SIMILAR PATTERNS OF AMINO ACIDS FOR 1XZ1_A_HLTA2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnt CILIARY NEUROTROPHIC
FACTOR

(Homo sapiens) 		PF01110
(CNTF) 		4 LEU 1  34
SER 1  37
TYR 1  38
LEU 1 162
 None
 1.23A 1xz1A-1cnt1:
6.0		 1xz1A-1cnt1:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exc PROTEIN MAF

(Bacillus
subtilis) 		PF02545
(Maf) 		4 LEU A 173
SER A 169
TYR A 168
LEU A  17
 None
 1.16A 1xz1A-1excA:
undetectable		 1xz1A-1excA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5m GAF

(Saccharomyces
cerevisiae) 		PF13185
(GAF_2) 		4 LEU A  28
SER A  31
TYR A  32
LEU A 169
 None
 1.29A 1xz1A-1f5mA:
0.3		 1xz1A-1f5mA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU A 559
SER A 562
TYR A 563
LEU A 555
 None
 0.82A 1xz1A-1ldjA:
0.5		 1xz1A-1ldjA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lki LEUKEMIA INHIBITORY
FACTOR

(Mus musculus) 		PF01291
(LIF_OSM) 		4 LEU A  40
SER A  43
TYR A  44
LEU A 166
 None
 0.87A 1xz1A-1lkiA:
5.8		 1xz1A-1lkiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqy PEPTIDE DEFORMYLASE
2

(Geobacillus
stearothermophilus) 		PF01327
(Pep_deformylase) 		4 LEU A  37
SER A  36
TYR A  40
LEU A  61
 None
 1.21A 1xz1A-1lqyA:
undetectable		 1xz1A-1lqyA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0w GLUTATHIONE
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 LEU A 107
SER A 106
TYR A 108
LEU A 316
 None
 1.29A 1xz1A-1m0wA:
undetectable		 1xz1A-1m0wA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwi OSMOTICALLY
INDUCIBLE PROTEIN

(Escherichia
coli) 		PF02566
(OsmC) 		4 LEU A 100
SER A 102
TYR A 139
LEU A 137
 None
 1.21A 1xz1A-1qwiA:
undetectable		 1xz1A-1qwiA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		4 LEU A 135
SER A 138
TYR A 139
LEU A  57
 None
 0.93A 1xz1A-1r4pA:
0.0		 1xz1A-1r4pA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		4 LEU A  19
SER A  57
TYR A  59
LEU A 277
 None
 1.14A 1xz1A-1to3A:
undetectable		 1xz1A-1to3A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU D 131
SER D 108
TYR D 130
LEU D 129
 None
 1.28A 1xz1A-1u0nD:
undetectable		 1xz1A-1u0nD:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlv ORNITHINE
CARBAMOYLTRANSFERASE

(Thermotoga
maritima) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 118
SER A 122
TYR A 121
LEU A  91
 None
 1.31A 1xz1A-1vlvA:
undetectable		 1xz1A-1vlvA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdn RNA EDITING LIGASE
MP52

(Trypanosoma
brucei) 		PF09414
(RNA_ligase) 		4 LEU A 270
SER A 201
TYR A 200
LEU A 266
 None
 1.27A 1xz1A-1xdnA:
undetectable		 1xz1A-1xdnA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 LEU A 214
SER A 212
TYR A 224
LEU A 222
 None
 1.15A 1xz1A-1yr2A:
undetectable		 1xz1A-1yr2A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO

(Schizosaccharomyces
pombe) 		no annotation 4 LEU A 129
SER A 102
TYR A 128
LEU A 127
 None
 1.25A 1xz1A-1yrgA:
undetectable		 1xz1A-1yrgA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3j HYPOTHETICAL PROTEIN
PA4359

(Pseudomonas
aeruginosa) 		PF04023
(FeoA) 		4 LEU A  68
SER A  16
TYR A  15
LEU A  27
 None
 1.02A 1xz1A-2h3jA:
undetectable		 1xz1A-2h3jA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx5 HYPOTHETICAL PROTEIN

(Prochlorococcus
marinus) 		PF13279
(4HBT_2) 		4 LEU A  41
SER A  40
TYR A  44
LEU A  46
 ETX  A 152 ( 4.1A)
None
None
ETX  A 152 ( 4.7A)
 1.12A 1xz1A-2hx5A:
undetectable		 1xz1A-2hx5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE

(Synechococcus
elongatus) 		PF13672
(PP2C_2) 		4 LEU A 208
SER A 209
TYR A 207
LEU A 220
 None
 1.12A 1xz1A-2j86A:
undetectable		 1xz1A-2j86A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nra PI PROTEIN

(Escherichia
coli) 		PF01051
(Rep_3) 		4 LEU C 174
SER C 171
TYR C 170
LEU C 202
 None
 0.83A 1xz1A-2nraC:
undetectable		 1xz1A-2nraC:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 LEU B 473
SER B 470
TYR B 469
LEU B 447
 None
 1.21A 1xz1A-2o8eB:
2.3		 1xz1A-2o8eB:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2w CITRATE SYNTHASE

(Thermotoga
maritima) 		PF00285
(Citrate_synt) 		4 LEU A 306
SER A 303
TYR A 302
LEU A 267
 None
 1.14A 1xz1A-2p2wA:
undetectable		 1xz1A-2p2wA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II

(Caldanaerobacter
subterraneus) 		PF00753
(Lactamase_B) 		4 LEU A 252
SER A 274
TYR A 275
LEU A 276
 None
 1.22A 1xz1A-2p4zA:
undetectable		 1xz1A-2p4zA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq8 TBC1 DOMAIN FAMILY
MEMBER 14

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 LEU A 575
SER A 577
TYR A 576
LEU A 600
 None
 1.22A 1xz1A-2qq8A:
undetectable		 1xz1A-2qq8A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA

(Escherichia
coli) 		PF02563
(Poly_export)
PF10531
(SLBB) 		4 LEU A  79
SER A  82
TYR A  83
LEU A 240
 None
 1.05A 1xz1A-2w8iA:
undetectable		 1xz1A-2w8iA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 323
SER A 324
TYR A 326
LEU A 297
 None
 1.11A 1xz1A-2wd9A:
undetectable		 1xz1A-2wd9A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzv NFNB PROTEIN

(Mycolicibacterium
smegmatis) 		PF00881
(Nitroreductase) 		4 LEU A 183
SER A 184
TYR A 186
LEU A  77
 None
 1.16A 1xz1A-2wzvA:
undetectable		 1xz1A-2wzvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3m HYPOTHETICAL PROTEIN
ORF239

(Pyrobaculum
spherical virus) 		no annotation 4 LEU A 210
SER A 209
TYR A 211
LEU A 233
 None
 1.09A 1xz1A-2x3mA:
undetectable		 1xz1A-2x3mA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpi ANAPHASE-PROMOTING
COMPLEX SUBUNIT CUT9

(Schizosaccharomyces
pombe) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 LEU A 464
SER A 467
TYR A 468
LEU A 481
 None
 1.23A 1xz1A-2xpiA:
undetectable		 1xz1A-2xpiA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya3 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF16579
(AdenylateSensor) 		4 LEU A 461
SER A 402
TYR A 459
LEU A 451
 None
 1.28A 1xz1A-2ya3A:
undetectable		 1xz1A-2ya3A:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2za8 FERRITIN LIGHT CHAIN

(Equus caballus) 		PF00210
(Ferritin) 		4 LEU A  25
SER A  28
TYR A  29
LEU A  82
 None
 0.08A 1xz1A-2za8A:
28.7		 1xz1A-2za8A:
99.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a45 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Acanthamoeba
polyphaga
mimivirus) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		4 LEU A  23
SER A 101
TYR A  25
LEU A  48
 None
 1.19A 1xz1A-3a45A:
undetectable		 1xz1A-3a45A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adc L-SERYL-TRNA(SEC)
KINASE

(Methanocaldococcus
jannaschii) 		PF08433
(KTI12) 		4 LEU A 244
SER A 247
TYR A 248
LEU A 218
 None
 1.08A 1xz1A-3adcA:
undetectable		 1xz1A-3adcA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		no annotation 4 LEU E 349
SER E 352
TYR E 353
LEU E 107
 None
 1.30A 1xz1A-3aoeE:
undetectable		 1xz1A-3aoeE:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5q PUTATIVE SULFATASE
YIDJ

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 LEU A 430
SER A 427
TYR A 426
LEU A 407
 None
None
EDO  A 513 ( 4.2A)
None
 1.25A 1xz1A-3b5qA:
undetectable		 1xz1A-3b5qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c12 FLAGELLAR PROTEIN

(Xanthomonas
campestris) 		PF13860
(FlgD_ig)
PF13861
(FLgD_tudor) 		4 LEU A 180
SER A 178
TYR A 169
LEU A 168
 None
 1.31A 1xz1A-3c12A:
undetectable		 1xz1A-3c12A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dde TENA/THI-4 PROTEIN,
DOMAIN OF UNKNOWN
FUNCTION WITH A HEME
OXYGENASE-LIKE FOLD

(Shewanella
denitrificans) 		PF14518
(Haem_oxygenas_2) 		4 LEU A 133
SER A 136
TYR A 137
LEU A 185
 None
 1.23A 1xz1A-3ddeA:
7.7		 1xz1A-3ddeA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP3

(Rhinovirus A) 		PF00073
(Rhv) 		4 LEU C 209
SER C  69
TYR C  68
LEU C  52
 None
 0.87A 1xz1A-3dprC:
undetectable		 1xz1A-3dprC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dte IRRE PROTEIN

(Deinococcus
deserti) 		PF06114
(Peptidase_M78) 		4 LEU A  21
SER A  24
TYR A  25
LEU A  88
 None
 1.26A 1xz1A-3dteA:
undetectable		 1xz1A-3dteA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcx S-FORMYLGLUTATHIONE
HYDROLASE

(Homo sapiens) 		PF00756
(Esterase) 		4 LEU A 207
SER A 210
TYR A 211
LEU A 160
 None
 1.10A 1xz1A-3fcxA:
undetectable		 1xz1A-3fcxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214

(Homo sapiens) 		PF12894
(ANAPC4_WD40) 		4 LEU A 317
SER A 308
TYR A 309
LEU A 315
 None
 1.08A 1xz1A-3fhcA:
undetectable		 1xz1A-3fhcA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0w 8-OXOGUANINE-DNA-GLY
COSYLASE

(Clostridium
acetobutylicum) 		PF00730
(HhH-GPD)
PF07934
(OGG_N) 		4 LEU A  98
SER A 101
TYR A 280
LEU A  92
 None
 1.21A 1xz1A-3i0wA:
undetectable		 1xz1A-3i0wA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9u HEME OXYGENASE 1

(Rattus
norvegicus) 		PF01126
(Heme_oxygenase) 		4 LEU A  54
SER A  53
TYR A  55
LEU A  89
 None
 1.19A 1xz1A-3i9uA:
4.2		 1xz1A-3i9uA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv1 TRANSCRIPTIONAL
REPRESSOR

(Aliivibrio
fischeri) 		PF04198
(Sugar-bind) 		4 LEU A  41
SER A  44
TYR A  45
LEU A  23
 GOL  A 284 (-4.3A)
GOL  A 284 (-3.2A)
None
GOL  A 284 ( 4.4A)
 1.26A 1xz1A-3kv1A:
undetectable		 1xz1A-3kv1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		4 LEU X 474
SER X 477
TYR X  33
LEU X  27
 None
 1.25A 1xz1A-3lxuX:
2.5		 1xz1A-3lxuX:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 LEU A  15
SER A  18
TYR A  19
LEU A 240
 None
 1.32A 1xz1A-3nksA:
undetectable		 1xz1A-3nksA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 546
SER A 549
TYR A 548
LEU A 510
 None
 1.24A 1xz1A-3omvA:
2.1		 1xz1A-3omvA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdk PHOSPHOGLUCOSAMINE
MUTASE

(Bacillus
anthracis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A 188
SER A 187
TYR A 191
LEU A 160
 None
 1.32A 1xz1A-3pdkA:
1.7		 1xz1A-3pdkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 LEU A 394
SER A 397
TYR A 398
LEU A 359
 None
 0.86A 1xz1A-3qmlA:
undetectable		 1xz1A-3qmlA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1

(Saccharomyces
cerevisiae) 		PF16782
(SIL1) 		4 LEU C 248
SER C 249
TYR C 247
LEU C 229
 None
 1.16A 1xz1A-3qmlC:
undetectable		 1xz1A-3qmlC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqy RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
PROTEIN FUSION

(Ophiostoma
novo-ulmi) 		PF00961
(LAGLIDADG_1) 		4 LEU A 215
SER A 214
TYR A 218
LEU A 219
 None
 1.31A 1xz1A-3qqyA:
undetectable		 1xz1A-3qqyA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz7 HSC70 COCHAPERONE
(SGT)

(Aspergillus
fumigatus) 		PF13181
(TPR_8)
PF13414
(TPR_11) 		4 LEU A 151
SER A 152
TYR A 150
LEU A 141
 None
 1.24A 1xz1A-3sz7A:
undetectable		 1xz1A-3sz7A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5z DNA POLYMERASE
ACCESSORY PROTEIN 44

(Escherichia
virus T4) 		PF00004
(AAA) 		4 LEU B 211
SER B 215
TYR B 214
LEU B 196
 None
 1.24A 1xz1A-3u5zB:
undetectable		 1xz1A-3u5zB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7f PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pyogenes) 		PF09711
(Cas_Csn2) 		4 LEU A 181
SER A 180
TYR A 184
LEU A 152
 None
 1.17A 1xz1A-3v7fA:
undetectable		 1xz1A-3v7fA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A3943
SER A3944
TYR A3942
LEU A3930
 None
 1.28A 1xz1A-3vkgA:
undetectable		 1xz1A-3vkgA:
4.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akd MANNOSE-SPECIFIC
LECTIN KM+

(Artocarpus
integer) 		PF01419
(Jacalin) 		4 LEU A 100
SER A  99
TYR A  34
LEU A  32
 None
 1.31A 1xz1A-4akdA:
undetectable		 1xz1A-4akdA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2g GH3-1 AUXIN
CONJUGATING ENZYME

(Vitis vinifera) 		PF03321
(GH3) 		4 LEU A 322
SER A 326
TYR A 325
LEU A 235
 None
None
MLI  A1598 (-4.3A)
None
 1.31A 1xz1A-4b2gA:
undetectable		 1xz1A-4b2gA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eag EG:132E8.2 PROTEIN

(Drosophila
melanogaster) 		PF16579
(AdenylateSensor) 		4 LEU A 525
SER A 466
TYR A 523
LEU A 515
 None
 1.18A 1xz1A-4eagA:
undetectable		 1xz1A-4eagA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Campylobacter
jejuni) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 LEU A 279
SER A 282
TYR A 283
LEU A 309
 None
 0.95A 1xz1A-4ehiA:
undetectable		 1xz1A-4ehiA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 CULLIN-1

(Homo sapiens) 		PF00888
(Cullin) 		4 LEU A 559
SER A 562
TYR A 563
LEU A 555
 None
 0.94A 1xz1A-4f52A:
undetectable		 1xz1A-4f52A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		4 LEU L 283
SER L 284
TYR L 416
LEU L 412
 None
 1.14A 1xz1A-4heaL:
2.7		 1xz1A-4heaL:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il3 STE24P

(Saccharomyces
mikatae) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		4 LEU A 426
SER A 429
TYR A 430
LEU A  33
 None
 0.91A 1xz1A-4il3A:
3.0		 1xz1A-4il3A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 LEU A 327
SER A 328
TYR A 326
LEU A 136
 None
 1.23A 1xz1A-4je5A:
undetectable		 1xz1A-4je5A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG

(Schizosaccharomyces
pombe) 		PF04388
(Hamartin) 		4 LEU A 150
SER A 153
TYR A 151
LEU A 175
 None
 1.27A 1xz1A-4kk1A:
undetectable		 1xz1A-4kk1A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		4 LEU A 272
SER A 269
TYR A 268
LEU A 303
 None
 1.22A 1xz1A-4kqkA:
undetectable		 1xz1A-4kqkA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 LEU A 306
SER A 308
TYR A 309
LEU A 292
 None
 1.28A 1xz1A-4logA:
2.9		 1xz1A-4logA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB

(Mycobacterium
tuberculosis) 		PF13416
(SBP_bac_8) 		4 LEU A 227
SER A 222
TYR A 221
LEU A 229
 None
 1.29A 1xz1A-4mfiA:
undetectable		 1xz1A-4mfiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6b SERINE
ACETYLTRANSFERASE
APOENZYME

(Glycine max) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 LEU A 113
SER A 110
TYR A 109
LEU A  96
 None
 1.09A 1xz1A-4n6bA:
undetectable		 1xz1A-4n6bA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptz FMN REDUCTASE SSUE

(Escherichia
coli) 		no annotation 4 LEU C  18
SER C  17
TYR C  21
LEU C 160
 None
 1.17A 1xz1A-4ptzC:
undetectable		 1xz1A-4ptzC:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r89 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08774
(VRR_NUC) 		4 LEU A 262
SER A 285
TYR A 282
LEU A 281
 None
 1.28A 1xz1A-4r89A:
undetectable		 1xz1A-4r89A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u06 LIC10831

(Leptospira
interrogans) 		PF12799
(LRR_4)
PF13855
(LRR_8) 		4 LEU A 191
SER A 169
TYR A 190
LEU A 189
 None
CL  A 406 (-3.0A)
CL  A 406 (-4.5A)
None
 1.31A 1xz1A-4u06A:
undetectable		 1xz1A-4u06A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus) 		PF01966
(HD) 		4 LEU A 331
SER A 241
TYR A 330
LEU A 321
 None
 1.29A 1xz1A-4uw2A:
undetectable		 1xz1A-4uw2A:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 LEU A 306
SER A 308
TYR A 309
LEU A 292
 None
 1.31A 1xz1A-4xaiA:
undetectable		 1xz1A-4xaiA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 LEU A 306
SER A 308
TYR A 309
LEU A 292
 None
 1.16A 1xz1A-4xajA:
2.2		 1xz1A-4xajA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 LEU A 611
SER A 614
TYR A 615
LEU A 447
 None
 1.01A 1xz1A-4z3yA:
undetectable		 1xz1A-4z3yA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zws RECOMBINATION
PROTEIN UVSY

(Escherichia
virus T4) 		PF11056
(UvsY) 		4 LEU A  61
SER A  65
TYR A  64
LEU A  87
 None
 1.25A 1xz1A-4zwsA:
4.2		 1xz1A-4zwsA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axh DEXTRANASE

(Thermoanaerobacter
pseudethanolicus) 		PF13199
(Glyco_hydro_66) 		4 LEU A 371
SER A 397
TYR A 396
LEU A 359
 None
 1.17A 1xz1A-5axhA:
undetectable		 1xz1A-5axhA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs2 HISTIDINE TRIAD
PROTEIN

(Plasmodium
falciparum) 		PF01230
(HIT) 		4 LEU A 189
SER A 192
TYR A 193
LEU A  91
 None
 1.13A 1xz1A-5cs2A:
undetectable		 1xz1A-5cs2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		4 LEU A 516
SER A 519
TYR A 517
LEU A 618
 None
 1.23A 1xz1A-5e3cA:
undetectable		 1xz1A-5e3cA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5o I-SMAMI LAGLIDADG
ENDONUCLEASE

(Sordaria
macrospora) 		PF00961
(LAGLIDADG_1) 		4 LEU A 217
SER A 216
TYR A 220
LEU A 221
 None
 1.27A 1xz1A-5e5oA:
undetectable		 1xz1A-5e5oA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 654
SER A 657
TYR A 656
LEU A 618
 None
 1.01A 1xz1A-5fd2A:
3.1		 1xz1A-5fd2A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		4 LEU A  38
SER A  35
TYR A  39
LEU A  42
 None
 1.26A 1xz1A-5gneA:
undetectable		 1xz1A-5gneA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 LEU A 196
SER A 197
TYR A 198
LEU A 389
 None
 1.16A 1xz1A-5h42A:
2.5		 1xz1A-5h42A:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		4 LEU A 592
SER A 591
TYR A 595
LEU A 596
 None
 1.23A 1xz1A-5hzrA:
undetectable		 1xz1A-5hzrA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5o MATRIX PROTEIN

(Thogoto
thogotovirus) 		PF17536
(Mx_ML) 		4 LEU A  87
SER A  90
TYR A  91
LEU A 115
 None
 1.24A 1xz1A-5i5oA:
undetectable		 1xz1A-5i5oA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		4 LEU A 159
SER A 160
TYR A 158
LEU A  75
 None
 1.30A 1xz1A-5l2rA:
undetectable		 1xz1A-5l2rA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1) 		4 LEU B 529
SER B 528
TYR B 532
LEU B 497
 None
 1.05A 1xz1A-5l3xB:
undetectable		 1xz1A-5l3xB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4c PROLYL
OLIGOPEPTIDASE

(Galerina
marginata) 		no annotation 4 LEU A  57
SER A  60
TYR A  61
LEU A 688
 None
 1.13A 1xz1A-5n4cA:
undetectable		 1xz1A-5n4cA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nj8 ARYL HYDROCARBON
RECEPTOR

(Homo sapiens) 		PF00010
(HLH)
PF00989
(PAS) 		4 LEU A  72
SER A  75
TYR A  76
LEU A  54
 None
 1.25A 1xz1A-5nj8A:
undetectable		 1xz1A-5nj8A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN

(Chaetomium
thermophilum) 		PF12569
(NARP1)
PF13432
(TPR_16) 		4 LEU A 231
SER A 232
TYR A 230
LEU A 207
 None
 1.19A 1xz1A-5nnpA:
2.8		 1xz1A-5nnpA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy7 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		4 LEU B 103
SER B 106
TYR B 107
LEU B  85
 None
 1.07A 1xz1A-5sy7B:
undetectable		 1xz1A-5sy7B:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2h I-ONUI_E-HTCRA

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		4 LEU A 215
SER A 214
TYR A 218
LEU A 219
 None
 1.26A 1xz1A-5t2hA:
undetectable		 1xz1A-5t2hA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2o I-ONUI_E-AG011377

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		4 LEU A 215
SER A 214
TYR A 218
LEU A 219
 None
 1.18A 1xz1A-5t2oA:
undetectable		 1xz1A-5t2oA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42

(Saccharomyces
cerevisiae) 		no annotation 4 LEU D 108
SER D 111
TYR D 112
LEU D  98
 None
 1.08A 1xz1A-5uz5D:
3.0		 1xz1A-5uz5D:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		4 LEU O 806
SER O 804
TYR O 808
LEU O 809
 None
 1.02A 1xz1A-5x0yO:
undetectable		 1xz1A-5x0yO:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x11 TRANSCRIPTIONAL
REGULATOR

(Bacillus
subtilis) 		no annotation 4 LEU A 131
SER A 134
TYR A 135
LEU A 162
 None
 1.09A 1xz1A-5x11A:
5.3		 1xz1A-5x11A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR

(Homo sapiens) 		PF00010
(HLH)
PF00989
(PAS) 		4 LEU A  73
SER A  76
TYR A  77
LEU A  55
 None
 0.65A 1xz1A-5y7yA:
undetectable		 1xz1A-5y7yA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 4 LEU A2314
SER A2313
TYR A2322
LEU A2262
 None
 1.20A 1xz1A-5yz0A:
undetectable		 1xz1A-5yz0A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN

(Escherichia
coli) 		no annotation 4 LEU A 305
SER A 307
TYR A 308
LEU A 291
 None
 1.14A 1xz1A-5z0rA:
undetectable		 1xz1A-5z0rA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 4 LEU C 339
SER C 341
TYR C 344
LEU C 274
 None
 1.18A 1xz1A-6cajC:
undetectable		 1xz1A-6cajC:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpc PRO-PRO
ENDOPEPTIDASE

(Paenibacillus
alvei) 		no annotation 4 LEU A  67
SER A  69
TYR A  68
LEU A  36
 None
 1.22A 1xz1A-6fpcA:
undetectable		 1xz1A-6fpcA:
18.97