SIMILAR PATTERNS OF AMINO ACIDS FOR 1XOS_A_VIAA1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1

(Homo sapiens) 		PF01704
(UDPGP) 		5 LEU A 106
SER A 173
MET A 171
GLN A 233
PHE A 194
 None
 1.48A 1xosA-1jv1A:
undetectable		 1xosA-1jv1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 ASP A 266
LEU A 267
SER A 190
MET A 242
PHE A 208
 None
 1.48A 1xosA-1lq2A:
undetectable		 1xosA-1lq2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sa8 FATTY ACID-BINDING
PROTEIN, INTESTINAL

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		5 LEU A  88
PHE A  37
GLN A  17
PHE A   2
ILE A  83
 None
 1.38A 1xosA-1sa8A:
undetectable		 1xosA-1sa8A:
13.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 736
HIS A 737
ASP A 937
PHE A 959
GLN A 988
PHE A 991
ILE A 995
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
None
 0.52A 1xosA-1sojA:
41.8		 1xosA-1sojA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 736
HIS A 737
ASP A 937
PHE A 959
SER A 974
GLN A 988
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 (-3.3A)
 1.00A 1xosA-1sojA:
41.8		 1xosA-1sojA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 736
HIS A 741
GLN A 988
PHE A 991
ILE A 995
 IBM  A2111 (-4.5A)
MG  A2123 (-3.0A)
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
None
 1.48A 1xosA-1sojA:
41.8		 1xosA-1sojA:
30.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2b 23-KDA POLYPEPTIDE
OF PHOTOSYSTEM II
OXYGEN-EVOLVING
COMPLEX

(Nicotiana
tabacum) 		PF01789
(PsbP) 		5 TYR A  86
LEU A 156
GLN A  83
PHE A  74
ILE A  71
 None
 1.29A 1xosA-1v2bA:
undetectable		 1xosA-1v2bA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		5 MET A 235
LEU A 227
MET A 344
SER A 246
ILE A 133
 None
 1.17A 1xosA-1zbuA:
undetectable		 1xosA-1zbuA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 211
HIS A 212
ASP A 362
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.47A 1xosA-1zklA:
45.2		 1xosA-1zklA:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 TYR A 192
LEU A 108
PHE A 147
SER A 172
ILE A  47
 None
 1.38A 1xosA-1zliA:
undetectable		 1xosA-1zliA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 MET B 372
ASP B 377
PHE B 490
SER B 592
ILE B 454
 None
 1.32A 1xosA-2c6wB:
undetectable		 1xosA-2c6wB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9j REGULATOR OF
G-PROTEIN SIGNALLING
7

(Homo sapiens) 		PF00615
(RGS) 		5 LEU A  74
SER A 119
MET A 115
GLN A 108
PHE A  47
 None
 1.47A 1xosA-2d9jA:
undetectable		 1xosA-2d9jA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 HIS X 149
ASP X 349
LEU X 347
MET X 297
GLN X 339
 None
None
None
UNX  X 804 (-3.8A)
None
 1.34A 1xosA-2iv2X:
undetectable		 1xosA-2iv2X:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lez SECRETED EFFECTOR
PROTEIN PIPB2

(Salmonella
enterica) 		no annotation 5 TYR A  36
LEU A  82
PHE A  40
PHE A  92
ILE A  80
 None
 1.28A 1xosA-2lezA:
undetectable		 1xosA-2lezA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjs UNCHARACTERIZED
PROTEIN ATU1953

(Agrobacterium
fabrum) 		PF00903
(Glyoxalase) 		5 LEU A 102
SER A  42
MET A  28
PHE A  21
ILE A 110
 None
 1.30A 1xosA-2pjsA:
undetectable		 1xosA-2pjsA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 LEU A 346
SER A 367
GLN A 445
PHE A 401
ILE A 356
 None
 1.50A 1xosA-2pvsA:
undetectable		 1xosA-2pvsA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 371
HIS A 372
MET A 485
ASP A 530
LEU A 531
MET A 549
PHE A 552
MET A 569
GLN A 581
PHE A 584
ILE A 588
 NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
ZN  A   1 (-2.5A)
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-4.8A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
None
 0.42A 1xosA-2qykA:
52.1		 1xosA-2qykA:
87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 371
HIS A 376
MET A 485
LEU A 531
GLN A 581
PHE A 584
ILE A 588
 NPV  A   3 (-4.4A)
ZN  A   1 (-3.3A)
None
None
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
None
 1.49A 1xosA-2qykA:
52.1		 1xosA-2qykA:
87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 371
MET A 485
ASP A 530
LEU A 531
MET A 549
PHE A 552
SER A 567
PHE A 584
 NPV  A   3 (-4.4A)
None
ZN  A   1 (-2.5A)
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-4.8A)
None
NPV  A   3 (-3.3A)
 1.15A 1xosA-2qykA:
52.1		 1xosA-2qykA:
87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qym PHOSPHODIESTERASE 4C

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 281
HIS A 282
MET A 395
ASP A 440
LEU A 441
PHE A 494
ILE A 498
 None
None
None
ZN  A   1 (-2.5A)
None
None
None
 0.52A 1xosA-2qymA:
43.4		 1xosA-2qymA:
75.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		7 TYR A 680
HIS A 681
MET A 797
ASP A 835
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.76A 1xosA-2r8qA:
39.8		 1xosA-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		7 TYR A 680
HIS A 681
MET A 797
ASP A 835
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.52A 1xosA-2r8qA:
39.8		 1xosA-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 TYR G1733
LEU G1717
GLN G1775
PHE G1776
ILE G1709
 None
 1.21A 1xosA-2uv8G:
undetectable		 1xosA-2uv8G:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wae PENICILLIN-BINDING
PROTEIN 2B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ASP A 288
LEU A 287
MET A  88
PHE A 187
ILE A 285
 None
 1.32A 1xosA-2waeA:
undetectable		 1xosA-2waeA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrd HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 MET A 150
LEU A  66
SER A 212
PHE A  99
ILE A 178
 None
 1.47A 1xosA-2wrdA:
undetectable		 1xosA-2wrdA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780

(Pyrococcus
horikoshii) 		PF00571
(CBS) 		5 TYR A 131
LEU A 277
MET A 247
PHE A 117
ILE A 112
 None
 1.49A 1xosA-2yzqA:
undetectable		 1xosA-2yzqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B

(Homo sapiens) 		PF01419
(Jacalin) 		5 LEU A 113
MET A 133
PHE A 145
SER A  88
ILE A  74
 None
 1.40A 1xosA-3aqgA:
undetectable		 1xosA-3aqgA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 775
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.4A)
 0.94A 1xosA-3b2rA:
31.1		 1xosA-3b2rA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 786
GLN A 817
PHE A 820
ILE A 824
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
None
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
None
 0.65A 1xosA-3b2rA:
31.1		 1xosA-3b2rA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 775
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.6A)
 0.84A 1xosA-3bjcA:
33.9		 1xosA-3bjcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 786
GLN A 817
PHE A 820
ILE A 824
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
None
 0.57A 1xosA-3bjcA:
33.9		 1xosA-3bjcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 612
HIS A 617
GLN A 817
PHE A 820
ILE A 824
 None
ZN  A 876 (-3.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
None
 1.33A 1xosA-3bjcA:
33.9		 1xosA-3bjcA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 ASP A 395
LEU A 350
MET A 525
PHE A 526
PHE A 561
 EDO  A 803 (-2.6A)
None
None
None
None
 1.24A 1xosA-3cihA:
undetectable		 1xosA-3cihA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmc NTF2-LIKE PROTEIN

(Trichormus
variabilis) 		PF12680
(SnoaL_2) 		5 TYR A 122
LEU A  24
PHE A 112
PHE A  93
ILE A  76
 None
 1.39A 1xosA-3dmcA:
undetectable		 1xosA-3dmcA:
15.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 555
HIS A 556
MET A 670
ASP A 726
GLN A 778
PHE A 781
 None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.44A 1xosA-3ecnA:
44.8		 1xosA-3ecnA:
34.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3er7 UNCHARACTERIZED
NTF2-LIKE PROTEIN

(Exiguobacterium
sibiricum) 		PF12680
(SnoaL_2) 		5 HIS A  66
ASP A 102
LEU A 115
PHE A  31
ILE A 112
 PEG  A 132 (-3.9A)
PEG  A 132 (-2.7A)
None
None
None
 1.30A 1xosA-3er7A:
undetectable		 1xosA-3er7A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fez UNCHARACTERIZED
FERREDOXIN FOLD
PROTEIN RELATED TO
ANTIBIOTIC
BIOSYNTHESIS
MONOOXYGENASES

(Listeria
monocytogenes) 		no annotation 5 LEU A  36
PHE A 119
SER A  58
PHE A  70
ILE A   6
 None
 1.27A 1xosA-3fezA:
undetectable		 1xosA-3fezA:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 330
MET A 439
LEU A 485
GLN A 535
PHE A 538
 ZN  A 801 (-3.4A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 1.13A 1xosA-3g4gA:
51.0		 1xosA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		6 MET A 439
LEU A 485
MET A 503
PHE A 506
GLN A 535
PHE A 538
 D71  A 901 ( 4.0A)
None
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.85A 1xosA-3g4gA:
51.0		 1xosA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		9 TYR A 325
HIS A 326
ASP A 484
LEU A 485
MET A 503
PHE A 506
GLN A 535
PHE A 538
ILE A 542
 None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
None
 0.52A 1xosA-3g4gA:
51.0		 1xosA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 325
HIS A 326
ASP A 484
MET A 503
PHE A 506
SER A 521
 None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
None
 1.02A 1xosA-3g4gA:
51.0		 1xosA-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 325
HIS A 326
MET A 503
PHE A 506
MET A 523
GLN A 535
 None
D71  A 901 (-4.5A)
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.1A)
 0.77A 1xosA-3g4gA:
51.0		 1xosA-3g4gA:
66.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcd RTX TOXIN RTXA

(Vibrio cholerae) 		PF11713
(Peptidase_C80) 		5 TYR A 106
MET A 159
LEU A 115
PHE A 151
ILE A 135
 None
 1.47A 1xosA-3gcdA:
undetectable		 1xosA-3gcdA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		6 TYR A 655
HIS A 656
ASP A 808
GLN A 859
PHE A 862
ILE A 866
 None
None
ZN  A   1 (-2.7A)
None
None
None
 0.54A 1xosA-3ibjA:
32.7		 1xosA-3ibjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		6 TYR A 655
HIS A 656
ASP A 808
LEU A 809
PHE A 862
ILE A 866
 None
None
ZN  A   1 (-2.7A)
None
None
None
 0.74A 1xosA-3ibjA:
32.7		 1xosA-3ibjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 TYR A 655
HIS A 660
GLN A 859
PHE A 862
ILE A 866
 None
ZN  A   1 (-3.4A)
None
None
None
 1.49A 1xosA-3ibjA:
32.7		 1xosA-3ibjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibx PUTATIVE THIAMINASE
II

(Helicobacter
pylori) 		PF03070
(TENA_THI-4) 		5 TYR A 139
ASP A  44
LEU A  48
PHE A 170
ILE A  78
 None
 1.43A 1xosA-3ibxA:
undetectable		 1xosA-3ibxA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		5 HIS A 236
LEU A 210
GLN A 185
PHE A 279
ILE A 192
 None
 1.48A 1xosA-3ihpA:
undetectable		 1xosA-3ihpA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 ASP A 482
LEU A 486
GLN A 503
PHE A 506
ILE A 462
 None
 1.36A 1xosA-3khkA:
undetectable		 1xosA-3khkA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1

(Homo sapiens) 		PF01369
(Sec7) 		5 HIS A 770
MET A 801
LEU A 781
PHE A 788
ILE A 832
 CA  A   2 (-4.0A)
None
None
None
None
 1.16A 1xosA-3ltlA:
undetectable		 1xosA-3ltlA:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 252
MET A 365
ASP A 402
GLN A 453
PHE A 456
 None
None
ZN  A 507 (-2.9A)
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
 0.51A 1xosA-3n3zA:
41.3		 1xosA-3n3zA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 233
HIS A 234
MET A 347
ASP A 392
LEU A 393
MET A 411
PHE A 414
GLN A 443
PHE A 446
ILE A 450
 None
None
ZG2  A 506 (-3.9A)
ZN  A   1 (-2.6A)
None
None
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
None
 0.52A 1xosA-3o57A:
53.2		 1xosA-3o57A:
93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 233
HIS A 234
MET A 347
ASP A 392
LEU A 393
MET A 411
PHE A 414
MET A 431
GLN A 443
PHE A 446
 None
None
ZG2  A 506 (-3.9A)
ZN  A   1 (-2.6A)
None
None
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.4A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
 0.57A 1xosA-3o57A:
53.2		 1xosA-3o57A:
93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		9 TYR A 233
HIS A 234
MET A 347
ASP A 392
MET A 411
PHE A 414
SER A 429
GLN A 443
PHE A 446
 None
None
ZG2  A 506 (-3.9A)
ZN  A   1 (-2.6A)
None
ZG2  A 506 (-4.4A)
ARS  A   3 (-4.4A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
 0.91A 1xosA-3o57A:
53.2		 1xosA-3o57A:
93.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pam TRANSMEMBRANE
PROTEIN

(Bartonella
henselae) 		PF00496
(SBP_bac_5) 		5 LEU A 424
PHE A 325
MET A 494
PHE A 444
ILE A 471
 None
 1.49A 1xosA-3pamA:
undetectable		 1xosA-3pamA:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
MET A 337
PHE A 340
MET A 357
GLN A 369
PHE A 372
ILE A 376
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
ILE  A 376 (-0.6A)
 0.48A 1xosA-3sl5A:
51.3		 1xosA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
MET A 337
PHE A 340
SER A 355
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
SER  A 355 ( 0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 1.02A 1xosA-3sl5A:
51.3		 1xosA-3sl5A:
84.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tql ARGININE-BINDING
PROTEIN

(Coxiella
burnetii) 		PF00497
(SBP_bac_3) 		5 TYR A 124
MET A  78
LEU A 245
PHE A  45
ILE A  43
 None
 1.47A 1xosA-3tqlA:
undetectable		 1xosA-3tqlA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 524
ASP A 674
LEU A 675
MET A 713
GLN A 726
PHE A 729
 C1L  A   1 ( 4.8A)
ZN  A 772 (-2.4A)
C1L  A   1 (-4.3A)
C1L  A   1 (-3.7A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
 1.19A 1xosA-3ui7A:
38.3		 1xosA-3ui7A:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 524
HIS A 525
ASP A 674
LEU A 675
PHE A 696
GLN A 726
PHE A 729
 C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
ZN  A 772 (-2.4A)
C1L  A   1 (-4.3A)
C1L  A   1 ( 4.7A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
 0.70A 1xosA-3ui7A:
38.3		 1xosA-3ui7A:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		5 TYR A 539
SER A 441
GLN A 424
PHE A 432
ILE A 140
 None
 1.44A 1xosA-3up4A:
undetectable		 1xosA-3up4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		5 MET A 482
ASP A 521
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.97A 1xosA-3v94A:
40.0		 1xosA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		6 TYR A 367
HIS A 368
ASP A 521
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
ZN  A 702 (-1.9A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.74A 1xosA-3v94A:
40.0		 1xosA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
ALPHA SUBUNIT
2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
BETA SUBUNIT

(Comamonas
testosteroni) 		PF02900
(LigB) 		5 ASP A  58
LEU A  57
SER B  30
PHE B  86
ILE B 280
 None
None
None
2XP  B 402 (-4.3A)
None
 1.33A 1xosA-3vsjA:
undetectable		 1xosA-3vsjA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		5 MET A 356
LEU A 242
SER A 396
PHE A 128
ILE A 132
 None
 1.27A 1xosA-3zbyA:
undetectable		 1xosA-3zbyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bm1 MANGANESE PEROXIDASE
4

(Pleurotus
ostreatus) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 LEU A  29
SER A  76
MET A  73
PHE A 109
ILE A  98
 None
 1.40A 1xosA-4bm1A:
undetectable		 1xosA-4bm1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
subtilis) 		PF02350
(Epimerase_2) 		5 TYR A 237
ASP A 283
LEU A 301
PHE A 253
ILE A 326
 None
 1.50A 1xosA-4fkzA:
undetectable		 1xosA-4fkzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbm CURM
SULFOTRANSFERASE

(Moorea
producens) 		PF13469
(Sulfotransfer_3) 		5 MET A  48
LEU A 221
PHE A 240
GLN A 227
ILE A 275
 None
 1.31A 1xosA-4gbmA:
undetectable		 1xosA-4gbmA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 655
ASP A 808
LEU A 809
MET A 847
GLN A 859
PHE A 862
ILE A 866
 None
ZN  A1001 (-2.5A)
None
None
None
None
None
 0.90A 1xosA-4htzA:
38.8		 1xosA-4htzA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 655
HIS A 656
ASP A 808
LEU A 809
PHE A 830
GLN A 859
PHE A 862
ILE A 866
 None
None
ZN  A1001 (-2.5A)
None
None
None
None
None
 0.60A 1xosA-4htzA:
38.8		 1xosA-4htzA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 655
HIS A 660
GLN A 859
PHE A 862
ILE A 866
 None
ZN  A1001 (-3.4A)
None
None
None
 1.38A 1xosA-4htzA:
38.8		 1xosA-4htzA:
27.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		8 TYR A 668
HIS A 669
MET A 785
ASP A 822
PHE A 844
MET A 861
GLN A 874
PHE A 877
 None
None
None
ZN  A1001 (-2.5A)
None
None
None
None
 0.87A 1xosA-4i15A:
38.8		 1xosA-4i15A:
31.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kia LMO2213 PROTEIN

(Listeria
monocytogenes) 		no annotation 5 LEU A  36
PHE A 119
SER A  58
PHE A  70
ILE A   6
 None
 1.27A 1xosA-4kiaA:
undetectable		 1xosA-4kiaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 LEU A1305
PHE A1283
SER A1288
PHE A1342
ILE A1346
 None
 1.48A 1xosA-4ll8A:
undetectable		 1xosA-4ll8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 LEU A 410
PHE A 154
MET A 153
PHE A 448
ILE A 282
 None
None
NO3  A 502 ( 4.6A)
None
NO3  A 502 (-4.8A)
 1.29A 1xosA-4o6rA:
undetectable		 1xosA-4o6rA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rti OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF01789
(PsbP) 		5 TYR A  86
LEU A 156
GLN A  83
PHE A  74
ILE A  71
 None
 1.41A 1xosA-4rtiA:
undetectable		 1xosA-4rtiA:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		9 TYR A 405
HIS A 406
ASP A 564
LEU A 565
MET A 583
PHE A 586
GLN A 615
PHE A 618
ILE A 622
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
 0.56A 1xosA-4wziA:
52.2		 1xosA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 405
HIS A 406
ASP A 564
MET A 583
PHE A 586
SER A 601
GLN A 615
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
 1.10A 1xosA-4wziA:
52.2		 1xosA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 405
HIS A 406
MET A 583
PHE A 586
MET A 603
GLN A 615
 None
MG  A 804 ( 4.9A)
None
None
None
None
 0.84A 1xosA-4wziA:
52.2		 1xosA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 405
HIS A 410
LEU A 565
GLN A 615
PHE A 618
ILE A 622
 None
ZN  A 801 (-3.2A)
None
None
None
None
 1.45A 1xosA-4wziA:
52.2		 1xosA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 405
MET A 519
ASP A 564
LEU A 565
MET A 583
PHE A 586
GLN A 615
PHE A 618
 None
None
ZN  A 801 (-2.5A)
None
None
None
None
None
 0.80A 1xosA-4wziA:
52.2		 1xosA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 405
MET A 519
ASP A 564
MET A 583
PHE A 586
SER A 601
GLN A 615
 None
None
ZN  A 801 (-2.5A)
None
None
None
None
 1.22A 1xosA-4wziA:
52.2		 1xosA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 222
HIS A 223
MET A 336
ASP A 370
PHE A 392
GLN A 421
PHE A 424
ILE A 428
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
None
 0.66A 1xosA-5b25A:
43.9		 1xosA-5b25A:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 222
HIS A 223
MET A 336
ASP A 370
PHE A 392
SER A 407
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
GOL  A 607 (-3.9A)
GOL  A 607 (-4.1A)
 1.12A 1xosA-5b25A:
43.9		 1xosA-5b25A:
35.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5byp PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF16585
(Lipocalin_8) 		5 TYR A  40
PHE A 147
MET A 136
PHE A 126
ILE A  89
 None
 1.40A 1xosA-5bypA:
undetectable		 1xosA-5bypA:
13.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 8 TYR A 668
HIS A 669
MET A 785
ASP A 823
PHE A 845
MET A 862
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
ZN  A1001 (-2.6A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.72A 1xosA-5h2rA:
39.6		 1xosA-5h2rA:
32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mog PHYTOENE
DEHYDROGENASE,
CHLOROPLASTIC/CHROMO
PLASTIC

(Oryza sativa) 		PF01593
(Amino_oxidase) 		5 LEU A 298
PHE A 190
SER A 430
PHE A 274
ILE A 294
 None
 1.33A 1xosA-5mogA:
undetectable		 1xosA-5mogA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nva PUTATIVE
SODIUM:SOLUTE
SYMPORTER

(Proteus
mirabilis) 		no annotation 5 MET A 151
LEU A 158
PHE A  15
GLN A 341
PHE A 337
 None
 1.49A 1xosA-5nvaA:
undetectable		 1xosA-5nvaA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 11 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
MET A 583
PHE A 586
MET A 603
GLN A 615
PHE A 618
ILE A 622
 None
None
9VE  A 801 (-3.8A)
ZN  A 699 ( 2.6A)
9VE  A 801 (-4.7A)
9VE  A 801 ( 4.0A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.8A)
 0.61A 1xosA-5ohjA:
52.1		 1xosA-5ohjA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 7 TYR A 405
HIS A 406
MET A 519
ASP A 564
MET A 583
PHE A 586
SER A 601
 None
None
9VE  A 801 (-3.8A)
ZN  A 699 ( 2.6A)
9VE  A 801 ( 4.0A)
9VE  A 801 (-3.6A)
None
 1.21A 1xosA-5ohjA:
52.1		 1xosA-5ohjA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 7 TYR A 405
HIS A 410
MET A 519
LEU A 565
GLN A 615
PHE A 618
ILE A 622
 None
ZN  A 699 (-3.3A)
9VE  A 801 (-3.8A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.8A)
 1.46A 1xosA-5ohjA:
52.1		 1xosA-5ohjA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN

(Bos taurus;
Mus musculus) 		PF00654
(Voltage_CLC)
PF07686
(V-set) 		5 TYR L  94
LEU A 370
SER L  26
MET L   4
GLN L  89
 None
 1.47A 1xosA-5tr1L:
undetectable		 1xosA-5tr1L:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta) 		no annotation 6 HIS A  83
MET A 195
ASP A 236
LEU A 237
PHE A 258
PHE A 291
 None
None
ZN  A 401 (-2.4A)
None
None
None
 0.62A 1xosA-5vydA:
40.3		 1xosA-5vydA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 11 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
MET A 337
PHE A 340
MET A 357
GLN A 369
PHE A 372
ILE A 376
 AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
ZN  A 602 (-2.5A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 ( 3.7A)
AKJ  A 601 (-4.5A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
None
 0.52A 1xosA-5wh6A:
52.3		 1xosA-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 9 TYR A 159
HIS A 160
MET A 273
ASP A 318
MET A 337
PHE A 340
SER A 355
GLN A 369
PHE A 372
 AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
ZN  A 602 (-2.5A)
AKJ  A 601 ( 3.7A)
AKJ  A 601 (-4.5A)
None
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
 1.04A 1xosA-5wh6A:
52.3		 1xosA-5wh6A:
undetectable