SIMILAR PATTERNS OF AMINO ACIDS FOR 1XPG_B_C2FB1883_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		6 ARG A  15
LYS A  18
TRP A 514
SER A 517
CYH A 522
TRP A 567
 None
 0.45A 1xpgB-1u1hA:
48.8		 1xpgB-1u1hA:
41.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		10 ARG A  15
LYS A  18
LYS A 104
THR A 466
TRP A 486
SER A 489
ARG A 493
CYH A 494
TRP A 539
GLU A 583
 C2F  A1882 ( 4.6A)
C2F  A1882 (-2.4A)
C2F  A1882 ( 3.3A)
None
None
C2F  A1882 (-3.0A)
C2F  A1882 ( 3.5A)
C2F  A1882 (-4.6A)
C2F  A1882 (-3.7A)
C2F  A1882 (-3.0A)
 0.47A 1xpgB-1xpgA:
65.6		 1xpgB-1xpgA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 ARG A  16
LYS A  19
TRP A 497
ARG A 504
TRP A 550
 None
 0.87A 1xpgB-2nq5A:
50.4		 1xpgB-2nq5A:
43.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 ARG A  16
TRP A 497
SER A 500
ARG A 504
TRP A 550
 None
 1.03A 1xpgB-2nq5A:
50.4		 1xpgB-2nq5A:
43.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		6 ARG A  16
LYS A  19
TRP A 523
SER A 526
TRP A 576
GLU A 620
 None
 0.88A 1xpgB-3ppcA:
49.6		 1xpgB-3ppcA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		7 ARG A  16
LYS A  19
LYS A 115
TRP A 518
SER A 521
CYH A 526
TRP A 571
 None
 0.84A 1xpgB-4ztxA:
52.8		 1xpgB-4ztxA:
40.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		7 LYS A  19
LYS A 115
TRP A 518
SER A 521
CYH A 526
TRP A 571
GLU A 615
 None
 1.17A 1xpgB-4ztxA:
52.8		 1xpgB-4ztxA:
40.84