SIMILAR PATTERNS OF AMINO ACIDS FOR 1XPQ_C_SPMC921

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		7 TRP A  65
ASP A  94
TRP A 174
LEU A 294
LYS A 312
LEU A 375
TYR A 450
 None
None
None
FAD  A 803 (-4.5A)
None
None
FAD  A 803 (-4.6A)
 1.30A 1xpqC-1yy5A:
58.6		 1xpqC-1yy5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		10 TRP A  65
HIS A  67
ASP A  94
ASN A 195
LEU A 294
LYS A 312
PHE A 359
LEU A 375
TYR A 450
CYH A 488
 None
FAD  A 803 (-3.8A)
None
None
FAD  A 803 (-4.5A)
None
None
None
FAD  A 803 (-4.6A)
FAD  A 803 (-4.0A)
 0.32A 1xpqC-1yy5A:
58.6		 1xpqC-1yy5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 TRP A 549
ASP A 220
LEU A 629
PHE A 621
LEU A 625
 None
 1.17A 1xpqC-2ivfA:
0.9		 1xpqC-2ivfA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 TRP A 549
LEU A 629
LYS A 614
PHE A 621
LEU A 625
 None
 1.30A 1xpqC-2ivfA:
0.9		 1xpqC-2ivfA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzb AUTOPHAGY-RELATED
PROTEIN 19

(Saccharomyces
cerevisiae) 		PF12744
(ATG19_autophagy) 		5 ASN A 339
LEU A 277
PHE A 346
LEU A 262
TYR A 320
 None
 1.49A 1xpqC-2kzbA:
0.0		 1xpqC-2kzbA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		5 ASN A 232
LEU A 286
LEU A 249
TYR A 301
CYH A 302
 GLC  A 600 (-2.7A)
None
None
None
None
 1.32A 1xpqC-2osyA:
0.0		 1xpqC-2osyA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY

(Burkholderia
thailandensis) 		PF02636
(Methyltransf_28) 		5 ASP A 276
LEU A 133
PHE A  99
LEU A 103
TYR A 147
 None
None
EDO  A 503 (-3.5A)
None
None
 1.16A 1xpqC-4f3nA:
0.8		 1xpqC-4f3nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9u CG32412

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		5 ASP A  80
ASN A  96
LEU A 216
PHE A 277
LEU A 214
 None
 1.30A 1xpqC-4f9uA:
0.0		 1xpqC-4f9uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 ASP A 107
ASN A 122
LEU A 246
PHE A 310
LEU A 244
 None
 1.41A 1xpqC-4yu9A:
0.0		 1xpqC-4yu9A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 ASP A 297
ASN A 300
LEU A 346
LYS A 360
LEU A 340
 None
 1.31A 1xpqC-4ztxA:
0.0		 1xpqC-4ztxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dp1 CURK

(Moorea
producens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ASN A 228
LEU A  55
LYS A 324
PHE A  45
LEU A  49
 None
 1.48A 1xpqC-5dp1A:
0.7		 1xpqC-5dp1A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3e CDII IMMUNITY
PROTEIN

(Yersinia
kristensenii) 		no annotation 5 TRP A  89
ASP A  30
LEU A  10
PHE A  18
LEU A  14
 None
 1.08A 1xpqC-5e3eA:
undetectable		 1xpqC-5e3eA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35

(Homo sapiens) 		PF03635
(Vps35) 		5 ASN A  37
LYS A  90
PHE A  85
LEU A  81
TYR A  76
 None
SO4  A 507 ( 3.5A)
None
None
GOL  A 506 (-3.5A)
 1.47A 1xpqC-5f0kA:
undetectable		 1xpqC-5f0kA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		5 ASN A1073
LEU A1098
LYS A1148
PHE A1106
LEU A1102
 None
 1.41A 1xpqC-5ffjA:
1.5		 1xpqC-5ffjA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC
SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ASP A 328
ASN B 298
LEU B 315
LEU B 289
CYH B 328
 None
 1.43A 1xpqC-5l3rA:
undetectable		 1xpqC-5l3rA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		5 ASP A1759
LEU A1082
PHE A1609
LEU A1613
TYR A1081
 None
 1.33A 1xpqC-5lkiA:
undetectable		 1xpqC-5lkiA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 ASN A 235
LEU A 200
PHE A 224
LEU A 220
TYR A 156
 None
 1.50A 1xpqC-5ur2A:
undetectable		 1xpqC-5ur2A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 ASP A 452
LEU A 547
PHE A 456
LEU A 551
TYR A 524
 None
 1.33A 1xpqC-6c0tA:
0.8		 1xpqC-6c0tA:
9.80