SIMILAR PATTERNS OF AMINO ACIDS FOR 1XOZ_A_CIAA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 263
ILE A 262
ILE A 240
VAL A 170
ILE A 227
None
0.93A 1xozA-1bxzA:
undetectable
1xozA-1bxzA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)


(Aspergillus
nidulans)
PF01761
(DHQ_synthase)
5 TYR A 323
ILE A 196
PHE A 188
LEU A 180
MET A 144
None
1.14A 1xozA-1dqsA:
undetectable
1xozA-1dqsA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II


(Synechocystis
sp. PCC 6803)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 ALA A  84
ILE A  17
ILE A 241
VAL A 355
LEU A  31
None
1.13A 1xozA-1e5mA:
undetectable
1xozA-1e5mA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ILE A 165
VAL A 167
PHE A 169
LEU A  38
ILE A  50
None
1.13A 1xozA-1fnoA:
undetectable
1xozA-1fnoA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqb NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A1191
ILE A1194
ILE A1164
PHE A1156
ILE A1265
None
1.03A 1xozA-1jqbA:
undetectable
1xozA-1jqbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcl CYCLODEXTRIN
GLYCOSYLTRANSFERASE


(Bacillus
circulans)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C)
5 ALA A 644
GLN A 586
VAL A 589
PHE A 591
LEU A 606
MPD  A1701 ( 4.0A)
None
None
None
None
1.05A 1xozA-1kclA:
undetectable
1xozA-1kclA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
5 ALA A 448
ILE A 451
ILE A 439
VAL A 437
ILE A 402
None
1.11A 1xozA-1moxA:
undetectable
1xozA-1moxA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger)
PF00295
(Glyco_hydro_28)
5 ALA A 157
ILE A 158
PHE A 220
LEU A 231
ILE A 212
None
1.08A 1xozA-1nhcA:
undetectable
1xozA-1nhcA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE


(Leishmania
major)
PF00581
(Rhodanese)
PF09122
(DUF1930)
5 TYR A 101
ALA A  55
ILE A  56
ILE A  30
LEU A  64
None
1.03A 1xozA-1okgA:
undetectable
1xozA-1okgA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus)
PF00491
(Arginase)
5 ILE A 208
VAL A 123
PHE A 231
LEU A 299
ILE A 264
None
0.99A 1xozA-1p8rA:
undetectable
1xozA-1p8rA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum)
PF00733
(Asn_synthase)
PF09147
(DUF1933)
5 ALA A 321
ILE A 306
ILE A 315
LEU A 486
ILE A 488
None
1.12A 1xozA-1q15A:
undetectable
1xozA-1q15A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmo MANNOSE BINDING
LECTIN, FRIL


(Lablab
purpureus)
PF00139
(Lectin_legB)
5 ALA E 180
ILE A  72
VAL E 137
LEU A 108
ILE A  92
None
1.13A 1xozA-1qmoE:
undetectable
1xozA-1qmoE:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qy9 HYPOTHETICAL PROTEIN
YDDE


(Escherichia
coli)
PF02567
(PhzC-PhzF)
5 ALA A  48
ILE A  60
VAL A  82
LEU A  87
ILE A 107
None
1.14A 1xozA-1qy9A:
undetectable
1xozA-1qy9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)


(Rhinovirus A)
PF00073
(Rhv)
5 ILE 3  44
VAL 3  40
PHE 1 116
LEU 1 115
ILE 2 185
None
1.14A 1xozA-1r1a3:
undetectable
1xozA-1r1a3:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE


(Homo sapiens)
PF00579
(tRNA-synt_1b)
5 ALA A 285
ILE A 254
VAL A 258
ILE A 278
PHE A 267
None
0.99A 1xozA-1r6uA:
undetectable
1xozA-1r6uA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urd MALTOSE-BINDING
PROTEIN


(Alicyclobacillus
acidocaldarius)
PF01547
(SBP_bac_1)
5 ALA A 377
ILE A 376
GLN A 373
ILE A 237
MET A 172
None
1.03A 1xozA-1urdA:
undetectable
1xozA-1urdA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrm HYPOTHETICAL PROTEIN
TM1553


(Thermotoga
maritima)
PF02424
(ApbE)
5 ALA A 205
ILE A 204
ILE A 225
VAL A 216
LEU A  53
None
MPD  A   1 ( 4.2A)
None
None
None
0.97A 1xozA-1vrmA:
undetectable
1xozA-1vrmA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Methanocaldococcus
jannaschii)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 ALA A 150
ILE A 151
GLN A 141
ILE A 138
MET A 119
None
0.86A 1xozA-1ys4A:
undetectable
1xozA-1ys4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A


(Homo sapiens)
PF00233
(PDEase_I)
6 TYR A 211
VAL A 380
PHE A 384
ILE A 409
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.82A 1xozA-1zklA:
38.4
1xozA-1zklA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A


(Homo sapiens)
PF00233
(PDEase_I)
6 TYR A 211
VAL A 380
PHE A 384
LEU A 401
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.87A 1xozA-1zklA:
38.4
1xozA-1zklA:
29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN


(Thermotoga
maritima)
PF13416
(SBP_bac_8)
5 ILE A 288
ILE A   9
VAL A  34
ILE A 279
PHE A 287
None
0.99A 1xozA-2fncA:
undetectable
1xozA-2fncA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2


(Mus musculus)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
5 ALA A 250
ILE A 254
VAL A  12
PHE A  44
MET A  41
None
1.12A 1xozA-2ho4A:
undetectable
1xozA-2ho4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3b HUMAN CANCER-RELATED
NTPASE


(Homo sapiens)
PF03266
(NTPase_1)
5 ILE A 138
VAL A   4
PHE A 166
LEU A 176
ILE A  18
None
1.05A 1xozA-2i3bA:
undetectable
1xozA-2i3bA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy9 SUBA

(Escherichia
coli)
PF00082
(Peptidase_S8)
5 ALA A 251
ILE A 249
ILE A 277
VAL A 281
ILE A 146
None
1.10A 1xozA-2iy9A:
undetectable
1xozA-2iy9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1


(Homo sapiens)
PF00171
(Aldedh)
5 ALA A 130
ILE A 126
ILE A 183
LEU A 267
ILE A 163
None
1.08A 1xozA-2j6lA:
undetectable
1xozA-2j6lA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgh DIAMINOPIMELATE
DECARBOXYLASE


(Helicobacter
pylori)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
5 ALA A 164
ILE A 134
VAL A 182
PHE A 220
LEU A 252
None
1.01A 1xozA-2qghA:
undetectable
1xozA-2qghA:
27.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1


(Leishmania
major)
PF00233
(PDEase_I)
5 TYR A 680
VAL A 853
PHE A 857
GLN A 887
PHE A 890
IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
0.49A 1xozA-2r8qA:
40.5
1xozA-2r8qA:
30.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110)
5 ALA A  82
ILE A 403
VAL A 134
PHE A 136
LEU A 145
None
1.13A 1xozA-2xvgA:
undetectable
1xozA-2xvgA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE


(Achromobacter
obae)
PF00202
(Aminotran_3)
5 ALA A 280
ILE A 284
VAL A 236
PHE A 203
ILE A 233
None
1.00A 1xozA-2zukA:
undetectable
1xozA-2zukA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai2 NADPH-SORBOSE
REDUCTASE


(Gluconobacter
frateurii)
PF13561
(adh_short_C2)
5 ALA A  10
ILE A  12
ILE A  88
VAL A 238
ILE A 185
None
1.06A 1xozA-3ai2A:
undetectable
1xozA-3ai2A:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE


(Homo sapiens)
PF00233
(PDEase_I)
11 TYR A 612
ALA A 767
ILE A 768
GLN A 775
ILE A 778
VAL A 782
PHE A 786
ILE A 813
MET A 816
GLN A 817
PHE A 820
VDN  A   1 (-4.8A)
VDN  A   1 ( 3.8A)
VDN  A   1 (-4.5A)
VDN  A   1 ( 4.4A)
None
VDN  A   1 ( 4.7A)
None
VDN  A   1 ( 4.2A)
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
0.53A 1xozA-3b2rA:
45.7
1xozA-3b2rA:
94.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE


(Homo sapiens)
PF00233
(PDEase_I)
11 TYR A 612
ALA A 767
ILE A 768
GLN A 775
ILE A 778
VAL A 782
PHE A 786
ILE A 813
MET A 816
GLN A 817
PHE A 820
None
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.6A)
None
WAN  A 901 ( 4.9A)
WAN  A 901 (-4.8A)
WAN  A 901 ( 4.3A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
0.68A 1xozA-3bjcA:
48.2
1xozA-3bjcA:
46.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9y PROFILIN

(Schizosaccharomyces
pombe)
PF00235
(Profilin)
5 ALA A 110
ILE A  88
PHE A  36
LEU A  38
ILE A  21
None
1.04A 1xozA-3d9yA:
undetectable
1xozA-3d9yA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddj CBS
DOMAIN-CONTAINING
PROTEIN


(Sulfolobus
solfataricus)
PF00571
(CBS)
5 ALA A  96
ILE A  99
ILE A   3
LEU A  45
ILE A  42
None
None
None
PEG  A 279 (-4.9A)
None
1.14A 1xozA-3ddjA:
undetectable
1xozA-3ddjA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80


(Kluyveromyces
lactis)
PF01408
(GFO_IDH_MocA)
5 ILE A 388
VAL A  91
PHE A  22
ILE A  87
PHE A  47
None
1.02A 1xozA-3e1kA:
undetectable
1xozA-3e1kA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebj POLYMERASE ACIDIC
PROTEIN


(Influenza A
virus)
PF00603
(Flu_PA)
5 ALA A  17
ILE A  13
ILE A  38
LEU A 109
PHE A  46
None
1.08A 1xozA-3ebjA:
undetectable
1xozA-3ebjA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2


(Burkholderia
pseudomallei)
PF00464
(SHMT)
5 ALA A 210
ILE A 209
VAL A 228
LEU A 202
ILE A 176
None
0.96A 1xozA-3ecdA:
undetectable
1xozA-3ecdA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR


(Shigella
flexneri)
PF04198
(Sugar-bind)
5 ALA A 232
ILE A 231
ILE A 162
LEU A 100
ILE A  93
None
1.11A 1xozA-3efbA:
undetectable
1xozA-3efbA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehc SNOAL-LIKE
POLYKETIDE CYCLASE


(Agrobacterium
fabrum)
PF07366
(SnoaL)
5 ALA A 121
ILE A 122
GLN A 125
LEU A  57
PHE A  85
None
0.95A 1xozA-3ehcA:
undetectable
1xozA-3ehcA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME


(Bacillus
subtilis)
PF00067
(p450)
5 ALA B 135
ILE B 131
ILE B 243
VAL B 247
LEU B 370
None
1.00A 1xozA-3ejbB:
undetectable
1xozA-3ejbB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii;
Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 263
ILE A 262
ILE A 240
VAL A 170
ILE A 227
None
0.88A 1xozA-3fplA:
undetectable
1xozA-3fplA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsr NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii;
Thermoanaerobacter
brockii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 191
ILE A 194
ILE A 164
PHE A 156
ILE A 265
None
1.01A 1xozA-3fsrA:
undetectable
1xozA-3fsrA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)


(Clostridium
acetobutylicum)
PF13377
(Peripla_BP_3)
5 ILE A 307
ILE A 149
VAL A 161
PHE A 326
ILE A 299
None
0.98A 1xozA-3g85A:
undetectable
1xozA-3g85A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gy9 GCN5-RELATED
N-ACETYLTRANSFERASE


(Exiguobacterium
sibiricum)
PF13673
(Acetyltransf_10)
5 ALA A  53
ILE A   5
LEU A 125
ILE A  78
MET A 101
None
1.02A 1xozA-3gy9A:
undetectable
1xozA-3gy9A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C)
5 TYR A1332
ILE A1211
VAL A1215
LEU A1291
ILE A1200
None
1.13A 1xozA-3hmjA:
undetectable
1xozA-3hmjA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana)
PF13847
(Methyltransf_31)
5 ALA A 312
ILE A 320
ILE A 224
LEU A 255
ILE A 249
None
1.05A 1xozA-3htxA:
undetectable
1xozA-3htxA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA


(Moorella
thermoacetica)
PF03063
(Prismane)
5 ALA A 397
ILE A 394
ILE A 291
PHE A 256
GLN A 293
None
0.94A 1xozA-3i04A:
undetectable
1xozA-3i04A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE


(Bacillus
anthracis)
PF13561
(adh_short_C2)
5 TYR A 262
ILE A  56
VAL A  60
PHE A  64
ILE A  73
None
NAE  A 311 (-3.8A)
None
None
None
1.11A 1xozA-3i3oA:
undetectable
1xozA-3i3oA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE


(Homo sapiens)
PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2)
5 TYR A 655
ILE A 822
ILE A 855
GLN A 859
PHE A 862
None
0.86A 1xozA-3ibjA:
38.3
1xozA-3ibjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jaf GLYCINE RECEPTOR
SUBUNIT ALPHAZ1


(Danio rerio)
PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb)
5 TYR A 357
ALA A 298
ILE A 299
ILE A 301
LEU A 248
None
1.07A 1xozA-3jafA:
undetectable
1xozA-3jafA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm4 CATECHOL
2,3-DIOXYGENASE


(Rhodococcus
jostii)
PF00903
(Glyoxalase)
6 TYR A 222
ALA A 231
ILE A 148
VAL A 150
LEU A  57
PHE A  27
None
1.35A 1xozA-3lm4A:
undetectable
1xozA-3lm4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2


(Drosophila
melanogaster)
PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N)
5 ALA X  41
ILE X  40
ILE X 337
VAL X 366
ILE X 491
None
1.10A 1xozA-3lxuX:
undetectable
1xozA-3lxuX:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbw ANHYDRO-N-ACETYLMURA
MIC ACID KINASE


(Pseudomonas
aeruginosa)
PF03702
(AnmK)
5 ALA A  59
ILE A  56
ILE A 110
VAL A 108
PHE A 106
None
0.87A 1xozA-3qbwA:
undetectable
1xozA-3qbwA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj9 ALCOHOL
DEHYDROGENASE


(Scaptodrosophila
lebanonensis)
PF00106
(adh_short)
5 ALA A 134
ILE A 133
ILE A  89
VAL A   8
ILE A  78
None
1.09A 1xozA-3rj9A:
undetectable
1xozA-3rj9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE


(Coxiella
burnetii)
PF00551
(Formyl_trans_N)
5 ILE A 111
ILE A 180
VAL A 184
PHE A 188
LEU A  86
None
0.89A 1xozA-3tqrA:
undetectable
1xozA-3tqrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
agalactiae)
PF00092
(VWA)
5 TYR A 529
ALA A 363
ILE A 366
ILE A 379
ILE A 259
None
1.04A 1xozA-3tw0A:
undetectable
1xozA-3tw0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE


(Trypanosoma
cruzi)
PF00233
(PDEase_I)
5 TYR A 367
ALA A 524
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.68A 1xozA-3v94A:
37.1
1xozA-3v94A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqi ATG5

(Kluyveromyces
marxianus)
PF04106
(APG5)
5 TYR A 267
ILE A 262
VAL A  88
ILE A  13
MET A  39
None
1.13A 1xozA-3vqiA:
undetectable
1xozA-3vqiA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL


(Trypanosoma
brucei)
PF01786
(AOX)
5 ALA A 226
ILE A 227
ILE A 110
VAL A 115
LEU A 172
None
0.84A 1xozA-3vvaA:
undetectable
1xozA-3vvaA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zok 3-DEHYDROQUINATE
SYNTHASE


(Actinidia
chinensis)
PF01761
(DHQ_synthase)
5 ALA A 283
VAL A 200
PHE A 211
LEU A 353
ILE A 205
None
1.06A 1xozA-3zokA:
undetectable
1xozA-3zokA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxy SUBTILISIN-LIKE
PROTEIN


(Prochloron
didemni)
PF00082
(Peptidase_S8)
5 ALA A 197
ILE A 195
ILE A 223
VAL A 227
ILE A 115
None
1.11A 1xozA-3zxyA:
undetectable
1xozA-3zxyA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP


(Corynebacterium
glutamicum)
PF02028
(BCCT)
5 ALA A  66
ILE A  69
ILE A 243
VAL A 247
LEU A 506
None
0.91A 1xozA-4ainA:
undetectable
1xozA-4ainA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 ALA A 269
ILE A 160
ILE A 284
LEU A 238
ILE A 144
None
0.99A 1xozA-4bziA:
undetectable
1xozA-4bziA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA


(Bacillus
thuringiensis)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
5 ILE A 664
ILE A 678
VAL A 676
PHE A 674
LEU A 631
None
1.02A 1xozA-4d8mA:
2.5
1xozA-4d8mA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djt GTP-BINDING NUCLEAR
PROTEIN GSP1


(Encephalitozoon
cuniculi)
PF00071
(Ras)
5 ALA A 152
ILE A 150
VAL A  18
LEU A  99
ILE A 131
GDP  A 301 (-3.7A)
None
GDP  A 301 (-3.9A)
None
None
1.04A 1xozA-4djtA:
undetectable
1xozA-4djtA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esj TYPE-2 RESTRICTION
ENZYME DPNI


(Streptococcus
pneumoniae)
PF06044
(DpnI)
5 ILE A 236
GLN A 233
ILE A 192
PHE A 117
PHE A 177
None
1.09A 1xozA-4esjA:
undetectable
1xozA-4esjA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN


(Chaetomium
thermophilum)
PF00012
(HSP70)
5 ALA A 153
ILE A 155
ILE A  16
VAL A 139
ILE A  47
None
1.11A 1xozA-4gniA:
undetectable
1xozA-4gniA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6w N-TERMINAL
CYANOBACTIN PROTEASE


(Planktothrix
agardhii)
PF00082
(Peptidase_S8)
5 ALA A 200
ILE A 198
ILE A 226
VAL A 230
ILE A 118
None
1.14A 1xozA-4h6wA:
undetectable
1xozA-4h6wA:
25.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE


(Homo sapiens)
PF00233
(PDEase_I)
5 TYR A 655
ILE A 822
PHE A 830
ILE A 855
GLN A 859
None
0.73A 1xozA-4htzA:
43.9
1xozA-4htzA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE


(Homo sapiens)
PF00233
(PDEase_I)
5 TYR A 655
PHE A 830
ILE A 855
GLN A 859
PHE A 862
None
0.40A 1xozA-4htzA:
43.9
1xozA-4htzA:
34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN


(Homo sapiens)
PF00012
(HSP70)
5 ILE A 334
ILE A 209
VAL A 207
PHE A 205
LEU A 200
None
1.11A 1xozA-4hwiA:
undetectable
1xozA-4hwiA:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1


(Trypanosoma
brucei)
PF00233
(PDEase_I)
5 TYR A 668
VAL A 840
PHE A 844
GLN A 874
PHE A 877
None
0.61A 1xozA-4i15A:
39.5
1xozA-4i15A:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A 307
ILE A 311
VAL A 182
LEU A 208
ILE A 189
None
0.93A 1xozA-4i6fA:
undetectable
1xozA-4i6fA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE


(Paenibacillus
macerans)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
5 ALA A 645
GLN A 587
VAL A 590
PHE A 592
LEU A 607
None
1.04A 1xozA-4jclA:
undetectable
1xozA-4jclA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8


(Homo sapiens)
PF00782
(DSPc)
5 ALA A 248
ILE A 250
PHE A 289
LEU A 221
ILE A 258
SO4  A 501 (-3.8A)
SO4  A 501 (-4.6A)
None
None
None
1.06A 1xozA-4jmkA:
undetectable
1xozA-4jmkA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5o POLYMERASE PA

(Influenza A
virus)
PF00603
(Flu_PA)
5 ALA A  17
ILE A  13
ILE A  38
LEU A 109
PHE A  46
None
None
X48  A 306 ( 4.9A)
None
None
1.00A 1xozA-4m5oA:
undetectable
1xozA-4m5oA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfz POLYMERASE PA

(Influenza A
virus)
PF00603
(Flu_PA)
5 ALA A  17
ILE A  13
ILE A  38
LEU A 109
PHE A  46
None
0.97A 1xozA-4nfzA:
undetectable
1xozA-4nfzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onr DECORIN-BINDING
PROTEIN DBPA


(Borreliella
burgdorferi)
PF02352
(Decorin_bind)
5 ILE A  96
ILE A 156
VAL A 138
LEU A 126
PHE A  92
None
1.10A 1xozA-4onrA:
undetectable
1xozA-4onrA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb0 AB53 HEAVY CHAIN
AB53 LIGHT CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 ILE H  89
PHE L  98
LEU L  36
ILE L  85
GLN L  38
None
1.08A 1xozA-4pb0H:
undetectable
1xozA-4pb0H:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297)
no annotation 5 ALA A 430
ILE A 460
ILE A 415
VAL A 425
ILE A 481
None
1.14A 1xozA-4ru5A:
undetectable
1xozA-4ru5A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE


(Homo sapiens)
PF00365
(PFK)
5 ALA A 190
ILE A 194
GLN A 309
ILE A 174
LEU A 239
None
0.96A 1xozA-4u1rA:
undetectable
1xozA-4u1rA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqm SOMATOLIBERIN,BOTULI
NUM NEUROTOXIN TYPE
D


(Clostridium
botulinum;
Homo sapiens)
PF07952
(Toxin_trans)
5 ALA B 799
ILE B 800
ILE B 640
PHE B 643
PHE B 671
None
0.89A 1xozA-5bqmB:
undetectable
1xozA-5bqmB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis)
PF00501
(AMP-binding)
5 GLN A 185
ILE A 199
PHE A  95
LEU A  91
ILE A  82
None
0.98A 1xozA-5d6nA:
undetectable
1xozA-5d6nA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtu PRP28

(Chaetomium
thermophilum)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 TYR A 488
ALA A 329
ILE A 307
ILE A 302
ILE A 271
None
1.14A 1xozA-5dtuA:
undetectable
1xozA-5dtuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN
ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
LIGHT CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 ALA H  92
ILE H  93
PHE L 107
ILE L  90
GLN L  39
None
1.08A 1xozA-5eorH:
undetectable
1xozA-5eorH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32


(Mycobacterium
marinum)
PF00501
(AMP-binding)
5 GLN A 184
ILE A 198
PHE A  95
LEU A  91
ILE A  82
None
1.02A 1xozA-5ey9A:
undetectable
1xozA-5ey9A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA


(Saccharomyces
cerevisiae)
PF00118
(Cpn60_TCP1)
5 ILE q 318
VAL q 305
LEU q 344
ILE q 284
MET q 287
None
1.00A 1xozA-5gw5q:
undetectable
1xozA-5gw5q:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei)
no annotation 5 TYR A 668
VAL A 841
PHE A 845
GLN A 875
PHE A 878
LLN  A1003 ( 4.8A)
LLN  A1003 (-4.6A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
0.67A 1xozA-5h2rA:
40.5
1xozA-5h2rA:
32.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9h ENVELOPMENT
POLYPROTEIN


(Puumala
orthohantavirus)
PF01561
(Hanta_G2)
5 ILE A 943
VAL A 938
PHE A 936
ILE A 722
PHE A 804
None
1.14A 1xozA-5j9hA:
undetectable
1xozA-5j9hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2,NADH
DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2


(Bos taurus)
PF00346
(Complex1_49kDa)
PF00361
(Proton_antipo_M)
PF06444
(NADH_dehy_S2_C)
5 ALA d  47
ILE d  48
ILE N 239
VAL N 242
MET N 215
None
1.08A 1xozA-5lc5d:
undetectable
1xozA-5lc5d:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m49 AMINOTRANSFERASE
CLASS-III


(Rhizobium
freirei)
PF00202
(Aminotran_3)
5 ALA A 280
ILE A 284
VAL A 236
PHE A 203
ILE A 233
None
0.96A 1xozA-5m49A:
undetectable
1xozA-5m49A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum)
PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127)
5 ILE A 211
ILE A 332
VAL A 272
LEU A 376
PHE A 336
None
1.12A 1xozA-5o0sA:
undetectable
1xozA-5o0sA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)


(Mycobacterium
tuberculosis)
PF00975
(Thioesterase)
5 ALA A1702
ILE A1703
ILE A1707
VAL A1711
LEU A1491
None
1.11A 1xozA-5v41A:
undetectable
1xozA-5v41A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE


(Aedes aegypti)
no annotation 5 ALA A 267
ILE A 250
VAL A 219
ILE A 237
MET A 243
None
1.02A 1xozA-5vehA:
undetectable
1xozA-5vehA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfp EXOCYST COMPLEX
COMPONENT EXO84
EXOCYST COMPLEX
COMPONENT SEC5


(Saccharomyces
cerevisiae)
no annotation 5 ALA B 968
VAL H 691
LEU H 633
ILE H 668
PHE H 675
None
1.13A 1xozA-5yfpB:
undetectable
1xozA-5yfpB:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysq TM0415

(Thermotoga
maritima)
no annotation 5 ALA A  31
ILE A  32
VAL A  65
PHE A  67
PHE A  57
None
0.92A 1xozA-5ysqA:
undetectable
1xozA-5ysqA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2


(Candidatus
Methanoperedens
nitroreducens)
no annotation 5 ALA A  35
ILE A  38
ILE A  52
VAL A  50
ILE A  73
None
1.07A 1xozA-6bxnA:
undetectable
1xozA-6bxnA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED


(Escherichia
coli;
Xenopus laevis)
no annotation 5 ALA A 468
ILE A 469
GLN A 165
LEU A  46
ILE A  50
None
1.04A 1xozA-6d35A:
undetectable
1xozA-6d35A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejj WLAC PROTEIN

(Campylobacter
jejuni)
no annotation 5 ALA A 221
ILE A 220
ILE A 189
LEU A 313
MET A 200
UDP  A 401 ( 4.0A)
None
None
None
None
0.99A 1xozA-6ejjA:
undetectable
1xozA-6ejjA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC


(Spinacia
oleracea)
no annotation 5 ALA C 113
ILE C 109
ILE C  98
PHE C 250
ILE C 259
None
0.99A 1xozA-6fkhC:
undetectable
1xozA-6fkhC:
10.67