SIMILAR PATTERNS OF AMINO ACIDS FOR 1XPQ_A_SPMA924

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7s FERRICHROME-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		5 PHE N 238
LEU N 131
PHE N 197
LEU N 196
TYR N 158
 None
 1.43A 1xpqA-1k7sN:
2.2		 1xpqA-1k7sN:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		6 HIS A  67
ASP A  93
LEU A 294
PHE A 359
TYR A 450
CYH A 488
 FAD  A 803 (-3.8A)
None
FAD  A 803 (-4.5A)
None
FAD  A 803 (-4.6A)
FAD  A 803 (-4.0A)
 1.50A 1xpqA-1yy5A:
58.4		 1xpqA-1yy5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		6 TRP A  65
ASP A  94
TRP A 174
LEU A 294
LEU A 375
TYR A 450
 None
None
None
FAD  A 803 (-4.5A)
None
FAD  A 803 (-4.6A)
 1.38A 1xpqA-1yy5A:
58.4		 1xpqA-1yy5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		10 TRP A  65
HIS A  67
ASP A  94
PHE A  97
ASN A 195
LEU A 294
PHE A 359
LEU A 375
TYR A 450
CYH A 488
 None
FAD  A 803 (-3.8A)
None
None
None
FAD  A 803 (-4.5A)
None
None
FAD  A 803 (-4.6A)
FAD  A 803 (-4.0A)
 0.34A 1xpqA-1yy5A:
58.4		 1xpqA-1yy5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 TRP A 549
ASP A 220
LEU A 629
PHE A 621
LEU A 625
 None
 1.06A 1xpqA-2ivfA:
1.0		 1xpqA-2ivfA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oez UPF0289 PROTEIN
VP2528

(Vibrio
parahaemolyticus) 		PF07072
(ZapD) 		5 PHE A  33
ASN A 154
LEU A 111
PHE A  42
LEU A  46
 None
 1.43A 1xpqA-2oezA:
0.0		 1xpqA-2oezA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		5 ASP A  96
PHE A 278
LEU A 341
PHE A 622
CYH A 310
 None
 1.46A 1xpqA-3gyxA:
13.7		 1xpqA-3gyxA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmd S-M CHECKPOINT
CONTROL PROTEIN RAD4

(Schizosaccharomyces
pombe) 		PF00533
(BRCT)
PF16589
(BRCT_2) 		5 ASN A 363
LEU A 325
PHE A 313
LEU A 321
CYH A 370
 None
 1.41A 1xpqA-4bmdA:
0.0		 1xpqA-4bmdA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1

(Mus musculus) 		PF08447
(PAS_3) 		5 TRP A 441
PHE A 360
LEU A 394
PHE A 427
LEU A 397
 None
 1.41A 1xpqA-4dj2A:
0.0		 1xpqA-4dj2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9u CG32412

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		5 ASP A  80
ASN A  96
LEU A 216
PHE A 277
LEU A 214
 None
 1.30A 1xpqA-4f9uA:
1.1		 1xpqA-4f9uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 ASP A 107
ASN A 122
LEU A 246
PHE A 310
LEU A 244
 None
 1.40A 1xpqA-4yu9A:
0.0		 1xpqA-4yu9A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3e CDII IMMUNITY
PROTEIN

(Yersinia
kristensenii) 		no annotation 5 TRP A  89
ASP A  30
LEU A  10
PHE A  18
LEU A  14
 None
 1.07A 1xpqA-5e3eA:
undetectable		 1xpqA-5e3eA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		5 ASP A1759
LEU A1082
PHE A1609
LEU A1613
TYR A1081
 None
 1.26A 1xpqA-5lkiA:
0.0		 1xpqA-5lkiA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 ASN A 235
LEU A 200
PHE A 224
LEU A 220
TYR A 156
 None
 1.48A 1xpqA-5ur2A:
undetectable		 1xpqA-5ur2A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 ASP A 452
LEU A 547
PHE A 456
LEU A 551
TYR A 524
 None
 1.40A 1xpqA-6c0tA:
0.5		 1xpqA-6c0tA:
9.80