SIMILAR PATTERNS OF AMINO ACIDS FOR 1XZX_X_T3X500_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		3 PHE A 227
ARG A 249
ASN A 263
 None
 0.73A 1xzxX-1bxcA:
0.0		 1xzxX-1bxcA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 PHE A 470
ARG A 380
ASN A 396
 None
 0.59A 1xzxX-1d4eA:
0.0		 1xzxX-1d4eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj0 PSEUDOURIDINE
SYNTHASE I

(Escherichia
coli) 		PF01416
(PseudoU_synth_1) 		3 PHE A 161
ARG A 205
ASN A 206
 None
 0.70A 1xzxX-1dj0A:
0.0		 1xzxX-1dj0A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dv8 ASIALOGLYCOPROTEIN
RECEPTOR 1

(Homo sapiens) 		PF00059
(Lectin_C) 		3 PHE A 257
ARG A 270
ASN A 208
 None
CL  A1004 (-4.4A)
None
 0.87A 1xzxX-1dv8A:
0.0		 1xzxX-1dv8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ft4 SOLUBLE TUMOR
NECROSIS FACTOR
RECEPTOR 1

(Homo sapiens) 		PF00020
(TNFR_c6) 		3 PHE A  60
ARG A  68
ASN A  65
 703  A 962 ( 4.9A)
None
None
 0.86A 1xzxX-1ft4A:
undetectable		 1xzxX-1ft4A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		3 PHE A 456
ARG A 397
ASN A 386
 None
 0.79A 1xzxX-1h39A:
0.0		 1xzxX-1h39A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 PHE B  71
ARG B 178
ASN B  65
 None
 0.91A 1xzxX-1hr7B:
0.0		 1xzxX-1hr7B:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		3 PHE A  99
ARG A 328
ASN A  91
 None
 0.88A 1xzxX-1kp2A:
undetectable		 1xzxX-1kp2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 PHE A  30
ARG A  21
ASN A 106
 None
 0.93A 1xzxX-1kpiA:
0.0		 1xzxX-1kpiA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ljy MGP-40

(Capra hircus) 		PF00704
(Glyco_hydro_18) 		3 PHE A  85
ARG A  96
ASN A  43
 None
 0.92A 1xzxX-1ljyA:
undetectable		 1xzxX-1ljyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 PHE A 353
ARG A 364
ASN A 238
 RS7  A 841 (-4.7A)
None
None
 0.81A 1xzxX-1loxA:
undetectable		 1xzxX-1loxA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		3 PHE A 257
ARG A 177
ASN A 112
 None
 0.92A 1xzxX-1mnnA:
undetectable		 1xzxX-1mnnA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		3 PHE A 433
ARG A 143
ASN A 382
 None
 0.87A 1xzxX-1mqqA:
undetectable		 1xzxX-1mqqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 PHE A  12
ARG A  59
ASN A  14
 None
 0.89A 1xzxX-1np7A:
undetectable		 1xzxX-1np7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvg DNA TOPOISOMERASE II

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		3 PHE A 304
ARG A 287
ASN A 306
 None
 0.87A 1xzxX-1pvgA:
undetectable		 1xzxX-1pvgA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 PHE A 272
ARG A 316
ASN A 331
 G24  A 462 (-4.9A)
None
None
 0.56A 1xzxX-1q4xA:
37.5		 1xzxX-1q4xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxq YFIT

(Bacillus
subtilis) 		PF12867
(DinB_2) 		3 PHE A  79
ARG A  91
ASN A  74
 None
 0.93A 1xzxX-1rxqA:
undetectable		 1xzxX-1rxqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		3 PHE A 203
ARG A 501
ASN A 209
 None
 0.89A 1xzxX-1sy7A:
undetectable		 1xzxX-1sy7A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA) 		3 PHE A  70
ARG A 266
ASN A 124
 None
SO4  A 321 (-3.6A)
SO4  A 321 (-3.0A)
 0.89A 1xzxX-1tltA:
undetectable		 1xzxX-1tltA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 PHE A 282
ARG A 409
ASN A 242
 FAD  A1601 (-4.1A)
None
None
 0.92A 1xzxX-1v5fA:
undetectable		 1xzxX-1v5fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vff BETA-GLUCOSIDASE

(Pyrococcus
horikoshii) 		PF00232
(Glyco_hydro_1) 		3 PHE A 118
ARG A  75
ASN A  27
 None
 0.93A 1xzxX-1vffA:
undetectable		 1xzxX-1vffA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		3 PHE A 644
ARG A 662
ASN A 646
 None
 0.85A 1xzxX-1vrqA:
undetectable		 1xzxX-1vrqA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wjp ZINC FINGER PROTEIN
295

(Homo sapiens) 		no annotation 3 PHE A  53
ARG A  20
ASN A  23
 None
 0.84A 1xzxX-1wjpA:
undetectable		 1xzxX-1wjpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 PHE A 217
ARG A 245
ASN A 267
 None
 0.89A 1xzxX-1xkhA:
undetectable		 1xzxX-1xkhA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynx REPLICATION FACTOR-A
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF01336
(tRNA_anti-codon) 		3 PHE A 222
ARG A 282
ASN A 279
 None
 0.63A 1xzxX-1ynxA:
undetectable		 1xzxX-1ynxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2a RAS-RELATED PROTEIN
RAB-23

(Mus musculus) 		PF00071
(Ras) 		3 PHE A 162
ARG A 149
ASN A 157
 None
 0.85A 1xzxX-1z2aA:
undetectable		 1xzxX-1z2aA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 PHE C 264
ARG C  94
ASN C  99
 None
HEM  C 501 (-2.7A)
None
 0.94A 1xzxX-1zrtC:
undetectable		 1xzxX-1zrtC:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwq REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2

(Rattus
norvegicus) 		PF00168
(C2) 		3 PHE A 798
ARG A 811
ASN A 779
 None
 0.82A 1xzxX-2bwqA:
undetectable		 1xzxX-2bwqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01156
(IU_nuc_hydro) 		3 PHE A 175
ARG A 156
ASN A 160
 None
None
RIB  A1312 (-3.3A)
 0.91A 1xzxX-2c40A:
undetectable		 1xzxX-2c40A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		3 PHE A 351
ARG A 367
ASN A 374
 None
 0.90A 1xzxX-2d7dA:
undetectable		 1xzxX-2d7dA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4o PEPTIDE N-GLYCANASE

(Mus musculus) 		PF01841
(Transglut_core) 		3 PHE A 289
ARG A 255
ASN A 277
 None
 0.88A 1xzxX-2f4oA:
undetectable		 1xzxX-2f4oA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		3 PHE A 645
ARG A 663
ASN A 647
 None
 0.84A 1xzxX-2gahA:
undetectable		 1xzxX-2gahA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3

(Homo sapiens) 		no annotation 3 PHE A 426
ARG A 415
ASN A 465
 None
 0.93A 1xzxX-2gkwA:
undetectable		 1xzxX-2gkwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)

(West Nile virus) 		PF00972
(Flavi_NS5) 		3 PHE A 685
ARG A 543
ASN A 687
 None
 0.86A 1xzxX-2hcsA:
undetectable		 1xzxX-2hcsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iae SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		3 PHE B  53
ARG B 105
ASN B 102
 None
 0.86A 1xzxX-2iaeB:
undetectable		 1xzxX-2iaeB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		3 PHE A 217
ARG A 245
ASN A 267
 None
 0.90A 1xzxX-2o5pA:
undetectable		 1xzxX-2o5pA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 3 PHE A 880
ARG A 318
ASN A 319
 None
 0.68A 1xzxX-2po4A:
undetectable		 1xzxX-2po4A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		3 PHE A 214
ARG A 171
ASN A 172
 None
 0.92A 1xzxX-2pziA:
undetectable		 1xzxX-2pziA:
17.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		3 PHE A 312
ARG A 301
ASN A 181
 None
 0.94A 1xzxX-2q60A:
19.5		 1xzxX-2q60A:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 PHE A 290
ARG A 268
ASN A 318
 None
 0.76A 1xzxX-2wyaA:
undetectable		 1xzxX-2wyaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PHE A  58
ARG A  49
ASN A  83
 None
 0.75A 1xzxX-2yfkA:
undetectable		 1xzxX-2yfkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PHE A  58
ARG A 394
ASN A  83
 None
 0.67A 1xzxX-2yfkA:
undetectable		 1xzxX-2yfkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygt DELTA TOXIN

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		3 PHE A 175
ARG A  86
ASN A 251
 None
 0.85A 1xzxX-2ygtA:
undetectable		 1xzxX-2ygtA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 PHE A1247
ARG A1251
ASN A1218
 None
 0.84A 1xzxX-2zxqA:
undetectable		 1xzxX-2zxqA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3l KETOHEXOKINASE

(Homo sapiens) 		PF00294
(PfkB) 		3 PHE A 190
ARG A 141
ASN A  42
 None
 0.64A 1xzxX-3b3lA:
undetectable		 1xzxX-3b3lA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 3 PHE A  35
ARG A 369
ASN A 362
 None
 0.83A 1xzxX-3cv3A:
undetectable		 1xzxX-3cv3A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzt D7 PROTEIN

(Aedes aegypti) 		PF01395
(PBP_GOBP) 		3 PHE A 110
ARG A  57
ASN A  20
 None
 0.76A 1xzxX-3dztA:
undetectable		 1xzxX-3dztA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 PHE A1206
ARG A1210
ASN A1177
 None
 0.83A 1xzxX-3ecqA:
undetectable		 1xzxX-3ecqA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		3 PHE A 100
ARG A  83
ASN A 106
 None
EDO  A 534 (-4.1A)
None
 0.89A 1xzxX-3f6tA:
undetectable		 1xzxX-3f6tA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 PHE A 389
ARG A 375
ASN A 374
 None
 0.91A 1xzxX-3g1uA:
undetectable		 1xzxX-3g1uA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 PHE B1119
ARG A 452
ASN A 494
 None
 0.79A 1xzxX-3h0gB:
undetectable		 1xzxX-3h0gB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 PHE A  58
ARG A 165
ASN A  52
 None
 0.76A 1xzxX-3h1lA:
undetectable		 1xzxX-3h1lA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4u ATP-DEPENDENT RNA
HELICASE DHX8

(Homo sapiens) 		PF04408
(HA2)
PF07717
(OB_NTP_bind) 		3 PHE A1035
ARG A1079
ASN A1050
 None
GOL  A  11 (-4.0A)
None
 0.78A 1xzxX-3i4uA:
undetectable		 1xzxX-3i4uA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9f PUTATIVE TYPE 11
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF08241
(Methyltransf_11) 		3 PHE A  95
ARG A 141
ASN A  97
 None
 0.80A 1xzxX-3i9fA:
undetectable		 1xzxX-3i9fA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF05960
(DUF885) 		3 PHE A 458
ARG A 471
ASN A 489
 None
 0.87A 1xzxX-3iukA:
undetectable		 1xzxX-3iukA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 PHE A 366
ARG A  56
ASN A 383
 None
 0.72A 1xzxX-3iv0A:
undetectable		 1xzxX-3iv0A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		3 PHE A 227
ARG A 240
ASN A 229
 None
 0.63A 1xzxX-3jbhA:
undetectable		 1xzxX-3jbhA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngf AP ENDONUCLEASE,
FAMILY 2

(Brucella
abortus) 		PF01261
(AP_endonuc_2) 		3 PHE A  12
ARG A 210
ASN A   7
 None
 0.74A 1xzxX-3ngfA:
undetectable		 1xzxX-3ngfA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		3 PHE A 225
ARG A 222
ASN A 238
 None
 0.93A 1xzxX-3o5dA:
undetectable		 1xzxX-3o5dA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q98 TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PHE A  58
ARG A  49
ASN A  83
 None
 0.82A 1xzxX-3q98A:
undetectable		 1xzxX-3q98A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q98 TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PHE A  58
ARG A 394
ASN A  83
 None
 0.90A 1xzxX-3q98A:
undetectable		 1xzxX-3q98A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk3 BETA-CRYSTALLIN B3

(Homo sapiens) 		PF00030
(Crystall) 		3 PHE A 124
ARG A 127
ASN A 121
 None
 0.93A 1xzxX-3qk3A:
undetectable		 1xzxX-3qk3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		3 PHE A 353
ARG A 364
ASN A 238
 None
 0.83A 1xzxX-3rdeA:
undetectable		 1xzxX-3rdeA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9

(Veillonella
parvula) 		PF01075
(Glyco_transf_9) 		3 PHE A 187
ARG A 197
ASN A 265
 None
 0.84A 1xzxX-3tovA:
undetectable		 1xzxX-3tovA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaj ENVELOPE PROTEIN

(Dengue virus) 		no annotation 3 PHE B 193
ARG B 167
ASN B 134
 None
 0.76A 1xzxX-3uajB:
undetectable		 1xzxX-3uajB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ud2 ANKYRIN-1

(Homo sapiens) 		no annotation 3 PHE C1203
ARG C1143
ASN C1206
 None
 0.95A 1xzxX-3ud2C:
undetectable		 1xzxX-3ud2C:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj1 THIOREDOXIN
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 PHE A 332
ARG A 385
ASN A 386
 None
 0.91A 1xzxX-3uj1A:
undetectable		 1xzxX-3uj1A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1e FLAGELLA BASAL-BODY
PROTEIN

(Vibrio
alginolyticus) 		PF16538
(FlgT_C)
PF16539
(FlgT_M)
PF16548
(FlgT_N) 		3 PHE A 141
ARG A 132
ASN A 131
 None
 0.90A 1xzxX-3w1eA:
undetectable		 1xzxX-3w1eA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		3 PHE A 446
ARG A 449
ASN A 499
 None
 0.83A 1xzxX-3x3yA:
undetectable		 1xzxX-3x3yA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 PHE A1160
ARG A 947
ASN A 892
 None
 0.75A 1xzxX-3zyvA:
undetectable		 1xzxX-3zyvA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 PHE A 467
ARG A 189
ASN A 155
 None
 0.93A 1xzxX-4b90A:
undetectable		 1xzxX-4b90A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		3 PHE A 304
ARG A 287
ASN A 306
 None
 0.92A 1xzxX-4gfhA:
1.3		 1xzxX-4gfhA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE

(Thermotoga
maritima) 		PF09861
(DUF2088) 		3 PHE A 101
ARG A 136
ASN A 135
 None
 0.71A 1xzxX-4narA:
undetectable		 1xzxX-4narA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		3 PHE B 716
ARG B 597
ASN B 598
 None
 0.85A 1xzxX-4oavB:
undetectable		 1xzxX-4oavB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on0 NOLR

(Sinorhizobium
fredii) 		PF01022
(HTH_5) 		3 PHE A  22
ARG A  67
ASN A  70
 None
 0.95A 1xzxX-4on0A:
undetectable		 1xzxX-4on0A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 PHE A  78
ARG A 256
ASN A 325
 None
 0.86A 1xzxX-4p13A:
undetectable		 1xzxX-4p13A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN

(Sulfurospirillum
deleyianum) 		PF01497
(Peripla_BP_2) 		3 PHE A 338
ARG A 293
ASN A 283
 None
 0.71A 1xzxX-4pagA:
undetectable		 1xzxX-4pagA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qma CYSTEINE DIOXYGENASE
TYPE I

(Cupriavidus
pinatubonensis) 		PF05995
(CDO_I) 		3 PHE A  83
ARG A 130
ASN A 151
 OXY  A 302 (-4.5A)
None
None
 0.92A 1xzxX-4qmaA:
undetectable		 1xzxX-4qmaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r30 LAFORIN

(Homo sapiens) 		PF00782
(DSPc) 		3 PHE A 192
ARG A 171
ASN A 267
 None
None
SO4  A 501 (-4.6A)
 0.87A 1xzxX-4r30A:
undetectable		 1xzxX-4r30A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN

(Homo sapiens) 		PF00628
(PHD) 		3 PHE A1238
ARG A 356
ASN A1244
 None
 0.93A 1xzxX-4up5A:
undetectable		 1xzxX-4up5A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		3 PHE A2212
ARG A2202
ASN A2205
 None
 0.90A 1xzxX-4x0qA:
undetectable		 1xzxX-4x0qA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yiv APICAL MEMBRANE
ANTIGEN AMA1

(Toxoplasma
gondii) 		PF02430
(AMA-1) 		3 PHE A  85
ARG A 369
ASN A 370
 None
 0.86A 1xzxX-4yivA:
undetectable		 1xzxX-4yivA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4

(Saccharomyces
cerevisiae) 		PF01793
(Glyco_transf_15) 		3 PHE A 267
ARG A 405
ASN A 416
 None
 0.94A 1xzxX-5a08A:
undetectable		 1xzxX-5a08A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 PHE A1206
ARG A1210
ASN A1177
 None
 0.90A 1xzxX-5a55A:
undetectable		 1xzxX-5a55A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bug PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
3-PHOSPHATASE AND
DUAL-SPECIFICITY
PROTEIN PHOSPHATASE
PTEN

(Homo sapiens) 		PF00782
(DSPc)
PF10409
(PTEN_C2) 		3 PHE A 271
ARG A 172
ASN A 329
 None
 0.92A 1xzxX-5bugA:
undetectable		 1xzxX-5bugA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8s GUANINE-N7
METHYLTRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		3 PHE B 426
ARG B  84
ASN B 410
 G3A  B 606 (-3.4A)
None
None
 0.91A 1xzxX-5c8sB:
undetectable		 1xzxX-5c8sB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 PHE A  98
ARG A 487
ASN A  95
 None
 0.91A 1xzxX-5ek8A:
undetectable		 1xzxX-5ek8A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 PHE z 136
ARG z 511
ASN z 410
 None
 0.85A 1xzxX-5gw5z:
undetectable		 1xzxX-5gw5z:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1u GERMACRADIEN-4-OL
SYNTHASE

(Streptomyces
citricolor) 		no annotation 3 PHE A 216
ARG A 240
ASN A 234
 None
 0.86A 1xzxX-5i1uA:
undetectable		 1xzxX-5i1uA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 PHE A1389
ARG A1422
ASN A 858
 None
 0.88A 1xzxX-5ip9A:
undetectable		 1xzxX-5ip9A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpv ASIALOGLYCOPROTEIN
RECEPTOR 1

(Homo sapiens) 		PF00059
(Lectin_C) 		3 PHE A 257
ARG A 270
ASN A 208
 None
CL  A 305 (-4.4A)
None
 0.94A 1xzxX-5jpvA:
undetectable		 1xzxX-5jpvA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly8 TAIL COMPONENT

(Lactobacillus
phage J-1) 		no annotation 3 PHE A  54
ARG A  99
ASN A 225
 None
 0.89A 1xzxX-5ly8A:
undetectable		 1xzxX-5ly8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		3 PHE A 311
ARG A 587
ASN A 353
 None
 0.63A 1xzxX-5n6uA:
undetectable		 1xzxX-5n6uA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE

(metagenome) 		no annotation 3 PHE A 203
ARG A  64
ASN A 198
 None
 0.87A 1xzxX-5nfqA:
undetectable		 1xzxX-5nfqA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 3 PHE A 274
ARG A 296
ASN A 414
 None
 0.87A 1xzxX-5ukhA:
undetectable		 1xzxX-5ukhA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		3 PHE B 316
ARG B  46
ASN B 247
 None
 0.76A 1xzxX-5w3jB:
undetectable		 1xzxX-5w3jB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT C

(Flavobacterium
johnsoniae) 		no annotation 3 PHE B 899
ARG C 136
ASN B 897
 None
 0.94A 1xzxX-6btmB:
undetectable		 1xzxX-6btmB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 3 PHE C 187
ARG C 228
ASN C 230
 None
 0.90A 1xzxX-6cajC:
undetectable		 1xzxX-6cajC:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 3 PHE A 771
ARG A 816
ASN A 787
 None
 0.67A 1xzxX-6fa5A:
undetectable		 1xzxX-6fa5A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fri ALKANAL
MONOOXYGENASE BETA
CHAIN

(Photobacterium
leiognathi) 		no annotation 3 PHE A  42
ARG A 195
ASN A  77
 None
 0.61A 1xzxX-6friA:
undetectable		 1xzxX-6friA:
13.62