SIMILAR PATTERNS OF AMINO ACIDS FOR 1XR2_A_C2FA1200_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 ARG A  15
LYS A  18
SER A 517
CYH A 522
GLU A 611
 None
 0.83A 1xr2A-1u1hA:
47.5		 1xr2A-1u1hA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 ARG A  15
LYS A  18
SER A 517
CYH A 522
TRP A 567
 None
 0.51A 1xr2A-1u1hA:
47.5		 1xr2A-1u1hA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		9 ARG A  15
LYS A  18
LYS A 104
SER A 489
ARG A 493
CYH A 494
TRP A 539
PRO A 579
GLU A 583
 C2F  A1882 ( 4.6A)
C2F  A1882 (-2.4A)
C2F  A1882 ( 3.3A)
C2F  A1882 (-3.0A)
C2F  A1882 ( 3.5A)
C2F  A1882 (-4.6A)
C2F  A1882 (-3.7A)
None
C2F  A1882 (-3.0A)
 0.47A 1xr2A-1xpgA:
65.4		 1xr2A-1xpgA:
99.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 ARG A  16
LYS A  19
SER A 526
PRO A 616
GLU A 620
 None
 0.96A 1xr2A-3ppcA:
48.9		 1xr2A-3ppcA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		7 ARG A  16
LYS A  19
LYS A 115
SER A 521
CYH A 526
PRO A 611
GLU A 615
 None
 0.99A 1xr2A-4ztxA:
50.2		 1xr2A-4ztxA:
40.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		7 ARG A  16
LYS A  19
LYS A 115
SER A 521
CYH A 526
TRP A 571
PRO A 611
 None
 0.84A 1xr2A-4ztxA:
50.2		 1xr2A-4ztxA:
40.67