3iA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d57 AQUAPORIN-4

(Rattus
norvegicus) 		PF00230
(MIP) 		5 ILE A  81
ALA A  82
ILE A 199
HIS A 201
PHE A  48
 None
 1.08A 1y0xX-2d57A:
undetectable		 1y0xX-2d57A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 ALA A 188
LEU A  92
HIS A 159
PHE A  55
PHE A  96
 None
 1.31A 1y0xX-2olsA:
undetectable		 1y0xX-2olsA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		5 ALA A 191
MET A 320
LEU A 329
ILE A 327
PHE A 338
 None
 1.40A 1y0xX-2v26A:
undetectable		 1y0xX-2v26A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 ILE A 333
ALA A 365
MET A 307
ILE A 603
MET A 394
 None
 1.32A 1y0xX-2vcaA:
undetectable		 1y0xX-2vcaA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		5 ILE A 225
ALA A 228
MET A 249
LEU A  17
ILE A 191
 None
None
None
None
WSA  A1350 (-3.7A)
 1.35A 1y0xX-2yy5A:
undetectable		 1y0xX-2yy5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cu3 DOMAIN OF UNKNOWN
FUNCTION WITH A
CYSTATIN-LIKE FOLD

(Nostoc
punctiforme) 		PF14534
(DUF4440) 		5 ILE A  98
MET A  24
ARG A  18
LEU A 132
ILE A 129
 None
 1.36A 1y0xX-3cu3A:
undetectable		 1y0xX-3cu3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5n Q97W15_SULSO

(Sulfolobus
solfataricus) 		PF12804
(NTP_transf_3) 		5 ILE A 133
ALA A 150
ARG A  15
ILE A  46
PHE A 138
 None
 1.40A 1y0xX-3d5nA:
undetectable		 1y0xX-3d5nA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		5 ILE A 212
ALA A 209
ARG A 210
MET A 224
LEU A 244
 None
 1.40A 1y0xX-3f8tA:
undetectable		 1y0xX-3f8tA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		5 ALA A 108
ARG A 111
LEU A  18
ILE A  28
PHE A  53
 None
 1.40A 1y0xX-3fdgA:
undetectable		 1y0xX-3fdgA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 ILE A 118
MET A 199
ARG A 159
LEU A 205
PHE A 189
 None
None
NA  A 391 (-3.1A)
None
None
 1.25A 1y0xX-3h2zA:
undetectable		 1y0xX-3h2zA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 ILE A 183
ALA A 142
MET A 172
LEU A  18
ILE A 208
 None
 1.43A 1y0xX-3h55A:
undetectable		 1y0xX-3h55A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		5 ILE A 106
ALA A 107
ARG A 115
ILE A  63
PHE A 268
 None
 1.37A 1y0xX-3h9pA:
undetectable		 1y0xX-3h9pA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR

(Staphylococcus
aureus) 		PF13377
(Peripla_BP_3) 		5 ILE A 249
ALA A 247
ARG A 339
LEU A 331
ILE A 333
 None
 1.18A 1y0xX-3hcwA:
undetectable		 1y0xX-3hcwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hno PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Nitrosospira
multiformis) 		PF00365
(PFK) 		5 ILE A 215
LEU A 383
ILE A 387
MET A 363
PHE A 217
 None
 1.31A 1y0xX-3hnoA:
undetectable		 1y0xX-3hnoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuv UNCHARACTERIZED TETR
FAMILY PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 ILE A  13
ALA A  16
ARG A  19
LEU A  42
HIS A  31
 None
 1.24A 1y0xX-3iuvA:
undetectable		 1y0xX-3iuvA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Marinobacter
hydrocarbonoclasticus) 		PF00365
(PFK) 		5 ILE A 215
LEU A 383
ILE A 387
MET A 363
PHE A 217
 None
 1.42A 1y0xX-3k2qA:
undetectable		 1y0xX-3k2qA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B 619
ALA B 616
LEU B 530
ILE B 542
PHE B 178
 None
 1.40A 1y0xX-3kx2B:
undetectable		 1y0xX-3kx2B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7o LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2) 		5 ALA A  32
LEU A  83
ILE A  85
PHE A  70
PHE A  51
 None
None
L9R  A 301 (-4.6A)
L9R  A 301 ( 4.3A)
None
 1.37A 1y0xX-3m7oA:
undetectable		 1y0xX-3m7oA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		5 ILE A 235
ALA A 286
ILE A  85
HIS A  92
PHE A 236
 None
HC9  A 501 ( 4.1A)
None
None
None
 1.38A 1y0xX-3mzsA:
1.9		 1y0xX-3mzsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 273
ALA A 325
ILE A 123
HIS A 130
PHE A 274
 None
2DC  A 602 ( 3.8A)
None
None
None
 1.35A 1y0xX-3na0A:
2.1		 1y0xX-3na0A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o80 HEXOKINASE

(Kluyveromyces
lactis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 ILE A 349
MET A 313
ARG A 390
LEU A 379
PHE A 364
 None
 1.41A 1y0xX-3o80A:
undetectable		 1y0xX-3o80A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		5 ILE A 432
ALA A 114
MET A 460
PHE A 433
PHE A 511
 HEA  A   1 ( 4.6A)
HEA  A   1 ( 4.0A)
HEA  A   1 (-4.0A)
None
HEA  A   1 ( 4.9A)
 1.15A 1y0xX-3omnA:
undetectable		 1y0xX-3omnA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfn NAD KINASE

(Homo sapiens) 		PF01513
(NAD_kinase) 		5 ALA A 232
ARG A  97
MET A 202
MET A 134
PHE A 177
 None
 1.45A 1y0xX-3pfnA:
undetectable		 1y0xX-3pfnA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qg5 RAD50

(Thermotoga
maritima) 		PF13476
(AAA_23)
PF13558
(SbcCD_C) 		5 ILE A 777
ALA A 773
ARG A 741
LEU A 821
PHE A 827
 None
 1.32A 1y0xX-3qg5A:
undetectable		 1y0xX-3qg5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2) 		5 ALA C  32
LEU C  83
ILE C  85
PHE C  70
PHE C  51
 None
 1.40A 1y0xX-3t6qC:
undetectable		 1y0xX-3t6qC:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00180
(Iso_dh) 		5 ILE A   7
ALA A  73
LEU A  32
ILE A 325
PHE A  42
 None
 1.38A 1y0xX-3ty4A:
undetectable		 1y0xX-3ty4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn4 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 13

(Homo sapiens) 		PF00090
(TSP_1) 		5 ILE A 673
ALA A 586
ARG A 639
ILE A 611
PHE A 573
 None
 1.45A 1y0xX-3vn4A:
undetectable		 1y0xX-3vn4A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnp HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00132
(Hexapep) 		5 ILE A 114
ALA A 112
ARG A 155
LEU A  85
ILE A  73
 None
 1.18A 1y0xX-3vnpA:
undetectable		 1y0xX-3vnpA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ARG A 453
LEU A 344
ILE A 121
PHE A 163
PHE A 170
 None
 1.40A 1y0xX-4aj9A:
undetectable		 1y0xX-4aj9A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2t DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 ILE A 417
ALA A 400
ARG A 403
LEU A 430
PHE A 467
 None
 1.44A 1y0xX-4c2tA:
undetectable		 1y0xX-4c2tA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		5 ILE A 185
MET A 164
LEU A  72
ILE A  76
PHE A  34
 None
 1.37A 1y0xX-4c90A:
undetectable		 1y0xX-4c90A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ILE A 110
ALA A 783
ARG A1019
ILE A1005
PHE A 119
 None
 1.31A 1y0xX-4f4cA:
undetectable		 1y0xX-4f4cA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hw8 BACTERIAL
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, PUTATIVE

(Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		5 MET A 375
LEU A 224
ILE A 410
PHE A 205
PHE A 197
 None
 1.36A 1y0xX-4hw8A:
undetectable		 1y0xX-4hw8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 1.10A 1y0xX-4m38A:
undetectable		 1y0xX-4m38A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb5 CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18)
PF16403
(DUF5011) 		5 ILE A 101
ARG A 109
LEU A  86
ILE A  90
PHE A 145
 None
 1.27A 1y0xX-4mb5A:
undetectable		 1y0xX-4mb5A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntl LIPOPROTEIN, YAEC
FAMILY

(Enterococcus
faecalis) 		PF03180
(Lipoprotein_9) 		5 ILE A 177
ALA A 131
MET A 198
ILE A 217
PHE A 179
 None
 1.31A 1y0xX-4ntlA:
undetectable		 1y0xX-4ntlA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oje EFF-1A

(Caenorhabditis
elegans) 		PF14884
(EFF-AFF) 		5 ALA H  73
LEU H 246
ILE H 233
PHE H 403
PHE H  66
 None
 1.16A 1y0xX-4ojeH:
undetectable		 1y0xX-4ojeH:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo2 CHLOROPHENOL-4-MONOO
XYGENASE

(Streptomyces
globisporus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		5 ILE A 106
ALA A 107
ARG A 111
ARG A 350
PHE A  89
 None
 1.31A 1y0xX-4oo2A:
undetectable		 1y0xX-4oo2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rot ESTERASE A

(Streptococcus
pyogenes) 		PF00756
(Esterase) 		5 ILE A   6
ALA A   5
LEU A  99
PHE A 106
PHE A 107
 None
 1.37A 1y0xX-4rotA:
undetectable		 1y0xX-4rotA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0p LIPOYL SYNTHASE 2

(Thermosynechococcus
elongatus) 		PF04055
(Radical_SAM) 		5 ILE B 158
ALA B 161
MET B 123
LEU B  58
ILE B  89
 None
 1.28A 1y0xX-4u0pB:
undetectable		 1y0xX-4u0pB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18) 		5 ILE A 101
ARG A 109
LEU A  86
ILE A  90
PHE A 145
 None
None
None
ACT  A 410 (-4.8A)
None
 1.27A 1y0xX-4w5zA:
undetectable		 1y0xX-4w5zA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus sp.
JAMB750) 		PF02156
(Glyco_hydro_26) 		5 MET A 360
ARG A 356
LEU A 345
ILE A 348
PHE A 404
 None
 1.19A 1y0xX-4yn5A:
undetectable		 1y0xX-4yn5A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z45 ODORANT-BINDING
PROTEIN NRIBOBP3

(Nasonovia
ribisnigri) 		PF01395
(PBP_GOBP) 		5 ILE A  46
MET A   3
MET A 108
LEU A  67
ILE A  82
 None
 1.28A 1y0xX-4z45A:
undetectable		 1y0xX-4z45A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		5 ILE A 391
ALA A 387
LEU A 433
ILE A 408
PHE A 395
 None
 1.29A 1y0xX-5b3hA:
undetectable		 1y0xX-5b3hA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		5 ILE A  14
ALA A  17
LEU A 229
ILE A 225
PHE A 154
 None
 1.26A 1y0xX-5c65A:
undetectable		 1y0xX-5c65A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ILE A  93
ARG A 113
LEU A  77
ILE A  23
PHE A  88
 None
 1.15A 1y0xX-5ce6A:
undetectable		 1y0xX-5ce6A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		5 ILE A  92
ALA A  91
LEU A  33
ILE A  35
PHE A  82
 None
 1.31A 1y0xX-5d6aA:
undetectable		 1y0xX-5d6aA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 ILE A 481
ARG A 689
LEU A 601
PHE A 453
PHE A 544
 None
 1.25A 1y0xX-5dkxA:
undetectable		 1y0xX-5dkxA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		5 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.96A 1y0xX-5egeA:
undetectable		 1y0xX-5egeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 0.99A 1y0xX-5ekuA:
undetectable		 1y0xX-5ekuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Haemophilus
influenzae) 		PF00005
(ABC_tran) 		5 ILE A 553
ALA A 550
LEU A 571
HIS A 581
PHE A 585
 None
 1.45A 1y0xX-5eumA:
undetectable		 1y0xX-5eumA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 ILE A 337
ALA A 340
MET A 261
PHE A 244
PHE A 319
 None
 1.36A 1y0xX-5fxeA:
undetectable		 1y0xX-5fxeA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		5 ARG A 431
LEU A 466
ILE A 469
PHE A 333
PHE A 326
 None
 1.44A 1y0xX-5icqA:
undetectable		 1y0xX-5icqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idv LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Acinetobacter
baumannii) 		PF00005
(ABC_tran) 		5 ILE A 244
ALA A 241
LEU A 262
HIS A 272
PHE A 276
 None
 1.45A 1y0xX-5idvA:
undetectable		 1y0xX-5idvA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvf SITE-DETERMINING
PROTEIN

(Pseudomonas
aeruginosa) 		PF10609
(ParA) 		5 ILE A 117
ARG A 260
ARG A  40
ILE A  13
PHE A 114
 None
 1.42A 1y0xX-5jvfA:
undetectable		 1y0xX-5jvfA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mh5 D-2-HYDROXYACID
DEHYDROGENASE

(Haloferax
mediterranei) 		no annotation 5 ILE A 244
ALA A 245
ARG A 109
LEU A 249
PHE A 212
 None
 1.39A 1y0xX-5mh5A:
undetectable		 1y0xX-5mh5A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpt CITRININ POLYKETIDE
SYNTHASE

(Monascus
purpureus) 		PF08242
(Methyltransf_12) 		5 ILE A1931
ALA A1928
LEU A1874
ILE A1845
PHE A2103
 None
 1.40A 1y0xX-5mptA:
undetectable		 1y0xX-5mptA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpu PUTATIVE
UNCHARACTERIZED
PROTEIN

(Campylobacter
jejuni) 		PF05523
(FdtA) 		5 ILE A  39
MET A  99
LEU A  60
ILE A  91
PHE A 102
 None
 1.29A 1y0xX-5tpuA:
undetectable		 1y0xX-5tpuA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 ALA A  82
ARG A  21
ILE A  39
PHE A 146
PHE A 634
 None
 1.26A 1y0xX-5tusA:
undetectable		 1y0xX-5tusA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 ILE A 112
ALA A 222
LEU A  17
ILE A  20
PHE A   6
 None
 1.28A 1y0xX-5ujuA:
undetectable		 1y0xX-5ujuA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 ILE A 170
ALA A 137
LEU A 233
ILE A 235
PHE A 174
 None
 1.23A 1y0xX-5vemA:
undetectable		 1y0xX-5vemA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 5 ILE A 298
ALA A 367
ARG A 411
LEU A 327
ILE A 403
 None
EDO  A 604 (-3.7A)
None
None
None
 1.41A 1y0xX-5wi9A:
undetectable		 1y0xX-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o DNA DAMAGE
CHECKPOINT PROTEIN
LCD1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE G 215
ALA G 218
LEU G 359
ILE G 520
PHE G 298
 None
 1.35A 1y0xX-5x6oG:
undetectable		 1y0xX-5x6oG:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE B1212
ALA B1213
ARG B1215
HIS A  92
PHE A  95
 None
 1.32A 1y0xX-5xogB:
undetectable		 1y0xX-5xogB:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum) 		no annotation 5 ILE A  43
MET A  36
ARG A  91
LEU A  54
ILE A 115
 None
 1.43A 1y0xX-5z7rA:
undetectable		 1y0xX-5z7rA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B 200
ALA B 204
ARG B  18
PHE B 195
PHE B 192
 None
 1.33A 1y0xX-6c6lB:
undetectable		 1y0xX-6c6lB:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cun PROTEIN (ALPHA
SPECTRIN)

(Gallus gallus) 		PF00435
(Spectrin) 		4 ILE A 147
SER A 137
LEU A 214
ASN A 217
 None
 1.11A 1y0xX-1cunA:
undetectable		 1y0xX-1cunA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ

(Sinorhizobium
meliloti) 		PF00072
(Response_reg) 		4 ILE A 112
SER A  18
LEU A  23
ASN A  26
 None
 1.11A 1y0xX-1dbwA:
0.0		 1y0xX-1dbwA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcq PYK2-ASSOCIATED
PROTEIN BETA

(Mus musculus) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		4 ILE A 387
SER A 312
LEU A 316
ASN A 319
 None
 0.95A 1y0xX-1dcqA:
0.0		 1y0xX-1dcqA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivm LYSOZYME M

(Mus musculus) 		PF00062
(Lys) 		4 ILE A  93
ARG A  14
LEU A  12
ASN A  15
 None
 1.06A 1y0xX-1ivmA:
0.0		 1y0xX-1ivmA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ILE A 810
SER A 721
LEU A 773
ASN A 774
 None
 1.13A 1y0xX-1kqfA:
0.0		 1y0xX-1kqfA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kw2 VITAMIN D-BINDING
PROTEIN

(Homo sapiens) 		PF00273
(Serum_albumin)
PF09164
(VitD-bind_III) 		4 ILE A 261
SER A 234
ARG A 232
LEU A 262
 None
 1.20A 1y0xX-1kw2A:
0.6		 1y0xX-1kw2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 ILE A 159
ARG A 146
LEU A 140
ASN A 141
 None
 1.10A 1y0xX-1ldjA:
1.5		 1y0xX-1ldjA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ls4 APOLIPOPHORIN-III

(Locusta
migratoria) 		no annotation 4 ILE A  88
ARG A  82
LEU A  84
ASN A  85
 None
 1.10A 1y0xX-1ls4A:
undetectable		 1y0xX-1ls4A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 ILE A 298
SER A 388
ARG A 335
LEU A 337
 None
 1.17A 1y0xX-1mb9A:
0.0		 1y0xX-1mb9A:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ILE A 221
SER A 260
ARG A 262
LEU A 276
 None
IH5  A 600 ( 4.0A)
None
IH5  A 600 (-4.0A)
 0.21A 1y0xX-1navA:
37.3		 1y0xX-1navA:
83.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ
HYPOTHETICAL PROTEIN
PA3008

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF03846
(SulA)
PF12327
(FtsZ_C) 		4 ILE X 102
SER A 272
ARG X  76
LEU X 103
 None
 1.06A 1y0xX-1ofuX:
undetectable		 1y0xX-1ofuX:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxe NEURAL ZINC FINGER
TRANSCRIPTION FACTOR
1

(Rattus
norvegicus) 		PF01530
(zf-C2HC) 		4 ILE A  54
SER A  18
ARG A  39
LEU A  41
 ZN  A  64 ( 4.7A)
None
None
None
 1.20A 1y0xX-1pxeA:
undetectable		 1y0xX-1pxeA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0a ZN(II)-RESPONSIVE
REGULATOR OF ZNTA

(Escherichia
coli) 		PF09278
(MerR-DNA-bind) 		4 ILE A  70
SER A  60
ARG A  65
LEU A  67
 None
 1.10A 1y0xX-1q0aA:
undetectable		 1y0xX-1q0aA:
17.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ILE A 275
SER A 314
ARG A 316
LEU A 330
ASN A 331
 None
G24  A 462 ( 4.7A)
None
G24  A 462 ( 3.9A)
None
 0.53A 1y0xX-1q4xA:
37.5		 1y0xX-1q4xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 ILE A 122
SER A 134
LEU A 126
ASN A 123
 None
 1.11A 1y0xX-1rt8A:
undetectable		 1y0xX-1rt8A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj5 CONSERVED
HYPOTHETICAL PROTEIN
TM0160

(Thermotoga
maritima) 		PF02577
(DNase-RNase) 		4 ILE A 139
SER A 130
ARG A   2
LEU A  31
 None
 0.89A 1y0xX-1sj5A:
undetectable		 1y0xX-1sj5A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq5 PANTOTHENATE KINASE

(Escherichia
coli) 		PF00485
(PRK) 		4 ILE A1066
ARG A1060
LEU A1062
ASN A1063
 None
 1.12A 1y0xX-1sq5A:
undetectable		 1y0xX-1sq5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ILE A 100
ARG A  87
LEU A  99
ASN A  98
 None
 1.20A 1y0xX-1w99A:
undetectable		 1y0xX-1w99A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 ILE B 222
SER B 164
LEU B 209
ASN B 211
 None
 1.15A 1y0xX-1wytB:
undetectable		 1y0xX-1wytB:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 ILE A   6
SER A  68
LEU A  39
ASN A  42
 None
 1.04A 1y0xX-1yrgA:
undetectable		 1y0xX-1yrgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ILE A 154
SER A 185
ARG A 186
LEU A 155
 None
 1.17A 1y0xX-1yx2A:
undetectable		 1y0xX-1yx2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ILE A 198
ARG A 676
LEU A 740
ASN A 736
 None
 1.03A 1y0xX-2ivfA:
undetectable		 1y0xX-2ivfA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kay PROTEIN S100-A5

(Homo sapiens) 		PF01023
(S_100) 		4 ILE A  38
SER A  20
ARG A  22
LEU A  34
 None
CA  A 186 (-3.9A)
None
None
 1.02A 1y0xX-2kayA:
undetectable		 1y0xX-2kayA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ke7 ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF00536
(SAM_1) 		4 ILE A 871
SER A 861
ARG A 866
LEU A 868
 None
 1.04A 1y0xX-2ke7A:
undetectable		 1y0xX-2ke7A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfy HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN F

(Homo sapiens) 		no annotation 4 ILE A  36
SER A  88
ARG A  90
LEU A  61
 None
 1.12A 1y0xX-2kfyA:
undetectable		 1y0xX-2kfyA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwx MATRIX PROTEIN 2

(Influenza A
virus) 		PF00599
(Flu_M2) 		4 ILE A  39
SER A  50
ARG A  45
LEU A  43
 None
 1.01A 1y0xX-2kwxA:
undetectable		 1y0xX-2kwxA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kym BUD EMERGENCE
PROTEIN 1

(Lodderomyces
elongisporus) 		PF00018
(SH3_1) 		4 ILE A  42
SER A  21
LEU A  26
ASN A  25
 None
 1.07A 1y0xX-2kymA:
undetectable		 1y0xX-2kymA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		4 ILE B 191
SER B 172
LEU B 194
ASN B 219
 None
 1.17A 1y0xX-2p1nB:
undetectable		 1y0xX-2p1nB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qed HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 ILE A 161
SER A 119
ARG A 120
LEU A 123
 None
 1.17A 1y0xX-2qedA:
undetectable		 1y0xX-2qedA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkq PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-SD

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 ILE A 109
SER A  91
ARG A  90
LEU A 107
 None
 1.09A 1y0xX-2rkqA:
undetectable		 1y0xX-2rkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcz PROTEIN MEMO1

(Homo sapiens) 		PF01875
(Memo) 		4 ILE A 133
SER A 123
ARG A 121
LEU A 157
 None
 1.14A 1y0xX-3bczA:
undetectable		 1y0xX-3bczA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkn BACTERIOFERRITIN

(Mycolicibacterium
smegmatis) 		PF00210
(Ferritin) 		4 ILE A  62
ARG A  73
LEU A  15
ASN A  12
 None
 1.18A 1y0xX-3bknA:
undetectable		 1y0xX-3bknA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN BETA
CHAIN
FIBRINOGEN GAMMA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ILE B 179
SER B 170
LEU B 175
ASN C 117
 None
 1.05A 1y0xX-3bvhB:
undetectable		 1y0xX-3bvhB:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF14587
(Glyco_hydr_30_2) 		4 ILE A 355
SER A 469
LEU A 359
ASN A 356
 None
 1.14A 1y0xX-3clwA:
undetectable		 1y0xX-3clwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 ILE A 474
SER A  17
LEU A 479
ASN A 478
 None
 1.10A 1y0xX-3cmmA:
undetectable		 1y0xX-3cmmA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		4 ILE A 533
SER A 364
LEU A 527
ASN A 530
 None
 1.13A 1y0xX-3cskA:
undetectable		 1y0xX-3cskA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		4 ILE B  35
SER B  95
LEU B  32
ASN B 103
 None
 1.11A 1y0xX-3draB:
undetectable		 1y0xX-3draB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9d ZGC:56074

(Danio rerio) 		PF00300
(His_Phos_1) 		4 ILE A 244
SER A 182
ARG A  10
ASN A 245
 None
None
PO4  A 267 ( 2.9A)
None
 0.97A 1y0xX-3e9dA:
undetectable		 1y0xX-3e9dA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 ILE A 209
SER A 201
ARG A 204
LEU A 206
 None
 1.09A 1y0xX-3egwA:
undetectable		 1y0xX-3egwA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5b AMINOGLYCOSIDE
N(6')ACETYLTRANSFERA
SE

(Legionella
pneumophila) 		PF13523
(Acetyltransf_8) 		4 ILE A  34
SER A  44
LEU A  38
ASN A  35
 None
 1.18A 1y0xX-3f5bA:
undetectable		 1y0xX-3f5bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkm OS03G0854200 PROTEIN

(Oryza sativa) 		PF01138
(RNase_PH) 		4 SER A 219
ARG A 221
LEU A 153
ASN A  12
 None
 1.06A 1y0xX-3hkmA:
undetectable		 1y0xX-3hkmA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hur ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 337
SER A 254
ARG A 333
LEU A 336
 None
 1.18A 1y0xX-3hurA:
undetectable		 1y0xX-3hurA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j26 CAPSID PROTEIN V20

(Mimivirus-dependent
virus Sputnik) 		no annotation 4 ILE A 472
SER A  58
LEU A 225
ASN A 115
 None
 0.94A 1y0xX-3j26A:
undetectable		 1y0xX-3j26A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k33 DEATH ON CURING
PROTEIN

(Escherichia
virus P1) 		PF02661
(Fic) 		4 SER A  79
ARG A  86
LEU A  84
ASN A  87
 None
 1.16A 1y0xX-3k33A:
undetectable		 1y0xX-3k33A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kar KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		4 ILE A 649
SER A 713
LEU A 653
ASN A 650
 None
 1.19A 1y0xX-3karA:
undetectable		 1y0xX-3karA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l1c KINESIN-14 NCD

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 ILE A 599
SER A 660
LEU A 603
ASN A 600
 None
 1.20A 1y0xX-3l1cA:
undetectable		 1y0xX-3l1cA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A

(Shewanella
denitrificans) 		PF00246
(Peptidase_M14) 		4 ILE A 275
ARG A 227
LEU A 316
ASN A 321
 None
UNL  A 378 ( 2.8A)
None
None
 1.17A 1y0xX-3l2nA:
undetectable		 1y0xX-3l2nA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE

(Saccharomyces
cerevisiae) 		PF00282
(Pyridoxal_deC) 		4 ILE C 488
SER C 539
LEU C 486
ASN C 487
 None
 1.20A 1y0xX-3mc6C:
undetectable		 1y0xX-3mc6C:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		4 ILE A 307
SER A 321
LEU A 311
ASN A 308
 None
 1.08A 1y0xX-3r5tA:
undetectable		 1y0xX-3r5tA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 ILE A 665
SER A 717
ARG A 659
LEU A 663
 None
 1.18A 1y0xX-3texA:
undetectable		 1y0xX-3texA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uau SURFACE-EXPOSED
LIPOPROTEIN

(Campylobacter
jejuni) 		PF16668
(JLPA) 		4 ILE A  94
SER A 128
ARG A  97
LEU A 130
 None
 1.20A 1y0xX-3uauA:
undetectable		 1y0xX-3uauA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ud2 ANKYRIN-1

(Homo sapiens) 		no annotation 4 ILE C 993
SER C 929
ARG C 927
LEU C 934
 None
 1.04A 1y0xX-3ud2C:
undetectable		 1y0xX-3ud2C:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2n 70 KDA PROTEIN

(Xanthomonas sp.
35Y) 		no annotation 4 ILE A 381
SER A 389
ARG A 370
ASN A 378
 None
 1.19A 1y0xX-4b2nA:
undetectable		 1y0xX-4b2nA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)

(Legionella
pneumophila) 		PF00351
(Biopterin_H) 		4 ILE A  61
SER A  68
ARG A  70
LEU A 124
 None
 1.07A 1y0xX-4bptA:
undetectable		 1y0xX-4bptA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		4 ILE A 576
SER A 567
ARG A 571
LEU A 573
 None
 1.13A 1y0xX-4bzkA:
undetectable		 1y0xX-4bzkA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccy CARBOXYLESTERASE
YBFK

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		4 ILE B 201
SER B 213
ARG B 212
LEU B  65
 None
 1.07A 1y0xX-4ccyB:
undetectable		 1y0xX-4ccyB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3n DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis) 		PF03989
(DNA_gyraseA_C) 		4 ILE A 767
SER A 675
LEU A 672
ASN A 715
 None
 1.01A 1y0xX-4g3nA:
undetectable		 1y0xX-4g3nA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkx BETA-GALACTOSIDE-SPE
CIFIC LECTIN 1 A
CHAIN

(Viscum album) 		PF00161
(RIP) 		4 ILE A  70
SER A  29
ARG A  41
LEU A  75
 None
None
DIO  A 307 (-4.4A)
None
 0.92A 1y0xX-4jkxA:
undetectable		 1y0xX-4jkxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 ILE A1061
SER A1023
ARG A1025
LEU A1030
 None
 1.14A 1y0xX-4kf7A:
undetectable		 1y0xX-4kf7A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Escherichia
coli) 		PF02733
(Dak1) 		4 ILE A 316
ARG A 313
LEU A 315
ASN A 314
 None
 1.20A 1y0xX-4lryA:
undetectable		 1y0xX-4lryA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxo FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		4 ILE A1354
ARG A1403
LEU A1400
ASN A1401
 None
 1.13A 1y0xX-4lxoA:
undetectable		 1y0xX-4lxoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 ILE A  14
SER A 105
LEU A 134
ASN A 133
 None
 1.17A 1y0xX-4my5A:
undetectable		 1y0xX-4my5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF13439
(Glyco_transf_4)
PF13692
(Glyco_trans_1_4) 		4 ILE A 225
SER A 262
ARG A 186
LEU A 192
 None
 1.17A 1y0xX-4n9wA:
undetectable		 1y0xX-4n9wA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 ILE A 408
SER A 189
LEU A 418
ASN A 417
 None
 1.16A 1y0xX-4pv4A:
undetectable		 1y0xX-4pv4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A 299
ARG A 259
LEU A 288
ASN A 292
 None
 1.11A 1y0xX-4tz0A:
undetectable		 1y0xX-4tz0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u65 TWO COMPONENT
HISTIDINE KINASE,
GGDEF DOMAIN
PROTEIN/EAL DOMAIN
PROTEIN

(Legionella
pneumophila) 		PF16448
(LapD_MoxY_N) 		4 ILE A  58
SER A 120
LEU A  53
ASN A  59
 None
 1.19A 1y0xX-4u65A:
undetectable		 1y0xX-4u65A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa9 GALA PROTEIN TYPE 1,
3 OR 4

(Legionella
pneumophila) 		PF13516
(LRR_6) 		4 ILE A 235
SER A 201
LEU A 229
ASN A 232
 None
 1.02A 1y0xX-4xa9A:
undetectable		 1y0xX-4xa9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xze NUCLEOPROTEIN

(Hazara
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 ILE A 433
SER A 173
ARG A 178
LEU A 458
 None
 1.12A 1y0xX-4xzeA:
undetectable		 1y0xX-4xzeA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgs PUTATIVE D-LACTATE
DEHYDROGENASE

(Chlamydomonas
reinhardtii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A 272
SER A 244
ARG A 246
LEU A 271
 None
NAD  A1000 (-2.1A)
None
None
 1.18A 1y0xX-4zgsA:
undetectable		 1y0xX-4zgsA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		4 ILE A 260
ARG A 254
LEU A 256
ASN A 257
 None
 1.01A 1y0xX-5b1qA:
undetectable		 1y0xX-5b1qA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvl DESIGNED TIM BARREL
STIM11

(synthetic
construct) 		no annotation 4 ILE A  66
SER A  24
ARG A  23
LEU A  41
 None
 1.16A 1y0xX-5bvlA:
undetectable		 1y0xX-5bvlA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 ILE A  24
ARG A  54
LEU A  52
ASN A  55
 None
CD  A 505 (-2.7A)
None
None
 1.16A 1y0xX-5bzaA:
undetectable		 1y0xX-5bzaA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdh MAJOR ACID
PHOSPHATASE

(Legionella
pneumophila) 		PF00328
(His_Phos_2) 		4 ILE A  92
SER A  96
ARG A  95
LEU A 276
 None
 1.14A 1y0xX-5cdhA:
undetectable		 1y0xX-5cdhA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cws NUCLEOPORIN NSP1
NUCLEOPORIN NUP49

(Chaetomium
thermophilum) 		PF05064
(Nsp1_C)
no annotation 		4 ILE D 283
ARG C 497
LEU C 499
ASN C 502
 None
 1.15A 1y0xX-5cwsD:
undetectable		 1y0xX-5cwsD:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		4 ILE A  49
SER A  75
ARG A  42
LEU A  46
 None
 1.07A 1y0xX-5cykA:
undetectable		 1y0xX-5cykA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza C
virus) 		PF00603
(Flu_PA) 		4 ILE A 287
SER A 275
ARG A 279
LEU A 286
 None
 1.11A 1y0xX-5d9aA:
undetectable		 1y0xX-5d9aA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		4 ILE A 940
ARG A 979
LEU A 977
ASN A 980
 None
 1.18A 1y0xX-5dztA:
undetectable		 1y0xX-5dztA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5

(Saccharomyces
cerevisiae) 		PF12717
(Cnd1) 		4 ILE A 523
SER A 641
LEU A 583
ASN A 584
 None
 1.15A 1y0xX-5frsA:
undetectable		 1y0xX-5frsA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h12 DEEP VENT DNA
POLYMERASE

(Pyrococcus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ILE A 568
SER A 412
LEU A 572
ASN A 569
 None
 1.19A 1y0xX-5h12A:
undetectable		 1y0xX-5h12A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h65 PROTECTION OF
TELOMERES PROTEIN 1

(Homo sapiens) 		no annotation 4 ILE A 474
SER A 507
ARG A 510
LEU A 485
 None
 1.18A 1y0xX-5h65A:
undetectable		 1y0xX-5h65A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5il7 RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF12799
(LRR_4)
PF13516
(LRR_6) 		4 ILE A 207
ARG A 226
LEU A 224
ASN A 227
 None
 1.15A 1y0xX-5il7A:
undetectable		 1y0xX-5il7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it9 RIBOSOMAL PROTEIN
ES19

(Kluyveromyces
lactis) 		PF01090
(Ribosomal_S19e) 		4 ILE T 135
SER T 125
ARG T 130
LEU T 132
 None
None
G  21357 ( 4.6A)
None
 1.13A 1y0xX-5it9T:
undetectable		 1y0xX-5it9T:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nof ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermococcus
kodakarensis) 		no annotation 4 ILE A 124
ARG A 130
LEU A 122
ASN A 123
 None
 1.15A 1y0xX-5nofA:
undetectable		 1y0xX-5nofA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ods CLATHRIN HEAVY CHAIN
1

(Mus musculus) 		no annotation 4 ILE A   4
ARG A   8
LEU A   5
ASN A 333
 None
 1.00A 1y0xX-5odsA:
undetectable		 1y0xX-5odsA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 2
CONDENSIN COMPLEX
SUBUNIT 3

(Schizosaccharomyces
pombe) 		no annotation 4 ILE A 631
SER C 525
ARG C 527
LEU C 529
 None
 1.12A 1y0xX-5oqrA:
undetectable		 1y0xX-5oqrA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 ILE 4 415
SER 4 335
ARG 4 334
LEU 4 417
 None
 1.09A 1y0xX-5u8s4:
undetectable		 1y0xX-5u8s4:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		PF13281
(DUF4071) 		4 ILE A 315
ARG A 281
LEU A 319
ASN A 316
 None
 1.06A 1y0xX-5ulmA:
undetectable		 1y0xX-5ulmA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Lassa
mammarenavirus) 		PF00798
(Arena_glycoprot) 		4 ILE a 337
SER A 246
ARG A 248
ASN a 338
 None
 0.88A 1y0xX-5vk2a:
undetectable		 1y0xX-5vk2a:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 ILE A 597
SER A 577
ARG A 528
LEU A 596
 None
 1.16A 1y0xX-5vocA:
undetectable		 1y0xX-5vocA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vso YEAST DNAJ PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A  15
SER A  63
ARG A  68
LEU A  16
 None
 1.13A 1y0xX-5vsoA:
undetectable		 1y0xX-5vsoA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcx VL-SARAH(S37C)
CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		4 ILE B  29
SER B  52
ARG B  50
LEU B  33
 None
 0.98A 1y0xX-5xcxB:
undetectable		 1y0xX-5xcxB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF04212
(MIT) 		4 ILE A 252
SER A 284
ARG A 288
LEU A 256
 None
 1.09A 1y0xX-5xmiA:
undetectable		 1y0xX-5xmiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED

(Oryza sativa) 		no annotation 4 ILE A 237
SER A 334
ARG A 335
LEU A 257
 None
 1.16A 1y0xX-5xoiA:
undetectable		 1y0xX-5xoiA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 ILE B  72
SER B  93
ARG B 103
LEU B  77
 None
None
GOL  B 406 (-4.1A)
None
 1.17A 1y0xX-5y6qB:
undetectable		 1y0xX-5y6qB:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 4 ILE A  68
SER A 113
ARG A 100
LEU A 102
 None
 1.01A 1y0xX-5ybbA:
undetectable		 1y0xX-5ybbA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN

(Homo sapiens) 		no annotation 4 SER A  45
ARG A  44
LEU A 306
ASN A 307
 None
 1.17A 1y0xX-5yy8A:
undetectable		 1y0xX-5yy8A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11

(Homo sapiens) 		no annotation 4 ILE A  30
ARG A  51
LEU A  34
ASN A  33
 None
 1.02A 1y0xX-6ba5A:
undetectable		 1y0xX-6ba5A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11

(Homo sapiens) 		no annotation 4 ILE A  30
SER A  53
LEU A  34
ASN A  33
 None
 1.09A 1y0xX-6ba5A:
undetectable		 1y0xX-6ba5A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA

(Pyrococcus
furiosus) 		no annotation 4 ILE L 371
ARG L 342
LEU L 349
ASN L 348
 None
 0.94A 1y0xX-6cfwL:
undetectable		 1y0xX-6cfwL:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbh HOPQ

(Helicobacter
pylori) 		no annotation 4 ILE C  64
SER C 329
LEU C  67
ASN C  68
 None
 1.19A 1y0xX-6gbhC:
undetectable		 1y0xX-6gbhC:
15.91