SIMILAR PATTERNS OF AMINO ACIDS FOR 1XZX_X_T3X500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ILE A 402
ALA A 423
ILE A 278
MET A 391
PHE A 398
 None
 1.23A 1xzxX-1br2A:
0.0		 1xzxX-1br2A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2n N-ETHYLMALEIMIDE-SEN
SITIVE FUSION
PROTEIN

(Cricetulus
griseus) 		PF00004
(AAA) 		5 ILE A 702
ALA A 703
LEU A 718
ILE A 678
PHE A 694
 None
 1.17A 1xzxX-1d2nA:
0.0		 1xzxX-1d2nA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm1 MYOGLOBIN

(Aplysia
limacina) 		PF00042
(Globin) 		5 ILE A 138
ILE A 137
ALA A 140
MET A  84
LEU A   2
 None
 1.21A 1xzxX-1dm1A:
undetectable		 1xzxX-1dm1A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8a S100A12

(Homo sapiens) 		PF01023
(S_100) 		5 ILE A  44
ILE A  79
ALA A  83
LEU A  40
ILE A  10
 None
 1.12A 1xzxX-1e8aA:
undetectable		 1xzxX-1e8aA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 ILE A  24
ALA A  25
ARG A  85
ILE A 367
HIS A 381
 None
 1.08A 1xzxX-1jxkA:
0.0		 1xzxX-1jxkA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgs DNA BINDING RESPONSE
REGULATOR D

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 ILE A 211
ILE A 212
ALA A 222
LEU A 134
LEU A 152
 None
 1.08A 1xzxX-1kgsA:
0.0		 1xzxX-1kgsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
CYTOCHROME B556(FDN)
SUBUNIT

(Escherichia
coli) 		PF01292
(Ni_hydr_CYTB) 		5 ILE C 163
ILE C 166
ALA C 165
MET C 116
LEU C  68
 CDL  C 812 ( 4.9A)
HEM  C 810 (-4.0A)
None
None
None
 1.26A 1xzxX-1kqfC:
0.8		 1xzxX-1kqfC:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 221
ILE A 222
ALA A 225
ARG A 228
MET A 256
MET A 259
LEU A 276
LEU A 292
ILE A 299
HIS A 381
MET A 388
PHE A 401
 None
IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.2A)
IH5  A 600 (-3.6A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.0A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
IH5  A 600 (-3.7A)
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 0.69A 1xzxX-1navA:
37.1		 1xzxX-1navA:
83.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ILE A 222
ALA A 225
MET A 259
LEU A 292
ILE A 377
MET A 388
PHE A 401
 IH5  A 600 (-4.3A)
IH5  A 600 (-3.5A)
IH5  A 600 (-4.7A)
IH5  A 600 (-4.7A)
None
IH5  A 600 (-3.8A)
IH5  A 600 (-4.4A)
 1.25A 1xzxX-1navA:
37.1		 1xzxX-1navA:
83.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ort ORNITHINE
TRANSCARBAMOYLASE

(Pseudomonas
aeruginosa) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ILE A 324
ILE A 327
ALA A 326
ILE A 175
HIS A  15
 None
 1.03A 1xzxX-1ortA:
0.0		 1xzxX-1ortA:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 ILE A 275
ILE A 276
ALA A 279
ARG A 282
MET A 310
MET A 313
LEU A 330
LEU A 346
ILE A 353
HIS A 435
PHE A 455
 None
G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 3.8A)
G24  A 462 ( 4.6A)
G24  A 462 ( 3.9A)
G24  A 462 (-4.0A)
None
G24  A 462 (-3.9A)
G24  A 462 (-3.8A)
 0.57A 1xzxX-1q4xA:
37.5		 1xzxX-1q4xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ILE A 275
ILE A 276
ALA A 279
ARG A 282
MET A 313
LEU A 341
ILE A 353
 None
G24  A 462 ( 4.3A)
G24  A 462 (-3.5A)
G24  A 462 ( 3.9A)
G24  A 462 ( 4.6A)
None
None
 1.34A 1xzxX-1q4xA:
37.5		 1xzxX-1q4xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 ILE A 146
ILE A 148
ALA A 216
LEU A 184
LEU A 161
 None
 1.14A 1xzxX-1rj6A:
0.0		 1xzxX-1rj6A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		5 ILE A 440
ILE A 443
ALA A 384
LEU A 423
ILE A 479
 None
 0.91A 1xzxX-1upxA:
undetectable		 1xzxX-1upxA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ILE A 358
ILE A 359
LEU A 409
ILE A 142
PHE A 402
 None
 1.02A 1xzxX-1x55A:
undetectable		 1xzxX-1x55A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 ILE A 181
ILE A 140
ALA A 177
LEU A 146
ILE A 132
 None
 1.06A 1xzxX-2a7sA:
undetectable		 1xzxX-2a7sA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A 140
ILE A 139
ALA A 138
LEU A   9
ILE A 109
 None
None
None
FAD  A 480 (-4.1A)
None
 1.23A 1xzxX-2a8xA:
undetectable		 1xzxX-2a8xA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 ILE A 325
ILE A 322
MET A 292
LEU A  47
HIS A  -1
 None
 1.18A 1xzxX-2afbA:
undetectable		 1xzxX-2afbA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		5 ILE A 429
ALA A 506
LEU A 504
LEU A 402
PHE A 427
 None
 1.25A 1xzxX-2btvA:
undetectable		 1xzxX-2btvA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dit HIV TAT SPECIFIC
FACTOR 1 VARIANT

(Homo sapiens) 		PF00076
(RRM_1) 		5 ILE A  19
ILE A  20
ALA A  96
LEU A  56
ILE A  53
 None
 1.23A 1xzxX-2ditA:
undetectable		 1xzxX-2ditA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36

(Mus musculus) 		PF11605
(Vps36_ESCRT-II) 		5 ILE A  48
ALA A  60
LEU A  40
LEU A 122
ILE A  82
 None
 1.19A 1xzxX-2dx5A:
undetectable		 1xzxX-2dx5A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekm HYPOTHETICAL PROTEIN
ST1511

(Sulfurisphaera
tokodaii) 		PF04008
(Adenosine_kin) 		5 ILE A  68
ILE A  47
ALA A  71
LEU A  67
LEU A  43
 None
 1.11A 1xzxX-2ekmA:
undetectable		 1xzxX-2ekmA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651

(Methanocaldococcus
jannaschii) 		PF01887
(SAM_adeno_trans) 		5 ALA A  70
LEU A  67
ILE A  55
HIS A  53
MET A  31
 None
 1.24A 1xzxX-2f4nA:
undetectable		 1xzxX-2f4nA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4n HYPOTHETICAL PROTEIN
MJ1651

(Methanocaldococcus
jannaschii) 		PF01887
(SAM_adeno_trans) 		5 ILE A  71
LEU A  67
ILE A  55
HIS A  53
MET A  31
 None
 1.13A 1xzxX-2f4nA:
undetectable		 1xzxX-2f4nA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9h EXTRACELLULAR
ENTEROTOXIN TYPE I

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		5 ILE D 139
LEU D 129
LEU D  99
ILE D 108
PHE D 161
 None
 1.09A 1xzxX-2g9hD:
undetectable		 1xzxX-2g9hD:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE F

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		5 ILE A 171
ILE A  61
ALA A  64
MET A 144
LEU A 159
 None
 1.21A 1xzxX-2gmlA:
undetectable		 1xzxX-2gmlA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqb CONSERVED
HYPOTHETICAL PROTEIN

(Rhodopseudomonas
palustris) 		PF12200
(DUF3597) 		5 ILE A   7
ILE A  11
LEU A  73
ILE A 128
PHE A  12
 None
 1.25A 1xzxX-2gqbA:
undetectable		 1xzxX-2gqbA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 ALA A 367
MET A 342
LEU A 599
ILE A 443
HIS A 337
 None
None
D12  A1703 (-4.2A)
None
None
 1.06A 1xzxX-2h4tA:
undetectable		 1xzxX-2h4tA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrb ORF 1 PROTEIN

(Mus musculus) 		PF17490
(Tnp_22_dsRBD) 		5 ILE A 352
ALA A 348
LEU A 343
LEU A 307
ILE A 324
 None
 1.03A 1xzxX-2jrbA:
undetectable		 1xzxX-2jrbA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzx POLY(RC)-BINDING
PROTEIN 2

(Homo sapiens) 		PF00013
(KH_1) 		5 ILE A 156
ILE A 155
LEU A  79
ILE A  83
MET A  20
 None
 1.15A 1xzxX-2jzxA:
undetectable		 1xzxX-2jzxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odh R.BCNI

(Brevibacillus
centrosporus) 		PF15515
(MvaI_BcnI) 		5 ILE A 134
ALA A 128
LEU A 148
LEU A 230
ILE A 185
 None
None
ACT  A 239 (-4.5A)
None
None
 1.16A 1xzxX-2odhA:
undetectable		 1xzxX-2odhA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A  97
ILE A 100
ALA A  99
ILE A 126
PHE A 104
 None
 1.17A 1xzxX-2oi2A:
undetectable		 1xzxX-2oi2A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwq UBIQUITIN
CONJUGATING ENZYME

(Plasmodium
yoelii) 		PF00179
(UQ_con) 		5 ILE A  86
LEU A  91
LEU A 105
ILE A 101
PHE A  70
 None
 1.18A 1xzxX-2pwqA:
undetectable		 1xzxX-2pwqA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 ILE A   7
ILE A   8
ALA A  33
LEU A  86
HIS A  55
 None
 1.04A 1xzxX-2qk4A:
undetectable		 1xzxX-2qk4A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
halodurans) 		PF00268
(Ribonuc_red_sm) 		5 ILE A 267
ILE A 268
ALA A  76
ILE A 212
MET A 309
 PG4  A 346 ( 4.8A)
None
None
None
None
 1.25A 1xzxX-2rccA:
3.1		 1xzxX-2rccA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		5 ILE A 204
ILE A 209
ARG A 205
ILE A  89
PHE A 107
 None
 1.22A 1xzxX-2vsaA:
undetectable		 1xzxX-2vsaA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ILE A 353
ARG A 351
LEU A 374
ILE A 400
PHE A 239
 None
 1.25A 1xzxX-2y3sA:
undetectable		 1xzxX-2y3sA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyv TYROSINE-ESTER
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		5 ILE X 104
ARG X  78
LEU X  58
LEU X 208
ILE X 204
 None
 1.20A 1xzxX-2zyvX:
undetectable		 1xzxX-2zyvX:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afb PUTATIVE CHITINASE

(Pyrococcus
furiosus) 		no annotation 5 ILE A 484
ILE A 485
ALA A 486
MET A 424
LEU A 432
 None
 0.99A 1xzxX-3afbA:
undetectable		 1xzxX-3afbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ILE A 715
ALA A 719
MET A 760
LEU A 756
LEU A 629
 None
 1.09A 1xzxX-3b2rA:
undetectable		 1xzxX-3b2rA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ALA A1081
ARG A1085
LEU A1107
ILE A1262
PHE A1092
 None
 1.26A 1xzxX-3cmtA:
undetectable		 1xzxX-3cmtA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE

(Thiobacillus
denitrificans) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A 446
ILE A 444
MET A 396
LEU A 389
LEU A 543
 None
 1.25A 1xzxX-3cr8A:
undetectable		 1xzxX-3cr8A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi1 NA(+)/H(+)
ANTIPORTER NHAA

(Escherichia
coli) 		PF06965
(Na_H_antiport_1) 		5 ILE A 169
ILE A 168
ALA A 167
MET A 341
ILE A 134
 None
 1.13A 1xzxX-3fi1A:
undetectable		 1xzxX-3fi1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h41 NLP/P60 FAMILY
PROTEIN

(Bacillus cereus) 		PF00877
(NLPC_P60) 		5 ILE A 215
ILE A 302
LEU A 214
LEU A 277
ILE A 253
 PG4  A   2 (-3.7A)
None
None
None
None
 1.23A 1xzxX-3h41A:
undetectable		 1xzxX-3h41A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  90
ALA A  51
LEU A 112
LEU A  34
ILE A  73
 None
 1.07A 1xzxX-3hveA:
undetectable		 1xzxX-3hveA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioq CMS1MS2

(Vasconcellea
cundinamarcensis) 		PF00112
(Peptidase_C1) 		5 ILE A 171
ILE A 173
ALA A 163
ILE A 157
HIS A 159
 None
None
None
E64  A 301 ( 4.3A)
E64  A 301 (-3.8A)
 1.23A 1xzxX-3ioqA:
undetectable		 1xzxX-3ioqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuv UNCHARACTERIZED TETR
FAMILY PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 ILE A  13
ALA A  16
ARG A  19
LEU A  42
HIS A  31
 None
 1.21A 1xzxX-3iuvA:
undetectable		 1xzxX-3iuvA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 5 ILE B 979
ILE B 820
ALA B 982
LEU B 967
PHE B 819
 None
 0.99A 1xzxX-3iz3B:
undetectable		 1xzxX-3iz3B:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 5 ILE B 979
ILE B 820
ALA B 982
LEU B 974
PHE B 819
 None
 1.12A 1xzxX-3iz3B:
undetectable		 1xzxX-3iz3B:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		5 ILE A 346
ILE A 326
ALA A 327
ILE A 365
PHE A 271
 None
 1.23A 1xzxX-3k9dA:
undetectable		 1xzxX-3k9dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyl TELOMERASE REVERSE
TRANSCRIPTASE

(Tribolium
castaneum) 		PF00078
(RVT_1)
PF12009
(Telomerase_RBD) 		5 ILE A  55
ILE A  56
ALA A  30
LEU A 123
PHE A  61
 None
 1.11A 1xzxX-3kylA:
undetectable		 1xzxX-3kylA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzk FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN

(Sinorhizobium
meliloti) 		PF01557
(FAA_hydrolase) 		5 ILE A 260
ILE A 259
ALA A 143
MET A 166
LEU A  39
 None
 1.21A 1xzxX-3lzkA:
undetectable		 1xzxX-3lzkA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n11 CHITINASE A

(Bacillus cereus) 		PF00704
(Glyco_hydro_18) 		5 ILE A 307
LEU A 303
LEU A 281
ILE A 294
HIS A 226
 None
 1.04A 1xzxX-3n11A:
undetectable		 1xzxX-3n11A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2r RIBONUCLEASE III

(Campylobacter
jejuni) 		PF14622
(Ribonucleas_3_3) 		5 ILE B 118
ILE B 122
ALA B 121
LEU B  21
PHE B 130
 None
 1.04A 1xzxX-3o2rB:
undetectable		 1xzxX-3o2rB:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		5 ILE A  27
ILE A  28
ALA A  31
ILE A 286
PHE A  62
 None
 1.18A 1xzxX-3pt1A:
undetectable		 1xzxX-3pt1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qan 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
1

(Bacillus
halodurans) 		PF00171
(Aldedh) 		5 ILE A 108
ILE A 107
ALA A 106
ARG A 109
LEU A 141
 None
 1.09A 1xzxX-3qanA:
undetectable		 1xzxX-3qanA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz0 FACTOR H BINDING
PROTEIN

(Treponema
denticola) 		no annotation 5 ILE A  97
ILE A  74
MET A  59
LEU A  42
ILE A  83
 None
 1.24A 1xzxX-3qz0A:
undetectable		 1xzxX-3qz0A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u24 PUTATIVE LIPOPROTEIN

(Shewanella
oneidensis) 		PF05960
(DUF885) 		5 ILE A 229
ALA A 233
LEU A  73
ILE A  75
PHE A 202
 None
None
EDO  A 600 (-4.8A)
CA  A 607 ( 4.8A)
None
 1.01A 1xzxX-3u24A:
undetectable		 1xzxX-3u24A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		5 ILE A 341
ALA A 346
LEU A 293
ILE A 296
HIS A 278
 None
None
BCT  A 435 (-3.9A)
None
None
 1.22A 1xzxX-3v7pA:
undetectable		 1xzxX-3v7pA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		5 ILE A 267
ARG A 266
LEU A 126
LEU A 151
ILE A 117
 None
 1.26A 1xzxX-3vqrA:
undetectable		 1xzxX-3vqrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		5 ILE A  78
ILE A  77
ALA A  81
LEU A 209
ILE A 211
 GOL  A 403 ( 4.7A)
None
None
None
None
 1.08A 1xzxX-4eb5A:
undetectable		 1xzxX-4eb5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fyu THIOREDOXIN

(Wuchereria
bancrofti) 		PF13905
(Thioredoxin_8) 		5 ILE A   8
ALA A   6
LEU A  24
LEU A  32
ILE A 114
 None
 1.12A 1xzxX-4fyuA:
undetectable		 1xzxX-4fyuA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ija XYLR PROTEIN

(Staphylococcus
aureus) 		PF00480
(ROK)
PF01047
(MarR) 		5 ILE A 311
ILE A 313
LEU A 302
ILE A 247
PHE A 318
 None
None
GOL  A 502 (-4.6A)
GOL  A 502 ( 4.4A)
None
 1.16A 1xzxX-4ijaA:
undetectable		 1xzxX-4ijaA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE

(Pseudoalteromonas
atlantica) 		PF00348
(polyprenyl_synt) 		5 ILE A  73
ILE A  72
ALA A  71
LEU A 185
ILE A  61
 None
 1.05A 1xzxX-4jxyA:
undetectable		 1xzxX-4jxyA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf6 GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF08718
(GLTP) 		5 ILE A 194
MET A 186
LEU A 191
LEU A 125
PHE A  42
 None
 1.21A 1xzxX-4kf6A:
undetectable		 1xzxX-4kf6A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 1.15A 1xzxX-4m38A:
undetectable		 1xzxX-4m38A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 ILE A 466
ILE A 465
ALA A 414
LEU A 427
ILE A 498
 None
 1.18A 1xzxX-4phcA:
undetectable		 1xzxX-4phcA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE

(Lactobacillus
jensenii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 229
ILE A 253
ALA A 254
LEU A 117
PHE A 221
 None
 1.24A 1xzxX-4prkA:
undetectable		 1xzxX-4prkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4prk 4-PHOSPHOERYTHRONATE
DEHYDROGENASE

(Lactobacillus
jensenii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 253
ALA A 254
LEU A 117
LEU A 258
PHE A 221
 None
 1.21A 1xzxX-4prkA:
undetectable		 1xzxX-4prkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 ILE A 423
ILE A 424
ALA A 427
LEU A 333
ILE A 295
 None
 1.22A 1xzxX-4q6rA:
undetectable		 1xzxX-4q6rA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		5 ILE B 282
MET B 259
LEU B 363
LEU B 441
ILE B 414
 None
 1.19A 1xzxX-4tx2B:
undetectable		 1xzxX-4tx2B:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0p LIPOYL SYNTHASE 2

(Thermosynechococcus
elongatus) 		PF04055
(Radical_SAM) 		5 ILE B 158
ALA B 161
MET B 123
LEU B  58
ILE B  89
 None
 1.25A 1xzxX-4u0pB:
undetectable		 1xzxX-4u0pB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN

(Homo sapiens) 		PF10421
(OAS1_C) 		5 ILE A 108
LEU A 126
LEU A 118
ILE A 140
PHE A  49
 None
 1.16A 1xzxX-4xq7A:
undetectable		 1xzxX-4xq7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135

(Acanthamoeba
polyphaga
mimivirus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A 267
ILE A 266
ALA A 273
LEU A  36
ILE A  34
 None
 1.16A 1xzxX-4z26A:
undetectable		 1xzxX-4z26A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn7 MALTODEXTRIN
GLUCOSIDASE

(Escherichia
coli) 		PF00128
(Alpha-amylase) 		5 ILE A 319
ILE A 312
LEU A 335
ILE A 370
HIS A 353
 None
 1.07A 1xzxX-5bn7A:
undetectable		 1xzxX-5bn7A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce6 FACT-SPT16

(Cicer arietinum) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ILE A  93
ARG A 113
LEU A  77
ILE A  23
PHE A  88
 None
 1.12A 1xzxX-5ce6A:
undetectable		 1xzxX-5ce6A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee0 OBG-LIKE ATPASE 1

(Oryza sativa) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		5 ILE A  95
ILE A  29
LEU A  90
ILE A 302
PHE A  40
 None
 1.24A 1xzxX-5ee0A:
undetectable		 1xzxX-5ee0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		5 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.94A 1xzxX-5egeA:
undetectable		 1xzxX-5egeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 ILE A 266
MET A 300
LEU A 369
ILE A 244
PHE A 287
 None
 1.02A 1xzxX-5ekuA:
undetectable		 1xzxX-5ekuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guh PIWI

(Bombyx mori) 		PF02170
(PAZ)
PF02171
(Piwi) 		5 ILE A 737
ILE A 776
ALA A 774
LEU A 853
ILE A 659
 None
 1.14A 1xzxX-5guhA:
undetectable		 1xzxX-5guhA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF01326
(PPDK_N) 		5 ILE A  92
ALA A  47
MET A 100
LEU A 146
ILE A 182
 None
 1.17A 1xzxX-5hv6A:
undetectable		 1xzxX-5hv6A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 ILE A 291
ILE A 292
ALA A 255
ILE A 433
PHE A 390
 None
 1.21A 1xzxX-5j6bA:
undetectable		 1xzxX-5j6bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxb DISKS LARGE HOMOLOG
4,SYNGAP

(Homo sapiens;
Mus musculus) 		PF00595
(PDZ) 		5 ILE A 311
ILE A 313
ALA A 344
LEU A 376
ILE A 324
 None
 1.26A 1xzxX-5jxbA:
undetectable		 1xzxX-5jxbA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 ILE A 536
ILE A 535
ALA A 538
ARG A 541
PHE A 352
 None
 1.24A 1xzxX-5k3jA:
undetectable		 1xzxX-5k3jA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ILE A 204
ILE A 208
LEU A 227
ILE A 169
PHE A 212
 None
 1.10A 1xzxX-5kc8A:
undetectable		 1xzxX-5kc8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF01094
(ANF_receptor) 		5 ILE A 261
ILE A 231
LEU A 185
ILE A 178
PHE A 168
 None
 1.15A 1xzxX-5kc8A:
undetectable		 1xzxX-5kc8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		5 ILE A 747
ILE A 717
LEU A 671
ILE A 664
PHE A 654
 None
 1.14A 1xzxX-5kcaA:
undetectable		 1xzxX-5kcaA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2e GLUTAMATE RECEPTOR
IONOTROPIC,
DELTA-2,GLUTAMATE
RECEPTOR IONOTROPIC,
DELTA-2

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 ILE A 261
ILE A 231
LEU A 185
ILE A 178
PHE A 168
 None
 1.22A 1xzxX-5l2eA:
undetectable		 1xzxX-5l2eA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m95 DIVALENT METAL
CATION TRANSPORTER
MNTH

(Staphylococcus
capitis) 		PF01566
(Nramp) 		5 ILE A 372
ILE A 369
LEU A 371
LEU A 384
ILE A 129
 None
 1.21A 1xzxX-5m95A:
undetectable		 1xzxX-5m95A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Desulfovibrio
vulgaris) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A  38
ILE A  39
ALA A  42
LEU A  55
ILE A  89
 None
 1.24A 1xzxX-5tx7A:
undetectable		 1xzxX-5tx7A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v77 UNCHARACTERIZED
PROTEIN

(Neisseria
gonorrhoeae) 		no annotation 5 ILE A  98
ILE A  93
LEU A  11
ILE A  69
PHE A  47
 None
 1.07A 1xzxX-5v77A:
undetectable		 1xzxX-5v77A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		5 ILE A 170
ALA A 137
LEU A 233
ILE A 235
PHE A 174
 None
 1.22A 1xzxX-5vemA:
undetectable		 1xzxX-5vemA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26

(Saccharomyces
cerevisiae) 		no annotation 5 ILE M 330
ILE M 333
ALA M 334
ILE M 494
PHE M 365
 None
 1.22A 1xzxX-5vvrM:
undetectable		 1xzxX-5vvrM:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 5 ILE A 466
ILE A 465
ALA A 414
LEU A 427
ILE A 498
 None
 1.18A 1xzxX-5w6mA:
undetectable		 1xzxX-5w6mA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 5 ILE A 693
ALA A 689
LEU A 665
LEU A 595
ILE A 591
 None
 1.23A 1xzxX-5wblA:
undetectable		 1xzxX-5wblA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		5 ILE O1180
ILE O1108
MET O1119
LEU O1211
LEU O1096
 None
 1.21A 1xzxX-5x0yO:
undetectable		 1xzxX-5x0yO:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9j PRHC

(Penicillium
brasilianum) 		no annotation 5 ILE A  20
ILE A  21
LEU A  32
LEU A 112
PHE A  72
 None
 1.14A 1xzxX-5x9jA:
undetectable		 1xzxX-5x9jA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 ILE B 183
ILE B 158
LEU B 150
LEU B 140
ILE B 107
 None
 1.21A 1xzxX-5y59B:
undetectable		 1xzxX-5y59B:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yww NUCLEOTIDE BINDING
PROTEIN PINC

(Sulfolobus
islandicus) 		no annotation 5 ILE A 252
ILE A 253
ALA A 254
LEU A 240
PHE A 264
 None
 1.20A 1xzxX-5ywwA:
undetectable		 1xzxX-5ywwA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gww PEROXIREDOXIN

(Sulfolobus
islandicus) 		no annotation 5 ILE A 153
ILE A 157
ALA A 156
ARG A 155
ILE A   9
 None
 1.11A 1xzxX-6gwwA:
undetectable		 1xzxX-6gwwA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		3 PHE A 227
ARG A 249
ASN A 263
 None
 0.73A 1xzxX-1bxcA:
0.0		 1xzxX-1bxcA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		3 PHE A 470
ARG A 380
ASN A 396
 None
 0.59A 1xzxX-1d4eA:
0.0		 1xzxX-1d4eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj0 PSEUDOURIDINE
SYNTHASE I

(Escherichia
coli) 		PF01416
(PseudoU_synth_1) 		3 PHE A 161
ARG A 205
ASN A 206
 None
 0.70A 1xzxX-1dj0A:
0.0		 1xzxX-1dj0A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dv8 ASIALOGLYCOPROTEIN
RECEPTOR 1

(Homo sapiens) 		PF00059
(Lectin_C) 		3 PHE A 257
ARG A 270
ASN A 208
 None
CL  A1004 (-4.4A)
None
 0.87A 1xzxX-1dv8A:
0.0		 1xzxX-1dv8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ft4 SOLUBLE TUMOR
NECROSIS FACTOR
RECEPTOR 1

(Homo sapiens) 		PF00020
(TNFR_c6) 		3 PHE A  60
ARG A  68
ASN A  65
 703  A 962 ( 4.9A)
None
None
 0.86A 1xzxX-1ft4A:
undetectable		 1xzxX-1ft4A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		3 PHE A 456
ARG A 397
ASN A 386
 None
 0.79A 1xzxX-1h39A:
0.0		 1xzxX-1h39A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 PHE B  71
ARG B 178
ASN B  65
 None
 0.91A 1xzxX-1hr7B:
0.0		 1xzxX-1hr7B:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		3 PHE A  99
ARG A 328
ASN A  91
 None
 0.88A 1xzxX-1kp2A:
undetectable		 1xzxX-1kp2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 PHE A  30
ARG A  21
ASN A 106
 None
 0.93A 1xzxX-1kpiA:
0.0		 1xzxX-1kpiA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ljy MGP-40

(Capra hircus) 		PF00704
(Glyco_hydro_18) 		3 PHE A  85
ARG A  96
ASN A  43
 None
 0.92A 1xzxX-1ljyA:
undetectable		 1xzxX-1ljyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 PHE A 353
ARG A 364
ASN A 238
 RS7  A 841 (-4.7A)
None
None
 0.81A 1xzxX-1loxA:
undetectable		 1xzxX-1loxA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		3 PHE A 257
ARG A 177
ASN A 112
 None
 0.92A 1xzxX-1mnnA:
undetectable		 1xzxX-1mnnA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		3 PHE A 433
ARG A 143
ASN A 382
 None
 0.87A 1xzxX-1mqqA:
undetectable		 1xzxX-1mqqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 PHE A  12
ARG A  59
ASN A  14
 None
 0.89A 1xzxX-1np7A:
undetectable		 1xzxX-1np7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvg DNA TOPOISOMERASE II

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		3 PHE A 304
ARG A 287
ASN A 306
 None
 0.87A 1xzxX-1pvgA:
undetectable		 1xzxX-1pvgA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 PHE A 272
ARG A 316
ASN A 331
 G24  A 462 (-4.9A)
None
None
 0.56A 1xzxX-1q4xA:
37.5		 1xzxX-1q4xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxq YFIT

(Bacillus
subtilis) 		PF12867
(DinB_2) 		3 PHE A  79
ARG A  91
ASN A  74
 None
 0.93A 1xzxX-1rxqA:
undetectable		 1xzxX-1rxqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		3 PHE A 203
ARG A 501
ASN A 209
 None
 0.89A 1xzxX-1sy7A:
undetectable		 1xzxX-1sy7A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA) 		3 PHE A  70
ARG A 266
ASN A 124
 None
SO4  A 321 (-3.6A)
SO4  A 321 (-3.0A)
 0.89A 1xzxX-1tltA:
undetectable		 1xzxX-1tltA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5f PYRUVATE OXIDASE

(Aerococcus
viridans) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 PHE A 282
ARG A 409
ASN A 242
 FAD  A1601 (-4.1A)
None
None
 0.92A 1xzxX-1v5fA:
undetectable		 1xzxX-1v5fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vff BETA-GLUCOSIDASE

(Pyrococcus
horikoshii) 		PF00232
(Glyco_hydro_1) 		3 PHE A 118
ARG A  75
ASN A  27
 None
 0.93A 1xzxX-1vffA:
undetectable		 1xzxX-1vffA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		3 PHE A 644
ARG A 662
ASN A 646
 None
 0.85A 1xzxX-1vrqA:
undetectable		 1xzxX-1vrqA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wjp ZINC FINGER PROTEIN
295

(Homo sapiens) 		no annotation 3 PHE A  53
ARG A  20
ASN A  23
 None
 0.84A 1xzxX-1wjpA:
undetectable		 1xzxX-1wjpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 PHE A 217
ARG A 245
ASN A 267
 None
 0.89A 1xzxX-1xkhA:
undetectable		 1xzxX-1xkhA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynx REPLICATION FACTOR-A
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF01336
(tRNA_anti-codon) 		3 PHE A 222
ARG A 282
ASN A 279
 None
 0.63A 1xzxX-1ynxA:
undetectable		 1xzxX-1ynxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2a RAS-RELATED PROTEIN
RAB-23

(Mus musculus) 		PF00071
(Ras) 		3 PHE A 162
ARG A 149
ASN A 157
 None
 0.85A 1xzxX-1z2aA:
undetectable		 1xzxX-1z2aA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 PHE C 264
ARG C  94
ASN C  99
 None
HEM  C 501 (-2.7A)
None
 0.94A 1xzxX-1zrtC:
undetectable		 1xzxX-1zrtC:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwq REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2

(Rattus
norvegicus) 		PF00168
(C2) 		3 PHE A 798
ARG A 811
ASN A 779
 None
 0.82A 1xzxX-2bwqA:
undetectable		 1xzxX-2bwqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01156
(IU_nuc_hydro) 		3 PHE A 175
ARG A 156
ASN A 160
 None
None
RIB  A1312 (-3.3A)
 0.91A 1xzxX-2c40A:
undetectable		 1xzxX-2c40A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		3 PHE A 351
ARG A 367
ASN A 374
 None
 0.90A 1xzxX-2d7dA:
undetectable		 1xzxX-2d7dA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4o PEPTIDE N-GLYCANASE

(Mus musculus) 		PF01841
(Transglut_core) 		3 PHE A 289
ARG A 255
ASN A 277
 None
 0.88A 1xzxX-2f4oA:
undetectable		 1xzxX-2f4oA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		3 PHE A 645
ARG A 663
ASN A 647
 None
 0.84A 1xzxX-2gahA:
undetectable		 1xzxX-2gahA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3

(Homo sapiens) 		no annotation 3 PHE A 426
ARG A 415
ASN A 465
 None
 0.93A 1xzxX-2gkwA:
undetectable		 1xzxX-2gkwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)

(West Nile virus) 		PF00972
(Flavi_NS5) 		3 PHE A 685
ARG A 543
ASN A 687
 None
 0.86A 1xzxX-2hcsA:
undetectable		 1xzxX-2hcsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iae SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		3 PHE B  53
ARG B 105
ASN B 102
 None
 0.86A 1xzxX-2iaeB:
undetectable		 1xzxX-2iaeB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		3 PHE A 217
ARG A 245
ASN A 267
 None
 0.90A 1xzxX-2o5pA:
undetectable		 1xzxX-2o5pA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 3 PHE A 880
ARG A 318
ASN A 319
 None
 0.68A 1xzxX-2po4A:
undetectable		 1xzxX-2po4A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		3 PHE A 214
ARG A 171
ASN A 172
 None
 0.92A 1xzxX-2pziA:
undetectable		 1xzxX-2pziA:
17.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		3 PHE A 312
ARG A 301
ASN A 181
 None
 0.94A 1xzxX-2q60A:
19.5		 1xzxX-2q60A:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 PHE A 290
ARG A 268
ASN A 318
 None
 0.76A 1xzxX-2wyaA:
undetectable		 1xzxX-2wyaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PHE A  58
ARG A  49
ASN A  83
 None
 0.75A 1xzxX-2yfkA:
undetectable		 1xzxX-2yfkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PHE A  58
ARG A 394
ASN A  83
 None
 0.67A 1xzxX-2yfkA:
undetectable		 1xzxX-2yfkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygt DELTA TOXIN

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		3 PHE A 175
ARG A  86
ASN A 251
 None
 0.85A 1xzxX-2ygtA:
undetectable		 1xzxX-2ygtA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 PHE A1247
ARG A1251
ASN A1218
 None
 0.84A 1xzxX-2zxqA:
undetectable		 1xzxX-2zxqA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3l KETOHEXOKINASE

(Homo sapiens) 		PF00294
(PfkB) 		3 PHE A 190
ARG A 141
ASN A  42
 None
 0.64A 1xzxX-3b3lA:
undetectable		 1xzxX-3b3lA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 3 PHE A  35
ARG A 369
ASN A 362
 None
 0.83A 1xzxX-3cv3A:
undetectable		 1xzxX-3cv3A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzt D7 PROTEIN

(Aedes aegypti) 		PF01395
(PBP_GOBP) 		3 PHE A 110
ARG A  57
ASN A  20
 None
 0.76A 1xzxX-3dztA:
undetectable		 1xzxX-3dztA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 PHE A1206
ARG A1210
ASN A1177
 None
 0.83A 1xzxX-3ecqA:
undetectable		 1xzxX-3ecqA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		3 PHE A 100
ARG A  83
ASN A 106
 None
EDO  A 534 (-4.1A)
None
 0.89A 1xzxX-3f6tA:
undetectable		 1xzxX-3f6tA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 PHE A 389
ARG A 375
ASN A 374
 None
 0.91A 1xzxX-3g1uA:
undetectable		 1xzxX-3g1uA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 PHE B1119
ARG A 452
ASN A 494
 None
 0.79A 1xzxX-3h0gB:
undetectable		 1xzxX-3h0gB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 PHE A  58
ARG A 165
ASN A  52
 None
 0.76A 1xzxX-3h1lA:
undetectable		 1xzxX-3h1lA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4u ATP-DEPENDENT RNA
HELICASE DHX8

(Homo sapiens) 		PF04408
(HA2)
PF07717
(OB_NTP_bind) 		3 PHE A1035
ARG A1079
ASN A1050
 None
GOL  A  11 (-4.0A)
None
 0.78A 1xzxX-3i4uA:
undetectable		 1xzxX-3i4uA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9f PUTATIVE TYPE 11
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF08241
(Methyltransf_11) 		3 PHE A  95
ARG A 141
ASN A  97
 None
 0.80A 1xzxX-3i9fA:
undetectable		 1xzxX-3i9fA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF05960
(DUF885) 		3 PHE A 458
ARG A 471
ASN A 489
 None
 0.87A 1xzxX-3iukA:
undetectable		 1xzxX-3iukA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 PHE A 366
ARG A  56
ASN A 383
 None
 0.72A 1xzxX-3iv0A:
undetectable		 1xzxX-3iv0A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		3 PHE A 227
ARG A 240
ASN A 229
 None
 0.63A 1xzxX-3jbhA:
undetectable		 1xzxX-3jbhA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngf AP ENDONUCLEASE,
FAMILY 2

(Brucella
abortus) 		PF01261
(AP_endonuc_2) 		3 PHE A  12
ARG A 210
ASN A   7
 None
 0.74A 1xzxX-3ngfA:
undetectable		 1xzxX-3ngfA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		3 PHE A 225
ARG A 222
ASN A 238
 None
 0.93A 1xzxX-3o5dA:
undetectable		 1xzxX-3o5dA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q98 TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PHE A  58
ARG A  49
ASN A  83
 None
 0.82A 1xzxX-3q98A:
undetectable		 1xzxX-3q98A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q98 TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 PHE A  58
ARG A 394
ASN A  83
 None
 0.90A 1xzxX-3q98A:
undetectable		 1xzxX-3q98A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk3 BETA-CRYSTALLIN B3

(Homo sapiens) 		PF00030
(Crystall) 		3 PHE A 124
ARG A 127
ASN A 121
 None
 0.93A 1xzxX-3qk3A:
undetectable		 1xzxX-3qk3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		3 PHE A 353
ARG A 364
ASN A 238
 None
 0.83A 1xzxX-3rdeA:
undetectable		 1xzxX-3rdeA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9

(Veillonella
parvula) 		PF01075
(Glyco_transf_9) 		3 PHE A 187
ARG A 197
ASN A 265
 None
 0.84A 1xzxX-3tovA:
undetectable		 1xzxX-3tovA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaj ENVELOPE PROTEIN

(Dengue virus) 		no annotation 3 PHE B 193
ARG B 167
ASN B 134
 None
 0.76A 1xzxX-3uajB:
undetectable		 1xzxX-3uajB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ud2 ANKYRIN-1

(Homo sapiens) 		no annotation 3 PHE C1203
ARG C1143
ASN C1206
 None
 0.95A 1xzxX-3ud2C:
undetectable		 1xzxX-3ud2C:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj1 THIOREDOXIN
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 PHE A 332
ARG A 385
ASN A 386
 None
 0.91A 1xzxX-3uj1A:
undetectable		 1xzxX-3uj1A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1e FLAGELLA BASAL-BODY
PROTEIN

(Vibrio
alginolyticus) 		PF16538
(FlgT_C)
PF16539
(FlgT_M)
PF16548
(FlgT_N) 		3 PHE A 141
ARG A 132
ASN A 131
 None
 0.90A 1xzxX-3w1eA:
undetectable		 1xzxX-3w1eA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		3 PHE A 446
ARG A 449
ASN A 499
 None
 0.83A 1xzxX-3x3yA:
undetectable		 1xzxX-3x3yA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 PHE A1160
ARG A 947
ASN A 892
 None
 0.75A 1xzxX-3zyvA:
undetectable		 1xzxX-3zyvA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 PHE A 467
ARG A 189
ASN A 155
 None
 0.93A 1xzxX-4b90A:
undetectable		 1xzxX-4b90A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		3 PHE A 304
ARG A 287
ASN A 306
 None
 0.92A 1xzxX-4gfhA:
1.3		 1xzxX-4gfhA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE

(Thermotoga
maritima) 		PF09861
(DUF2088) 		3 PHE A 101
ARG A 136
ASN A 135
 None
 0.71A 1xzxX-4narA:
undetectable		 1xzxX-4narA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		3 PHE B 716
ARG B 597
ASN B 598
 None
 0.85A 1xzxX-4oavB:
undetectable		 1xzxX-4oavB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on0 NOLR

(Sinorhizobium
fredii) 		PF01022
(HTH_5) 		3 PHE A  22
ARG A  67
ASN A  70
 None
 0.95A 1xzxX-4on0A:
undetectable		 1xzxX-4on0A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p13 MEDIUM-CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 PHE A  78
ARG A 256
ASN A 325
 None
 0.86A 1xzxX-4p13A:
undetectable		 1xzxX-4p13A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pag PERIPLASMIC BINDING
PROTEIN

(Sulfurospirillum
deleyianum) 		PF01497
(Peripla_BP_2) 		3 PHE A 338
ARG A 293
ASN A 283
 None
 0.71A 1xzxX-4pagA:
undetectable		 1xzxX-4pagA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qma CYSTEINE DIOXYGENASE
TYPE I

(Cupriavidus
pinatubonensis) 		PF05995
(CDO_I) 		3 PHE A  83
ARG A 130
ASN A 151
 OXY  A 302 (-4.5A)
None
None
 0.92A 1xzxX-4qmaA:
undetectable		 1xzxX-4qmaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r30 LAFORIN

(Homo sapiens) 		PF00782
(DSPc) 		3 PHE A 192
ARG A 171
ASN A 267
 None
None
SO4  A 501 (-4.6A)
 0.87A 1xzxX-4r30A:
undetectable		 1xzxX-4r30A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up5 PYGOPUS HOMOLOG 2,
B-CELL CLL/LYMPHOMA
9-LIKE PROTEIN

(Homo sapiens) 		PF00628
(PHD) 		3 PHE A1238
ARG A 356
ASN A1244
 None
 0.93A 1xzxX-4up5A:
undetectable		 1xzxX-4up5A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		3 PHE A2212
ARG A2202
ASN A2205
 None
 0.90A 1xzxX-4x0qA:
undetectable		 1xzxX-4x0qA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yiv APICAL MEMBRANE
ANTIGEN AMA1

(Toxoplasma
gondii) 		PF02430
(AMA-1) 		3 PHE A  85
ARG A 369
ASN A 370
 None
 0.86A 1xzxX-4yivA:
undetectable		 1xzxX-4yivA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4

(Saccharomyces
cerevisiae) 		PF01793
(Glyco_transf_15) 		3 PHE A 267
ARG A 405
ASN A 416
 None
 0.94A 1xzxX-5a08A:
undetectable		 1xzxX-5a08A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 PHE A1206
ARG A1210
ASN A1177
 None
 0.90A 1xzxX-5a55A:
undetectable		 1xzxX-5a55A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bug PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
3-PHOSPHATASE AND
DUAL-SPECIFICITY
PROTEIN PHOSPHATASE
PTEN

(Homo sapiens) 		PF00782
(DSPc)
PF10409
(PTEN_C2) 		3 PHE A 271
ARG A 172
ASN A 329
 None
 0.92A 1xzxX-5bugA:
undetectable		 1xzxX-5bugA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8s GUANINE-N7
METHYLTRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		3 PHE B 426
ARG B  84
ASN B 410
 G3A  B 606 (-3.4A)
None
None
 0.91A 1xzxX-5c8sB:
undetectable		 1xzxX-5c8sB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 PHE A  98
ARG A 487
ASN A  95
 None
 0.91A 1xzxX-5ek8A:
undetectable		 1xzxX-5ek8A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 PHE z 136
ARG z 511
ASN z 410
 None
 0.85A 1xzxX-5gw5z:
undetectable		 1xzxX-5gw5z:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1u GERMACRADIEN-4-OL
SYNTHASE

(Streptomyces
citricolor) 		no annotation 3 PHE A 216
ARG A 240
ASN A 234
 None
 0.86A 1xzxX-5i1uA:
undetectable		 1xzxX-5i1uA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 PHE A1389
ARG A1422
ASN A 858
 None
 0.88A 1xzxX-5ip9A:
undetectable		 1xzxX-5ip9A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpv ASIALOGLYCOPROTEIN
RECEPTOR 1

(Homo sapiens) 		PF00059
(Lectin_C) 		3 PHE A 257
ARG A 270
ASN A 208
 None
CL  A 305 (-4.4A)
None
 0.94A 1xzxX-5jpvA:
undetectable		 1xzxX-5jpvA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly8 TAIL COMPONENT

(Lactobacillus
phage J-1) 		no annotation 3 PHE A  54
ARG A  99
ASN A 225
 None
 0.89A 1xzxX-5ly8A:
undetectable		 1xzxX-5ly8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		3 PHE A 311
ARG A 587
ASN A 353
 None
 0.63A 1xzxX-5n6uA:
undetectable		 1xzxX-5n6uA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfq EPOXIDE HYDROLASE
BELONGING TO
ALPHA/BETA HYDROLASE
SUPERFAMILY
METAGENOMIC FROM
TOMSK SAMPLE

(metagenome) 		no annotation 3 PHE A 203
ARG A  64
ASN A 198
 None
 0.87A 1xzxX-5nfqA:
undetectable		 1xzxX-5nfqA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukh UNCHARACTERIZED
PROTEIN

(Streptococcus
intermedius) 		no annotation 3 PHE A 274
ARG A 296
ASN A 414
 None
 0.87A 1xzxX-5ukhA:
undetectable		 1xzxX-5ukhA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		3 PHE B 316
ARG B  46
ASN B 247
 None
 0.76A 1xzxX-5w3jB:
undetectable		 1xzxX-5w3jB:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B
ALTERNATIVE COMPLEX
III SUBUNIT C

(Flavobacterium
johnsoniae) 		no annotation 3 PHE B 899
ARG C 136
ASN B 897
 None
 0.94A 1xzxX-6btmB:
undetectable		 1xzxX-6btmB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 3 PHE C 187
ARG C 228
ASN C 230
 None
 0.90A 1xzxX-6cajC:
undetectable		 1xzxX-6cajC:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 3 PHE A 771
ARG A 816
ASN A 787
 None
 0.67A 1xzxX-6fa5A:
undetectable		 1xzxX-6fa5A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fri ALKANAL
MONOOXYGENASE BETA
CHAIN

(Photobacterium
leiognathi) 		no annotation 3 PHE A  42
ARG A 195
ASN A  77
 None
 0.61A 1xzxX-6friA:
undetectable		 1xzxX-6friA:
13.62