SIMILAR PATTERNS OF AMINO ACIDS FOR 1XOQ_B_ROFB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR

(Bos taurus) 		PF00996
(GDI) 		5 LEU A 231
TYR A 404
THR A  15
ILE A  18
PHE A 410
 None
 1.41A 1xoqB-1d5tA:
undetectable		 1xoqB-1d5tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		5 LEU A  83
TRP A 239
ILE A  78
SER A 150
PHE A 152
 None
 1.33A 1xoqB-1ehkA:
undetectable		 1xoqB-1ehkA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiu TYPE II RESTRICTION
ENZYME NGOMI

(Neisseria
gonorrhoeae) 		PF09015
(NgoMIV_restric) 		5 HIS A  13
ASP A 276
LEU A 246
ILE A  47
SER A  40
 None
 1.44A 1xoqB-1fiuA:
undetectable		 1xoqB-1fiuA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		5 LEU A 127
PRO A 130
THR A 294
ILE A 296
PHE A 134
 None
 1.49A 1xoqB-1fw8A:
undetectable		 1xoqB-1fw8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 207
PRO A 209
TYR A 334
THR A 330
ILE A 327
 None
 1.29A 1xoqB-1g1aA:
undetectable		 1xoqB-1g1aA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1je6 MHC CLASS I
CHAIN-RELATED
PROTEIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 HIS A 156
ASP A  72
LEU A  73
THR A 143
PHE A 110
 None
 1.30A 1xoqB-1je6A:
undetectable		 1xoqB-1je6A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F

(Corynebacterium
ammoniagenes) 		PF00268
(Ribonuc_red_sm) 		5 ASP A  51
LEU A 188
PRO A 179
ILE A 194
PHE A  70
 None
 1.48A 1xoqB-1kgpA:
undetectable		 1xoqB-1kgpA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		5 TYR B 118
LEU B 111
ILE B  84
SER B  70
PHE B  71
 None
 1.41A 1xoqB-1mioB:
undetectable		 1xoqB-1mioB:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 737
ASP A 937
PRO A 941
SER A 990
PHE A 991
 IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 (-3.6A)
 1.25A 1xoqB-1sojA:
42.2		 1xoqB-1sojA:
31.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
THR A 952
ILE A 955
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.6A)
 0.52A 1xoqB-1sojA:
42.2		 1xoqB-1sojA:
31.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		5 LEU A 642
THR A 559
ILE A 562
SER A 589
PHE A 591
 None
 1.36A 1xoqB-1uf2A:
undetectable		 1xoqB-1uf2A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um1 KIAA1849 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 ASP A  27
LEU A  38
THR A  99
ILE A 103
SER A  56
 None
 1.48A 1xoqB-1um1A:
undetectable		 1xoqB-1um1A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 LEU A 256
PRO A 195
TRP A 209
THR A 208
ILE A 210
 None
 1.43A 1xoqB-1urtA:
undetectable		 1xoqB-1urtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1viw ALPHA-AMYLASE-INHIBI
TOR

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 ASP B  83
LEU B  82
ILE B 137
SER B 199
PHE B  66
 None
None
None
NAG  B 509 (-2.4A)
None
 1.46A 1xoqB-1viwB:
undetectable		 1xoqB-1viwB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE

(Sulfolobus
solfataricus) 		PF00701
(DHDPS) 		5 TYR A 246
LEU A  23
TYR A 255
THR A 249
SER A 200
 None
 1.42A 1xoqB-1w3iA:
undetectable		 1xoqB-1w3iA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		5 ASP A 490
LEU A 488
TYR A 520
THR A 535
ILE A 427
 None
 1.29A 1xoqB-1z45A:
undetectable		 1xoqB-1z45A:
18.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-3.4A)
 0.36A 1xoqB-1zklA:
45.5		 1xoqB-1zklA:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1znp HYPOTHETICAL PROTEIN
ATU3615

(Agrobacterium
fabrum) 		PF06172
(Cupin_5) 		5 TYR A  25
HIS A  19
THR A  28
ILE A  43
SER A  40
 None
 1.35A 1xoqB-1znpA:
undetectable		 1xoqB-1znpA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amx ADENOSINE DEAMINASE

(Plasmodium
yoelii) 		PF00962
(A_deaminase) 		5 HIS A 239
ASP A 324
LEU A  60
ILE A 183
SER A 147
 CO  A1000 (-3.4A)
None
None
None
None
 1.26A 1xoqB-2amxA:
undetectable		 1xoqB-2amxA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2evr COG0791: CELL
WALL-ASSOCIATED
HYDROLASES
(INVASION-ASSOCIATED
PROTEINS)

(Nostoc
punctiforme) 		PF00877
(NLPC_P60) 		5 ASP A 164
THR A 104
ILE A 101
SER A 136
PHE A 134
 None
 1.38A 1xoqB-2evrA:
undetectable		 1xoqB-2evrA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A

(Homo sapiens) 		PF00025
(Arf) 		5 LEU A 128
THR A  24
ILE A  67
MET A  21
SER A  90
 None
 1.25A 1xoqB-2h18A:
undetectable		 1xoqB-2h18A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hbw NLP/P60 PROTEIN

(Trichormus
variabilis) 		PF00877
(NLPC_P60) 		5 ASP A 164
THR A 104
ILE A 101
SER A 136
PHE A 134
 None
 1.36A 1xoqB-2hbwA:
undetectable		 1xoqB-2hbwA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jem ENDO-BETA-1,4-GLUCAN
ASE

(Bacillus
licheniformis) 		PF01670
(Glyco_hydro_12) 		5 LEU A 160
TYR A  89
ILE A 251
MET A  73
PHE A 240
 None
 1.11A 1xoqB-2jemA:
undetectable		 1xoqB-2jemA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		5 ASP A 156
LEU A  66
ILE A 159
MET A 181
PHE A 283
 None
 1.41A 1xoqB-2ozeA:
undetectable		 1xoqB-2ozeA:
23.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		12 TYR A 371
HIS A 372
ASP A 530
LEU A 531
PRO A 534
TYR A 541
TRP A 544
THR A 545
ILE A 548
MET A 569
SER A 580
PHE A 584
 NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
ZN  A   1 (-2.5A)
None
None
None
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.8A)
NPV  A   3 (-3.1A)
NPV  A   3 (-4.5A)
NPV  A   3 (-3.3A)
 0.49A 1xoqB-2qykA:
51.9		 1xoqB-2qykA:
82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qym PHOSPHODIESTERASE 4C

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 281
HIS A 282
ASP A 440
LEU A 441
PRO A 444
TYR A 451
TRP A 454
THR A 455
ILE A 458
PHE A 494
 None
None
ZN  A   1 (-2.5A)
None
None
None
None
None
None
None
 0.60A 1xoqB-2qymA:
43.4		 1xoqB-2qymA:
82.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		5 TYR A 680
HIS A 681
ASP A 835
TRP A 849
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
ZN  A   1 (-2.6A)
None
IBM  A   3 (-3.6A)
 0.42A 1xoqB-2r8qA:
39.4		 1xoqB-2r8qA:
30.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.6A)
 0.68A 1xoqB-3b2rA:
31.7		 1xoqB-3b2rA:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.7A)
 0.67A 1xoqB-3bjcA:
34.3		 1xoqB-3bjcA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpi RAB GDP-DISSOCIATION
INHIBITOR

(Saccharomyces
cerevisiae) 		PF00996
(GDI) 		5 LEU G 239
TYR G 415
THR G  20
ILE G  23
PHE G 421
 None
 1.45A 1xoqB-3cpiG:
undetectable		 1xoqB-3cpiG:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
hyorhinis) 		PF06646
(Mycoplasma_p37) 		5 ASP A 280
LEU A 277
ILE A 304
SER A 307
PHE A 306
 None
 1.39A 1xoqB-3e79A:
undetectable		 1xoqB-3e79A:
22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 555
HIS A 556
ASP A 726
PRO A 730
TRP A 740
ILE A 744
SER A 777
PHE A 781
 None
None
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
 0.37A 1xoqB-3ecnA:
45.0		 1xoqB-3ecnA:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs3 NUCLEOSOME ASSEMBLY
PROTEIN 1, PUTATIVE

(Plasmodium
falciparum) 		PF00956
(NAP) 		5 ASP A 121
LEU A 125
ILE A 188
SER A 161
PHE A 152
 None
 1.26A 1xoqB-3fs3A:
undetectable		 1xoqB-3fs3A:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		6 HIS A 326
ASP A 484
LEU A 485
MET A 523
SER A 534
PHE A 538
 D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
 0.90A 1xoqB-3g4gA:
52.7		 1xoqB-3g4gA:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 325
HIS A 326
ASP A 484
LEU A 485
PRO A 488
TYR A 495
TRP A 498
THR A 499
ILE A 502
MET A 523
PHE A 538
 None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
 0.49A 1xoqB-3g4gA:
52.7		 1xoqB-3g4gA:
81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyw NUCLEOSOME ASSEMBLY
PROTEIN 1, PUTATIVE

(Plasmodium
falciparum) 		PF00956
(NAP) 		5 ASP A 121
LEU A 125
ILE A 188
SER A 161
PHE A 152
 None
 1.20A 1xoqB-3gywA:
undetectable		 1xoqB-3gywA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoc FILAMIN-A

(Homo sapiens) 		PF00307
(CH) 		5 LEU A 172
THR A 186
ILE A 185
SER A 189
PHE A 188
 None
 1.32A 1xoqB-3hocA:
undetectable		 1xoqB-3hocA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hym ANAPHASE-PROMOTING
COMPLEX SUBUNIT
CDC26
CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG

(Homo sapiens;
Homo sapiens) 		PF10471
(ANAPC_CDC26)
PF13424
(TPR_12) 		5 LEU A   2
PRO B 335
TRP B 337
SER B 301
PHE B 303
 None
 1.45A 1xoqB-3hymA:
undetectable		 1xoqB-3hymA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		6 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
 None
None
ZN  A   1 (-2.7A)
None
None
None
 0.98A 1xoqB-3ibjA:
32.7		 1xoqB-3ibjA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE

(Pecten maximus) 		PF02317
(Octopine_DH) 		5 PRO B 145
THR B  89
ILE B  87
SER B 117
PHE B 141
 None
 1.41A 1xoqB-3iqdB:
undetectable		 1xoqB-3iqdB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4i UNCHARACTERIZED
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF03737
(RraA-like) 		5 ASP A 174
PRO A 134
TYR A 133
THR A 116
SER A  85
 None
 1.18A 1xoqB-3k4iA:
undetectable		 1xoqB-3k4iA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		5 ASP B 798
LEU B 799
THR B 807
MET B 499
SER B 456
 None
 1.33A 1xoqB-3k70B:
undetectable		 1xoqB-3k70B:
14.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		12 TYR A 233
HIS A 234
ASP A 392
LEU A 393
PRO A 396
TYR A 403
TRP A 406
THR A 407
ILE A 410
MET A 431
SER A 442
PHE A 446
 None
None
ZN  A   1 (-2.6A)
None
ZG2  A 506 ( 4.5A)
None
None
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.4A)
None
ZG2  A 506 (-3.6A)
 0.58A 1xoqB-3o57A:
51.8		 1xoqB-3o57A:
82.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
SER A 368
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
 0.49A 1xoqB-3sl5A:
53.4		 1xoqB-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.50A 1xoqB-3sl5A:
53.4		 1xoqB-3sl5A:
94.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 HIS A 150
ASP A  79
ILE A 152
SER A 272
PHE A 271
 None
ZN  A 600 (-2.5A)
None
None
None
 1.22A 1xoqB-3t3oA:
undetectable		 1xoqB-3t3oA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 524
HIS A 525
ASP A 674
LEU A 675
ILE A 692
PHE A 729
 C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
ZN  A 772 (-2.4A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
C1L  A   1 (-3.5A)
 0.90A 1xoqB-3ui7A:
38.5		 1xoqB-3ui7A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 524
HIS A 525
LEU A 635
ILE A 692
PHE A 729
 C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
None
C1L  A   1 (-4.3A)
C1L  A   1 (-3.5A)
 1.46A 1xoqB-3ui7A:
38.5		 1xoqB-3ui7A:
28.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		6 TYR A 367
HIS A 368
ASP A 521
TRP A 535
ILE A 538
PHE A 573
 WYQ  A 701 (-4.5A)
None
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.4A)
 0.71A 1xoqB-3v94A:
40.0		 1xoqB-3v94A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 ASP A 459
LEU A 460
ILE A 251
SER A 240
PHE A 471
 None
 1.37A 1xoqB-3vf1A:
undetectable		 1xoqB-3vf1A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 TYR A3601
LEU A3181
TYR A3233
THR A3237
ILE A3238
 None
 1.48A 1xoqB-3vkgA:
undetectable		 1xoqB-3vkgA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtc PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00106
(adh_short) 		5 LEU A  83
THR A 179
ILE A 137
SER A 176
PHE A 128
 None
 1.38A 1xoqB-3wtcA:
undetectable		 1xoqB-3wtcA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		5 LEU A 328
THR A 306
ILE A 320
SER A 343
PHE A 341
 None
None
None
SO4  A1418 ( 3.9A)
None
 1.47A 1xoqB-4d2jA:
undetectable		 1xoqB-4d2jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		5 HIS A  44
ASP A 145
LEU A 146
ILE A 149
SER A 139
 None
 1.34A 1xoqB-4dh2A:
undetectable		 1xoqB-4dh2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
 None
None
ZN  A1001 (-2.5A)
None
None
None
 0.66A 1xoqB-4htzA:
38.8		 1xoqB-4htzA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 655
LEU A 809
ILE A 826
MET A 847
PHE A 862
 None
 1.11A 1xoqB-4htzA:
38.8		 1xoqB-4htzA:
28.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		5 TYR A 668
HIS A 669
ASP A 822
TRP A 836
PHE A 877
 None
None
ZN  A1001 (-2.5A)
None
None
 0.47A 1xoqB-4i15A:
38.6		 1xoqB-4i15A:
32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		5 ASP A 372
LEU A 373
ILE A 269
SER A 390
PHE A 402
 EDO  A 510 (-2.9A)
None
None
None
None
 1.31A 1xoqB-4itaA:
undetectable		 1xoqB-4itaA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0w DNA REPAIR PROTEIN
RAD2

(Saccharomyces
cerevisiae) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 ASP A 815
LEU A 818
THR A 822
ILE A 824
SER A 842
 CA  A1001 (-3.5A)
None
None
None
None
 1.43A 1xoqB-4q0wA:
undetectable		 1xoqB-4q0wA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qp0 ENDO-BETA-MANNANASE

(Rhizomucor
miehei) 		PF00150
(Cellulase) 		5 LEU A  29
THR A 166
ILE A  93
SER A  98
PHE A  41
 None
 1.49A 1xoqB-4qp0A:
undetectable		 1xoqB-4qp0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 ASP A  24
LEU A  37
TYR A  11
ILE A 414
SER A  62
 None
 1.18A 1xoqB-4um8A:
undetectable		 1xoqB-4um8A:
18.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 603
SER A 614
PHE A 618
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
None
 0.73A 1xoqB-4wziA:
52.6		 1xoqB-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TYR A 575
TRP A 578
THR A 579
MET A 603
SER A 614
PHE A 618
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
None
 0.61A 1xoqB-4wziA:
52.6		 1xoqB-4wziA:
48.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		5 HIS A 104
ASP A 265
LEU A 266
THR A 182
PHE A 189
 None
 1.42A 1xoqB-4y9sA:
undetectable		 1xoqB-4y9sA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yge MULTIPLE COAGULATION
FACTOR DEFICIENCY
PROTEIN 2

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 ASP B  89
LEU B  91
THR B  98
ILE B  97
SER B 113
 CA  B 502 ( 4.7A)
None
None
None
None
 1.47A 1xoqB-4ygeB:
undetectable		 1xoqB-4ygeB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		5 HIS B  54
LEU B 126
TYR B 131
THR B  60
ILE B  59
 None
 1.14A 1xoqB-4z0xB:
undetectable		 1xoqB-4z0xB:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 222
HIS A 223
ASP A 370
PRO A 374
TRP A 384
THR A 385
SER A 420
PHE A 424
 None
4QJ  A 603 ( 4.9A)
ZN  A 601 (-2.5A)
None
None
None
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.5A)
 0.47A 1xoqB-5b25A:
44.0		 1xoqB-5b25A:
38.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dc4 AS25 MONOBODY

(Homo sapiens) 		PF00041
(fn3) 		5 PRO B  27
TRP B  24
THR B   8
ILE B  89
SER B   4
 None
 1.35A 1xoqB-5dc4B:
undetectable		 1xoqB-5dc4B:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzs SHIKIMATE
DEHYDROGENASE
(NADP(+))

(Clostridioides
difficile) 		PF08501
(Shikimate_dh_N) 		5 HIS A  20
LEU A 264
TYR A 234
ILE A 241
SER A 255
 None
 1.41A 1xoqB-5dzsA:
undetectable		 1xoqB-5dzsA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3y ADENYLATE KINSE

(synthetic
construct) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 TYR A 186
ASP A  97
ILE A   4
SER A  30
PHE A  86
 None
None
None
ADP  A1216 ( 4.8A)
ADP  A1216 (-4.8A)
 1.49A 1xoqB-5g3yA:
undetectable		 1xoqB-5g3yA:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 5 TYR A 668
HIS A 669
ASP A 823
TRP A 837
PHE A 878
 LLN  A1003 ( 4.8A)
None
ZN  A1001 (-2.6A)
None
LLN  A1003 (-3.8A)
 0.33A 1xoqB-5h2rA:
39.2		 1xoqB-5h2rA:
32.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 HIS A 148
ASP A 189
LEU A 220
ILE A 127
MET A  36
 None
 1.34A 1xoqB-5h42A:
undetectable		 1xoqB-5h42A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in7 NEURONAL MIGRATION
PROTEIN DOUBLECORTIN

(Homo sapiens) 		PF03607
(DCX) 		5 ASP A 167
LEU A 164
ILE A 149
SER A 205
PHE A 138
 None
 1.35A 1xoqB-5in7A:
undetectable		 1xoqB-5in7A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 ASP A  24
LEU A  37
TYR A  11
ILE A 414
SER A  62
 None
 0.96A 1xoqB-5neuA:
undetectable		 1xoqB-5neuA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 11 TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TYR A 575
TRP A 578
THR A 579
ILE A 582
SER A 614
PHE A 618
 None
None
ZN  A 699 ( 2.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
 0.15A 1xoqB-5ohjA:
51.9		 1xoqB-5ohjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 9 TYR A 405
LEU A 565
PRO A 568
TYR A 575
TRP A 578
THR A 579
ILE A 582
MET A 603
PHE A 618
 None
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.9A)
 0.55A 1xoqB-5ohjA:
51.9		 1xoqB-5ohjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5op0 DNA POLYMERASE LIGD,
POLYMERASE DOMAIN

(Mycolicibacterium
smegmatis) 		no annotation 5 TYR B  74
ASP B 238
PRO B 123
THR B 120
SER B 176
 None
 1.22A 1xoqB-5op0B:
undetectable		 1xoqB-5op0B:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 LEU A 341
TYR A 294
ILE A 348
SER A 206
PHE A 155
 None
 1.24A 1xoqB-5u09A:
undetectable		 1xoqB-5u09A:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta) 		no annotation 5 HIS A  83
ASP A 236
LEU A 237
PRO A 240
PHE A 291
 None
ZN  A 401 (-2.4A)
None
None
None
 0.53A 1xoqB-5vydA:
40.0		 1xoqB-5vydA:
32.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta) 		no annotation 5 HIS A  83
ASP A 236
LEU A 237
TRP A 250
PHE A 291
 None
ZN  A 401 (-2.4A)
None
None
None
 0.68A 1xoqB-5vydA:
40.0		 1xoqB-5vydA:
32.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 9 HIS A 160
LEU A 319
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
SER A 368
 None
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.8A)
None
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-2.5A)
 0.65A 1xoqB-5wh6A:
55.1		 1xoqB-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 11 TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
PHE A 372
 AKJ  A 601 ( 4.7A)
None
ZN  A 602 (-2.5A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.8A)
None
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-4.1A)
 0.42A 1xoqB-5wh6A:
55.1		 1xoqB-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 5 PRO A  99
TYR A  69
THR A 110
ILE A  83
SER A  92
 None
 1.08A 1xoqB-5xjhA:
undetectable		 1xoqB-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 5 PRO A  99
TYR A  69
THR A 110
ILE A  83
SER A  93
 None
 1.33A 1xoqB-5xjhA:
undetectable		 1xoqB-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ane POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 5 PRO A  72
TYR A  42
THR A  83
ILE A  56
SER A  65
 None
 1.06A 1xoqB-6aneA:
undetectable		 1xoqB-6aneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ane POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE

(Ideonella
sakaiensis) 		no annotation 5 PRO A  72
TYR A  42
THR A  83
ILE A  56
SER A  66
 None
 1.33A 1xoqB-6aneA:
undetectable		 1xoqB-6aneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ASP A  98
LEU A  96
TYR A  45
THR A  49
ILE A  55
 None
 1.37A 1xoqB-6f8zA:
undetectable		 1xoqB-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 5 LEU A 832
TYR A 997
THR A1001
SER A 695
PHE A 696
 None
 1.12A 1xoqB-6fn1A:
undetectable		 1xoqB-6fn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 MET A  43
ASN A 235
GLN A 291
 None
GLC  A 501 (-3.8A)
GLC  A 501 ( 4.2A)
 1.03A 1xoqB-1bdgA:
undetectable		 1xoqB-1bdgA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og6 HYPOTHETICAL
OXIDOREDUCTASE YDHF

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		3 MET A 134
ASN A 179
GLN A 198
 None
 0.95A 1xoqB-1og6A:
undetectable		 1xoqB-1og6A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfv PYRIDOXAL KINASE

(Ovis aries) 		PF08543
(Phos_pyr_kin) 		3 MET A 221
ASN A 251
GLN A 205
 None
 0.94A 1xoqB-1rfvA:
undetectable		 1xoqB-1rfvA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjy SUGAR TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		3 MET A 139
ASN A 129
GLN A 271
 None
 0.88A 1xoqB-1tjyA:
undetectable		 1xoqB-1tjyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		3 MET A 129
ASN A 334
GLN A 140
 None
 0.90A 1xoqB-1uc4A:
undetectable		 1xoqB-1uc4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT
BIPHENYL DIOXYGENASE
SMALL SUBUNIT

(Rhodococcus
jostii;
Rhodococcus
jostii) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		3 MET A  82
ASN A 112
GLN B  70
 None
 1.01A 1xoqB-1uliA:
undetectable		 1xoqB-1uliA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE

(Pseudoalteromonas
sp. AS-11) 		PF00082
(Peptidase_S8)
PF02225
(PA) 		3 MET A 370
ASN A 235
GLN A 285
 None
 1.05A 1xoqB-1v6cA:
undetectable		 1xoqB-1v6cA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF00291
(PALP) 		3 MET A  96
ASN A  72
GLN A 141
 None
PLP  A 413 (-3.6A)
None
 0.73A 1xoqB-1ve1A:
undetectable		 1xoqB-1ve1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5y YKUV PROTEIN

(Bacillus
subtilis) 		PF00578
(AhpC-TSA) 		3 MET A 133
ASN A  52
GLN A  92
 None
 0.89A 1xoqB-2b5yA:
undetectable		 1xoqB-2b5yA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqg TAR DNA-BINDING
PROTEIN-43

(Homo sapiens) 		PF00076
(RRM_1) 		3 MET A 162
ASN A 179
GLN A 182
 None
 1.01A 1xoqB-2cqgA:
undetectable		 1xoqB-2cqgA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		3 MET A 329
ASN A 301
GLN A 261
 None
 1.05A 1xoqB-2e28A:
undetectable		 1xoqB-2e28A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi8 SULFATASE-MODIFYING
FACTOR 1

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		3 MET X 161
ASN X 259
GLN X 262
 None
CA  X1017 (-3.3A)
CA  X1017 (-4.1A)
 0.93A 1xoqB-2hi8X:
undetectable		 1xoqB-2hi8X:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jep XYLOGLUCANASE

(Paenibacillus
pabuli) 		PF00150
(Cellulase) 		3 MET A 180
ASN A 146
GLN A 150
 None
 1.05A 1xoqB-2jepA:
undetectable		 1xoqB-2jepA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 MET A 491
ASN A 683
GLN A 739
 None
GLC  A1003 (-3.6A)
GLC  A1003 (-4.3A)
 0.82A 1xoqB-2nztA:
undetectable		 1xoqB-2nztA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 MET A  84
ASN A  99
GLN A  58
 None
None
HEM  A 502 (-4.2A)
 1.03A 1xoqB-2qjpA:
undetectable		 1xoqB-2qjpA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		3 MET A 485
ASN A 533
GLN A 581
 None
NPV  A   3 (-4.4A)
NPV  A   3 (-3.1A)
 0.32A 1xoqB-2qykA:
51.9		 1xoqB-2qykA:
82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		3 MET A 797
ASN A 838
GLN A 887
 None
IBM  A   3 (-4.5A)
IBM  A   3 (-3.3A)
 0.58A 1xoqB-2r8qA:
39.4		 1xoqB-2r8qA:
30.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzn VENOM ALLERGEN 3

(Solenopsis
invicta) 		PF00188
(CAP) 		3 MET A 131
ASN A  35
GLN A  90
 None
 0.81A 1xoqB-2vznA:
undetectable		 1xoqB-2vznA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 AP-2 COMPLEX SUBUNIT
BETA

(Homo sapiens) 		PF01602
(Adaptin_N) 		3 MET B 110
ASN B  89
GLN B  59
 None
 1.00A 1xoqB-2xa7B:
undetectable		 1xoqB-2xa7B:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yiu CYTOCHROME B

(Paracoccus
denitrificans) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 MET A  84
ASN A  99
GLN A  58
 None
None
HEM  A 500 (-4.4A)
 0.95A 1xoqB-2yiuA:
undetectable		 1xoqB-2yiuA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwu OUTER MEMBRANE USHER
PROTEIN FIMD,
N-TERMINAL DOMAIN

(Escherichia
coli) 		PF13954
(PapC_N) 		3 MET D  44
ASN D 122
GLN D 117
 None
 0.92A 1xoqB-3bwuD:
undetectable		 1xoqB-3bwuD:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		3 MET A 168
ASN A 251
GLN A 322
 None
 0.82A 1xoqB-3cf4A:
undetectable		 1xoqB-3cf4A:
16.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		3 MET A 670
ASN A 729
GLN A 778
 IBM  A   3 (-4.5A)
None
IBM  A   3 (-3.4A)
 0.34A 1xoqB-3ecnA:
45.0		 1xoqB-3ecnA:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoe PYRUVATE KINASE

(Toxoplasma
gondii) 		PF00224
(PK)
PF02887
(PK_C) 		3 MET A 363
ASN A 335
GLN A 295
 None
 1.03A 1xoqB-3eoeA:
undetectable		 1xoqB-3eoeA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhx PYRIDOXAL KINASE

(Homo sapiens) 		PF08543
(Phos_pyr_kin) 		3 MET A 221
ASN A 251
GLN A 205
 None
 0.97A 1xoqB-3fhxA:
undetectable		 1xoqB-3fhxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy6 INTEGRON CASSETTE
PROTEIN

(Vibrio cholerae) 		no annotation 3 MET A  28
ASN A  71
GLN A  55
 None
 0.91A 1xoqB-3fy6A:
undetectable		 1xoqB-3fy6A:
17.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		3 MET A 439
ASN A 487
GLN A 535
 D71  A 901 ( 4.0A)
D71  A 901 (-4.5A)
D71  A 901 (-3.1A)
 0.58A 1xoqB-3g4gA:
52.7		 1xoqB-3g4gA:
81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1v GLUCOKINASE

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 MET X  37
ASN X 231
GLN X 287
 None
GLC  X 500 (-3.8A)
GLC  X 500 (-4.2A)
 0.90A 1xoqB-3h1vX:
undetectable		 1xoqB-3h1vX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 MET A 673
ASN A 663
GLN A 527
 None
 1.06A 1xoqB-3hhsA:
undetectable		 1xoqB-3hhsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 MET A 646
ASN A 739
GLN B 662
 None
 1.05A 1xoqB-3hkzA:
undetectable		 1xoqB-3hkzA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm8 HEXOKINASE-3

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 MET A 504
ASN A 689
GLN A 745
 None
GLC  A1001 (-3.8A)
GLC  A1001 (-3.8A)
 0.93A 1xoqB-3hm8A:
undetectable		 1xoqB-3hm8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju7 PUTATIVE
PLP-DEPENDENT
AMINOTRANSFERASE

(Bacillus cereus) 		PF01041
(DegT_DnrJ_EryC1) 		3 MET A 246
ASN A  51
GLN A 176
 None
 1.00A 1xoqB-3ju7A:
undetectable		 1xoqB-3ju7A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv0 HET-C2

(Podospora
anserina) 		PF08718
(GLTP) 		3 MET A  51
ASN A 124
GLN A 180
 None
 1.06A 1xoqB-3kv0A:
undetectable		 1xoqB-3kv0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis) 		PF00590
(TP_methylase) 		3 MET A  28
ASN A  49
GLN A  63
 None
 1.04A 1xoqB-3kwpA:
undetectable		 1xoqB-3kwpA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Mus musculus) 		PF00079
(Serpin) 		3 MET A  62
ASN A 167
GLN A 322
 None
 1.02A 1xoqB-3lw2A:
undetectable		 1xoqB-3lw2A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		3 MET B 320
ASN B 335
GLN B 331
 None
 0.91A 1xoqB-3ml0B:
undetectable		 1xoqB-3ml0B:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		3 MET A 365
ASN A 405
GLN A 453
 None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.5A)
 0.88A 1xoqB-3n3zA:
41.3		 1xoqB-3n3zA:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1h PERIPLASMIC PROTEIN
TORT

(Vibrio
parahaemolyticus) 		PF00532
(Peripla_BP_1) 		3 MET B  52
ASN B 120
GLN B  77
 None
TMO  B   1 ( 4.5A)
None
 0.96A 1xoqB-3o1hB:
undetectable		 1xoqB-3o1hB:
26.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		3 MET A 347
ASN A 395
GLN A 443
 ZG2  A 506 (-3.9A)
ZG2  A 506 (-4.3A)
ZG2  A 506 (-3.3A)
 0.29A 1xoqB-3o57A:
51.8		 1xoqB-3o57A:
82.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ono RIBOSE/GALACTOSE
ISOMERASE

(Vibrio
parahaemolyticus) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		3 MET A   1
ASN A 106
GLN A 103
 None
 0.98A 1xoqB-3onoA:
undetectable		 1xoqB-3onoA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		3 MET A  46
ASN A 164
GLN A  26
 None
 1.04A 1xoqB-3q9oA:
undetectable		 1xoqB-3q9oA:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		3 MET A 273
ASN A 321
GLN A 369
 MET  A 273 (-0.0A)
ASN  A 321 (-0.6A)
GLN  A 369 (-0.6A)
 0.31A 1xoqB-3sl5A:
53.4		 1xoqB-3sl5A:
94.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 MET A 356
ASN A 222
GLN A 204
 None
 0.89A 1xoqB-3snxA:
undetectable		 1xoqB-3snxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swh PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF10540
(Membr_traf_MHD) 		3 MET A1231
ASN A1210
GLN A1208
 None
 0.94A 1xoqB-3swhA:
undetectable		 1xoqB-3swhA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		3 MET A 138
ASN A 128
GLN A 270
 None
 0.96A 1xoqB-3t95A:
undetectable		 1xoqB-3t95A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr9 DIHYDROPTEROATE
SYNTHASE

(Coxiella
burnetii) 		PF00809
(Pterin_bind) 		3 MET A 240
ASN A 206
GLN A 132
 PT1  A1001 ( 4.2A)
None
PT1  A1001 ( 3.4A)
 1.01A 1xoqB-3tr9A:
undetectable		 1xoqB-3tr9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trj PHOSPHOHEPTOSE
ISOMERASE

(Francisella
tularensis) 		PF13580
(SIS_2) 		3 MET A 155
ASN A 126
GLN A  99
 None
 0.98A 1xoqB-3trjA:
undetectable		 1xoqB-3trjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE

(Agrobacterium
fabrum) 		PF13407
(Peripla_BP_4) 		3 MET A 175
ASN A 108
GLN A 241
 None
None
BDP  A 331 ( 4.1A)
 1.04A 1xoqB-3uugA:
undetectable		 1xoqB-3uugA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8b PUTATIVE
DEHYDROGENASE,
POSSIBLY
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		3 MET A  69
ASN A  89
GLN A 164
 None
 0.98A 1xoqB-3v8bA:
undetectable		 1xoqB-3v8bA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E

(Homo sapiens) 		PF00067
(p450) 		3 MET A 435
ASN A  81
GLN A  60
 None
SO4  A 603 (-3.7A)
None
 0.92A 1xoqB-3v8dA:
undetectable		 1xoqB-3v8dA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE

(Xenopus laevis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 MET A  30
ASN A 224
GLN A 280
 None
 0.89A 1xoqB-3w0lA:
undetectable		 1xoqB-3w0lA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zei O-ACETYLSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		3 MET A  98
ASN A  74
GLN A 144
 None
PLP  A1301 (-3.8A)
AWH  A1302 (-3.3A)
 0.90A 1xoqB-3zeiA:
undetectable		 1xoqB-3zeiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00291
(PALP) 		3 MET A 209
ASN A 185
GLN A 255
 None
PLP  A 500 (-3.8A)
None
 0.82A 1xoqB-4aecA:
undetectable		 1xoqB-4aecA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 MET B 351
ASN B 317
GLN B 323
 MOA  B1526 ( 4.7A)
MOA  B1526 ( 3.6A)
None
 1.01A 1xoqB-4af0B:
undetectable		 1xoqB-4af0B:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 MET A1486
ASN A1412
GLN A1469
 None
 0.92A 1xoqB-4bedA:
undetectable		 1xoqB-4bedA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		3 MET A 274
ASN A  39
GLN A  71
 None
XYP  A1003 (-3.3A)
None
 1.03A 1xoqB-4c1tA:
undetectable		 1xoqB-4c1tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		3 MET A 239
ASN A  86
GLN A 187
 None
 0.82A 1xoqB-4cyfA:
undetectable		 1xoqB-4cyfA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 MET A  26
ASN A 109
GLN A 156
 None
 1.06A 1xoqB-4dpkA:
undetectable		 1xoqB-4dpkA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwe UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15421
(Polysacc_deac_3) 		3 MET A 420
ASN A 447
GLN A 155
 None
 1.03A 1xoqB-4dweA:
undetectable		 1xoqB-4dweA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5v PUTATIVE THUA-LIKE
PROTEIN

(Parabacteroides
merdae) 		PF06283
(ThuA) 		3 MET A 260
ASN A  37
GLN A  42
 None
 1.03A 1xoqB-4e5vA:
undetectable		 1xoqB-4e5vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 MET A 491
ASN A 683
GLN A 739
 None
BGC  A1003 (-3.9A)
BGC  A1003 (-4.4A)
 0.78A 1xoqB-4f9oA:
undetectable		 1xoqB-4f9oA:
16.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		3 MET A 785
ASN A 825
GLN A 874
 None
 0.69A 1xoqB-4i15A:
38.7		 1xoqB-4i15A:
32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 MET A  81
ASN A  85
GLN A  65
 None
 1.05A 1xoqB-4jznA:
undetectable		 1xoqB-4jznA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		3 MET A 287
ASN A  28
GLN A 316
 None
 0.92A 1xoqB-4kdsA:
undetectable		 1xoqB-4kdsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5n URACIL-DNA
GLYCOSYLASE
EARLY PROTEIN GP1B

(Human
alphaherpesvirus
1;
Bacillus virus
phi29) 		PF03167
(UDG)
no annotation 		3 MET C  14
ASN C  42
GLN A  95
 None
ACT  A 301 ( 4.9A)
None
 1.04A 1xoqB-4l5nC:
undetectable		 1xoqB-4l5nC:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 MET A 177
ASN A 210
GLN A 599
 None
 1.05A 1xoqB-4lglA:
undetectable		 1xoqB-4lglA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		3 MET X  96
ASN X  72
GLN X 143
 None
LLP  X  42 ( 3.8A)
LLP  X  42 ( 4.9A)
 0.92A 1xoqB-4li3X:
undetectable		 1xoqB-4li3X:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 MET A 359
ASN A  70
GLN A 381
 None
 0.99A 1xoqB-4mmoA:
undetectable		 1xoqB-4mmoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		3 MET A  54
ASN A  44
GLN A  16
 None
 1.04A 1xoqB-4mnpA:
undetectable		 1xoqB-4mnpA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 MET A  62
ASN A 256
GLN A 312
 None
BGC  A 501 (-3.7A)
BGC  A 501 ( 4.4A)
 0.77A 1xoqB-4qs9A:
undetectable		 1xoqB-4qs9A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		3 MET A 134
ASN A 179
GLN A 198
 None
 0.86A 1xoqB-4r9oA:
undetectable		 1xoqB-4r9oA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II

(Staphylococcus
aureus) 		PF01116
(F_bP_aldolase) 		3 MET A  57
ASN A 233
GLN A  22
 None
FLC  A 302 (-4.2A)
None
 1.06A 1xoqB-4to8A:
undetectable		 1xoqB-4to8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR

(Bacillus
subtilis) 		PF00155
(Aminotran_1_2)
PF00392
(GntR) 		3 MET A 200
ASN A 214
GLN A 186
 None
 1.03A 1xoqB-4tv7A:
undetectable		 1xoqB-4tv7A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN

(Haliangium
ochraceum) 		PF14497
(GST_C_3) 		3 MET A 222
ASN A 118
GLN A 130
 None
 1.01A 1xoqB-4w66A:
undetectable		 1xoqB-4w66A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
BETA

(Synanceia
horrida) 		PF00622
(SPRY)
PF13765
(PRY) 		3 MET B  69
ASN B  95
GLN B  96
 None
 1.05A 1xoqB-4wvmB:
undetectable		 1xoqB-4wvmB:
17.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		3 MET A 519
ASN A 567
GLN A 615
 None
 0.43A 1xoqB-4wziA:
52.6		 1xoqB-4wziA:
48.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP

(Pseudomonas
putida) 		PF03480
(DctP) 		3 MET A 265
ASN A 326
GLN A 330
 None
 0.78A 1xoqB-4xfeA:
undetectable		 1xoqB-4xfeA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN

(Bacillus
thuringiensis) 		no annotation 3 MET A 134
ASN A 194
GLN A 415
 None
 1.06A 1xoqB-4xhpA:
undetectable		 1xoqB-4xhpA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris) 		PF00759
(Glyco_hydro_9) 		3 MET A 237
ASN A 272
GLN A 246
 None
 0.99A 1xoqB-4zg8A:
undetectable		 1xoqB-4zg8A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dvj BINDING PROTEIN
COMPONENT OF ABC
SUGAR TRANSPORTER

(Pseudomonas
putida) 		PF01547
(SBP_bac_1) 		3 MET A 129
ASN A 141
GLN A 332
 None
 1.01A 1xoqB-5dvjA:
undetectable		 1xoqB-5dvjA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 MET A 753
ASN A 436
GLN A1235
 FES  A3001 (-4.9A)
None
None
 1.03A 1xoqB-5epgA:
undetectable		 1xoqB-5epgA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 MET A 409
ASN A 211
GLN A 456
 None
 1.02A 1xoqB-5fl7A:
undetectable		 1xoqB-5fl7A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 MET B 753
ASN B  98
GLN B  72
 None
 0.88A 1xoqB-5fq6B:
undetectable		 1xoqB-5fq6B:
15.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 3 MET A 785
ASN A 826
GLN A 875
 LLN  A1003 (-4.0A)
LLN  A1003 (-4.4A)
LLN  A1003 (-3.0A)
 0.40A 1xoqB-5h2rA:
39.2		 1xoqB-5h2rA:
32.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h60 TRANSFERASE

(Escherichia
coli) 		no annotation 3 MET A 276
ASN A 256
GLN A  50
 None
None
UDP  A 401 (-4.6A)
 1.04A 1xoqB-5h60A:
undetectable		 1xoqB-5h60A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkj ESTERASE E22

(uncultured
bacterium) 		PF00561
(Abhydrolase_1) 		3 MET A 358
ASN A 320
GLN A 203
 None
 0.81A 1xoqB-5jkjA:
undetectable		 1xoqB-5jkjA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		3 MET A 341
ASN A 331
GLN A 327
 None
 0.93A 1xoqB-5l8sA:
undetectable		 1xoqB-5l8sA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2
POLYCOMB PROTEIN
SUZ12

(Homo sapiens;
Homo sapiens) 		PF00856
(SET)
PF11616
(EZH2_WD-Binding)
PF09733
(VEFS-Box) 		3 MET A 439
ASN C 651
GLN C 685
 None
 0.98A 1xoqB-5ls6A:
undetectable		 1xoqB-5ls6A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		3 MET A 313
ASN A 218
GLN A 256
 ARG  A 403 ( 4.6A)
None
None
 0.97A 1xoqB-5lunA:
undetectable		 1xoqB-5lunA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m28 MALE1

(Lactobacillus
casei) 		PF13416
(SBP_bac_8) 		3 MET A 120
ASN A 105
GLN A 300
 None
 0.89A 1xoqB-5m28A:
undetectable		 1xoqB-5m28A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncs SERPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		3 MET A 231
ASN A 378
GLN A 247
 None
 0.88A 1xoqB-5ncsA:
undetectable		 1xoqB-5ncsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 3 MET A 519
ASN A 567
GLN A 615
 9VE  A 801 (-3.8A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.2A)
 0.31A 1xoqB-5ohjA:
51.9		 1xoqB-5ohjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 3 MET A 273
ASN A 321
GLN A 369
 AKJ  A 601 ( 3.9A)
AKJ  A 601 (-4.3A)
AKJ  A 601 (-3.0A)
 0.11A 1xoqB-5wh6A:
55.1		 1xoqB-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa2 CYSTEINE SYNTHASE

(Planctopirus
limnophila) 		PF00291
(PALP) 		3 MET A  98
ASN A  74
GLN A 143
 None
LLP  A  44 ( 3.8A)
LLP  A  44 ( 4.8A)
 0.71A 1xoqB-5xa2A:
undetectable		 1xoqB-5xa2A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7f UGGT

(Thermomyces
dupontii) 		PF01501
(Glyco_transf_8) 		3 MET A1321
ASN A1431
GLN A1445
 None
 0.98A 1xoqB-5y7fA:
undetectable		 1xoqB-5y7fA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygu DIAMINOPIMELATE
EPIMERASE

(Escherichia
coli) 		no annotation 3 MET A 118
ASN A  11
GLN A  44
 None
IOD  A 308 (-4.5A)
None
 0.71A 1xoqB-5yguA:
undetectable		 1xoqB-5yguA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT

(Thermococcus
kodakarensis) 		no annotation 3 MET A 269
ASN A 307
GLN A 204
 None
 1.01A 1xoqB-5yy0A:
undetectable		 1xoqB-5yy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN

(Bordetella
bronchiseptica) 		no annotation 3 MET A 584
ASN A 547
GLN A 564
 None
 0.86A 1xoqB-6au1A:
undetectable		 1xoqB-6au1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-4

(Rattus
norvegicus) 		no annotation 3 MET 7  70
ASN 7  90
GLN 7 113
 None
 1.03A 1xoqB-6epd7:
undetectable		 1xoqB-6epd7:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 3 MET A 439
ASN A 232
GLN A 288
 None
MG  A2001 ( 4.5A)
None
 1.05A 1xoqB-6fsaA:
undetectable		 1xoqB-6fsaA:
undetectable