SIMILAR PATTERNS OF AMINO ACIDS FOR 1XZX_X_T3X500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE A 402
ALA A 423
ILE A 278
MET A 391
PHE A 398
 None
 1.23A 1xzxX-1br2A:
0.0		 1xzxX-1br2A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN

(Cricetulus
griseus) 		PF00004
(AAA) 		5 ILE A 702
ALA A 703
LEU A 718
ILE A 678
PHE A 694
 None
 1.17A 1xzxX-1d2nA:
0.0		 1xzxX-1d2nA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm1 MYOGLOBIN

(Aplysia
limacina) 		PF00042
(Globin) 		5 ILE A 138
ILE A 137
ALA A 140
MET A  84
LEU A   2
 None
 1.21A 1xzxX-1dm1A:
undetectable		 1xzxX-1dm1A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8a S100A12

(Homo sapiens) 		PF01023
(S_100) 		5 ILE A  44
ILE A  79
ALA A  83
LEU A  40
ILE A  10
 None
 1.12A 1xzxX-1e8aA:
undetectable		 1xzxX-1e8aA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 ILE A  24
ALA A  25
ARG A  85
ILE A 367
HIS A 381
 None
 1.08A 1xzxX-1jxkA:
0.0		 1xzxX-1jxkA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgs DNA BINDING RESPONSE
REGULATOR D

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 ILE A 211
ILE A 212
ALA A 222
LEU A 134
LEU A 152
 None
 1.08A 1xzxX-1kgsA:
0.0		 1xzxX-1kgsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
CYTOCHROME B556(FDN)
SUBUNIT

(Escherichia
coli) 		PF01292
(Ni_hydr_CYTB) 		5 ILE C 163
ILE C 166
ALA C 165
MET C 116
LEU C  68
 CDL  C 812 ( 4.9A)
HEM  C 810 (-4.0A)
None
None
None
 1.26A 1xzxX-1kqfC:
0.8		 1xzxX-1kqfC:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 221
ILE A 222
ALA A 225
ARG A 228
MET A 256
MET A 259
LEU A 276
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
 None
IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 0.69A 1xzxX-1navA:
37.1		 1xzxX-1navA:
83.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ILE A 222
ALA A 225
MET A 259
LEU A 292
ILE A 377
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.25A 1xzxX-1navA:
37.1		 1xzxX-1navA:
83.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ort ORNITHINE
TRANSCARBAMOYLASE

(Pseudomonas
aeruginosa) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ILE A 324
ILE A 327
ALA A 326
ILE A 175
HIS A  15
 None
 1.03A 1xzxX-1ortA:
0.0		 1xzxX-1ortA:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 275
ILE A 276
ALA A 279
ARG A 282
MET A 310
MET A 313
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 None
G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.6A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.57A 1xzxX-1q4xA:
37.5		 1xzxX-1q4xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ILE A 275
ILE A 276
ALA A 279
ARG A 282
MET A 313
LEU A 341
ILE A 353
 None
G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.6A)
None
None
 1.34A 1xzxX-1q4xA:
37.5		 1xzxX-1q4xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 ILE A 146
ILE A 148
ALA A 216
LEU A 184
LEU A 161
 None
 1.14A 1xzxX-1rj6A:
0.0		 1xzxX-1rj6A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		5 ILE A 440
ILE A 443
ALA A 384
LEU A 423
ILE A 479
 None
 0.91A 1xzxX-1upxA:
undetectable		 1xzxX-1upxA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ILE A 358
ILE A 359
LEU A 409
ILE A 142
PHE A 402
 None
 1.02A 1xzxX-1x55A:
undetectable		 1xzxX-1x55A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 ILE A 181
ILE A 140
ALA A 177
LEU A 146
ILE A 132
 None
 1.06A 1xzxX-2a7sA:
undetectable		 1xzxX-2a7sA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 140
ILE A 139
ALA A 138
LEU A   9
ILE A 109
 None
None
None
FAD  A 480 (-4.1A)
None
 1.23A 1xzxX-2a8xA:
undetectable		 1xzxX-2a8xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 ILE A 325
ILE A 322
MET A 292
LEU A  47
HIS A  -1
 None
 1.18A 1xzxX-2afbA:
undetectable		 1xzxX-2afbA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		5 ILE A 429
ALA A 506
LEU A 504
LEU A 402
PHE A 427
 None
 1.25A 1xzxX-2btvA:
undetectable		 1xzxX-2btvA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dit HIV TAT SPECIFIC
FACTOR 1 VARIANT

(Homo sapiens) 		PF00076
(RRM_1) 		5 ILE A  19
ILE A  20
ALA A  96
LEU A  56
ILE A  53
 None
 1.23A 1xzxX-2ditA:
undetectable		 1xzxX-2ditA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36

(Mus musculus) 		PF11605
(Vps36_ESCRT-II) 		5 ILE A  48
ALA A  60
LEU A  40
LEU A 122
ILE A  82
 None
 1.19A 1xzxX-2dx5A:
undetectable		 1xzxX-2dx5A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekm HYPOTHETICAL PROTEIN
ST1511

(Sulfurisphaera
tokodaii) 		PF04008
(Adenosine_kin) 		5 ILE A  68
ILE A  47
ALA A  71
LEU A  67
LEU A  43
 None
 1.11A 1xzxX-2ekmA:
undetectable		 1xzxX-2ekmA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651

(Methanocaldococcus
jannaschii) 		PF01887
(SAM_adeno_trans) 		5 ALA A  70
LEU A  67
ILE A  55
HIS A  53
MET A  31
 None
 1.24A 1xzxX-2f4nA:
undetectable		 1xzxX-2f4nA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651

(Methanocaldococcus
jannaschii) 		PF01887
(SAM_adeno_trans) 		5 ILE A  71
LEU A  67
ILE A  55
HIS A  53
MET A  31
 None
 1.13A 1xzxX-2f4nA:
undetectable		 1xzxX-2f4nA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9h EXTRACELLULAR
ENTEROTOXIN TYPE I

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 ILE D 139
LEU D 129
LEU D  99
ILE D 108
PHE D 161
 None
 1.09A 1xzxX-2g9hD:
undetectable		 1xzxX-2g9hD:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		5 ILE A 171
ILE A  61
ALA A  64
MET A 144
LEU A 159
 None
 1.21A 1xzxX-2gmlA:
undetectable		 1xzxX-2gmlA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqb CONSERVED
HYPOTHETICAL PROTEIN

(Rhodopseudomonas
palustris) 		PF12200
(DUF3597) 		5 ILE A   7
ILE A  11
LEU A  73
ILE A 128
PHE A  12
 None
 1.25A 1xzxX-2gqbA:
undetectable		 1xzxX-2gqbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 ALA A 367
MET A 342
LEU A 599
ILE A 443
HIS A 337
 None
None
D12  A1703 (-4.2A)
None
None
 1.06A 1xzxX-2h4tA:
undetectable		 1xzxX-2h4tA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrb ORF 1 PROTEIN

(Mus musculus) 		PF17490
(Tnp_22_dsRBD) 		5 ILE A 352
ALA A 348
LEU A 343
LEU A 307
ILE A 324
 None
 1.03A 1xzxX-2jrbA:
undetectable		 1xzxX-2jrbA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzx POLY(RC)-BINDING
PROTEIN 2

(Homo sapiens) 		PF00013
(KH_1) 		5 ILE A 156
ILE A 155
LEU A  79
ILE A  83
MET A  20
 None
 1.15A 1xzxX-2jzxA:
undetectable		 1xzxX-2jzxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odh R.BCNI

(Brevibacillus
centrosporus) 		PF15515
(MvaI_BcnI) 		5 ILE A 134
ALA A 128
LEU A 148
LEU A 230
ILE A 185
 None
None
ACT  A 239 (-4.5A)
None
None
 1.16A 1xzxX-2odhA:
undetectable		 1xzxX-2odhA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A  97
ILE A 100
ALA A  99
ILE A 126
PHE A 104
 None
 1.17A 1xzxX-2oi2A:
undetectable		 1xzxX-2oi2A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwq UBIQUITIN
CONJUGATING ENZYME

(Plasmodium
yoelii) 		PF00179
(UQ_con) 		5 ILE A  86
LEU A  91
LEU A 105
ILE A 101
PHE A  70
 None
 1.18A 1xzxX-2pwqA:
undetectable		 1xzxX-2pwqA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 ILE A   7
ILE A   8
ALA A  33
LEU A  86
HIS A  55
 None
 1.04A 1xzxX-2qk4A:
undetectable		 1xzxX-2qk4A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
halodurans) 		PF00268
(Ribonuc_red_sm) 		5 ILE A 267
ILE A 268
ALA A  76
ILE A 212
MET A 309
 PG4  A 346 ( 4.8A)
None
None
None
None
 1.25A 1xzxX-2rccA:
3.1		 1xzxX-2rccA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		5 ILE A 204
ILE A 209
ARG A 205
ILE A  89
PHE A 107
 None
 1.22A 1xzxX-2vsaA:
undetectable		 1xzxX-2vsaA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ILE A 353
ARG A 351
LEU A 374
ILE A 400
PHE A 239
 None
 1.25A 1xzxX-2y3sA:
undetectable		 1xzxX-2y3sA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyv TYROSINE-ESTER
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		5 ILE X 104
ARG X  78
LEU X  58
LEU X 208
ILE X 204
 None
 1.20A 1xzxX-2zyvX:
undetectable		 1xzxX-2zyvX:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afb PUTATIVE CHITINASE

(Pyrococcus
furiosus) 		no annotation 5 ILE A 484
ILE A 485
ALA A 486
MET A 424
LEU A 432
 None
 0.99A 1xzxX-3afbA:
undetectable		 1xzxX-3afbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ILE A 715
ALA A 719
MET A 760
LEU A 756
LEU A 629
 None
 1.09A 1xzxX-3b2rA:
undetectable		 1xzxX-3b2rA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ALA A1081
ARG A1085
LEU A1107
ILE A1262
PHE A1092
 None
 1.26A 1xzxX-3cmtA:
undetectable		 1xzxX-3cmtA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE

(Thiobacillus
denitrificans) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A 446
ILE A 444
MET A 396
LEU A 389
LEU A 543
 None
 1.25A 1xzxX-3cr8A:
undetectable		 1xzxX-3cr8A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi1 NA(+)/H(+)
ANTIPORTER NHAA

(Escherichia
coli) 		PF06965
(Na_H_antiport_1) 		5 ILE A 169
ILE A 168
ALA A 167
MET A 341
ILE A 134
 None
 1.13A 1xzxX-3fi1A:
undetectable		 1xzxX-3fi1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h41 NLP/P60 FAMILY
PROTEIN

(Bacillus cereus) 		PF00877
(NLPC_P60) 		5 ILE A 215
ILE A 302
LEU A 214
LEU A 277
ILE A 253
 PG4  A   2 (-3.7A)
None
None
None
None
 1.23A 1xzxX-3h41A:
undetectable		 1xzxX-3h41A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  90
ALA A  51
LEU A 112
LEU A  34
ILE A  73
 None
 1.07A 1xzxX-3hveA:
undetectable		 1xzxX-3hveA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioq CMS1MS2

(Vasconcellea
cundinamarcensis) 		PF00112
(Peptidase_C1) 		5 ILE A 171
ILE A 173
ALA A 163
ILE A 157
HIS A 159
 None
None
None
E64  A 301 ( 4.3A)
E64  A 301 (-3.8A)
 1.23A 1xzxX-3ioqA:
undetectable		 1xzxX-3ioqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuv UNCHARACTERIZED TETR
FAMILY PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 ILE A  13
ALA A  16
ARG A  19
LEU A  42
HIS A  31
 None
 1.21A 1xzxX-3iuvA:
undetectable		 1xzxX-3iuvA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 5 ILE B 979
ILE B 820
ALA B 982
LEU B 967
PHE B 819
 None
 0.99A 1xzxX-3iz3B:
undetectable		 1xzxX-3iz3B:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 5 ILE B 979
ILE B 820
ALA B 982
LEU B 974
PHE B 819
 None
 1.12A 1xzxX-3iz3B:
undetectable		 1xzxX-3iz3B:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		5 ILE A 346
ILE A 326
ALA A 327
ILE A 365
PHE A 271
 None
 1.23A 1xzxX-3k9dA:
undetectable		 1xzxX-3k9dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyl TELOMERASE REVERSE
TRANSCRIPTASE

(Tribolium
castaneum) 		PF00078
(RVT_1)
PF12009
(Telomerase_RBD) 		5 ILE A  55
ILE A  56
ALA A  30
LEU A 123
PHE A  61
 None
 1.11A 1xzxX-3kylA:
undetectable		 1xzxX-3kylA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN

(Sinorhizobium
meliloti) 		PF01557
(FAA_hydrolase) 		5 ILE A 260
ILE A 259
ALA A 143
MET A 166
LEU A  39
 None
 1.21A 1xzxX-3lzkA:
undetectable		 1xzxX-3lzkA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n11 CHITINASE A

(Bacillus cereus) 		PF00704
(Glyco_hydro_18) 		5 ILE A 307
LEU A 303
LEU A 281
ILE A 294
HIS A 226
 None
 1.04A 1xzxX-3n11A:
undetectable		 1xzxX-3n11A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2r RIBONUCLEASE III

(Campylobacter
jejuni) 		PF14622
(Ribonucleas_3_3) 		5 ILE B 118
ILE B 122
ALA B 121
LEU B  21
PHE B 130
 None
 1.04A 1xzxX-3o2rB:
undetectable		 1xzxX-3o2rB:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		5 ILE A  27
ILE A  28
ALA A  31
ILE A 286
PHE A  62
 None
 1.18A 1xzxX-3pt1A:
undetectable		 1xzxX-3pt1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		5 ILE A 108
ILE A 107
ALA A 106
ARG A 109
LEU A 141
 None
 1.09A 1xzxX-3qanA:
undetectable		 1xzxX-3qanA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz0 FACTOR H BINDING
PROTEIN

(Treponema
denticola) 		no annotation 5 ILE A  97
ILE A  74
MET A  59
LEU A  42
ILE A  83
 None
 1.24A 1xzxX-3qz0A:
undetectable		 1xzxX-3qz0A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u24 PUTATIVE LIPOPROTEIN

(Shewanella
oneidensis) 		PF05960
(DUF885) 		5 ILE A 229
ALA A 233
LEU A  73
ILE A  75
PHE A 202
 None
None
EDO  A 600 (-4.8A)
CA  A 607 ( 4.8A)
None
 1.01A 1xzxX-3u24A:
undetectable		 1xzxX-3u24A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		5 ILE A 341
ALA A 346
LEU A 293
ILE A 296
HIS A 278
 None
None
BCT  A 435 (-3.9A)
None
None
 1.22A 1xzxX-3v7pA:
undetectable		 1xzxX-3v7pA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		5 ILE A 267
ARG A 266
LEU A 126
LEU A 151
ILE A 117
 None
 1.26A 1xzxX-3vqrA:
undetectable		 1xzxX-3vqrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		5 ILE A  78
ILE A  77
ALA A  81
LEU A 209
ILE A 211
 GOL  A 403 ( 4.7A)
None
None
None
None
 1.08A 1xzxX-4eb5A:
undetectable		 1xzxX-4eb5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fyu THIOREDOXIN

(Wuchereria
bancrofti) 		PF13905
(Thioredoxin_8) 		5 ILE A   8
ALA A   6
LEU A  24
LEU A  32
ILE A 114
 None
 1.12A 1xzxX-4fyuA:
undetectable		 1xzxX-4fyuA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ija XYLR PROTEIN

(Staphylococcus
aureus) 		PF00480
(ROK)
PF01047
(MarR) 		5 ILE A 311
ILE A 313
LEU A 302
ILE A 247
PHE A 318
 None
None
GOL  A 502 (-4.6A)
GOL  A 502 ( 4.4A)
None
 1.16A 1xzxX-4ijaA:
undetectable		 1xzxX-4ijaA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE

(Pseudoalteromonas
atlantica) 		PF00348
(polyprenyl_synt) 		5 ILE A  73
ILE A  72
ALA A  71
LEU A 185
ILE A  61
 None
 1.05A 1xzxX-4jxyA:
undetectable		 1xzxX-4jxyA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf6 GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF08718
(GLTP) 		5 ILE A 194
MET A 186
LEU A 191
LEU A 125
PHE A  42
 None
 1.21A 1xzxX-4kf6A:
undetectable		 1xzxX-4kf6A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 1.15A 1xzxX-4m38A:
undetectable		 1xzxX-4m38A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 ILE A 466
ILE A 465
ALA A 414
LEU A 427
ILE A 498
 None
 1.18A 1xzxX-4phcA:
undetectable		 1xzxX-4phcA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE

(Lactobacillus
jensenii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 229
ILE A 253
ALA A 254
LEU A 117
PHE A 221
 None
 1.24A 1xzxX-4prkA:
undetectable		 1xzxX-4prkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE

(Lactobacillus
jensenii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 253
ALA A 254
LEU A 117
LEU A 258
PHE A 221
 None
 1.21A 1xzxX-4prkA:
undetectable		 1xzxX-4prkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 ILE A 423
ILE A 424
ALA A 427
LEU A 333
ILE A 295
 None
 1.22A 1xzxX-4q6rA:
undetectable		 1xzxX-4q6rA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		5 ILE B 282
MET B 259
LEU B 363
LEU B 441
ILE B 414
 None
 1.19A 1xzxX-4tx2B:
undetectable		 1xzxX-4tx2B:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0p LIPOYL SYNTHASE 2

(Thermosynechococcus
elongatus) 		PF04055
(Radical_SAM) 		5 ILE B 158
ALA B 161
MET B 123
LEU B  58
ILE B  89
 None
 1.25A 1xzxX-4u0pB:
undetectable		 1xzxX-4u0pB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN

(Homo sapiens) 		PF10421
(OAS1_C) 		5 ILE A 108
LEU A 126
LEU A 118
ILE A 140
PHE A  49
 None
 1.16A 1xzxX-4xq7A:
undetectable		 1xzxX-4xq7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135

(Acanthamoeba
polyphaga
mimivirus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A 267
ILE A 266
ALA A 273
LEU A  36
ILE A  34
 None
 1.16A 1xzxX-4z26A:
undetectable		 1xzxX-4z26A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn7 MALTODEXTRIN
GLUCOSIDASE

(Escherichia
coli) 		PF00128
(Alpha-amylase) 		5 ILE A 319
ILE A 312
LEU A 335
ILE A 370
HIS A 353
 None
 1.07A 1xzxX-5bn7A:
undetectable		 1xzxX-5bn7A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ILE A  93
ARG A 113
LEU A  77
ILE A  23
PHE A  88
 None
 1.12A 1xzxX-5ce6A:
undetectable		 1xzxX-5ce6A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee0 OBG-LIKE ATPASE 1

(Oryza sativa) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 ILE A  95
ILE A  29
LEU A  90
ILE A 302
PHE A  40
 None
 1.24A 1xzxX-5ee0A:
undetectable		 1xzxX-5ee0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		5 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.94A 1xzxX-5egeA:
undetectable		 1xzxX-5egeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 1.02A 1xzxX-5ekuA:
undetectable		 1xzxX-5ekuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guh PIWI

(Bombyx mori) 		PF02170
(PAZ)
PF02171
(Piwi) 		5 ILE A 737
ILE A 776
ALA A 774
LEU A 853
ILE A 659
 None
 1.14A 1xzxX-5guhA:
undetectable		 1xzxX-5guhA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF01326
(PPDK_N) 		5 ILE A  92
ALA A  47
MET A 100
LEU A 146
ILE A 182
 None
 1.17A 1xzxX-5hv6A:
undetectable		 1xzxX-5hv6A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 ILE A 291
ILE A 292
ALA A 255
ILE A 433
PHE A 390
 None
 1.21A 1xzxX-5j6bA:
undetectable		 1xzxX-5j6bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxb DISKS LARGE HOMOLOG
4,SYNGAP

(Homo sapiens;
Mus musculus) 		PF00595
(PDZ) 		5 ILE A 311
ILE A 313
ALA A 344
LEU A 376
ILE A 324
 None
 1.26A 1xzxX-5jxbA:
undetectable		 1xzxX-5jxbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 ILE A 536
ILE A 535
ALA A 538
ARG A 541
PHE A 352
 None
 1.24A 1xzxX-5k3jA:
undetectable		 1xzxX-5k3jA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ILE A 204
ILE A 208
LEU A 227
ILE A 169
PHE A 212
 None
 1.10A 1xzxX-5kc8A:
undetectable		 1xzxX-5kc8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ILE A 261
ILE A 231
LEU A 185
ILE A 178
PHE A 168
 None
 1.15A 1xzxX-5kc8A:
undetectable		 1xzxX-5kc8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		5 ILE A 747
ILE A 717
LEU A 671
ILE A 664
PHE A 654
 None
 1.14A 1xzxX-5kcaA:
undetectable		 1xzxX-5kcaA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2e GLUTAMATE RECEPTOR
IONOTROPIC,
DELTA-2,GLUTAMATE
RECEPTOR IONOTROPIC,
DELTA-2

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 ILE A 261
ILE A 231
LEU A 185
ILE A 178
PHE A 168
 None
 1.22A 1xzxX-5l2eA:
undetectable		 1xzxX-5l2eA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH

(Staphylococcus
capitis) 		PF01566
(Nramp) 		5 ILE A 372
ILE A 369
LEU A 371
LEU A 384
ILE A 129
 None
 1.21A 1xzxX-5m95A:
undetectable		 1xzxX-5m95A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Desulfovibrio
vulgaris) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A  38
ILE A  39
ALA A  42
LEU A  55
ILE A  89
 None
 1.24A 1xzxX-5tx7A:
undetectable		 1xzxX-5tx7A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v77 UNCHARACTERIZED
PROTEIN

(Neisseria
gonorrhoeae) 		no annotation 5 ILE A  98
ILE A  93
LEU A  11
ILE A  69
PHE A  47
 None
 1.07A 1xzxX-5v77A:
undetectable		 1xzxX-5v77A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 ILE A 170
ALA A 137
LEU A 233
ILE A 235
PHE A 174
 None
 1.22A 1xzxX-5vemA:
undetectable		 1xzxX-5vemA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26

(Saccharomyces
cerevisiae) 		no annotation 5 ILE M 330
ILE M 333
ALA M 334
ILE M 494
PHE M 365
 None
 1.22A 1xzxX-5vvrM:
undetectable		 1xzxX-5vvrM:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 5 ILE A 466
ILE A 465
ALA A 414
LEU A 427
ILE A 498
 None
 1.18A 1xzxX-5w6mA:
undetectable		 1xzxX-5w6mA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 5 ILE A 693
ALA A 689
LEU A 665
LEU A 595
ILE A 591
 None
 1.23A 1xzxX-5wblA:
undetectable		 1xzxX-5wblA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		5 ILE O1180
ILE O1108
MET O1119
LEU O1211
LEU O1096
 None
 1.21A 1xzxX-5x0yO:
undetectable		 1xzxX-5x0yO:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9j PRHC

(Penicillium
brasilianum) 		no annotation 5 ILE A  20
ILE A  21
LEU A  32
LEU A 112
PHE A  72
 None
 1.14A 1xzxX-5x9jA:
undetectable		 1xzxX-5x9jA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B 183
ILE B 158
LEU B 150
LEU B 140
ILE B 107
 None
 1.21A 1xzxX-5y59B:
undetectable		 1xzxX-5y59B:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yww NUCLEOTIDE BINDING
PROTEIN PINC

(Sulfolobus
islandicus) 		no annotation 5 ILE A 252
ILE A 253
ALA A 254
LEU A 240
PHE A 264
 None
 1.20A 1xzxX-5ywwA:
undetectable		 1xzxX-5ywwA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gww PEROXIREDOXIN

(Sulfolobus
islandicus) 		no annotation 5 ILE A 153
ILE A 157
ALA A 156
ARG A 155
ILE A   9
 None
 1.11A 1xzxX-6gwwA:
undetectable		 1xzxX-6gwwA:
17.69