SIMILAR PATTERNS OF AMINO ACIDS FOR 1XLX_B_CIOB102_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 736
HIS A 737
HIS A 825
THR A 952
ILE A 955
PHE A 959
GLN A 988
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
 0.53A 1xlxB-1sojA:
41.8		 1xlxB-1sojA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 211
HIS A 212
HIS A 256
PHE A 384
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.53A 1xlxB-1zklA:
45.1		 1xlxB-1zklA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 412
MET A 485
THR A 545
GLN A 581
PHE A 584
 ZN  A   1 (-3.3A)
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
 1.45A 1xlxB-2qykA:
52.4		 1xlxB-2qykA:
87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 371
HIS A 372
HIS A 416
MET A 485
THR A 545
ILE A 548
MET A 549
PHE A 552
MET A 569
GLN A 581
PHE A 584
 NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.8A)
NPV  A   3 ( 4.7A)
NPV  A   3 (-4.8A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
 0.38A 1xlxB-2qykA:
52.4		 1xlxB-2qykA:
87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 371
HIS A 372
HIS A 416
MET A 485
THR A 545
ILE A 548
MET A 549
PHE A 552
MET A 569
SER A 580
PHE A 584
 NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.8A)
NPV  A   3 ( 4.7A)
NPV  A   3 (-4.8A)
NPV  A   3 (-3.1A)
NPV  A   3 (-4.5A)
NPV  A   3 (-3.3A)
 0.54A 1xlxB-2qykA:
52.4		 1xlxB-2qykA:
87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qym PHOSPHODIESTERASE 4C

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 281
HIS A 282
HIS A 326
MET A 395
THR A 455
ILE A 458
PHE A 494
 None
 0.47A 1xlxB-2qymA:
43.4		 1xlxB-2qymA:
75.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		7 TYR A 680
HIS A 681
HIS A 725
MET A 797
PHE A 857
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
None
IBM  A   3 (-4.9A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.55A 1xlxB-2r8qA:
39.7		 1xlxB-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		5 TYR A 680
HIS A 681
HIS A 725
MET A 797
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
None
None
 1.49A 1xlxB-2r8qA:
39.7		 1xlxB-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		6 TYR A 680
HIS A 681
MET A 797
MET A 874
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
IBM  A   3 ( 3.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.83A 1xlxB-2r8qA:
39.7		 1xlxB-2r8qA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 HIS A 228
MET A 277
ILE A 295
GLN A 443
PHE A 287
 None
 1.43A 1xlxB-2xf2A:
undetectable		 1xlxB-2xf2A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		5 HIS A 584
THR A 681
PHE A 678
SER A 361
PHE A 357
 None
 1.30A 1xlxB-2xsgA:
undetectable		 1xlxB-2xsgA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 612
HIS A 613
HIS A 657
PHE A 786
GLN A 817
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
None
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
 0.84A 1xlxB-3b2rA:
30.8		 1xlxB-3b2rA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 612
HIS A 613
HIS A 657
PHE A 786
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
MG  A 877 (-4.3A)
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.52A 1xlxB-3bjcA:
33.5		 1xlxB-3bjcA:
17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 556
HIS A 600
ILE A 744
SER A 777
PHE A 781
 None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
 0.69A 1xlxB-3ecnA:
44.9		 1xlxB-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 555
HIS A 556
HIS A 600
MET A 670
ILE A 744
GLN A 778
PHE A 781
 None
None
None
IBM  A   3 (-4.5A)
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.33A 1xlxB-3ecnA:
44.9		 1xlxB-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 325
HIS A 326
HIS A 370
THR A 499
ILE A 502
MET A 503
PHE A 506
MET A 523
SER A 534
GLN A 535
 None
D71  A 901 (-4.5A)
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
 0.70A 1xlxB-3g4gA:
51.1		 1xlxB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 325
HIS A 326
HIS A 370
THR A 499
ILE A 502
MET A 503
PHE A 506
SER A 534
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.44A 1xlxB-3g4gA:
51.1		 1xlxB-3g4gA:
66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 325
HIS A 370
MET A 439
THR A 499
ILE A 502
MET A 503
PHE A 506
SER A 534
GLN A 535
PHE A 538
 None
None
D71  A 901 ( 4.0A)
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-4.8A)
D71  A 901 (-3.4A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.62A 1xlxB-3g4gA:
51.1		 1xlxB-3g4gA:
66.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbn UDP-SUGAR HYDROLASE

(Campylobacter
jejuni) 		no annotation 5 HIS A 281
HIS A 280
THR A 167
ILE A 169
SER A  10
 None
 1.43A 1xlxB-3hbnA:
undetectable		 1xlxB-3hbnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		6 TYR A 655
HIS A 656
HIS A 700
ILE A 826
GLN A 859
PHE A 862
 None
 0.68A 1xlxB-3ibjA:
32.4		 1xlxB-3ibjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		no annotation 5 TYR K 493
THR K 450
PHE K 363
GLN K 447
PHE K 406
 None
 1.45A 1xlxB-3jblK:
undetectable		 1xlxB-3jblK:
19.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 252
HIS A 296
MET A 365
GLN A 453
PHE A 456
 None
None
None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
 0.57A 1xlxB-3n3zA:
40.8		 1xlxB-3n3zA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 292
MET A 365
PHE A 251
GLN A 453
PHE A 456
 ZN  A 507 (-3.5A)
None
IBM  A   1 ( 4.9A)
IBM  A   1 (-3.5A)
IBM  A   1 (-3.4A)
 1.30A 1xlxB-3n3zA:
40.8		 1xlxB-3n3zA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 274
MET A 347
THR A 407
GLN A 443
PHE A 446
 ZN  A   1 (-3.3A)
ZG2  A 506 (-3.9A)
ZG2  A 506 (-4.3A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
 1.47A 1xlxB-3o57A:
53.5		 1xlxB-3o57A:
93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 233
HIS A 234
HIS A 278
MET A 347
THR A 407
ILE A 410
MET A 411
PHE A 414
MET A 431
GLN A 443
PHE A 446
 None
None
None
ZG2  A 506 (-3.9A)
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
None
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.4A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
 0.59A 1xlxB-3o57A:
53.5		 1xlxB-3o57A:
93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 233
HIS A 234
HIS A 278
MET A 347
THR A 407
ILE A 410
MET A 411
PHE A 414
MET A 431
SER A 442
PHE A 446
 None
None
None
ZG2  A 506 (-3.9A)
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
None
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.4A)
None
ZG2  A 506 (-3.6A)
 0.70A 1xlxB-3o57A:
53.5		 1xlxB-3o57A:
93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 159
HIS A 160
HIS A 204
MET A 273
ILE A 336
MET A 337
PHE A 340
MET A 357
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
HIS  A 204 ( 1.0A)
MET  A 273 (-0.0A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.74A 1xlxB-3sl5A:
51.1		 1xlxB-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 159
HIS A 160
HIS A 204
MET A 273
THR A 333
ILE A 336
MET A 337
PHE A 340
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
HIS  A 204 ( 1.0A)
MET  A 273 (-0.0A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.54A 1xlxB-3sl5A:
51.1		 1xlxB-3sl5A:
84.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufk UNDA

(Shewanella sp.
HRCR_06) 		PF13435
(Cytochrome_C554) 		5 HIS A 755
ILE A 724
MET A 723
PHE A 720
PHE A 663
 HEC  A 909 (-3.1A)
HEC  A 909 ( 3.8A)
HEC  A 908 ( 3.7A)
HEC  A 909 (-4.4A)
HEC  A 908 ( 4.0A)
 1.26A 1xlxB-3ufkA:
undetectable		 1xlxB-3ufkA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 524
HIS A 525
HIS A 567
ILE A 692
PHE A 696
GLN A 726
PHE A 729
 C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
None
C1L  A   1 (-4.3A)
C1L  A   1 ( 4.7A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
 0.68A 1xlxB-3ui7A:
38.0		 1xlxB-3ui7A:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 524
ILE A 692
MET A 713
GLN A 726
PHE A 729
 C1L  A   1 ( 4.8A)
C1L  A   1 (-4.3A)
C1L  A   1 (-3.7A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
 1.19A 1xlxB-3ui7A:
38.0		 1xlxB-3ui7A:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		8 TYR A 367
HIS A 368
HIS A 413
MET A 482
ILE A 538
PHE A 542
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.77A 1xlxB-3v94A:
39.9		 1xlxB-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 655
HIS A 656
HIS A 700
ILE A 826
PHE A 830
GLN A 859
PHE A 862
 None
 0.42A 1xlxB-4htzA:
38.6		 1xlxB-4htzA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 655
ILE A 826
MET A 847
GLN A 859
PHE A 862
 None
 0.89A 1xlxB-4htzA:
38.6		 1xlxB-4htzA:
27.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		8 TYR A 668
HIS A 669
HIS A 713
MET A 785
PHE A 844
MET A 861
GLN A 874
PHE A 877
 None
 0.84A 1xlxB-4i15A:
38.8		 1xlxB-4i15A:
31.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		9 TYR A 405
HIS A 406
HIS A 450
ILE A 582
MET A 583
PHE A 586
MET A 603
SER A 614
GLN A 615
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
 1.05A 1xlxB-4wziA:
52.3		 1xlxB-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 405
HIS A 406
HIS A 450
MET A 519
ILE A 582
MET A 583
PHE A 586
SER A 614
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
 0.88A 1xlxB-4wziA:
52.3		 1xlxB-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 405
HIS A 406
HIS A 450
MET A 519
THR A 579
ILE A 582
MET A 583
PHE A 586
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
 0.72A 1xlxB-4wziA:
52.3		 1xlxB-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		9 TYR A 405
HIS A 406
HIS A 450
THR A 579
ILE A 582
MET A 583
PHE A 586
MET A 603
GLN A 615
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
 0.81A 1xlxB-4wziA:
52.3		 1xlxB-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 222
HIS A 223
HIS A 267
MET A 336
THR A 385
PHE A 392
GLN A 421
PHE A 424
 None
4QJ  A 603 ( 4.9A)
None
4QJ  A 603 ( 3.9A)
None
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.63A 1xlxB-5b25A:
44.0		 1xlxB-5b25A:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 7 TYR A 668
HIS A 669
HIS A 713
MET A 785
PHE A 845
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
None
LLN  A1003 (-4.0A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.40A 1xlxB-5h2rA:
39.5		 1xlxB-5h2rA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 7 TYR A 668
HIS A 669
MET A 785
PHE A 845
MET A 862
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
LLN  A1003 (-4.6A)
LLN  A1003 (-3.5A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.73A 1xlxB-5h2rA:
39.5		 1xlxB-5h2rA:
32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyw PROTEASOME SUBUNIT

(Yersinia
bercovieri) 		no annotation 5 TYR A 198
MET A  80
THR A 205
MET A 196
PHE A  14
 None
 1.28A 1xlxB-5nywA:
undetectable		 1xlxB-5nywA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 8 HIS A 406
HIS A 450
MET A 519
MET A 583
PHE A 586
MET A 603
SER A 614
PHE A 618
 None
None
9VE  A 801 (-3.8A)
9VE  A 801 ( 4.0A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
 0.94A 1xlxB-5ohjA:
52.6		 1xlxB-5ohjA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 5 HIS A 446
MET A 519
THR A 579
GLN A 615
PHE A 618
 ZN  A 699 (-3.2A)
9VE  A 801 (-3.8A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
 1.44A 1xlxB-5ohjA:
52.6		 1xlxB-5ohjA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 11 TYR A 405
HIS A 406
HIS A 450
MET A 519
THR A 579
ILE A 582
MET A 583
PHE A 586
MET A 603
GLN A 615
PHE A 618
 None
None
None
9VE  A 801 (-3.8A)
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 ( 4.0A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
 0.62A 1xlxB-5ohjA:
52.6		 1xlxB-5ohjA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta) 		no annotation 5 HIS A  83
HIS A 126
MET A 195
PHE A 258
PHE A 291
 None
 0.49A 1xlxB-5vydA:
40.4		 1xlxB-5vydA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 5 HIS A 200
MET A 273
THR A 333
GLN A 369
PHE A 372
 ZN  A 602 (-3.3A)
AKJ  A 601 ( 3.9A)
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
 1.50A 1xlxB-5wh6A:
52.3		 1xlxB-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 12 TYR A 159
HIS A 160
HIS A 204
MET A 273
THR A 333
ILE A 336
MET A 337
PHE A 340
MET A 357
SER A 368
GLN A 369
PHE A 372
 AKJ  A 601 ( 4.7A)
None
None
AKJ  A 601 ( 3.9A)
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 ( 3.7A)
AKJ  A 601 (-4.5A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-2.5A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
 0.57A 1xlxB-5wh6A:
52.3		 1xlxB-5wh6A:
undetectable