SIMILAR PATTERNS OF AMINO ACIDS FOR 1XR2_B_C2FB1201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bm8 TRANSCRIPTION FACTOR
MBP1


(Saccharomyces
cerevisiae)
PF04383
(KilA-N)
4 SER A  11
ARG A   9
TRP A  77
GLU A  64
None
1.22A 1xr2B-1bm8A:
0.0
1xr2B-1bm8A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehi D-ALANINE:D-LACTATE
LIGASE


(Leuconostoc
mesenteroides)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
4 LYS A 180
THR A 244
SER A 187
GLU A 216
ADP  A 781 (-2.6A)
None
ADP  A 781 (-3.5A)
ADP  A 781 (-3.7A)
1.42A 1xr2B-1ehiA:
0.0
1xr2B-1ehiA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE


(Thermotoga
maritima)
PF01259
(SAICAR_synt)
4 LYS A 170
THR A  71
SER A 188
GLU A 172
None
1.29A 1xr2B-1kutA:
0.0
1xr2B-1kutA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb1 MLU1-BOX BINDING
PROTEIN


(Saccharomyces
cerevisiae)
PF04383
(KilA-N)
4 SER A  11
ARG A   9
TRP A  77
GLU A  64
None
1.22A 1xr2B-1mb1A:
0.0
1xr2B-1mb1A:
10.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE


(Arabidopsis
thaliana)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
4 LYS A  18
TRP A 514
SER A 517
TRP A 567
None
0.62A 1xr2B-1u1hA:
48.3
1xr2B-1u1hA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE


(Thermotoga
maritima)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
8 LYS A  18
LYS A 104
THR A 466
TRP A 486
SER A 489
ARG A 493
TRP A 539
GLU A 583
C2F  A1882 (-2.4A)
C2F  A1882 ( 3.3A)
None
None
C2F  A1882 (-3.0A)
C2F  A1882 ( 3.5A)
C2F  A1882 (-3.7A)
C2F  A1882 (-3.0A)
0.73A 1xr2B-1xpgA:
64.2
1xr2B-1xpgA:
99.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w37 ORNITHINE
CARBAMOYLTRANSFERASE
, CATABOLIC


(Lactobacillus
hilgardii)
PF00185
(OTCace)
PF02729
(OTCace_N)
4 LYS A  37
THR A 180
SER A 326
GLU A 153
None
1.48A 1xr2B-2w37A:
0.5
1xr2B-2w37A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT


(Arabidopsis
thaliana)
PF00503
(G-alpha)
4 LYS A  59
LYS A 288
THR A 194
GLU A 247
None
GSP  A1382 (-3.1A)
None
None
1.48A 1xr2B-2xtzA:
1.7
1xr2B-2xtzA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 LYS A1248
THR A 209
SER A  70
ARG A 226
ALF  A 501 (-2.1A)
None
ADP  A 502 (-2.9A)
None
1.08A 1xr2B-3cmuA:
undetectable
1xr2B-3cmuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 LYS A2248
THR A1209
SER A1070
ARG A1226
ALF  A1501 (-2.3A)
None
ADP  A1502 (-2.9A)
None
1.07A 1xr2B-3cmuA:
undetectable
1xr2B-3cmuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 LYS A3248
THR A2209
SER A2070
ARG A2226
ALF  A2501 (-2.2A)
None
ADP  A2502 (-2.6A)
None
1.08A 1xr2B-3cmuA:
undetectable
1xr2B-3cmuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 LYS A4248
THR A3209
SER A3070
ARG A3226
ALF  A3501 (-2.3A)
None
ADP  A3502 (-2.7A)
None
1.06A 1xr2B-3cmuA:
undetectable
1xr2B-3cmuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
4 LYS A5248
THR A4209
SER A4070
ARG A4226
ALF  A4501 (-2.6A)
None
ADP  A4502 (-2.7A)
None
1.07A 1xr2B-3cmuA:
undetectable
1xr2B-3cmuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2


(Pseudomonas
aeruginosa)
PF03976
(PPK2)
4 LYS A 311
TRP A 408
SER A 364
ARG A 363
GOL  A 610 (-4.9A)
None
None
None
1.25A 1xr2B-3czpA:
undetectable
1xr2B-3czpA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus)
PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 LYS A 741
THR A 611
SER A 806
GLU A 849
MN  A2002 (-3.1A)
None
None
None
1.31A 1xr2B-3ho8A:
9.2
1xr2B-3ho8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6


(Homo sapiens)
PF02373
(JmjC)
4 LYS A 100
THR A 193
SER A 135
GLU A 103
SO4  A 343 ( 4.7A)
None
SO4  A 343 ( 4.9A)
None
1.31A 1xr2B-3ld8A:
undetectable
1xr2B-3ld8A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nib TEG14

(uncultured soil
bacterium)
PF00685
(Sulfotransfer_1)
4 LYS A  65
SER A   9
ARG A  90
GLU A  43
None
None
GOL  A 278 (-3.4A)
None
1.39A 1xr2B-3nibA:
undetectable
1xr2B-3nibA:
17.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE


(Candida
albicans)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
4 LYS A  19
TRP A 523
SER A 526
GLU A 620
None
0.90A 1xr2B-3ppcA:
48.8
1xr2B-3ppcA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE


(Candida
albicans)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
4 LYS A  19
TRP A 523
SER A 526
TRP A 576
None
0.59A 1xr2B-3ppcA:
48.8
1xr2B-3ppcA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbk RIG-I HELICASE
DOMAIN


(Mus musculus)
PF00271
(Helicase_C)
PF04851
(ResIII)
4 LYS A 611
LYS A 751
THR A 507
SER A 745
None
1.21A 1xr2B-3tbkA:
undetectable
1xr2B-3tbkA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL


(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
4 LYS A1460
THR A1528
SER A1166
GLU A1543
ACR  A   1 ( 3.7A)
ACR  A   1 ( 4.6A)
None
None
1.42A 1xr2B-3topA:
8.0
1xr2B-3topA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum)
PF00696
(AA_kinase)
PF01842
(ACT)
4 LYS A 294
SER A 238
ARG A 235
GLU A 343
None
1.16A 1xr2B-3tviA:
3.5
1xr2B-3tviA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
4 THR A 197
SER A 491
ARG A 139
GLU A 145
None
1.44A 1xr2B-3u4aA:
4.6
1xr2B-3u4aA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN


(Deinococcus
radiodurans)
PF13419
(HAD_2)
4 LYS A 146
THR A  88
SER A 113
GLU A 170
CIT  A 301 (-2.8A)
None
CIT  A 301 (-3.3A)
CIT  A 301 ( 4.5A)
1.30A 1xr2B-4eelA:
undetectable
1xr2B-4eelA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora)
PF02171
(Piwi)
4 LYS A 432
SER A 336
ARG A 325
GLU A 341
None
1.25A 1xr2B-4f1nA:
3.5
1xr2B-4f1nA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kr9 PROBABLE TRNA
SULFURTRANSFERASE


(Thermotoga
maritima)
PF02568
(ThiI)
PF02926
(THUMP)
4 LYS A  60
THR A 332
SER A 231
GLU A 202
None
1.43A 1xr2B-4kr9A:
undetectable
1xr2B-4kr9A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5o POLYMERASE PA

(Influenza A
virus)
PF00603
(Flu_PA)
4 TRP A 188
SER A 194
ARG A 125
GLU A  26
None
EDO  A 305 (-4.0A)
None
X48  A 308 (-3.5A)
1.02A 1xr2B-4m5oA:
undetectable
1xr2B-4m5oA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Methanocaldococcus
jannaschii)
PF02350
(Epimerase_2)
4 THR A  96
SER A 122
ARG A 311
GLU A 157
UD1  A 400 (-4.1A)
None
None
None
1.49A 1xr2B-4nesA:
2.6
1xr2B-4nesA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE


(Geobacillus
stearothermophilus)
PF16499
(Melibiase_2)
4 THR A 319
TRP A 340
TRP A 260
GLU A 390
None
1.49A 1xr2B-4nxkA:
undetectable
1xr2B-4nxkA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1
ECU04_1440 PROTEIN


(Encephalitozoon
cuniculi;
Encephalitozoon
cuniculi)
no annotation
PF00352
(TBP)
4 LYS D  41
LYS C 168
SER C  91
GLU C 144
None
1.30A 1xr2B-4wzsD:
undetectable
1xr2B-4wzsD:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4l CELLOBIOSE
2-EPIMERASE


(Caldicellulosiruptor
saccharolyticus)
PF07221
(GlcNAc_2-epim)
4 THR A 185
TRP A  98
SER A  55
ARG A  56
None
1.24A 1xr2B-4z4lA:
undetectable
1xr2B-4z4lA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
4 THR A 207
SER A 476
ARG A 146
GLU A 152
None
None
None
BGC  A 802 ( 4.9A)
1.36A 1xr2B-4zo6A:
4.4
1xr2B-4zo6A:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE


(Neurospora
crassa)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
5 LYS A  19
LYS A 115
TRP A 518
SER A 521
GLU A 615
None
1.37A 1xr2B-4ztxA:
51.5
1xr2B-4ztxA:
40.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE


(Neurospora
crassa)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
5 LYS A  19
LYS A 115
TRP A 518
SER A 521
TRP A 571
None
0.98A 1xr2B-4ztxA:
51.5
1xr2B-4ztxA:
40.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens)
PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED)
4 LYS A 376
LYS A 472
ARG A 369
GLU A 468
None
1.47A 1xr2B-5a3fA:
undetectable
1xr2B-5a3fA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus)
PF04196
(Bunya_RdRp)
PF15518
(L_protein_N)
4 THR A 811
SER A 233
ARG A 235
GLU A 224
None
1.25A 1xr2B-5amqA:
undetectable
1xr2B-5amqA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2


(Mus musculus)
PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12)
4 LYS A 357
SER A  88
ARG A  84
GLU A 354
None
1.43A 1xr2B-5eawA:
undetectable
1xr2B-5eawA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyw TRIOSEPHOSPHATE
ISOMERASE


(Litopenaeus
vannamei)
PF00121
(TIM)
4 LYS A  14
THR A 176
SER A  97
GLU A 133
PGA  A 301 (-2.7A)
None
None
None
1.30A 1xr2B-5eywA:
3.6
1xr2B-5eywA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA


(Methylobacillus
flagellatus)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
4 LYS C 174
THR C  50
SER C 238
GLU C 281
MN  C2002 ( 2.7A)
None
None
None
1.23A 1xr2B-5ks8C:
2.3
1xr2B-5ks8C:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN


(Bacteroides
intestinalis)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
4 THR A 229
SER A 528
ARG A 167
GLU A 173
None
1.35A 1xr2B-5tf0A:
undetectable
1xr2B-5tf0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis)
PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 LYS A 703
THR A 573
SER A 767
GLU A 810
MN  A1201 (-3.1A)
None
None
None
1.34A 1xr2B-5vywA:
undetectable
1xr2B-5vywA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wkn NUCLEOPROTEIN

(Mammalian
rubulavirus 5)
no annotation 4 LYS A 225
SER A  67
ARG A  69
GLU A 126
None
1.32A 1xr2B-5wknA:
undetectable
1xr2B-5wknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq8 TYPE II SECRETION
SYSTEM PROTEIN D


(Vibrio cholerae)
PF00263
(Secretin)
PF03958
(Secretin_N)
4 LYS A 483
THR A 460
ARG A 477
GLU A 503
None
1.37A 1xr2B-5wq8A:
undetectable
1xr2B-5wq8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzb CYCLIC GMP-AMP
SYNTHASE


(Mus musculus)
PF03281
(Mab-21)
4 LYS A 409
THR A 295
SER A 420
GLU A 371
None
1.41A 1xr2B-5xzbA:
undetectable
1xr2B-5xzbA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y81 TRANSCRIPTION-ASSOCI
ATED PROTEIN 1


(Saccharomyces
cerevisiae)
no annotation 4 THR B2836
ARG B3439
TRP B3542
GLU B2641
None
1.16A 1xr2B-5y81B:
undetectable
1xr2B-5y81B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zib -

(-)
no annotation 4 LYS A 337
SER A 169
ARG A 168
GLU A 193
None
1.32A 1xr2B-5zibA:
undetectable
1xr2B-5zibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C


(Flavobacterium
johnsoniae)
no annotation 4 THR C 277
TRP C  85
SER C 122
GLU C 116
None
1.43A 1xr2B-6btmC:
undetectable
1xr2B-6btmC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2


(Candidatus
Methanoperedens
nitroreducens)
no annotation 4 LYS A  32
THR A 233
SER A  53
GLU A  29
None
1.10A 1xr2B-6bxnA:
undetectable
1xr2B-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5b METHYLTRANSFERASE

(Lysobacter
antibioticus)
no annotation 4 THR A 127
SER A 258
ARG A 257
GLU A 311
None
1.12A 1xr2B-6c5bA:
undetectable
1xr2B-6c5bA:
undetectable