SIMILAR PATTERNS OF AMINO ACIDS FOR 1XP0_A_VDNA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		5 LEU A 247
ALA A 249
ILE A 251
VAL A 220
ALA A 196
 None
None
None
8IG  A 306 (-4.6A)
None
 1.18A 1xp0A-1c3xA:
undetectable		 1xp0A-1c3xA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 258
ALA A   8
ILE A   7
VAL A  38
ALA A  37
 None
None
None
None
SO4  A 811 ( 4.0A)
 1.08A 1xp0A-1dm3A:
0.0		 1xp0A-1dm3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE

(Thermococcus
profundus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LEU A 230
ALA A 195
ILE A 196
VAL A 217
ALA A 216
 None
 1.19A 1xp0A-1euzA:
0.0		 1xp0A-1euzA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7y STEM/LEAF LECTIN
DB58

(Vigna
unguiculata) 		PF00139
(Lectin_legB) 		5 LEU A 179
ILE A 164
VAL A 122
ALA A 121
LEU A 105
 None
 1.19A 1xp0A-1g7yA:
undetectable		 1xp0A-1g7yA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu2 LECTIN

(Vigna
unguiculata) 		PF00139
(Lectin_legB) 		5 LEU A 179
ILE A 164
VAL A 122
ALA A 121
LEU A 105
 None
 1.15A 1xp0A-1lu2A:
undetectable		 1xp0A-1lu2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		5 ALA A  44
ILE A  43
VAL A  36
ALA A  83
LEU A 109
 None
 1.00A 1xp0A-1toaA:
0.0		 1xp0A-1toaA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yoz HYPOTHETICAL PROTEIN
AF0941

(Archaeoglobus
fulgidus) 		PF14591
(AF0941-like) 		5 TYR A 116
LEU A  55
ILE A  54
ALA A 114
PHE A  72
 None
 1.06A 1xp0A-1yozA:
undetectable		 1xp0A-1yozA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zan FAB AD11 HEAVY CHAIN
FAB AD11 LIGHT CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR L  71
ALA L  25
ILE L   2
ALA L  34
LEU H 100
 None
 1.10A 1xp0A-1zanL:
undetectable		 1xp0A-1zanL:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 211
VAL A 380
LEU A 401
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.85A 1xp0A-1zklA:
38.6		 1xp0A-1zklA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2auw HYPOTHETICAL PROTEIN
NE0471

(Nitrosomonas
europaea) 		PF10387
(DUF2442) 		5 LEU A  38
ILE A  37
VAL A  32
ALA A  81
PHE A  72
 None
GOL  A1202 (-3.4A)
None
None
None
 1.04A 1xp0A-2auwA:
undetectable		 1xp0A-2auwA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfr HYPOTHETICAL PROTEIN
AF1521

(Archaeoglobus
fulgidus) 		PF01661
(Macro) 		5 LEU A 124
ALA A 127
ILE A 135
VAL A  80
PHE A 137
 None
 1.13A 1xp0A-2bfrA:
0.4		 1xp0A-2bfrA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyk GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1) 		5 LEU A 153
ALA A 155
ILE A 156
VAL A 114
ALA A  86
 None
 1.03A 1xp0A-2dykA:
undetectable		 1xp0A-2dykA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF01230
(HIT) 		5 LEU A  37
ALA A  24
ILE A  39
VAL A  62
ALA A  59
 None
 1.12A 1xp0A-2eo4A:
undetectable		 1xp0A-2eo4A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8v PHYCOBILISOME 32.1
KDA LINKER
POLYPEPTIDE,
PHYCOCYANIN-ASSOCIAT
ED, ROD

(Thermosynechococcus
elongatus) 		PF00427
(PBS_linker_poly) 		5 LEU A  44
ALA A  40
ILE A  49
VAL A  58
ALA A  59
 None
 1.20A 1xp0A-2l8vA:
0.0		 1xp0A-2l8vA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfm ADENYLOSUCCINATE
LYASE

(Bacillus
anthracis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 TYR A 224
LEU A 322
ALA A 318
ILE A 286
ALA A 222
 None
 1.19A 1xp0A-2pfmA:
undetectable		 1xp0A-2pfmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rc5 FERREDOXIN-NADP
REDUCTASE

(Leptospira
interrogans) 		PF00175
(NAD_binding_1) 		5 LEU A 263
ALA A 258
ILE A 262
VAL A 252
PHE A 269
 None
 1.08A 1xp0A-2rc5A:
undetectable		 1xp0A-2rc5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjt ALLOPHYCOCYANIN BETA
SUBUNIT

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		5 TYR B  12
LEU B  24
ALA B  22
VAL B   8
ALA B   7
 None
 0.95A 1xp0A-2vjtB:
undetectable		 1xp0A-2vjtB:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		5 LEU A 130
ALA A 132
ILE A 133
VAL A 166
ALA A 167
 None
 1.17A 1xp0A-2vn7A:
1.7		 1xp0A-2vn7A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 ALA A 221
VAL A 196
ALA A 193
LEU A 258
PHE A 226
 None
 1.19A 1xp0A-2wdaA:
undetectable		 1xp0A-2wdaA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 TYR A  20
LEU A  64
ILE A  30
ALA A  18
PHE A   8
 None
 1.14A 1xp0A-2xf8A:
undetectable		 1xp0A-2xf8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 LEU D 349
ALA D 348
VAL D 308
ALA D 311
PHE D 300
 None
 1.18A 1xp0A-2ynmD:
undetectable		 1xp0A-2ynmD:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		5 LEU B 333
ALA B 332
VAL B 292
ALA B 295
PHE B 284
 None
 1.17A 1xp0A-3aeqB:
undetectable		 1xp0A-3aeqB:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		9 TYR A 612
LEU A 765
ALA A 767
ILE A 768
VAL A 782
ALA A 783
MET A 816
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 ( 4.7A)
VDN  A   1 ( 3.8A)
VDN  A   1 (-4.5A)
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.0A)
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.28A 1xp0A-3b2rA:
45.9		 1xp0A-3b2rA:
94.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 ALA A 214
ILE A 215
VAL A 167
ALA A 166
PHE A 344
 None
 1.10A 1xp0A-3bc9A:
undetectable		 1xp0A-3bc9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 LEU A 211
ILE A 215
VAL A 167
ALA A 166
PHE A 344
 None
 1.10A 1xp0A-3bc9A:
undetectable		 1xp0A-3bc9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjb PROBABLE
TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		5 LEU A  26
ALA A  28
VAL A  52
ALA A  53
PHE A  61
 None
None
SO4  A 320 ( 4.0A)
SO4  A 320 (-3.7A)
None
 1.02A 1xp0A-3bjbA:
undetectable		 1xp0A-3bjbA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		9 TYR A 612
LEU A 765
ALA A 767
ILE A 768
VAL A 782
ALA A 783
MET A 816
GLN A 817
PHE A 820
 None
WAN  A 901 ( 4.7A)
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.6A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.35A 1xp0A-3bjcA:
48.5		 1xp0A-3bjcA:
46.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cij UPF0100 PROTEIN
AF_0094

(Archaeoglobus
fulgidus) 		PF13531
(SBP_bac_11) 		5 LEU A 160
ALA A 162
ILE A 163
ALA A 118
LEU A 230
 None
 1.02A 1xp0A-3cijA:
undetectable		 1xp0A-3cijA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpi NAD+ SYNTHETASE

(Burkholderia
pseudomallei) 		PF02540
(NAD_synthase) 		5 TYR A  88
LEU A 122
ALA A 118
ILE A 145
ALA A 220
 None
 1.10A 1xp0A-3dpiA:
undetectable		 1xp0A-3dpiA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3el6 ERYTHROMYCIN
DEHYDRATASE

(Saccharopolyspora
erythraea) 		PF14765
(PS-DH) 		5 LEU A  15
ALA A  64
VAL A 108
ALA A 126
LEU A  82
 None
 1.10A 1xp0A-3el6A:
undetectable		 1xp0A-3el6A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		5 TYR A 141
ILE A  73
VAL A 137
MET A  99
PHE A 101
 None
 1.16A 1xp0A-3g7uA:
undetectable		 1xp0A-3g7uA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcy PUTATIVE
TWO-COMPONENT SENSOR
HISTIDINE KINASE
PROTEIN

(Sinorhizobium
meliloti) 		PF13185
(GAF_2) 		5 ALA A  11
ILE A 126
ALA A  36
LEU A  24
PHE A 105
 None
 1.16A 1xp0A-3hcyA:
undetectable		 1xp0A-3hcyA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl1 FERRITIN LIKE
PROTEIN

(Caulobacter
vibrioides) 		PF12902
(Ferritin-like) 		5 LEU A 279
ILE A 278
ALA A 270
LEU A 268
PHE A 275
 None
 1.17A 1xp0A-3hl1A:
undetectable		 1xp0A-3hl1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iie 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Yersinia
pseudotuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 LEU A 111
ALA A 113
ILE A 114
ALA A 123
PHE A 135
 None
 1.20A 1xp0A-3iieA:
undetectable		 1xp0A-3iieA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 LEU A 392
ALA A 396
VAL A 410
ALA A 463
PHE A 444
 None
 0.91A 1xp0A-3k1dA:
undetectable		 1xp0A-3k1dA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg4 UNCHARACTERIZED
PROTEIN

([Mannheimia]
succiniciproducens) 		PF09704
(Cas_Cas5d) 		5 LEU A   7
ALA A 118
ILE A   5
MET A 138
PHE A 139
 None
 0.98A 1xp0A-3kg4A:
undetectable		 1xp0A-3kg4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		5 LEU A 139
ALA A 135
ILE A 138
VAL A  34
ALA A  31
 None
 1.16A 1xp0A-3ll8A:
undetectable		 1xp0A-3ll8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		5 ALA A 287
ILE A 291
VAL A  37
ALA A  38
LEU A  55
 None
 1.20A 1xp0A-3lpdA:
undetectable		 1xp0A-3lpdA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ALA A  21
ILE A  20
VAL A   8
ALA A  85
LEU A 115
 None
 1.04A 1xp0A-3mogA:
undetectable		 1xp0A-3mogA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa0 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WBPB

(Thermus
thermophilus) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A  61
ALA A  90
ALA A  77
LEU A   9
PHE A  57
 None
None
NAD  A 311 (-4.5A)
None
None
 1.19A 1xp0A-3oa0A:
undetectable		 1xp0A-3oa0A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		5 LEU A 321
ALA A 285
ALA A 337
LEU A 264
PHE A 313
 None
None
GOL  A 500 ( 3.8A)
None
None
 1.15A 1xp0A-3oepA:
undetectable		 1xp0A-3oepA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7n SENSOR HISTIDINE
KINASE

(Erythrobacter
litoralis) 		PF00196
(GerE)
PF13426
(PAS_9) 		5 LEU A  52
ALA A  54
ILE A  55
ALA A 211
LEU A 120
 None
 1.16A 1xp0A-3p7nA:
undetectable		 1xp0A-3p7nA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Mus musculus) 		PF04389
(Peptidase_M28) 		5 LEU A 272
ALA A 274
ILE A 275
ALA A  47
LEU A 360
 None
 0.86A 1xp0A-3si1A:
undetectable		 1xp0A-3si1A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		5 LEU A 200
ALA A 202
ILE A 203
VAL A 167
PHE A 188
 None
None
None
SAH  A 258 (-3.6A)
None
 0.99A 1xp0A-3tosA:
undetectable		 1xp0A-3tosA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4y UNCHARACTERIZED
PROTEIN

(Desulfotomaculum
acetoxidans) 		PF10282
(Lactonase) 		5 ALA A 127
ILE A 123
ALA A 131
LEU A 139
PHE A 153
 None
 1.16A 1xp0A-3u4yA:
undetectable		 1xp0A-3u4yA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uki OXYR

(Porphyromonas
gingivalis) 		PF03466
(LysR_substrate) 		5 LEU A 105
ALA A 102
ILE A 101
VAL A 124
LEU A  93
 None
 1.17A 1xp0A-3ukiA:
undetectable		 1xp0A-3ukiA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnv GLYOXYLATE REDUCTASE

(Paecilomyces
sp.
'thermophila') 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 100
ILE A  72
VAL A  79
ALA A  53
LEU A   7
 None
 1.06A 1xp0A-3wnvA:
undetectable		 1xp0A-3wnvA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ajv TRANSFORMING GROWTH
FACTOR BETA RECEPTOR
TYPE 3

(Mus musculus) 		PF00100
(Zona_pellucida) 		5 LEU A 702
ILE A 640
VAL A 612
ALA A 613
PHE A 689
 None
 1.04A 1xp0A-4ajvA:
undetectable		 1xp0A-4ajvA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blp PACKAGING ENZYME P4

(Pseudomonas
phage phi13) 		PF11602
(NTPase_P4) 		5 LEU A 203
ALA A  86
VAL A 109
ALA A 108
PHE A  99
 None
 1.14A 1xp0A-4blpA:
undetectable		 1xp0A-4blpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxj AMPDH3

(Pseudomonas
aeruginosa) 		PF01510
(Amidase_2) 		5 LEU A 246
ALA A 244
ILE A 245
ALA A 237
PHE A 225
 None
 1.20A 1xp0A-4bxjA:
undetectable		 1xp0A-4bxjA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bza TRANSLOCATION AND
ASSEMBLY MODULE TAMA

(Escherichia
coli) 		PF07244
(POTRA)
PF17243
(POTRA_TamA_1) 		5 LEU A 105
ALA A 177
ILE A 106
ALA A  71
LEU A  35
 None
 1.14A 1xp0A-4bzaA:
undetectable		 1xp0A-4bzaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8g 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Burkholderia
cenocepacia) 		PF02542
(YgbB) 		5 LEU A  43
ALA A  45
ILE A  46
VAL A 100
ALA A 133
 None
None
None
None
C5P  A1163 (-3.6A)
 1.04A 1xp0A-4c8gA:
undetectable		 1xp0A-4c8gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cza NA+/H+ ANTIPORTER,
PUTATIVE

(Pyrococcus
abyssi) 		PF00999
(Na_H_Exchanger) 		5 LEU A 250
ALA A 252
VAL A 257
ALA A 258
LEU A 239
 None
 1.17A 1xp0A-4czaA:
undetectable		 1xp0A-4czaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA

(Brucella
abortus) 		PF00677
(Lum_binding) 		6 LEU A  88
ALA A  42
ILE A  41
ALA A  67
LEU A  23
PHE A  63
 None
None
None
RBF  A 301 (-4.1A)
None
None
 1.48A 1xp0A-4e0fA:
undetectable		 1xp0A-4e0fA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc4 NITRITE TRANSPORTER
NIRC

(Salmonella
enterica) 		PF01226
(Form_Nir_trans) 		5 LEU A 204
ALA A 200
ILE A  42
ALA A 192
PHE A  46
 None
 0.86A 1xp0A-4fc4A:
undetectable		 1xp0A-4fc4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxx METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 LEU A 181
ALA A 185
ILE A 184
VAL A 158
ALA A 155
 None
 1.10A 1xp0A-4hxxA:
undetectable		 1xp0A-4hxxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		5 LEU A 472
ALA A 468
ILE A 471
VAL A 367
ALA A 364
 None
 1.15A 1xp0A-4il1A:
undetectable		 1xp0A-4il1A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu6 METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 LEU A 181
ALA A 185
ILE A 184
VAL A 158
ALA A 155
 None
 1.12A 1xp0A-4iu6A:
undetectable		 1xp0A-4iu6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj3 MAMP

(Magnetococcus
marinus) 		PF13180
(PDZ_2) 		5 LEU A 120
ALA A  99
ILE A 121
ALA A 141
LEU A 176
 None
 1.16A 1xp0A-4jj3A:
undetectable		 1xp0A-4jj3A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jot ENOYL-COA HYDRATASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF00378
(ECH_1) 		5 LEU A 124
ALA A 128
ILE A 125
ALA A 202
PHE A  65
 None
 1.15A 1xp0A-4jotA:
undetectable		 1xp0A-4jotA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE

(Acinetobacter
baumannii) 		PF00348
(polyprenyl_synt) 		5 LEU A 189
ALA A 187
ILE A 188
ALA A 203
LEU A 178
 None
 1.20A 1xp0A-4lobA:
2.2		 1xp0A-4lobA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		5 ALA A 420
ILE A 405
VAL A 459
ALA A 460
LEU A 375
 None
 1.17A 1xp0A-4nnbA:
undetectable		 1xp0A-4nnbA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orb SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Mus musculus) 		PF00149
(Metallophos) 		5 LEU A 139
ALA A 135
ILE A 138
VAL A  34
ALA A  31
 None
 1.10A 1xp0A-4orbA:
undetectable		 1xp0A-4orbA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		5 LEU A 156
ILE A 157
VAL A 189
ALA A 185
LEU A 180
 None
 1.15A 1xp0A-4otkA:
undetectable		 1xp0A-4otkA:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		5 LEU A 190
ILE A 189
VAL A 164
LEU A 298
PHE A 171
 None
 1.08A 1xp0A-4ovjA:
undetectable		 1xp0A-4ovjA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B

(Vibrio cholerae) 		PF03116
(NQR2_RnfD_RnfE) 		5 LEU B 168
ILE B 169
VAL B 136
ALA B 180
LEU B 176
 None
 1.17A 1xp0A-4p6vB:
undetectable		 1xp0A-4p6vB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase) 		5 TYR B 196
LEU B 175
ILE B 177
ALA B 250
LEU B 253
 None
 1.13A 1xp0A-4pelB:
undetectable		 1xp0A-4pelB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl5 EXOCYST COMPLEX
COMPONENT EXO70A1

(Arabidopsis
thaliana) 		PF03081
(Exo70) 		5 LEU A 469
ALA A 507
VAL A 584
ALA A 585
PHE A 628
 None
 1.15A 1xp0A-4rl5A:
undetectable		 1xp0A-4rl5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkj D-LACTATE
DEHYDROGENASE

(Sporolactobacillus
inulinus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ALA A 232
ILE A 230
VAL A 160
ALA A 161
LEU A 167
 NAD  A 401 (-4.7A)
None
None
None
None
 1.17A 1xp0A-4xkjA:
undetectable		 1xp0A-4xkjA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A 120
ILE A 118
VAL A 181
ALA A 221
LEU A 102
 FDA  A 402 (-3.3A)
FDA  A 402 (-4.9A)
None
None
None
 1.13A 1xp0A-4xvxA:
undetectable		 1xp0A-4xvxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 LEU A 271
ALA A 273
ILE A 274
ALA A  46
LEU A 359
 None
 0.95A 1xp0A-4yu9A:
undetectable		 1xp0A-4yu9A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 TYR A 239
ALA A 544
ILE A 539
ALA A 554
LEU A 519
 None
 1.12A 1xp0A-5agaA:
undetectable		 1xp0A-5agaA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b58 PUTATIVE HEMIN ABC
TRANSPORT SYSTEM,
MEMBRANE PROTEIN

(Burkholderia
cenocepacia) 		PF01032
(FecCD) 		5 ALA A 182
ILE A 181
VAL A 161
ALA A 158
LEU A 268
 None
 1.17A 1xp0A-5b58A:
undetectable		 1xp0A-5b58A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		5 LEU A 384
ALA A 382
ILE A 381
VAL A 319
ALA A 320
 None
 1.12A 1xp0A-5bq2A:
undetectable		 1xp0A-5bq2A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Haemophilus
influenzae) 		PF00005
(ABC_tran) 		5 LEU A 465
ALA A 464
ILE A 468
ALA A 443
PHE A 475
 None
 1.16A 1xp0A-5eumA:
undetectable		 1xp0A-5eumA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fby SEPARASE

(Chaetomium
thermophilum) 		PF03568
(Peptidase_C50) 		5 LEU A1719
ILE A1717
VAL A1979
ALA A1978
PHE A1827
 None
 1.05A 1xp0A-5fbyA:
undetectable		 1xp0A-5fbyA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 LEU A  29
ALA A  57
ILE A  56
ALA A 184
LEU A 141
 None
 1.09A 1xp0A-5fyaA:
undetectable		 1xp0A-5fyaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikl GERANYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		5 LEU B 124
ALA B 150
ILE B 119
ALA B 192
LEU B 197
 None
 1.17A 1xp0A-5iklB:
undetectable		 1xp0A-5iklB:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		5 ALA A 424
ILE A 409
VAL A 463
ALA A 464
LEU A 379
 None
 1.15A 1xp0A-5ikzA:
undetectable		 1xp0A-5ikzA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipy FLAVIN-CONTAINING
MONOOXYGENASE

(Roseovarius
nubinhibens) 		PF00743
(FMO-like) 		5 LEU A 337
ALA A 335
ILE A 336
GLN A  17
PHE A  21
 None
 1.16A 1xp0A-5ipyA:
undetectable		 1xp0A-5ipyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE

(Lactobacillus
acidophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU A  49
ILE A  69
VAL A  33
LEU A  99
PHE A  10
 None
 1.04A 1xp0A-5j9gA:
undetectable		 1xp0A-5j9gA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh8 PROBABLE CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		5 ALA A  50
ILE A  51
VAL A  26
ALA A  25
PHE A 103
 None
MLZ  A 101 ( 4.2A)
None
None
MLZ  A 101 ( 2.9A)
 1.03A 1xp0A-5jh8A:
undetectable		 1xp0A-5jh8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 356
ALA A 358
LEU A 319
MET A 373
PHE A 374
 None
 1.19A 1xp0A-5k13A:
3.1		 1xp0A-5k13A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE

(Plasmodium
falciparum) 		PF00027
(cNMP_binding) 		5 LEU A 251
ALA A 272
ILE A 236
ALA A 261
LEU A 263
 None
None
CMP  A 501 (-3.8A)
CMP  A 501 (-3.5A)
None
 1.20A 1xp0A-5kbfA:
undetectable		 1xp0A-5kbfA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 112
ALA A 160
ILE A 158
VAL A 167
ALA A 168
 None
 1.16A 1xp0A-5lhkA:
undetectable		 1xp0A-5lhkA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		5 LEU A1625
ILE A1621
VAL A1779
LEU A1061
PHE A1078
 None
 1.18A 1xp0A-5lkiA:
undetectable		 1xp0A-5lkiA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2

(Homo sapiens) 		PF00227
(Proteasome) 		5 LEU J 160
ALA J 156
ILE J   7
VAL J 182
LEU J  43
 None
 1.14A 1xp0A-5m32J:
undetectable		 1xp0A-5m32J:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m38 OMPA FAMILY PROTEIN

(Escherichia
coli) 		no annotation 5 LEU A  30
ALA A  29
ILE A  33
VAL A  67
ALA A  64
 None
 1.17A 1xp0A-5m38A:
undetectable		 1xp0A-5m38A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mj7 UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF01156
(IU_nuc_hydro) 		5 LEU A  26
ALA A  31
ILE A  33
VAL A 258
ALA A 257
 None
 1.07A 1xp0A-5mj7A:
undetectable		 1xp0A-5mj7A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		5 LEU A 370
ALA A 372
ILE A 377
VAL A 266
ALA A 229
 None
 1.12A 1xp0A-5n6mA:
undetectable		 1xp0A-5n6mA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 TYR A 319
ALA A 331
ILE A 335
VAL A 375
ALA A 273
 None
 1.16A 1xp0A-5nd4A:
undetectable		 1xp0A-5nd4A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 TYR A 319
ALA A 331
ILE A 335
VAL A 375
PHE A 296
 None
 1.10A 1xp0A-5nd4A:
undetectable		 1xp0A-5nd4A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng7 EPOXIDE HYDROLASE

(metagenome) 		no annotation 5 TYR A 148
ALA A 243
ILE A 244
VAL A 149
MET A 133
 None
 1.19A 1xp0A-5ng7A:
undetectable		 1xp0A-5ng7A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 5 LEU A 485
ALA A 489
ILE A 486
VAL A 502
PHE A 514
 None
 0.96A 1xp0A-5ot1A:
undetectable		 1xp0A-5ot1A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uft NITROGEN-FIXING
NIFU-LIKE,
N-TERMINAL

(Brucella
abortus) 		PF01592
(NifU_N) 		5 LEU A  84
ALA A 133
ILE A 136
VAL A  43
LEU A  23
 None
 1.11A 1xp0A-5uftA:
undetectable		 1xp0A-5uftA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xag TUBULIN TYROSINE
LIGASE

(Gallus gallus) 		no annotation 5 LEU F  21
ALA F  23
ALA F 344
LEU F 346
GLN F 348
 None
 1.05A 1xp0A-5xagF:
undetectable		 1xp0A-5xagF:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT F

(Flavobacterium
johnsoniae) 		no annotation 5 LEU F 164
ILE F 163
ALA F 155
LEU F 153
PHE F 160
 None
 1.12A 1xp0A-6btmF:
undetectable		 1xp0A-6btmF:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP2

(Escherichia
virus N4) 		no annotation 5 LEU B  87
ALA B 366
ILE B 365
VAL B  99
ALA B 402
 None
 1.16A 1xp0A-6c2jB:
undetectable		 1xp0A-6c2jB:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B

(Homo sapiens) 		no annotation 5 LEU A 472
ALA A 473
ILE A 475
VAL A 647
ALA A 648
 None
 1.15A 1xp0A-6ek6A:
undetectable		 1xp0A-6ek6A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gww PEROXIREDOXIN

(Sulfolobus
islandicus) 		no annotation 5 LEU A 154
ALA A 156
ILE A 157
VAL A 127
PHE A  63
 None
 1.11A 1xp0A-6gwwA:
undetectable		 1xp0A-6gwwA:
11.81