SIMILAR PATTERNS OF AMINO ACIDS FOR 1XPQ_D_SPMD922

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg8 PROTEIN (HEMOGLOBIN)

(Dasyatis akajei) 		PF00042
(Globin) 		5 TRP B  15
ASP B  72
LEU B 109
PHE B 128
TYR B 113
 None
 1.43A 1xpqD-1cg8B:
undetectable		 1xpqD-1cg8B:
14.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		5 HIS A 191
ASN A 195
LEU A 171
LYS A 312
PHE A  97
 None
 1.39A 1xpqD-1yy5A:
57.9		 1xpqD-1yy5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		6 HIS A 191
ASP A  94
PHE A  97
ASN A 195
LYS A 312
PHE A 359
 None
 1.43A 1xpqD-1yy5A:
57.9		 1xpqD-1yy5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		9 TRP A  65
HIS A  67
ASP A  94
PHE A  97
ASN A 195
LEU A 294
LYS A 312
PHE A 359
TYR A 450
 None
FAD  A 803 (-3.8A)
None
None
None
FAD  A 803 (-4.5A)
None
None
FAD  A 803 (-4.6A)
 0.41A 1xpqD-1yy5A:
57.9		 1xpqD-1yy5A:
100.00