SIMILAR PATTERNS OF AMINO ACIDS FOR 1XPG_A_C2FA1882_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  18
ASN A 116
SER A 517
CYH A 522
TRP A 567
 None
 0.44A 1xpgA-1u1hA:
48.4		 1xpgA-1u1hA:
41.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		9 LYS A  18
LYS A 104
ASN A 109
ASP A 467
SER A 489
ARG A 493
CYH A 494
TRP A 539
GLU A 583
 C2F  A1882 (-2.4A)
C2F  A1882 ( 3.3A)
C2F  A1882 (-3.7A)
C2F  A1882 ( 4.9A)
C2F  A1882 (-3.0A)
C2F  A1882 ( 3.5A)
C2F  A1882 (-4.6A)
C2F  A1882 (-3.7A)
C2F  A1882 (-3.0A)
 0.06A 1xpgA-1xpgA:
68.9		 1xpgA-1xpgA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  19
ASN A 126
ASP A 504
SER A 526
GLU A 620
 None
 0.79A 1xpgA-3ppcA:
49.7		 1xpgA-3ppcA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		6 LYS A  19
LYS A 115
ASP A 499
SER A 521
CYH A 526
GLU A 615
 None
 1.10A 1xpgA-4ztxA:
52.1		 1xpgA-4ztxA:
40.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LYS A  19
LYS A 115
SER A 521
CYH A 526
TRP A 571
 None
 0.82A 1xpgA-4ztxA:
52.1		 1xpgA-4ztxA:
40.84